CN118286383A - 一种治疗儿童咳嗽的药物组合物及其制剂和应用 - Google Patents
一种治疗儿童咳嗽的药物组合物及其制剂和应用 Download PDFInfo
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Abstract
本发明公开了一种治疗儿童咳嗽的药物组合物及其应用,所述药物组合物包括如下重量份的组分:黄芪1‑20份、甘草2‑30份、桂枝1‑20份、淮牛膝1‑20份、益智仁1‑20份、莱菔子1‑20份、黄柏1‑20份、桃仁0.5‑10份、蛇床子1‑20份、台乌1‑20份、牡蛎2‑30份、炮姜0.3‑9份、赤小豆2‑30份、炒枳实1‑20份、白芥子2‑30份、丹皮1‑20份、桔梗1‑20份,所述药物组合物可添加药学上可接受的辅料,制成制剂。所述药物组合物及制剂可用于治疗咳嗽。
Description
技术领域
本发明属于中药领域,具体涉及一种治疗儿童咳嗽的药物组合物及其制剂和应用。
背景技术
儿童咳嗽是呼吸***较为常见的疾病之一,全年均可发病,以冬春季节较为常见,研究显示超过75%的患儿每年因咳嗽就诊次数超过5次,14%的患儿就诊次数甚至超过15次。儿童咳嗽的病因与成人不尽相同,可供选用的药物和干预措施又有限。中医认为小儿行气未充,五脏娇嫩,肌肤柔弱,抵御外部邪气侵袭的能力较弱;小儿脾常不足,容易乳食、生冷食物所伤,喜食肥腻、厌食蔬菜导致饮食内伤。无论是外感还是内伤均会肺气不宣、津液失布、肺失宣肃而引起咳嗽。经研究咳嗽的病因不再局限于外感、内伤两类。现认为咳嗽是由多种因素共同作用所致的一类疾病: 禀赋异常,环境刺激,鼻、咽喉、胃等相关因素均可导致咳嗽的发生。风邪伏肺、邪壅肺窍、胃气上逆及诸脏先伤后传于肺所致的肺失宣降、肺气上逆均可作咳。儿童咳嗽分类:1.按咳嗽病程分:按照咳嗽持续时间,儿童咳嗽分为急性咳嗽(<2周)、迁延性咳嗽(2~4周)和慢性咳嗽(>4周)。2.按咳嗽性质分类:根据无痰或有痰,将咳嗽分为干性咳嗽和湿性咳嗽。肺脾气虚证咳嗽:症见咳嗽无力,痰稀色白,久延难愈,神疲自汗,气短懒言,面白少华,少食纳呆,反复感冒,舌质淡,苔薄白,脉细无力或指纹淡。西医主要通过注射、口服及雾化吸入抗生素、激素、止咳化痰药来缓解咳嗽症状,如长大量使用可给儿童胃肠功能、肝肾功能、血液***造成严重损害,还可产生耐药性及菌群失调等副作用。
发明内容
针对现有技术存在的不足,本发明的目的在于提供一种治疗儿童咳嗽的药物组合物及其制剂和应用。本发明所述的药物组合物可用于儿童咳嗽,尤其针对肺脾气虚所致的儿童咳嗽有很好的治疗效果。
本发明的目的是通过以下技术方案实现的:一种治疗咳嗽的药物组合物包括如下重量份的组分:黄芪1-20份、甘草2-30份、桂枝1-20份、淮牛膝1-20份、益智仁1-20份、莱菔子1-20份、黄柏1-20份、桃仁0.5-10份、蛇床子1-20份、台乌1-20份、牡蛎2-30份、炮姜0.3-9份、赤小豆2-30份、炒枳实1-20份、白芥子2-30份、丹皮1-20份、桔梗1-20份。
优选地,包括如下重量份的组分:黄芪3-8份、甘草7-15份、桂枝3-8份、淮牛膝3-8份、益智仁3-8份、莱菔子3-8份、黄柏3-8份、桃仁7-15份、蛇床子3-8份、台乌3-8份、牡蛎8-15份、炮姜1-3份、赤小豆8-15份、炒枳实3-8份、白芥子8-15份、丹皮3-8份、桔梗3-8份。
所述药物组合物,还包括焦山楂1-10份,神曲1-15份,豆蔻2-15份。
所述药物组合物,还包括炙紫菀1-10份,款冬花1-15份。
本发明的有益效果:
本发明以黄芪为君药,补气健脾、益气固表;通过补肺气,充气血而通经络,经络通而湿、痰、瘀得以消除。用桂枝、益智仁、莱菔子、桔梗共为臣药,温通经脉,助阳化气,温补脾阳从而降气化痰,宣肺祛痰、利咽排脓。以淮牛膝、黄柏、桃仁、蛇床子、台乌、牡蛎、炮姜、赤小豆、炒枳实、白芥子、丹皮、甘草为佐药,活血化瘀、清热燥湿、泻火解毒、软坚散结、破气消积、化痰除痞、温肺祛痰、祛痰止咳,协助君药和臣药更好地发挥疗效。
黄芪:甘,温。归肺、脾经,益气补中。用于气虚乏力,食少便溏。黄芪中主要成分为黄酮类、皂苷类、多糖类等,具有调节免疫,保护心血管与神经***等药理作用。
甘草:味甘,性平。归心、肺、脾经。补脾益气,清热解毒,祛痰止咳。用于心脾气虚、脾胃气虚、正气虚损者。甘草中主要成份为三萜皂苷类和黄酮类。具有镇咳、祛痰、抗炎、抗病毒等药理作用。
桂枝:味辛、甘,性温,归心、肺经。发汗解肌,温经通脉,助阳化气。用于风寒感冒、痰饮、水肿等。桂枝主要成份为桂皮醛,具有抗病原微生物,解热镇痛等药理作用。
淮牛膝:味苦、甘、酸、平。归肝、肾经。逐瘀通经,补肝肾。用于吐血、衄血。主要成分有齐墩果酸、多糖等。具有保肝、护肝、强心、增强免疫力等作用。
益智仁:性辛、温。归脾、肾经。温脾止泻摄唾。用于脾寒泄泻,腹中冷痛,口多唾涎等。主要成分二苯庚体类、类倍半萜及挥发油类。具有较强的抗疲劳和抗高温等作用。
莱菔子:味辛、甘、性平。归脾、胃、肺经。消食除胀、降气化痰。用于饮食停滞、痰壅喘咳。主要成分莱菔子素、芥子碱、多种氨基酸、维生素等。具有祛痰、镇咳、平喘等作用。
黄柏:味苦、寒,归肾、膀胱经。清热燥湿,泻火解毒,除骨蒸。用于阴虚火旺,盗汗骨蒸。主要成分小檗碱、药根碱等生物碱具有金黄色葡萄球菌、大肠杆菌等均有一定抑制作用。桃仁:味苦、甘,平。归心、肝、大肠经。活血化瘀,润肠通便,止咳平喘。用于肠燥便秘,咳嗽气喘。主要成分脂质类、糖类、苦杏仁苷等,具有抗肺纤维化、镇咳平喘等作用。
蛇床子:辛、苦,温;有小毒。归肾经。燥湿祛风,杀虫止痒,温肾壮阳。用于阴痒带下,湿疹瘙痒,湿痹腰痛,肾虚阳痿,宫冷***。主要成分挥发油、香豆素等。具有较强的支气管扩张、祛痰和平喘作用。
广台乌:辛,温。归肺、脾、肾、膀胱经。行气止痛,温肾散寒。用于寒凝气滞,胸腹胀痛,气逆喘急。主要成分挥发油、黄铜类、生物碱等具有抗病毒、抑菌等。
牡蛎:咸,微寒。归肝、胆、肾经。重镇安神,潜阳补阴,软坚散结。用于瘵病痰核,癥痕痞块。主要成分多种氨基酸及微量元素。具有镇静、抗惊厥、增强免疫力等。
炮姜:辛,热。归脾、胃、肾经。温经止血,温中止痛。用于阳虚失血,吐衄崩漏,脾胃虚寒,腹痛吐泻。主要成分含挥发油。具有缩短出血和凝血时间等。
赤小豆:甘、酸,平。归心、小肠经。利水消肿,解毒排脓。用于水肿胀满,脚气浮肿,黄疸尿赤,风湿热痹,痈肿疮毒,肠痈腹痛。
炒枳实:苦、辛、酸,微寒。归脾、胃经。破气消积,化痰散痞。用于积滞内停, 痞满胀痛,泻痢后重,大便不通,痰滞气阻,胸痹,结胸,脏器 下垂。主要成分黄酮类、生物碱类、挥发油等。具有强心、抗菌、抗氧化等作用。
白芥子:辛,温。归肺经。温肺豁痰利气,散结通络止痛。用于寒痰咳嗽,胸胁胀痛,痰滞经络,关节麻木、疼痛,痰湿流注朋疽肿毒。主要成分芥子苷、芥子酶、芥子碱等。具有祛痰、抑菌、杀菌等作用。
丹皮:苦、辛,微寒。归心、肝、肾经。清热凉血,活血化瘀。用于热
入营血,温毒发斑,吐血衄血,夜热早凉,无汗骨蒸,经闭痛经,跌扑伤痛, 痈肿疮毒。主要成分丹皮酚、牡丹酚苷等。具有解热、镇静、抑制真菌等作用。
桔梗:苦、辛,平。归肺经。宣肺,利咽,祛痰,排脓。用于咳嗽痰多,胸闷不畅,咽痛音哑,肺痈吐脓。主要成分五环三萜多糖苷、三萜皂苷、多聚糖等。具有较强的祛痰作用及止咳效果。
具体实施方式
下面结合实施例对本发明作进一步说明,但本发明并不局限于实施例。
实施例1
一种药物组合物,包括如下组分:黄芪5g、甘草10g、桂枝5g、淮牛膝5g、益智仁5g、莱菔子5g、黄柏5g、桃仁3g、蛇床子5g、台乌5g、牡蛎10g、炮姜2g、赤小豆10g、炒枳实5g、白芥子10g、丹皮5g、桔梗5g。
实施例2
一种药物组合物,包括如下组分:黄芪20g、甘草5g、桂枝10g、淮牛膝10g、益智仁15g、莱菔子15g、黄柏10g、桃仁5g、蛇床子15g、台乌15g、牡蛎20g、炮姜20g、赤小豆20g、炒枳实15g、白芥子15g、丹皮10g、桔梗20g。
实施例3
一种药物组合物,包括如下组分:黄芪10g、甘草10g、桂枝15g、淮牛膝15g、益智仁10g、莱菔子10g、黄柏15g、桃仁3g、蛇床子15g、台乌15g、牡蛎30g、炮姜9g、赤小豆30g、炒枳实20g、白芥子20g、丹皮20g、桔梗20g。
实施例4
一种药物组合物,包括如下组分:黄芪12g、甘草3g、桂枝9g、淮牛膝9g、益智仁3g、莱菔子15g、黄柏6g、桃仁5g、蛇床子12g、台乌6g、牡蛎9g、炮姜1g、赤小豆2g、炒枳实15g、白芥子9g、丹皮15g、桔梗9g。
实施例5
一种药物组合物,包括如下组分:黄芪15g、甘草12g、桂枝10g、淮牛膝20g、益智仁15g、莱菔子12g、黄柏9g、桃仁2g、蛇床子15g、台乌15g、牡蛎25g、炮姜6g、赤小豆25g、炒枳实25g、白芥子12g、丹皮9g、桔梗15g。实施例6
一种药物组合物,包括如下组分:黄芪1g、甘草2g、桂枝1g、淮牛膝1g、益智仁1g、莱菔子1g、黄柏1g、桃仁0.5g、蛇床子1g、台乌1g、牡蛎2g、炮姜0.3g、赤小豆2g、炒枳实1g、白芥子2g、丹皮1g、桔梗1g。
实施例7
一种药物组合物,包括法半夏10g,橘红12g,茯苓15g,其余同实施例3。
实施例8
一种药物组合物,包括法半夏9g,橘红6g,茯苓20g,其余同实施例2。
实施例9
一种药物组合物,包括法半夏1g,橘红1g,茯苓2g,其余同实施例1。
实施例10
一种药物组合物,包括党参15g,白术6g,山药15g,其余同实施例3。
实施例11
一种药物组合物,包括党参10g,白术12g,山药12g,其余同实施例2。
实施例12
一种药物组合物,包括党参1g,白术1g,山药1g,其余同实施例1。
实施例13
一种药物组合物,包括焦山楂10g,神曲15g,豆蔻15g,其余同实施例3。
实施例14
一种药物组合物,包括焦山楂5g,神曲8g,豆蔻6g,其余同实施例1。
实施例15
一种药物组合物,包括焦山楂1g,神曲1g,豆蔻2g,其余同实施例6。
实施例16
一种药物组合物,包括炙紫菀6g,款冬花9g,其余同实施例1。
实施例17
一种药物组合物,包括炙紫菀10g,款冬花15g,其余同实施例2。
实施例18
一种药物组合物,包括炙紫菀1g,款冬花1g,其余同实施例6。
应用实施例——本发明所述药物组合物用于治疗儿童咳嗽。
一、研究方法
选取近五年内符合儿童咳嗽病纳入标准的患者,运用本发明所述药物组合物进行治疗,观察其临床疗效及不良反应。
二、研究对象
肺脾气虚证型咳嗽病患者。
三、诊断标准
参照《中国儿童咳嗽诊断与治疗临床实践指南》(2021版)。
四、西医诊断标准
①以咳嗽为主要临床表现。②伴或不伴发热、流涕、头痛、咽痛等,双肺或可闻及干或湿啰音。
③肺部X线、CT检查无肺结核、肺炎、肺癌等实质性病变。
五、中医证候诊断标准
肺脾气虚证的诊断标准:
咳嗽咯痰,气短而喘,神疲乏力,食欲不振,腹胀便溏,或有面浮肢肿,舌淡苔白滑,脉沉细。以上肺部及脾胃症状各见3症以上及相应脉舌,即可确诊肺脾气虚证。
六、纳入标准
1、符合西医咳嗽病诊断标准者;
2、符合中医咳嗽病脾肺气虚证诊断标准者;
3、年龄在1~14周岁,男女不限;
4、肺部X线、CT检查无肺结核、肺炎、肺癌等实质性病变。
七、排除标准
1、不符合中西医儿童咳嗽诊断标准者;
2、肺癌、肺门***结核、淋巴瘤、肺门转移性恶性肿瘤、其他肉芽肿病;
3、年龄在1岁以下,或14岁以上者;
4、合并有心血管、肝、肾和造血***等严重原发性疾病;
5、精神病患者;
6、对研究药物过敏者;
7、不符合纳入标准,未按规定用药,无法判断疗效或资料不全等影响疗效或安全性判断者。
八、服用方法
1、将药物组合物制作成药包,用1000毫升冷水浸泡30分钟,煎开15分钟可服,之后每次可加冷水或不加,再煎开5分钟,每包服1-2天,每天3次。10天为一个疗程,每次服量按岁数累加,即1岁10毫升,2岁20毫升,以此类推。
2、服药期间,禁服清热解毒类药物;禁食辛辣香燥、生冷苦寒及难消化的食物。
3、注意防寒保暖。
九、疗效判定标准
1、痊愈:临床肺脾气虚症状消失,咳嗽消失。
2、显效:临床肺脾气虚症状消除,咳嗽减少,干湿啰音消失。
3、有效:临床肺脾气虚症状减轻或消除,咳嗽消失。
4、无效:治疗结束之后,临床肺脾气虚症状无改善,咳嗽持续增多,干湿啰音增多。
十、临床疗效总结
本研究共观察有效病例100例。其中男性患者50例,女性患者50例;年龄1~6岁者47例,7~14岁者53例。
运用本申请所述的药物组合物治疗100例咳嗽病患者中,观察治疗一个疗程(10天),治愈40例(40%),显效10例(10%),有效45例(45%),无效5例(5%)。治疗(10天)结束后,100例患者治疗总有效率为95%,临床研究观察项目见统计表。
十一、不良反应
临床应用显示无毒副作用及不良反应。
十二、典型病例
1、患者张某,女,3岁,持续咳嗽5天来诊,患儿家属代述咳嗽痰多,痰白清稀,咳嗽无力伴发热,体温38℃、鼻塞、流黄涕、咽痛,神疲乏力,食欲不振,眠差,大便溏,小便正常,舌质淡苔白,脉细无力。患者坚持服用一个疗程,咳嗽症状明显好转,痰液明显减少,热退,睡眠可,二便正常。
2、患者王某,男,6岁,咳嗽咳痰5日来诊,咳嗽痰多,色白,面色无华,食少纳呆,反复感冒,体温正常,鼻塞无涕,大便质稀,舌质淡苔白腻,脉细沉。患者坚持治疗2个疗程,咳嗽咳痰症状消失,二便正常。
3、患者吴某,女,5岁,反复咳嗽半月余来诊,患儿母亲代述,近半月来反复咳嗽,痰多色白而稀,夜咳剧烈,咽干,咽痛,鼻塞流涕,舌白苔白腻,脉弦数。患者坚持服药2个疗程,咳嗽明显好转,咽干,咽痛症状消失。
4、患者保某,男,2岁,咳嗽5日来诊,患儿5天前因受凉后咳嗽加剧,喉中痰鸣,咽部不适,鼻塞无涕,大便溏,舌苔白腻,脉细,指纹淡。患者服用1个疗程后咽部不适、鼻塞等症状消失,咳嗽明显好转。
5、患者黄某,女,10岁,咳嗽痰多1周来诊,患者自述,咳嗽痰多,咳声无力,神疲乏力,面色白,呛咳明显,夜间咳盛,时有咽痛,鼻流清涕,大便稀,舌苔白腻,脉弦无力。患者坚持治疗2个疗程后咽痛症状消失,二便正常,咳嗽咳痰明显好转。以上病例仅为临床观察的部分病例,所使用的药物组合物也仅是部分药物组合物,在实际临床使用中,根据患者不同的临床症状,对药物组合物中具体药物的用量可在本发明范围内任意选择。
在临床中,可针对不同患者对处方进行调整及加减:
(1)若为痰湿证,可加入法半夏1-12g,橘红1-15g,茯苓2-20g,增强燥湿化痰,理气宽中之功效。
(2)若为伴有气短懒言者,可加入党参1-20份,白术1-15份,山药1-20份。增强健脾益肺,燥湿利水,生津止咳功效。
(3)若为食少纳呆者,可加入焦山楂1-10份,神曲1-15份,豆蔻2-15份。增强化湿行气,健脾和胃功效。
(4)若为咳重痰多者,可加入炙紫菀1-10份,款冬花1-15份。增强润肺下气,止咳化痰功效。
Claims (9)
1.一种治疗儿童咳嗽的药物组合物,其特征在于,按重量份数计,由如下组分组成:黄芪1-20份、甘草2-30份、桂枝1-20份、淮牛膝1-20份、益智仁1-20份、莱菔子1-20份、黄柏1-20份、桃仁0.5-10份、蛇床子1-20份、台乌1-20份、牡蛎2-30份、炮姜0.3-9份、赤小豆2-30份、炒枳实1-20份、白芥子2-30份、丹皮1-20份、桔梗1-20份。
2.一种治疗儿童咳嗽的药物组合物,其特征在于在权利要求1所述的药物组合物的基础上还加入法半夏1-12份,橘红1-15份,茯苓2-20份。
3.一种用于治疗儿童咳嗽的药物组合物,其特征在于在权利要求1所述的药物组合物的基础上还加入党参1-20份,白术1-15份,山药1-20份。
4.一种治疗儿童咳嗽的药物组合物,其特征在于在权利要求1所述的药物组合物的基础上还加入焦山楂1-10份,神曲1-15份,豆蔻2-15份。
5.一种治疗儿童咳嗽的药物组合物,其特征在于在权利要求1所述的药物组合物的基础上还加入炙紫菀1-10份,款冬花1-15份。
6.一种权利要求1所述的药物组合物的制剂,其特征在于,由所述药物组合物添加药学上可接受的辅料,制成制剂。
7.根据权利要求6所述的药物组合物的制剂,其特征在于,所述制剂形式为按照常规方法制备的散剂、颗粒、胶囊或丸剂。
8.一种权利要求1至5任意一项所述的药物组合物在制备治疗儿童咳嗽的药物中的应用。
9.一种权利要求6~7任意一项所述的药物组合物的制剂在制备治疗儿童咳嗽的药物中的应用。
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101347612A (zh) * | 2008-09-02 | 2009-01-21 | 陕西关爱制药有限公司 | 一种治疗感冒咳嗽及急慢性支气管炎的组合药物及其制备方法 |
CN102205042A (zh) * | 2011-05-03 | 2011-10-05 | 王爱芹 | 一种治疗咳嗽型小儿流行性感冒的中药制备方法 |
CN103341151A (zh) * | 2013-07-31 | 2013-10-09 | 李红霞 | 用于治疗慢性支气管炎的中药 |
CN104758890A (zh) * | 2015-03-26 | 2015-07-08 | 孙红梅 | 一种治疗咳嗽的中药组合物 |
CN107773751A (zh) * | 2017-12-11 | 2018-03-09 | 廖海湘 | 一种止咳中药 |
-
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- 2024-06-04 CN CN202410716464.6A patent/CN118286383A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101347612A (zh) * | 2008-09-02 | 2009-01-21 | 陕西关爱制药有限公司 | 一种治疗感冒咳嗽及急慢性支气管炎的组合药物及其制备方法 |
CN102205042A (zh) * | 2011-05-03 | 2011-10-05 | 王爱芹 | 一种治疗咳嗽型小儿流行性感冒的中药制备方法 |
CN103341151A (zh) * | 2013-07-31 | 2013-10-09 | 李红霞 | 用于治疗慢性支气管炎的中药 |
CN104758890A (zh) * | 2015-03-26 | 2015-07-08 | 孙红梅 | 一种治疗咳嗽的中药组合物 |
CN107773751A (zh) * | 2017-12-11 | 2018-03-09 | 廖海湘 | 一种止咳中药 |
Non-Patent Citations (1)
Title |
---|
温桂荣;: "苓桂术甘汤治疗杂病探微", 世界中西医结合杂志, vol. 03, no. 02, 28 February 2008 (2008-02-28), pages 108 - 110 * |
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