CN117412744A - Skin care product and process for its production - Google Patents
Skin care product and process for its production Download PDFInfo
- Publication number
- CN117412744A CN117412744A CN202280039737.7A CN202280039737A CN117412744A CN 117412744 A CN117412744 A CN 117412744A CN 202280039737 A CN202280039737 A CN 202280039737A CN 117412744 A CN117412744 A CN 117412744A
- Authority
- CN
- China
- Prior art keywords
- equal
- lipid
- lipid particle
- fatty acids
- wax
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- 238000000034 method Methods 0.000 title claims description 16
- 230000008569 process Effects 0.000 title claims description 6
- 150000002632 lipids Chemical class 0.000 claims abstract description 95
- 239000002245 particle Substances 0.000 claims abstract description 76
- 239000003642 reactive oxygen metabolite Substances 0.000 claims abstract description 35
- 239000011159 matrix material Substances 0.000 claims abstract description 27
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 21
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 19
- 230000000699 topical effect Effects 0.000 claims abstract description 7
- 235000006708 antioxidants Nutrition 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 20
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 18
- 239000004480 active ingredient Substances 0.000 claims description 17
- 239000000839 emulsion Substances 0.000 claims description 16
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 11
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 10
- 239000011630 iodine Substances 0.000 claims description 10
- 229910052740 iodine Inorganic materials 0.000 claims description 10
- 238000002844 melting Methods 0.000 claims description 9
- 230000008018 melting Effects 0.000 claims description 9
- 238000009825 accumulation Methods 0.000 claims description 8
- 239000006185 dispersion Substances 0.000 claims description 8
- 239000000758 substrate Substances 0.000 claims description 8
- 235000011468 Albizia julibrissin Nutrition 0.000 claims description 7
- 240000005852 Mimosa quadrivalvis Species 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 235000020238 sunflower seed Nutrition 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 6
- 229930003268 Vitamin C Natural products 0.000 claims description 6
- 239000008346 aqueous phase Substances 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 6
- 229920000223 polyglycerol Polymers 0.000 claims description 6
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000000375 suspending agent Substances 0.000 claims description 6
- 235000019154 vitamin C Nutrition 0.000 claims description 6
- 239000011718 vitamin C Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 239000003906 humectant Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical group CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 4
- 240000003770 Stephanotis floribunda Species 0.000 claims description 4
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 4
- 229940119170 jojoba wax Drugs 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 241000221095 Simmondsia Species 0.000 claims description 3
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- FSEJJKIPRNUIFL-UHFFFAOYSA-N [2,2-bis(hydroxymethyl)-3-octadecanoyloxypropyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)(CO)COC(=O)CCCCCCCCCCCCCCCCC FSEJJKIPRNUIFL-UHFFFAOYSA-N 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 230000000799 fusogenic effect Effects 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 238000005809 transesterification reaction Methods 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 2
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 2
- -1 alkyl glucosides Chemical class 0.000 claims description 2
- 235000021466 carotenoid Nutrition 0.000 claims description 2
- 150000001747 carotenoids Chemical class 0.000 claims description 2
- 229930182478 glucoside Natural products 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 2
- 235000013824 polyphenols Nutrition 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 229940068965 polysorbates Drugs 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 244000063464 Vitex agnus-castus Species 0.000 claims 1
- 235000009347 chasteberry Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000001993 wax Substances 0.000 description 16
- 230000006378 damage Effects 0.000 description 6
- 239000006210 lotion Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000003859 lipid peroxidation Effects 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 206010063493 Premature ageing Diseases 0.000 description 2
- 208000032038 Premature aging Diseases 0.000 description 2
- 235000019485 Safflower oil Nutrition 0.000 description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 229910001882 dioxygen Inorganic materials 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 229960004488 linolenic acid Drugs 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 235000005713 safflower oil Nutrition 0.000 description 2
- 239000003813 safflower oil Substances 0.000 description 2
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 description 2
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- SQYJRUFNBSYSAI-AZUAARDMSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hexadecoxy-4-hydroxy-2h-furan-5-one Chemical compound CCCCCCCCCCCCCCCCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO SQYJRUFNBSYSAI-AZUAARDMSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- VUWCWMOCWKCZTA-UHFFFAOYSA-N 1,2-thiazol-4-one Chemical class O=C1CSN=C1 VUWCWMOCWKCZTA-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 244000236161 Acacia decurrens Species 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- 108020005196 Mitochondrial DNA Proteins 0.000 description 1
- 108091093105 Nuclear DNA Proteins 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 244000248021 Vitex negundo Species 0.000 description 1
- 235000010363 Vitex negundo Nutrition 0.000 description 1
- OEWBEINAQKIQLZ-CMRBMDBWSA-N [(2s)-2-[(2r)-3,4-bis(2-hexyldecanoyloxy)-5-oxo-2h-furan-2-yl]-2-(2-hexyldecanoyloxy)ethyl] 2-hexyldecanoate Chemical compound CCCCCCCCC(CCCCCC)C(=O)OC[C@H](OC(=O)C(CCCCCC)CCCCCCCC)[C@H]1OC(=O)C(OC(=O)C(CCCCCC)CCCCCCCC)=C1OC(=O)C(CCCCCC)CCCCCCCC OEWBEINAQKIQLZ-CMRBMDBWSA-N 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 229940067599 ascorbyl glucoside Drugs 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229940073499 decyl glucoside Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- MDKXBBPLEGPIRI-UHFFFAOYSA-N ethoxyethane;methanol Chemical compound OC.CCOCC MDKXBBPLEGPIRI-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 239000002539 nanocarrier Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 125000000864 peroxy group Chemical group O(O*)* 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000006950 reactive oxygen species formation Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000037370 skin discoloration Effects 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000002047 solid lipid nanoparticle Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention is a lipid particle and a method for producing the same. The lipid particle comprises a matrix and at least one antioxidant incorporated into the matrix. In one embodiment of the invention, the lipid particles are used to locally inhibit ROS in the skin of a patient ("reactive oxygen species"). In one embodiment of the invention, a skin care product comprising the lipid particles is used for topical inhibition of ROS in the skin of a patient.
Description
Technical Field
The present invention relates to lipid particles, in particular for use in skin care products.
Background
Recently, skin care products such as creams, lotions or essences have become widespread, which consist of a fluid substance, usually a gel, incorporating lipid particles containing one or more molecules of cosmetic active ingredients.
Examples of such active ingredients are vitamins, such as for example vitamin A, C, E and its derivatives, coenzyme Q10, minerals, antioxidants, natural extracts and peptides.
Among the factors known to cause skin damage are the so-called "free radicals". These are responsible for lipid peroxidation. Among these, so-called ROS (reactive oxygen species), which contain electron-deficient molecular oxygen ("peroxy"), in particular, cause damage in excess, the most serious of which is premature aging of the skin.
During lipid peroxidation, lipids containing unsaturated fatty acids and esters thereof are oxidized directly by molecular oxygen, and damage can propagate through the chain reaction, since electron-deprived lipids tend to re-integrate lost by subtracting electrons from neighboring molecules, even involving proteins and DNA of the central core.
Thus, after these reactions, some possible damage is: lipid peroxidation, peroxidation of amino acids and proteins, enzymatic changes and damage to protein structure.
ROS produced in mitochondria can react and directly damage mtDNA and other mitochondrial components. ROS can also damage nuclear DNA.
For all these reasons, oxidative modification of some proteins may be an important aging factor. Thus, products containing antioxidant active ingredients capable of interacting with ROS and inhibiting its activity are known and widespread. For example, these products are commercialized as:
-derm internes 10% pure vitamin C (L' Or al Paris),
resveratrol B E antioxidant night concentrates (Skincents)
High-grade multiple-protection antioxidant skin lotion SPF 15 (Estee Lauder)
Anteolos AOX daytime antioxidant essence (La Roche-Posay) containing sunscreens
However, products available today for reducing ROS in skin have limitations. For example, these products, while containing active ingredients that are sensitive to ROS, have the disadvantage that the active ingredients are in a free state or incorporated into lipid particles with a stable matrix, i.e. a containment envelope (containment envelope), designed to protect the content or to carry the content in a controlled and specific manner but without affinity for ROS.
Such matrices are generally composed mainly of saturated polymers and/or lipids that are stable to oxidation (Comunian et al, "Protection and controlled release of vitamin C by different micro/nanocarriers", crit Rev Food Sci Nutr.2020, 12 months 22; 1-22).
The purpose of the matrix used in the products known so far is to protect the incorporated active ingredients, making them more bioavailable, i.e. able to reach the circulatory system, and to increase skin penetration and gradual release.
For these reasons, however, the activity of the active ingredient is equally represented over the whole area of skin to which the product is applied, irrespective of the local concentration of ROS, and not preferentially in areas of higher ROS concentration, which would be of greater demand.
Furthermore, in order to produce similar products, it is necessary to use organic solvents such as methylene chloride, chloroform, diethyl ether and ether-methanol mixtures, which may be toxic, or to use high temperatures above 60℃and up to 100℃ (Ghasemieh et al, "Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages", res Pharm Sci.2018, month 8; 13 (4): 288-303). This results in an economically and energy-intensive process.
Disclosure of Invention
In view of the limitations of the prior art described above, a primary object of the present invention is to provide a skin care product and method of manufacturing the same that can improve upon the prior art with respect to one or more of the above aspects.
Within this aim, an object of the present invention is to provide lipid particles which have a high sensitivity to ROS and which are capable of delivering active ingredients incorporated therein to areas with ROS, and in particular those areas with a higher ROS concentration.
It is another object of the present invention to provide a skin care product that has a greater affinity for ROS than similar products known to date. It is another object of the present invention to provide a method for manufacturing a skin care product that does not use organic solvents and does not use high temperatures.
It is a primary object of the present invention to provide a skin care product and a method of manufacturing the same that is highly reliable, relatively easy to implement and cost competitive.
This task, as well as these and other objects, which will become apparent later, are achieved by lipid particles, wherein the particles each comprise:
- (a) a substrate comprising:
(i) From greater than or equal to 20 wt% to less than or equal to 60 wt% of a lipid component based on the total weight of the lipid particle, the lipid component characterized by a melting temperature of greater than or equal to 40 ℃ to less than or equal to 55 ℃;
(ii) From greater than or equal to 20 wt% to less than or equal to 30 wt% of one or more unsaturated fatty acids, based on the total weight of the lipid particle;
(iii) From greater than or equal to 10 wt% to less than or equal to 12 wt% of one or more excipients selected from the group consisting of surfactants, suspending agents, humectants, and mixtures thereof, based on the total weight of the lipid particle;
and (b) at least one antioxidant incorporated into the matrix.
The aim and objects of the invention are also achieved by a method for preparing a lipid particle according to the invention, comprising the steps of:
(i) Melting the lipid component;
(ii) Dispersing one or more unsaturated fatty acids in the fusogenic lipid component of step (i);
(iii) Dispersing in water preheated to a temperature of greater than or equal to 40 ℃ to less than or equal to 50 ℃ the following:
-at least one antioxidant; and
-one or more excipients;
(iv) Adding the dispersion obtained in step (ii) to the aqueous dispersion obtained in step (iii) under stirring to obtain an emulsion;
(v) Cooling the emulsion obtained in step (iv) to a temperature of greater than or equal to 5 ℃ to less than or equal to 15 ℃ to obtain an emulsion consisting of lipid particles in the aqueous phase.
Furthermore, the task and object of the present invention are also achieved by lipid particles for the topical treatment of a condition associated with ROS ("reactive oxygen species") accumulation in the skin of a patient, wherein the lipid particles each comprise:
(a) A substrate, the substrate comprising:
(i) Lipid component;
(ii) One or more unsaturated fatty acids;
(iii) One or more excipients selected from the group consisting of surfactants, suspending agents, humectants, and mixtures thereof;
and
(b) At least one antioxidant incorporated into the matrix.
The aim and objects of the present invention are also achieved by a skin care product comprising the lipid particle according to the present invention.
Finally, the objects and purposes of the present invention are also achieved by a lipid particle according to the present invention or a skin care product according to the present invention for the topical treatment of a condition associated with ROS accumulation in the skin of a patient.
Other features and advantages of the present invention will become apparent from the following detailed description.
Detailed Description
In a first aspect, the present invention relates to lipid particles, wherein the particles each comprise a matrix and at least one antioxidant incorporated therein.
The matrix of the lipid particle of the invention comprises from greater than or equal to 20 wt% to less than or equal to 60 wt% of a lipid component having a melting temperature of from greater than or equal to 40 ℃ to less than or equal to 55 ℃, based on the total weight of the lipid particle.
Advantageously, the aforementioned melting temperature is closer to the temperature of the skin (37 ℃) than the melting temperature of other waxes used to produce lipid particles, such as microcrystalline wax, carnauba wax, beeswax, which have melting temperatures higher than 65 ℃.
In a preferred embodiment, the lipid component is a mixture of at least two of the following: mimosa wax (acacia decurrens)), jojoba seed wax, sunflower seed wax, polyglycerol, pentaerythritol distearate and transesterification products of polyglycerol with at least one wax selected from jojoba wax, mimosa wax and sunflower seed wax.
Furthermore, the matrix of the lipid particle according to the invention comprises (ii) from greater than or equal to 20 wt% to less than or equal to 30 wt% based on the total weight of the lipid particle of one or more unsaturated or preferably polyunsaturated fatty acids, which provide the lipid particle of the invention with the property of interacting with ROS by having a high affinity for ROS, thereby releasing the active ingredient in a targeted manner. Thus, the lipid particles of the present invention have a matrix characterized by a high affinity for ROS.
In the present specification, the term "affinity" means the tendency of active ingredients or lipid particles comprising them to have interactions with ROS.
As described above, ROS affinity is measured by iodine index.
As mentioned above, lipid particles commonly used today have an oxidation stable matrix.
In the present specification, the expression "stable matrix" means a matrix stable to oxidation, and in the case of a lipid matrix, this means an iodine index of less than 60g iodine per 100g, wherein the iodine index is measured according to ASTM D1959-97.
In a preferred embodiment, the matrix of lipid particles according to the invention has an iodine index higher than or equal to 60g iodine per 100g, wherein the iodine index is measured according to ASTM D1959-97.
The matrix of the particles of the present invention comprises one or more unsaturated fatty acids, preferably selected from the group consisting of C16-C24 unsaturated fatty acids and mixtures thereof. In a preferred embodiment, the one or more unsaturated fatty acids are selected from the group consisting of linoleic acid, linolenic acid, alpha-linolenic acid, oleic acid, and mixtures thereof.
Preferably, the one or more unsaturated fatty acids of the matrix comprise at least 60 wt% polyunsaturated fatty acids based on the total weight of unsaturated fatty acids.
The lipid particle of the present invention comprises at least one antioxidant incorporated into a matrix.
Preferably, the at least one antioxidant is selected from BHT (butylhydroxytoluene), vitamin E, vitamin C, BHA (butylhydroxyanisole), polyphenols, carotenoids, superoxide dismutase and bisulphites.
In the context of the present specification, the term "vitamin C" refers to ascorbic acid and its derivatives, such as, for example, sodium ascorbyl phosphate, ascorbyl tetraisopalmitate, 3-O-cetyl ascorbic acid and ascorbyl glucoside.
Thus, a matrix enriched in lipid particles of unsaturated and polyunsaturated fatty acids that provide high affinity for ROS allows to selectively deliver antioxidants incorporated therein and act as "scavengers" in ROS-enriched skin areas, allowing to neutralize them.
Preferably, in the lipid particle of the present invention, the content of the at least one antioxidant is comprised between 5% and 20% by weight based on the total weight of the lipid particle.
The matrix of the lipid particle according to the present invention further comprises (iii) from greater than or equal to 10 wt% to less than or equal to 12 wt% of one or more excipients selected from the group consisting of surfactants, suspending agents, wetting agents and mixtures thereof, based on the total weight of the lipid particle.
Preferably, the at least one excipient is selected from polysorbates, polyacrylates, xanthan gums, alkyl glucosides and glycols.
In addition, the lipid particle of the present invention may further comprise one or more active ingredients incorporated into the matrix, wherein the one or more active ingredients are selected from vitamins, peptides, minerals, growth factors, and natural extracts.
The active ingredients have the functions of restoring physiological balance, repairing and stimulating the mechanism of self-repair of skin damaged by excessive concentration of ROS.
The term "active ingredient" in this specification refers to a substance that is biologically active or affects the appearance and condition of the skin.
In the present specification, the expression "bioactive" means that such a substance has an effect on biological tissues (in this case skin), or has a cosmetic effect on them.
In a second aspect, the present invention relates to a method for preparing a lipid particle according to the present invention, the method comprising the steps of:
(i) Melting the lipid component;
(ii) Dispersing the one or more unsaturated fatty acids in the fusogenic lipid component of step (i);
(iii) Dispersing in water preheated to a temperature of greater than or equal to 40 ℃ to less than or equal to 50 ℃ the following:
-said at least one antioxidant; and
-said one or more excipients;
(iv) Adding the dispersion obtained in step (ii) to the aqueous dispersion obtained in step (iii) under stirring to obtain an emulsion;
(v) Cooling the emulsion obtained in step (iv) to a temperature of greater than or equal to 5 ℃ to less than or equal to 15 ℃ to obtain an emulsion consisting of lipid particles in the aqueous phase.
In step (iv), the stirring is preferably carried out at a constant speed of 1000 to 8000 revolutions per minute.
Preferably, prior to step (v), the emulsion obtained in step (iv) is sieved through a mesh having pores ranging in size from greater than or equal to 0.1 μm to less than or equal to 50 μm, obtaining an emulsion consisting of lipid particles in the aqueous phase ranging in size from greater than or equal to 0.1 μm to less than or equal to 50 μm. After cooling in step (v), the emulsion may then be dried in vacuo at a temperature below 40 ℃ and/or stabilized by adding preservatives like for example sodium benzoate, potassium sorbate, isothiazolinones, phenoxyethanol, formaldehyde scavengers, chelators.
In a preferred embodiment of the method according to the invention, the lipid component is a mixture of at least two of the following: transesterification products of mimosa wax (vitex negundo), jojoba seed wax, sunflower seed wax, polyglycerol, pentaerythritol distearate, polyglycerol 3 with at least one wax selected from the group consisting of jojoba wax, mimosa wax and sunflower seed wax;
the choice of the above wax mixture advantageously allows the preparation of particles by a process that does not require high temperatures or organic solvents.
In a preferred embodiment, the process according to the invention does not comprise the use of organic solvents.
The lipid particles of the invention obtained as described above can then be incorporated into skin care products selected from the group consisting of lotions, creams and lotions, and they are mixed with said skin care products at a temperature lower than or equal to 40 ℃ and at a speed of 100-200 revolutions per minute until completely homogenized.
The invention therefore also relates to a skin care product comprising the lipid particle according to the invention. The product, preferably selected from the group consisting of a concentrate, a cream and a lotion, is optionally packaged in an airtight container, protected from ROS formation inside it.
The present invention also relates to the above lipid particles and the above skin care products for the topical treatment of conditions associated with ROS accumulation in the skin of a patient.
Skin conditions associated with ROS accumulation include premature aging, loss of elasticity, loss of hydration, hyperpigmentation, skin discoloration, acne, and imbalance in physiological balance.
The invention also relates to lipid particles for use in the topical treatment of a condition associated with ROS accumulation in the skin of a patient, wherein each lipid particle comprises:
(a) A substrate, the substrate comprising:
(i) Lipid component;
(ii) One or more unsaturated fatty acids;
(iii) One or more excipients selected from the group consisting of surfactants, suspending agents, humectants, and mixtures thereof;
and
(b) At least an antioxidant, which is incorporated into the matrix.
The present invention of course also relates to a method of treating a condition associated with ROS accumulation in the skin of a patient by administering the above lipid particle or skin care product to the patient.
The invention will now be described with reference to the following non-limiting examples.
Example 1: preparation of lipid particles according to the invention.
To prepare 1kg of a composition comprising the lipid particle of the present invention for use as an intermediate in the preparation of cosmetics, the procedure is as follows:
(i) 90g of blend of jojoba wax, mimosa wax and sunflower seed waxMB, ACTICIRE-GATTE FOSSE) and 30g of natural polyunsaturated fatty acids obtained from safflower oil (Vitamin F for, CLR Berlin) were melted in a beaker under magnetic stirring at 200rpm by heating at a temperature of 55℃for 10 minutes until the phases were completely melted;
(ii) Adding 30g of a mixture of natural polyunsaturated fatty acids obtained from safflower oil (vitaminf for, CLR Berlin) to the molten lipid mixture obtained in step (i) while magnetically stirring at 200rpm, while maintaining the temperature at 55 ℃, until a homogeneous "fat" molten mixture is obtained;
(iii) An aqueous dispersion was prepared by adding 758ml of water heated to 45 ℃ followed by stirring (500 rpm,10 min):
-20g of decyl glucoside, the concentration of which is chosen,
100g of sodium ascorbyl phosphate,
-2g of hyaluronic acid;
(iv) Adding the aqueous dispersion prepared in point (iii) to the fat mixture prepared in point (ii) by maintaining the temperature at 48 ℃ and stirring at 3500rpm for 10 minutes to obtain an emulsion of lipid particles in the aqueous phase;
(iv-a) sieving the emulsion obtained in step (iv) through a mesh having pores with a diameter of 25 μm to obtain an emulsion of lipid particles with a diameter of at most 25 μm in an aqueous phase;
(v) Cooling the emulsion obtained in step (iv-a) to 10 ℃ by means of a water bath to accelerate the solidification of the lipid fraction;
indeed, it has been found that the present invention achieves the intended aim and objects by producing lipid particles and skin care products which are characterized by a high affinity for ROS and are capable of delivering active ingredients incorporated in the matrix of the lipid particles to areas with ROS, and in particular those areas with a higher ROS concentration.
Skin care products incorporating lipid particles according to the invention advantageously have a greater affinity for ROS than similar products on the market today.
Furthermore, the present invention perfects a method for manufacturing a skin care product that does not include the use of organic solvents and the use of high temperatures.
The invention thus conceived is susceptible of numerous modifications and variations, all of which are within the scope of the inventive concept; furthermore, all the details may be replaced by other technically equivalent elements.
In fact, the materials employed may be any according to the requirements and the state of the art, provided that they are compatible with the specific use, as well as the contingent shapes and dimensions.
Claims (14)
1. Lipid particles, wherein each particle comprises:
- (a) a substrate comprising:
(i) From greater than or equal to 20 wt% to less than or equal to 60 wt% of a lipid component, based on the total weight of the lipid particle, the lipid component having a melting temperature of greater than or equal to 40 ℃ to less than or equal to 55 ℃;
(ii) From greater than or equal to 20 wt% to less than or equal to 30 wt% of one or more unsaturated fatty acids, based on the total weight of the lipid particle;
(iii) From greater than or equal to 10% to less than or equal to 12% by total weight of the lipid particle of one or more excipients selected from the group consisting of surfactants, suspending agents, humectants, and mixtures thereof;
and (b) at least one antioxidant incorporated into the matrix.
2. The lipid particle of claim 1, wherein the lipid component is a mixture of at least two of: transesterification products of mimosa wax (vitex virginiana), jojoba seed wax, sunflower seed wax, polyglycerol, pentaerythritol distearate and polyglycerol with at least one wax selected from the group consisting of jojoba wax, mimosa wax and sunflower seed wax.
3. The lipid particle of claim 1 or 2, wherein the matrix has an iodine index of greater than or equal to 60g iodine per 100g, wherein the iodine index is measured according to ASTM D1959-97.
4. The lipid particle of one or more of the preceding claims, wherein the one or more unsaturated fatty acids comprise at least 60 wt.% polyunsaturated fatty acids based on the total weight of the unsaturated fatty acids.
5. Lipid particle according to one or more of the preceding claims, wherein the content of the at least one antioxidant is from greater than or equal to 5 wt% to less than or equal to 20 wt%, based on the total weight of the lipid particle.
6. Lipid particle according to one or more of the preceding claims, wherein the one or more unsaturated fatty acids are selected from the group consisting of C16-C24 fatty acids and mixtures thereof.
7. Lipid particle according to one or more of the preceding claims, wherein the at least one excipient is selected from polysorbates, polyacrylates, xanthan gums, alkyl glucosides and glycols.
8. Lipid particle according to one or more of the preceding claims, wherein the at least one antioxidant is selected from BHT (butylhydroxytoluene), vitamin E, vitamin C, BHA (butylhydroxyanisole), polyphenols, carotenoids, superoxide dismutase and bisulphite.
9. Lipid particle according to one or more of the preceding claims, further comprising one or more active ingredients incorporated into the matrix, wherein the one or more active ingredients are selected from vitamins, peptides, minerals, growth factors and natural extracts.
10. A process for preparing a lipid particle according to the invention, the process comprising the steps of:
(i) Melting the lipid component;
(ii) Dispersing one or more unsaturated fatty acids in the fusogenic lipid component of step (i);
(iii) Dispersing in water preheated to a temperature of greater than or equal to 40 ℃ to less than or equal to 50 ℃ the following:
-at least one antioxidant: and
-one or more excipients:
(iv) Adding the dispersion obtained in step (ii) to the aqueous dispersion obtained in step (iii) with stirring to obtain an emulsion:
(v) Cooling the emulsion obtained in step (iv) to a temperature of greater than or equal to 5 ℃ to less than or equal to 15 ℃ to obtain an emulsion consisting of lipid particles in the aqueous phase.
11. The method of claim 10, wherein the method does not include the use of an organic solvent.
12. Lipid particles for use in the topical treatment of a condition associated with ROS ("reactive oxygen species") accumulation in the skin of a patient, wherein each lipid particle comprises:
(a) A substrate, the substrate comprising:
(i) Lipid component;
(ii) One or more unsaturated fatty acids:
(iii) One or more excipients selected from the group consisting of surfactants, suspending agents, humectants, and mixtures thereof;
and
(b) At least one antioxidant incorporated into the matrix.
13. Skin care product comprising the lipid particle according to one or more of claims 1-9.
14. Lipid particles according to one or more of claims 1-9 or a skin care product according to claim 13 for use in the topical treatment of a condition associated with ROS accumulation in the skin of a patient.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102021000014330 | 2021-06-01 | ||
IT102021000014330A IT202100014330A1 (en) | 2021-06-01 | 2021-06-01 | Skin care product and process for making it. |
PCT/US2022/031333 WO2022256256A1 (en) | 2021-06-01 | 2022-05-27 | Skin care product and procedure for its production |
Publications (1)
Publication Number | Publication Date |
---|---|
CN117412744A true CN117412744A (en) | 2024-01-16 |
Family
ID=77317368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202280039737.7A Pending CN117412744A (en) | 2021-06-01 | 2022-05-27 | Skin care product and process for its production |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP4346798A1 (en) |
JP (1) | JP2024520341A (en) |
KR (1) | KR20240017376A (en) |
CN (1) | CN117412744A (en) |
AU (1) | AU2022284776A1 (en) |
CA (1) | CA3218918A1 (en) |
IL (1) | IL308723A (en) |
IT (1) | IT202100014330A1 (en) |
WO (1) | WO2022256256A1 (en) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU85130A1 (en) * | 1983-12-12 | 1985-09-12 | Oreal | AQUEOUS COSMETIC OR ANHYDROUS COMPOSITION CONTAINING A FATTY PHASE BASED ON SHEA OIL |
DE10253042A1 (en) * | 2002-11-14 | 2004-06-03 | Wacker-Chemie Gmbh | Cosmetic preparation containing a complex of cyclodextrin and vitamin F. |
US9056050B2 (en) * | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
EP3154529B1 (en) * | 2014-06-10 | 2020-07-08 | Capsugel Belgium NV | Orally disintegrating tablet containing solid lipid particles and methods for their preparation and use |
JP6602834B2 (en) * | 2014-06-30 | 2019-11-06 | ターベダ セラピューティクス インコーポレイテッド | Targeted conjugates and particles and formulations thereof |
CN105816423B (en) * | 2016-03-16 | 2018-07-20 | 福建天泰医药科技有限公司 | edaravone dosage form |
US20190201350A1 (en) * | 2016-08-15 | 2019-07-04 | Corr-Jensen Inc. | Time release of fat-soluble actives |
IT201900022764A1 (en) * | 2019-12-03 | 2021-06-03 | Skb Llc | SKIN CARE PRODUCT AND PROCEDURE FOR ITS REALIZATION |
-
2021
- 2021-06-01 IT IT102021000014330A patent/IT202100014330A1/en unknown
-
2022
- 2022-05-27 JP JP2023571671A patent/JP2024520341A/en active Pending
- 2022-05-27 AU AU2022284776A patent/AU2022284776A1/en active Pending
- 2022-05-27 CN CN202280039737.7A patent/CN117412744A/en active Pending
- 2022-05-27 CA CA3218918A patent/CA3218918A1/en active Pending
- 2022-05-27 IL IL308723A patent/IL308723A/en unknown
- 2022-05-27 WO PCT/US2022/031333 patent/WO2022256256A1/en active Application Filing
- 2022-05-27 EP EP22816683.1A patent/EP4346798A1/en active Pending
- 2022-05-27 KR KR1020237045488A patent/KR20240017376A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL308723A (en) | 2024-01-01 |
EP4346798A1 (en) | 2024-04-10 |
AU2022284776A1 (en) | 2023-11-09 |
IT202100014330A1 (en) | 2022-12-01 |
WO2022256256A1 (en) | 2022-12-08 |
CA3218918A1 (en) | 2022-12-08 |
JP2024520341A (en) | 2024-05-24 |
KR20240017376A (en) | 2024-02-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Yang et al. | Encapsulating plant ingredients for dermocosmetic application: An updated review of delivery systems and characterization techniques | |
Nanjwade et al. | Formulation and characterization of nanostructured lipid carrier of ubiquinone (Coenzyme Q10) | |
KR20160093065A (en) | Lipid microcapsules preferably comprising a lipophilic active substance and composition containing same, method for the production thereof, and use of same in dermatology and in cosmetics | |
US20080219939A1 (en) | Sunblock formulations | |
KR20140011550A (en) | Oil capsule composition for an cosmetic | |
KR100781604B1 (en) | Method of stabilization of active ingredients that have low solubility, using hollow type multi-layered microcapsule made of hydrophobic polymer/polyhydric alcohols and preparation method thereof, and cosmetic composition containing the microcapsules | |
Nitthikan et al. | Improvement of stability and transdermal delivery of bioactive compounds in green robusta coffee beans extract loaded nanostructured lipid carriers | |
D’Souza et al. | Nanostructured lipid carriers (NLCs) for drug delivery: Role of liquid lipid (oil) | |
KR101592307B1 (en) | Non-aqueous oil balm type cosmetics composition stabilizing the oil soluble active ingredients and method for producing the same | |
US20220287929A1 (en) | Skin care product and method for its production | |
KR101484836B1 (en) | Cosmetic capsule with oil-soluble effective ingredients and cosmetic composition comprising the capsule | |
KR101442799B1 (en) | nano suspension-some cosmetic composition in oil containing stabilized L-ascorbic acid or its derivatives, and method for manufacturing the same | |
KR20160106268A (en) | Microcapsules Containing Dedifferentiated Plant Protoplast Complex With Active Material Insertion and Cosmetic Composition Comprising the Microcapsules | |
CN117412744A (en) | Skin care product and process for its production | |
EP1408924A1 (en) | Stabilized ascorbic acid, composition, and method of use | |
CN117379337A (en) | Retinol derivative supermolecule microcapsule, preparation method and application thereof | |
Chien et al. | Drug delivery approaches to improve the efficiency of phytoderivatives against UV induced damage-A review | |
JP6930846B2 (en) | Cosmetics or topical skin agents | |
KR102246331B1 (en) | Biodegradable nano-particle containing pinus bungeana extract and preparation method thereof | |
JP2018172291A (en) | Cosmetic or skin external preparation | |
JP7125268B2 (en) | Cosmetics and external skin preparations | |
JP6930848B2 (en) | Cosmetics or topical skin agents | |
Sharma et al. | Development of NLC-based Sunscreen Gel of Lutein and its in-vitro and ex-vivo Characterisation | |
Tripathi et al. | Nanoformulations of quercetin: a potential phytochemical for the treatment of uv radiation induced skin damages | |
RO131547A2 (en) | Plant squalene-based nanocarriers capable to co-encapsulate hydrophilic and lipophilic medicaments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication |