CN1206911C - Compound biocide composite - Google Patents
Compound biocide composite Download PDFInfo
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- CN1206911C CN1206911C CN 00123932 CN00123932A CN1206911C CN 1206911 C CN1206911 C CN 1206911C CN 00123932 CN00123932 CN 00123932 CN 00123932 A CN00123932 A CN 00123932A CN 1206911 C CN1206911 C CN 1206911C
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- described compound
- compound biocide
- biocide composite
- composite
- antiperspirant
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Abstract
The present invention relates to a composite bactericidal composition which is prepared from 10 to 95% of water, 5 to 90 % low molecular alcohol, 0.01 to 10 % of bactericidal agent, 0.001 to 40 % of skin penetration enhancer, 0.1 to 10% of antiperspirant, 0.1 to 10% of cutin softening agent and 0 to 1% of moisture retaining lubricant which form a stable composition under the existence of a proper quantity of solubilizing agent, emulsifying agent, refreshing agent and essence. The composite bactericidal composition is mainly used for preventing and eliminating skin diseases such as bromhidrosis, psoriasis, tinea pedis, smelly feet and body odor caused by microorganisms. At the same time, the composite bactericidal composition can be used for the sterilization, the cleanness, etc. of article surfaces, air, etc.
Description
The invention relates to a kind of compound biocide composite, this composition is by water, low mass molecule alcohol, and antibiotic bactericide, skin penetration enhancer, antiperspirant, cutin healing softening agent, the lubricants of preserving moisture etc. are formed a stable complex composition.This composition can be sub-packed in the suitable vessel, especially be loaded in the quantitative spray bottle or aerosol bottle easy to use, the sterilizing that is used for the human body skin surface, be particularly useful for preventing and eliminating the dermatopathy that causes owing to bacterium, fungi and virus etc.,, skin smelly as skin tinea, the tinea manuum, the ringworm of the foot, underarm odor, pin is disturbed and is itched etc., also has certain effect for skin acne, dermatitis.
By fungi, bacterial skin tinea, the ringworm of the foot, underarm odor is human common skin disease, for the control of this class disease multiple medicine and method is arranged, and its mechanism mainly is to kill the germ that removes the skin surface.The also main antibacterial and anti-inflammation functions of means of prevention for the skin seat sore that causes owing to the endocrine metabolism imbalance, dermatitis etc. by means of some drugs.
The invention provides following a kind of compound biocide composite, it consists of: the water of (1) 10～95% (v/v); The low mass molecule alcohol of (2) 5～90% (v/v); The antibiotic bactericide of (3) 0.01～10% (w/v); The skin penetration enhancer of (4) 0.01～10% (w/v); The antiperspirant of (5) 0.1～10% (w/v); The keratolytic allantoin of (6) 0.1～10% (w/v); The lubricant of preserving moisture of (7) 0～1% (w/v).
In the present invention, component with antibiotic and sterilizing effect adopts confirmed antibiotic bactericide, these antibiotic bactericides have halogeno-benzene ethers such as Triclosan (Triclosan), hibitane class such as chlorhexidine acetate, chlorhexidine gluconate, salicylic acid such as salicylic acid, acetylsalicylic acid, sodium salicylate, gaultherolin, salicylanilide etc., quaternary ammonium salt such as benzalkonium bromide, Domiphen bromide, myristylpicolinum bromide etc.These antibiotic bactericides all have bactericidal effect preferably.These compositions can use separately, but also two or more mixes use.The working concentration of antibiotic bactericide is different and different according to used kind, and consumption is preferably in 0.1～5% at 0.01～10% (w/v) usually.
According to the character and the sterilization characteristics of different bactericide, two or more bactericide can be mixed and use, the effect of, sterilization antibiotic, anti-inflammatory to strengthen.
Product of the present invention is done carrier with water and low mass molecule alcohol, and wherein low mass molecule alcohol can be low molecule monohydric alcohol such as ethanol, isopropyl alcohol, butanols, dihydroxylic alcohols such as propane diols, 1,3-butanediol, 1,4-butanediol, trihydroxylic alcohol such as glycerine.Other water that the low mass molecule alcohol class that contains is mainly used in the assist in dissolving composition are difficult for dissolved constituent, effect such as have assisting sterilisation, flavoring simultaneously concurrently, preserve moisture.The most commonly used with ethanol, isopropyl alcohol, propane diols, glycerine.Low mass molecule alcohol both can be used as solvent, itself had certain antibacterial action (as ethanol, isopropyl alcohol, propane diols) again, had good compatibility with antibiotic bactericide.
In product of the present invention, the water proportion is 10～95%, is preferably 20～60%, and the low mass molecule alcohol proportion is 5～90%, is preferably 20～80%.
The feature of product of the present invention also is to contain skin penetration enhancer in the prescription, and the effect of skin penetration enhancer is to promote the antibiotic and sterilizing medicine can infiltrate below the skin superficial by changing the permeability of skin surface, helps the performance of deep layer bactericidal action.Skin penetration enhancer is widely used in the dermatologic, and a lot of patent formulations all relate to, as USP5196416.The kind of skin penetration enhancer is a lot, polar substance, apolar substance and surfactant etc., the tall and erect ketone (azone) of apolar substance commonly used such as dodecyl nitrogen, the tall and erect ketone of Mang ox base nitrogen, menthol, silicone, cineole etc., polar substances such as dimethyl sulfoxide (DMSO), urea etc., surfactant-based as Tween-80 etc., wherein soil temperature-80 has emulsification, solubilization concurrently.In the product of the present invention, used skin penetration enhancer can be one or more mixing of above-mentioned kind, and wherein tall and erect ketone of dodecyl nitrogen and the tall and erect ketone of Mang ox base nitrogen are more commonly used, and its consumption is relatively also less; Dimethyl sulfoxide (DMSO) is owing to only just have short preferably transdermal effect when usage ratio is big, so generally be more prone to use as solvent; Menthol and cineole are except that short Transdermal absorption effect, because its distinctive refrigerant, flavored action, thereby use also more extensive.The tall and erect ketone of dodecyl nitrogen, the common consumption of the tall and erect ketone of Mang ox base nitrogen are preferably in 0.1～2% at 0.01～10% (w/v); Dimethyl sulfoxide (DMSO) then consumption must reach 2～50% (w/v), is generally 5～40%; Menthol and cineole according to circumstances consumption at 0.001～1% (w/v), usually 0.01～0.2%.
Antiperspirant (antiperspirant) is the metalloid salt with astriction, be often referred to the organic or inorganic salt and the aluminium-zirconium complex salt of aluminium, zirconium, lead etc., as aluminum halide, hydroxyhalides, oxyhalogenation zirconium, hydroxyl zirconium halide, lead monoxide, the inferior lead of sulfocarbolic acid, alum etc., these materials can use separately, also can mix use, U.S. Pat 4743,444, US5932199 etc. have all narrated the usage and the consumption of antiperspirant.Make antiperspirant with water-soluble chlorination aluminium, silver iodide, polymeric aluminum chloride, zirconyl hydroxychloride, alum etc. in the present invention, its amount ranges is preferably 0.1～10% at 0.01～20% (w/v).
In product of the present invention, also added keratolytic, keratolytic is an allantoin, allantoin is used for skin surface, makes skin keratin softening, promotes organization healing, can strengthen the bactericidal effect of antibacterial agent, have certain itching-relieving action simultaneously, consumption is 0.01～10% (w/v), is preferably 0.1～2%.
In the product of the present invention, also added the lubricated composition of preserving moisture, the lubricant of preserving moisture is the glutinous polysaccharose substance of macromolecule, mainly refer to hyaluronic acid or its esters such as sodium salt, sylvite, calcium salt, the hyaluronic lubrication of preserving moisture is can be in conjunction with large quantity of moisture, thereby makes skin surface keep moistening for a long time, in the present invention, the adding of lubricated composition of preserving moisture has prolonged the action time of other composition, and alleviates the discomfort that other compositions may cause site of action to a certain extent.
Hyaluronic acid or its esters can be to extract from animal viscera such as cockscomb by biochemical extracting method, also can separate making by microbial fermentation, though the source is different, its action effect is the same.
In the present invention, the consumption of hyaluronic acid or its esters is 0～1%, and optimum dose is 0.001～0.05%.
In the formula for a product of the present invention, existing water soluble ingredient has water insoluble ingredients again, for making product stability good, gram according to circumstances adds an amount of stabilizing agent in formula for a product, is generally emulsifier, solubilizer, this class stabilizing agent can use emulsifier commonly used, solubilizer.
Also add an amount of freshener, essence in the product of the present invention, so that product has salubrious, pleasant smell.
Product of the present invention is transparent or semitransparent liquid, can be sub-packed in the various commercially available containers, and best use container is quantitative spray bottle or aerosol bottle.
Product of the present invention is a compound biocide composite, it is characterized in that except that containing common antibiotic bactericide, also containing antiperspirant, skin penetration enhancer, keratolytic, the lubricant of preserving moisture being in the mixing mutually of carrier with water and low mass molecule alcohol.Above-mentioned component is made stable compositions through certain production technology in the presence of suitable solubilizer, emulsifier, freshener, essence etc.
The solubilizer that adds in the product of the present invention, emulsifier, freshener, essence are wherein one or more, and its total content is 0～10%.
Product of the present invention can be used for preventing and treating and eliminating because the dermatopathy that pathogenic microbes causes, disturb to itch etc. for psoriasis, the ringworm of the foot, jock itch, skin and have good effect, effectively the abnormal smell of body that brings owing to microbial decomposition such as foot foulness eliminating, underarm odor, body odor.Product of the present invention have effect rapidly, non-greasy, non-pigment pollute,, advantage such as smell salubrious good, non-stimulated with skin-friendliness.
The present invention relates to a kind of like this product, a kind of compound biocide composite wherein contains water, low mass molecule alcohol, antibiotic bactericide, skin penetration enhancer, antiperspirant, keratolytic, the lubricant etc. of preserving moisture.Said composition can be packaged in the commodity container of being convenient to commercially available and use, as quantitative spray bottle, aerosol bottle, is used for cleaning, the sterilization of personal hygiene nursing and article surface, air etc.
Embodiment
Embodiment 1:
Triclosan 4.0g
The tall and erect ketone 5.0g of dodecyl nitrogen
Allantoin 5.0g
Alchlor 6.0g
95% ethanol 400ml
LRI
* 5.0g
Propane diols 50g
The essence trace
Deionized water adds to 1000ml
Method for making: mentioned component is taken by weighing according to quantity, water soluble ingredient such as allantoin, alchlor etc. are dissolved in the suitable quantity of water, add LRI and mix, be component A; Water insoluble active ingredient such as Triclosan, the tall and erect ketone of dodecyl nitrogen, essence etc. are dissolved in the capacity ethanol, mix, be B component.Component A is slowly added in the B component, stir, quantitative filling is to quantitatively getting final product in the spray bottle.
*: LRI is the trade name of a kind of solubilizer of French Li Weike company (Les Colorants Wackherr) production, and its composition is the compound of Crodaret and polypropylene glycol.
Embodiment 2:
Chlorhexidine gluconate 3.0g
Acetylsalicylic acid 1.0g
The tall and erect ketone 6.0g of Mang ox base nitrogen
Menthol 200mg
Soil temperature-80 8.0g
Allantoin 10.0g
Alum 10.0g
95% ethanol 200ml
Isopropyl alcohol 100ml
Sodium Hyaluronate 0.2g
The essence trace
Deionized water adds to 1000ml
Method for making: as embodiment 1 method for making, mentioned component is mixed, can is to quantitative spray bottle or add propellant and be loaded in the aerosol bottle.
Embodiment 3:
Triclosan (Irgasan DP300)
*3g
95% ethanol 600ml
Propane diols 150ml
The tall and erect ketone 10g of Mang ox base nitrogen
Cineole 0.5g
Allantoin 10g
Alum 6g
The essence trace
Deionized water adds to 1000ml
Method for making: as embodiment 1 method for making, mentioned component is mixed, can is to quantitative spray bottle or aerosol bottle.
*: triclosan, Irgasan DP300 are the trade (brand) name of the Triclosan of Switzerland Ciba company (Ciba-Geigy AG) production.
Embodiment 4:
Benzalkonium bromide 1g
Salicylanilide 20g
Isopropyl alcohol 500ml
Glycerine 20ml
The tall and erect ketone 6g of dodecyl nitrogen
Menthol 0.3g
Zirconyl hydroxychloride 5g
Allantoin 6g
Soil temperature-80 10g
The essence trace
Deionized water adds to 1000ml
Method for making: with embodiment 3 method for makings.
Claims (10)
1. compound biocide composite, said composition is composed as follows:
The water of (1) 10～95% (v/v);
The low mass molecule alcohol that is selected from ethanol, isopropyl alcohol, propane diols and glycerine of (2) 5～90% (v/v);
The antibiotic bactericide of (3) 0.01～10% (w/v);
The skin penetration enhancer that is selected from azone, menthol and cineole of (4) 0.001～10% (w/v);
The antiperspirant of (5) 0.1～10% (w/v);
The allantoin of (6) 0.1～10% (w/v);
The hyaluronate of (7) 0～1% (w/v)
Antibiotic bactericide is selected from Triclosan, hibitane, acetylsalicylic acid, bromogeramine and salicylanilide.
2. according to the described compound biocide composite of claim 1, wherein the concentration of low mass molecule alcohol is 20～80%.
3. according to the described compound biocide composite of claim 1, wherein hibitane is chlorhexidine acetate or chlorhexidine gluconate.
4. according to the described compound biocide composite of claim 1, wherein the antibiotic bactericide total amount is 0.1～5%.
5. according to the described compound biocide composite of claim 1, wherein the concentration of skin penetration enhancer is 0.01～10%.
6. according to the described compound biocide composite of claim 1, wherein antiperspirant is selected from water-soluble chlorination aluminium, silver iodide, polymeric aluminum chloride, zirconyl hydroxychloride and alum.
7. according to the described compound biocide composite of claim 1, wherein allantoin concentration is 0.1～2%.
8. according to the described compound biocide composite of claim 1, wherein hyaluronate is hyaluronic sodium salt, sylvite or calcium salt.
9. according to the described compound biocide composite of claim 1, also contain the component that is selected from following material: solubilizer, emulsifier, freshener and essence.
10. the described compound biocide composite of claim 1, the application aspect the cleaning-sterilizing of the sterilizing on human body skin surface or article surface and air.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00123932 CN1206911C (en) | 2000-10-12 | 2000-10-12 | Compound biocide composite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00123932 CN1206911C (en) | 2000-10-12 | 2000-10-12 | Compound biocide composite |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1348686A CN1348686A (en) | 2002-05-15 |
| CN1206911C true CN1206911C (en) | 2005-06-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00123932 Expired - Fee Related CN1206911C (en) | 2000-10-12 | 2000-10-12 | Compound biocide composite |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1206911C (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060051384A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
| CN100522243C (en) * | 2006-03-13 | 2009-08-05 | 新疆维吾尔自治区畜牧科学院兽医研究所 | Animal skin penetrant |
| US20110065798A1 (en) * | 2009-09-17 | 2011-03-17 | Becton, Dickinson And Company | Anti-infective lubricant for medical devices and methods for preparing the same |
| CN102475660A (en) * | 2010-11-29 | 2012-05-30 | 吴克 | Axilla fragrant dew |
| CN102119840A (en) * | 2011-03-10 | 2011-07-13 | 胡万宁 | Hospital infection preventing disposable hand cleaning disinfecting towel for medical personnel and use thereof |
| CN102670437B (en) * | 2012-04-23 | 2013-07-10 | 浙江省农业科学院 | Cool and refreshing mulberry leaf pox eliminating liquid and preparation process thereof |
| CN103432584A (en) * | 2013-08-14 | 2013-12-11 | 金红叶纸业集团有限公司 | Cooling and itching relieving composition and paper towel employing same |
| CN104739664A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Chlorhexidine gluconate bath disinfection liquid and preparation method thereof |
| CN106146885A (en) * | 2015-04-21 | 2016-11-23 | 杭州勤诚塑料包装材料有限公司 | A kind of antibacterial and mouldproof deodorizing composite membrane and preparation method thereof |
| CN105687170A (en) * | 2016-03-03 | 2016-06-22 | 汪守亚 | Long-acting deodorant solution and preparation method thereof |
| GB2552001B (en) * | 2016-07-06 | 2019-06-05 | Reckitt Benckiser Brands Ltd | New air freshening formulation |
| CN107312651A (en) * | 2017-06-26 | 2017-11-03 | 王磊 | A kind of medical adhesive residue remover |
| WO2019056212A1 (en) * | 2017-09-20 | 2019-03-28 | 太仓大唐化纤厂 | Detergent for enhancing antibacterial property of chemical fiber |
| CN109481349A (en) * | 2018-11-30 | 2019-03-19 | 宋月成 | One kind, which is dispelled, savours facial treatment milk and preparation method thereof |
| CN109674376A (en) * | 2018-12-25 | 2019-04-26 | 阜阳市长海环保设备科技有限公司 | A kind of mobile phone one of cephalocathartic disinfection and sterilization cleans wet tissue |
| CN111821496A (en) * | 2019-04-20 | 2020-10-27 | 广东阜和实业有限公司 | Deodorizing condensation bead and preparation method thereof |
| CN111821838A (en) * | 2019-04-20 | 2020-10-27 | 广东阜和实业有限公司 | Aerosol type air deodorant and preparation method thereof |
| CN110693981A (en) * | 2019-11-29 | 2020-01-17 | 长沙九超生物科技有限公司 | Liquid for treating bromhidrosis and preparation method thereof |
-
2000
- 2000-10-12 CN CN 00123932 patent/CN1206911C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1348686A (en) | 2002-05-15 |
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Granted publication date: 20050622 Termination date: 20101012 |