CN1053381C - Drug for promoting puerperal physiological recovery and curing postpartum disease - Google Patents
Drug for promoting puerperal physiological recovery and curing postpartum disease Download PDFInfo
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- CN1053381C CN1053381C CN97100156A CN97100156A CN1053381C CN 1053381 C CN1053381 C CN 1053381C CN 97100156 A CN97100156 A CN 97100156A CN 97100156 A CN97100156 A CN 97100156A CN 1053381 C CN1053381 C CN 1053381C
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Abstract
The present invention relates to a postpartum medical health-care medicine suitable for women. The medicine uses a medical composition prepared from chuanxiong rhizome, Chinese angelica, milkvetch root, tuber fleeceflower root and prepared dried ginger as the effective component to prepare preparations in various medicament forms. The medicine has the functions of promoting the postpartum physiological involution of women, improving the postpartum defense function of an organism and treating various postpartum diseases.
Description
The present invention relates to the medicine of a kind of postpartum health care and treatment puerperal disease, be specifically a kind of be the Chinese patent medicine that feedstock production forms with the Chinese herbal medicine, have the effect that promotes that puerperium physiology returns to the past, improves body defense function in puerperal, can be used for treating various puerperal diseases.Belong to the field of Chinese medicines.
One of puerperal disease is a harm body of women health, even life-threatening key factor.Although China's health care level improves constantly, but, rate of maternal deaths does not still obviously descend at present, according to statistics, the conceived childbirth of annual nearly 2,500 ten thousand people of the national women of child-bearing age, the women who accepts the abortion has tens million of person-times again, therefore, perform the health-care recovery work of puerperal (comprising induced labor and post-abortion),, improve the human quality and have great importance for the health key health that ensures numerous women and children.The traditional Chinese medical science is thought, postpartum women goes out hyperhematosis, the impairment of body fluid exhaustion of blood, blood-stasis internal-depression, disorder of QI movement, vigour is impaired, the turbid liquid of surplus blood is not to the greatest extent, multiple disease occurs easily, for example, take place easily that the involution of uterus is bad, diseases such as abdominal muscular relaxation, postpartum hemorrhage, retention of lochia, prolonged lochiorrhea, puerperal waist stomachache, puerperal spontaneous sweating, constipation, hypogalactia.Modern medicine experimentation and clinical observation prove that puerperal, body's immunity was low, and resistance against diseases is poor, the blood viscosity height, and coagulability is strong, is easy to gather, so at the susceptible disease in puerperal, influence the recovery of normal physiological function.For this reason, be necessary to allow maternity clothing with certain health medicine, promote the recovery of its physiological function, reach the purpose of preventing and curing diseases in puerperal.Yet the present health care medicine that also lacks women's postpartum health care aspect particularly promotes postpartum recovery of women and the medicine for the treatment of puerperal disease, and is very few for number especially.
The purpose of this invention is to provide the Chinese patent medicine that a kind of women's of promotion physiology in puerperal returns to the past, improves body defense function in puerperal.This medicine has and promotes uterine contraction and the inflammation effect of disappearing in puerperal.
The principles of formulating prescriptions of medicine of the present invention are that tonify deficiency is set upright, blood stasis dispersing and fresh blood promoting, as theoretical foundation, form prescription, are prepared into medicine.
Therefore, the composition of pharmaceutical composition of the present invention is by weight as follows:
Rhizoma Chuanxiong 100-300 weight portion
Radix Angelicae Sinensis 100-300 weight portion
Radix Astragali 200-500 weight portion
Radix Polygoni Multiflori 200-500 weight portion
Rhizoma Zingiberis Preparatum 50-150 weight portion
The preferred weight proportioning of pharmaceutical composition of the present invention is:
Rhizoma Chuanxiong 100-200 weight portion
Radix Angelicae Sinensis 100-200 weight portion
Radix Astragali 200-400 weight portion
Radix Polygoni Multiflori 200-400 weight portion
Rhizoma Zingiberis Preparatum 50-120 weight portion
The optimum weight proportioning of pharmaceutical composition of the present invention is:
Rhizoma Chuanxiong 150 weight portions
Radix Angelicae Sinensis 150 weight portions
The Radix Astragali 300 weight portions
Radix Polygoni Multiflori 300 weight portions
Rhizoma Zingiberis Preparatum 90 weight portions
Radix Polygoni Multiflori in the aforementioned pharmaceutical compositions preferably uses Radix Polygoni Multiflori Preparata.
Aforementioned pharmaceutical compositions of the present invention can be prepared into any pharmaceutical preparation that is suitable for using clinically according to the process of Chinese medicine preparation of routine; for example; tablet; powder; capsule; pill; unguentum; oral liquid; the parenterai administration dosage form; for example; injection; patch; liniment; suppository etc. are as long as used pharmaceutical composition of the present invention, no matter adopt which kind of dosage form; all belong within protection scope of the present invention; when aforementioned pharmaceutical compositions is prepared into medicament,, can add other excipient again according to the special requirement of preparation; for example; flavoring agent, solubilizing agent, diluent etc.
The preferred dosage form of the present invention is peroral dosage form, particularly oral liquid, can also add various excipient when the preparation oral liquid, for example, and brown sugar, white sugar, tween 80, citric acid, tartaric acid and essence etc.
The preparation method of oral liquid of the present invention is:
According to aforementioned pharmaceutical compositions and proportioning thereof choose raw material, get Rhizoma Chuanxiong, Radix Angelicae Sinensis adds water 8-12 and doubly measures, preferred 10 times of amounts, soaked 0.5-2 hour, the preferred immersion 1 hour, reflux, extract, 20-40 minute, preferred 30 minutes, collect volatilization profit and aqueous solution, the Aromatic water of collecting device is in addition preserved, and cold preservation is placed standby; Medicinal residues and remaining Radix Astragali, the Radix Polygoni Multiflori, Rhizoma Zingiberis Preparatum three flavors add water 5-10 doubly to be measured, and preferably adds 8 times of water gagings, decocts twice, and each decocting time 0.5-2 hour, preferred decocting time 1 hour, collecting decoction filters, and medicinal residues are abandoned; Filtrate is concentrated into relative density 1.21-1.25 (70-80 ℃), filterable while hot extractum, and device is preserved standby in addition.
1-2 by clear paste is doubly measured brown sugar, adds 50% water boil after the chopping, filters, and filtrate adds the citric acid of 0.1-0.5%, keeps about 102-105 ℃ of temperature, and is time 1-3 hour, preferred 2 hours, standby.
1-1.5 by clear paste is doubly measured white sugar, adds 50% water boil 20-40 minute, and preferred 30 minutes, add the tartaric acid of 0.05-0.15%, stir evenly, keep little and boil about temperature 102-110 ℃, time 1-3 hour, preferred 2 hours, standby.
With above-mentioned clear paste, refining brown sugar and refining white sugar mixing, boil,, place when above to relative density 1.070, be chilled to below 60 ℃, add the Aromatic water of the above-mentioned preparation of using the tween 80 solubilising and the flavoring pineapple essence of total amount 0.1%, stir evenly, fill, promptly.
Medicine of the present invention has the restoration of old ways of promotion women physiology in puerperal, raising body defense function in puerperal, promotion uterine contraction in puerperal and inflammation and disappears, alleviates the hyperemia in uterus in puerperal and the effect of edema and promotion hemopoietic function.
The Expermental research on main pharmacodynamics result of medicine of the present invention is as follows:
(1) to the influence of rabbit isolated uterine
By the contraction of physiograph observation isolated uterine, the result shows: medicine of the present invention and SHENGHUATANG effect are similar, and isolated uterine is all had tangible excitation.
(2) to the influence of rabbit in the body uterus
Observe contraction in the body uterus by physiograph, the result shows: under Isodose, medicine of the present invention and SHENGHUATANG all have appreciable stimulating action to the uterus, but the effect of medicine of the present invention is obviously greater than SHENGHUATANG, and contractility is stronger.
(3) medicine of the present invention is to the influence in rat uterus in puerperal
24 of healthy Wistar kind rat, body weight 260.1 ± 49.9 grams, 17 of pregnant Mus, 7 of normal female Mus, treat that pregnant Mus is divided into three groups puerperal at random, gavage the medicine of the present invention of 15 times of people's consumptions respectively, SHENGHUATANG solution and equal-volume normal saline, once a day, serve on 5 days, after the last administration 24 hours, each two treated animal of sacrificed by decapitation, anatomic observation uterus color and luster, litter size, the variation of uterus transverse diameter and uterus weight, the result shows: medicine of the present invention and SHENGHUATANG can make the hyperemia in uterus in puerperal being equal under the dosage, edema alleviates, it is more obvious that medicine of the present invention alleviates degree, is being better than SHENGHUATANG aspect the restoration of old ways that promotes the uterus.
(4) medicine of the present invention is to the influence of mice uterine cancer cell in puerperal form
The result shows: in 72 hours, the 84 hours treated animals after taking medicine of the present invention and SHENGHUATANG ball, blood capillary hyperemia obviously alleviates under the puerperal uterine mucosa; Gavage puerperal behind medicine of the present invention and the SHENGHUATANG ball visible hemorrhagely obviously alleviate of group in 16 hours puerperal, alleviate with matched group is apparent in view; The downright bad situation of Placenta Hominis attachment surface is similar in 36 hours groups medicine of the present invention and SHENGHUATANG effect; Inflammatory cell infiltration degree medicine medication of the present invention group alleviates than matched group is obvious.
(5) influence of medicine pair cell of the present invention immunity
Medicine of the present invention gavaged mice 5 days continuously, and periphery blood T lymphocyte is obviously risen, and with the increasing effect enhancing of dosage, can promote the pouring rate of rotation when 30 times of adult's consumptions.
(6) influence that mouse anti endotoxin antibody is produced
Medicine of the present invention all can obviously promote the effect that mouse anti endotoxin antibody produces under heavy dose of (30 times of people's consumptions) and low dose of (15 times), and with the increase effect enhancing of dosage, heavy dose of group compares with small dose group, and heavy dose of group of effect is stronger.
(7) to the influence of losing blood property " blood deficiency " mouse red blood cell, hematochrome
The result shows: medicine of the present invention has the effect that promotes hemopoietic function.
Medicinal application of the present invention is in clinical, help women's reposition of the womb in puerperal, alleviate hyperemia, edema and the inflammation in uterus, concerning postpartum women, it is a kind of well-adapted health therapy medicine, if multiple pathological changes puerperal appears in the women, take medicine of the present invention and can alleviate and cure multiple common puerperal disease, as prolonged lochia, inflammation etc.
Embodiment 1
Rhizoma Chuanxiong 150 grams
Radix Angelicae Sinensis 150 grams
The Radix Astragali 300 grams
Radix Polygoni Multiflori 300 grams
Rhizoma Zingiberis Preparatum 90 grams
Brown sugar 600 grams
White sugar 400 grams
6 milliliters of tween 80s
Citric acid 1.8 grams
Tartaric acid 0.4 gram
1 milliliter of flavoring pineapple essence
Get Rhizoma Chuanxiong, Radix Angelicae Sinensis adds 10 times of amounts of water, soaks 1 hour, reflux, extract, 30 minutes is collected volatilization profit and aqueous solution, the Aromatic water of collection device is in addition preserved, cold preservation is placed standby; Medicinal residues and remaining Radix Astragali, the Radix Polygoni Multiflori, Rhizoma Zingiberis Preparatum three flavors add 8 times of water gagings of water, decoct twice, each decocting time 1 hour, and collecting decoction filters, and medicinal residues are abandoned; Filtrate is concentrated into relative density 1.21 (70-80 ℃), filterable while hot extractum, and device is preserved standby in addition.
Get brown sugar, add 50% water boil after the chopping, filter, filtrate adds 0.3% citric acid, keeps 102-105 ℃ of temperature, and is 2 hours time, standby.
Get white sugar, added 50% water boil 30 minutes, add 0.1% tartaric acid, stir evenly, keep little 105 ℃ of temperature of boiling, 2 hours time, standby.
With above-mentioned clear paste, refining brown sugar and refining white sugar mixing, boil, to relative density 1.070 when above, placement, be chilled to below 60 ℃, add the Aromatic water of the above-mentioned preparation of using the tween 80 solubilising and the flavoring pineapple essence of total amount 0.1, stir evenly, make 1000 milliliters, fill, promptly.
Embodiment 2
Rhizoma Chuanxiong 100 grams
Radix Angelicae Sinensis 100 grams
The Radix Astragali 300 grams
Radix Polygoni Multiflori 200 grams
Rhizoma Zingiberis Preparatum 50 grams
Brown sugar 600 grams
Get Rhizoma Chuanxiong, Radix Angelicae Sinensis adds 10 times of amounts of water, soaks 1 hour, reflux, extract, 30 minutes is collected volatilization profit and aqueous solution, the Aromatic water of collection device is in addition preserved, cold preservation is placed standby; Medicinal residues and remaining Radix Astragali, the Radix Polygoni Multiflori, Rhizoma Zingiberis Preparatum three flavors add 8 times of water gagings of water, decoct twice, each decocting time 1 hour, and collecting decoction filters, and medicinal residues are abandoned; Filtrate is concentrated into relative density 1.21 (70-80 ℃), and filterable while hot extractum adds above-mentioned Aromatic water, brown sugar and appropriate amount of starch, and mix homogeneously is made granule, and drying obtains granule.
Claims (8)
1. medicine for the treatment of puerperal disease is characterized in that it is made by following raw materials according:
Rhizoma Chuanxiong 100-300 weight portion
Radix Angelicae Sinensis 100-300 weight portion
Radix Astragali 200-500 weight portion
Radix Polygoni Multiflori 200-500 weight portion
Rhizoma Zingiberis Preparatum 50-150 weight portion.
2. medicine according to claim 1 is characterized in that it is made by following raw materials according:
Rhizoma Chuanxiong 100-200 weight portion
Radix Angelicae Sinensis 100-200 weight portion
Radix Astragali 200-400 weight portion
Radix Polygoni Multiflori 200-400 weight portion
Rhizoma Zingiberis Preparatum 50-120 weight portion.
3. medicine according to claim 2 is characterized in that it is made by following raw materials according:
Rhizoma Chuanxiong 150 weight portions
Radix Angelicae Sinensis 150 weight portions
The Radix Astragali 300 weight portions
Radix Polygoni Multiflori 300 weight portions
Rhizoma Zingiberis Preparatum 90 weight portions.
4. according to claim 1 or 2 or 3 described medicines, it is characterized in that described Radix Polygoni Multiflori is a Radix Polygoni Multiflori Preparata.
5. according to claim 1 or 2 or 3 described medicines, it is characterized in that the pharmaceutical dosage form of its preparation is an oral formulations.
6. medicine according to claim 4 is characterized in that also containing the medicine excipient.
7. medicine according to claim 5 is characterized in that described medicine excipient is any in brown sugar, white sugar, tween, citric acid, tartaric acid, the essence or more than one combination.
8. one kind is used for the medicine that the women takes puerperal, it is characterized in that it is the medicament that forms with following raw material and prepared:
Rhizoma Chuanxiong 150 grams
Radix Angelicae Sinensis 150 grams
The Radix Astragali 300 grams
Radix Polygoni Multiflori Preparata 300 grams
Rhizoma Zingiberis Preparatum 90 grams
Brown sugar 600 grams
White sugar 400 grams
6 milliliters of tween 80s
Citric acid 1.8 grams
Tartaric acid 0.4 gram
1 milliliter of flavoring pineapple essence
Get Rhizoma Chuanxiong, Radix Angelicae Sinensis adds 10 times of amounts of water, soaks 1 hour, reflux, extract, 30 minutes is collected volatilization profit and aqueous solution, the Aromatic water of collection device is in addition preserved, cold preservation is placed standby; Medicinal residues and remaining Radix Astragali, the Radix Polygoni Multiflori, Rhizoma Zingiberis Preparatum three flavors add 8 times of water gagings of water, decoct twice, each decocting time 1 hour, and collecting decoction filters, and medicinal residues are abandoned; The relative density that filtrate is concentrated into 70-80 ℃ of heat survey is 1.21-1.25, filterable while hot extractum, and device is preserved standby in addition;
Get brown sugar, add 50% water boil after the chopping, filter, filtrate adds 0.3% citric acid, keeps 102-105 ℃ of temperature, and is 2 hours time, standby;
Get white sugar, added 50% water boil 30 minutes, add 0.1% tartaric acid, stir evenly, keep little 105 ℃ of temperature of boiling, 2 hours time, standby;
With above-mentioned clear paste, refining brown sugar and refining white sugar mixing, boil, to relative density 1.070 when above, placement, be chilled to below 60 ℃, add the Aromatic water of the above-mentioned preparation of using the tween 80 solubilising and the flavoring pineapple essence of total amount 0.1%, stir evenly, make 1000 milliliters, fill, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97100156A CN1053381C (en) | 1997-01-13 | 1997-01-13 | Drug for promoting puerperal physiological recovery and curing postpartum disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97100156A CN1053381C (en) | 1997-01-13 | 1997-01-13 | Drug for promoting puerperal physiological recovery and curing postpartum disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1187993A CN1187993A (en) | 1998-07-22 |
| CN1053381C true CN1053381C (en) | 2000-06-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97100156A Expired - Lifetime CN1053381C (en) | 1997-01-13 | 1997-01-13 | Drug for promoting puerperal physiological recovery and curing postpartum disease |
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|---|---|
| CN (1) | CN1053381C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104826079A (en) * | 2015-05-30 | 2015-08-12 | 路云香 | Traditional Chinese medicine for treating parturient paresis |
| CN112656892B (en) * | 2020-12-16 | 2022-01-28 | 冷嫦娥 | Medicated diet soup recipe for conditioning postpartum confinement and conditioning method |
-
1997
- 1997-01-13 CN CN97100156A patent/CN1053381C/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 基层中医临床必读大系(中药分册)第一版 1995.3.1 周安方，中国科学技术出版社 * |
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| Publication number | Publication date |
|---|---|
| CN1187993A (en) | 1998-07-22 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: TAIJI GROUP SICHUAN TAIJI PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: SINO-AMERICA JOINT VENTURE SICHUAN TAIJI PHARMACEUTICAL CO., LTD. |
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| CP03 | Change of name, title or address |
Address after: 610021 Southwest Airlines Economic Development Zone, Chengdu, Sichuan, Shuangliu County Patentee after: Sichuan Taiji Pharmaceutical Co., Ltd. of Taiji Group Address before: 610021, No. 27, south section of Ring Road, Sichuan, Chengdu Patentee before: Sino-America Joint Venture Sichuan Taiji Pharmaceutical Co., Ltd. |
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| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 19980722 Assignee: CHONGQING TONGJUNGE PHARMACEUTICAL FACTORY CO., LTD. OF TAIJI GROUP Assignor: Sichuan Taiji Pharmaceutical Co., Ltd. of Taiji Group Contract record no.: 2014500000002 Denomination of invention: Drug for promoting puerperal physiological recovery and curing postpartum disease Granted publication date: 20000614 License type: Exclusive License Record date: 20140126 |
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| CX01 | Expiry of patent term |
Granted publication date: 20000614 |
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| EXPY | Termination of patent right or utility model |