CN116983363B - Traditional Chinese medicine composition for promoting rapid wound healing and preparation method thereof - Google Patents
Traditional Chinese medicine composition for promoting rapid wound healing and preparation method thereof Download PDFInfo
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- CN116983363B CN116983363B CN202310888549.8A CN202310888549A CN116983363B CN 116983363 B CN116983363 B CN 116983363B CN 202310888549 A CN202310888549 A CN 202310888549A CN 116983363 B CN116983363 B CN 116983363B
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Abstract
The invention provides a traditional Chinese medicine composition for promoting rapid wound healing and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials: radix Ampelopsis, semen Cuscutae, agrimonia, herba Macleayae Cordatae, herba Pyrolae, herba Portulacae, herba Menthae, radix Angelicae sinensis, fructus Sophorae, fructus Chebulae, herba Schizonepetae, radix astragali, glycyrrhrizae radix, radix Cynanchi Paniculati, herba Sedi, herba asari, radix Angelicae Dahuricae, fructus Xanthii, radix Saposhnikoviae, fructus forsythiae, folium Platycladi, cortex Ilicis Rotundae, radix Trichosanthis, rhizoma Drynariae, rhizoma Bletillae, spina Gleditsiae, galla chinensis, carapax et Plastrum Testudinis, herba Scutellariae Barbatae, nodus Nelumbinis Rhizomatis, os Sepiae, cortex Dictamni Radicis, and fructus Zanthoxyli. The traditional Chinese medicine composition disclosed by the invention is reasonable in proportion, good in stability, strong in sterilization capability, capable of effectively resisting pathogenic microorganisms, effectively preventing wound infection, promoting wound cell regeneration, accelerating wound healing, reducing wound scar and strong in action effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for promoting rapid wound healing and a preparation method thereof.
Background
In daily life, the skin covering the whole body is affected by pathogenic microorganisms, chemical, mechanical and physical factors, so that the surface of the skin is damaged in a wound manner, the tissue structure around the skin is damaged, and the normal function of the skin is affected. If the wound is unable to heal early, bacterial and fungi and the like can easily enter the wound to cause infection, so that the wound is suppurative and difficult to scab and heal, and severe septicemia can also be caused. At present, some traditional Chinese medicine formulas for promoting wound healing appear in the market, but the traditional Chinese medicine formulas still have slow effect, weak bactericidal effect and insignificant effect of promoting wound healing in the use process, and obvious hard scab and scar can be formed on the wound after the traditional Chinese medicine formulas are used.
Disclosure of Invention
In view of the above, the invention provides a traditional Chinese medicine composition for promoting rapid wound healing and a preparation method thereof.
The technical scheme of the invention is realized as follows:
a traditional Chinese medicine composition for promoting rapid wound healing comprises the following raw materials in parts by weight: 20-35 parts of Japanese ampelopsis root, 8-10 parts of dodder seed, 18-26 parts of agrimony, 20-28 parts of macleaya cordata, 20-24 parts of pyrola herb, 20-26 parts of purslane, 14-18 parts of peppermint, 15-22 parts of Chinese angelica, 18-26 parts of pagodatree pod, 8-13 parts of white atractylodes rhizome, 10-18 parts of schizonepeta, 12-17 parts of astragalus root, 4-9 parts of liquorice, 7-13 parts of paniculate swallowwort root, 3-8 parts of sedum sarmentosum, 6-10 parts of asarum, 7-12 parts of dahurian angelica root, 5-10 parts of fructus xanthii, 5-11 parts of divaricate saposhnikovia root, 16-24 parts of weeping forsythiae capsule, 3-9 parts of cacumen biotae, 1-7 parts of cortex rotundae, 7-12 parts of rhizoma drynariae, 10-18 parts of rhizoma bletillae, 6-9 parts of spina gleditsiae, 8-14 parts of Chinese gall, 3-5 parts of tortoise plastron, 2-8 parts of barbed skullcap herb, 4-10 parts of lotus root node, 3-7 parts of cuttlebone, 2-4 parts of cortex dictamni, 2-4 parts of pericarpium zanthoxyli and 1-6 parts of pricklyash.
Further, the traditional Chinese medicine composition for promoting the rapid healing of wounds comprises the following raw materials in parts by weight: 20 parts of Japanese ampelopsis root, 10 parts of semen cuscutae, 20 parts of agrimony, 20 parts of macleaya cordata, 22 parts of pyrola, 25 parts of purslane, 16 parts of mint, 20 parts of angelica sinensis, 18 parts of sophora fruit, 12 parts of white atractylodes rhizome, 10 parts of schizonepeta, 15 parts of astragalus root, 8 parts of liquorice, 12 parts of paniculate swallowwort root, 6 parts of stringy stonecrop herb, 8 parts of asarum herb, 12 parts of dahurian angelica root, 10 parts of cocklebur fruit, 10 parts of divaricate saposhnikovia root, 18 parts of weeping forsythia, 5 parts of biota orientalis, 5 parts of holly bark, 9 parts of muskmelon root, 16 parts of drynaria rhizome, 26 parts of bletilla, 8 parts of spina gleditsiae, 12 parts of gallnut, 5 parts of tortoise plastron, 4 parts of barbed skullcap herb, 10 parts of lotus root node, 7 parts of cuttlebone, 3 parts of ditsia bark and 5 parts of pricklyash.
The preparation method of the traditional Chinese medicine composition for promoting the rapid healing of wounds comprises the following steps:
step 1, crushing and sieving Japanese ampelopsis root, peppermint, schizonepeta, asarum herb, divaricate saposhnikovia root and Chinese prickly ash to obtain mixed powder A, and adding CO into the mixed powder A 2 Extracting in a supercritical extraction tank, and evaporating the extraction solvent from the extraction liquid by an evaporation system to obtain a composite extraction liquid;
step 2, crushing and sieving semen cuscutae, agrimony, macleaya cordata, purslane, chinese angelica, sophora fruit, white paeony root, angelica dahurica, fructus forsythiae, rhizoma drynariae and cortex dictamni to obtain mixed powder B, adding the mixed powder B into an aqueous solution of fruit acid to perform high-pressure impregnation, then performing ultrasonic extraction for 2-3 times to obtain a composite extract B, then adding tortoise plastron into the composite extract B to perform ultrasonic extraction for 2-3 times, merging the extracting solutions, and concentrating to obtain a composite extract C;
step 3, crushing herba pyrolae, astragalus membranaceus, liquorice, paniculate swallowwort root, sedum sarmentosum, fructus xanthii, cacumen biotae, cortex rotundae, radix soil, bletilla striata, spina gleditsiae, gallnut, barbed skullcap herb and lotus node, sieving to obtain mixed powder D, uniformly mixing the mixed powder D with a methanol-ethanol aqueous solution, performing ultrasonic extraction, repeating for 1-2 times, mixing the extracts, adding cuttlebone, uniformly mixing, and concentrating to obtain a compound extract D;
and 4, uniformly stirring and mixing the composite extract obtained in the step 1, the composite extract C obtained in the step 2 and the composite extract obtained in the step 3 to obtain the target traditional Chinese medicine composition.
Further, in the step 1, the CO 2 Supercritical extracted CO 2 The flow is 20-30L/h, the extraction temperature is 35-50 ℃, the extraction pressure is 7.5-8.0 MPa, and the extraction time is 50-90 min.
Further, in the step 2, the mass concentration of the aqueous solution of fruit acid is 2.5-5.0%; the fruit acid is one or more of lactic acid, malic acid, tartaric acid and citric acid.
In the step 2, the power of ultrasonic extraction is 90-120W, the temperature is 40-60 ℃, the ultrasonic intermittent time is 5S, and the total ultrasonic time is 25-30 min.
Further, in the step 3, the preparation method of the methanol-ethanol aqueous solution comprises the following steps: and placing the methanol and the ethanol into water according to the mass ratio of 1:2-4:12-20, and stirring and uniformly mixing to obtain the methanol-ethanol aqueous solution.
Furthermore, the traditional Chinese medicine composition is a liquid preparation or a solid ointment preparation.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine composition disclosed by the invention is reasonable in proportion, good in stability and strong in sterilization capability, can effectively resist pathogenic microorganisms, effectively prevent wound infection, promote wound cell regeneration, accelerate wound healing and reduce wound scar.
2. According to the invention, the Japanese ampelopsis root, the Chinese dodder seed, the agrimony, the macleaya cordata, the pyrola herb, the pagodatree pod, the astragalus root, the weeping forsythia, the ground beetle root, the spina gleditsiae and the tortoise plastron are used in a combined way, so that the regeneration of wound tissue cells can be effectively promoted, the wound crusting and falling off can be accelerated, the rapid healing of the wound can be promoted, and the stable hemostatic, analgesic and bactericidal effects can be effectively achieved under the combined action under the action of purslane, chinese angelica, biota oriental arborvitae, the ground beetle root, the bletilla striata, the barbed skullcap herb, the lotus rhizome node, the cuttlebone, the dittany bark, the pricklyash, the liquorice and the like, the wound inflammation can be prevented, and the wound healing can be promoted.
3. The traditional Chinese medicine composition provided by the invention has the advantages that the active components are stable in the preparation process, active substances in the traditional Chinese medicine composition can be effectively reserved and enriched, the extraction efficiency is high, the activity is good, the effect can be quickly achieved in the subsequent use process, and the wound healing is promoted.
4. The invention adopts CO in the preparation process 2 The components such as ampelopsis japonica, peppermint, schizonepeta, asarum and the like are extracted by supercritical extraction, so that active substances mainly containing volatile oil as active components can be effectively reserved; by adopting the effects of high-pressure impregnation and ultrasonic dispersion of the extracting solution of the fruit acid solution, active substances of components such as semen cuscutae, agrimony, macleaya cordata, purslane and the like can be fully dissolved out in the fruit acid solution, so that the extraction rate is improved, the active substances of the components can be effectively protected, the using effect of the composition is improved, and the wound healing is promoted; the active substances of the herba pyrolae, the astragalus, the liquorice, the paniculate swallowwort root, the stringy stonecrop herb and the like can be extracted by adopting a methanol-ethanol aqueous solution, and the active substances can be better reserved.
Detailed Description
In order to better understand the technical content of the present invention, the following provides specific examples to further illustrate the present invention.
The experimental methods used in the embodiment of the invention are conventional methods unless otherwise specified.
Materials, reagents, and the like used in the examples of the present invention are commercially available unless otherwise specified.
Example 1
The traditional Chinese medicine composition for promoting rapid wound healing comprises the following raw materials in parts by weight: 20 parts of Japanese ampelopsis root, 8 parts of dodder seed, 18 parts of agrimony, 20 parts of macleaya cordata, 20-parts of pyrola herb, 20 parts of purslane, 14 parts of peppermint, 15 parts of angelica, 18 parts of sophora fruit, 8 parts of white atractylodes rhizome, 10 parts of schizonepeta, 12 parts of astragalus root, 4 parts of liquorice, 7 parts of paniculate swallowwort root, 3 parts of stringy stonecrop herb, 6 parts of asarum herb, 7 parts of dahurian angelica root, 5 parts of cocklebur fruit, 5 parts of divaricate saposhnikovia root, 16 parts of weeping forsythia, 3 parts of biota orientalis, 1 part of holly bark, 7 parts of muskmelon root, 10 parts of drynaria rhizome, 23 parts of bletilla, 6 parts of spina gleditsiae, 8 parts of gallnut, 3 parts of tortoise plastron, 2 parts of barbed skullcap herb, 4 parts of lotus root node, 3 parts of cuttlebone, 2 parts of ditsia bark and 1 part of pricklyash.
Example 2
The traditional Chinese medicine composition for promoting rapid wound healing comprises the following raw materials in parts by weight: 35 parts of Japanese ampelopsis root, 10 parts of semen cuscutae, 26 parts of agrimony, 28 parts of macleaya cordata, 24 parts of pyrola, 26 parts of purslane, 18 parts of mint, 22 parts of angelica, 26 parts of sophora fruit, 13 parts of white atractylodes rhizome, 18 parts of schizonepeta, 17 parts of astragalus root, 9 parts of liquorice, 13 parts of paniculate swallowwort root, 8 parts of stringy stonecrop herb, 10 parts of asarum herb, 12 parts of dahurian angelica root, 10 parts of cocklebur fruit, 11 parts of divaricate saposhnikovia root, 24 parts of weeping forsythia, 9 parts of biota orientalis, 7 parts of holly bark, 12 parts of muskmelon root, 18 parts of drynaria rhizome, 32 parts of hyacinth bletilla, 9 parts of spina gleditsia, 14 parts of gallnut, 5 parts of tortoise plastron, 8 parts of barbed skullcap herb, 10 parts of lotus root node, 7 parts of cuttlebone, 4 parts of ditsia bark and 6 parts of pricklyash.
Example 3
The traditional Chinese medicine composition for promoting rapid wound healing comprises the following raw materials in parts by weight: 20 parts of Japanese ampelopsis root, 10 parts of semen cuscutae, 20 parts of agrimony, 20 parts of macleaya cordata, 22 parts of pyrola, 25 parts of purslane, 16 parts of mint, 20 parts of angelica sinensis, 18 parts of sophora fruit, 12 parts of white atractylodes rhizome, 10 parts of schizonepeta, 15 parts of astragalus root, 8 parts of liquorice, 12 parts of paniculate swallowwort root, 6 parts of stringy stonecrop herb, 8 parts of asarum herb, 12 parts of dahurian angelica root, 10 parts of cocklebur fruit, 10 parts of divaricate saposhnikovia root, 18 parts of weeping forsythia, 5 parts of biota orientalis, 5 parts of holly bark, 9 parts of muskmelon root, 16 parts of drynaria rhizome, 26 parts of bletilla, 8 parts of spina gleditsiae, 12 parts of gallnut, 5 parts of tortoise plastron, 4 parts of barbed skullcap herb, 10 parts of lotus root node, 7 parts of cuttlebone, 3 parts of ditsia bark and 5 parts of pricklyash.
The traditional Chinese medicine composition and the preparation method thereof in examples 1-3 comprise the following steps:
step 1, crushing and sieving Japanese ampelopsis root, peppermint, schizonepeta, asarum herb, divaricate saposhnikovia root and Chinese prickly ash to obtain mixed powder A, and adding CO into the mixed powder A 2 CO in supercritical extraction tank 2 Extracting for 60min at the flow rate of 20L/h and the temperature of 40 ℃ and the pressure of 7.5MPa, and evaporating the extraction solvent from the extraction liquid by an evaporation system to obtain a composite extraction liquid;
step 2, crushing and sieving semen cuscutae, agrimony, macleaya cordata, purslane, chinese angelica, sophora fruit, white paeony root, angelica dahurica, fructus forsythiae, rhizoma drynariae and cortex dictamni to obtain mixed powder B, and adding the mixed powder B into a mixture of malic acid and citric acid according to the mass ratio of 1:2, performing high-pressure impregnation in an aqueous solution of fruit acid with the mass concentration of 5.0%, performing ultrasonic extraction for 30min at the power of 120W and the temperature of 50 ℃ for 5S in an ultrasonic intermittent time, repeating for 2 times to obtain a compound extract B, adding tortoise plastron into the compound extract B, performing ultrasonic extraction for 25min at the power of 90W and the temperature of 45 ℃ for 5S in an ultrasonic intermittent time, repeating for 3 times, combining the extracts, and concentrating to obtain a compound extract C;
step 3, crushing herba pyrolae, astragalus membranaceus, liquorice, paniculate swallowwort root, sedum sarmentosum, fructus xanthii, cacumen biotae, cortex rotundae, rhizoma dioscoreae, bletilla striata, spina gleditsiae, gallnut, barbed skullcap herb and lotus node, sieving to obtain mixed powder D, uniformly mixing the mixed powder D with a methanol-ethanol aqueous solution prepared by putting methanol and ethanol into water according to a mass ratio of 1:3:15, performing ultrasonic extraction for 25min at a power of 100W at 50 ℃ for 5S at an ultrasonic intermittent time, repeating for 2 times, mixing the extracting solutions, adding cuttlebone, uniformly mixing, and concentrating to obtain a compound extract D;
and 4, uniformly stirring and mixing the composite extract obtained in the step 1, the composite extract C obtained in the step 2 and the composite extract obtained in the step 3, and concentrating to obtain the traditional Chinese medicine ointment preparation.
Comparative example 1
In comparison with example 3, the present comparative example does not contain semen Cuscutae, herba Agrimoniae, herba Macleayae Cordatae, fructus Sophorae, and carapax et Plastrum Testudinis. The preparation process is as follows:
step 1, crushing and sieving Japanese ampelopsis root, peppermint, schizonepeta, asarum herb, divaricate saposhnikovia root and Chinese prickly ash to obtain mixed powder A, and adding CO into the mixed powder A 2 CO in supercritical extraction tank 2 Extracting for 60min at the flow rate of 20L/h and the temperature of 40 ℃ and the pressure of 7.5MPa, and evaporating the extraction solvent from the extraction liquid by an evaporation system to obtain a composite extraction liquid;
step 2, crushing purslane, chinese angelica, white paeony root, angelica dahurica, weeping forsythia, rhizoma drynariae and cortex dictamni, sieving to obtain mixed powder B, and adding malic acid and citric acid into the mixed powder B according to the mass ratio of 1:2, carrying out high-pressure impregnation in an aqueous solution of fruit acid with the mass concentration of 5.0%, then carrying out ultrasonic extraction for 30min at the power of 120W and the temperature of 50 ℃ for 5S in an ultrasonic intermittent time, repeating for 2 times to obtain a compound extract B, merging the extract, and concentrating to obtain a compound extract C;
step 3, crushing herba pyrolae, astragalus membranaceus, liquorice, paniculate swallowwort root, sedum sarmentosum, fructus xanthii, cacumen biotae, cortex rotundae, rhizoma dioscoreae, bletilla striata, spina gleditsiae, gallnut, barbed skullcap herb and lotus node, sieving to obtain mixed powder D, uniformly mixing the mixed powder D with a methanol-ethanol aqueous solution prepared by putting methanol and ethanol into water according to a mass ratio of 1:3:15, performing ultrasonic extraction for 25min at a power of 100W at 50 ℃ for 5S at an ultrasonic intermittent time, repeating for 2 times, mixing the extracting solutions, adding cuttlebone, uniformly mixing, and concentrating to obtain a compound extract D;
and 4, uniformly stirring and mixing the composite extract obtained in the step 1, the composite extract C obtained in the step 2 and the composite extract obtained in the step 3, and concentrating to obtain the traditional Chinese medicine ointment preparation.
Comparative example 2
Compared with the example 3, the comparative example does not contain components of muskmelon root, biota orientalis, barbed skullcap herb, lotus node and cuttlebone, and the preparation process is as follows:
step 1, pulverizing radix Ampelopsis, herba Menthae, herba Schizonepetae, herba asari, radix Saposhnikoviae and fructus ZanthoxyliSieving to obtain mixed powder A, adding CO into the mixed powder A 2 CO in supercritical extraction tank 2 Extracting for 60min at the flow rate of 20L/h and the temperature of 40 ℃ and the pressure of 7.5MPa, and evaporating the extraction solvent from the extraction liquid by an evaporation system to obtain a composite extraction liquid;
step 2, crushing and sieving semen cuscutae, agrimony, macleaya cordata, purslane, chinese angelica, sophora fruit, white paeony root, angelica dahurica, fructus forsythiae, rhizoma drynariae and cortex dictamni to obtain mixed powder B, and adding the mixed powder B into a mixture of malic acid and citric acid according to the mass ratio of 1:2, performing high-pressure impregnation in an aqueous solution of fruit acid with the mass concentration of 5.0%, performing ultrasonic extraction for 30min at the power of 120W and the temperature of 50 ℃ for 5S in an ultrasonic intermittent time, repeating for 2 times to obtain a compound extract B, adding tortoise plastron into the compound extract B, performing ultrasonic extraction for 25min at the power of 90W and the temperature of 45 ℃ for 5S in an ultrasonic intermittent time, repeating for 3 times, combining the extracts, and concentrating to obtain a compound extract C;
step 3, crushing herba pyrolae, astragalus membranaceus, liquorice, paniculate swallowwort root, sedum sarmentosum, fructus xanthii, cortex rotundae, bletilla striata, spina gleditsiae and gallnut, sieving to obtain mixed powder D, uniformly mixing the mixed powder D with a methanol-ethanol aqueous solution prepared by putting methanol and ethanol into water according to a mass ratio of 1:3:15, performing ultrasonic extraction for 25min at a power of 100W at 50 ℃ for 5S in an ultrasonic intermittent time, repeating for 2 times, merging the extracting solutions, and concentrating to obtain a compound extract D;
and 4, uniformly stirring and mixing the composite extract obtained in the step 1, the composite extract C obtained in the step 2 and the composite extract obtained in the step 3, and concentrating to obtain the traditional Chinese medicine ointment preparation.
Comparative example 3
The preparation method of the traditional Chinese medicine composition of the comparative example is different from that of the example 3, and the specific preparation steps are as follows:
radix Ampelopsis, semen Cuscutae, agrimonia, herba Macleayae Cordatae, herba Hedyotidis Diffusae, herba Portulacae, herba Menthae, radix Angelicae sinensis, fructus Sophorae, fructus Chebulae, herba Schizonepetae, radix astragali, glycyrrhrizae radix, radix Cynanchi Paniculati, herba Sedi, herba asari, radix Angelicae Dahuricae, fructus Xanthii, radix Saposhnikoviae, fructus forsythiae, folium Platycladi, cortex Ilicis Rotundae, radix Trichosanthis, rhizoma Drynariae, rhizoma Bletillae, spina Gleditsiae, galla chinensis, carapax et Plastrum Testudinis, herba Scutellariae Barbatae, nodus Nelumbinis Rhizomatis, os Sepiae, cortex Dictamni Radicis, and fructus Zanthoxyli, sieving to obtain mixed powder, adding the mixed powder into 20% ethanol solution, performing ultrasonic extraction at power of 100deg.C for 5S for 25min, repeating for 2 times, mixing the extractive solutions, concentrating to obtain Chinese medicinal ointment.
Test conditions:
1. antibacterial test
The traditional Chinese medicine ointment preparations prepared in examples 1 to 3 and comparative examples 1 to 3 of the invention are used for antibacterial condition tests.
(1) Preparing a test bacterial liquid sample: the single bacterial colony of staphylococcus aureus and pseudomonas aeruginosa is respectively picked up and evenly mixed with 10mL of sterile water to prepare the bacterial colony with the concentration of 1 multiplied by 10 6 CFU/mL bacterial liquid sample.
(2) Preparation of test samples: the Chinese medicinal ointment preparations of examples 1 to 3 and comparative examples 1 to 3 were added to 10mL of sterile water, respectively, and mixed well, and then diluted with water to give test samples having a concentration of 0.01 g/mL.
(3) The test process comprises the following steps: taking 80 culture dishes, equally dividing the culture dishes into 8 groups, 10 groups each, respectively corresponding to the groups of examples 1-3 and comparative examples 1-3 and blank groups, pouring PDA culture medium into the culture dishes under aseptic condition, after the culture medium is solidified, respectively inoculating staphylococcus aureus and pseudomonas aeruginosa bacteria liquid samples into the culture dishes by adopting an aseptic inoculating loop under aseptic condition, respectively inoculating 5 bacteria liquids in each group, then dripping 200 mu L of traditional Chinese medicine ointment preparation test sample into the corresponding culture dishes, dripping 200 mu L of physiological saline into the blank groups, culturing for 24 hours at 37 ℃, observing a bacteriostasis ring, measuring the diameter of the bacteriostasis ring by using a vernier caliper, recording test data of each group, and taking an average value of test results of each group.
2. Healing condition test
The traditional Chinese medicine ointment preparations prepared in the examples 1-3 and the comparative examples 1-3 are used for rat experiments to determine the effect of promoting wound healing. Taking 48 healthy male and female half rats, dehairing at the same position on the back of the rats, and performing skin incision on the back by adopting a surgical incision method to form a wound surface of 2X 2cm, wherein the wound surface is randomly divided into 6 test groups of 8 rats. The traditional Chinese medicine ointment preparation prepared in the embodiment 1-3 of the invention is respectively used for smearing in the experiment 1-3, 1 time a day, the traditional Chinese medicine ointment preparation prepared in the comparative example 1-3 is respectively used for smearing in the experiment 4-6, 1 time a day, continuous observation is carried out for 8 days, and wound healing conditions of rats are recorded after 8 days.
Healing rate = S 1 /S 0 X 100%, where S 1 For healing area, S 0 Is the area of the original surface.
Table 1 test conditions of the Chinese medicinal composition
The results show that the traditional Chinese medicine composition has good effects in inhibiting staphylococcus aureus, pseudomonas aeruginosa and the like, and can effectively promote wound healing. In the aspects of not adding the components of semen cuscutae, agrimony, macleaya cordata, sophora fruit, tortoise plastron, muskmelon root, arborvitae twig, barbed skullcap herb, lotus node and cuttlebone and the preparation method which are different from the invention, the diameter of the antibacterial circle of the comparative example 1-3 on staphylococcus aureus is 14.46-18.37 mm, the diameter of the antibacterial circle on pseudomonas aeruginosa is 15.29-19.21 mm, and the healing rate of the comparative example 1-3 is 90.27-93.45%. The effect is poor. The traditional Chinese medicine composition has the synergistic effect under the synergistic effect of the components, enhances the antibacterial effect of the ointment preparation and can effectively promote wound healing.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (3)
1. The traditional Chinese medicine composition for promoting rapid wound healing is characterized by being prepared from the following raw materials in parts by weight: 20-35 parts of Japanese ampelopsis root, 8-10 parts of semen cuscutae, 18-26 parts of agrimony, 20-28 parts of macleaya cordata, 20-24 parts of pyrola, 20-26 parts of purslane, 14-18 parts of peppermint, 15-22 parts of Chinese angelica, 18-26 parts of pagodatree pod, 8-13 parts of fructus kochiae, 10-18 parts of schizonepeta, 12-17 parts of astragalus root, 4-9 parts of liquorice, 7-13 parts of paniculate swallowwort root, 3-8 parts of sedum sarmentosum, 6-10 parts of asarum, 7-12 parts of dahurian angelica root, 5-10 parts of fructus xanthii, 5-11 parts of divaricate saposhnikovia root, 16-24 parts of weeping forsythia, 3-9 parts of cacumen biotae, 1-7 parts of cortex rotundae, 7-12 parts of rhizoma bletillae, 10-18 parts of rhizoma bletillae, 6-9 parts of spina gleditsiae, 8-14 parts of Chinese gall, 3-5 parts of tortoise plastron, 2-8 parts of barbed skullcap herb, 4-10 parts of lotus root, 3-7 parts of cuttlebone, 2-4 parts of cortex dictamni, 2-4 parts of cortex zanthoxyli, 1-6 parts of pericarpium zanthoxyli;
the preparation method of the traditional Chinese medicine composition for promoting the rapid healing of wounds comprises the following steps:
step 1, crushing and sieving Japanese ampelopsis root, peppermint, schizonepeta, asarum herb, divaricate saposhnikovia root and Chinese prickly ash to obtain mixed powder A, and adding CO into the mixed powder A 2 CO in supercritical extraction tank 2 Extracting for 50-90 min under the conditions of the flow rate of 20-30L/h, the extraction temperature of 35-50 ℃ and the extraction pressure of 7.5-8.0 MPa, and evaporating the extraction solvent from the extraction liquid by an evaporation system to obtain a composite extraction liquid;
step 2, crushing and sieving semen cuscutae, agrimony, macleaya cordata, purslane, chinese angelica, sophora fruit, white paeony root, angelica dahurica, fructus forsythiae, rhizoma drynariae and cortex dictamni to obtain mixed powder B, adding the mixed powder B into an aqueous solution of fruit acid to perform high-pressure impregnation, then performing ultrasonic extraction for 2-3 times to obtain a composite extract B, then adding tortoise plastron into the composite extract B to perform ultrasonic extraction for 2-3 times, merging the extracting solutions, and concentrating to obtain a composite extract C; the power of ultrasonic extraction is 90-120W, the temperature is 40-60 ℃, the ultrasonic intermittent time is 5S, and the total ultrasonic time is 25-30 min; the mass concentration of the aqueous solution of the fruit acid is 2.5-5.0%; the fruit acid is one or the combination of more than two groups of lactic acid, malic acid, tartaric acid and citric acid;
step 3, crushing herba pyrolae, astragalus membranaceus, liquorice, paniculate swallowwort root, sedum sarmentosum, fructus xanthii, cacumen biotae, cortex rotundae, radix soil, bletilla striata, spina gleditsiae, gallnut, barbed skullcap herb and lotus node, sieving to obtain mixed powder D, uniformly mixing the mixed powder D with a methanol-ethanol aqueous solution, performing ultrasonic extraction, repeating for 1-2 times, mixing the extracts, adding cuttlebone, uniformly mixing, and concentrating to obtain a compound extract D; the preparation method of the methanol-ethanol aqueous solution comprises the following steps: placing methanol and ethanol in water according to a mass ratio of 1:2-4:12-20, and stirring and uniformly mixing to obtain a methanol-ethanol water solution;
and 4, uniformly stirring and mixing the composite extract obtained in the step 1, the composite extract C obtained in the step 2 and the composite extract obtained in the step 3 to obtain the target traditional Chinese medicine composition.
2. The traditional Chinese medicine composition for promoting rapid wound healing according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 20 parts of Japanese ampelopsis root, 10 parts of semen cuscutae, 20 parts of agrimony, 20 parts of macleaya cordata, 22 parts of pyrola, 25 parts of purslane, 16 parts of mint, 20 parts of angelica sinensis, 18 parts of sophora fruit, 12 parts of white atractylodes rhizome, 10 parts of schizonepeta, 15 parts of astragalus root, 8 parts of liquorice, 12 parts of paniculate swallowwort root, 6 parts of stringy stonecrop herb, 8 parts of asarum herb, 12 parts of dahurian angelica root, 10 parts of cocklebur fruit, 10 parts of divaricate saposhnikovia root, 18 parts of weeping forsythia, 5 parts of biota orientalis, 5 parts of holly bark, 9 parts of muskmelon root, 16 parts of rhizoma drynariae, 26 parts of bletilla, 8 parts of spina gleditsiae, 12 parts of gallnut, 5 parts of tortoise plastron, 4 parts of barbed skullcap herb, 10 parts of lotus root node, 7 parts of cuttlebone, 3 parts of ditsia bark and 5 parts of pricklyash.
3. The traditional Chinese medicine composition for promoting rapid wound healing according to any one of claims 1-2, wherein the traditional Chinese medicine composition is a liquid preparation or a solid ointment preparation.
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