CN117942364A - 一种祛痛祛湿酊剂及制备方法 - Google Patents
一种祛痛祛湿酊剂及制备方法 Download PDFInfo
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Abstract
本发明提出了一种祛痛祛湿酊剂及制备方法,包括以下质量份的原料:独活15‑25份、威灵仙10‑20份、透骨草10‑20份、追风伞10‑20份、半枫荷8‑15份、鸡血藤8‑15份、青风藤8‑15份、续断8‑15份、牛膝7‑13份、冰片0.05‑0.3份、透皮剂0.5‑2份。所述制备过程包括:配料、浸泡、煎煮、浓缩、混合。本发明的优点在于用本酊剂药方用祛风祛湿、活血通络、消肿止痛之精选中草药密封浸泡而成,该酊剂具有超强的渗透力,能快速渗透到病者痛患处,具有祛风除湿、舒筋活血、通络祛痛、强筋壮骨、消肿止痛、修复受损组织与细胞的功能,从而达到真正意义上的康复。该中药组合物搭配合理,可用于各种风湿痹痛、跌打损伤、劳损引起的经络不通、颈肩腰腿痛等,均有较好的疗效。
Description
技术领域
本发明涉及外用祛痛酊剂领域,特别是指一种祛痛祛湿酊剂及制备方法。
背景技术
风湿病是一种慢性的、反复发作的疼痛性疾病,是风寒湿邪侵入人体所致,风寒湿邪侵入人体后,导致筋脉阻塞不通,“不通则痛”,发作时间可以是几天、几周或几个月。风湿病多发于中老年人,患者常有肌肉、肌腿及关节、骨膜等部位发生红肿疼痛肿痛,阴雨寒冷天气其疼痛感加剧,患者常会因病变部位的疼痛,造成关节强直,严重影响身体健康。目前治疗风湿病以解热镇痛类药物及水杨酸制剂为主,其虽能暂时缓解疼痛,但却有病痛反复发作的缺陷,易引起食欲不振、耳鸣、头昏等毒性现象。目前虽然也有一些抗风湿酊剂,但是其药效还有欠缺,治疗效果有待提高。
随着社会经济的发展,人类生活水平在不断提高,其工作节奏也在不断地加快,使得人们多数从事伏案工作,体育锻炼较少,很多年轻人都会遇到身体疼痛的折磨,久站久坐、低头、驼背等脊柱和肌肉的不良姿态随着时间增长,造成了肌肉的劳损,出现疼痛。再加之各种风湿类风湿、腰椎间盘突出、颈椎间盘突出、各种腱鞘炎、肌筋膜炎等症状,造成了现代社会疼痛患者日益增加,并呈年轻化趋势。再加上夏季在空调室内吹冷风时间长了以后,会出现筋骨疼痛、四肢麻木,中老年人会出现腰背沉重、行走不便、骨关节变形症等症状,一些按摩推拿及止疼药品只是起到缓解的作用,无法进行根治。
现在临床上使用治疗的手段繁多,针灸、针刀、艾灸、推拿按摩等手段,要么增加患就诊患者的痛苦,要么操作复杂。有患者实施手术治疗,手术费不仅昂贵、风险性大,同时给病人精神和肉体上都带来了巨大的伤害。要想随时随地简单快捷有效的应对疼痛突发,止痛酊剂是一种可靠的方法,然而市面上,止痛酊剂的产品较多,仔细分析这些产品,要么是单纯西药制剂,要么是单纯的中药制剂,效果差强人意。
发明内容
本发明提出一种祛痛祛湿酊剂及制备方法,得到的酊剂能够有效祛风除湿、舒筋活血、通络祛痛。
本发明的技术方案是这样实现的:一种祛痛祛湿酊剂,其特征在于,包括以下质量份的原料:独活15-25份、威灵仙10-20份、透骨草10-20份、追风伞10-20份、半枫荷8-15份、鸡血藤8-15份、青风藤8-15份、续断8-15份、牛膝7-13份、冰片0.05-0.3份、透皮剂0.5-2份;75%乙醇140-275份,蓖麻油280-516份。
一种祛痛祛湿酊剂,包括以下质量份的原料:独活18-23份、威灵仙12-18份、透骨草12-18份、追风伞12-18份、半枫荷10-13份、鸡血藤10-13份、青风藤10-13份、续断10-13份、牛膝8-12份、冰片0.08-0.2份、透皮剂0.8-1.5份;75%乙醇170-245份,蓖麻油345-461份。
一种祛痛祛湿酊剂,包括以下质量份的原料:独活20份、威灵仙15份、透骨草15份、追风伞15份、半枫荷12份、鸡血藤12份、青风藤12份、续断12份、牛膝10份、冰片0.1份、透皮剂0.9份;75%乙醇210份,蓖麻油410份。
一种祛痛祛湿酊剂及制备方法,所述制备过程包括:
步骤1、配料:按照配方的质量分数称重后清洗干净,将追风伞、半枫荷、透骨草三味药材分为组分A;将独活、威灵仙、鸡血藤、青风藤、牛膝、续断、冰片共七味药材为组分B;透皮剂为组分C,备好另放;
步骤2、浸泡:将组分A用75%乙醇密闭浸泡10-20天,过滤备用;将组分B的药材加蓖麻油浸泡10-20天;
步骤3、煎煮:将充分浸泡后的组分B药材和蓖麻油上火加水煎煮三次,过滤出三道药汁,将三次所得药汁混合,静置后再沉淀过滤;
步骤4、浓缩:过滤净的药汁倒入锅中,先用大火煎熬加速水分蒸发让药汁慢慢变得稠厚,再改用小火进一步浓缩并不断搅拌,直到药汁滴在纸上不散开,即可得到浓缩药液;
步骤5、混合:把组分A浸泡过滤出的液体,倒入浓缩药液中,并加入组分C的透皮剂,放在小火上慢慢熬炼并不断搅拌,即可得到酊剂。
作为优选,所述步骤1中浸泡前将组分A和组分B药材分组后清洗并打碎研磨,细度为30-50目。
作为优选,所述步骤2中的75%乙醇加入质量为组分A药材质量的3-6倍,密闭浸泡10-16天;将组分B的药材加蓖麻油浸润令其充分吸收膨胀,再加蓖麻油高出药面8-15厘米,密闭浸泡12-17天。
作为优选,所述步骤2中的75%乙醇加入质量为组分A药材质量的5倍,密闭浸泡14天;组分B药材浸泡容器为洁净砂锅,蓖麻油在砂锅内浸润膨胀后,再加蓖麻油高出药面10厘米,密闭浸泡15天。
作为优选,所述步骤3煎煮,把组分B浸泡后的药材上火煎煮,先用大火煮沸,再用小火煮1小时左右,转为微火以沸为度煮2-4小时,过滤出头道药汁;将药渣按照前述流程再煮两次,得到药汁,将三次所得药汁混合,静置后再沉淀过滤。
作为优选,所述步骤4中浓缩:将煎煮过滤净的药汁倒入锅中,进行浓缩,先用大火煎熬,加速水分蒸发,并随时撇去浮沫,让药汁慢慢变得稠厚;再改用小火进一步浓缩,并不断搅拌,直到药汁滴在纸上不散开来为度,即可得到浓缩药液。
作为优选,所述步骤5中混合:把组分A中追风伞、半枫荷、透骨草浸泡过滤出的液体,以及透皮剂,倒入浓缩药液中,放在小火上慢慢熬炼1-3小时,期间不断用铲搅拌,直至将药液滴入清水中凝结成珠而不散即可。
与现有技术相比,本发明的优点在于:本酊剂药方用祛风祛湿、活血通络、消肿止痛之精选中草药密封浸泡而成,该酊剂具有超强的渗透力,能快速渗透到病者痛患处,具有祛风除湿、舒筋活血、通络祛痛、强筋壮骨、消肿止痛、修复受损组织与细胞的功能,从而达到真正意义上的康复。该中药组合物搭配合理,可用于各种风湿痹痛、跌打损伤、劳损引起的经络不通、颈肩腰腿痛等,均有较好的疗效。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
成分介绍:以下内容摘自百度健康医典(国家药品监督管理局联合创建)及百度健康:
独活:祛风湿药;独活有抗炎、镇痛、镇静、抗心律失常、抑制血小板聚集、解痉、抗血栓、抗肿瘤及延缓衰老等多种药理作用。
威灵仙:祛风湿药,威灵仙有镇痛、抗利尿、抗疟、降血糖、降血压、利胆等多种药理作用。
透骨草:祛风湿药;透骨草主治风湿痹痛,筋骨挛缩,寒湿脚气,腰部扭伤,瘫痪,闭经,阴囊湿疹,疮疖肿毒。
追风伞:追风伞为报春花科珍珠菜属植物狭叶落地梅的全草或根,狭叶排草多年生草本,须根淡黄色;其味辛,性温,归肝、脾、大肠经,具有舒筋活络、治骨折、治小儿惊风等功效。
半枫荷:半枫荷具有舒筋活血、祛风除湿的功效,作用可用于治疗风湿性关节炎、腰肌劳损、半身不遂、扭伤、腰腿痛等,外用也可用于刀伤出血。
鸡血藤:活血化瘀药;鸡血藤有扩张血管、抗血小板聚集、降血脂、改善动脉粥样硬化、促进造血、镇痛、抗肿瘤、抗病毒等多种药理作用。
青风藤:青风藤为防己科植物青藤及毛青藤的干燥根茎,其性平味苦、辛,归肝、脾经,具有祛风湿、利小便的功效。
续断:补虚药;续断有抗维生素E缺乏症、排脓、止血、镇痛、促进组织再生、促进骨损伤愈合等多种药理作用。
牛膝:活血化瘀药;牛膝有抗凝血、改善血液循环、降血压、抗衰老、调节机体免疫功能、降血糖、抗炎、抗病毒、抗肿瘤、镇痛、兴奋子宫等多种药理作用。
冰片:冰片为龙脑香料植物龙脑香树的树脂中析出的天然结晶性化合物,人工合成的机制冰片,以及艾纳香蒸馏结晶的加工品;本品具有止痛防腐、开窍醒神、清热生肌等功效。
透皮剂:透皮剂的作用有治疗疼痛、替代激素治疗、控制高血压、辅助戒烟、治疗皮肤疾病等。
实施例1:一种祛痛祛湿酊剂,包括以下质量份的原料:独活20g、威灵仙15g、透骨草15g、追风伞15g、半枫荷12g、鸡血藤12g、青风藤12g、续断12g、牛膝10g、冰片0.1g、透皮剂0.9g;75%乙醇210g,蓖麻油410g。
实施例2:一种祛痛祛湿酊剂,包括以下质量份的原料:独活23g、威灵仙18g、透骨草20g、追风伞20g、半枫荷13g、鸡血藤13g、青风藤13g、续断13g、牛膝12g、冰片0.2g、透皮剂1.5g;另配75%乙醇265g,蓖麻油461g。
实施例3:一种祛痛祛湿酊剂,包括以下质量份的原料:独活25g、威灵仙20g、透骨草18g、追风伞15g、半枫荷15g、鸡血藤15g、青风藤15g、续断15g、牛膝13g、冰片0.3g、透皮剂2g;另配75%乙醇240g,蓖麻油516g。
实施例1-3的祛痛祛湿酊剂制备步骤:
步骤1、配料:按照配方的质量份称重后清洗干净,将透骨草、追风伞、半枫荷三味药材分为组分A;将独活、威灵仙、鸡血藤、青风藤、牛膝、续断、冰片共七味药材为组分B;透皮剂为组分C,备好另放;将组分A和组分B药材清洗并打碎研磨,细度为50目。
步骤2、浸泡:将组分A的追风伞、半枫荷、透骨草用75%乙醇密闭浸泡14天,过滤备用;将组分B的药材放洁净砂锅内,加适量的蓖麻油浸润药料,令其充分吸收膨胀,后再加蓖麻油以高出药面10厘米左右,密闭浸泡15天;
步骤3、煎煮:将充分浸泡后的组分B药材和蓖麻油上火加水煎煮三次,先用大火煮沸,再用小火煮1小时左右,转为微火以沸为度,约3小时左右,待药汁渐浓,即可用纱布过滤出头道药汁;再加清水浸润原药渣后再次上火煎煮,煎法同前,此为二煎,待至第三煎时,气味已淡薄,滤净药汁后即将药渣倒弃,将前三煎所得药汁混合一处,静置后再沉淀过滤,以药渣愈少愈佳;
步骤4、浓缩:过滤净的药汁倒入锅中,进行浓缩,先用大火煎熬,加速水分蒸发,并随时撇去浮沫,让药汁慢慢变得稠厚;再改用小火进一步浓缩,并不断搅拌,直到药汁滴在纸上不散开来为度,即可得到浓缩药液;
步骤5、混合:把组分A中追风伞、半枫荷、透骨草浸泡过滤出的液体,以及透皮剂,倒入浓缩药液中,放在小火上慢慢熬炼,不断用铲搅拌,直至将药液滴入清水中凝结成珠而不散即可。
实施例4:一种祛痛祛湿酊剂,包括以下质量份的原料:独活19g、威灵仙14g、透骨草14g、追风伞14g、半枫荷11g、鸡血藤11g、青风藤11g、续断11g、牛膝9g、冰片0.09g、透皮剂0.8g;另配75%乙醇195g,蓖麻油376g。
实施例5:一种祛痛祛湿酊剂,包括以下质量份的原料:独活15g、威灵仙10g、透骨草10g、追风伞10g、半枫荷9g、鸡血藤9g、青风藤9g、续断9g、牛膝7g、冰片0.05g、透皮剂0.7g;另配75%乙醇145g,蓖麻油280g。
实施例6:一种祛痛祛湿酊剂,包括以下质量份的原料:独活17g、威灵仙11g、透骨草11g、追风伞11g、半枫荷10g、鸡血藤10g、青风藤10g、续断10g、牛膝8g、冰片0.08g、透皮剂1.2g;另配75%乙醇160g,蓖麻油331g。
实施例4-6的祛痛祛湿酊剂制备步骤:
步骤1、配料:按照配方的质量份称重后清洗干净,将透骨草、追风伞、半枫荷三味药材分为组分A;将独活、威灵仙、鸡血藤、青风藤、牛膝、续断、冰片共七味药材为组分B;透皮剂为组分C,备好另放;将组分A和组分B药材清洗并打碎研磨,细度为30目。
步骤2、浸泡:将组分A的追风伞、半枫荷、透骨草用75%乙醇260g密闭浸泡12天,过滤备用;将组分B的药材放洁净砂锅内,加适量的蓖麻油浸润药料,令其充分吸收膨胀,后再加蓖麻油以高出药面10厘米,密闭浸泡12天;
步骤3、煎煮:将充分浸泡后的组分B药材和蓖麻油上火加水煎煮三次,先用大火煮沸,再用小火煮1小时左右,转为微火2小时左右,待药汁渐浓,即可用纱布过滤出头道药汁;再加清水浸润原药渣后再次上火煎煮,煎法同前,此为二煎,待至第三煎时,气味已淡薄,滤净药汁后即将药渣倒弃,将前三煎所得药汁混合一处,静置后再沉淀过滤,以药渣愈少愈佳;
步骤4、浓缩:过滤净的药汁倒入锅中,进行浓缩,先用大火煎熬,加速水分蒸发,并随时撇去浮沫,让药汁慢慢变得稠厚;再改用小火进一步浓缩,并不断搅拌,直到药汁滴在纸上不散开来为度,即可得到浓缩药液;
步骤5、混合:把组分A中追风伞、半枫荷、透骨草浸泡过滤出的液体,以及透皮剂,倒入浓缩药液中,放在小火上慢慢熬炼,不断用铲搅拌,直至将药液滴入清水中凝结成珠而不散即可。
表1:实施例1-实施例6各组分的质量配比
原料 | 实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 实施例6 |
独活 | 20g | 23g | 25g | 19g | 15g | 17g |
威灵仙 | 15g | 18g | 20g | 14g | 10g | 11g |
透骨草 | 15g | 20g | 18g | 14g | 10g | 11g |
追风伞 | 15g | 20g | 15g | 14g | 10g | 11g |
半枫荷 | 12g | 13g | 15g | 11g | 9g | 10g |
鸡血藤 | 12g | 13g | 15g | 11g | 9g | 10g |
青风藤 | 12g | 13g | 15g | 11g | 9g | 10g |
续断 | 12g | 13g | 15g | 11g | 9g | 10g |
牛膝 | 10g | 12g | 13g | 9g | 7g | 8g |
冰片 | 0.1g | 0.2g | 0.3g | 0.09g | 0.05g | 0.08g |
透皮剂 | 0.9g | 1.5g | 2g | 0.8g | 0.7g | 1.2g |
75%乙醇 | 210g | 265g | 240g | 195g | 145g | 160g |
蓖麻油 | 410g | 461g | 516g | 376g | 280g | 331g |
本酊剂具有祛风除湿、舒筋活血、通络祛痛的保健功效;对风湿痹痛、跌打损伤、劳损引起的经络不通、颈肩腰腿痛等均有较好的疗效。
用法用量:涂擦或喷涂患处,可按摩5-10分钟,按摩期间需要再喷擦几次,最后喷涂一次,用保鲜贴敷患处3-4小时则效果更佳,一日喷擦3-5次。或者将药喷擦在防渗棉上,贴敷在患处1-2天。
临床试验实验对象:经正规医院检查患有风湿性关节炎的患者500例,患者出现骨关节局部疼痛、红肿、发热和运动受限的症状。观察验证本发明酊剂(实施例1-6)和药店出售的治疗骨关节炎的外用药物(对比例1-4)对关节疼痛的治疗效果。
各种类型关节炎所致的关节疼痛及肿胀的患者500例,随机分为10组,每组各50例。各组年龄、性别、病程、病因、关节疼痛程度无统计学差异(p>0.05)。
治疗方法:
将药液均匀涂抹在关节处,一天3-5次,五天一个疗程。
判定标准:
1、痊愈:关节疼痛感消失或基本消失,关节活动恢复正常,无关节肿胀现象;
2、有效:关节疼痛感有所好转,关节活动轻度受限,可伴有轻度的关节肿胀现象;
3、无效:关节疼痛感无明显改善,甚或加重,关节活动受限,运作牵强。
表2:各试验组临床疗效统计表
总人数 | 痊愈 | 有效 | 无效 | 有效率 | |
实施例1 | 50 | 48 | 2 | 0 | 100% |
实施例2 | 50 | 45 | 4 | 1 | 98% |
实施例3 | 50 | 46 | 2 | 2 | 96% |
实施例4 | 50 | 43 | 4 | 3 | 94% |
实施例5 | 50 | 40 | 6 | 4 | 92% |
实施例6 | 50 | 42 | 5 | 3 | 94% |
对比药物1 | 50 | 39 | 5 | 6 | 88% |
对比药物2 | 50 | 33 | 7 | 10 | 80% |
对比药物3 | 50 | 28 | 12 | 10 | 80% |
对比药物4 | 50 | 36 | 6 | 8 | 84% |
从表2中可以看出,经过30天短暂的治疗,使用本发明药酊1-6实施例的患者基本痊愈,尤其是实施例1配比效果最明显,说明本发明治疗风湿骨病的药酊中的部分成分是需要经过严格流程炮制处理后效果才会更好。而使用药店出售的治疗骨关节炎的药物对比例1-4的在30天内的治疗效果相对比较明显不佳。
案例列举:
病例1:张某,男,45岁,患有手指痛,遇到湿冷天气就疼痛难忍,伴有膝关节红肿、麻木。用实施例1的酊剂2个月后,疼痛感消失,在湿冷天气手指和膝关节也无红肿、麻木、疼痛症状坚持使用本酊剂6个月后,完全康复,未发现有毒副作用。
病例2:林某,男,60岁,患者四肢怕冷怕风,手腕及指关节、膝关节、趾关节肿胀疼痛,触按痛甚,阴雨天或入夜痛剧已一年,常以西药布络芬等药控制疼痛。用实施例1的酊剂半个月后,疼痛感明显减缓,3个月后患者关节疼痛消失,功能活动正常,类风湿病未复发,康复痊愈并从事正常的体力劳动。
病例3:杨某,男,31岁,右踝关节肿胀疼痛1天就诊,因踢足球时不慎至右踝关节肿胀,右踝关节红肿,压痛,踝关节各方向受限,活动受限,核磁未见明显骨折,提示韧带损伤及局部水肿,诊断为踝关节软组织损伤,门诊予以实施例3酊剂贴敷治疗,患者当日治疗结束后,疼痛减轻,活动范围变大,疗程4天后,症状明显改善,行走尚可,10天后基本痊愈。
病例4:李某,女长期伏案工作,腰椎劳损严重,且伴有肩周炎和颈椎增生,尝试过多种方法治疗,比如吃消炎镇痛药物、按摩、针灸等均效果不佳,平时无法弯腰、睡觉时腰部酸胀,无法入睡,已经影响到正常生活工作,使用实施例4酊剂外敷3日后,腰椎疼痛明显改善,继续使用1个月后,疼痛症状彻底消失,可以正常工作和生活。
病例5:罗某,女,51岁,患有腰椎盘突出5年,经常性出现腰椎疼痛,不能久坐、久站、疼痛时只能靠吃止痛药强行阵痛;去医院治疗后效果不佳,疼痛经常反复发作,后又去做理疗,亦没有显著缓解的效果。使用本方案实施例5酊剂外敷3日后,腰椎疼痛明显改善,继续使用1个月后,疼痛症状彻底消失,后断断续续使用,未复发。
病例6:孙某,男,35岁,背部疼痛,痛呈刺痛,活动后加重,经休息可缓解,双肩胛骨内侧压痛明显,无放射痛,其他查体无特殊。初步诊断:腰背部肌筋膜炎。处理:实施例6的酊剂外敷,每日三次,变化:3日后复诊:患者自述疼痛症状明显缓解。嘱继续外敷此酊剂,每天三次。7日后复诊:腰背部疼痛症状完全消失。总结:腰背部肌筋膜炎引起的局部疼痛使用该酊剂可以明显缓解。
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.一种祛痛祛湿酊剂,其特征在于,包括以下质量份的原料:独活15-25份、威灵仙10-20份、透骨草10-20份、追风伞10-20份、半枫荷8-15份、鸡血藤8-15份、青风藤8-15份、续断8-15份、牛膝7-13份、冰片0.05-0.3份、透皮剂0.5-2份;75%乙醇140-275份,蓖麻油280-516份。
2.根据权利要求1所述的一种祛痛祛湿酊剂,其特征在于,包括以下质量份的原料:独活18-23份、威灵仙12-18份、透骨草12-18份、追风伞12-18份、半枫荷10-13份、鸡血藤10-13份、青风藤10-13份、续断10-13份、牛膝8-12份、冰片0.08-0.2份、透皮剂0.8-1.5份;75%乙醇170-245份,蓖麻油345-461份。
3.根据权利要求1所述的一种祛痛祛湿酊剂,其特征在于,包括以下质量份的原料:独活20份、威灵仙15份、透骨草15份、追风伞15份、半枫荷12份、鸡血藤12份、青风藤12份、续断12份、牛膝10份、冰片0.1份、透皮剂0.9份;75%乙醇210份,蓖麻油410份。
4.根据权利要求1-3任一项所述的一种祛痛祛湿酊剂的制备方法,其特征在于,所述制备过程包括:
步骤1、配料:按照配方的质量份称重后清洗干净,将透骨草、追风伞、半枫荷三味药材分为组分A;将独活、威灵仙、鸡血藤、青风藤、牛膝、续断、冰片共七味药材为组分B;透皮剂为组分C,备好另放;
步骤2、浸泡:将组分A用75%乙醇密闭浸泡10-20天,过滤备用;将组分B的药材放入蓖麻油中浸泡10-20天;
步骤3、煎煮:将充分浸泡后的组分B药材和蓖麻油上火加水煎煮三次,过滤出三道药汁,将三次所得药汁混合,静置后再沉淀过滤;
步骤4、浓缩:过滤净的药汁倒入锅中,先用大火煎熬加速水分蒸发让药汁慢慢变得稠厚,再改用小火进一步浓缩并不断搅拌,直到药汁滴在纸上不散开,即可得到浓缩药液;
步骤5、混合:把组分A浸泡过滤出的液体,倒入浓缩药液中,并加入组分C的透皮剂,放在小火上慢慢熬炼并不断搅拌,即可得到酊剂。
5.根据权利要求4所述的一种祛痛祛湿酊剂及制备方法,其特征在于:所述步骤1中浸泡前将组分A和组分B药材分组后清洗并打碎研磨,细度为30-50目。
6.根据权利要求4所述的一种祛痛祛湿酊剂及制备方法,其特征在于:所述步骤2中的75%乙醇加入质量为组分A药材质量的3-6倍,密闭浸泡10-16天;将组分B的药材加蓖麻油浸润令其充分吸收膨胀,再加蓖麻油高出药面8-15厘米,密闭浸泡12-17天。
7.根据权利要求6所述的一种祛痛祛湿酊剂及制备方法,其特征在于:所述步骤2中的75%乙醇加入质量为组分A药材质量的5倍,密闭浸泡14天;组分B药材浸泡容器为洁净砂锅,蓖麻油在砂锅内浸润膨胀后,再加蓖麻油高出药面10厘米,密闭浸泡15天。
8.根据权利要求4所述的一种祛痛祛湿酊剂及制备方法,其特征在于:所述步骤3煎煮,把组分B浸泡后的药材上火煎煮,先用大火煮沸,再用小火煮1小时左右,转为微火以沸为度煮2-4小时,过滤出头道药汁;将药渣按照前述流程再煮两次,得到药汁,将三次所得药汁混合,静置后再沉淀过滤。
9.根据权利要求4所述的一种祛痛祛湿酊剂及制备方法,其特征在于:所述步骤4中浓缩:将煎煮过滤净的药汁倒入锅中,进行浓缩,先用大火煎熬,加速水分蒸发,并随时撇去浮沫,让药汁慢慢变得稠厚;再改用小火进一步浓缩,并不断搅拌,直到药汁滴在纸上不散开来为度,即可得到浓缩药液。
10.根据权利要求4所述的一种祛痛祛湿酊剂及制备方法,其特征在于:所述步骤5中混合:把组分A中追风伞、半枫荷、透骨草浸泡过滤出的液体,以及透皮剂,倒入浓缩药液中,放在小火上慢慢熬炼1-3小时,期间不断用铲搅拌,直至将药液滴入清水中凝结成珠而不散即可。
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