CN1204915C - Detoxification capsule and its prodn. methods - Google Patents
Detoxification capsule and its prodn. methods Download PDFInfo
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- CN1204915C CN1204915C CN 03110806 CN03110806A CN1204915C CN 1204915 C CN1204915 C CN 1204915C CN 03110806 CN03110806 CN 03110806 CN 03110806 A CN03110806 A CN 03110806A CN 1204915 C CN1204915 C CN 1204915C
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Abstract
The present invention relates to a detoxification capsule which is prepared from 0.2 to 40g of honeysuckle flower, 0.2 to 40g of forsythia, 0.2 to 40g of scutellaria root, 0.2 to 40g of isatis root, 0.3 to 60g of gypsum and 0.2 to 20g of Chinese ephedra. The present invention has the effects of dispelling wind and heat, clearing away heat and toxic materials, relieving sore throat and relieving cough, and is used for treating diseases, such as fever, headache, pharyngitis, cough, nasal obstruction, rhinitis, etc., which are caused by wind-heat type common cold. After put on the market, the present invention has the advantages of good curative effect, convenient use, no toxic or side effect, etc. The present invention is suitable for many patients, and has a broad market prospect.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine, specifically relate to a kind of Chinese medicine wafer for the treatment of cold disease, and production technology,
(2) background technology
Viral influenza is a kind of multiple commonly encountered diseases, catches a cold at least more than 1,000,000,000 person-times every year in the whole nation.The treatment primary disease is mainly based on infection at present.
Viral influenza is a kind of acute upper respiratory tract infectious disease that is caused by virus or bacterial infection, has characteristics such as onset is anxious, sickness rate is high, infection is fast, harm is big.
Because virus has strict parasitics, duplicates in host cell, utilizes the cellular enzymes system, and is close with cell relation, viral nucleic acid is integrated in cell sometimes and is difficult for eliminating.Therefore, the development of antiviral class medicine is very slow.Anti-cold virus class medicine that existing market is commonly used such as amantadine, the two melons of morpholine and ribavirin (virazole) are chemicals.Amantadine inside and outside antiviral activity only limits to influenza A virus, though external also have activity to parainfluenza and rubella virus, valid density is than suppressing the big 50-100 of influenza A virus doubly.Untoward reaction has delirium, anxiety, insomnia, thought to concentrate difficulty, and idol has epilepsy during high plasma concentration, congestive heart failure is also arranged, diseases such as netted malicious speckle and arrhythmia.Ribavirin is strong to the RNA viruses effect, and the end of than, untoward reaction is mainly the reversibility anemia to DNA viruses sensitivity, takes for a long time hematochrome, RBC number, packed cell volume are descended.
Chinese medicine has bigger advantage at anti-virus aspect, and this is proved by clinical and test.Especially the integral body of the traditional Chinese medical science see, dialectical execute control, integrally-regulated.This is that the herbal mixture clinical efficacy is better than folk prescription Chinese medicine, is better than chemical drugs, has the theoretical basis of broad-spectrum antivirus action.
One of antiviral approach of Chinese medicine is directly to suppress virus, by the absorption in the blocking virus reproductive process, penetrate, duplicate, a certain link in the maturation plays antiviral purpose.
(3) summary of the invention
The technical problem to be solved in the present invention provides a kind of Chinese medicinal capsule for the treatment of viral influenza.This court has been carried out developmental research for many years, finished the physicochemical property relevant, quality standard, stability test, pharmacodynamics test, acute toxicity test and clinical trial with quality.The technical problem that needs emphasis to solve is an antivirus test, is born and is finished by the Affiliated Hospital Viral Laboratory.
This research is leading indicator with this Chinese medicinal capsule antivirus test, and analgesic, antiinflammatory, antibacterial, cough-relieving and pain relieving are auxiliary characteristics.Main prevention and the therapeutical effect of observing Chinese medicinal capsule of the present invention to FM/1/47 influenza virus induced mice viral pneumonia in antivirus test, the measurement result of the blood clotting titre by lung index, histopathology, virus, RNA, inducement interferon level is come the antivirus action of analysis-by-synthesis Chinese medicinal capsule.Wherein the mensuration of viral RNA and interferon is that the applied molecular biology technology is finished, and science is reliable as a result.
Medicament selection that adopts and compatibility program and manufacturing technique method are:
One, medicament selection and compatibility program:
A kind of Chinese medicinal capsule for the treatment of viral influenza is to be mixed with by Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Isatidis, Gypsum Fibrosum, Herba Ephedrae, and its compatibility is:
Flos Lonicerae 1-3g, Fructus Forsythiae 1-3g, Radix Scutellariae 1-3g, Radix Isatidis 1-3g, Gypsum Fibrosum 1.5-5g, Herba Ephedrae 0.5-1.5g.
Also add Semen Armeniacae Amarum 0.6-1.5g, Radix Glycyrrhizae 0.5-2g, Folium Isatidis 1g after the parch in the prescription of the present invention.
Two, a kind of method of manufacturing technology for the treatment of the Chinese medicinal capsule of viral influenza is:
Need extracting honeysuckle 1000-3000g, Radix Scutellariae 1000-3000g by compatibility, with Flos Lonicerae, Radix Scutellariae with the alcohol reflux of 50-99% two to three times, for the first time adding ethanol 4-10 doubly measures, extracted 1-4 hour, for the second time add ethanol 4-10 and doubly measure, extracted 1-3 hour, filter, merge filtrate twice, reclaim ethanol and be evaporated to the clear paste that relative density is 1.15-1.20 (55-60 a ℃); Fructus Forsythiae 1000-3000g adds water 5-12 and doubly measures, and vapor distillation 2-5 hour, collect volatile oil with volatile oil extractor, volatile oil is prepared into beta-cyclo dextrin included compound with beta-schardinger dextrin-, and is ground into fine powder; Aqueous solution after the distillation filters, and filtrate device is in addition collected standby; Gypsum Fibrosum 1500-5000g adds water 5-10 and doubly measures decoction 0.5-1 hour, add Radix Isatidis 1000-3000g, Herba Ephedrae 500-1500g, add for the first time water 5-12 and doubly measure decoction 1-4 hour, filter, filtering residue and Radix Scutellariae, Flos Lonicerae, the Fructus Forsythiae slag merges, add water 5-12 and doubly measure decoction 1-4 hour, filter, aqueous solution after merging filtrate and the Fructus Forsythiae distillation, being evaporated to relative density is the clear paste of 1.20-1.25 (55-60 ℃), adding ethanol makes and contains the alcohol amount and reach 60-80%, stir, leave standstill filtration in 8-24 hour, twice of 60-80% washing with alcohol of residue, each 600-1000ml, filter, merging filtrate, reclaim ethanol and be evaporated to the clear paste that relative density is 1.15-1.20 (55-60 a ℃) with single effect evaporator, with above-mentioned Flos Lonicerae, the Radix Scutellariae clear paste mixes, with spray dryer spray drying (inlet temperature 140-160 ℃), get dry thing and beta-cyclo dextrin included compound mix homogeneously, with concentration is 40-60% ethanol spray granulation, in thermostatic drying chamber, at temperature drying below 50 ℃, incapsulate, be finished product.
Three, it is identical with said method to contain the method for manufacturing technology of Chinese medicinal capsule of treatment viral influenza of Semen Armeniacae Amarum, Radix Glycyrrhizae, Folium Isatidis, Semen Armeniacae Amarum 600-1500g, the Radix Glycyrrhizae 500-2000g, the Folium Isatidis 200-400g that get by compatibility, be in above-mentioned process for making, join in the parget water that decocts 0.5-1 hour with Radix Isatidis.
The side separates:
Flos Lonicerae: sweet trembling with fear into lung, Fructus Forsythiae hardship are slightly cold and also go into lung, and two medicine mutual reinforcements between are usefulness, and existing dispelling wind and heat pathogens, expelling pathogenic factors from the exterior be soothing the liver usefulness outward, and the merit of repelling foulness with aromatics, heat-clearing and toxic substances removing is arranged again.Can be the pathogenesis that hits, so be monarch drug in the side altogether.
Radix Scutellariae: bitter cold is gone into lung, also belongs to the product of clearing away heat-fire detoxifcation.Kind " fire of the clear part of the body cavity above the diaphragm housing the heart and lungs " (" book on Chinese herbal medicine is just "), " controlling wind heat " (Compendium of Material Medica), " main all heat " (" herbal classic ").
Radix Isatidis: bitter cold, be longer than heat-clearing and toxic substances removing, the removing heat from blood sore-throat relieving.Gypsum Fibrosum is gone into lung sweet hot Great Cold, and the power of clearing away heat-fire is stronger.Can remove " headache fever of the body, the big heat of three warmers, skin heat ", " expelling pathogenic factors from muscles by diaphoresis " (" Mingyi Bielu ").Last three flavor clearing away heat-fires, removing pathogenic heat from blood and toxic substance from the body, the power of closing principal drug assistance is known and is ministerial drug in the side.
Herba Ephedrae: hot little bitter temperature, return lung meridian, the energy relieving the exterior syndrome by diaphoresis, the heat of getting rid of evils is outer to be reached, and can hardship fall lung qi, depressed lung-energy dispersing again.It has Gypsum Fibrosum to make mutually, can delay warm property, and " and dispersing not violent " (" herbal classic is dredged card ") stresses to bring into play the flat function of coughing of cough-relieving.The Semen Armeniacae Amarum tepor is also gone into lung meridian, is the product of sending down the abnormal ascending QI relieving cough and asthma, and with Herba Ephedrae mutually 5, " eliminating the pathogens from the lung and promoting the circulation of QI " (" book on Chinese herbal medicine is looked for the truth ") becomes dispersing and lowering lung-QI, the effect of relieving cough and asthma, and the duty of department's adjuvant drug altogether.
Radix Glycyrrhizae: Gan Ping and go into lung meridian, merit is held two ends, and heat-clearing and toxic substances removing, expelling phlegm for arresting cough are one; Coordinating the actions of various ingredients in a prescription, collaborative for be its two.Yu Fangzhong makes assistant and makes it agent.
Comprehensively above-mentioned, all eight product in full side, with Maxingshigan Tonga flavor, the wind heat of loosing is separated pyretic toxicity, to cure the disease originally; Throat, cough-relieving is breathed heavily, and separates the mark of disease.Drug regimen is rational in infrastructure, and no too fat to move mixed and disorderly suspicion is so its merit can become.
Clinical trial:
Use Chinese medicinal capsule treatment viral influenza 30 examples of treatment viral influenza of the present invention, adopt SHUANGHUANGLIAN JIAONANG to compare.The Chinese medicinal capsule group of result's treatment viral influenza of the present invention is cured 13 examples, and cure rate is 43%, produce effects 14 examples, and obvious effective rate is 47%, progressive 3 examples account for 10%.The SHUANGHUANGLIAN JIAONANG group is cured 10 examples, and cure rate is 33%, produce effects 15 examples, and obvious effective rate is 50, progressive 5 examples account for 17%.From clinical efficacy as seen, the Chinese medicinal capsule of treatment viral influenza of the present invention slightly is better than SHUANGHUANGLIAN JIAONANG, obviously is better than the SHUANGHUANGLIAN JIAONANG group at the Chinese medicinal capsule of treatment viral influenza of the present invention aspect the treatment of clinical symptoms such as the heating due to viral influenza, cough.
Acute toxicity test method:
Get 30 of mices, be divided into 3 groups at random by the body weight size, 10 every group, male and female half and half, each organizes mice respectively by the dosage gastric infusion of 87g/kg, 69.6g/kg, 56.6g/kg (being equivalent to the crude drug amount) once, observes 7 days after the administration.General situation and the death toll of record mice.
The result:
The Chinese medicinal capsule of table 1 treatment viral influenza is to the acute toxicity of mouse stomach administration
General situation after group dosage (g/kg) number of animals (only) death toll (only) administration
First group 87.0 10 0 no abnormal
Second group 69.6 10 0 no abnormal
The 3rd group 56.6 10 0 no abnormal
By table 1 result as seen, the Chinese medicinal capsule of treatment viral influenza fails to measure LD for gastric infusion of mice
50
Maximum tolerance determination:
Method:
Get 20 of mices, male and female half and half, all disposable filling stomach is treated the Chinese medicinal capsule 87g/kg (being equivalent to the crude drug amount) of viral influenza, observes 7 days continuously after the administration, and observe once every day, general situation and the death toll of record mice.
The result:
Observed 7 days after the administration, none death of mice, general situation, activity and diet are all normal.The maximum tolerated dose of the Chinese medicinal capsule single administration of treatment viral influenza is to treat the Chinese medicinal capsule of viral influenza by 87g/kg (being equivalent to the crude drug amount), is equivalent to 175 times of people (70kg) daily dose.
Function cures mainly:
Dispelling wind and heat pathogens, heat-clearing and toxic substances removing, smooth throat to stop cough.Be used for diseases such as anemopyretic cold finding fever of the body, distending pain in the head, red swelling and pain of throat, cough, nasal obstruction stream turbid nasal discharge.
Adapt to the disease cause of disease, pathogenesis and method of treatment:
Flu belong to wind heat person, how to go into interior the house due to the lung through mouth and nose by the heresy of affection due to external wind and heat.Or be affected by the cold in advance, strongly fragrant immediately and heat-transformation, hot smoking lung system, inside fire attack forms in lung.Because of lung and fur are harmonious, wind heat is attacked in the flesh table, so see fever of the body, distending pain in the head; The heresy of wind heat is invaded lung system, causes disturbance of lung-QI, and sees nasal obstruction stream turbid nasal discharge; The smoked throat that burns of wind heat is seen red swelling and pain of throat then; The wind heat inside fire attack is stopped up and is held back in lung, impairment of dispersing and descending function of the lung, the disease that cough is seen in the whence.For anemopyretic cold, it is controlled when the instruction that abide by " wind is excessive in interior, controls with hot cool, help sweet with hardship " (" element ask the most pure virginity will by "), specifically adopts dispelling wind and heat pathogens, heat-clearing and toxic substances removing, the method for smooth throat to stop cough.
[usage and consumption] is oral, one time 4,3 times on the one.
[specification] every 0.3-0.5g.
The Chinese medicinal capsule of treatment viral influenza of the present invention, the treatment viral influenza, good effect, easy to use, nontoxic pair of effect.
(4) specific embodiment
Embodiment one
A kind of Chinese medicinal capsule for the treatment of viral influenza is to be mixed with by Flos Lonicerae 1g, Fructus Forsythiae 1g, Radix Scutellariae 1g, Radix Isatidis 1g, Gypsum Fibrosum 1.5g, Herba Ephedrae 0.5g.
Embodiment two
A kind of Chinese medicinal capsule for the treatment of viral influenza is to be mixed with by the Semen Armeniacae Amarum 0.6g after Flos Lonicerae 1g, Fructus Forsythiae 1g, Radix Scutellariae 1g, Radix Isatidis 1g, Gypsum Fibrosum 1.5g, Herba Ephedrae 0.5g, the parch, Radix Glycyrrhizae 0.5g, Folium Isatidis 1g.
Embodiment three
A kind of Chinese medicinal capsule for the treatment of viral influenza is to be mixed with by the Semen Armeniacae Amarum 1.5g after Flos Lonicerae 3g, Fructus Forsythiae 3g, Radix Scutellariae 3g, Radix Isatidis 3g, Gypsum Fibrosum 5g, Herba Ephedrae 1.5g, the parch, Radix Glycyrrhizae 2g.
Embodiment four
A kind of Chinese medicinal capsule for the treatment of viral influenza is to be mixed with by the Semen Armeniacae Amarum 6g after Flos Lonicerae 10g, Fructus Forsythiae 10g, Radix Scutellariae 10g, Radix Isatidis 10g, Gypsum Fibrosum 15g, Herba Ephedrae 5g, the parch, Radix Glycyrrhizae 5g.
Embodiment five
A kind of manufacturing technique method for the treatment of the Chinese medicinal capsule of viral influenza:
Get 1000g Flos Lonicerae, Radix Scutellariae with 60% alcohol reflux twice, add 7 times of amounts of ethanol for the first time, extracted 1.5 hours, for the second time add 5 times of amounts of ethanol, extracted 1 hour, filter, merge filtrate twice, reclaim ethanol and be evaporated to the clear paste that relative density is 1.15-1.20 (55-60 a ℃); Get the 1000g Fructus Forsythiae and add 10 times of amounts of water, vapor distillation 3 hours is collected volatile oil, volatile oil is prepared into beta-cyclo dextrin included compound with beta-schardinger dextrin-, and is ground into fine powder; Aqueous solution after the distillation filters, and filtrate device is in addition collected standby; Get the 1500g Gypsum Fibrosum and add water 8 amount decoctions 0.5 hour, add Radix Isatidis 1000g, Herba Ephedrae 500g, the Semen Armeniacae Amarum 600g that parch is handled, behind the Radix Glycyrrhizae 500g, add 8 times of amounts of water for the first time and decocted 2 hours, filter, the gained filtrate for later use, filtering residue and Radix Scutellariae slag, the Flos Lonicerae slag, the Fructus Forsythiae slag merges, and adds 7 times of amounts of water, decocted 1 hour, filter, merge the aqueous solution after twice filtrate is distilled with Fructus Forsythiae, being evaporated to relative density is the clear paste of 1.20-1.25 (55-60 ℃), adding ethanol makes and contains the alcohol amount and reach 70%, stir, left standstill 24 hours, filter, residue is with twice of 70% washing with alcohol, each 800ml filters merging filtrate, reclaim ethanol and be evaporated to the clear paste that relative density is 1.15-1.20 (55-60 a ℃), with above-mentioned Flos Lonicerae, the Radix Scutellariae clear paste mixes, and uses the spray dryer drying, 160 ℃ of inlet temperatures, get dry thing and beta-cyclo dextrin included compound mix homogeneously, with 50% ethanol spray granulation, put into thermostatic drying chamber, dry down at 50 ℃, divide the capsule of packing into, promptly.
[character] this product is a capsule, and content is the yellowish-brown granule, bitter in the mouth.
Claims (8)
1, a kind of Chinese medicinal capsule for the treatment of viral influenza, it is characterized in that being mixed with by Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Isatidis, Gypsum Fibrosum, Herba Ephedrae, its compatibility is Flos Lonicerae 1-3g, Fructus Forsythiae 1-3g, Radix Scutellariae 1-3g, Radix Isatidis 1-3g, Gypsum Fibrosum 1.5-5g, Herba Ephedrae 0.5-1.5g.
2, a kind of Chinese medicinal capsule for the treatment of viral influenza according to claim 1 is characterized in that also adding Semen Armeniacae Amarum 0.6-1.5g, Radix Glycyrrhizae 0.5-2g, the Folium Isatidis 1g of parch in described compatibility.
3, a kind of Chinese medicinal capsule for the treatment of viral influenza according to claim 1 is characterized in that being mixed with by Flos Lonicerae 1g, Fructus Forsythiae 1g, Radix Scutellariae 1g, Radix Isatidis 1g, Gypsum Fibrosum 1.5g, Herba Ephedrae 0.5g.
4, a kind of Chinese medicinal capsule for the treatment of viral influenza according to claim 2 is characterized in that being mixed with by the Semen Armeniacae Amarum 0.6g after Flos Lonicerae 1g, Fructus Forsythiae 1g, Radix Scutellariae 1g, Radix Isatidis 1g, Gypsum Fibrosum 1.5g, Herba Ephedrae 0.5g, the parch, Radix Glycyrrhizae 0.5g, Folium Isatidis 1g.
5 a kind of Chinese medicinal capsules for the treatment of viral influenza according to claim 2 is characterized in that being mixed with by the Semen Armeniacae Amarum 1.5g after Flos Lonicerae 3g, Fructus Forsythiae 3g, Radix Scutellariae 3g, Radix Isatidis 3g, Gypsum Fibrosum 5g, Herba Ephedrae 1.5g, the parch, Radix Glycyrrhizae 2g.
6, a kind of Chinese medicinal capsule for the treatment of viral influenza according to claim 2 is characterized in that being mixed with by the Semen Armeniacae Amarum 6g after Flos Lonicerae 10g, Fructus Forsythiae 10g, Radix Scutellariae 10g, Radix Isatidis 10g, Gypsum Fibrosum 15g, Herba Ephedrae 5g, the parch, Radix Glycyrrhizae 5g.
7, a kind of production method for the treatment of the Chinese medicinal capsule of viral influenza according to claim 1, it is characterized in that needing extracting honeysuckle, Radix Scutellariae by compatibility, with Flos Lonicerae, Radix Scutellariae with the alcohol reflux of 50-99% two to three times, for the first time add ethanol 4-10 and doubly measure, extracted 1-4 hour, add ethanol 4-10 for the second time and doubly measure, extracted 1-3 hour, filter, merge filtrate twice, recovery ethanol is evaporated to relative density and is the clear paste of 1.15-1.20 under 55-60 ℃ of temperature; Fructus Forsythiae adds water 5-12 doubly to be measured, and vapor distillation 2-5 hour, collect volatile oil with volatile oil extractor, volatile oil is prepared into beta-cyclo dextrin included compound with beta-schardinger dextrin-, and is ground into fine powder; Aqueous solution after the distillation filters, and filtrate device is in addition collected standby; Gypsum Fibrosum adds water 5-10 and doubly measures decoction 0.5-1 hour, add Radix Isatidis, Herba Ephedrae, add for the first time water 5-12 and doubly measure decoction 1-4 hour, filter, filtering residue and Radix Scutellariae, Flos Lonicerae, the Fructus Forsythiae slag merges, and adds water 5-12 and doubly measures decoction 1-4 hour, filters, aqueous solution after merging filtrate and the Fructus Forsythiae distillation, be evaporated to relative density and under 55-60 ℃ of temperature, be the clear paste of 1.20-1.25, add ethanol and make and contain the alcohol amount and reach 60-80%, stir, leave standstill filtration in 8-24 hour, residue 60-80% washing with alcohol twice, each 600-1000ml filters, merging filtrate, reclaim ethanol and be evaporated to relative density with single effect evaporator and under 55-60 ℃ of temperature, be the clear paste of 1.15-1.20, with above-mentioned Flos Lonicerae, the Radix Scutellariae clear paste mixes, and uses the spray dryer spray drying, inlet temperature 140-160 ℃ gets dry thing and beta-cyclo dextrin included compound mix homogeneously, with concentration is 40-60% ethanol spray granulation, in thermostatic drying chamber, at temperature drying below 50 ℃, incapsulate, promptly.
8, a kind of manufacturing technique method for the treatment of the Chinese medicinal capsule of viral influenza is characterized in that:
Get 1000g Flos Lonicerae, Radix Scutellariae with twice of 60% alcohol reflux, add for the first time 7 times of amounts of ethanol, extracted 1.5 hours, add for the second time 5 times of amounts of ethanol, extracted 1 hour, filtration merges filtrate twice, reclaims ethanol and be evaporated to relative density to be the clear paste of 1.15-1.20 under 55-60 ℃ of temperature; Get the 1000g Fructus Forsythiae and add 10 times of amounts of water, vapor distillation 3 hours is collected volatile oil, volatile oil is prepared into beta-cyclo dextrin included compound with beta-schardinger dextrin-, and is ground into fine powder; Aqueous solution after the distillation filters, and filtrate device is in addition collected standby; Get the 1500g Gypsum Fibrosum and add water 8 amount decoctions 0.5 hour, add Radix Isatidis 1000g, Herba Ephedrae 500g, the Semen Armeniacae Amarum 600g that parch is handled, behind the Radix Glycyrrhizae 500g, add 8 times of amounts of water for the first time and decocted 2 hours, filter, the gained filtrate for later use, filtering residue and Radix Scutellariae slag, the Flos Lonicerae slag, the Fructus Forsythiae slag merges, and adds 7 times of amounts of water, decocted 1 hour, filter, merge the aqueous solution after twice filtrate is distilled with Fructus Forsythiae, be evaporated to relative density and under 55-60 ℃ of temperature, be the clear paste of 1.20-1.25, adding ethanol makes and contains the alcohol amount and reach 70%, stir, left standstill 24 hours, filter, residue is with twice of 70% washing with alcohol, each 800ml filters merging filtrate, reclaim ethanol and be evaporated to relative density and under 55-60 ℃ of temperature, be the clear paste of 1.15-1.20, with above-mentioned Flos Lonicerae, the Radix Scutellariae clear paste mixes, and uses the spray dryer drying, 160 ℃ of inlet temperatures, get dry thing and beta-cyclo dextrin included compound mix homogeneously, with 50% ethanol spray granulation, put into thermostatic drying chamber, 50 ℃ of dryings, divide the capsule of packing into, promptly.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708275B (en) * | 2009-11-27 | 2012-11-28 | 北京市卫生局临床药学研究所 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
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| CN101332254B (en) * | 2007-06-28 | 2010-09-29 | 保定冀中药业有限公司 | Traditional Chinese medicine composition for preventing and treating poultry respiratory disease |
| CN102716223B (en) * | 2012-06-27 | 2014-01-15 | 宁波保税区欣诺生物技术有限公司 | Chinese medicinal composition for treating upper respiratory tract infection and preparation method thereof |
| CN103432234B (en) * | 2013-07-26 | 2014-12-10 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition used for preventing and treating bird flu and newcastle disease of poultry, and preparation method thereof |
| CN104706766A (en) * | 2013-12-11 | 2015-06-17 | 天津嘉创生物科技有限公司 | Oral liquid with heat clearing, toxicity removing, and cough and asthma relieving functions and preparation method thereof |
| CN104306876A (en) * | 2014-09-26 | 2015-01-28 | 赵世明 | Traditional Chinese medicinal composition for treating anemopyretic cold |
| CN109078068A (en) * | 2018-10-26 | 2018-12-25 | 何凤姣 | A kind of cold drug and preparation method thereof |
| CN109528943A (en) * | 2019-01-16 | 2019-03-29 | 谢文纬 | A kind of formula of the highly enriched ball of anti influenza Chinese medicine and preparation |
| CN110772492A (en) * | 2019-10-31 | 2020-02-11 | 冯东东 | Preparation method of cold capsule |
| CN113750188B (en) * | 2020-06-05 | 2022-06-10 | 西安新润药业有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating cold |
| CN113018344A (en) * | 2021-04-01 | 2021-06-25 | 广西南宁霖晟医药科技有限公司 | Traditional Chinese medicine for preventing and treating influenza and upper respiratory tract infection |
| CN113855762B (en) * | 2021-09-18 | 2023-09-19 | 聚协昌(北京)药业有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708275B (en) * | 2009-11-27 | 2012-11-28 | 北京市卫生局临床药学研究所 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
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