CN116999681A - Sustained-release injection device for brain room and use method - Google Patents
Sustained-release injection device for brain room and use method Download PDFInfo
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- CN116999681A CN116999681A CN202310971675.XA CN202310971675A CN116999681A CN 116999681 A CN116999681 A CN 116999681A CN 202310971675 A CN202310971675 A CN 202310971675A CN 116999681 A CN116999681 A CN 116999681A
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- 238000002347 injection Methods 0.000 title claims abstract description 79
- 239000007924 injection Substances 0.000 title claims abstract description 79
- 210000004556 brain Anatomy 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 16
- 238000013268 sustained release Methods 0.000 title claims description 35
- 239000012730 sustained-release form Substances 0.000 title claims description 35
- 239000003814 drug Substances 0.000 claims abstract description 112
- 229940079593 drug Drugs 0.000 claims abstract description 58
- 239000002775 capsule Substances 0.000 claims description 143
- 229940044683 chemotherapy drug Drugs 0.000 claims description 55
- 239000002246 antineoplastic agent Substances 0.000 claims description 54
- 239000012528 membrane Substances 0.000 claims description 45
- 206010028980 Neoplasm Diseases 0.000 claims description 23
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 17
- 230000000973 chemotherapeutic effect Effects 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 17
- 210000003140 lateral ventricle Anatomy 0.000 claims description 15
- 230000002490 cerebral effect Effects 0.000 claims description 11
- 238000012423 maintenance Methods 0.000 claims description 10
- 238000007917 intracranial administration Methods 0.000 claims description 8
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 7
- 206010011732 Cyst Diseases 0.000 claims description 5
- 238000003556 assay Methods 0.000 claims description 5
- 208000031513 cyst Diseases 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 238000012544 monitoring process Methods 0.000 claims description 5
- 230000002093 peripheral effect Effects 0.000 claims description 5
- 210000003625 skull Anatomy 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 238000002512 chemotherapy Methods 0.000 abstract description 11
- 208000015181 infectious disease Diseases 0.000 abstract description 8
- 230000000694 effects Effects 0.000 description 10
- 229940126585 therapeutic drug Drugs 0.000 description 5
- 230000008569 process Effects 0.000 description 4
- 208000003174 Brain Neoplasms Diseases 0.000 description 3
- 210000004958 brain cell Anatomy 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 2
- 210000002726 cyst fluid Anatomy 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- 208000000172 Medulloblastoma Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 208000012851 brain cyst Diseases 0.000 description 1
- 230000007052 brain toxicity Effects 0.000 description 1
- 231100000976 cerebrotoxicity Toxicity 0.000 description 1
- 238000009104 chemotherapy regimen Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000007914 intraventricular administration Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000011248 postoperative chemotherapy Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3415—Trocars; Puncturing needles for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0077—Cerebrospinal fluid
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
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- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a slow release injection device for a brain chamber and a use method thereof, and particularly relates to the technical field of medical equipment. The invention can reduce puncture frequency, reduce pain and infection risk of patients, maintain the stability of drug release, reduce fluctuation of drug concentration and play a role in better chemotherapy.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a slow-release injection device for a brain room and a use method thereof.
Background
Ommaya capsule is a mushroom-like device for ventricular injection, which is connected to a ventricular drainage tube, and is mainly used for treating intracranial infection and malignant tumor. It was named after its inventor Ayub Khan Ommaya in 1963. In the last 60 th century, the world has not been able to effectively provide chemotherapy assistance to brain tumor patients because of the blood brain barrier, and Ommaya's capsule can be used to treat invasive brain tumors by injecting drugs into the brain cells through the drainage catheter and into the cerebrospinal fluid, and the device is also the prototype of the current port of infusion. The Ommaya capsule invention has been widely used in clinic for 60 years so far, for example, a medulloblastoma chemotherapy regimen HIT-SKK-92 regimen has been the standard administration route of postoperative chemotherapy for infants under 3 years old, and administration of intraventricular chemotherapy by the Ommaya capsule route after meningeal metastasis has become the standard regimen, however, there has been no substantial improvement of Ommaya capsules for 60 years so far, and further improvement and innovation of Ommaya capsules for the purpose of improving the effect of chemotherapy are urgently required in the current clinical practice.
The current Ommaya capsule comprises a mushroom-shaped self-sealing liquid storage capsule and a drainage tube, the drainage tube can reach the lateral ventricle through a small hole formed in the skull, the material of the dome of the liquid storage capsule is specially thickened silica gel, the liquid storage capsule can be pressed, and the needle eye can be healed by itself after puncture, so that the liquid storage capsule can be subjected to repeated puncture. While the first idea of the Ommaya invention reservoir device is to hope for delivering an antifungal drug to the cerebrospinal fluid, the Ommaya reservoir is now most commonly used for chemotherapy administration of intracranial malignant tumors and cerebrospinal fluid sampling. At present, the mode of treating malignant brain tumor patients is greatly improved by injecting the chemotherapeutic drugs into the Ommaya capsule, but because the traditional Ommaya capsule does not have a slow release function, when the chemotherapeutic drugs are injected into the Ommaya capsule, the concentration of the drugs in the brain chamber has obvious peak-valley fluctuation, and when the blood concentration is in the trough, the concentration is likely to be lower than the treatment concentration and can not exert the curative effect, thereby limiting the further improvement of the anti-tumor curative effect of the chemotherapeutic drugs. For example, the intrathecal injection chemotherapy scheme published by the billow professor team in the international journal Journal ofThoracic Oncology needs to be injected for 2 times per week to keep the concentration of the drug to have a therapeutic effect, but frequent puncture injection brings pain to patients and increases infection risk, and meanwhile, the sustained stability of the chemotherapeutic drug cannot be maintained because of not having a slow release function.
Chinese patent CN207237071U discloses a time-controlled Ommaya capsule, which comprises a medicine storage capsule, a medicine injection capsule and a liquid discharge capsule, wherein the medicine storage capsule with the diameter of 1.2-2 cm is required to be placed in a ventricle operation area, and for the conventional Ommaya operation which only needs to put a 2-3mm catheter into a lateral ventricle after skull micro-holes are formed, the operation required by placing the 1.2-2 cm medicine storage capsule in the ventricle operation area is more complex and the operation risk is higher; in addition, according to the description, the semipermeable membrane outer wall of the medicine storage bag can only realize that water molecules of the brain enter the outer bag, and the liquid storage bag is used for extracting effusion from an operation area for decompression, so that the function of extracting turbid cerebrospinal fluid invaded by tumors in the brain chamber can not be realized; and the drug storage bag only depends on the semipermeable membrane to realize the release of the drug, the difference of the solution contents in the inner bag and the outer bag influences the release speed of the drug, the drug release process is unstable, the peak Gu Xianxiang cannot be avoided, the bioavailability is reduced, the drug effect of the drug is influenced, and the chemotherapy effect is further reduced.
Disclosure of Invention
The invention aims to provide a slow release injection device for a brain room and a use method thereof, which are used for solving the problems in the prior art, reducing puncture frequency, reducing pain and infection risk of a patient, ensuring the stability of drug release speed, reducing fluctuation of drug concentration, maintaining the stability of the drug concentration in the brain, improving bioavailability and playing a better role in chemotherapy.
In order to achieve the above object, the present invention provides the following solutions:
the invention provides a sustained-release injection device used in a brain chamber, which comprises a first capsule cavity, a second capsule cavity, a sustained-release capsule cavity and a double-cavity catheter, wherein the double-cavity catheter comprises a first catheter and a second catheter which are mutually independent, the sustained-release capsule cavity is connected and communicated with the first catheter, the sustained-release capsule cavity is provided with an elastic moving component and a semipermeable membrane, the semipermeable membrane is fixedly connected with the inner peripheral side wall of one end of the sustained-release capsule cavity close to the first catheter, the semipermeable membrane is used for enabling medicine in the sustained-release capsule cavity to flow into the first catheter in a unidirectional way, one end of the elastic moving component is fixedly connected with the inner wall of the sustained-release capsule cavity, the elastic moving component can deform and recover to enable the other end of the elastic moving component to be connected with the inner side wall of the sustained-release capsule cavity in a sliding and sealing way, the first capsule cavity comprises a first medicine injection part and a first medicine injection pipe, one end of the first medicine injection pipe is connected and communicated with the first medicine injection part, the other end of the first semi-permeable membrane is connected and communicated with the sustained-release capsule cavity, the other end of the first medicine injection pipe is connected with the second capsule cavity and the second medicine injection pipe, the second capsule cavity is positioned at the position far from the second end of the first capsule cavity and the second capsule cavity, and the second capsule cavity is fixedly connected with the second capsule cavity, and the other end of the first capsule cavity is inserted into the second capsule cavity.
Preferably, one end of the first medicine injection tube, which is close to the slow release capsule cavity, is provided with a one-way valve, and the one-way valve is used for enabling medicine to flow into the slow release capsule cavity from the first capsule cavity in a one-way manner.
Preferably, the elastic moving assembly comprises an elastic piece and a moving piece, one end of the elastic piece is abutted with one end of the slow-release capsule away from the first catheter, the other end of the elastic piece is abutted with the moving piece, the circumferential outer side wall of the moving piece can be tightly attached to the inner side wall of the slow-release capsule, and the elastic piece deforms and recovers to deform to enable the moving piece to be close to or far away from the semipermeable membrane along the axial direction of the slow-release capsule.
Preferably, the elastic member is located near the semipermeable membrane when in a natural state.
Preferably, the elastic piece is a plastic spring or a titanium spring.
Preferably, a plurality of first side holes are uniformly formed in the outer side wall of one end, far away from the slow-release capsule cavity, of the first catheter, the first side holes are used for enabling medicines of the first catheter to flow into the lateral ventricle, a plurality of second side holes are uniformly formed in the outer side wall of one end, far away from the slow-release capsule cavity, of the second catheter, and the second side holes are used for enabling medicines of the second catheter to flow into the lateral ventricle and turbid cerebrospinal fluid in the lateral ventricle to flow into the second catheter.
Preferably, the device further comprises a fixing piece, one end of the fixing piece is fixedly connected with the double-cavity catheter, and the other end of the fixing piece is fixedly connected with the skull or the cap-shaped aponeurosis.
Preferably, the device further comprises a titanium wire mesh, wherein the titanium wire mesh is fixedly connected with the inner peripheral side wall of the slow-release capsule cavity, the titanium wire mesh is close to the first catheter compared with the semipermeable membrane, and the semipermeable membrane can be in contact with the titanium wire mesh.
The invention also provides a using method of the slow release injection device for the brain chamber, which comprises the following steps:
injecting a loading dose of a chemotherapeutic drug into the second drug injection part, wherein the chemotherapeutic drug flows into intracranial tumor or ventricle through the second drug injection tube and the second catheter to play a basic chemotherapeutic role;
injecting a maintenance dose of a chemotherapeutic drug into the first capsule cavity, enabling the chemotherapeutic drug to enter the slow-release capsule cavity through the first drug injection tube and compressing the elastic moving assembly in a direction away from the semipermeable membrane to deform the elastic moving assembly, enabling the elastic moving assembly to generate thrust to the chemotherapeutic drug through restoring deformation, and enabling the chemotherapeutic drug to stably flow into the first catheter through the semipermeable membrane and then enter the cyst tumor inside or ventricle inside the brain;
after a period of time of injecting a maintenance dose of a chemotherapeutic drug into the first capsule cavity, a suction device is inserted into the second capsule cavity to extract a cerebral chamber or tumor capsule liquid, the cerebral chamber or tumor capsule liquid flows into the second capsule cavity through the second catheter, one part of the extracted cerebral chamber or tumor capsule liquid is used for sample assay, the other part of the extracted cerebral chamber or tumor capsule liquid is used for drug concentration detection, and the dose and the administration frequency of the chemotherapeutic drug injected into the first capsule cavity are individually adjusted according to the drug concentration monitoring result.
Compared with the prior art, the invention has the following technical effects:
the invention provides a slow release injection device for a brain chamber and a use method thereof, firstly, a chemotherapeutic drug capable of realizing loading dose is injected into a second sac cavity, the chemotherapeutic drug enters into the intracranial tumor or the brain chamber through a second drug injection tube and a second catheter to play a role of basic chemotherapy, and in order to maintain the treatment effect of the therapeutic drug, the therapeutic drug in the intracranial tumor or the brain chamber needs to be kept at a certain concentration. Then, the chemotherapeutic medicine with the maintenance dose is injected into the first capsule cavity, the chemotherapeutic medicine enters the slow-release capsule cavity through the first medicine injection pipe, and the chemotherapeutic medicine enters the slow-release capsule cavity, because the speed of the chemotherapeutic medicine penetrating through the semipermeable membrane is slower, the chemotherapeutic medicine entering the slow-release capsule cavity firstly extrudes the elastic moving component to deform under the certain blocking action of the semipermeable membrane, and the elastic moving component also recovers deformation along with the part of the chemotherapeutic medicine flowing into the first pipe from the semipermeable membrane, and the chemotherapeutic medicine is pushed to flow into the first pipe at a stable flow rate when the elastic moving component recovers deformation, namely, the chemotherapeutic medicine can flow into the brain of a patient at a stable dosage, so that the concentration of the chemotherapeutic medicine is favorable for maintaining, the defect of unstable medicine concentration caused by the traditional Ommaya capsule pulse type administration is overcome, the brain toxicity of the medicine to the patient is effectively reduced, the chemotherapeutic treatment effect is improved, and the survival time of the patient is prolonged; the first and second capsule cavities are respectively communicated with the first and second catheters which are mutually independent, so that the administration of loading dose and maintenance dose can be realized at the same time, and the first and second capsule cavities independently operate on the aspect of drug delivery, thereby avoiding the problem of drug stringing; the release rate of the chemotherapy drugs in the slow-release capsule cavity is stable, the peak Gu Xianxiang of the drug concentration is avoided to a certain extent, the frequency of the injection needle for frequently injecting the drugs into the capsule cavity due to the low drug concentration is reduced, the pain of a patient is relieved, and the infection rate is also reduced; the brain chamber or tumor cyst fluid can be extracted back through the second cyst chamber for specimen assay and drug concentration detection, so that the slow release effect of the slow release structure can be dynamically adjusted and monitored, the chemotherapeutic drugs can be added in a personalized manner in time, and the concentration of the chemotherapeutic drugs is ensured.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural view of a sustained release injection apparatus for brain cells according to the present invention;
FIG. 2 is a side view of the sustained release injection apparatus for use in the brain chamber of the present invention after injection of a drug into the first or second capsule;
fig. 3 is a side view of the first or second capsule of the sustained release injection apparatus for brain cells of the present invention without drug injection.
In the figure: 1-a first capsule; 11-a first injection part; 12-a first injection tube; 13-a one-way valve; 2-a second capsule; 21-a second injection part; 22-a second injection tube; 3-slow release capsule; 31-a semipermeable membrane; 32-an elastic member; 33-moving member; 4-double lumen catheter; 41-a first conduit; 411-first side hole; 42-a second conduit; 421-second side hole; 5-fixing pieces; 6-connecting piece.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention aims to provide a slow release injection device for a brain room and a use method thereof, which are used for solving the problems in the prior art, reducing puncture frequency, reducing pain and infection risk of a patient, ensuring the stability of drug release speed, reducing fluctuation of drug concentration, maintaining the stability of the drug concentration in the brain, improving bioavailability and playing a better role in chemotherapy.
In order that the above-recited objects, features and advantages of the present invention will become more readily apparent, a more particular description of the invention will be rendered by reference to the appended drawings and appended detailed description.
Example 1
The embodiment provides a sustained release injection device for a brain chamber, as shown in fig. 1-3, which comprises a first capsule cavity 1, a second capsule cavity 2, a sustained release capsule cavity 3 and a double-cavity catheter 4, wherein the double-cavity catheter 4 comprises a first catheter 41 and a second catheter 42 which are mutually independent, the sustained release capsule cavity 3 is connected and communicated with the first catheter 41, the sustained release capsule cavity 3 is provided with an elastic moving component and a semipermeable membrane 31, the semipermeable membrane 31 is fixedly connected with the side wall of one end of the sustained release capsule cavity 3, which is close to the first catheter 41, of the semipermeable membrane 31, the drug in the sustained release capsule cavity 3 flows into the first catheter 41 in one direction, one end of the elastic moving component is fixedly connected with the inner wall of the sustained release capsule cavity 3, the elastic moving component can deform and recover to deform, the other end of the elastic moving component is connected with the inner side wall of the sustained release capsule cavity 3 in a sliding and sealing way, the first capsule cavity 1 comprises a first drug injection part 11 and a first drug injection tube 12, one end of the first medicine injection pipe 12 is connected and communicated with the first medicine injection part 11, the other end of the first medicine injection pipe 12 is connected and communicated with the slow release sac 3, the connection position of the first guide pipe 41 and the slow release sac 3 is positioned between the semipermeable membrane 31 and the elastic moving component, the second sac 2 comprises a second medicine injection part 21 and a second medicine injection pipe 22, one end of the second medicine injection pipe 22 is connected and communicated with the second medicine injection part 21, the other end of the second medicine injection pipe 22 is fixedly connected and communicated with the second guide pipe 42, the first sac 1, the second sac 2, the slow release sac 3 and the double-cavity guide pipe 4 are all used for being arranged at the lower part of the scalp, one end of the double-cavity guide pipe 4 far from the slow release sac 3 can be inserted into a lateral ventricle, after one end of the double-cavity guide pipe 4 is inserted into the lateral ventricle, medicine can flow to the lateral ventricle, a doctor can cut the double-cavity guide pipe 4 according to the insertion depth of different patients in the operation of the slow release device, then, the two sections of the cut double-cavity catheters 4 are spliced together by adopting the connecting piece 6, the first catheter 41 and the second catheter 42 of the spliced double-cavity catheters 4 are always independent, and drug mixed flow does not occur at the splicing position, the chemotherapeutic drugs enter the intracranial tumor or ventricle through the second drug injection tube 22 and the second catheter 42 to play a basic role in chemotherapy, after the chemotherapeutic drugs with the loading dose are injected, the therapeutic effect of the therapeutic drugs is maintained, namely, the therapeutic drugs keep a certain concentration, the chemotherapeutic drugs with the maintaining dose are injected into the first capsule cavity 1, the chemotherapeutic drugs enter the slow-release capsule cavity 3 through the first drug injection tube 12, the speed of the chemotherapeutic drugs passing through the semipermeable membrane 31 is lower, therefore, a large amount of the chemotherapeutic drugs can deform the elastic moving assembly, and the elastic moving assembly slowly recovers to deform along with the fact that part of the chemotherapeutic drugs flow into the inside of the brain cyst or ventricle through the semipermeable membrane 31, and the elastic moving assembly recovers to deform and simultaneously applies the chemotherapeutic drugs to the chemotherapeutic drugs, so that the chemotherapeutic drugs can flow into the first catheter 41 to provide proper concentration for survival time of the patient, thereby reducing the therapeutic effect of the patient, and improving the survival time of the therapeutic drugs; the first and second sacs 1 and 2 are respectively communicated with the first and second catheters 41 and 42 which are independent of each other, so that the administration of loading dose and maintenance dose can be realized at the same time, and the first and second sacs 1 and 2 independently operate in the process of delivering medicine, thereby avoiding the problem of medicine cross; the release rate of the chemotherapy drugs in the slow-release capsule cavity 3 is stable, the peak Gu Xianxiang of the drug concentration is avoided to a certain extent, the frequency of injecting the drugs into the capsule cavity by the injection needle because the drug concentration is low and the scalp is required to be punctured is reduced, the pain of patients is relieved, and the infection rate is also reduced; the brain chamber or tumor cyst fluid can be extracted back through the second cyst cavity 2 for specimen assay and drug concentration detection, so that the slow release effect of the slow release structure can be dynamically adjusted and monitored, the chemotherapeutic drugs can be added in a personalized manner in time, and the concentration of the chemotherapeutic drugs is ensured. The present embodiment can control the flow rate of the medicine by the elasticity of the spring or the provision of the multi-layered semipermeable membrane 31 to meet the requirements of different patients for the flow rate of the medicine.
In this embodiment, it is further preferable that one end of the first injection tube 12 near the slow release capsule cavity 3 is provided with a one-way valve 13, the one-way valve 13 is used for making the medicine flow into the slow release capsule cavity 3 from the first capsule cavity 1 in one direction, and the elastic moving component prevents the chemotherapeutic medicine from flowing back to the first capsule cavity 1 under the thrust force in the process of restoring deformation to push the chemotherapeutic medicine to flow into the first conduit 41 through the semipermeable membrane 31 at a stable flow rate, so that the chemotherapeutic medicine entering the slow release capsule cavity 3 can only flow out from the semipermeable membrane 31.
In this embodiment, it is further preferable that the elastic moving component includes an elastic member 32 and a moving member 33, one end of the elastic member 32 is abutted against one end of the slow release capsule 3 away from the first catheter 41, the other end of the elastic member 32 is abutted against the moving member 33, the circumferential outer side wall of the moving member 33 can be tightly abutted against the inner side wall of the slow release capsule 3, the elastic member 32 deforms and recovers deformation to enable the moving member 33 to be close to or far away from the semipermeable membrane along the axial direction of the slow release capsule 3, after the maintenance dose of the chemotherapeutic drug is injected into the first capsule 1, the chemotherapeutic drug enters the slow release capsule 3 through the first drug injection tube 12 and moves the moving member 33 towards the direction of the elastic member 32, and compresses the elastic member 32, the circumferential outer side wall of the moving member 33 is tightly abutted against the inner side wall of the slow release capsule 3, the chemotherapeutic drug cannot flow to the side of the moving member 33 close to the elastic member 32, and can only be stored on the side of the moving member 33 away from the elastic member 32, and the elastic member 32 pushes the chemotherapeutic drug to permeate the semipermeable membrane 31 at a stable flow rate under the elastic force of recovering deformation so as to achieve the slow release effect.
It is further preferable in the embodiment of this embodiment that the elastic member 32 is in a natural state, and the moving member 33 is located close to the semipermeable membrane 31, so that most of the chemotherapeutic agent in the slow release capsule 3 can be pushed to flow out of the semipermeable membrane at a stable speed during the process of recovering the deformation of the elastic member 32.
It is further preferable in the implementation of this embodiment that the elastic member 32 is a plastic spring or a titanium spring, and the plastic spring or the titanium spring does not affect the patient to perform the magnetic resonance examination.
It is further preferable in the implementation of this embodiment that the outer side wall of the end of the first catheter 41 far from the slow release capsule 3 is uniformly provided with a plurality of first side holes 411, the first side holes 411 are used for enabling the chemotherapeutic drugs of the first catheter 41 to flow into the lateral ventricle, the outer side wall of the end of the second catheter 42 far from the slow release capsule 3 is uniformly provided with a plurality of second side holes 421, the second side holes 421 are used for enabling the drugs of the second catheter 42 to flow into the lateral ventricle and turbid cerebrospinal fluid in the lateral ventricle to flow into the second catheter 42, and the first side holes 411 and the second side holes 421 can enable the chemotherapeutic drugs to uniformly flow into the lateral ventricle.
It is further preferable in the implementation of this embodiment that the sustained release injection device for brain chamber further includes a fixing member 5, one end of the fixing member 5 is fixedly connected with the double-lumen catheter 4, the other end of the fixing member 5 is fixedly connected with the skull or hat-shaped aponeurosis, and the fixing member 5 can fix the double-lumen catheter 4 at the lower part of the scalp to avoid movement.
It is further preferable in the embodiment of the present embodiment that the sustained-release injection apparatus for brain chamber further includes a titanium mesh, the titanium mesh is fixedly connected with the inner peripheral side wall of the sustained-release capsule 3, the titanium mesh is closer to the first conduit 41 than the semipermeable membrane 31, and the semipermeable membrane 31 can be contacted with the titanium mesh, and a mesh-shaped titanium mesh is provided in front of the semipermeable membrane 31 for protecting the semipermeable membrane 31 and preventing the semipermeable membrane 31 from being damaged due to long-term compression.
Example 2
The present embodiment provides a method for using the sustained release injection apparatus for brain room of embodiment 1, comprising the steps of:
injecting a loading dose of a chemotherapeutic drug into the second drug injection part 21, wherein the chemotherapeutic drug flows into the intracranial tumor or ventricle through the second drug injection tube 22 and the second catheter 42 to play a basic chemotherapeutic role;
injecting a maintenance dose of a chemotherapeutic drug into the first capsule cavity 1, enabling the chemotherapeutic drug to enter the slow release capsule cavity 3 through the first drug injection tube 12 and compressing the elastic moving component in a direction away from the semipermeable membrane 31, so that the elastic moving component deforms, and the elastic moving component generates thrust to the chemotherapeutic drug through restoring deformation, so that the chemotherapeutic drug can stably flow into the first catheter 41 through the semipermeable membrane 31 and further enter the cyst tumor or ventricle in the brain;
after a period of time after the injection of the maintenance dose of the chemotherapeutic drug into the first capsule cavity 1, a suction device is inserted into the second capsule cavity 2 to extract the cerebral chamber or tumor capsule liquid, the cerebral chamber or tumor capsule liquid flows into the second capsule cavity 2 through the second conduit 42, one part of the extracted cerebral chamber or tumor capsule liquid is used for sample assay, the other part is used for drug concentration detection, and the dose and the administration frequency of the chemotherapeutic drug injected into the first capsule cavity 1 are individually adjusted according to the drug concentration monitoring result.
By the method for monitoring the slow release dynamics of the chemotherapeutic drugs, the puncture frequency can be reduced, the pain and infection risk of patients can be reduced, the dynamic adjustment of the chemotherapeutic drugs can be realized by matching with the drug concentration monitoring, the stability of drug release is ensured, the drug concentration is maintained, the slow release efficacy of the slow release structure is monitored, the chemotherapeutic drugs can be individually and timely added, and the chemotherapeutic effect is ensured.
The principles and embodiments of the present invention have been described in detail with reference to specific examples, which are provided to facilitate understanding of the method and core ideas of the present invention; also, it is within the scope of the present invention to be modified by those of ordinary skill in the art in light of the present teachings. In summary, the present description should not be construed as limiting the invention.
Claims (9)
1. A sustained release injection apparatus for use in a brain chamber, characterized by: the device comprises a first capsule cavity, a second capsule cavity, a slow release capsule cavity and a double-cavity catheter, wherein the double-cavity catheter comprises a first catheter and a second catheter which are mutually independent, the slow release capsule cavity is connected and communicated with the first catheter, the slow release capsule cavity is provided with an elastic moving component and a semipermeable membrane, the semipermeable membrane is close to one end inner peripheral side wall of the first catheter and fixedly connected with the slow release capsule cavity, the semipermeable membrane is used for enabling medicine in the slow release capsule cavity to flow into the first catheter in a unidirectional mode, one end of the elastic moving component is fixedly connected with the inner wall of the slow release capsule cavity, the elastic moving component can deform and recover deformation, the other end of the elastic moving component is connected with the inner side wall of the slow release capsule cavity in a sliding and sealing mode, the first capsule cavity comprises a first medicine injection part and a first medicine injection pipe, one end of the first medicine injection pipe is connected and communicated with the first medicine injection part, the first end of the slow release capsule cavity is connected and communicated with the slow release capsule cavity, the first catheter and the connecting position of the slow release capsule cavity is located between the elastic moving component and the second medicine injection part, the two end of the slow release capsule cavity is far from the first end of the first medicine injection pipe and the second medicine injection part is connected with the second medicine injection pipe.
2. The sustained release injection apparatus for use in a brain room according to claim 1, wherein: one end of the first medicine injection tube, which is close to the slow release capsule cavity, is provided with a one-way valve, and the one-way valve is used for enabling medicine to flow into the slow release capsule cavity from the first capsule cavity in one way.
3. The sustained release injection apparatus for use in a brain room according to claim 1, wherein: the elastic moving assembly comprises an elastic piece and a moving piece, one end of the elastic piece is abutted with one end of the slow-release capsule away from the first catheter, the other end of the elastic piece is abutted with the moving piece, the circumferential outer side wall of the moving piece can be tightly attached to the inner side wall of the slow-release capsule, and the elastic piece deforms and resumes deformation to enable the moving piece to be close to or far away from the semipermeable membrane along the axial direction of the slow-release capsule.
4. A sustained release injection apparatus for use in a brain chamber according to claim 3, wherein: when the elastic piece is in a natural state, the movable piece is positioned close to the semipermeable membrane.
5. The sustained release injection apparatus for use in a brain room according to claim 4, wherein: the elastic piece is a plastic spring or a titanium spring.
6. The sustained release injection apparatus for use in a brain room according to claim 1, wherein: the side wall of one end of the first catheter, which is far away from the slow-release capsule cavity, is uniformly provided with a plurality of first side holes, the first side holes are used for enabling medicines of the first catheter to flow into the lateral ventricle, the side wall of one end of the second catheter, which is far away from the slow-release capsule cavity, is uniformly provided with a plurality of second side holes, and the second side holes are used for enabling medicines of the second catheter to flow into the lateral ventricle and turbid cerebrospinal fluid in the lateral ventricle to flow into the second catheter.
7. The sustained release injection apparatus for use in a brain room according to claim 1, wherein: the device also comprises a fixing piece, one end of the fixing piece is fixedly connected with the double-cavity catheter, and the other end of the fixing piece is fixedly connected with the skull or the cap-shaped aponeurosis.
8. The sustained release injection apparatus for use in a brain room according to claim 1, wherein: the device further comprises a titanium wire mesh, wherein the titanium wire mesh is fixedly connected with the inner peripheral side wall of the slow-release capsule cavity, the titanium wire mesh is close to the first catheter compared with the semipermeable membrane, and the semipermeable membrane can be in contact with the titanium wire mesh.
9. A method of using a sustained release injection apparatus for use in a brain chamber as claimed in any one of claims 1 to 8, comprising the steps of:
injecting a loading dose of a chemotherapeutic drug into the second drug injection part, wherein the chemotherapeutic drug flows into intracranial tumor or ventricle through the second drug injection tube and the second catheter to play a basic chemotherapeutic role;
injecting a maintenance dose of a chemotherapeutic drug into the first capsule cavity, enabling the chemotherapeutic drug to enter the slow-release capsule cavity through the first drug injection tube and compressing the elastic moving assembly in a direction away from the semipermeable membrane to deform the elastic moving assembly, enabling the elastic moving assembly to generate thrust to the chemotherapeutic drug through restoring deformation, and enabling the chemotherapeutic drug to stably flow into the first catheter through the semipermeable membrane and then enter the cyst tumor inside or ventricle inside the brain;
after a period of time of injecting a maintenance dose of a chemotherapeutic drug into the first capsule cavity, a suction device is inserted into the second capsule cavity to extract a cerebral chamber or tumor capsule liquid, the cerebral chamber or tumor capsule liquid flows into the second capsule cavity through the second catheter, one part of the extracted cerebral chamber or tumor capsule liquid is used for sample assay, the other part of the extracted cerebral chamber or tumor capsule liquid is used for drug concentration detection, and the dose and the administration frequency of the chemotherapeutic drug injected into the first capsule cavity are individually adjusted according to the drug concentration monitoring result.
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