CN117462624A - Novel anticancer Chinese medicinal compound preparation and preparation method thereof - Google Patents
Novel anticancer Chinese medicinal compound preparation and preparation method thereof Download PDFInfo
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- CN117462624A CN117462624A CN202311374554.3A CN202311374554A CN117462624A CN 117462624 A CN117462624 A CN 117462624A CN 202311374554 A CN202311374554 A CN 202311374554A CN 117462624 A CN117462624 A CN 117462624A
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Abstract
The invention discloses a novel anticancer traditional Chinese medicine compound preparation and a preparation method thereof. The key points of the technical scheme are as follows: comprises the following components: radix et rhizoma Boehmeriae, ganoderma, maitake Mushroom, lentinus Edodes, hericium Erinaceus, poria, taxus chinensis, radix astragali, radix Ginseng, rhizoma Bletillae, herba Hedyotidis Diffusae, and Glycyrrhrizae radix. The invention has strong operability and controllable quality, the prescription is favorable for playing the anticancer effect of various medicinal materials such as the root of the Chinese wild peach, the anticancer active ingredients in the prescription are stable, the product is stable, various in vivo and in vitro experiments prove that the invention has higher tumor inhibition rate, can obviously improve the immunity of organisms, has definite antitumor effect, can improve the curative effect of the chemotherapeutic by being combined with the chemotherapeutic, can reduce the toxicity of the chemotherapeutic, and has better anticancer clinical effect in clinical application.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compound preparations, in particular to a novel anti-cancer traditional Chinese medicine compound preparation and a preparation method thereof.
Background
There are several side effects of mainstream chemotherapeutics: (1) local reaction. Some more irritating chemotherapeutics can cause serious local reactions when being injected intravenously, and are mainly characterized by phlebitis and local tissue necrosis; (2) myelosuppression. (3) immunosuppression. When immune function is reduced, tumor cells are easy to spread, and the recurrence or metastasis process can be accelerated; (4) multiple organ injury. Such as cardiotoxicity, nephrotoxicity, gastrointestinal toxicity, etc.
Targeted therapies still present a number of bottlenecks: (1) is costly. Although most targeted therapeutic drugs have been incorporated into national medical insurance, the pressure on individuals and socioeconomic performance of targeted drugs is greater than that of traditional chemotherapeutic drugs; (2) off-target effects and targeted extracellular toxicity. The most common adverse reactions are rash, diarrhea, canker sores, etc.; (3) drug resistance phenomenon. Genomic instability leads to tumor heterogeneity under endogenous and exogenous stress, and is manifested as a change in the target. In addition, immature vasculature, high interstitial fluid pressure, and abundant extracellular matrix and tumor-associated stromal cells in tumor microenvironments, etc. become an insurmountable barrier for drug targeting.
Under the condition that the existing drug treatment falls into the dead office, the experience of treating tumors is drawn from the ancient traditional Chinese medicine. The traditional Chinese medicine is developed based on the guidance of the traditional Chinese medicine theory, and artemisinin and the like prove the huge potential and wide prospect of the traditional Chinese medicine.
In the tumor treatment process, the traditional Chinese medicine compound can fully mobilize epidemic prevention mechanisms of organisms, plays a multi-target, multi-layer and multi-link comprehensive regulation and control role, and has remarkable advantages in the aspects of inhibiting tumor occurrence and development, improving the life quality of tumor patients, prolonging the survival period and the like. The traditional Chinese medicine compound takes monarch, minister, assistant and guide as a compatibility rule, and the treatment emphasizes the concept of unity, but because of the multiple chemical components, multiple group forms, complex pharmacological mechanism and multiple interference factors, the mutual connection and influence understanding among multiple links and multiple targets of the traditional Chinese medicine compound are not deep enough, so that the research progress is slow and the international acceptance degree is lower.
There is therefore a need to propose a solution to this problem.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a novel anticancer traditional Chinese medicine compound preparation and a preparation method thereof.
The technical aim of the invention is realized by the following technical scheme: an anticancer Chinese medicinal compound preparation and its preparation method, comprising the following components: radix et rhizoma Boehmeriae, ganoderma, maitake Mushroom, lentinus Edodes, hericium Erinaceus, poria, taxus chinensis, radix astragali, radix Ginseng, rhizoma Bletillae, herba Hedyotidis Diffusae, and Glycyrrhrizae radix.
The invention is further provided with: comprises the following components in parts by weight: 90-135g of white mountain wild peach root, 6-13g of lucid ganoderma, 7-12g of grifola frondosa, 6-14g of mushroom, 8-10g of hericium erinaceus, 5-11g of poria cocos, 7-11g of Chinese yew, 4-8g of astragalus mongholicus, 5-13g of sun-dried ginseng, 2-16g of bletilla striata, 9-14g of oldenlandia diffusa and 3-10g of liquorice.
The invention is further provided with: the method comprises the following steps: s1: weighing the raw materials required by the preparation according to the weight ratio, and carrying out fractional extraction on the symmetrically-taken raw materials, wherein water extraction, alcohol extraction and Supercritical (SCF) extraction are combined to obtain an extract;
s2: purifying the extract by membrane coupling, nanofiltration coupling and chromatographic separation to obtain purified powder extract.
The method for preparing the anticancer new traditional Chinese medicine compound preparation according to claim 3, which is characterized in that: the powdery extract in the step S2 is added with a proper amount of auxiliary materials, and can be prepared into capsules, tablets, granules and pills by a conventional process.
The invention is further provided with: the operation steps of the water extraction in the step S1 are as follows: pulverizing the raw materials into coarse powder with a size of more than 10 meshes, decocting the coarse powder with water for 3-4 times, mixing the water decoction, filtering, concentrating the filtrate under reduced pressure at a temperature of not more than 60 ℃, and freeze-drying to obtain the effective substance group for water extraction of the raw materials.
The technical aim of the invention is also achieved by the following technical scheme: a preparation method of a new anticancer Chinese medicinal compound preparation comprises the following steps: the alcohol extraction operation in the step S1 comprises the following steps: the starting materials were placed in a 2000mL round bottom flask at 1: adding 1000ml of deionized water in a weight ratio of 10, reflux-extracting for 2-4 times, each time for 1-2 hours, filtering while the solution is hot, concentrating the filtrate, fixing the volume in a 50ml volumetric flask, adding water to the scale to obtain a traditional Chinese medicine extract, adding 95% ethanol into the traditional Chinese medicine extract, stirring while adding the ethanol to make the ethanol content 80%, standing overnight for 24 hours, decompressing and filtering to obtain a precipitate, decompressing and drying the precipitate, and grinding to obtain the raw material ethanol extraction active substance group.
The invention is further provided with: the supercritical extraction in the step S1 comprises the following steps: the raw materials are put into an extraction kettle for supercritical fluid extraction.
In summary, the invention has the following beneficial effects:
the preparation method has strong operability and controllable quality, the prescription is favorable for playing the anticancer effects of various medicinal materials such as the root of the wild peach and the like, the anticancer active ingredients in the prescription are stable, the product is stable, various in vivo and in vitro experiments prove that the preparation has higher tumor inhibiting rate, can obviously improve the immunity of organisms, has definite antitumor effect, can improve the curative effect of the chemotherapeutic by being combined with the chemotherapeutic, can reduce the toxicity of the chemotherapeutic, has better anticancer clinical effect in clinical application, is suitable for patients with tumors in various periods to be used as antitumor auxiliary therapeutic agents, and the combined use of the anabolic therapeutic agents can play roles of synergism, attenuation, improvement of life quality and the like, and the prepared preparation has obvious effect and convenient application.
Detailed Description
In order to better understand the technical solution of the present invention for a person skilled in the art, the present invention will be described in further detail with reference to specific embodiments, and it should be noted that embodiments of the present invention and features in the embodiments may be combined with each other without conflict.
In the description of the present invention, it should be noted that the terms "upper," "lower," "inner," "outer," "top/bottom," and the like indicate orientations or positional relationships merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements being referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "provided," "sleeved," "connected," and the like are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
The present invention will be described in detail below.
An anticancer Chinese medicinal compound preparation and its preparation method, comprising the following components: radix et rhizoma Boehmeriae, ganoderma, maitake Mushroom, lentinus Edodes, hericium Erinaceus, poria, taxus chinensis, radix astragali, radix Ginseng, rhizoma Bletillae, herba Hedyotidis Diffusae, and Glycyrrhrizae radix.
Comprises the following components in parts by weight: 90-135g of white mountain wild peach root, 6-13g of lucid ganoderma, 7-12g of grifola frondosa, 6-14g of mushroom, 8-10g of hericium erinaceus, 5-11g of poria cocos, 7-11g of Chinese yew, 4-8g of astragalus mongholicus, 5-13g of sun-dried ginseng, 2-16g of bletilla striata, 9-14g of oldenlandia diffusa and 3-10g of liquorice.
Wherein, the root of the wild peach is a monarch drug, the Zhejiang big gun is she drug, which is the national medical feature in Zhejiang area, is widely distributed in Zhejiang, has abundant medicinal material resources, and is recorded in Tang 'Ben Caoshiyi' Song 'Ben Cao Yi' and Ming 'Ben Cao Chao mu'. Mainly contains triterpene, flavone, sterol, saccharide, trace elements, volatile oil, lignan and other components, and has obvious pharmacological effects of resisting tumor, regulating immunity, resisting inflammation, resisting oxidation and the like. The traditional Chinese medicine is the dried root of actinidia arguta of actinidia chinensis planch. The nature and flavor are mild, slightly pungent and cold. Enter liver, large intestine and stomach meridians. Function and main indications: clearing away heat and toxic materials, promoting diuresis and relieving swelling. Can be used for treating carbuncle due to heat toxin, acute mastitis, tympanites, rheumatalgia, and traumatic injury. Is used to treat tumor. In recent decades, the traditional Chinese medicine composition is used for treating cancers, has remarkable effect, and particularly has more obvious effect in the later stage of cancers. Through investigation, the Chinese medicinal composition can achieve better treatment effect and prolong life for cancer patients taking the root of the Chinese wild peach as a main monarch drug. According to a large number of medical records, the white mountain wild peach root has obvious effect only when the patient has 100 g of medicinal materials per day. The prescription takes the root of the Chinese wild peach as the monarch drug, and the dosage of the raw medicinal materials exceeds forty percent of the dosage of the total prescription raw medicinal materials, so the prescription is named she drug and shows the national medical characteristics. In the ancient classical prescription of China, the dosage of the monarch drug is more than 125 g, which accords with the medication habit and uses strong drugs for serious symptoms;
six ingredients of taxus chinensis, ganoderma lucidum, grifola frondosa, mushroom, hericium erinaceus and oldenlandia are used as ministerial drugs. Yew is received from Zhejiang province Chinese medicine preparation Specification. The nature and flavor are slightly sweet, bitter and flat. It has little toxicity and enters kidney and heart meridians. Function and main indications: detumescence, resolving hard mass, dredging channels and promoting urination. Mass, edema, dysuria, rheumatalgia, etc. The traditional Chinese medicine composition is used for resisting tumors, has the efficacy of resisting cancer, has the components of taxol, and is a common clinical chemotherapeutic medicine. Although the dosage of the medicinal materials is controlled within a safe range in one day, clinical practice and laboratory practice prove that the medicinal materials are ideal anticancer drugs, and have the effects of inhibiting the growth and proliferation of tumor cells and inducing the apoptosis of the tumor cells. Hedyotidis Diffusae is sweet, light and cool in nature and enters lung channel, large intestine channel and small intestine channel, and is mainly indicated for pain, swelling and vesicular toxicity, snake venom bite, heat stranguria and pain. The traditional Chinese medicine composition is also used for treating cancers at present, and is widely used for various anticancer treatments such as digestive system tumors, reproductive system tumors, respiratory system tumors, bone marrow and the like;
the four edible and medicinal fungi of ganoderma lucidum, grifola frondosa, lentinus edodes and hericium erinaceus comprise edible fungus polysaccharide and triterpene, and are four known anticancer fungi. According to research, the active polysaccharide component beta-D (1-73) glucose of medicinal bacteria has a change to heterologous, homologous and even genetic tumors. Meanwhile, the fungus polysaccharide is an immune activator, can enhance the immunity of organisms, is a substance beneficial to human bodies, has low immunity for cancer patients, supplements the edible and medicinal fungus active polysaccharide, enhances the immunity and overcomes the survival rate of cancer cells. The ganoderma triterpene can be used as an auxiliary therapeutic agent for tumor radiotherapy and chemotherapy, and can improve cachexia of tumor patients, promote hematopoietic function of bone marrow, strengthen physique, improve immune function of tumor patients and strengthen anti-tumor immunity of antibodies.
In the recipe, astragalus root, ginseng, poria cocos, amomum fruit and bletilla tuber are used as auxiliary materials. Astragalus root, ginseng and poria cocos are used for reinforcing primordial qi, strengthening middle-jiao and replenishing qi, nourishing blood and tranquillizing, strengthening spleen and nourishing stomach, and promoting diuresis and removing dampness. The Hericium erinaceus in fructus amomi, bletilla striata and ministerial drugs has the effects of resolving dampness and stimulating appetite, promoting qi circulation and removing food retention, and Wen Weiwen spleen, and overcomes the defect of cold root and stomach of the white wild peach in monarch drug. The rhizoma bletilla is used for astringing and stopping bleeding, detumescence and promoting granulation, and promoting blood circulation for removing blood stasis. Improving uncomfortable phenomenon of the patient eating the root and stomach of the white mountain wild peach. The five auxiliary medicines have the effects of tonifying qi and soothing nerves, stimulating appetite and benefiting spleen, and further improve the diet and life quality of cancer patients. In the formula, licorice is used as a guiding drug, licorice is used for detoxifying and regulating the 'Baiyaowang' of the crowded drug, and the actions of the drugs are regulated to ensure that the medicines form resultant force to resist cancers.
The absorption of the anticancer mixture 13 she/Chinese medicine composition concentrates the experiences of anticancer patients in the places where the white mountain wild peach root grows in south province for decades. One monarch drug and six ministerial drugs are used for removing cancer toxin, removing blood stasis and resolving masses; has effects of inhibiting tumor cell growth and proliferation, inducing tumor cell apoptosis, inhibiting tumor angiogenesis, and inhibiting tumor cell telomerase activity. The adjuvant drugs have five flavors of tonifying qi and soothing nerves, stimulating appetite and benefiting spleen, and improving physique of patients. Strengthening body resistance to remove toxic substances, thereby achieving the aim of treating cancer
The method comprises the following steps: s1: weighing the raw materials required by the preparation according to the weight ratio, and carrying out fractional extraction on the symmetrically-taken raw materials, wherein water extraction, alcohol extraction and Supercritical (SCF) extraction are combined to obtain an extract;
s2: purifying the extract by membrane coupling, nanofiltration coupling and chromatographic separation to obtain purified powder extract.
The method for preparing the anticancer new traditional Chinese medicine compound preparation according to claim 3, which is characterized in that: the powdery extract in the step S2 is added with a proper amount of auxiliary materials, and can be prepared into capsules, tablets, granules and pills by a conventional process.
The operation steps of the water extraction in the step S1 are as follows: pulverizing the raw materials into coarse powder with a size of more than 10 meshes, decocting the coarse powder with water for 3-4 times, mixing the water decoction, filtering, concentrating the filtrate under reduced pressure at a temperature of not more than 60 ℃, and freeze-drying to obtain the effective substance group for water extraction of the raw materials.
The alcohol extraction operation in the step S1 comprises the following steps: the starting materials were placed in a 2000mL round bottom flask at 1: adding 1000ml of deionized water in a weight ratio of 10, reflux-extracting for 2-4 times, each time for 1-2 hours, filtering while the solution is hot, concentrating the filtrate, fixing the volume in a 50ml volumetric flask, adding water to the scale to obtain a traditional Chinese medicine extract, adding 95% ethanol into the traditional Chinese medicine extract, stirring while adding the ethanol to make the ethanol content 80%, standing overnight for 24 hours, decompressing and filtering to obtain a precipitate, decompressing and drying the precipitate, and grinding to obtain the raw material ethanol extraction active substance group.
The supercritical extraction in the step S1 comprises the following steps: the raw materials are put into an extraction kettle for supercritical fluid extraction.
The method comprises the steps of carrying out fractional extraction, water extraction, alcohol extraction and Supercritical (SCF) extraction, carrying out process purification by adopting membrane coupling, nanofiltration coupling and chromatographic separation, carrying out systematic characterization on chemical components of the extract by combining biological activity evaluation with TLC and fingerprint screening optimal processes, and carrying out network pharmacology screening on the medicinal components to determine the basis of the medicinal substances;
the transcriptome is combined with proteome and metabonomics technology and means to analyze the action target point and molecular mechanism of the five-positive mixture, and finally the main functional substances with the functions of the five-positive mixture are disadvantageous. And the extraction technology is preferably selected by comparing and evaluating the content and activity of the functional substances with the means of semi-bionic extraction, ultrasonic extraction, supercritical fluid extraction, cyclone extraction, pressurized countercurrent extraction, enzymatic extraction, membrane coupling, nanofiltration coupling, chromatographic separation and the like. The composition and the preparation process of the admixture are scientifically screened and optimized by comprehensively screening and optimizing the composition, the proportion and the preparation process conditions of the admixture by combining the investigation of the solubility, the stability, the content of the functional substances and the pharmacodynamic activity;
the preparation method has the advantages that the operability of the production process is strong, the quality is controllable, the prescription is favorable for playing the anticancer effects of various medicinal materials such as the root of the wild peach and the like, the anticancer active ingredients in the prescription are stable, the product is stable, various in vivo and in vitro experiments prove that the preparation has higher tumor inhibiting rate, can obviously improve the immunity of organisms, has definite antitumor effect, can improve the curative effect of the chemotherapeutic by being combined with the chemotherapeutic, can reduce the toxicity of the chemotherapeutic, has better anticancer clinical effect in clinical application, is suitable for patients with tumors in various periods to be used as antitumor auxiliary therapeutic agents, can play roles of synergism, attenuation, improvement of the life quality and the like in combination of the anabolic therapeutic agents, and has obvious prepared preparation effect and convenient application.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above examples, and all technical solutions belonging to the concept of the present invention belong to the protection scope of the present invention. It should be noted that modifications and adaptations to the present invention may occur to one skilled in the art without departing from the principles of the present invention and are intended to be within the scope of the present invention.
Claims (7)
1. An anticancer new traditional Chinese medicine compound preparation is characterized in that: comprises the following components: radix et rhizoma Boehmeriae, ganoderma, maitake Mushroom, lentinus Edodes, hericium Erinaceus, poria, taxus chinensis, radix astragali, radix Ginseng, rhizoma Bletillae, herba Hedyotidis Diffusae, and Glycyrrhrizae radix.
2. The novel anticancer Chinese herbal compound preparation according to claim 1, wherein: comprises the following components in parts by weight: 90-135g of white mountain wild peach root, 6-13g of lucid ganoderma, 7-12g of grifola frondosa, 6-14g of mushroom, 8-10g of hericium erinaceus, 5-11g of poria cocos, 7-11g of Chinese yew, 4-8g of astragalus mongholicus, 5-13g of sun-dried ginseng, 2-16g of bletilla striata, 9-14g of oldenlandia diffusa and 3-10g of liquorice.
3. The method for preparing the novel anticancer Chinese herbal compound preparation according to any one of claims 1 to 2, which is characterized in that: the method comprises the following steps: s1: weighing the raw materials required by the preparation according to the weight ratio, and carrying out fractional extraction on the symmetrically-taken raw materials, wherein water extraction, alcohol extraction and Supercritical (SCF) extraction are combined to obtain an extract;
s2: purifying the extract by membrane coupling, nanofiltration coupling and chromatographic separation to obtain purified powder extract.
4. The method for preparing the anticancer new traditional Chinese medicine compound preparation according to claim 3, which is characterized in that: the powdery extract in the step S2 is added with a proper amount of auxiliary materials, and can be prepared into capsules, tablets, granules and pills by a conventional process.
5. The method for preparing the anticancer new traditional Chinese medicine compound preparation according to claim 3, which is characterized in that: the operation steps of the water extraction in the step S1 are as follows: pulverizing the raw materials into coarse powder with a size of more than 10 meshes, decocting the coarse powder with water for 3-4 times, mixing the water decoction, filtering, concentrating the filtrate under reduced pressure at a temperature of not more than 60 ℃, and freeze-drying to obtain the effective substance group for water extraction of the raw materials.
6. The method for preparing the anticancer new traditional Chinese medicine compound preparation according to claim 3, which is characterized in that: the alcohol extraction operation in the step S1 comprises the following steps: the starting materials were placed in a 2000mL round bottom flask at 1: adding 1000ml of deionized water in a weight ratio of 10, reflux-extracting for 2-4 times, each time for 1-2 hours, filtering while the solution is hot, concentrating the filtrate, fixing the volume in a 50ml volumetric flask, adding water to the scale to obtain a traditional Chinese medicine extract, adding 95% ethanol into the traditional Chinese medicine extract, stirring while adding the ethanol to make the ethanol content 80%, standing overnight for 24 hours, decompressing and filtering to obtain a precipitate, decompressing and drying the precipitate, and grinding to obtain the raw material ethanol extraction active substance group.
7. The method for preparing the anticancer new traditional Chinese medicine compound preparation according to claim 3, which is characterized in that: the supercritical extraction in the step S1 comprises the following steps: the raw materials are put into an extraction kettle for supercritical fluid extraction.
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