CN1172654C - Insect repellent sunscreen - Google Patents

Insect repellent sunscreen Download PDF

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Publication number
CN1172654C
CN1172654C CNB97196789XA CN97196789A CN1172654C CN 1172654 C CN1172654 C CN 1172654C CN B97196789X A CNB97196789X A CN B97196789XA CN 97196789 A CN97196789 A CN 97196789A CN 1172654 C CN1172654 C CN 1172654C
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anthelmintic
sunscreen composition
sunscreen
oil
compositions
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CN1226156A (en
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Hj
H·J·尤克
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SC Johnson and Son Inc
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SC Johnson and Son Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Disclosed therein are sunscreens. They are formulated to also include a water resistance agent and an insect repellent. One form has in an aqueous emulsion DEET, a sunscreen agent, an anionic surfactant, an alkylated PVP, and octyldodecyl neopentanoate. Methods for making and using such sunscreens are also disclosed.

Description

Anthelmintic sunscreen
The present invention relates to provide the sun-proof performance of high SPF and the compositions of good disinsectization performance.It can use under the frequent water-immersed environment of skin.
The tanned people's of ultraviolet meeting of the sun skin.Yet, be exposed to for a long time under the ultraviolet and have adverse influence, such as xerosis cutis, sunburn occurs, also can cause skin carcinoma under the extreme case.Thereby present technique has been developed sun-screening agent, comprises being coated to washing liquid and other material that helps skin to block solar ultraviolet on the skin or reduce its adverse effect.
People also usually wish not to be subjected to out of doors the invasion of mosquito and other winged insect.This can realize by apply a kind of anthelmintic separately on skin.Yet this needs twice independent coating and two kinds of independent products, and the composition in sunscreen and the anthelmintic exists not exclusively compatible danger.
Therefore, attempt to provide the single washing liquid that has sun-proof performance and disinsectization performance simultaneously.For example, see PCT patent application WO 95/19161 (1995) and United States Patent (USP) U.S.5,518,712; 5,346,922; 3,186,912 and 1,471,344. these disclosed patents and other all at this document of quoting as a reference, just as intactly setting forth at this.
Complicated factors is that people wish that user soaked in water even make situation become more, and after swimming by the sea, this protective agent is still effective.Therefore, the chemical compound of waterproof is added in this series products.For example, see PCT patent application WO 95/19161 (1995) and United States Patent (USP) U.S.5,518,712 and 4,810,489.
Yet, seeking the protective effect of high SPF, for example more than or equal to SPF 15, and good water repelling property and effectively during anthelmintic action, disadvantageous conflict can take place between each effective ingredient.Especially true for DEET (a kind of preferred anthelmintic effective ingredient).
In addition, people wish also can form when sun-screening agent is coated on the skin that one deck is smooth, even, the sunscreen film of non-greasy and have other good cosmetic properties.This has proposed extra problem for the developer of sunscreen.
Therefore, need a kind of improved anthelmintic sunscreen of exploitation.
On the one hand, the invention provides a kind of anthelmintic light screening composition.Wherein comprise percetage by weight and be 10% to 40% sunscreen, said sunscreen has absorbability in some zone of the ultraviolet radiation zone of 290-400nm at least.Comprise that also percetage by weight is 2% to 50% anthelmintic (preferably be lower than 25%, even more preferably be lower than 10%), percetage by weight is 1% to 20% the pivalate (C of preferred neopentanoic acid 30Or the even lower level Arrcostab, as Elefac I 205), percetage by weight is 20% to 60% water, and percetage by weight is 0.1% to 15% emulsifying agent (particularly preferably being anion emulsifier).Can also comprise waterproofing agent, be the polymer of 0.01% to 5% vinyl pyrrolidone as percetage by weight.
Elefac I 205 (C 25H 50O 2) on market, sold as a kind of emollient or skin isostearyl glyceryl pentaerythrityl ether ELEFAC I-205 by Bernel chemical company.Also can add other known emollient agent, for example liquid ester, silicone oil, mineral oil, allantoin, lanoline, vaseline, vegetable oil such as jojoba oil (jojoba oil) and Oleum Ricini, propylene glycol, and aliphatic alcohol such as hexadecanol and octadecanol.
Said anthelmintic preferably is selected from the group of being made up of following material: N, N-diethyl toluamide (" DEET "), N; N-diethylbenzene Methanamide, to  alkane-3, the 8-glycol; 1S; 3S, 4S, 6R-carene-3; 4 glycol (Sumitomo-United States Patent (USP) U.S.5; 130,136), the 1-methyl propyl ester of 2-(2-ethoxy)-1-piperidine carboxylic acid; 1-(3-cyclohexene-1-base-carbonyl)-pipecoline; 1-(3-cyclohexene-1-base-carbonyl) piperidines, N, N-diethyl mandelic acidamide (N; N-diethylmandelamide); the isopulegol hydrate, 3-[N-normal-butyl-N-acetyl group] the alanine ethyl ester, adipic acid diisopropyl ester (diisopropyladipate); α-di-sabal (biasabal); Oleum menthae, benzylalcohol, N; N-diethylbenzene acetamide; vitamin E, citronella oil, cloves oil; Oleum Cocois; Cedrus deoclar (Roxb.) G. Don oil, geraniol, Indian oil of verbena; thyme oil; oil of rosemary, Oleum menthae, oil of geranium; acetaminol; 3-acetyl group-2-(2,6-dimethyl-5-heptenyl) oxazolidine, (2-methylol cyclohexyl) acetic acid lactone and cineole.If use DEET, preferably DEET is in 7.5% to 30% scope.Yet under particular environment, such as the marsh that insecticide grows, more high-load DEET may be suitable.
Said sunscreen can be any skin coating reagent that is suitable for the people that photo absorption performance is arranged to some zone of 400nm at 290nm.Preferably be selected from the group of forming by following material: methoxy cinnamic acid 2-ethyl hexyl ester, salicylic acid 2-ethyl hexyl ester, 2-cyano group-3,3-diphenylacrylate 2-ethyl hexyl ester, oxybenzone (oxybenzone), p-(dimethylamino)-benzoic acid 2-ethyl hexyl ester (padimate O) and titanium dioxide.Yet, can also comprise the mixture of these components and/or other sunscreen, said other sunscreen such as amino benzoic Acid; Cinoxate (cinoxate); Right-diethanolamine methoxy cinnamate (diethanolamine p-methoxycinnamate); The trioleate of two galloyls (digalloyl trioleate); 4-methoxyl group-2,2 '-dihydroxy benzophenone (dioxybenzone); 4-[two (hydroxypropyl)] benzocaine; Para-amino benzoic acid glyceride; Salicylic acid front three cyclohexyl ester (homosalate); 2-hydroxyl-1,4-naphthoquinone (lawsone); Ortho-aminobenzoic acid  ester; 2-Phenylbenzimidazole-5-sulfonic acid; Red petrolatum; Hydroxyl methoxy benzophenone sulfonic acid; Zinc oxide and trolamine salicylate.
Said waterproofing agent is the polymer of vinyl pyrrolidone class preferably, in this base polymer, and the copolymer (" alkylating vinyl pyrrolidone (alkylated PVP) ") that forms of vinyl pyrrolidone and long-chain olefin preferably.For example see United States Patent (USP) U-S.4,810,489.Most preferred waterproofing agent is Ganex V-220, can obtain from GAF company.Ganex V-220 is the copolymer of 1-eicosylene and l-vinyl-2-pyrrolidone.Other suitable waterproofing agent have polyisobutylene (PrisorineSQS3758, Unichema); Tricontanvl PVP (Ganex WP-660-ISP); Acrylate/octyl acrylamide copolymer (Dermacryl-79; Versatyl-42; National Starch); Dimethicone 350 cSt (Dow); PVP/ hexadecene copolymer (Ganex V-216-ISP); Lexorez 100 (Inolex); Acrylate/acrylic acid C 10-30The cross linked polymer of Arrcostab and PemulenTR1/TR2 (Goodrich).
Thickening agent can help to reach the defencive function of higher SPF, though thickening agent for the contribution of SPF really the cutter reason know not fully aware ofly, it is by staying protecting film after the sunscreen composition and have contribution to realize using on skin obviously.Preferred thickening is silicate, stearic acid and the hexadecanol of HANSHENGJIAO (xanthan gum), guar gum, alginic acid glue (alginate gums), magnalium.Other suitable thickening is a silicate and clay class (bentonite for example, LAPONITE), polymeric thickening agent (as the acrylate copolymer (carbopolpolymers) of BF Goodrich), the Polyethylene Glycol thickening agent, cellulose thickener (as hydroxyethyl-cellulose), aliphatic alcohol and carbopol preparation (carbomers) (as CTFA).
The Amphisol (diethanolamine-cetyl phosphate) of said emulsifying agent preferred anionic surfactant such as Givaudan-Roure company.Yet, many other anion surfactants also can be used for this purpose, as the organic derivative of phosphate ester, phosphorus, sulfuric ester and ethoxylated alcohol, alkanolamide, sulfonation succinate, alkylaryl sulfonate and other surfactant based on protein, fluorocarbon and silicone of alcohol.
If necessary, also can add other conventional component of sun.These materials comprise silicone oil (for example Dow Silicone 200-dimethicone-a kind of lubricant), glycerol (a kind of film reinforcing agent), Germaben II (a kind of antiseptic) and spice.2-cyano group-3,3-diphenylacrylate 2-ethyl hexyl ester also can be used as additional sunscreen and add.This material is the commodity of BASF AG, Octocrylene by name.
On the one hand, the invention provides a kind of method, the exposed parts that it is included in human body applies this compositions, makes it not only have sun-proof function but also have function for expelling pests.On the other hand, the invention provides this method for compositions of manufacturing.
Even compositions of the present invention still has high SPF protective effect afterwards in immersing water.They also have superior anthelmintic action.Special design above-mentioned composition makes its SPF (" sun protection factor ") under " standard testing " (describing hereinafter) be at least SPF 15.This " standard testing " is the test of carrying out under the waterproof requirement not having.Yet as mentioned below, similarly test also can be carried out under submerged conditions.
" SPF 15 " popular understanding is exactly, and for example people will not spend 15 times time could shine into same degree after having under the condition of sunscreen tanned (burn) after under the sun 10 minutes, then applying this product on request.Yet,, determined SPF 15 (and SPF) more accurately according to " standard testing " in order to adapt to the requirement of this patent." the sun-proof pharmaceutical preparation motion of OTC " (" Proposed monogroph for OTC SunscreenDrug Products ") that this standard testing is normally announced on August 25th, 1978 according to Food and Drug Administration (Food and Drug Administration), Federal Register Volume 43, Number 166,38206-38269.
The light source of test usefulness is the Solar UltravioletSimulator that is produced by Solar Light company, Model 10S, and it is made up of one 150 watts xenon arc lamp and whole required optical element and a conventional power supply.Test group comprises 20 men and women experimenters, and they are the standard consideration/eliminatings according to the motion of FDA mentioned above.They confirm the sunburn of tested dorsal area, tanned, scar, the effectively existence of skin injury and/or uneven skin color by health check-up.The existence of nevolipoma (nevl), defective or nevus only otherwise the The Study of Interference result just can accept.The unnecessary fleece of back is wiped off.
Reference composition be 8% heliophan (homosalate, HMS).Each test site zone is used for determining the minimal erythema dose (minimal erythema dose) of experimenter after having applied the HMS tester of said sunscreen product or 8% (MED), or is used for determining that the experimenter does not add the MED under the condition of protection at skin.MED is the irradiation time that occurs minimum noticeable erythema in 16 hours back irradiation (post-exposure).The test position is the belt line at back and the zone between the omoplate, and the lateral attitude is then on center line.Said test site zone is square region preferably.
The area that is used to apply each test zone of product or standard control thing is 50 square centimeters.When the experimenter is in stand up position (position of just shining), retouch out the profile in these test site zones.Each test zone that is used for the HMS of tester and 8% all is divided into 1 square centimeter little test section.
For guaranteeing the spf value of standardized report and definite product, the coating consumption of product is represented with the weight basis on the unit are that forms standard film.The coating consumption of tested sunscreen product is 2mg/cm 2, 8% tester HMS also is like this.
For butterfat, high-viscosity gel and butyraceous material, said product want mild heat so that dosed administration by volume.In such heating process, must be carefully to guarantee not change the essential characteristics of product.After weighing, paste and ointment is coated in the test position.
After having applied product and will test the position and be exposed to before the ultraviolet radiation, there is 15 minutes waiting time.Be each experimenter's test cell to be carried out a series of irradiation under ultraviolet ray (a plurality of time quantum) then with solar simulator.
Thereby MED is determined in the irradiation of the untreated skin that does not add protection being carried out a series.The MED of the unprotected skin of experimenter determined on the same day of test.Ultraviolet radiation is also used in the test section of protected (using 8% HMS contrast and/or tested sunscreen product).
The interval of selecting is geometrical progression, and n represents with (1.25), and wherein, each irradiation time is all big by 25% than previous at interval.The value of the 3rd test cell is the spf value that is multiplied by the expection of MED.Therefore, the spf value of reporting is exactly that the med value of protected skin is divided by the med value of not protecting skin.
Similarly test can be used to estimate waterproof SPF.For this reason, the experimenter who has used sunscreen and tester was soaking 80 minutes in the water of an eddy current before the irradiation under ultraviolet ray.Be divided in these 80 minutes four 20 minutes, between per twice immersion arranged 20 minutes time of having a rest.Before irradiation under ultraviolet ray, experimenter's back will be at air drying.
Therefore purpose of the present invention comprises the compositions that the above-mentioned type is provided, and it has:
(a) protective effect of existing high SPF has good anthelmintic characteristic again;
(b) excellent waterproof SPF characteristic;
(c) Man Yi cosmetic properties, particularly relevant characteristic with Palmitoleic Acid; And
(d) no oils and fats sense.
These purposes of the present invention and other purpose (for example, make and use these method for compositions) will be conspicuous in the following description.Following description only is an embodiment preferred.So it should be noted that claims so that understand four corner of the present invention.
It below is the embodiments of the invention compositions.The numeral of listing below is a percetage by weight.
Raw material A ?B ?C ?D ?E
Stearic acid (Emersol 132) 5.00 ?4.00 ?5.00 ?4.00 ?5.00
Hexadecanol 2.00 ?1.60 ?2.00 ?1.60 ?2.00
Amphisol (DEA-16 phosphate esters) 2.00 ?2.00 ?2.00 ?2.00 ?2.00
Dow Silicone 200 (100cps) (polydimethylsiloxane) 0.50 ?0.50 ?0.50 ?0.50 ?0.50
Methoxy cinnamic acid octyl group ester 7.50 ?7.50 ?7.50 ?7.50 ?7.50
Elefac I 205 (Elefac I-205) 10.00 ?10.00 ?10.00 ?10.00 ?10.00
Salicylic acid octyl group ester 5.00 ?5.00 ?5.00 ?5.00 ?5.00
Benzophenone-3 (Benzophenone-3) 5.00 ?5.00 ?5.00 ?5.00 ?5.00
DEET 7.50 ?20.00 ?7.50 ?25.00 ?7.50
Deionized water 47.20 ?40.10 ?49.20 ?34.60 ?40.20
Zeopan (Veegum) 0.75 ?0.75 ?0.75 ?0.75 ?0.75
HANSHENGJIAO (Keltrol of Kelco) 0.25 ?0.25 ?0.25 ?0.25 ?0.25
Germaben IIE (antiseptic) 1.00 ?1.00 ?1.00 ?1.00 ?1.00
Ganex?V-200 2.00 ?2.00 ?2.00 ?2.50 ?2.00
Glycerol 4.00 ?4.00
Spice 0.30 ?0.30 ?0.30 ?0.30 ?0.30
Superfine Ti O2 (Cardre) ?2.00 ?2.00
Octocrylene ?2.00
100.00 ?100.00 ?100.00 ?100.00 ?100.00
As described below, the compositions of listing in the above that contains 7.5%DEET and a kind of 10%DEET of containing and SPF are among the contrast experiment of competitive sun-proof/anthelmintic commodity " Sunsect " of 15, although prescription A and C have used low DEET content, but still more said Sunsect 10% compositions has the better anti-performance of biting.In another contrast experiment, the Sunsect that prescription B contains anthelmintic and sun-proof component when containing 20%DEET compares.The result remains product comparison of the present invention has better insect protected performance than product.
Insect protected (insect protection) test is to carry out with the mode of a kind of " arm in the cage ".In these tests, the experimenter at first cleans arm with fancy soap, and water washes and dries then.Then with their forearm of product treatment of similar quantity,, then their forearm is exposed in the insecticide in the cage with the mitten of going up white.Insecticide type and quantity in the cage are described below.Details are as follows for these result of experiment.
In hour adjustment *Guard time
Sample Mosquito density Number of repetition Bite for the first time
A?7.5％DEET ?200 ?6 ?3.6
C?7.5％DEET ?200 ?6 ?2.6
Sunsect?10％ DEET ?200 ?6 ?2.4
*About three days test result
In hour average guard time
Sample Mosquito density Number of repetition Bite for the first time
B?20％DEET ?1000 ?6 ?5.3
Sunsect?20％ DEET ?1000 ?6 ?4.2
In hour average guard time
Sample Stable fly density Number of repetition Bite for the first time
B?20％DEET ?3000 ?6 ?0.9
Sunsect?20％ DEET ?3000 ?6 ?0.7
Compositions of the present invention has the spf value (using and the essentially identical method of testing of standard testing) that is at least 15 static state (static) (under anhydrous condition), also can keep good SPF to protect after immersion.Prescription A has the spf value of 16.3 static state and 15.8 waterproof spf value.Prescription B has the spf value of 16.2 static state and 14.7 waterproof spf value.Prescription C has the spf value of 26.3 static state and 24.6 waterproof spf value.Prescription D has the spf value of 16.5 static state and 15.8 waterproof spf value.Prescription E has the spf value of 34.5 static state and 31.8 waterproof spf value.
In order to make preferred compositions, preferably will dewater, the component outside glycerol, Veegum, Keltrol, spice and the Germaben mixes in first still, be heated to 180 °F and keep 15 minutes then until obtaining limpid yellow liquid.
In second still, G ﹠ W is mixed and be heated to 160 °F.The mixture of doing for preparing Veegum and Keltrol then separately.Under high shear mixing, it is added in second glycerol still at leisure.Stir the mixture and finish until hydration, mixture by thickening and caking not.This process typically needs 15 minutes under 160 °F.
Then the temperature of second glycerol still is risen to 175 °F.Content in first still mixed with it and this mixture was stirred 15 minutes.Then with mixture quenching to 110 and add Germaben and spice.This mixture is stirred 30 minutes postcooling to room temperature.
Preferred compositions can extruding, multiple abscess or is coated on people's the skin, smears then and drawout on skin.This process preferably carry out by a few minutes before sun exposure.
Should be noted that above description only is an embodiment preferred of the present invention.Many other embodiments are possible within the scope of claim.So it should be noted that claims so that judge four corner of the present invention.
Even sunscreen provided by the invention uses the anthelmintic activity composition of lower content also can obtain comparing the more superior disinsectization performance of competing product of photograph.It is particularly suitable for swimming out of doors or protection people's skin during sun tan.

Claims (15)

1. anthelmintic sunscreen composition is characterized in that comprising:
A. content 10wt% between the 40wt% at least 290 to the ultraviolet radiation ripple of 400nm
There is the organic sunscreen agent of photo absorption performance in some zone of section;
B. content at 2wt% to the anthelmintic between the 50wt%;
C. content at 1wt% to the pivalate between the 20wt%;
D. waterproofing agent;
E. content at 20wt% to the water between the 60wt%; And
F. content is at the emulsifying agent of 0.1wt% to 15wt%;
Wherein, the spf value of said compositions in " standard testing " is at least SPF 15.
2. according to the anthelmintic sunscreen composition of claim 1, wherein, said emulsifying agent is a kind of anion emulsifier.
3. according to the anthelmintic sunscreen composition of claim 2, wherein, said pivalate is a new pentane acid alkyl ester.
4. according to the anthelmintic sunscreen composition of claim 2, wherein, said pivalate is an Elefac I 205.
5. according to the anthelmintic sunscreen composition of claim 2, wherein, said waterproofing agent is the polymer of vinyl pyrrolidone.
6. according to the anthelmintic sunscreen composition of claim 5, wherein, the weight fraction in said compositions of said waterproofing agent is between 0.01% to 5%.
7. according to the anthelmintic sunscreen composition of claim 1, wherein, said waterproofing agent is the copolymer of polyvinyl pyrrolidone and alkene.
8. according to the anthelmintic sunscreen composition of claim 2, wherein, said anthelmintic is selected from the group of being made up of following material: N, N-diethyl toluamide, N, N-diethylbenzene Methanamide, to  alkane-3, the 8-glycol, the 1-methyl propyl ester of 2-(2-ethoxy)-1-piperidine carboxylic acid, 1-(3-cyclohexene-1-base carbonyl)-pipecoline, citronella oil, cloves oil, Oleum Cocois, Cedrus deoclar (Roxb.) G. Don oil, geraniol, Indian oil of verbena, thyme oil, oil of rosemary, Oleum menthae, oil of geranium and acetaminol.
9. anthelmintic sunscreen composition according to Claim 8, wherein, said anthelmintic is N, the N-diethyl toluamide.
10. according to the anthelmintic sunscreen composition of claim 2, wherein, said sunscreen is selected from the group of being made up of following material: methoxy cinnamic acid 2-ethyl hexyl ester, salicylic acid 2-ethyl hexyl ester, 2-cyano group-3,3-diphenylacrylate 2-ethyl hexyl ester, oxybenzone, p-(dimethylamino)-benzoic acid 2-ethyl hexyl ester and titanium dioxide.
11. according to the anthelmintic sunscreen composition of claim 10, wherein, said sunscreen is the mixture of methoxy cinnamic acid 2-ethylhexyl ester, salicylic acid 2-Octyl Nitrite and oxybenzone.
12. according to the anthelmintic sunscreen composition of claim 2, it is characterized in that also comprising a kind of thickening agent, said thickening agent is selected from the group of being made up of following material: silicate, stearic acid and the hexadecanol of HANSHENGJIAO, guar gum, alginic acid glue, magnalium.
13., it is characterized in that also comprising silicone oil and spice according to the anthelmintic sunscreen composition of claim 12.
14. a part that exposes at human body applies said compositions so that said compositions has sun-proof and method anthelmintic action, it is included in the step of human body skin coating according to the compositions of claim 1.
15. the not only sun-proof but also anthelmintic method for compositions of manufacturing comprises sunscreen, anthelmintic, pivalate, waterproofing agent and emulsifying agent according to claim 1 is mixed with water to obtain the compositions according to claim 1.
CNB97196789XA 1996-06-26 1997-06-26 Insect repellent sunscreen Expired - Fee Related CN1172654C (en)

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US5716602A (en) 1998-02-10
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CA2259292C (en) 2002-11-19
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AU713810B2 (en) 1999-12-09
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DE69716429D1 (en) 2002-11-21

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