CN117338608A - Sponge microneedle whitening and freckle removing cream and preparation method thereof - Google Patents
Sponge microneedle whitening and freckle removing cream and preparation method thereof Download PDFInfo
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- CN117338608A CN117338608A CN202311486831.XA CN202311486831A CN117338608A CN 117338608 A CN117338608 A CN 117338608A CN 202311486831 A CN202311486831 A CN 202311486831A CN 117338608 A CN117338608 A CN 117338608A
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- percent
- sponge
- microneedle
- whitening
- freckle removing
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 51
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 43
- 239000006071 cream Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims abstract description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Natural products CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940089468 hydroxyethylpiperazine ethane sulfonic acid Drugs 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 12
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims abstract description 11
- 229960000401 tranexamic acid Drugs 0.000 claims abstract description 11
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical group CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 claims abstract description 10
- 229920001184 polypeptide Polymers 0.000 claims abstract description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 10
- BJRNKVDFDLYUGJ-ZIQFBCGOSA-N alpha-Arbutin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-ZIQFBCGOSA-N 0.000 claims abstract description 9
- 229940033280 alpha-arbutin Drugs 0.000 claims abstract description 9
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims abstract description 7
- 108010087806 Carnosine Proteins 0.000 claims abstract description 7
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims abstract description 7
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims abstract description 7
- 229940044199 carnosine Drugs 0.000 claims abstract description 7
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 13
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000000341 volatile oil Substances 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 9
- 235000010323 ascorbic acid Nutrition 0.000 claims description 7
- 239000011668 ascorbic acid Substances 0.000 claims description 7
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- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
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- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 5
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 5
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 5
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 5
- 229940036350 bisabolol Drugs 0.000 claims description 5
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 5
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 239000003906 humectant Substances 0.000 claims description 5
- 229940057910 shea butter Drugs 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
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- 235000010254 Jasminum officinale Nutrition 0.000 claims description 3
- 240000005385 Jasminum sambac Species 0.000 claims description 3
- 244000178870 Lavandula angustifolia Species 0.000 claims description 3
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 3
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- 235000018219 lavender Nutrition 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 46
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 28
- 230000000694 effects Effects 0.000 abstract description 14
- 239000013543 active substance Substances 0.000 abstract description 6
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- 238000000354 decomposition reaction Methods 0.000 abstract description 4
- 210000004207 dermis Anatomy 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 abstract description 3
- 238000005282 brightening Methods 0.000 abstract description 2
- 238000005562 fading Methods 0.000 abstract description 2
- 229940035423 ethyl ether Drugs 0.000 abstract 1
- 239000000047 product Substances 0.000 description 24
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 10
- 210000002615 epidermis Anatomy 0.000 description 9
- 210000000434 stratum corneum Anatomy 0.000 description 8
- 229960003966 nicotinamide Drugs 0.000 description 7
- 235000005152 nicotinamide Nutrition 0.000 description 7
- 239000011570 nicotinamide Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
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- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229930003268 Vitamin C Natural products 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 235000019154 vitamin C Nutrition 0.000 description 4
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
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- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
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- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to the technical field of daily chemicals, and aims to provide a sponge microneedle whitening and freckle removing cream and a preparation method thereof. The preparation raw materials of the invention comprise: nicotinamide, sponge micropin, tranexamic acid, alpha-arbutin, ascorbyl polypeptide, vitamin C ethyl ether, carnosine, hydroxyethyl piperazine ethane sulfonic acid, auxiliary components, water and the like. The skin is pierced by the sponge micropin, so that the active substances can quickly permeate into the dermis layer of the skin, the decomposition of melanin is accelerated, the pigmentation is reduced, and the effects of brightening skin color and fading spots are achieved.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to a sponge microneedle whitening and freckle removing skin care product and a preparation method thereof.
Background
The application of the functional skin care product additive in the skin care product can inject new vitality into the development of the skin care product, but the problem of the permeability of active components on the skin in the research and development process often greatly limits the development of the functional skin care product.
The skin care products of the whitening and freckle-removing products on the market are relatively more, but the effect is more general, most of the skin care products can only permeate into the stratum corneum, and the active ingredients of the whitening and freckle-removing products can not permeate below the stratum corneum, so that the decomposition of melanin of the skin barrier after the skin care products are used and the reduction of pigmentation is slow or even not ideal.
Disclosure of Invention
The invention aims to solve the confusion of skin care, and discloses a sponge microneedle whitening and freckle removing cream, which can enable active substances to quickly permeate into skin dermis layers through the penetration of epidermis by the sponge microneedle, accelerate the decomposition of melanin and reduce pigment deposition, so as to achieve the effects of brightening skin colors and fading spots.
In order to achieve the above purpose, the invention adopts the following technical scheme:
the sponge microneedle whitening and freckle removing cream comprises the following raw materials in percentage by mass:
0.5 to 3 percent of nicotinamide,
1% -5% of sponge microneedle,
0.5 to 2 percent of tranexamic acid,
0.5 to 1 percent of alpha-arbutin,
0.5% -1% of ascorbic acid polypeptide,
0.5 to 2 percent of vitamin C ethyl ether,
0.1 to 0.5 percent of carnosine,
0.5% -2% of hydroxyethyl piperazine ethane sulfonic acid,
0.5 to 1 percent of shea butter,
0.1 to 0.5 percent of vitamin E,
0.1 to 0.5 percent of bisabolol,
1 to 3 percent of butanediol,
0.01 to 0.1 percent of sodium hyaluronate,
2% -10% of auxiliary components,
The balance of water.
The main structure of the sponge microneedle is silica-formed spicule, the length is 200-250 μm, the width is 10-20 μm, when in use, the spicule can enter the skin epidermis layer by slight massage, a micro-channel is formed in the skin epidermis layer, and the micro-circulation of the epidermis skin is started, so that the active ingredient can penetrate through the stratum corneum. The sponge microneedle has the functions of continuously stimulating cells and promoting cell differentiation, effectively promoting natural shedding of aged keratinocytes, achieving natural, safe and effective physical skin replacement, and facilitating transdermal absorption and helping active substances to enter the epidermis layer of the skin. Meanwhile, silicon element contained in the sponge microneedle can promote synthesis of collagen; in the process, the sponge microneedles also bring other nutrient substances in the composition into the epidermis layer of the skin, promote the permeation and absorption of the nutrient components and help the composition to play a better role.
The nicotinamide is obviously different from the traditional whitening component, and can reduce the generation of skin melanin to achieve skin whitening by inhibiting tyrosinase activity, but acts on the generated melanin, reduces the transfer of the melanin to surface cells, accelerates metabolism, promotes the shedding of melanocyte, promotes the synthesis of epidermal layer protein, and improves the skin texture.
Tranexamic acid is a protease inhibitor, and can inhibit the catalytic action of protease on peptide bond hydrolysis, so that the activity of enzymes such as originating protease and the like can be prevented, the disorder of the functions of epidermal cells at black spots can be inhibited, the melanin-enhancing factor group can be inhibited, and the melanin generation path formed by ultraviolet irradiation can be thoroughly interrupted, namely, the black spots can not be thickened, enlarged and increased, and the pigmentation of skin can be effectively prevented and improved.
Vitamin C is approved by high-efficiency freckle removing and whitening effects and high safety, but is extremely easy to oxidize, difficult to be truly absorbed by skin and low in skin availability. Compared with vitamin C, the vitamin C ethyl ether and the ascorbic acid polypeptide are used as vitamin C derivatives, penetrate through the stratum corneum into the dermis easily, are decomposed by biological enzymes after entering the skin to play a role of vitamin C, and improve the availability of the vitamin C, so that better freckle removing and whitening effects are achieved. The biotin C ethyl ether directly participates in synthesis of collagen to restore skin cell activity after entering the dermis layer, so that the collagen is increased, and the skin becomes full and elastic, and is fine and smooth.
The alpha-arbutin is a natural active substance derived from green plants, integrates the three components of green plants, safety and reliability and high-efficiency decolorization, can quickly permeate into skin, can effectively inhibit the activity of tyrosinase in the skin while not affecting the proliferation concentration of cells, blocks the formation of melanin, and accelerates the decomposition and excretion of the melanin by directly combining the alpha-arbutin with the tyrosinase, thereby reducing the pigmentation of the skin, removing color spots and freckles, and having no toxic, irritant, sensitization and other side effects on melanocytes, and also has the functions of sterilization and anti-inflammation.
The hydroxyethyl piperazine ethane sulfonic acid has the effect of exfoliating, can assist in removing aged cutin on the surface of skin, and other active ingredients are easier to permeate into the skin after the keratinized layer is softened or removed by the hydroxyethyl piperazine ethane sulfonic acid; in addition, the hydroxyethyl piperazine ethane sulfonic acid can also receive ultraviolet rays, so that the irritation of the ultraviolet rays to pigment cells is reduced, and the formation of melanin in the skin can be reduced.
Optionally, the material comprises the following raw materials in percentage by mass:
2% -3% of nicotinamide,
2% -4% of sponge microneedle,
1% -2% of tranexamic acid,
0.8 to 1 percent of alpha-arbutin,
0.8% -1% of ascorbic acid polypeptide,
1 to 1.5 percent of vitamin C ethyl ether,
0.2 to 0.4 percent of carnosine,
1 to 1.5 percent of hydroxyethyl piperazine ethane sulfonic acid,
0.8 to 1 percent of shea butter,
0.3 to 0.5 percent of vitamin E,
0.3 to 0.5 percent of bisabolol,
1 to 3 percent of butanediol,
0.03 to 0.07 percent of sodium hyaluronate,
5% -10% of auxiliary components,
The balance of water.
Optionally, the sponge microneedle is a siliceous sponge bone needle, and has a length of 200-250 μm and a width of 10-20 μm.
Optionally, the auxiliary components include: at least one of surfactant, humectant and essential oil.
Optionally, the essential oil is a mixture of lavender essential oil and jasmine essential oil.
The invention further aims to provide a preparation method of the sponge microneedle whitening and freckle removing cream.
Optionally, the preparation method of the sponge microneedle whitening and freckle removing cream comprises the following steps:
(1) Weighing the raw materials according to a proportion;
(2) Adding the humectant, the surfactant and the water into a water phase pot, uniformly mixing, and heating to 75 ℃ to obtain a water phase material;
(3) Adding the rest components into an oil phase pot, heating to 60 ℃, and stirring and mixing uniformly to obtain an oil phase material;
(4) Pumping the water phase material into an emulsifying pot, stirring and homogenizing, pumping the oil phase material, and homogenizing at 45 ℃ to obtain the sponge needle whitening and freckle removing cream.
Optionally, the homogenizing time in the step (4) is 15min.
The invention has the beneficial effects that:
(1) The sponge microneedle whitening and freckle removing cream contains the sponge microneedle, the sponge microneedle can penetrate into the stratum corneum and the epidermis layer, the aging keratinocytes can be effectively promoted to fall off, a tiny channel is formed on the stratum corneum, the cellular metabolism is promoted, the generation of collagen is stimulated, and the transdermal absorption of whitening and freckle removing components can be promoted.
(2) The whitening and freckle-removing component disclosed by the invention completely covers various whitening passages, firstly, alpha-arbutin, tranexamic acid and carnosine are used for inhibiting the activity of the aminopeptidase, and the activation of melanocytes is prevented; secondly, reducing a melanin intermediate dopa by using ascorbic acid polypeptide and vitamin C ethyl ether to block the oxidation process of melanin; further, nicotinamide prevents the produced melanin from being transported to the epidermal keratinocytes; finally, the metabolism of the keratinocytes is accelerated by the hydroxyethyl piperazine ethane sulfonic acid, so that melanin in the keratinocytes is accelerated to fall off. Through the preferable combination of the active substances, the sponge microneedle whitening and freckle removing cream has the effect of high-efficiency whitening and freckle removing.
(3) The sponge microneedle whitening and freckle removing cream completely accords with various indexes in the 'cosmetic health Specification' issued by the nation, and does not contain any toxic substances.
Detailed Description
The present invention will be further described with reference to examples, but the scope of the invention as claimed is not limited to the scope expressed by the examples.
Example 1
The sponge microneedle whitening and freckle removing cream comprises the following raw materials in percentage by mass:
0.5% nicotinamide,
1% of sponge microneedle,
0.5 part of tranexamic acid,
0.5% of alpha-arbutin,
0.5% of ascorbyl polypeptide,
0.5% of vitamin C ethyl ether,
0.1% carnosine,
0.5% of hydroxyethyl piperazine ethane sulfonic acid,
0.5 percent of shea butter,
0.1% of vitamin E,
0.1 percent of bisabolol,
1% of butanediol,
0.01% of sodium hyaluronate,
Auxiliary components 2%,
The balance of water.
Wherein the auxiliary components comprise 0.6% of glycerin humectant, 1.0% of modified dodecyl sugar amide surfactant, 0.2% of lavender essential oil and 0.2% of jasmine essential oil.
The skin care product is prepared by the following steps:
(1) Weighing the raw materials according to a proportion;
(2) Adding glycerin, modified dodecyl sugar amide and water into a water phase pot, uniformly mixing, and heating to 75 ℃ to obtain a water phase material;
(3) Adding the rest components into an oil phase pot, heating to 60 ℃, and stirring and mixing uniformly to obtain an oil phase material;
(4) Pumping the water phase material into an emulsifying pot, stirring and homogenizing, pumping the oil phase material into the emulsifying pot, and homogenizing for 15min at the temperature of 45 ℃ to obtain the sponge needle whitening and freckle removing cream.
The using method comprises the following steps: after cleaning the skin, a proper amount of the skin care cream is smeared on the face, and is gently massaged until the skin care cream is absorbed.
Examples 2 to 5
The preparation method of experimental example 1 was repeated according to the contents specified in table 1 below, and a skin care product for whitening and removing spots with a sponge microneedle was prepared respectively.
Table 1 raw materials formulation table (%)
Comparative examples 1 to 5
TABLE 2 raw materials formulation table (%)
Comparative example 1 differs from example 3 in that the sponge microneedle was replaced with an equivalent amount of nicotinamide.
Comparative example 2 differs from example 3 in that the nicotinamide is replaced by an equivalent amount of tranexamic acid.
Comparative example 3 differs from example 3 in that the equivalent amount of nicotinamide was used instead of tranexamic acid.
Comparative example 4 differs from example 3 in that the ascorbyl polypeptide and vitamin C ethyl ether are replaced with an equivalent amount of nicotinamide.
Comparative example 5 differs from example 3 in that the same amount of nicotinamide was used instead of hydroxyethylpiperazine ethane sulfonic acid.
The safety of the sponge microneedle whitening and freckle removing skin care products prepared in examples 1 to 5 and comparative examples 1 to 5 was evaluated, and the safety was specifically as follows:
(1) Microbiological detection: according to the determination method of the total number of bacterial colonies, the coliform faecalis, the staphylococcus aureus, the pseudomonas, the mould and the saccharomycetes in the sanitary Specification of skin care products (2007 edition), the microbial detection of the sponge microneedle whitening and freckle removing skin care product provided by the invention is all qualified.
(2) And (3) sanitary chemical detection: according to the method for measuring total mercury, total arsenic and total lead in skin care product sanitary Specification (2007 edition), the metal elements of the sponge microneedle whitening and freckle removing skin care product provided by the invention are detected to be all qualified.
(3) Irritation detection: according to the basic principle, requirement and method of animal skin irritation or corrosiveness test specified in skin care product health Specification (2007 edition), the sponge microneedle whitening and freckle removing skin care products of the embodiments 1-5 are tested, and the average value of skin irritation integral is measured to be less than 0.2, which indicates no irritation.
(4) White and humidity test:
test object: 100 dry subjects with dark yellow faces and obvious pigmentation were selected, 100 dry subjects with ages of 30-40 years, and 10 persons in each group were divided into 10 groups, and the humidity and whiteness of the faces of the subjects in each group were not significantly different before use.
The using method comprises the following steps: each group was applied to the face after washing the face in the morning and evening for 14 days with the whitening and freckle removing creams prepared in examples 1 to 5 and comparative examples 1 to 5, respectively. During the experiment, the subject was not able to apply any other skin care product at the experimental site.
The testing method comprises the following steps: after washing the face, the white and moist degree of the skin was read using an intelligent detector for the skin of America (imate) M-6602 without applying any cosmetic product, and the average value of the white and moist degree of the face before and after use was calculated for each group of subjects, and the results are shown in Table 3.
TABLE 3 measurement of skin whitening and moisture
As can be seen from table 3, as the content of the sponge microneedle increases in examples 1 to 5, the whitening effect and moisturizing effect of the product are more excellent, and example 5 is the most preferable; the increase is relatively small when the percentage of the sponge microneedles is less than 2%, and relatively large when the percentage of the sponge microneedles is more than 3% and less than 5%; also, since the difference between the embodiment 3 and the embodiment 5 is small, the cost of raw materials is comprehensively considered, and the embodiment 3 is the optimal production formula of the factory.
In comparative example 1, the whitening effect and the moisturizing effect of the product are obviously reduced in the absence of the sponge microneedle component, so that the sponge microneedle can penetrate into the stratum corneum and the epidermis, effectively promote the falling of aged keratinocytes, form tiny channels on the stratum corneum, promote the metabolism of cells, stimulate the generation of collagen, and promote the transdermal absorption of the whitening and freckle removing components.
The whitening and freckle removing components of the sponge microneedle whitening and freckle removing cream disclosed by the invention completely cover various whitening passages, and the sponge microneedle whitening and freckle removing cream disclosed by the invention has the effect of efficiently whitening and freckle removing after being used for 14 days by virtue of the preferable compounding of various active substances, and the whitening and freckle removing components of the sponge amide, the tranexamic acid, the ascorbic acid polypeptide, the vitamin C ethyl ether and the hydroxyethyl piperazine ethane sulfonic acid are reduced in any one of the components of the comparison examples 2-4 and are inferior to those of the examples 3-5.
(5) Self-evaluation test: after the whiteness and humidity tests are completed, sensory scores are carried out on the using effects of each group of subjects, and the score is 0-10, the higher the score is, the better the whiteness and humidity effects of the product are, and the results are shown in Table 4.
TABLE 4 self-evaluation of the results
As can be seen from Table 4, the self-evaluating test level of the whitening and freckle-removing cream prepared in the embodiment 1-5 of the invention is better and far higher than that of the comparative example 1-5, which shows that the sponge microneedle whitening and freckle-removing cream has better whitening efficacy.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above examples, and all technical solutions belonging to the concept of the present invention belong to the protection scope of the present invention. It should be noted that modifications and adaptations to the present invention may occur to one skilled in the art without departing from the principles of the present invention and are intended to be within the scope of the present invention.
Claims (7)
1. The sponge microneedle whitening and freckle removing cream is characterized by comprising the following raw materials in percentage by mass:
0.5 to 3 percent of nicotinamide,
1% -5% of sponge microneedle,
0.5 to 2 percent of tranexamic acid,
0.5 to 1 percent of alpha-arbutin,
0.5% -1% of ascorbic acid polypeptide,
0.5 to 2 percent of vitamin C ethyl ether,
0.1 to 0.5 percent of carnosine,
0.5% -2% of hydroxyethyl piperazine ethane sulfonic acid,
0.5 to 1 percent of shea butter,
0.1 to 0.5 percent of vitamin E,
0.1 to 0.5 percent of bisabolol,
1 to 3 percent of butanediol,
0.01 to 0.1 percent of sodium hyaluronate,
2% -10% of auxiliary components,
The balance of water.
2. The sponge microneedle whitening and freckle removing cream according to claim 1, which is characterized by comprising the following raw materials in percentage by mass:
2% -3% of nicotinamide,
2% -4% of sponge microneedle,
1% -2% of tranexamic acid,
0.8 to 1 percent of alpha-arbutin,
0.8% -1% of ascorbic acid polypeptide,
1 to 1.5 percent of vitamin C ethyl ether,
0.2 to 0.4 percent of carnosine,
1 to 1.5 percent of hydroxyethyl piperazine ethane sulfonic acid,
0.8 to 1 percent of shea butter,
0.3 to 0.5 percent of vitamin E,
0.3 to 0.5 percent of bisabolol,
1 to 3 percent of butanediol,
0.03 to 0.07 percent of sodium hyaluronate,
5% -10% of auxiliary components,
The balance of water.
3. The sponge microneedle whitening and freckle removing cream according to claim 1, wherein the sponge microneedle is a siliceous sponge bone needle, and has a length of 200-250 μm and a width of 10-20 μm.
4. The sponge microneedle whitening and freckle removing cream according to claim 1, wherein the auxiliary components comprise: at least one of surfactant, humectant and essential oil.
5. The sponge microneedle whitening and freckle removing cream according to claim 4, wherein the essential oil is a mixture of lavender essential oil and jasmine essential oil.
6. The method for preparing the sponge microneedle whitening and freckle removing skin care product according to claim 5, which is characterized by comprising the following steps:
(1) Weighing the raw materials according to a proportion;
(2) Adding the humectant, the surfactant and the water into a water phase pot, uniformly mixing, and heating to 75 ℃ to obtain a water phase material;
(3) Adding the rest components into an oil phase pot, heating to 60 ℃, and stirring and mixing uniformly to obtain an oil phase material;
(4) Pumping the water phase material into an emulsifying pot, stirring and homogenizing, pumping the oil phase material, and homogenizing at 45 ℃ to obtain the sponge needle whitening and freckle removing cream.
7. The method for preparing the sponge microneedle whitening and freckle removing cream according to claim 6, wherein the homogenization time in the step (4) is 15min.
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