CN117814268A - Compound quaternary ammonium salt sterilizing disinfectant and preparation method thereof - Google Patents
Compound quaternary ammonium salt sterilizing disinfectant and preparation method thereof Download PDFInfo
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- CN117814268A CN117814268A CN202311840265.8A CN202311840265A CN117814268A CN 117814268 A CN117814268 A CN 117814268A CN 202311840265 A CN202311840265 A CN 202311840265A CN 117814268 A CN117814268 A CN 117814268A
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- quaternary ammonium
- ammonium salt
- extract
- disinfectant
- plant
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 80
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 67
- -1 Compound quaternary ammonium salt Chemical class 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title abstract description 17
- 239000000419 plant extract Substances 0.000 claims abstract description 75
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 75
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000002131 composite material Substances 0.000 claims abstract description 35
- 239000003094 microcapsule Substances 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 23
- 150000001412 amines Chemical class 0.000 claims abstract description 19
- 239000000126 substance Substances 0.000 claims abstract description 16
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 15
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 15
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 15
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims description 43
- 238000002156 mixing Methods 0.000 claims description 24
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims description 20
- 240000003553 Leptospermum scoparium Species 0.000 claims description 20
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 20
- 240000007651 Rubus glaucus Species 0.000 claims description 20
- 235000011034 Rubus glaucus Nutrition 0.000 claims description 20
- 235000009122 Rubus idaeus Nutrition 0.000 claims description 20
- 239000002994 raw material Substances 0.000 claims description 20
- 241000196324 Embryophyta Species 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 13
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 11
- 229960001950 benzethonium chloride Drugs 0.000 claims description 11
- QYCBIOKOKSULOM-UHFFFAOYSA-N decyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCC[NH2+]C QYCBIOKOKSULOM-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 5
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- 235000005979 Citrus limon Nutrition 0.000 claims description 3
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- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 3
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 claims description 3
- IKVDMBQGHZVMRN-UHFFFAOYSA-N n-methyldecan-1-amine Chemical compound CCCCCCCCCCNC IKVDMBQGHZVMRN-UHFFFAOYSA-N 0.000 claims description 3
- JMHWNJGXUIJPKG-UHFFFAOYSA-N CC(=O)O[SiH](CC=C)OC(C)=O Chemical compound CC(=O)O[SiH](CC=C)OC(C)=O JMHWNJGXUIJPKG-UHFFFAOYSA-N 0.000 claims description 2
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 claims description 2
- SQWXJWJNQGQPPN-UHFFFAOYSA-M [Cl-].O(C1=CC=CC=C1)CCOCC[N+](C)(C)C Chemical compound [Cl-].O(C1=CC=CC=C1)CCOCC[N+](C)(C)C SQWXJWJNQGQPPN-UHFFFAOYSA-M 0.000 claims description 2
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 2
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims description 2
- OCBHHZMJRVXXQK-UHFFFAOYSA-M benzyl-dimethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 OCBHHZMJRVXXQK-UHFFFAOYSA-M 0.000 claims description 2
- WLCFKPHMRNPAFZ-UHFFFAOYSA-M didodecyl(dimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCC WLCFKPHMRNPAFZ-UHFFFAOYSA-M 0.000 claims description 2
- RSHHCURRBLAGFA-UHFFFAOYSA-M dimethyl-di(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCC RSHHCURRBLAGFA-UHFFFAOYSA-M 0.000 claims description 2
- REZZEXDLIUJMMS-UHFFFAOYSA-M dimethyldioctadecylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC REZZEXDLIUJMMS-UHFFFAOYSA-M 0.000 claims description 2
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 claims description 2
- XEUYTSFFGRRIIU-UHFFFAOYSA-N n-methyldecan-1-amine;hydrobromide Chemical compound Br.CCCCCCCCCCNC XEUYTSFFGRRIIU-UHFFFAOYSA-N 0.000 claims description 2
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- 239000000022 bacteriostatic agent Substances 0.000 claims 3
- MLFIYYDKLNZLAO-UHFFFAOYSA-N 2-aminoethane-1,1-diol Chemical compound NCC(O)O MLFIYYDKLNZLAO-UHFFFAOYSA-N 0.000 claims 1
- 230000001877 deodorizing effect Effects 0.000 abstract description 24
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 20
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 11
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- 125000001453 quaternary ammonium group Chemical class 0.000 description 9
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- NYNKJVPRTLBJNQ-UHFFFAOYSA-N n'-(3-aminopropyl)-n'-dodecylpropane-1,3-diamine Chemical group CCCCCCCCCCCCN(CCCN)CCCN NYNKJVPRTLBJNQ-UHFFFAOYSA-N 0.000 description 7
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 229910021529 ammonia Inorganic materials 0.000 description 5
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- 229940005550 sodium alginate Drugs 0.000 description 5
- BHNHHSOHWZKFOX-UHFFFAOYSA-N 2-methyl-1H-indole Chemical compound C1=CC=C2NC(C)=CC2=C1 BHNHHSOHWZKFOX-UHFFFAOYSA-N 0.000 description 4
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- 108010010803 Gelatin Proteins 0.000 description 3
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
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- CEJLBZWIKQJOAT-UHFFFAOYSA-N dichloroisocyanuric acid Chemical compound ClN1C(=O)NC(=O)N(Cl)C1=O CEJLBZWIKQJOAT-UHFFFAOYSA-N 0.000 description 1
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- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of medical disinfectants, in particular to a compound quaternary ammonium salt sterilizing disinfectant and a preparation method thereof. The compound quaternary ammonium salt sterilizing disinfectant comprises compound quaternary ammonium salt, amine substances, nonionic surfactant, plant source bacteriostat, hydroxyethyl cellulose, absolute ethyl alcohol and water. The invention also provides a preparation method of the composite. Compared with the prior art, the compound quaternary ammonium salt sterilizing disinfectant prepared by the invention simultaneously introduces amine substances, double-chain quaternary ammonium salt, single-chain quaternary ammonium salt, plant extracts and plant extract microcapsule substances to perform synergistic interaction, further strengthen the sterilizing effect and have wider sterilizing range; the plant extract microcapsule is introduced to prolong the antibacterial, sterilizing and deodorizing performances, has a mild formula, does not irritate human bodies, is harmless to the human bodies, is healthy and environment-friendly, and is environment-friendly.
Description
Technical Field
The invention relates to the technical field of medical disinfectants, in particular to a compound quaternary ammonium salt sterilizing disinfectant and a preparation method thereof.
Background
Disinfectants are methods that reduce the risk of cross-contamination of surfaces by process disinfection. The disinfectants commonly used in the market at present are inorganic chlorines such as sodium hypochlorite, bleaching powder, bleaching essence, dichloro isocyanuric acid, trichloroisocyanuric acid and the like; alcohols such as 75% alcohol, isopropyl alcohol, complex alcohol, etc.; strong oxidants such as hydrogen peroxide and the like. Although these disinfectants have a very good disinfecting effect, they are very short-lived, have a poor long-lasting antimicrobial property and have a strong pungent smell.
The quaternary ammonium salt compound disinfectant can adsorb bacteria with negative charges, has good bactericidal effect and is widely used internationally.
CN116114715a discloses a low-temperature quaternary ammonium salt disinfectant for animals and a preparation method thereof, wherein the low-temperature quaternary ammonium salt disinfectant comprises quaternary ammonium salt disinfectant, mugwort leaf, wild chrysanthemum, garlic, bupleurum, deodorant, antifreeze, 70% ethanol and water, and the components are mixed according to the weight proportion: the quaternary ammonium salt disinfectant is 30-50 parts, the mugwort leaf is 5-10 parts, the wild chrysanthemum is 3-5 parts, the garlic is 6-15 parts, the bupleurum is 4-9 parts, the deodorant is 5-12 parts, the antifreeze is 2-5 parts, the 70% ethanol is 10-20 parts, and the balance is water, compared with the common disinfectant, the low-temperature quaternary ammonium salt disinfectant can not freeze, solidify and lose efficacy in the environment below zero, always keeps liquid state, can spray for disinfection, effectively kills escherichia coli, staphylococcus aureus and the like, the disinfection rate can also reach 99.99%, the safety of the disinfectant is improved by adopting a plurality of Chinese patent medicine methods, no peculiar smell is avoided, physical and mental health of animals is prevented from being damaged, and the disinfection effect is good;
therefore, a composite quaternary ammonium salt sterilizing disinfectant which is efficient, widely sterilized, strong in durability, safe, nontoxic or low in toxicity and free of irritation is urgently needed.
Disclosure of Invention
In order to achieve the above purpose, the invention provides a composite quaternary ammonium salt sterilizing disinfectant, which is characterized in that: the composite quaternary ammonium salt, amine substances, nonionic surfactant, hydroxyethyl cellulose, absolute ethyl alcohol and water.
Further preferably, the composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.2-2% of compound quaternary ammonium salt, 0.1-1% of amine substance, 0.1-5% of nonionic surfactant, 0.1-2% of hydroxyethyl cellulose, 12-16% of absolute ethyl alcohol and the balance of water.
The nonionic surfactant is one or a mixture of more of dodecyl dihydroxyethyl amine oxide and coco alkyl dihydroxyethyl amine oxide;
the amine substance is laurylamine dipropylene diamine.
The amine substances are mainly substances with positive charges formed in water and adsorbed on the surfaces of microorganisms with negative charges, so that micro-groups are formed to enter a lipoid layer of a cell membrane through osmosis, the permeability of the membrane is changed, the cell membrane is broken and the cell content is extravasated, and then the microorganisms are killed; meanwhile, the activity of various enzymes can be changed, the change of the expression quantity of related genes can be regulated, the metabolism of cells is hindered, and the bactericidal effect is good.
The compound quaternary ammonium salt is a mixture of double-chain quaternary ammonium salt and single-chain quaternary ammonium salt;
the double-chain quaternary ammonium salt is at least one of decylmethylammonium chloride, decylmethylammonium bromide, dioctyl dimethyl ammonium chloride, dioctadecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, ditetradecyl dimethyl ammonium chloride and 2- (2-phenoxyethoxy) ethyl trimethyl ammonium chloride.
The single-chain quaternary ammonium salt is at least one of benzalkonium bromide, benzalkonium chloride, benzethonium chloride, tetradecyldimethylbenzyl ammonium chloride, dodecyl dimethylbenzyl ammonium chloride, octadecyl trimethyl ammonium chloride and dodecyl trimethyl ammonium chloride.
Further, the compound quaternary ammonium salt is formed by mixing decylmethylamine chloride and benzethonium chloride according to the mass ratio of (1-3).
The double-chain quaternary ammonium salt compound is used as a common component of a disinfectant, and can change the permeability of a bacterial spore membrane to enable the outer permeation of components in bacteria to obstruct the metabolism of cells so as to enable the bacteria to die; the composite quaternary ammonium salt provided by the invention consists of single-chain quaternary ammonium salt and double-chain quaternary ammonium salt, and the disinfection and sterilization performances of the composite quaternary ammonium salt are superior to those of the single-chain quaternary ammonium salt and the double-chain quaternary ammonium salt; the double-chain quaternary ammonium salt contains two long-chain hydrophobic groups and two positively charged N in the structure + Through the induction, the positive charge density of quaternary nitrogen is increased, and the adsorption capacity of the disinfectant on the surface of bacteria is increased, so that the permeability of the film is changed, and the thalli are broken, so that the sterilization spectrum of the disinfectant can be effectively enlarged, and the sterilization effect can be enhanced; the nonionic surfactant molecules are inserted between the polar head groups of the ionic surfactant by means of hydrophobic interaction and interaction between the polar head groups, so that the charge density is improved, the bactericidal effect of the quaternary ammonium salt is enhanced, and the effect is improved.
However, when a certain disinfectant is used alone for a long time for surface disinfection, the surface disinfection can also generate antibiosis resistance; in order to further improve the antibacterial effect, a plant antibacterial and bactericidal preparation is introduced, and the combination of quaternary ammonium salt and natural biological antibacterial agent is adopted to improve the environmental problem, improve the antibacterial and disinfectant problems and improve the antibacterial resistance problem.
Further preferably, the composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.2-2% of compound quaternary ammonium salt, 0.1-1% of amine substance, 0.1-5% of nonionic surfactant, 0.1-10% of plant source bacteriostat, 0.1-2% of hydroxyethyl cellulose, 12-16% of absolute ethyl alcohol and the balance of water.
The plant source bacteriostat can be a plant extract;
furthermore, the plant-derived bacteriostat can also be a plant extract microcapsule;
further preferably, the plant-derived bacteriostat is a mixture of plant extracts and plant extract microcapsules; the plant source bacteriostat is formed by mixing plant extracts and plant extract microcapsules according to the mass ratio of 1 (1-3);
the plant extract is at least one of tea tree extract, sweet orange peel extract, peppermint extract, clove extract, lemon extract and raspberry extract;
raspberry (Rubus chingii Hu) is woody plant of Rubus genus of Rosaceae family, and has been described in Shennong Baicaojing earlier than Qin Han period, and Rubi fructus extract mainly comprises raspberry ketone, flavone, phenolic acid compounds, and has antioxidant, antibacterial and antiinflammatory effects; the raspberry ketone has characteristic fragrance of raspberry, has the effects of enhancing aroma and sweetness, endows fruits with fragrance and sweet fragrance, can keep fragrance lasting, and effectively weakens and inhibits the emission of malodorous substances.
The sweet orange peel extract contains a large amount of sweet orange oil, has tranquilization effect, has sweet orange flavor, can be used as spice, can purify and improve air, can remove tension and stress, and can improve insomnia caused by anxiety. The effective molecules in the raspberry extract, the sweet orange peel extract, the mint extract, the clove extract, the lemon extract and the tea tree extract mostly contain active groups, can act with peculiar smell molecules, and can achieve good deodorizing and sterilizing performances through the synergistic effect of various raw materials. The plant extract has deodorizing effect on the environment in the sterilization process, has strong adsorption effect, can be combined with harmful gases such as ammonia, hydrogen sulfide, methylindole and the like, reduces the concentration of the harmful gases, further improves the peculiar smell, and plays a certain role in deodorizing, sterilizing and disinfecting.
The plant extract contains a large amount of active ingredients with antibacterial, deodorizing and deodorizing properties, but the active substances are easy to oxidize and volatilize, and cannot exert the effects for a long time, so that the performance is required to be further improved.
The preparation method of the plant extract microcapsule comprises the following steps:
(1) Adding 1-3.5 parts by weight of hydroxyapatite into 20-30 parts by weight of water, and performing ultrasonic treatment for 1-2 hours to obtain a hydroxyapatite dispersion liquid, wherein the ultrasonic frequency is 15-25kHz, and the ultrasonic power is 100-500W; adding 7-8 parts by weight of sodium hydroxide and 10-15 parts by weight of urea into 90-100 parts by weight of water, uniformly mixing, then placing in a freezer for precooling for 10-30min at-15 to-10 ℃, adding 5-6 parts by weight of microcrystalline cellulose, stirring for 10-30min at 100-500r/min, placing in 0 ℃, finally adding 3-5 parts by weight of epichlorohydrin, stirring for 30-60min at 100-500r/min, drying for 12-24h at 50-60 ℃ to obtain gel, washing with water to neutrality, then placing in a freezer for freezing for 12-24h at-60 to-50 ℃, and finally freeze-drying to obtain aerogel;
(2) Pulverizing the obtained aerogel to 1-5 μm, adding the aerogel powder and plant extract into 60-80deg.C ethanol water solution, mixing for 10-30min, filtering, and drying to obtain aerogel loaded with plant extract, wherein the mass ratio of aerogel powder, plant extract, and ethanol water solution is (1-2): 1 (5-15);
(3) Adding 1-3 parts by weight of stabilizer, 2-4 parts by weight of gelatin and 5-15 parts by weight of aerogel loaded with plant extracts into 50-100 parts by weight of water, uniformly mixing, and then adding 100-200 parts by weight of 1-3wt% sodium alginate aqueous solution, uniformly stirring to obtain a mixed dispersion system; uniformly mixing 1-3wt% of chitosan quaternary ammonium salt aqueous solution and 1-2wt% of calcium chloride aqueous solution according to the mass ratio of (1-2): 1 to obtain chitosan quaternary ammonium salt-calcium chloride mixed solution; uniformly mixing the mixed dispersion system and the chitosan quaternary ammonium salt-calcium chloride mixed solution, wherein the volume ratio of the mixed dispersion system to the chitosan quaternary ammonium salt-calcium chloride mixed solution is 1:1, so as to obtain a mixed solution; adding 1-3 times volume of water into the mixed solution, stirring for 20-30min at 100-500r/min, standing at room temperature for 1-3 hr, filtering, and drying to obtain plant extract microcapsule.
The microcrystalline cellulose and the hydroxyapatite adopted by the invention have the characteristics of low cost, excellent biocompatibility, environmental friendliness, degradation and the like, the invention prepares the aerogel with the honeycomb structure by taking the hydroxyapatite and the microcrystalline cellulose as raw materials, and the hydroxyapatite is uniformly distributed in the microcrystalline cellulose, so that the aperture and the specific surface area of the aerogel are effectively improved, and the adsorption performance of the hydroxyapatite on plant extracts is improved; however, the aerogel loaded with the plant extract has poor compatibility in disinfectant, is easy to precipitate, and the plant extract is easy to desorb and disperse in the disinfectant, so that the slow release, long-term antibacterial, deodorizing and disinfecting performances of the aerogel are affected; the aerogel loaded with the plant extract is further taken as a matrix, and is wrapped by sodium alginate, chitosan quaternary ammonium salt and calcium chloride, so that the slow release performance is improved, and the effects of resisting bacteria, sterilizing and deodorizing are prolonged; the plant extract microgel prepared by the invention can well interact with active ingredients in the disinfectant, and the wall material of the microgel is slowly decomposed in the disinfectant, so that the microgel has long-term stability, and meanwhile, the disinfectant has lasting antibacterial, disinfecting, deodorizing and other effects; the plant-source bacteriostat adopted by the invention is synergistic by the plant extract and the plant extract microcapsule, and the plant extract microcapsule can solve the problem of performance disappearance or performance reduction after the volatilization of the plant extract. In the disinfection process, active substances of plant extracts in the disinfectant are easy to oxidize and volatilize, the plant extracts cannot play a role for a long time, and the plant extracts subjected to the slow-release treatment of the plant extract microcapsules can compensate the loss of the plant extracts and continuously play the roles of resisting bacteria and deodorizing.
The invention also provides a preparation method of the compound quaternary ammonium salt sterilizing disinfectant.
A preparation method of the compound quaternary ammonium salt sterilizing disinfectant comprises the following steps: according to the formula, the compound quaternary ammonium salt, the amine substances, the nonionic surfactant, the plant source bacteriostat, the hydroxyethyl cellulose, the absolute ethyl alcohol and the water are stirred and mixed uniformly to obtain the compound quaternary ammonium salt sterilizing disinfectant.
The composite quaternary ammonium salt sterilizing disinfectant provided by the invention has the advantages of convenient use, no toxicity, no stimulation, no corrosion and the like,
open-ended terms such as "comprising," including, "and the like as used herein also encompass the situation of" consisting of … ….
When the quaternary ammonium salt sterilizing disinfectant is used, the attention is also required to be paid:
(1) The external disinfectant should not be taken orally. Is placed at a place which is not easily touched by children.
(2) Avoiding mixing with anionic surfactant and soap.
(3) Light-proof, sealing, dampproof, and storing in shade and dry place.
The invention has the beneficial effects that:
1. compared with the prior art, the compound quaternary ammonium salt sterilizing disinfectant prepared by the invention simultaneously introduces amine substances, double-chain quaternary ammonium salt, single-chain quaternary ammonium salt, plant extracts and plant extract microcapsule substances to perform synergistic interaction, further strengthen the sterilizing effect and have wider sterilizing range; the plant extract microcapsule introduces the functions of prolonging the antibacterial, sterilizing and deodorizing.
2. Compared with the prior art, the raspberry extract and the tea tree extract are introduced, most of effective molecules in the raspberry extract and the tea tree extract contain active groups, can act with peculiar smell molecules, and can achieve good deodorizing and sterilizing performances through synergistic effect of various raw materials. The plant extract has deodorizing effect on the environment in the sterilization process, has strong adsorption effect, can be combined with harmful gases such as ammonia, hydrogen sulfide, methylindole and the like, reduces the concentration of the harmful gases, further improves the peculiar smell, and plays a certain role in deodorizing, sterilizing and disinfecting. The raspberry extract, the tea tree extract and the plant extract microcapsule are mixed to perform synergistic action, and the plant extract microcapsule can solve the problem of performance disappearance or performance reduction of the plant extract after volatilization.
3. The disinfectant prepared by the invention has the advantages of mild formula, no stimulation to human body, no harm to human body, health and environmental protection, and is environment-friendly.
Detailed Description
The endpoints of the ranges and any values disclosed in the present invention are not limited to the precise range or value, and the range or value should be understood to include values close to the range or value. For numerical ranges, one or more new numerical ranges may be obtained in combination with each other between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point values, and are to be considered as specifically disclosed in the present invention.
Some raw materials used in the embodiments of the present invention are described:
hydroxyapatite with a particle size of 100nm and a product number of 170508161249, (caramar) Shanghai spectral vibration biotechnology Co.
The preparation method of tea tree extract comprises cleaning tea leaves and branches, drying, pulverizing, reflux extracting with mixed solution of water and absolute ethanol at volume ratio of 5:95 twice, reflux extracting for 3 hr with 6 times of tea tree weight for the first time; adding 3 times of tea tree weight for the second time, and refluxing for 2 hours; mixing the two extractive solutions, and concentrating to obtain tea tree extract.
The preparation method of Rubi fructus extract comprises cleaning Rubi fructus, drying, pulverizing, reflux extracting with mixed solution of water and absolute ethanol at volume ratio of 10:90 twice, adding 5 times of Rubi fructus weight for the first time, and reflux extracting for 3 hr; adding 2 times of the weight of the raspberry for the second time, refluxing for 2 hours, combining the two extracting solutions, and concentrating to obtain the raspberry extract;
other raw materials not mentioned are common raw materials, the above is only to help illustrate the present invention, and should not be construed as a strict limitation of the present invention, and those skilled in the art can directly purchase or prepare the same/similar raw materials by themselves.
The following description of the embodiments of the present invention will clearly and fully describe the technical solutions of the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.5% of decylmethylamine chloride, 0.5% of benzethonium chloride, 0.6% of laurylamine dipropylene diamine, 1% of cocoalkyl bishydroxyethyl amine oxide, 4% of raspberry extract, 4% of tea tree extract, 1% of hydroxyethyl cellulose, 14% of absolute ethyl alcohol and the balance of water.
Example 2
The composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.5% of decylmethylamine chloride, 0.5% of benzalkonium chloride, 0.6% of laurylamine dipropylene diamine, 1% of cocoalkyl bishydroxyethyl amine oxide, 4% of raspberry extract, 4% of tea tree extract, 1% of hydroxyethyl cellulose, 14% of absolute ethyl alcohol and the balance of water.
Example 3
The composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.5% of decylmethylamine chloride, 0.5% of benzethonium chloride, 0.6% of laurylamine dipropylene diamine, 1% of cocoalkyl bishydroxyethyl amine oxide, 8% of plant extract microcapsules, 1% of hydroxyethyl cellulose, 14% of absolute ethyl alcohol and the balance of water;
the preparation method of the plant extract microcapsule comprises the following steps:
(1) Adding 3.1 parts by weight of hydroxyapatite into 25.4 parts by weight of water, and performing ultrasonic treatment for 2 hours to obtain a hydroxyapatite dispersion liquid, wherein the ultrasonic frequency is 20kHz, and the ultrasonic power is 200W; adding 7.5 parts by weight of sodium hydroxide and 12.2 parts by weight of urea into 92 parts by weight of water, uniformly mixing, then placing in a freezer for precooling for 20min at-13 ℃, adding 5.3 parts by weight of microcrystalline cellulose, stirring for 30min at 300r/min, placing at 0 ℃, finally adding 3.8 parts by weight of epichlorohydrin, stirring for 60min at 300r/min, drying at 55 ℃ for 12h to obtain gel, washing with water to be neutral, then placing at-54 ℃ for freezing for 12h, and finally freeze-drying to obtain aerogel;
(2) Pulverizing the obtained aerogel to 2 μm, adding the aerogel powder and the plant extract into 70wt% ethanol water solution, mixing for 30min, filtering, and drying to obtain aerogel loaded with the plant extract, wherein the mass ratio of the aerogel powder to the plant extract to the ethanol water solution is 1:1:10;
(3) Adding 2 parts by weight of paraffin, 3 parts by weight of gelatin and 10 parts by weight of aerogel loaded with plant extracts into 100 parts by weight of water, uniformly mixing, and then adding 200 parts by weight of 3wt% sodium alginate aqueous solution, uniformly stirring to obtain a mixed dispersion system; uniformly mixing 2.5 weight percent of chitosan quaternary ammonium salt aqueous solution and 2 weight percent of calcium chloride aqueous solution according to the mass ratio of 2:1 to obtain chitosan quaternary ammonium salt-calcium chloride mixed solution; uniformly mixing the mixed dispersion system and the chitosan quaternary ammonium salt-calcium chloride mixed solution, wherein the volume ratio of the mixed dispersion system to the chitosan quaternary ammonium salt-calcium chloride mixed solution is 1:1, so as to obtain a mixed solution; adding 3 times volume of water into the mixed solution, stirring for 20min at 300r/min, standing at room temperature for 3h, filtering, and drying to obtain plant extract microcapsule; wherein the plant extract is prepared by mixing raspberry extract and tea tree extract according to the mass ratio of 1:1.
Example 4
A composite quaternary ammonium salt disinfectant was substantially the same as in example 3, except that:
adopting aerogel loaded with plant extracts to replace plant extract microcapsules;
the preparation method of the plant extract-loaded aerogel comprises the following steps:
(1) Adding 3.1 parts by weight of hydroxyapatite into 25.4 parts by weight of water, and performing ultrasonic treatment for 2 hours to obtain a hydroxyapatite dispersion liquid, wherein the ultrasonic frequency is 20kHz, and the ultrasonic power is 200W; adding 7.5 parts by weight of sodium hydroxide and 12.2 parts by weight of urea into 92 parts by weight of water, uniformly mixing, then placing in a freezer for precooling for 20min at-13 ℃, adding 5.3 parts by weight of microcrystalline cellulose, stirring for 30min at 300r/min, placing at 0 ℃, finally adding 3.8 parts by weight of epichlorohydrin, stirring for 60min at 300r/min, drying at 55 ℃ for 12h to obtain gel, washing with water to be neutral, then placing at-54 ℃ for freezing for 12h, and finally freeze-drying to obtain aerogel;
(2) Pulverizing the obtained aerogel to 2 μm, adding the aerogel powder and the plant extract into 70wt% ethanol water solution, mixing for 30min, filtering, and drying to obtain the aerogel loaded with the plant extract, wherein the mass ratio of the aerogel powder to the plant extract to the ethanol water solution is 1:1:10.
Example 5
A composite quaternary ammonium salt disinfectant was substantially the same as in example 3, except that:
the preparation method of the plant extract microcapsule comprises the following steps:
adding 2 parts by weight of paraffin, 3 parts by weight of gelatin and 5 parts by weight of plant extract into 100 parts by weight of water, uniformly mixing, and then adding 200 parts by weight of 3wt% sodium alginate aqueous solution, uniformly stirring to obtain a mixed dispersion system; uniformly mixing 2.5 weight percent of chitosan quaternary ammonium salt aqueous solution and 2 weight percent of calcium chloride aqueous solution according to the mass ratio of 2:1 to obtain chitosan quaternary ammonium salt-calcium chloride mixed solution; uniformly mixing the mixed dispersion system and the chitosan quaternary ammonium salt-calcium chloride mixed solution, wherein the volume ratio of the mixed dispersion system to the chitosan quaternary ammonium salt-calcium chloride mixed solution is 1:1, so as to obtain a mixed solution; adding 3 times volume of water into the mixed solution, stirring for 20min at 300r/min, standing at room temperature for 3h, filtering, and drying to obtain plant extract microcapsule; wherein the plant extract is prepared by mixing raspberry extract and tea tree extract according to the mass ratio of 1:1.
Example 6
The composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.5% of decylmethylamine chloride, 0.5% of benzethonium chloride, 0.6% of laurylamine dipropylene diamine, 1% of cocoalkyl bishydroxyethyl amine oxide, 1% of raspberry extract, 1% of tea tree extract, 6% of plant extract microcapsules, 1% of hydroxyethyl cellulose, 14% of absolute ethyl alcohol and the balance of water; wherein the preparation method of the plant extract microcapsules is consistent with example 3.
Example 7
The composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.5% decylmethylamine chloride, 0.5% benzethonium chloride, 1% cocoalkyl bishydroxyethyl amine oxide, 4% raspberry extract, 4% tea tree extract, 1% hydroxyethyl cellulose, 14% absolute ethanol, and the balance water.
Comparative example 1
The composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.5% of decylmethylamine, 0.5% of benzethonium chloride, 0.6% of laurylamine dipropylene diamine, 1% of cocoalkyl bishydroxyethyl amine oxide, 8% of raspberry extract, 1% of hydroxyethyl cellulose, 14% of absolute ethyl alcohol and the balance of water.
Comparative example 2
The composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.5% of decylmethylamine, 0.5% of benzethonium chloride, 0.6% of laurylamine dipropylene diamine, 1% of cocoalkyl bishydroxyethyl amine oxide, 8% of tea tree extract, 1% of hydroxyethyl cellulose, 14% of absolute ethyl alcohol and the balance of water.
Comparative example 3
The composite quaternary ammonium salt sterilizing disinfectant comprises the following raw materials in percentage by mass: 0.5% decylmethylamine chloride, 0.5% benzethonium chloride, 1% cocoalkyl bishydroxyethyl amine oxide, 4% raspberry extract, 4% tea tree extract, 1% hydroxyethyl cellulose, the balance being water.
Test example 1
With reference to the "disinfection technical Specification" (2002 edition) 2.1.1, escherichia coli (Escherichia coli) 8099, staphylococcus aureus (Staphylococcus aureus) ATCC6538, candida albicans (Candida albicans) ATCC10231 and Pseudomonas aeruginosa (Pseudomonas aeruginosa) ATCC15442 were selected as tests, and antibacterial tests were conducted on disinfectants of examples and comparative examples, and the ratio of the number of bacteria before and after disinfection/the change in the titer of the virus was calculated to obtain the sterilization rate and the killing rate, and the tests were repeated 3 times each, and the average value was shown in Table 1.
Table 1 results of the sterilization test of the complex quaternary ammonium salt sterilization disinfectant
The composite quaternary ammonium salt provided by the invention consists of single-chain quaternary ammonium salt and double-chain quaternary ammonium salt, and the disinfection and sterilization performances of the composite quaternary ammonium salt are superior to those of the single-chain quaternary ammonium salt and the double-chain quaternary ammonium salt; the double-chain quaternary ammonium salt contains two long-chain hydrophobic groups and two positively charged N in the structure + Through the induction, the positive charge density of quaternary nitrogen is increased, and the adsorption capacity of the disinfectant on the surface of bacteria is increased, so that the permeability of the film is changed, and the thalli are broken, so that the sterilization spectrum of the disinfectant can be effectively enlarged, and the sterilization effect can be enhanced; the nonionic surfactant molecules are inserted between the polar head groups of the ionic surfactant by means of hydrophobic interaction and interaction between the polar head groups, so that the charge density is improved, the bactericidal effect of the quaternary ammonium salt is enhanced, and the effect is improved. However, when a certain disinfectant is used alone for a long time for surface disinfection, the surface disinfection also generates antibiosis resistance, so that a plant bacteriostasis and sterilization preparation is introduced to obtainThe technical scheme of the embodiment 1 adopts the combination of quaternary ammonium salt and natural biological bacteriostat to improve the environmental problems, improve the bacteriostasis and disinfection problems and improve the antibacterial resistance. The quaternary ammonium salt sterilizing disinfectant prepared in the embodiment 1 has the sterilizing and disinfecting effect of 99.99% after 1 day of sterilization. In example 1, effective molecules in raspberry extract and tea tree extract mostly contain active groups, can react with odor molecules, and can achieve good deodorizing and sterilizing performance through synergistic effect of various raw materials. The plant extract has deodorizing effect on the environment in the sterilization process, has strong adsorption effect, can be combined with harmful gases such as ammonia, hydrogen sulfide, methylindole and the like, reduces the concentration of the harmful gases, further improves the peculiar smell, and plays a certain role in deodorizing, sterilizing and disinfecting. In order to solve the problems that active substances are easy to oxidize and volatilize and cannot exert the effect of the active substances for a long time, the microcrystalline cellulose and the hydroxyapatite adopted by the invention have the characteristics of low cost, excellent biocompatibility, environmental friendliness, degradation and the like on the basis of the embodiment 1; however, the aerogel loaded with the plant extract has poor compatibility in disinfectant, is easy to precipitate, and the plant extract is easy to desorb and disperse in the disinfectant, so that the slow release, long-term antibacterial, deodorizing and disinfecting performances of the aerogel are affected; the aerogel loaded with the plant extract is further taken as a matrix, and is wrapped by sodium alginate, chitosan quaternary ammonium salt and calcium chloride, so that the slow release performance is improved, and the effects of resisting bacteria, sterilizing and deodorizing are prolonged; the plant extract microgel prepared by the invention can well interact with active ingredients in the disinfectant, the wall material of the microgel is slowly decomposed in the disinfectant, the microgel has long-term stability, and meanwhile, the disinfectant has lasting antibacterial, disinfecting, deodorizing and other effects, so that the technical scheme of the embodiment 2 is obtained, and the sterilizing/bacteriostasis effect is improved.
The plant-derived bacteriostat adopted in example 5 is formed by mixing plant extracts and plant extract microcapsules, and the plant extract microcapsules can solve the problem of performance disappearance or performance reduction after volatilization of the plant extracts, and simultaneously maintain persistent sterilization/bacteriostasis and improve air.
Test example 2
Under the condition of (30+/-1) DEG C, the disinfectant has the effect of removing the bad gases of ammonia and hydrogen sulfide.
The initial concentration of ammonia gas and hydrogen sulfide was 60ppm, which was recorded as 100%, and the final concentration of hydrogen sulfide was measured 120min after the addition of the prepared solution.
Table 2 test results for removing off-flavors
In example 1, effective molecules in raspberry extract and tea tree extract mostly contain active groups, can react with odor molecules, and can achieve good deodorizing and sterilizing performance through synergistic effect of various raw materials. The plant extract has deodorizing effect on the environment in the sterilization process, has strong adsorption effect, can be combined with harmful gases such as ammonia, hydrogen sulfide, methylindole and the like, reduces the concentration of the harmful gases, further improves the peculiar smell, and plays a certain role in deodorizing, sterilizing and disinfecting. The compound quaternary ammonium salt sterilizing disinfectant prepared by the invention simultaneously introduces the mutual synergistic effect among double-chain quaternary ammonium salt, single-chain quaternary ammonium salt, plant extract and plant extract microcapsule substances, further strengthens the sterilizing effect and has wider sterilizing range; the plant extract microcapsule introduces the functions of prolonging the antibacterial, sterilizing and deodorizing.
Test example 3
14 New Zealand rabbits with the weight of 2-3kg are selected, and the male and female animals are not limited. Referring to 2002 edition of disinfection Specification, skin irritation test was performed with New Zealand rabbits; the hairs on both sides of the animal back were cut off 24 hours before the test, to a range of 3cm 2 . The next day 0.2mL of the test disinfectant was dropped onto 2.5cm 2 And applying the gauze on one side of the gauze with the size of 2 layers on the skin surface, covering the gauze with a layer of non-irritating oilpaper, and fixing the gauze with the non-irritating adhesive tape. The other side served as a blank (or solvent control),acting for 4 hours, and then washing off residual test objects by warm water; the local skin reactions were observed and scored 1h, 24h, and 48h after removal of the test subjects, respectively. The results show that the disinfectants prepared in examples 1-7 act on rabbit skin for 4 hours without causing animal skin irritation reaction and skin irritation index<0.4, the stimulation intensity is non-stimulating.
The disinfectant prepared by the invention has the advantages of mild formula, no stimulation to human body, no harm to human body, health and environmental protection, and is environment-friendly.
The foregoing describes in detail preferred embodiments of the present invention. It should be understood that numerous modifications and variations can be made in accordance with the concepts of the invention by one of ordinary skill in the art without undue burden. Therefore, all technical solutions which can be obtained by logic analysis, reasoning or limited experiments based on the prior art by the person skilled in the art according to the inventive concept shall be within the scope of protection defined by the claims.
Claims (10)
1. The composite quaternary ammonium salt sterilizing disinfectant is characterized by comprising the following raw materials in percentage by mass: 0.2-2% of compound quaternary ammonium salt, 0.1-1% of amine substance, 0.1-5% of nonionic surfactant, 0.1-2% of hydroxyethyl cellulose, 12-16% of absolute ethyl alcohol and the balance of water.
2. The composite quaternary ammonium salt disinfectant according to claim 1, wherein the nonionic surfactant is one or a mixture of a plurality of dodecyl dihydroxyethyl amine oxide and cocoalkyl dihydroxyethyl amine oxide.
3. The composite quaternary ammonium salt disinfectant according to claim 1, wherein the composite quaternary ammonium salt is a mixture of double-chain quaternary ammonium salt and single-chain quaternary ammonium salt.
4. The composite quaternary ammonium salt disinfectant and disinfectant according to claim 3, wherein the double-chain quaternary ammonium salt is at least one of decylmethylammonium chloride, decylmethylammonium bromide, dioctyl dimethyl ammonium chloride, dioctadecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, ditetradecyl dimethyl ammonium chloride, 2- (2-phenoxyethoxy) ethyl trimethyl ammonium chloride;
the single-chain quaternary ammonium salt is at least one of benzalkonium bromide, benzalkonium chloride, benzethonium chloride, tetradecyldimethylbenzyl ammonium chloride, dodecyl dimethylbenzyl ammonium chloride, octadecyl trimethyl ammonium chloride and dodecyl trimethyl ammonium chloride.
5. The composite quaternary ammonium salt sterilizing disinfectant according to claim 3, wherein the composite quaternary ammonium salt is formed by mixing (1-3) of decylmethylamine and benzethonium chloride according to the mass ratio of (1-3).
6. The composite quaternary ammonium salt disinfectant according to claim 1, further comprising a plant-derived bacteriostatic agent.
7. The composite quaternary ammonium salt disinfectant according to claim 6, wherein the plant-derived bacteriostatic agent is a plant extract.
8. The composite quaternary ammonium salt disinfectant according to claim 6, wherein the plant-derived bacteriostatic agent may also be a plant extract microcapsule.
9. The composite quaternary ammonium salt disinfectant according to claim 7, wherein the plant extract is at least one of tea tree extract, sweet orange peel extract, peppermint extract, clove extract, lemon extract, raspberry extract.
10. A method for preparing the composite quaternary ammonium salt sterilizing disinfectant according to any one of claims 1-9, which is characterized in that the composite quaternary ammonium salt sterilizing disinfectant is prepared by uniformly stirring and mixing composite quaternary ammonium salt, amine substances, nonionic surfactant, plant-derived bacteriostat, hydroxyethyl cellulose, absolute ethyl alcohol and water according to a formula.
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