CN1189207C - Chinese medicinal composition for improving human immunity and its preparation method - Google Patents
Chinese medicinal composition for improving human immunity and its preparation method Download PDFInfo
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- CN1189207C CN1189207C CN 03146128 CN03146128A CN1189207C CN 1189207 C CN1189207 C CN 1189207C CN 03146128 CN03146128 CN 03146128 CN 03146128 A CN03146128 A CN 03146128A CN 1189207 C CN1189207 C CN 1189207C
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Abstract
The present invention discloses traditional Chinese medicine composition for improving the immunity of a human body. The present invention uses astragalus root, Atractylodes macrocephala, ledebouriella root and american ginseng as raw materials, according to different properties of each kind of the traditional Chinese medicine, each kind of the traditional Chinese medicine is processed by pulverizing, etc. and is proportionally prepared so as to prepare various preparations with a carrier or excipient accepted by pharmacy. The present invention has the advantages of unique prescription and preparation method, conspicuous effects and no toxic side effects.
Description
[technical field]
The present invention relates to a kind of Chinese medicine composition that improves body immunity, and the preparation method of this Chinese medicine composition.
[background technology]
Because immunity of organisms is low, causes clinical common diseases such as recurrent respiratory tract infection easily, and is mainly in old people and child.China's Chinese medicine and pharmacy always just takes much count of preventive medicine, be referred to as meaning " preventive treatment of disease ", a kind of Chinese medicine that improves body immunity commonly used clinically now is made up of the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae three herbal medicines, cure mainly spontaneous perspiration, these Chinese crude drug composition weight in grams numbers need be looked the different and an amount of plus-minuss different with the state of an illness of patient's difference, disease of treatment.And by modern medicine study, its prescription is warm-dryness syndrome relatively.
[summary of the invention]
Technical problem to be solved
The Chinese medicine composition that the purpose of this invention is to provide a kind of evident in efficacy and raising body immunity of having no side effect.It is according to the Chinese medicine and pharmacy theory, the medicine that adopts the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Radix Panacis Quinquefolii to be processed into through the science compatibility as raw material, and this medicine production technology is simple, be easy to take, effect is remarkable, is a kind of medicine of ideal raising body immunity.Simultaneously, another object of the present invention provides a kind of preparation method of this Chinese medicine composition.
Technical scheme
The object of the present invention is achieved like this:
The Chinese medicine composition that the present invention improves body immunity is to be made by the raw material of Chinese medicine that comprises following weight parts:
Radix Astragali 50-80 part Rhizoma Atractylodis Macrocephalae 10-40 part Radix Saposhnikoviae 10-40 part
Radix Panacis Quinquefolii 1-5 part
The preferred weight proportioning of preparation Chinese medicine composition of the present invention is:
20 parts of 20 parts of Radix Saposhnikoviaes of 60 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Astragali
3 parts of Radix Panacis Quinquefoliis
The source of the Chinese crude drug that technique scheme is mentioned is as follows:
The Radix Astragali: the dry root of the leguminous plant Radix Astragali.Invigorating QI to consolidate the body surface resistance is arranged, the diuresis poison holding, evacuation of pus, the effect of sword skin ulcer granulation promoting, it is weak to be used for the deficiency of vital energy.
The Rhizoma Atractylodis Macrocephalae: the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Invigorating the spleen and benefiting QI is arranged, the dampness diuretic, hidroschesis, antiabortive effect is used for insufficiency of the spleen lack of appetite, and abdominal distention is had loose bowels.
Radix Saposhnikoviae: the dry rhizome of umbelliferae Saposhnikovia divaricata.Inducing diaphoresis to dispel wind is arranged, win and wet, the effect of relieving convulsion is used for headache due to common cold.
Radix Panacis Quinquefolii: be the dry root of Araliaceae Radix Panacis Quinquefolii.Boosting qi and nourishing yin is arranged, the effect of clearing away heat and promoting production of body fluid
Chinese medicine composition of the present invention can prepare according to following three kinds of methods:
First method, it comprises the following steps: to take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Above-mentioned Chinese crude drug is dried and crushed into fine powder, sieves, again that whole fine powders are even by described mixed, packing makes.
Second method, it comprises the following steps: to take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Above-mentioned pulverizing medicinal materials is become coarse powder, with 50-60 weight % ethanol be solvent 60-70 ℃ of reflux, extract,, extracting solution becomes thick extractum at cryoconcentration again after removing ethanol, drying is ground into fine powder, sieves, with whole fine powder mix homogeneously, packing makes again.
The third method, it comprises the following steps: to take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Decoct with water 2-3 hour, decoct with water 1-2 hour after the filtration again, filter then, merging filtrate leaves standstill clarification, and low-temperature evaporation is concentrated into the thick paste shape, the ratio of thick paste should be 1.30-1.35 80-90 ℃ of hot down the survey, the thick paste active component mix homogeneously that obtains like this, and packing makes.
Above-mentioned prescription of the present invention can directly be pulverized or be refining as the active component for the treatment of children's cold, heating Chinese medicine composition through the extraction of the conventional extractive technique in this area such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation.Described active component can be made various pharmaceutical formulations such as powder, tablet, oral liquid, granule, injection, capsule or the like with pharmaceutically acceptable carrier or excipient composition.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
Beneficial effect
Pharmaceutical composition of the present invention has benefiting QI for strengthening the superficies, the effect of human body immunity improving power, and medicine of the present invention is not warm not dry, and reinforcing both QI and YIN to deficiency of vital energy disease repeated cold patient, has significant curative effect.And, be increased to usual amounts and show for 200 times and have no side effect through acute and long term toxicity test.This medicine production technology is simple, be easy to take, evident in efficacy, be a kind of medicine of ideal raising body immunity.
[specific embodiment]
Below in conjunction with specific embodiment and test example the present invention is elaborated.
Embodiment 1: the preparation of capsule
20 parts of 20 parts of Radix Saposhnikoviaes of 60 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Astragali
3 parts of Radix Panacis Quinquefoliis
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Above-mentioned Chinese crude drug is dried and crushed into fine powder, sieves, be mixed, the hard capsule case of packing into.
Embodiment 2: the preparation of capsule
20 parts of 20 parts of Radix Saposhnikoviaes of 60 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Astragali
3 parts of Radix Panacis Quinquefoliis
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Above-mentioned pulverizing medicinal materials is become coarse powder, with 50-60% ethanol be solvent 60-70 ℃ of reflux, extract,, extracting solution is after removing ethanol, cryoconcentration becomes thick extractum, drying is ground into fine powder, sieves, and is mixed, the hard capsule case of packing into.
Embodiment 3: the preparation of capsule
20 parts of 20 parts of Radix Saposhnikoviaes of 60 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Astragali
3 parts of Radix Panacis Quinquefoliis
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Decoct with water 2-3 hour, decoct with water 1-2 hour after the filtration again, filter then, merging filtrate leaves standstill clarification, low-temperature evaporation is concentrated into the thick paste shape, the ratio of thick paste should be 1.30-1.35 80-90 ℃ of hot down the survey, and above-mentioned thick paste is dried and crushed into fine powder, sieves, behind the mix homogeneously, the hard capsule case of packing into.
Embodiment 4: the preparation of powder
20 parts of 20 parts of Radix Saposhnikoviaes of 60 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Astragali
3 parts of Radix Panacis Quinquefoliis
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Decoct with water twice, 2-3 hour for the first time, 1-2 hour for the second time, filter, merging filtrate leaves standstill clarification, and low-temperature evaporation is concentrated into the thick paste shape, and the ratio of thick paste should be 1.30-1.35 80-90 ℃ of hot down the survey, above-mentioned thick paste is dried and crushed into fine powder, sieves, be mixed, packing is made.
Embodiment 5: the preparation of tablet
20 parts of 20 parts of Radix Saposhnikoviaes of 60 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Astragali
3 parts of Radix Panacis Quinquefoliis
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Above-mentioned pulverizing medicinal materials is become coarse powder, with the ethanol of 50-60% be solvent 60-70 ℃ of reflux, extract,, extracting solution is after removing ethanol, cryoconcentration becomes thick extractum, drying is ground into fine powder, sieves, and is mixed, and granulates, compacting is made in flakes.
The characteristics of medicine of the present invention are: it is low significantly to improve immune function of human body, and little to the human body side effect, to lung qi deficient syndrome repeated cold patient, has remarkable result.Through clinical observation 181 examples, improvement rate always reaches 89.5%, and whole structure is good.Specifically see as follows.
Test example 1: thing of the present invention is to improving the clinical efficacy materials and methods of immune function of human body:
1, object of study:
The child: immunologic hypofunction, easy catching a cold, every month more than twice, or the above patient that suffers from an inflammation of the lungs in a year twice.
Elderly patients: suffer from multiple chronic disease, be diagnosed as the patient of syndrome of deficiency of lung qi.
2, the method for administration and the course of treatment:
Oral embodiment of the invention capsule
The adult: each 3, every day 3 times.
Child below 6 years old: each 1, every day 2-3 time.
Child more than 6 years old: each 2, every day 2-3 time.
Above patient was a course of treatment with one month all, and it treats 1-3 the course of treatment.
3, observational technique:
Carry out blood, urine, just routine test and the heart, pulmonary function test, and observe: heating, aversion to cold, sniffle, pharyngeal symptom and whole body situation and the temperature of having a medical check-up, pharyngeal tonsil, the picture of the tongue pulse condition, therapeutic evaluation is carried out in variations such as fingerprint respectively.
4, therapeutic evaluation
Observe 181 routine patients altogether, wherein obviously improve 141 examples, account for 77.9%; Improve 21 examples, account for 11.6%, invalid 19 examples account for 10.5, improvement rate always 89.5%.See Table one.
Table one prescription of the present invention improves the clinical observation of immune function of human body
| The example number | Obviously improve | Improve | Invalid | Total improvement rate % |
| 181 | 141 | 21 | 19 | 89.5 |
Drug side effect of the present invention: period in a medicine small number of patients xerostomia, outside the dry stool, all there is not any untoward reaction, drug withdrawal or decrement, xerostomia, dry stool transference cure.
Test example 2: thing of the present invention is to the clinical efficacy of lung qi deficient syndrome
To syndrome of deficiency of lung qi,, carry out clinical efficacy relatively with 160 routine patients:
Wherein: thing group of the present invention: 120 people, take embodiment of the invention capsule
Matched group: 40 people, take and be pantocrine,
The method of administration and the course of treatment:
Thing group of the present invention: adult: each 3, every day 3 times.
Child below 6 years old: each 1, every day 2-3 time.
Child more than 6 years old: each 2, every day 2-3 time.
Above patient was a course of treatment with one month all, and it treats 1-3 the course of treatment.
Matched group method of administration: each 10ml, every day 2 times.Taking one month is a course of treatment, and it treats 1-3 the course of treatment.
Clinical effectiveness sees Table two.
Table two prescription of the present invention is to the comparison of syndrome of deficiency of lung qi clinical efficacy
| Group | Total routine number | Recovery from illness % | Produce effects % | Effective % | Invalid % | Total effective rate % |
| Of the present invention group | 120 | 27 | 36 | 53 | 4 | 116 |
| Matched group | 40 | 2 | 10 | 22 | 6 | 34 |
Result of the test shows that thing of the present invention has remarkable result to lung qi deficient syndrome repeated cold patient's treatment.
Test example 3, thing of the present invention are to the effect experiment of animal
1, experiment material:
(1) animal: healthy male Kunming kind white mice.
(2) medicine: thing of the present invention, and pantocrine
2, experimental technique:
Get 90 white mice, be divided into 9 groups at random, 10 every group, control group administered physiological saline, the pantocrine group is given the Cornu Cervi Pantotrichum seminal fluid, and the contrivance group is given thing of the present invention.Once a day, continuous irrigation stomach 7 days, it is identical that each group is irritated stomach, treats that the last administration puts to death all animals after 24 hours, and postmortem is also cutd open and is got main organs and do histological examination.
3, result of the test:
Normal white mice spleen weight is had tangible proliferative effect, thymus is not then had remarkable proliferative effect, but to the spleen of immunosuppressed mice, thymus all there is significant proliferative effect.Pathology section examination is respectively organized equal no change.See table three, table four and table five for details
Table three prescription of the present invention is to the influence of white mice spleen, thymus
| Group | Number of animals (only) | Spleen (mg/10g body weight) | Thymus (mg/10g body weight) |
| Matched group | 10 | 50.1 | 33.5 |
| The Cornu Cervi Pantotrichum group | 10 | 67.3 | 42.3 |
| Thing group of the present invention | 10 | 65.2 | 38.5 |
Table four prescription of the present invention is to the influence of immunosuppressed mice spleen, thymus
| Group | Number of animals (only) | Spleen (mg/10g body weight) | Thymus (mg/10g body weight) |
| Matched group | 10 | 40.5 | 30.9 |
| The Cornu Cervi Pantotrichum group | 10 | 53.5 | 38.8 |
| Thing group of the present invention | 10 | 54 | 37.8 |
The influence of table five couple T, bone-marrow-derived lymphocyte classification
| Group | Number of animals (only) | T lymphocyte (%) | Bone-marrow-derived lymphocyte (%) |
| Matched group | 10 | 60.65 | 39.35 |
| The Cornu Cervi Pantotrichum group | 10 | 53.23 | 46.77 |
| Thing group of the present invention | 10 | 52.59 | 47.41 |
Be significantly improved by the immunity of the visible thing of the present invention of above data to animal.
Claims (7)
1, a kind of Chinese medicine composition that improves body immunity is characterized in that the preparation raw material of its contained active component is as follows in weight portion:
Radix Astragali 50-80 part Rhizoma Atractylodis Macrocephalae 10-40 part Radix Saposhnikoviae 10-40 part
Radix Panacis Quinquefolii 1-5 part
2, Chinese medicine composition according to claim 1 is characterized in that described preparation raw material is as follows in weight portion:
20 parts of 20 parts of Radix Saposhnikoviaes of 60 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Astragali
3 parts of Radix Panacis Quinquefoliis
3, Chinese medicine composition according to claim 1 and 2, the dosage form that it is characterized in that it are powder, capsule, tablet, granule, pill or oral liquid.
4, Chinese medicine composition according to claim 3, the dosage form that it is characterized in that it is a capsule.
5,, it is characterized in that it comprises the following steps: according to the preparation method of claim 1 or 2 described Chinese medicine compositions
A) take by weighing raw materials of traditional Chinese medicinal materials according to claim 1 or 2 described consumptions;
B) above-mentioned Chinese crude drug is dried and crushed into fine powder, sieves, again that whole fine powders are even by described mixed, packing makes.
6,, it is characterized in that it comprises the following steps: according to the preparation method of claim 1 or 2 described Chinese medicine compositions
A) take by weighing raw materials of traditional Chinese medicinal materials according to claim 1 or 2 described consumptions;
B) above-mentioned pulverizing medicinal materials is become coarse powder, with 50-60% ethanol be solvent 60-70 ℃ of reflux, extract,, extracting solution becomes thick extractum at cryoconcentration again after removing ethanol, drying is ground into fine powder, sieves, with whole fine powder mix homogeneously, packing makes again.
7,, it is characterized in that it comprises the following steps: according to the preparation method of claim 1 or 2 described medicines
A) take by weighing raw materials of traditional Chinese medicinal materials according to claim 1 or 2 described consumptions;
B) decoct with water 2-3 hour, decoct with water 1-2 hour after the filtration again, filter then, merging filtrate leaves standstill clarification, and low-temperature evaporation is concentrated into thick paste, the ratio of thick paste should be 1.30-1.35 80-90 ℃ of hot down the survey, the thick paste active component mix homogeneously that obtains like this, and packing makes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03146128 CN1189207C (en) | 2003-07-24 | 2003-07-24 | Chinese medicinal composition for improving human immunity and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03146128 CN1189207C (en) | 2003-07-24 | 2003-07-24 | Chinese medicinal composition for improving human immunity and its preparation method |
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| Publication Number | Publication Date |
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| CN1478530A CN1478530A (en) | 2004-03-03 |
| CN1189207C true CN1189207C (en) | 2005-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 03146128 Expired - Lifetime CN1189207C (en) | 2003-07-24 | 2003-07-24 | Chinese medicinal composition for improving human immunity and its preparation method |
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| CN (1) | CN1189207C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103735642A (en) * | 2014-01-19 | 2014-04-23 | 李爱辉 | Traditional Chinese medicine for preventing influenza |
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| CN1478530A (en) | 2004-03-03 |
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Owner name: TONGYAO GROUP DATONG PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: DATONG PHARMACEUTICAL CO., LTD., OF YABAO PHARMACY |
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Address after: 037043 No. 2 Kaiyuan street, Datong South Road, Datong, Shanxi Patentee after: TONGYAO GROUP DATONG PHARMACEUTICAL Co.,Ltd. Address before: 037043 No. 2 Kaiyuan street, Datong South Road, Datong, Shanxi Patentee before: YABAO PHARMACEUTICAL DATONG PHARMACEUTICAL CO.,LTD. |
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Address after: 037000 first pharmaceutical industry zone, Datong Development Zone, Shanxi, Datong Patentee after: Guangsheng Yuanzhong Pharmaceutical Co.,Ltd. Address before: 037043 No. 2 Kaiyuan street, Datong South Road, Datong, Shanxi Patentee before: TONGYAO GROUP DATONG PHARMACEUTICAL Co.,Ltd. |
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Granted publication date: 20050216 |