CN1193777C - 感冒脐疗中药制剂及其生产方法 - Google Patents
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Abstract
Description
病毒 | 组别 | 药物剂量(mg) | 血凝阴性胚数治疗组 预防组 |
甲1型/京防 | 对照 | 0 | 0 0 |
86-1 | 本发明 | 200 | 6* 8* |
本发明 | 100 | 5* 6* | |
金刚烷胺 | 2.0 | 5* 5* | |
甲3型/桂防 | 对照 | 0 | 0 0 |
96-127 | 本发明 | 200 | 7*< 9*< |
本发明 | 100 | 4 7*< | |
金刚烷胺 | 2.0 | ||
乙型/桂防 | 对照 | 0 | 0 0 |
96-234 | 本发明 | 200 | 6* 6* |
本发明 | 100 | 5* 5* | |
金刚烷胺 | 2.0 | 6* 6* |
样品稀释度 | 金黄色葡萄球菌 | 甲型溶血性链球菌 | 乙型溶血性链球菌 | A族链球菌 |
1∶2 | - | - | - | - |
1∶4 | - | - | - | - |
1∶8 | - | - | - | - |
1∶16 | + | + | - | - |
1∶32 | + | + | + | - |
组别 | 剂量(g/kg) | 肿胀度(mg) |
空白对照 | - | 8.60±2.78 |
阿司匹林 | 0.25 | 3.35±1.72… |
本发明 | 1.0 | 5.60±3.68 |
本发明 | 0.5 | 7.55±4.83 |
组别 | 剂量(g/kg) | 基础痛因(8) | 30′ | 药后60′ | 痛因90′ | 差值(秘)120′ |
空白对照 | - | 9.2±1.8 | 0.1±1.2 | 0.3±1.8 | 0.8±1.3 | 0.7±1.8 |
阿司匹林 | 0.00 | 8.2±1.2 | 5.4±2.9*** | 3.7±1.8*** | 2.1±1.7 | 1.0±1.8 |
本发明 | 1.0 | 8.0±0.7 | 6.7±3.6*** | 0.3±3.2*** | 4.0±1.7*** | 3.2±2.5* |
本发明 | 0.5 | 8.4±1.4 | 4.6±2.0** | 0.3±2.2** | 2.2±2.9 | 1.9±2.2 |
组别 | 剂量g/kg | 正常肛温(C) | 4 | 致热后(h)肛5 | 温差值(℃)6 | 7 |
空白对照 | - | 36.9±0.64 | 0.66±0.22 | 1.71±0.86 | 1.91±0.67 | 2.00±0.48 |
阿司匹林 | 0.00 | 37.2±0.76 | 0.50±0.29 | 0.90±0.57 | 0.97±0.88** | 0.74±0.46*** |
本发明 | 1.0 | 36.5±1.40 | 0.57±0.24 | 1.05±0.07 | 1.40±0.73 | 1.59±0.88 |
本发明 | 1.5 | 36.5±0.54 | 0.56±0.25 | 0.86±0.35* | 1.81±0.76 | 1.60±0.53 |
组别 | 剂量(kg) | 咳嗽潜伏期(日) | 3分钟内咳嗽次数 |
空白对照 | - | 53.22±8.92 | 74.55±25.96 |
磷酸可待因 | 3mg | 83.00±13.05*** | 51.20±22.48* |
本发明 | 1.0g | 82.6±41.9* | 35.66±19.61** |
本发明 | 0.5g | 60.6±19.1 | 53.30±16.52* |
轻度(记2分) | 中度(记4分) | 重度(记6分) | |
发热 | 37-38℃ | 38-39℃ | 39℃- |
头痛 | 轻、偶尔出现 | 较甚,间断出现 | 重,发作频繁,影响休息 |
鼻塞 | 轻,偶尔出现 | 较甚,通气明显减少 | 重,不通气 |
流涕 | 少,偶尔出现 | 较甚,间断出现 | 重,持续出现 |
喷嚏 | 少,偶尔出现 | 较甚,间断出现 | 重,持续出现 |
咳嗽 | 轻,偶尔出现 | 较甚,间断出现 | 重,发作频繁,影响休息 |
咯痰 | 量少,色白而稀 | 量较多,易咯 | 量多,持续出现 |
咽干痛 | 轻,偶尔出现 | 较甚,间断出现 | 重,持续出现 |
咽充血 | 限于咽后壁 | 咽后壁,侧索 | 咽后壁,侧索,悬雍垂 |
例数 | 男 | 女 | |
治疗组 | 200 | 95 | 105 |
对照组 | 120 | 59 | 61 |
例数 | -27岁 | -37岁 | -47岁 | -57岁 | 58岁- | |
治疗组 | 200 | 119 | 34 | 29 | 14 | 4 |
对照组 | 120 | 70 | 23 | 16 | 8 | 3 |
例数 | -1天 | -2天 | |
治疗组 | 200 | 99 | 101 |
对照组 | 120 | 55 | 65 |
例数 | 治疗前积分 | |
治疗组 | 100 | 19.98±8.27 |
对照组 | 120 | 20.09±8.39 |
例数 | 痊愈(%) | 显效(%) | 有效(%) | 无效(%) | 总有效(%) | |
治疗组 | 200 | 52(26.00) | 63(31.50) | 63(34.00) | 17(8.50) | 183(91.50) |
对照组 | 120 | 32(26.67) | 40(33.3) | 37(30.83) | 11(9.17) | 109(90.83) |
例数 | 改善3级 | 改善2级 | 改善1级 | 无改善 | ||
发 热 | 治疗组对照组 | 9047 | 72 | 2814 | 4528 | 103 |
头 痛 | 治疗组对照组 | 15889 | 133 | 6532 | 7250 | 84 |
鼻 塞 | 治疗组对照组 | 177111 | 1913 | 6836 | 7351 | 1712 |
流 涕 | 治疗组对照组 | 16898 | 2613 | 6137 | 6737 | 1711 |
喷 嚏 | 治疗组对照组 | 14699 | 169 | 5341 | 6142 | 171 |
咳 嗽 | 治疗组对照组 | 11371 | 11 | 2929 | 4029 | 4322 |
咯 痰 | 治疗组对照组 | 8847 | 31 | 1815 | 2815 | 3916 |
咽干痛 | 治疗组对照组 | 16097 | 102 | 4931 | 7448 | 2716 |
咽充血 | 治疗组对照组 | 174108 | 42 | 5228 | 7055 | 4823 |
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CN1193777C true CN1193777C (zh) | 2005-03-23 |
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CN109674978A (zh) * | 2019-02-25 | 2019-04-26 | 成都青羊了己中医诊所有限公司 | 用于小儿风热感冒的复方精油组合物及其制成的制剂 |
CN116966224B (zh) * | 2023-04-27 | 2024-03-19 | 广东省时珍本草科学研究院 | 银胡感冒退热外用制剂的制备方法 |
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