CN117860631A - Skin care composition with effect of effectively repairing skin barrier, and preparation process and application thereof - Google Patents
Skin care composition with effect of effectively repairing skin barrier, and preparation process and application thereof Download PDFInfo
- Publication number
- CN117860631A CN117860631A CN202410042942.XA CN202410042942A CN117860631A CN 117860631 A CN117860631 A CN 117860631A CN 202410042942 A CN202410042942 A CN 202410042942A CN 117860631 A CN117860631 A CN 117860631A
- Authority
- CN
- China
- Prior art keywords
- parts
- skin
- polysaccharide
- care composition
- skin care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 28
- 230000000694 effects Effects 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 44
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 38
- 239000005017 polysaccharide Substances 0.000 claims abstract description 38
- 150000004676 glycans Chemical class 0.000 claims abstract description 24
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 22
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 22
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims abstract description 22
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 22
- 229940036350 bisabolol Drugs 0.000 claims abstract description 22
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 22
- 238000000855 fermentation Methods 0.000 claims abstract description 22
- 230000004151 fermentation Effects 0.000 claims abstract description 22
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 22
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 22
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 22
- 229940032094 squalane Drugs 0.000 claims abstract description 22
- YPUZOECTETYPRF-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrimidine-2-carboxylic acid Chemical compound OC(=O)C1NCC=CN1 YPUZOECTETYPRF-UHFFFAOYSA-N 0.000 claims abstract description 21
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 21
- -1 polysaccharide compound polysaccharide Chemical class 0.000 claims abstract description 13
- 229940059958 centella asiatica extract Drugs 0.000 claims abstract description 12
- 239000006166 lysate Substances 0.000 claims abstract description 12
- 229940064064 purslane extract Drugs 0.000 claims abstract description 12
- 244000025272 Persea americana Species 0.000 claims abstract description 8
- 235000008673 Persea americana Nutrition 0.000 claims abstract description 8
- 239000011347 resin Substances 0.000 claims abstract description 8
- 229920005989 resin Polymers 0.000 claims abstract description 8
- 244000014047 Polianthes tuberosa Species 0.000 claims abstract description 7
- 235000016067 Polianthes tuberosa Nutrition 0.000 claims abstract description 7
- 108090000637 alpha-Amylases Proteins 0.000 claims abstract description 7
- 241000187693 Rhodococcus rhodochrous Species 0.000 claims abstract description 6
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 20
- 239000011259 mixed solution Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 14
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 14
- 239000008213 purified water Substances 0.000 claims description 14
- 229940057910 shea butter Drugs 0.000 claims description 14
- 238000005303 weighing Methods 0.000 claims description 11
- 239000013592 cell lysate Substances 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N Tetrahydropalmatine Natural products C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 13
- 208000027418 Wounds and injury Diseases 0.000 abstract description 13
- 230000008439 repair process Effects 0.000 abstract description 9
- 230000035876 healing Effects 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 201000004624 Dermatitis Diseases 0.000 abstract description 2
- 235000016709 nutrition Nutrition 0.000 abstract description 2
- 230000035764 nutrition Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 19
- 238000012360 testing method Methods 0.000 description 10
- 238000009472 formulation Methods 0.000 description 6
- 230000029663 wound healing Effects 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 241001104043 Syringa Species 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/34—Oils, fats, waxes or natural resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a skin care composition with an effect of effectively repairing skin barrier, a preparation process and application thereof. The skin care composition comprises the following raw materials in parts by weight: 1.4-1.6 parts of avocado resin, 0.2-0.4 part of ceramide NP, 1.2-1.8 parts of hyaluronic acid, 0.4-0.6 part of bisabolol, 0.5-1.0 part of centella asiatica extract, 1-1.5 parts of cholesterol, 0.8-1.2 parts of purslane extract, 0.1-0.3 part of squalane, 0.8-1.2 parts of oligopeptide-1, 0.4-0.6 part of tetrahydropyrimidine carboxylic acid and 1-2 parts of a lysate of a fermentation product of two-split yeasts. The composition can provide moisture and nutrition for damaged skin of skin barrier, is beneficial to relieving skin inflammation, promoting skin to be relaxed and recovered, effectively repairing the skin barrier and promoting skin smoothness and elasticity. Based on the composition, the pullulanase polysaccharide, the rhodococcus rhodochrous polysaccharide and the tuberose polysaccharide compound polysaccharide are added, and the prepared dressing has higher healing rate on wounds, can repair skin barriers more effectively and rapidly, and has stronger skin barrier repair effect.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a skin care composition with an effect of effectively repairing skin barriers, and a preparation process and application thereof.
Background
The skin barrier is the first line of defense of the skin and plays an important role in preventing water loss, protecting against external stimuli, and maintaining skin health. Damaged skin barriers are prone to skin sensitivity and inflammatory reactions. Damaged skin barriers are also prone to various skin problems such as dryness, allergies, acne, etc. Damaged skin barriers can lead to skin loss of smoothness and elasticity, which is prone to dryness, roughness and sagging. The skin-repairing skin-protecting product can provide moisturizing, nourishing and other functions, and is helpful for repairing damaged skin barrier function. Therefore, development of skin barrier repair products is of great importance.
Disclosure of Invention
In view of the above, the invention provides a skin care composition with an effect of effectively repairing skin barrier, and a preparation process and application thereof.
The technical scheme of the invention is realized as follows:
a skin care composition effective in repairing skin barrier effects comprising the following raw materials in parts by weight: 1.4-1.6 parts of avocado resin, 0.2-0.4 part of ceramide NP, 1.2-1.8 parts of hyaluronic acid, 0.4-0.6 part of bisabolol, 0.5-1.0 part of centella asiatica extract, 1-1.5 parts of cholesterol, 0.8-1.2 parts of purslane extract, 0.1-0.3 part of squalane, 0.8-1.2 parts of oligopeptide-1, 0.4-0.6 part of tetrahydropyrimidine carboxylic acid and 1-2 parts of a lysate of a fermentation product of two-split yeasts.
Preferably, the skin care composition comprises the following raw materials in parts by weight: 1.5 parts of avocado resin, 0.3 part of ceramide NP, 1.5 parts of hyaluronic acid, 0.5 part of bisabolol, 0.8 part of centella asiatica extract, 1.2 parts of cholesterol, 1 part of purslane extract, 0.2 part of squalane, 1 part of oligopeptide-1, 0.5 part of tetrahydropyrimidine carboxylic acid and 1.5 parts of a lysate of a fermentation product of the saccharomyces cerevisiae.
Further, the skin care composition further comprises a compound polysaccharide, wherein the compound polysaccharide is composed of at least two of pullulanase polysaccharide, rhodococcus rhodochrous polysaccharide and tuberose polysaccharide.
Further, the mass ratio of pullulanase polysaccharide, rhodococcus rhodochrous polysaccharide and tuberose polysaccharide in the compound polysaccharide is 1:1.8-2.2:1.2-1.5.
Further, the skin care composition comprises the following raw materials in parts by weight: 1.4-1.6 parts of avocado resin, 0.2-0.4 part of ceramide NP, 1.2-1.8 parts of hyaluronic acid, 0.4-0.6 part of bisabolol, 0.5-1.0 part of centella asiatica extract, 1-1.5 parts of cholesterol, 0.8-1.2 parts of purslane extract, 0.1-0.3 part of squalane, 0.8-1.2 parts of oligopeptide-1, 0.4-0.6 part of tetrahydropyrimidine carboxylic acid, 1-2 parts of a lysate of a fermentation product of a saccharomyces cerevisiae and 0.8-1.2 parts of compound polysaccharide.
Preferably, the skin care composition is prepared from the following raw materials in parts by weight: 1.4 to 1.6 percent of avocado resin, 0.2 to 0.4 percent of ceramide NP, 1.2 to 1.8 percent of hyaluronic acid, 0.4 to 0.6 percent of bisabolol, 0.5 to 1.0 percent of centella asiatica extract, 1 to 1.5 percent of cholesterol, 0.8 to 1.2 percent of purslane extract, 0.1 to 0.3 percent of squalane, 0.8 to 1.2 percent of oligopeptide-1, 0.4 to 0.6 percent of tetrahydropyrimidine carboxylic acid, 1 to 2 percent of lysate of fermentation products of the two-split yeast, 0.8 to 1.2 percent of compound polysaccharide and the balance purified water.
Preferably, the skin care composition is prepared from the following raw materials in parts by weight: 1.5% of shea butter, 0.3% of ceramide NP, 1.5% of hyaluronic acid, 0.5% of bisabolol, 0.8% of centella asiatica extract, 1.2% of cholesterol, 1% of purslane extract, 0.2% of squalane, 1% of oligopeptide-1, 0.5% of tetrahydropyrimidine carboxylic acid, 1.5% of lysate of fermentation products of saccharomyces cerevisiae, 1% of complex polysaccharide and 90% of purified water.
The preparation process of the skin care composition for effectively repairing skin barrier effect comprises the following steps:
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 5-10min at 50-60 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 3-8min to obtain mixed solution;
(2) Cooling the mixed solution to 38-42deg.C, adding herba Portulacae extract, herba Centellae extract, and cell lysate of fermentation product of Saccharomyces cerevisiae, and squalane, and vacuum homogenizing for 5-10 min.
Further, the preparation process of the skin care composition for effectively repairing skin barrier effect comprises the following steps:
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 5-10min at 50-60 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 3-8min to obtain mixed solution;
(2) Cooling the mixed solution to 38-42deg.C, adding herba Portulacae extract, herba Centellae extract, cell lysate of fermentation product of two-split yeast, squalane and compound polysaccharide, and vacuum homogenizing for 5-10 min.
Compared with the prior art, the invention has the beneficial effects that:
(1) The dressing prepared from the composition consisting of the shea butter, the ceramide NP, the hyaluronic acid, the bisabolol, the centella asiatica extract, the cholesterol, the purslane extract, the squalane, the oligopeptide-1, the tetrahydropyrimidine carboxylic acid and the lysate of the fermentation product of the two-split yeast has higher healing rate on wounds, can effectively and quickly repair skin barriers, and has stronger skin barrier repair effect.
(2) Based on the composition provided by the invention, pullulanase polysaccharide, rhodococcus rhodochrous polysaccharide and tuberose polysaccharide compound polysaccharide are added, and the prepared dressing has higher healing rate on wounds, can repair skin barriers more effectively and rapidly, and has stronger skin barrier repair effect.
(2) The composition provided by the invention provides moisture and nutrition for damaged skin of skin barrier, is beneficial to relieving skin inflammation, promoting skin to relax and recover, effectively repairing skin barrier and promoting skin smoothness and elasticity.
Detailed Description
In order to better understand the technical content of the present invention, the following provides specific examples to further illustrate the present invention.
The experimental methods used in the embodiment of the invention are conventional methods unless otherwise specified.
Materials, reagents, and the like used in the examples of the present invention are commercially available unless otherwise specified.
The raw materials used in the invention are all commercial cosmetic raw materials.
Example 1
1 formulation table
2 production process
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 8min at 55+/-5 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 5min to obtain mixed solution;
(2) Cooling the mixed liquid to 40+ -2deg.C, adding herba Portulacae extract, herba Centellae extract, and cell lysate of yeast fermentation product, and squalane, and vacuum homogenizing for 8min to obtain dressing.
Example 2
1 formulation table
2 production process
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 8min at 55+/-5 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 5min to obtain mixed solution;
(2) Cooling the mixed liquid to 40+ -2deg.C, adding herba Portulacae extract, herba Centellae extract, and cell lysate of yeast fermentation product, and squalane, and vacuum homogenizing for 8min to obtain dressing.
Example 3
1 formulation table
2 production process
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 8min at 55+/-5 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 5min to obtain mixed solution;
(2) Cooling the mixed liquid to 40+ -2deg.C, adding herba Portulacae extract, herba Centellae extract, and cell lysate of yeast fermentation product, and squalane, and vacuum homogenizing for 8min to obtain dressing.
Example 4
1 formulation table
2 production process
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 8min at 55+/-5 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 5min to obtain mixed solution;
(2) Cooling the mixed solution to 40+ -2deg.C, adding herba Portulacae extract, herba Centellae extract, cell lysate of fermentation product of two-split yeast, squalane, and compound polysaccharide (composed of pullulanase polysaccharide, syringa purpurea polysaccharide and tuberose polysaccharide with mass ratio of 1:2:1.3), and vacuum homogenizing for 10min to obtain dressing.
Comparative example 1
1 formulation table
2 production process
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 8min at 55+/-5 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 5min to obtain mixed solution;
(2) Cooling the mixed liquid to 40+ -2deg.C, adding herba Portulacae extract, herba Centellae extract, and cell lysate of yeast fermentation product, and squalane, and vacuum homogenizing for 8min to obtain dressing.
Comparative example 2
The main difference from example 4 is that no complex polysaccharide is added, but trehalose is added.
1 formulation table
2 production process
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 8min at 55+/-5 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 5min to obtain mixed solution;
(2) Cooling the mixed liquid to 40+ -2deg.C, adding herba Portulacae extract, herba Centellae extract, cell lysate of fermentation product of two-split yeast, squalane and trehalose, and vacuum homogenizing for 10min to obtain dressing.
Test examples
Test example 1-biocompatibility
The dressings prepared in examples 1 to 4 and comparative examples 1 to 2 were subjected to animal skin irritation test, in vitro cytotoxicity test, skin sensitization test, respectively, and the results showed no irritation, no toxicity, and no sensitization.
Test example 2 wound healing test
Healthy rats are selected, weighing 300-320 g, randomly grouped, and 10 animals in each group, male and female halves. Blank groups and test groups 1 to 6, respectively, and test groups 1 to 6 correspond to examples 1 to 4 and comparative examples 1 to 2 in order. The back hair on both sides of the back of the rat was shaved off the day before the test, and the hair removal area was about 2cm by 2cm. The rats were anesthetized by injection of anesthetic, and then the skin areas were cleaned with disinfectant and the skin areas were wound 1.5cm by 1.5cm using a sterilizing bladeThe epidermis of the rat was lacerated without damaging the dermis, and a 1.5cm damaged wound was formed. The wound was cleaned with 0.9% NaCl, and then dressing was applied to the wound in an amount of 1.0 g.kg -1 ·d -1 The administration was continued for 7 days. The blank group did not use dressing. Photographing a rat wound, and observing the healing condition of the wound: whether bleeding, penetrating fluid, suppuration, crusting and the like exist or not, measuring the size of the wound healing by using a measuring scale, and calculating the wound healing rate.
Wound healing rate = (pre-use wound area-post-use wound area)/pre-use wound area 100%
TABLE 1 wound healing Condition
Compared with blank group, P is less than or equal to 0.01, P is less than 0.05
The results show that the wound healing rate of each test group is improved after 7 days of dressing application, and the difference has statistical significance compared with the blank group. Wounds using the dressing of examples 1-4 had a high healing rate and were able to repair skin barriers effectively and quickly, with the dressing of example 4 having the strongest skin barrier repair effect.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (10)
1. A skin care composition effective in repairing skin barrier effects, comprising the following ingredients in parts by weight: 1.4-1.6 parts of avocado resin, 0.2-0.4 part of ceramide NP, 1.2-1.8 parts of hyaluronic acid, 0.4-0.6 part of bisabolol, 0.5-1.0 part of centella asiatica extract, 1-1.5 parts of cholesterol, 0.8-1.2 parts of purslane extract, 0.1-0.3 part of squalane, 0.8-1.2 parts of oligopeptide-1, 0.4-0.6 part of tetrahydropyrimidine carboxylic acid and 1-2 parts of a lysate of a fermentation product of the saccharomyces cerevisiae.
2. The skin care composition according to claim 1, comprising the following raw materials in parts by weight: 1.5 parts of avocado resin, 0.3 part of ceramide NP, 1.5 parts of hyaluronic acid, 0.5 part of bisabolol, 0.8 part of centella asiatica extract, 1.2 parts of cholesterol, 1 part of purslane extract, 0.2 part of squalane, 1 part of oligopeptide-1, 0.5 part of tetrahydropyrimidine carboxylic acid and 1.5 parts of lysate of fermentation products of the two-split yeasts.
3. The skin care composition according to claim 1, further comprising a complex polysaccharide consisting of at least two of pullulanase polysaccharide, rhodococcus rhodochrous polysaccharide, tuberose polysaccharide.
4. A skin care composition according to claim 3, wherein the mass ratio of pullulanase polysaccharide, rhodococcus rhodochrous polysaccharide and tuberose polysaccharide in the complex polysaccharide is 1:1.8-2.2:1.2-1.5.
5. The skin care composition according to claim 3 or 4, characterized by comprising the following raw materials in parts by weight: 1.4-1.6 parts of avocado resin, 0.2-0.4 part of ceramide NP, 1.2-1.8 parts of hyaluronic acid, 0.4-0.6 part of bisabolol, 0.5-1.0 part of centella asiatica extract, 1-1.5 parts of cholesterol, 0.8-1.2 parts of purslane extract, 0.1-0.3 part of squalane, 0.8-1.2 parts of oligopeptide-1, 0.4-0.6 part of tetrahydropyrimidine carboxylic acid, 1-2 parts of a lysate of a fermentation product of a saccharomyces cerevisiae and 0.8-1.2 parts of compound polysaccharide.
6. The skin care composition according to claim 5, which is prepared from the following raw materials in parts by weight: 1.4 to 1.6 percent of shea butter, 0.2 to 0.4 percent of ceramide NP, 1.2 to 1.8 percent of hyaluronic acid, 0.4 to 0.6 percent of bisabolol, 0.5 to 1.0 percent of centella asiatica extract, 1 to 1.5 percent of cholesterol, 0.8 to 1.2 percent of purslane extract, 0.1 to 0.3 percent of squalane, 0.8 to 1.2 percent of oligopeptide-1, 0.4 to 0.6 percent of tetrahydropalmatine carboxylic acid, 1 to 2 percent of a lysate of a fermentation product of the schizosaccharomyces, 0.8 to 1.2 percent of compound polysaccharide and the balance of purified water.
7. The skin care composition according to claim 6, wherein the skin care composition is prepared from the following raw materials in parts by weight: 1.5% shea butter, 0.3% ceramide NP, 1.5% hyaluronic acid, 0.5% bisabolol, 0.8% centella asiatica extract, 1.2% cholesterol, 1% purslane extract, 0.2% squalane, 1% oligopeptide-1, 0.5% tetrahydropyrimidine carboxylic acid, 1.5% split yeast fermentation product lysate, complex polysaccharide 1.0%, purified water 90%.
8. A process for preparing a skin care composition according to any one of claims 1 to 2, comprising the steps of:
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 5-10min at 50-60 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 3-8min to obtain mixed solution;
(2) Cooling the mixed solution to 38-42deg.C, adding herba Portulacae extract, herba Centellae extract, and cell lysate of fermentation product of Saccharomyces cerevisiae, and squalane, and vacuum homogenizing for 5-10 min.
9. A process for preparing a skin care composition according to any one of claims 3 to 6, comprising the steps of:
(1) Respectively weighing raw materials, adding shea butter, ceramide NP, hyaluronic acid and tetrahydropyrimidine carboxylic acid into purified water, and stirring for 5-10min at 50-60 ℃; adding bisabolol, cholesterol and oligopeptide-1, and stirring for 3-8min to obtain mixed solution;
(2) Cooling the mixed solution to 38-42deg.C, adding herba Portulacae extract, herba Centellae extract, cell lysate of fermentation product of two-split yeast, squalane and compound polysaccharide, and vacuum homogenizing for 5-10 min.
10. Use of a skin care composition according to any one of claims 1 to 7 or a skin care composition obtainable by the process according to claim 8 or 9 for the preparation of a dressing for repairing a skin barrier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410042942.XA CN117860631A (en) | 2024-01-11 | 2024-01-11 | Skin care composition with effect of effectively repairing skin barrier, and preparation process and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410042942.XA CN117860631A (en) | 2024-01-11 | 2024-01-11 | Skin care composition with effect of effectively repairing skin barrier, and preparation process and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117860631A true CN117860631A (en) | 2024-04-12 |
Family
ID=90576959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410042942.XA Pending CN117860631A (en) | 2024-01-11 | 2024-01-11 | Skin care composition with effect of effectively repairing skin barrier, and preparation process and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117860631A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498431A (en) * | 2018-06-27 | 2018-09-07 | 广州澳希亚实业有限公司 | Cosmetic composition containing algae and cosmetic composition |
| CN110403831A (en) * | 2019-07-26 | 2019-11-05 | 李和伟 | A kind of functionality antiallergic barrier ink-jet ink and its preparation method and application |
| CN111202799A (en) * | 2020-02-14 | 2020-05-29 | 张秀燕 | Wound nursing spray |
| CN111329803A (en) * | 2020-03-05 | 2020-06-26 | 上海尔岚生物科技有限公司 | Whitening essence and preparation method thereof |
| CN111973501A (en) * | 2019-12-05 | 2020-11-24 | 上海遇鑫生物科技有限公司 | Ceramide activation milk and preparation method thereof |
| CN115282105A (en) * | 2022-08-12 | 2022-11-04 | 陈伟 | Infant Tong Hufu composition and preparation method thereof |
| CN117243844A (en) * | 2023-11-16 | 2023-12-19 | 成都普什制药有限公司 | Collagen-containing skin care product essence and preparation method and application thereof |
-
2024
- 2024-01-11 CN CN202410042942.XA patent/CN117860631A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498431A (en) * | 2018-06-27 | 2018-09-07 | 广州澳希亚实业有限公司 | Cosmetic composition containing algae and cosmetic composition |
| CN110403831A (en) * | 2019-07-26 | 2019-11-05 | 李和伟 | A kind of functionality antiallergic barrier ink-jet ink and its preparation method and application |
| CN111973501A (en) * | 2019-12-05 | 2020-11-24 | 上海遇鑫生物科技有限公司 | Ceramide activation milk and preparation method thereof |
| CN111202799A (en) * | 2020-02-14 | 2020-05-29 | 张秀燕 | Wound nursing spray |
| CN111329803A (en) * | 2020-03-05 | 2020-06-26 | 上海尔岚生物科技有限公司 | Whitening essence and preparation method thereof |
| CN115282105A (en) * | 2022-08-12 | 2022-11-04 | 陈伟 | Infant Tong Hufu composition and preparation method thereof |
| CN117243844A (en) * | 2023-11-16 | 2023-12-19 | 成都普什制药有限公司 | Collagen-containing skin care product essence and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王建新: "《化妆品植物原料大全"》", 30 June 2012, 中国纺织出版社, pages: 377 - 378 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109044915B (en) | Infant hip-protecting cream and preparation process thereof | |
| CN111632075B (en) | Exosome preparation for promoting skin wound healing and preparation method thereof | |
| CN111249187A (en) | Wrinkle-removing eye cream and preparation method thereof | |
| CN109172388A (en) | Ceramide III containing liposome has anti-aging, the facial mask liquid of sebum barrier reparation and preparation method thereof | |
| CN114712275A (en) | Anti-wrinkle repair composition and preparation method thereof, and cosmetic and preparation method thereof | |
| CN110917055A (en) | Oligopeptide repair essence and preparation process thereof | |
| CN113413356A (en) | Peach tocol-based acne-removing composition and preparation method thereof | |
| CN108261361A (en) | A kind of anti-acne repairing paste containing Porcine HGF and preparation method thereof | |
| CN112107724A (en) | Liquid dressing and preparation method thereof | |
| CN113908097A (en) | Acne-removing composition and application thereof | |
| CN109875944A (en) | A kind of facial mask liquid and preparation method thereof | |
| CN112022795A (en) | Skin care and repair composition, preparation method and application thereof | |
| CN112315840A (en) | Mussel mucin scalp repair composition, repair liquid and preparation method thereof | |
| CN117860631A (en) | Skin care composition with effect of effectively repairing skin barrier, and preparation process and application thereof | |
| CN110946802A (en) | Camellia flower sleeping mask capable of relieving and moisturizing and preparation method of camellia flower sleeping mask | |
| CN114053175B (en) | Acne-removing product and preparation method thereof | |
| CN108853369B (en) | Preparation method and application of natural plant antibacterial liquid PAMs hydrogel patch | |
| CN110664668A (en) | Acne-removing skin-care gel containing water-soluble cannabidiol and preparation method thereof | |
| CN112168759A (en) | Infant skin lotion and preparation method thereof | |
| CN112353740A (en) | Nail-protecting composition, nail-protecting hand cream and preparation method thereof | |
| CN112494346A (en) | Emulsion with anti-aging function and preparation method thereof | |
| CN112022768A (en) | Liquid cosmetic formula and preparation method thereof | |
| CN116459171B (en) | Composition with allergy-relieving and repairing effects, essence and preparation method thereof | |
| CN114533809B (en) | Vitamin E antibacterial cream and preparation method thereof | |
| CN116327630B (en) | Preparation and application of giant salamander peptide composite liquid crystal emulsion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |