CN116712506A - Traditional Chinese medicine composition for soothing nerves and improving intelligence as well as preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for soothing nerves and improving intelligence as well as preparation method and application thereof Download PDF

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Publication number
CN116712506A
CN116712506A CN202310776662.7A CN202310776662A CN116712506A CN 116712506 A CN116712506 A CN 116712506A CN 202310776662 A CN202310776662 A CN 202310776662A CN 116712506 A CN116712506 A CN 116712506A
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parts
chinese medicine
traditional chinese
medicine composition
chrysanthemum
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肖伟
马静雯
王振东
王琳
苏文净
周荣翔
柏伟荣
朱孟楠
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Jiangsu Kanion Pharmaceutical Co Ltd
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Jiangsu Kanion Pharmaceutical Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/06—Fungi, e.g. yeasts
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A61K36/8969—Polygonatum (Solomon's seal)
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Abstract

The invention provides a traditional Chinese medicine composition for soothing nerves and improving intelligence, and a preparation method and application thereof. The composition has the effects of improving memory, soothing nerves and nourishing brain, and comprises the following components in parts by weight: 1 to 100 parts of poria cocos, 1 to 100 parts of Chinese yam, 1 to 50 parts of wild jujube seed, 1 to 50 parts of medlar, 1 to 50 parts of chrysanthemum, 1 to 50 parts of rhizoma polygonati, 1 to 20 parts of longan pulp, 0.01 to 0.1 part of walnut peptide, 0.01 to 1 part of phosphatidylserine, 0.01 to 1 part of N-acetylneuraminic acid and 0.1 to 5 parts of vitamin C. The composition has the effects of soothing the nerves, improving intelligence, nourishing yin and blood, nourishing heart and tonifying kidney, tonifying qi and generating blood, improving memory and improving sleep.

Description

Traditional Chinese medicine composition for soothing nerves and improving intelligence as well as preparation method and application thereof
Technical Field
The invention relates to the technical field of medicines, foods and health products, in particular to a composition for improving memory, soothing nerves and nourishing brain and a preparation method thereof.
Background
Memory is an important cognitive function, and comprises 4 processes of memorizing, maintaining, cognizing and recall, while the hypomnesis affects the daily work and learning of people, and serious safety accidents are caused, so that serious damage is brought to other people and society. There are many causes of memory decline, mainly including pressure rise, body aging, metabolic syndrome and risk factors. The formation of memory is closely related to the synaptic plasticity of neurons, and one of the main functions of sleep is to recover the synaptic plasticity of brain and promote the formation of new memory, so that the improvement of sleep quality is in important connection with the improvement of memory and brain cognitive ability. The investigation result shows that the probability of insomnia accompanied with hypomnesis is as high as 86.81%.
In recent years, with the continuous acceleration of the current life rhythm, the night activity time of children and teenagers is obviously increased, the sleep time is obviously reduced, and the phenomenon of sleep deprivation occurs to different degrees. Sleep deprivation refers to failure to meet normal sleep due to environmental and self causes, manifesting as reduced sleep or sleep continuity interruption, and long-term sleep deprivation can easily lead to reduced performance, inattention, impaired memory, and impaired learning. The phenomenon of insufficient sleep time, insomnia and the like caused by delayed sleeping of the teenagers after sleeping is more common. Under heavy academic pressures, the incidence of childhood adolescence problems continues to rise. The children and the young people are in the key period of growth and development, face high-pressure and high-strength study, use more brains, often feel that the capacity of the brains is not enough, and fatigue or the conditions of memory decline, concentration lack, poor sleep and the like occur, so that the effects of improving the memory, improving the intelligence and tonifying the brain, soothing the nerves and tonifying the brain are the health care work which can not be ignored by parents, and are the focus of attention of the society at present. The problems of insufficient sleep, sleep disorder and the like seem to be potential influencing factors of intelligence and learning ability. Under the background, the inventor intends to provide a tranquillizing and intelligence-improving composition with the functions of improving memory, tranquillizing and nourishing brain and a preparation method thereof.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition with the effects of improving memory, soothing nerves and nourishing brain and a preparation process thereof, and the specific technical scheme is as follows:
firstly, the invention provides a traditional Chinese medicine composition, which comprises the following components in percentage by weight: 1-100 parts of poria cocos, 1-100 parts of Chinese yam, 1-50 parts of spina date seed, 1-50 parts of medlar, 1-50 parts of chrysanthemum, 1-50 parts of rhizoma polygonati and 1-20 parts of longan pulp. The composition of the present invention may be directly pulverized, or may be an extract obtained by conventional means in the art, etc. The traditional Chinese medicine used in the composition of the invention can also be used in a mode of directly grinding into powder, extract or other processing forms.
Preferably, the Chinese medicinal composition comprises: 1 to 50 parts of poria cocos, 1 to 50 parts of Chinese yam, 1 to 30 parts of spina date seed, 1 to 30 parts of medlar, 1 to 30 parts of chrysanthemum, 1 to 30 parts of rhizoma polygonati and 1 to 15 parts of longan pulp.
Preferably, the Chinese medicinal composition comprises: 10-30 parts of poria cocos, 10-30 parts of Chinese yam, 5-20 parts of spina date seed, 5-20 parts of medlar, 5-20 parts of chrysanthemum, 5-20 parts of rhizoma polygonati and 2-10 parts of longan pulp.
Preferably, the Chinese medicinal composition comprises: 10-20 parts of poria cocos, 10-20 parts of Chinese yam, 5-15 parts of spina date seed, 5-15 parts of medlar, 5-15 parts of chrysanthemum, 5-15 parts of rhizoma polygonati and 2-8 parts of longan pulp.
Preferably, the Chinese medicinal composition comprises: 12-18 parts of poria cocos, 12-18 parts of Chinese yam, 7-13 parts of spina date seed, 7-13 parts of medlar, 7-13 parts of chrysanthemum, 7-13 parts of rhizoma polygonati and 4-6 parts of longan pulp.
Preferably, the Chinese medicinal composition comprises: 13-17 parts of poria cocos, 13-17 parts of Chinese yam, 8-12 parts of spina date seed, 8-12 parts of medlar, 8-12 parts of chrysanthemum, 8-12 parts of rhizoma polygonati and 3-7 parts of longan pulp.
Preferably, the Chinese medicinal composition comprises: 10-15 parts of poria cocos, 10-15 parts of Chinese yam, 5-10 parts of spina date seed, 5-10 parts of medlar, 5-10 parts of chrysanthemum, 5-10 parts of rhizoma polygonati and 2-5 parts of longan pulp.
Most preferably, the Chinese medicinal composition comprises: 15 parts of poria cocos, 15 parts of Chinese yam, 10 parts of spina date seed, 10 parts of medlar, 10 parts of chrysanthemum, 10 parts of rhizoma polygonati and 5 parts of longan pulp.
Further, the composition also comprises 0.01 to 0.1 part of walnut peptide, 0.01 to 1 part of phosphatidylserine, 0.01 to 1 part of N-acetylneuraminic acid and 0.1 to 5 parts of vitamin C. Preferably, the walnut peptide is 0.01-0.05 part, the phosphatidylserine is 0.01-0.2 part, the N-acetylneuraminic acid is 0.01-0.2 part, and the vitamin C is 0.1-1.2 part. Preferably, the walnut peptide is 0.03-0.05 part, the phosphatidylserine is 0.2-0.3 part, the N-acetylneuraminic acid is 0.2-0.3 part, and the vitamin C is 1-1.2 part. Most preferably, the walnut peptide is 0.05 part, the phosphatidylserine is 0.2 part, the N-acetylneuraminic acid is 0.2 part and the vitamin C is 1.2 part.
The invention also provides application of the composition in preparing medicines, health products or foods for improving memory, soothing nerves and nourishing brain or improving insomnia.
The insomnia can be heart-kidney disharmony type insomnia.
The composition of the invention can be used for tranquillizing, developing intelligence, nourishing yin, nourishing blood, nourishing heart, tonifying kidney, tonifying qi, promoting blood production, improving memory, improving sleep and the like.
In particular, the use may be in any manner that is beneficial for improving the corresponding symptoms of the patient, including treatment or prevention.
The invention also provides a medicine, food or health care product containing any one of the compositions.
Specifically, the medicine, food or health product is selected from hard capsule, tablet, granule, soft capsule, oral liquid, tabletting candy, gel candy, plant beverage, and solid beverage.
Further, the compound also comprises one or more auxiliary materials acceptable in pharmacy, health-care products or foods, wherein the auxiliary materials are selected from maltodextrin, corn starch, microcrystalline cellulose, silicon dioxide, magnesium stearate, sorbitol, erythritol, stevioside, sucralose, mogroside, gelatin, xanthan gum, carrageenan, fruit powder and fruit juice.
Another object of the present invention is to provide a method for preparing the above composition, specifically comprising the steps of:
(1) Weighing crude drugs of poria cocos, chinese yam, spina date seed, medlar, chrysanthemum, rhizoma polygonati and longan pulp according to parts, removing impurities, cleaning, adding 5-15 times of water, decocting and extracting for 1-3 times, and 0.5-3.0 h/time to obtain an extracting solution, mixing the extracting solutions, and filtering;
(2) Concentrating the extractive solution under reduced pressure to obtain extract with relative density of 1.10-1.15 (55+ -5deg.C).
The invention also aims to provide a preparation method of the medicine, food or health care product granules, which comprises the following steps:
(1) Weighing crude drugs of poria cocos, chinese yam, spina date seed, medlar, chrysanthemum, rhizoma polygonati and longan pulp according to parts, cleaning, adding 5-15 times of water, decocting and extracting for 1-3 times, and 0.5-3.0 h/time to obtain an extracting solution, mixing the extracting solutions, and filtering;
(2) Concentrating the extract under reduced pressure to obtain extract with relative density of 1.10-1.15 (55+ -5deg.C);
(3) Drying and pulverizing the above extract to obtain dry extract powder, adding Juglandis peptide, phosphatidylserine, N-acetylneuraminic acid, and vitamin C, mixing, adding pharmaceutically, health product or food acceptable adjuvants, and making into granule.
In the composition, the wild jujube seed and the poria cocos are used for strengthening the spleen and calming the heart, tranquilizing and nourishing the spirit, astringing qi and promoting the production of body fluid, and Gan Wenyuan meat is used for regulating qi and nourishing blood; rhizoma Dioscoreae has effects of invigorating kidney yin to arrest spontaneous emission, and rhizoma Polygonati has effects of invigorating deficiency to fill essence; fructus Lycii and flos Chrysanthemi have effects of invigorating kidney, promoting vital essence production, replenishing vital essence, improving eyesight, clearing heat, and removing pathogenic fire, and can be used for tonifying heart and kidney, regulating qi and blood, replenishing essence and improving intelligence. The Chinese herbal medicine with homology of medicine and food is safe and reliable, can be eaten after long-term body adjustment, has no toxic or side effect, has no medicine dependence, and is safe and effective after long-term eating. In addition, walnut peptide, phosphatidylserine, N-acetylneuraminic acid and vitamin C are also added, so that the efficacy of the composition is further improved.
Experiments show that the composition can increase body mass, restore circadian rhythm, smooth and glossy fur, improve memory and reduce CORT, CRH, ACTH level in serum of rats for insomnia rats with imbalance of heart and kidney. The composition prepared by the invention has the effects of soothing the nerves, improving intelligence, nourishing yin, nourishing blood, nourishing heart, tonifying kidney, tonifying qi, promoting blood production, improving memory and improving sleep.
The method provided by the invention has mature industrial operation technology, and all raw materials are food-grade and can be safely eaten; provides a brand new composition for improving memory, soothing nerves and nourishing brain and a preparation method thereof for the public.
Detailed Description
As stated above, the present invention aims to provide a traditional Chinese medicine composition, and a preparation method and application thereof. The following will specifically describe the contents of experimental examples.
The main raw materials used in the invention are as follows, poria cocos: dried sclerotium of Wolf, a fungus of the family Polyporaceae, tuckahoe, poria cocos (schw.); chinese yam: dried rhizome of Dioscorea opposita Dioscorea opposita Thunb of Dioscoreaceae is prepared by parching with bran (Tongshi 0213); semen Ziziphi Spinosae: the dried mature seed of Ziziphus jujuba Mill. Var. Spinosa (Bunge) Hu ex H.F.Chou of Rhamnaceae is selected from semen Ziziphi Spinosae (general rule 0213) after parching; wolfberry fruit: dried mature fruit of Lycium barbarum L. Of Solanaceae; and (3) chrysanthemum: dried head of chrysanthemum Chrysanthemum morifolium Ramat. Rhizoma polygonati: rhizoma Polygonati Polygonatum kingianum Coll et Hemsl, polygonatum sibiricum Red, or Polygonatum cyrtonema Hua dried rhizome of Polygonatum cyrtonema Sieb of Liliaceae, rhizoma Polygonati after steaming with wine (general rule 0213) is used; longan pulp: aril of the family Sapindaceae, longan Dimocarpus longan Lour; the walnut peptide powder is prepared from walnut as raw material, from Xinghui Tianli (Hangzhou) pharmaceutical industry Co., ltd, by controllable enzymolysis technique, refining, separating, purifying, drying and packaging; phosphatidylserine is purchased from Shaanxi Baichuan Kang Ze biotechnology Co., ltd, with 20 percent (7948-5) of specification, and can be prepared by taking soybean lecithin and L-serine as raw materials, adopting phospholipase conversion reaction, purifying and concentrating, purifying for the second time, drying and packaging; n-acetylneuraminic acid: the new food raw material has a molecular formula of C11H19NO9 and a molecular weight of 309.27, and is an amino monosaccharide with nine carbon skeleton. The invention is carried out according to the conventional conditions or the conditions suggested by manufacturers if the specific conditions are not noted, and the raw materials or auxiliary materials and the reagents or instruments are conventional products which can be obtained commercially if the manufacturers are not noted.
Example 1 Chinese herbal Compound Capsule
The formula comprises the following components: 10 parts of poria cocos, 30 parts of Chinese yam, 5 parts of spina date seed, 5 parts of medlar, 20 parts of chrysanthemum, 20 parts of rhizoma polygonati, 10 parts of longan pulp, 0.03 part of walnut peptide, 0.3 part of phosphatidylserine, 0.3 part of N-acetylneuraminic acid and 1.0 part of vitamin C
The preparation method of the traditional Chinese medicine composition capsule comprises the following steps:
adding 10 times of water after removing impurities and cleaning the medicinal materials, decocting and extracting for 2 times and 1 hour to obtain an extracting solution, combining the extracting solutions, filtering, concentrating the filtrate under reduced pressure to obtain a fluid extract with the relative density of 1.10-1.15 (55+/-5 ℃), spray-drying to obtain a fine powder dry extract, and adding the walnut peptide, the phosphatidylserine, the N-acetylneuraminic acid and the vitamin C into the fine powder dry extract, and uniformly mixing to obtain the traditional Chinese medicine composition. Adding certain auxiliary materials, spraying 90% ethanol to wet materials, placing into a swing granulator for wet granulation, and drying at 60 ℃; and (3) finishing the dried granules, and subpackaging into capsules to obtain the traditional Chinese medicine compound capsule.
Example 2 Chinese herbal Compound granule
The formula comprises the following components: 15 parts of poria cocos, 15 parts of Chinese yam, 10 parts of spina date seed, 10 parts of medlar, 10 parts of chrysanthemum, 10 parts of rhizoma polygonati, 5 parts of longan pulp, 0.05 part of walnut peptide, 0.2 part of phosphatidylserine, 0.2 part of N-acetylneuraminic acid and 1.2 parts of vitamin C.
The preparation method of the traditional Chinese medicine composition granule comprises the following steps:
adding 10 times of water after removing impurities and cleaning the medicinal materials, decocting and extracting for 2 times and 1 hour to obtain an extracting solution, combining the extracting solutions, filtering, concentrating the filtrate under reduced pressure to obtain a fluid extract with the relative density of 1.10-1.15 (55+/-5 ℃), spray-drying to obtain a fine powder dry extract, and adding the walnut peptide, the phosphatidylserine, the N-acetylneuraminic acid and the vitamin C into the fine powder dry extract, and uniformly mixing to obtain the traditional Chinese medicine composition. Adding certain maltodextrin, spraying 90% ethanol to wet material, granulating in a swing granulator, drying at 60deg.C, grading, packaging to obtain compound granule, packaging with aluminum plastic sealed bag, and storing in shade and dry place.
EXAMPLE 3 Effect of the inventive Chinese medicinal composition on weight, learning and memory ability and serum CORT, CRH, ACTH content of Insomnia rats with imbalance between heart and kidney
SPF grade is adopted in the experiment, SD male mice are used for constructing animal models, after the traditional Chinese medicine composition is administrated to model animals in a gastric lavage mode, the study memory capacity and the sleep state of each group of mice are evaluated by adopting Morris water maze experiment and serum Corticosterone (CORT), adrenocorticotropic hormone releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) content detection so as to clearly define the effects of the traditional Chinese medicine composition on tranquillization and intelligence improvement.
1. Experimental materials and methods
1.1 Experimental animal
SPF-grade male SD rats with initial body mass of 200+ -20 g. Before the experiment, the animals are adaptively fed for 5 days in a light and dark circulation environment for 12 hours at the temperature of 25+/-2 ℃ and the relative humidity of 50% -60%, and the animals can freely take water and eat during the experiment.
1.2 test drug
Traditional Chinese medicine composition prepared in example 2
1.2 Experimental modeling, grouping, and administration
Rats were randomly divided into a normal control group, a model group, an experimental low dose group (1.8 g crude drug/kg), an experimental medium dose group (3.6 g crude drug/kg), and an experimental high dose group (7.2 g crude drug/kg), 5 groups of 10 animals each. The rats in the model group and the experimental group are all subjected to different stimulation conditions of 1-14d, 1-2 types of stimulation are randomly arranged every day, and the method mainly comprises fasted food, water forbidden, ice water swimming at 4 ℃, tail clamping, tail shaking, 24h of wet padding, 45 degrees of mouse cage inclination, constraint stress, noise stimulation, flash stimulation, horizontal vibration, day-night inversion and the like, so that the rats are prevented from generating adaptability to external stimulation, the rats are started to be subjected to intraperitoneal injection of p-chlorophenylalanine (PCPA) suspension for 1 time/d, 3d are continuously carried out, the circadian rhythm of the rats is disappeared, the rats fall off, and the rats are low in sleep, are low in spirit and have withered and easily fallen hair, and the fact that the heart-kidney imbalance insomnia rat model is successfully copied is shown. Normal rats normally supplied feed and drinking water within days 1-14, did not receive any stimulus, and were given an equal volume of saline by intraperitoneal injection at 15-17 days. After successful molding, the normal control group and the model control group are respectively irrigated with corresponding medicines according to the weight of 1mL/100g distilled water, and the irrigated volume of 1mL/100g weight is administrated once daily.
1.3 Experimental index determination
1.3.1 rat body Mass measurement
The body mass of each rat was weighed before the start of the experiment and at day 7, 14, 17, 24 of the experiment, respectively.
1.3.2 evaluation of rat behaviours
The behavioral state (jumping, striking, lying, squinting), the activity level (slow, weakening, general, active), the insomnia state (east, tense, frightening, manic, agitation) and the mental state (listlessness, sleeping, normal, insanitation) of the hair skin (dull, general, smooth and bright) and the mental state (listlessness, sleeping, normal, insanitation) of the rats were observed, and the observation time of the rat state was 10 per day: 00-12:00.
1.3.3 test of learning memory Capacity of rats
On day 19 of the experiment, 4d pilot voyage test and 1d space exploration test were performed on each group of rats according to Morris water maze training test procedure. The positioning navigation test is that a pool is equally divided into 4 quadrants (an upper right quadrant, an upper left quadrant, a lower left quadrant and a lower right quadrant are respectively one to four quadrants), 1 platform is placed in the center position of a third quadrant, the platform is 2.5cm lower than the horizontal plane, the midpoint of each quadrant arc is selected as a fixed water inlet point of a rat, and the learning and memory capacity of the rat in a water maze is detected. The space exploration test was to remove the platform on day 23, place all experimental rats in water in the first quadrant facing the pool wall, record the number of times the rats traversed the original platform position within 120s and the swimming time in the third quadrant.
1.3.4 detection of CRH, ACTH, CORT levels in rat serum
After 2h of the last administration, 10% chloral hydrate was used for intraperitoneal injection for anesthesia, the abdominal aorta was taken for blood, after 1h of standing, the supernatant was taken after centrifugation at 3500rpm for 15min at 4 ℃. The levels of CRH, ACTH, CORT in the serum of each group of rats were measured by ELISA.
1.4 statistical analysis
Data processing was performed using SPSS 23.0 software, data expressed as x+ -s, comparison between two groups using two independent sample t-tests, and differences expressed as P <0.05 were statistically significant.
2. Experimental results
2.1 Effect on rat body Mass
As can be seen from Table 1, the model group showed a significant decrease in body mass (p < 0.01) compared to normal rats after 7d of stimulation with different conditions. After the end of the last dose, the mass of rats in the three experimental groups is obviously increased (p is less than 0.05 and p is less than 0.01) compared with that of rats in the model group, and the increase degree of the rats in the middle and high dose groups is higher than that of rats in the low dose group.
TABLE 1 influence of Chinese medicinal composition on the body quality of Insomnia rats with disharmony between heart and kidneyn＝10)
Note that: comparing # P <0.01 to the normal group; comparison with model group P <0.05, P <0.01
2.2 effects on general behaviours in rats
After the modeling is finished, compared with a normal group, the sleep time of the modeling rat is reduced, the hair is withered and easily falls off, the spirit is low, the reaction is slow, and the pathological manifestations are close to the symptoms of heart-kidney disharmony insomnia patients in clinical traditional Chinese medicine. Compared with a model group, the daily activities of rats in the experimental group are obviously reduced, the rats are tired and recumbent, the circadian rhythm begins to recover, and the fur is gradually smooth and glossy.
2.3 Effect on learning and memory Capacity of rats
As can be seen from table 2, the number of times the model rats crossed the original station was significantly reduced (P < 0.01) and the residence time in the third quadrant was significantly shortened (P < 0.05) compared to the normal group. Compared with the model group, the number of times of rats crossing the original platform and the residence time in the third quadrant are obviously increased (P <0.05 and P < 0.01), and the increase of the medium and high dose groups is more obvious.
TABLE 2 influence of Chinese medicinal composition on learning and memory ability of insomnia rats with imbalance of heart and kidneyn＝10)
Note that: comparing #P <0.05, #P <0.01 with the normal group; p <0.05, P <0.01 compared to model group.
2.4 Effect on CORT, CRH, ACTH levels in rat serum
As can be seen from table 3, the CORT, CRH, ACTH levels in the serum of rats in the model group were significantly elevated (P < 0.01) compared to the normal group; compared with the model group, the three experimental groups can reduce CORT, CRH, ACTH level (P <0.05, P < 0.01) in rat serum to different degrees, and the traditional Chinese medicine composition has better medium and high dose regulation effect.
TABLE 3 influence of Chinese medicinal composition on CORT, CRH, ACTH level in serum of Insomnia rat caused by imbalance of heart and kidneyn＝10)
Note that: comparing # P <0.01 to the normal group; p <0.05, P <0.01 compared to model group.
3. Summary of the experiment
PCPA is a specific inhibitor of 5-HT biosynthesis in the brain, and intraperitoneal injection of PCPA can lead animals to insomnia, and is a relatively common model at home and abroad; the model of the insomnia rat established by multi-factor co-stimulation can cause energy metabolism disorder, activity reduction and activation of hypothalamus-pituitary-adrenal axis (HPA axis) of the rat, shows more clinical symptoms which accord with insomnia caused by heart-kidney imbalance of traditional Chinese medicine, has high success rate, better reliability and stability, and is an ideal model for researching the efficacy and mechanism of the insomnia.
Insomnia is closely related to dysfunction of the HPA axis and neurotransmitter levels. 3 hormones secreted by the HPA axis: CORT, CRH, ACTH are all involved in sleep regulation. In stress conditions, amygdala is activated, resulting in an increase in activation of the HPA axis and secretion of CRH, and an increase in ACTH and CORT concentrations, resulting in a wakefulness effect. The research shows that under the insomnia state, the HPA axis activation can promote the synthesis and secretion of ACTH and CORT, and the levels of ACTH and CORT are increased normally, so that the brain cortex stress is improved, the arousal is increased, and the method is an important link for causing insomnia.
The research result of the invention shows that the circadian rhythm of the rat after molding is disappeared, the reaction is slow, the hair is withered, the HPA axis is enabled to be stimulated, and the CRH, ACTH and CORT levels are obviously increased. The circadian rhythm of the rats is recovered after the intervention of the traditional Chinese medicine composition provided by the invention, the fur becomes smooth and glossy, the hormone levels of serum HPA axes of the insomnia rats can be obviously reduced, the sleeping behavior of the insomnia rats is improved, and the regulation effect of the traditional Chinese medicine composition with medium and high doses is more obvious, so that the traditional Chinese medicine composition provided by the invention can be used for treating insomnia.
The research results show that the tested traditional Chinese medicine composition can also improve the learning and memory capacity of rats with insomnia caused by heart and kidney disharmony, reduce the CORT, CRH, ACTH level in serum, and has stronger regulation and control effects, thereby achieving the effect of improving sleep.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.

Claims (10)

1. The traditional Chinese medicine composition for soothing nerves and improving intelligence is characterized by comprising the following components in parts by weight:
1-100 parts of poria cocos, 1-100 parts of Chinese yam, 1-50 parts of spina date seed, 1-50 parts of medlar, 1-50 parts of chrysanthemum, 1-50 parts of rhizoma polygonati and 1-20 parts of longan pulp.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises:
10-30 parts of poria cocos, 10-30 parts of Chinese yam, 5-20 parts of spina date seed, 5-20 parts of medlar, 5-20 parts of chrysanthemum, 5-20 parts of rhizoma polygonati and 2-10 parts of longan pulp.
3. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises:
10-15 parts of poria cocos, 10-15 parts of Chinese yam, 5-10 parts of spina date seed, 5-10 parts of medlar, 5-10 parts of chrysanthemum, 5-10 parts of rhizoma polygonati and 2-5 parts of longan pulp.
4. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises:
15 parts of poria cocos, 15 parts of Chinese yam, 10 parts of spina date seed, 10 parts of medlar, 10 parts of chrysanthemum, 10 parts of rhizoma polygonati and 5 parts of longan pulp.
5. The traditional Chinese medicine composition according to claims 1-4, further comprising 0.01-0.1 part of walnut peptide, 0.01-1 part of phosphatidylserine, 0.01-1 part of N-acetylneuraminic acid and 0.1-5 parts of vitamin C.
6. A pharmaceutical, food or health product comprising the Chinese medicinal composition of any one of claims 1 to 5.
7. The medicine, food or health care product according to claim 6, wherein the auxiliary material is selected from one or more of maltodextrin, corn starch, microcrystalline cellulose, silicon dioxide, magnesium stearate, white granulated sugar, sorbitol, erythritol, maltitol, stevioside, sucralose, mogroside, gelatin, xanthan gum, seaweed gum, carrageenan, fruit powder and fruit juice.
8. The pharmaceutical, food or health product of claim 6, wherein the pharmaceutical, food or health product is selected from the group consisting of hard capsules, tablets, granules, soft capsules, oral liquids, tabletted candies, gel candies, vegetable drinks, solid beverages.
9. The use of the Chinese medicinal composition according to any one of claims 1 to 5 for preparing medicines, foods or health products for tranquillizing and nourishing brain, improving memory or improving insomnia.
10. A method of preparing the pharmaceutical, food or nutraceutical product of claim 6, comprising: weighing 15 parts of poria cocos, 15 parts of Chinese yam, 10 parts of spina date seed, 10 parts of medlar, 10 parts of chrysanthemum, 10 parts of rhizoma polygonati and 5 parts of longan pulp, cleaning, adding 5-15 times of water, decocting and extracting for 1-3 times and 0.5-3.0 h/time to obtain an extracting solution, mixing the extracting solutions, filtering, and concentrating into an extract with the relative density of 1.10-1.15 (55+/-5 ℃); drying the extract, pulverizing, sieving to obtain dry extract powder, adding vitamin C, phosphatidylserine, N-acetylneuraminic acid and walnut peptide, mixing, and adding pharmaceutically, health product or food acceptable adjuvants.
CN202310776662.7A 2023-06-27 2023-06-27 Traditional Chinese medicine composition for soothing nerves and improving intelligence as well as preparation method and application thereof Pending CN116712506A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102687888A (en) * 2012-05-30 2012-09-26 康美药业股份有限公司 Spina date seed beverage, and preparation method and application thereof
CN110038085A (en) * 2019-05-16 2019-07-23 徐州绿之野生物食品有限公司 A kind of preparation method and purposes of compound Semen Ziziphi Spinosae combined extracts
CN112843174A (en) * 2021-03-31 2021-05-28 建昌帮药业有限公司 Traditional Chinese medicine composition with functions of tonifying spleen, nourishing heart and soothing nerves, preparation method and application

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102687888A (en) * 2012-05-30 2012-09-26 康美药业股份有限公司 Spina date seed beverage, and preparation method and application thereof
CN110038085A (en) * 2019-05-16 2019-07-23 徐州绿之野生物食品有限公司 A kind of preparation method and purposes of compound Semen Ziziphi Spinosae combined extracts
CN112843174A (en) * 2021-03-31 2021-05-28 建昌帮药业有限公司 Traditional Chinese medicine composition with functions of tonifying spleen, nourishing heart and soothing nerves, preparation method and application

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