CN1190347A - Fish oil and garlic nutritive composition - Google Patents

Fish oil and garlic nutritive composition Download PDF

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Publication number
CN1190347A
CN1190347A CN96195324A CN96195324A CN1190347A CN 1190347 A CN1190347 A CN 1190347A CN 96195324 A CN96195324 A CN 96195324A CN 96195324 A CN96195324 A CN 96195324A CN 1190347 A CN1190347 A CN 1190347A
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Prior art keywords
fish oil
lozenge
capsaicin
rutin
supplementary
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CN96195324A
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H·S·斯拉
D·法恩
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Viva America Marketing Inc
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Viva America Marketing Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to nutritional supplements to the human diet used to increase levels of HDL, and decrease levels of O-LDL, cholesterol, and triglycerides in human blood plasma. More specifically, the present invention teaches a novel nutritional supplements which contain a novel combination of fish oil, garlic, rutin, and capsaicin, as well as methods of preparing the nutritional supplements.

Description

Fish oil and garlic nutritive composition
The introduction of relevant application
The application be submitted on March 12nd, 1996 unsettled provisional application, the partial continuous application that application number is disclosed.
Background of the present invention
1. scope of the present invention
The invention provides the new compositions that is used to prevent people's cardiovascular system central vessel disease, relate to the nutrient composite that comprises fish oil, Bulbus Allii, rutin and capsaicin more precisely, they can reduce the level of triglyceride in the human serum, cholesterol and low density lipoprotein, LDL (LDL) and increase the level of human serum middle-high density lipoprotein (HDL).
2. background of the present invention
In recent years, the scientific research document provides strong evidence for the real contact between micronutrient compositions (for example vitamin, mineral, fish oil and plant extract) and the cardiovascular disease.With regard to the mankind's high-risk cardiovascular disease, it is vital for reducing cardiopathic danger that known realization reduces cholesterol high in the human serum, triglyceride, low density lipoprotein, LDL (LDL) significantly.The effect of also knowing the level increase that makes high density lipoprotein (HDL) also can reduce cardiopathic danger significantly.
The known cardiovascular disease that causes that forms by arterial plaque (arterial plaque) is to cause human diseases and main causes of death.Arterial plaque is that the main deposit that is formed by the low density lipoprotein, LDL (O-LDL) of oxidation causes.The known speckle that forms with the O-LDL form in tremulous pulse is an ischemia heart disease cause.The free radical oxidant, wherein many come from natural origin for example solar radiation, some nutrient metabolism, physical training or suffer from diabetes through being everlasting in addition and hypertensive patient observable on one's body, play a part LDL is oxidized to its harmful form O-LDL.It is believed that free radical " scavenger " for example vitamin A, E, C and selenium and these oxidant reactions and make them can not oxidation.Thereby the inhibitory action of these antioxidants has suppressed the formation of O-LDL, thereby is reduced in the sedimentary level of blood vessel medium-sized artery speckle.On the contrary, think that the high density lipoprotein (LDL) that exists in vivo has wholesome effect.Say that exactly known HDL is more easily molten lipoprotein form, therefore, it exists for the not significant contribution of the formation of arterial plaque.In addition, known HDL can absorb the speckle material, thereby can directly reduce the amount of arterial plaque.
3. the introduction of prior art
Essential fatty acid (EFAs) is the naturally occurring unsaturated fatty acid that chain length is 18,20 or 22 carbon atoms that has.These fatty acids can not be synthetic by human body, therefore need absorb from food.Two kinds of fatty acids that belong among this class EFAs are 18 carbon 5 alkene acids (EPA) and docosahexenoic acid (DHA), and the two generally is found in the fish oil.Epidemiologic observation shows that fish oil can reduce platelet aggregation and serum triglycerides, thereby can reduce the danger [Gerster of myocardial infarction, hypertension, atherosclerosis and some cancer, H., Internat.J.Vit.Nutr.Res., 65:3-20 (1994)].More precisely, shown that EPA and the DHA from fish oil plays important structure function in the most cells film, and influenced described flowability of cell membranes (Gerster, the same) by reducing whole blood viscosity and the erythrocytic motility of increase and morphotropism.In addition, for example EPA and DHA are the chemical compounds that precursor-a class of known larane class comprises prostaglandin (for example prostaglandin and thromboxane), leukotriene and hydroxy fatty acid to EFAs.Known larane class influences permeability and tonicity, blood pressure and the inflammation immunoreation (Gerster, the same) of platelet aggregation, blood vessel wall.
Known fish oil food supplement has other wholesome effect.Glycogen storage disease is a kind of genetic diseases, frequent concurrent serious hyperlipoproteinemia and hypercholesterolemia, and they have increased the danger of suffering from early atherosclerosis and cardiovascular disease.Reported and taken that triglyceride levels significantly reduces (49%) in its serum of patient of trouble glycogen storage disease that 10 gram fish oil reach 3 months, the cholesterol in serum level significantly reduces (23%) and reduces LDL level (40%) in the serum, and significantly increase HDL level (+30%) [Levy in the serum, E. wait the people, I.Am.J.Clin.Nutr., 57:922-29 (1993)].
Proposed garlic and human body has been had some useful effects as the angiocardiopathy preventing material.For example edible garlic causes reducing lipid level in the human serum, increase the viscosity of the active of fibrinolysis and the former activator of tissue plasminogen (t-PA) and reduction serum fiber, wherein each all can reduce the probability [Brosche that suffers from cardiovascular disease, T. wait the people, British J.Clin.Practice, Supp.69:12-19 (1990); People such as Kiesewetter H., British J.Clin.Practice, Supp.69:24-29 (1990)].In addition, the aggregate level and the reduction peripheral vasodilation of cholesterol and triglyceride are pressed [Auer, people such as W., British J.Clin.Practice, Supp.69:3-6 (1990)] in the known edible garlic reduction human serum.
The secondary metabolite of flavone in edible plants and food, finding from plant.Recognized generally that flavone has antiallergic, antiinflammatory, antiviral, anti-hypertrophy and carcinogenesis activity [Manach, C. wait the people, J.Nutr., 125:1911-22 (1995)].In chromocor compound, have the bioactive flavonol of above-mentioned major part and be present in [Manach, the same] in most of plant.Flavone exists with oxygen glycosides form under natural endowment, generally connects sugar moieties on its 3-position.Rutin is the main glycosides form of Quercetin (the topmost flavonol in fruits and vegetables).
Capsaicin is the Capsicum platymiscium main chemical compositions of (comprising chilli, Fructus Capsici and Fructus Capsici).Capsaicin is actually the alkyl vanillyl amide of a class side chain and straight chain.Since many centuries, known that capsaicin has antibiotic and pain relieving character.In addition, the product that contains capsaicin has been used for treating pain syndrome after rheumatic arthritis, osteoarthritis, neurotic diabetes, postherpetic neuralgia, the mastectomy, cluster headache and alleviation sympathetic nervous syndrome [Cordell, G. and Araujo, O., Ann.Pharm., 27:330-36 (1993)].
Although become known for reducing many compositionss of cardiovascular disease danger, the present invention includes the new compositions of the fish oil, Bulbus Allii, rutin and the capsaicin that reach this purpose.After this manner, still need such can the treating or the new compositions of angiocardiopathy preventing of compositions of the present invention in this area.
The present invention relates to use nutritional supplement composition to overcome the general and normal relevant food deficiency disease of western diet.Obtain compositions of the present invention by mixing fish oil, Bulbus Allii powder, rutin and capsaicin.More precisely, the present invention relates to a kind of daily fish oil preparation of clothes altogether, the preparation that is preferably single fish oil lozenge and is made up of Bulbus Allii powder, rutin and capsaicin is preferably with single lozenge form.
Therefore, the objective of the invention is, the nutrition and the safe compositions of taking for the people are provided to contain the dietary supplement ingredient form of fish oil, Bulbus Allii powder, rutin and capsaicin.
Another purpose provides the new compositions that can increase HDL level in the human serum.
Another purpose of the present invention is for providing the compositions that can reduce O-LDL level in the human serum.
A further object of the present invention is for providing the compositions that can reduce cholesterol and triglyceride levels in the human serum.
The reduction of the increase of HDL and cholesterol and O-LDL should be played the effect of the danger that reduces the human heart disease.Therefore, another object of the present invention is for providing the method for taking compositions of the present invention with the danger of reduction cardiovascular disease by daily.
The daily dose of the present composition is at reducing cardiopathic sickness rate and being grouped into by following one-tenth: (1) fish oil; (2) Bulbus Allii powder; (3) rutin; (4) capsaicin.More precisely, compositions of the present invention is fish oil preparation (preferably with single fish oil lozenge form) and preparation (preferably with single lozenge form, obeying altogether with the fish oil lozenge) be combined into be made up of Bulbus Allii powder, rutin and capsaicin.The preferred weight of described fish oil lozenge is more preferably 1000mg at the about 1500mg of about 500mg-.The preferred weight of described Bulbus Allii lozenge is the about 1000mg of about 400mg-, most preferably from about 700mg.
The fish oil preparation composition of the present composition can buy from the market (Arista, Pharmachem).EPA and DHA are the active substances in the fish oil preparation.The amount that fish oil preparation of the present invention comprises EPA is the about 350mg of about 250mg-, most preferably from about 300mg.The DHA that contains the about 250mg of 150mg-that has an appointment in all the other compositions of described fish oil preparation preferably contains the DHA of the 200mg that has an appointment.The gross weight of fish oil preparation of the present invention is every fish oil lozenge (when with single fish oil lozenge form) about 1500mg of about 500mg-, preferably about 1000mg.
Be used in Bulbus Allii powder in Bulbus Allii powder, rutin and the capsaicin preparation composition of the present composition can buy from the market (Extracts, Ashland, Pure-Gar).In addition, preferably use the Bulbus Allii powder of deodorization and ripening.Be used in pharmaceutically acceptable Bulbus Allii powder in the present composition for by weight, every Bulbus Allii/rutin/capsaicin lozenge (with single lozenge form) comprises the about 700mg of about 100mg-, the more preferably from about about 650mg of 175mg-, the most preferably Bulbus Allii powder of the deodorization of 500mg and ripening.
In Bulbus Allii powder, rutin and the capsaicin preparation composition of the present composition used rutin also can buy from the market (Westco Chemical, Freeman Industries, Inc.).Rutin composition in described Bulbus Allii powder, rutin and the capsaicin preparation contains the about 150mg of about 10mg-, the most preferably from about rutin of 100mg by weight.
The capsaicin that is used in the present composition can have been bought (AllChem, GoodHope Botanicals) from the market.In the time of in being used in Bulbus Allii powder of the present invention, rutin and capsaicin preparation, the capsaicin composition in the present composition contains the about 150mg of about 20mg-, the most preferably from about capsaicin of 100mg by weight.
Bulbus Allii powder, rutin and capsaicin composition are mixed in same preparation.Said preparation and described fish oil preparation are obeyed altogether, and these two kinds of preparations all contain compositions of the present invention.
These preparations can adopt the conventional method preparation.For preparing compositions of the present invention, will mix with suitable carrier as the above-mentioned fish oil of the active component in the immixture and Bulbus Allii powder/rutin/capsaicin preparation according to conventional hybrid technology.Form according to the required preparation of administration is for example oral, Sublingual, intranasal or parenterai administration, and this carrier can use various forms.
In the compositions process of the oral form of preparation, can use any medicinal medium commonly used.With regard to oral liquid (for example suspension, elixir and solution), operable medium comprises for example water, oil, alcohol, flavoring agent, antiseptic, coloring agent etc.Carrier for example starch, sugar, diluent, granulating agent, lubricant, binding agent, disintegrating agent etc. can be used for preparing oral solid formulation (for example powder, capsule, pill, tablet and lozenge).Preferred lozenge is as peroral dosage form.Also can use controlled release form.Because convenient drug administration so lozenge, tablet, pill and capsule are represented best oral dosage unit form, in the case, is obviously used the solid medicinal carrier.As needs, tablet can be for adopting the sugar-coat or the enteric coated tablet of standard technique.
For the example of oral these the additional non-active ingredients that provide of being more convenient for comprises (but being not limited thereto): the Fructus Citri Limoniae bioflavonoids (Botanical International, Freeman), parsley powder, d-alpha tocopherol, Cera Flava, lecithin, gelatin, purified water and glycerol.These chemical compounds can be used in the process of the lozenge for preparing new supplementary.
With regard to non-enteral product, although can comprise other composition (for example being used for hydrotropy and anticorrosion), its carrier generally includes sterilized water.Also the injection suspension can be prepared, in the case, suitable liquid-carrier, suspending agent etc. can be used.
Utilize the lozenge of the preferred method of the present invention for the about 4-8 grain fish oil preparation of user day clothes, 6 these lozenge most preferably from about are in conjunction with the lozenge of taking about 3-5 grain Bulbus Allii powder, capsaicin and rutin preparation, the most preferably lozenge of 4 Bulbus Allii powder, capsaicin and rutin preparations.
The following example illustrates embodiment preferred of the present invention.These embodiment do not mean that any type of restriction to the present invention just in order to illustrate.
Embodiment 1
Measure the influence of the present invention to people's lipid profile.The double-blind study that carries out in the Irvine of University of California medical college shows that utilizing the present invention suitably is that condition has been created in following effect in human serum: (1) significant triglyceride reducing level; (2) remarkable cholesterol reducing and LDL; (3) significantly increase the HDL level.
Record during current research is as follows.Ten experimenters participate in one month by a definite date research, and wherein each experimenter takes ten lozenge every day during this research.Placebo group is taken ten nonactive lozenge and reach one month every day, and the treatment group is taken ten lozenge of the present invention reach one month every day.Each experimenter takes three fish oil lozenge and two Bulbus Allii powder/rutin/capsaicin lozenge (day clothes secondary), day ten lozenge of clothes altogether.The experimenter do not know obey the lozenge characteristic, the trier does not know (being double-blind trial) too.Collect serum (about 4cc) once more after collecting and taking one month in when beginning.Use lipid to separate the quick lipid profile that automatic system (Hewlett-Packard Co.) is carried out plasma sample.In addition, use Chem 18 automated systems (Hewlett-Packard Co.) to measure electrolyte (comprising calcium ion) and glucose level.Use statistical analysis method its result of comparison also is shown in the accompanying drawing 1.
These results show that contrasting plasma triglyceride concentration with blank group reduces by 41%.In addition, cholesterol levels shows reduction by 9%, and reduction by 7% of LDL level and HDL level increase by 17%.
These data are causing that for estimating the present invention the effectiveness that human serum HDL increase and serum cholesterol, triglyceride and low density lipoprotein, LDL (LDL) reduce provides the foundation.
Embodiment 2
The following example provides preferred compositions of the present invention.Provide with two preparations independently: the described compositions of lozenge A (fish oil) and lozenge B (Bulbus Allii, capsaicin and rutin) form.Suitable daily dose is six lozenge A and four lozenge B (in other words, day clothes secondary, each three lozenge A and two lozenge B, totally ten lozenge).
Composition weight lozenge A 1000mg
Fish oil 1000mg lozenge B 700mg
Bulbus Allii powder 487mg
Capsaicin 53mg
Rutin 27mg
Fructus Citri Limoniae bioflavonoids 23mg
Parsley powder 110mg
Embodiment 3
The following example provides preferred compositions of the present invention.Provide with two kinds of preparations independently: the described compositions of lozenge A (fish oil) and lozenge B (Bulbus Allii, capsaicin and rutin) form.Suitable daily dose is six lozenge A and four lozenge B (in other words, day clothes secondary, each three lozenge A and two lozenge B, totally ten lozenge)
Composition weight lozenge A 950mg
Fish oil 950mg lozenge B 700mg
Bulbus Allii powder 600mg
Capsaicin 50mg
Rutin 50mg
Embodiment 4
The following example provides preferred compositions of the present invention.Compositions with the unitary agent form is provided.Proper dosage is secondary every day, each five lozenge.Composition weight fish oil *570mg Bulbus Allii powder 194mg rutin 11mg capsaicin 21mg Fructus Citri Limoniae bioflavonoids 11mg parsley powder 38mgd-alpha tocopherol 5mg Cera Flava 75mg lecithin 75mg gelatin 255mg purified water 10mg glycerol 170mg *EPA in the fish oil: DHA is 300: 200
Many improvement of the present invention and change include in above-mentioned description, and are conspicuous for the person skilled in the art of this area.Thereby the present invention also comprises described compositions and uses described compositions to finish the improvement and the change of its method of the purposes that requires in accessory claim book and analog scope thereof.

Claims (25)

1. the supplementary that comprises fish oil, Bulbus Allii, rutin and capsaicin.
2. the supplementary of claim 1, wherein said fish oil is single fish oil lozenge form.
3. the supplementary of claim 2, wherein said Bulbus Allii, rutin and capsaicin are single Bulbus Allii, rutin and capsaicin lozenge form.
4. the supplementary of claim 1, wherein said fish oil, Bulbus Allii, rutin and capsaicin are single lozenge form.
5. the supplementary of claim 3, wherein said fish oil lozenge is between the about 650mg of about 350mg-.
The supplementary of 6 claim 5, wherein said fish oil lozenge is about 500mg.
7. the supplementary of claim 3, wherein said Bulbus Allii are between the about 700mg of about 200mg-, and rutin is between about 10mg-150mg, and capsaicin is between the about 150mg of about 20mg-.
8. the supplementary of claim 7, wherein said fish oil is about 500mg, and Bulbus Allii is about 500mg, and rutin is about 100mg, and capsaicin is about 100mg.
9. the supplementary of claim 7, wherein said fish oil is about 500mg, and Bulbus Allii is about 275mg, and rutin is about 135mg, and capsaicin is about 90mg.
10. the supplementary of claim 7, wherein said fish oil is about 600mg, and Bulbus Allii is about 200mg, and rutin is about 10mg, and capsaicin is about 20mg.
11. the supplementary of claim 3, wherein said Bulbus Allii, rutin and capsaicin lozenge are between the about 650mg of about 350mg-.
12. the supplementary of claim 7, wherein said Bulbus Allii, rutin and capsaicin lozenge are about 500mg.
13. the supplementary of claim 3, the gross weight of wherein said fish oil and Bulbus Allii, rutin and capsaicin lozenge is between the about 1300mg of about 700mg-.
14. the supplementary of claim 13, the gross weight of wherein said fish oil and Bulbus Allii, rutin and capsaicin lozenge is about 1000mg.
15. the supplementary of claim 1, wherein said fish oil comprises the EPA of the about 350IU of about 250IU-.
16. the supplementary of claim 15, wherein said fish oil comprises the EPA of about 300IU.
17. the supplementary of claim 1, wherein said fish oil comprises the DHA of the about 250IU of about 150IU-.
18. the supplementary of claim 17, wherein said fish oil comprises the DHA of about 200IU.
19. the supplementary of claim 1, wherein said Bulbus Allii are the Bulbus Allii powder form.
20. prepare the method for supplementary of the present invention, it comprises mixes described fish oil, Bulbus Allii, rutin and capsaicin composition with suitable carriers.
21. the method for HDL level in the increase human plasma, it comprises the supplementary that gives claim 3 or claim 4 every day.
22. the method for O-LDL, cholesterol and triglyceride in the reduction human plasma, it comprises the supplementary that gives claim 3 or claim 4 every day.
23. the method for claim 21, wherein said daily dose are to comprise about 8 fish oil lozenge of about 4-and about 5 Bulbus Allii, rutin and the capsaicin lozenge of about 3-.
24. the method for claim 22, wherein said daily dose are to comprise about 8 fish oil lozenge of about 4-and about 5 Bulbus Allii, rutin and the capsaicin lozenge of about 3-.
25. the method for claim 23 or claim 24, wherein said daily dose are to comprise about 6 fish oil lozenge and about 4 Bulbus Allii, rutin and capsaicin lozenge.
CN96195324A 1996-03-12 1996-06-17 Fish oil and garlic nutritive composition Pending CN1190347A (en)

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US2517396P 1996-03-12 1996-03-12
US60/025,173 1996-03-12

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101103966B (en) * 2006-07-14 2010-11-03 上海展望科技有限公司 Omega-3 falty acid-garlic oil capsule and manufacturing method thereof
CN104208454A (en) * 2014-06-30 2014-12-17 江苏伟楼生物科技有限公司 Garlic oil softgel and preparation method thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000019717A (en) * 1998-09-15 2000-04-15 박호군 Composition comprising rutin and quercetin for preventing and treating hyperlipidemia, arteriosclerosis and liver disease
KR20030080340A (en) * 2002-04-08 2003-10-17 주식회사 엔바이오제네시스 Manufacture method of diet food involving capsicin
FR2849992B1 (en) * 2003-01-17 2007-03-16 Inst Phytoceutic COMPOSITION FOR ORAL ADMINISTRATION CONTAINING CAPSAICINOIDS
EP1902723B1 (en) * 2006-09-19 2009-07-08 Jürgen Prof. Dr. Schrezenmeir Sabal fruit or Sabal oil as lipase inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1148206B (en) * 1963-12-23 1986-11-26 Medicinali D U R S T Srl Fab Rutine vitamin e deriv complexes
DE3520761A1 (en) * 1984-06-11 1985-12-12 Ajinomoto Co., Inc., Tokio/Tokyo USE OF VANILLYLAMINE OR VANILLYLAMIDES TO PROMOTE FAT METABOLISM
JPS6211079A (en) * 1985-07-08 1987-01-20 Nobutsugu Kimura Compounded food good for blood vessel system
JPH0817673B2 (en) * 1991-08-06 1996-02-28 卓蔵 松山 Activated garlic paste, method for producing the same, and foods using the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101103966B (en) * 2006-07-14 2010-11-03 上海展望科技有限公司 Omega-3 falty acid-garlic oil capsule and manufacturing method thereof
CN104208454A (en) * 2014-06-30 2014-12-17 江苏伟楼生物科技有限公司 Garlic oil softgel and preparation method thereof

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EP0835119A4 (en) 1998-08-26
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AU6282796A (en) 1997-10-01

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