CN109045098A - A kind of lower hyperlipidemia, hypertension, hyperglycemia lozenge and preparation method thereof - Google Patents
A kind of lower hyperlipidemia, hypertension, hyperglycemia lozenge and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of lower hyperlipidemia, hypertension, hyperglycemia lozenges and preparation method thereof, the lower hyperlipidemia, hypertension, hyperglycemia lozenge is made of Ilex Latifolia Thunb, folium cortex eucommiae of raw material, and replace white granulated sugar, honey etc. to be not suitable for the sweetener that three high crowds eat Fructus Monordicae extract and arhat shell powder, so that lozenge is suitble to old man, pregnant woman, is eaten with three high crowds etc..Folium cortex eucommiae, the Ilex Latifolia Thunb mixing effective component extracting being added simultaneously make lozenge tool alleviate hypertension, hyperlipidemia, artery sclerosis, diabetes, obesity and other effects.
Description
Technical field
The present invention relates to a kind of lozenges and preparation method thereof, more particularly to a kind of lower hyperlipidemia, hypertension, hyperglycemia lozenge and preparation method thereof.
Background technique
Contain bitter leaves saponin, amino acid, vitamin C, Polyphenols, flavonoids, caffeine, protein etc. 200 in Ilex Latifolia Thunb
Multiple components.Energy bidirectional modulation organism metabolism, enhances immune function of human body, hence it is evident that the total gallbladder of serum for reducing hyperlipidemia patient is solid
Alcohol, triglycerides and low-density lipoprotein, it is convenient and other effects with pharynx-clearing throat-benefiting, clearing heat and detoxicating, liver-protecting and alcoholism-relieving, anti-inflammatory；It is also right
Hypertension, hyperlipidemia, artery sclerosis, diabetes, obesity, colitis, constipation, hemorrhoid and all kinds of oral inflammations etc. have significantly
Preventive and therapeutic effect.
Folium cortex eucommiae is micro- acrid in flavour and warm in nature, mainly contains Cortex Eucommiae chlorogenic acid, gutta-percha etc..With nourishing liver and kidney, strengthening the bones and muscles, blood pressure lowering, tune
Blood lipid is saved, prevention and treatment osteoporosis, hypoglycemic, tranquilizing and allaying excitement, antifatigue, analgesia, immunity, anti-inflammatory is improved, promotes glycometabolism, is anti-
Aging, inhibition uteri excitation and other effects.Wherein Cortex Eucommiae chlorogenic acid has antibacterial, anti-inflammatory, removing toxic substances, cholagogue, decompression and increases white thin
It born of the same parents and dramatically increases gastrointestinal peristalsis and promotes the pharmacological actions such as gastric secretion, to Escherichia coli, gold-coloured staphylococci, pneumococcus
There is stronger inhibiting effect with virus.
I is made company's double down bagged instant preparation of existing product Cortex Eucommiae of folium cortex eucommiae and Ilex Latifolia Thunb, records in the Sanitation Ministry medicine standard
The 12nd page 61 of Traditional Chinese medicine historical preparation, there is the effect of decompression, lipid-loweringing, be mainly used for blood pressure lowering and reducing blood lipid, but existing production
Product are taken after being infused in hot water or decoction by boiled water, are only that water decocts, wherein Ilex Latifolia Thunb part crushes and is directly used as medicine in preparation process, such simply to add
Work, the bitterness of folium cortex eucommiae, the sticky sense of gutta-percha are not easy to be covered by Ilex Latifolia Thunb, be easy to cause the sense of discomfort of millet paste entrance；Simply
Water boiling and extraction, part coarse granule directly brew and will also result in effective component and dissolve out incomplete defect.Therefore, to existing production
Product carry out the expansion in technologic optimization and dosage form, are the mains direction of studying of our company researcher.
In the research process to product, inventor discovery is arranged in pairs or groups using Siraitia grosvenorii and Ilex Latifolia Thunb, folium cortex eucommiae,
Reasonable auxiliary material is filtered out, buccal tablet is made, not only increases the dissolution of crude drug active constituent, and buccal tablet sugar content is low,
It is very suitable to take with three high crowds, also solves existing bagged instant preparation and brew the problems such as mouthfeel is not ideal enough, inconvenient to carry.Mesh
It is preceding to be directed in product made of folium cortex eucommiae and Ilex Latifolia Thunb, not yet there are the report of buccal tablet, a kind of hardship of CN201410047527.X
Fourth tea sugar-free buccal tablet and preparation method thereof discloses Ilex Latifolia Thunb, folium cortex eucommiae and pueraria lobata, castor leaf, gynostemma pentaphylla, Radix Salviae Miltiorrhizae, the dried immature fruit of citron orange
Deng lozenge made of nine kinds of medicinal materials, the preparation process of the product is only with simple water extract-alcohol precipitation, although in addition in the patent
It describes product to lay particular emphasis on clearing away heat and removing summer, promote the production of body fluid to quench thirst, anti-aging and other effects, but its practical function and effect is unknown.
Siraitia grosvenorii contains the medicinal ingredients such as mogroside, a variety of amino acid and vitamin, cures mainly lung heat phlegm-fire cough, pharynx
Laryngitis, tonsillitis, acute gastritis, constipation etc..Momordica-Glycosides is also known as sweetener than 300 times of sucrose sweet tea, because its sugariness is high,
Heat is low and is widely used as sweetener, is the best substitute of sucrose.Frequently as the alternative of overweight people and diabetic
Sugar has significant curative effect to diseases such as bronchitis, hypertension, still plays the work of prevention and treatment of coronary heart disease, vascular sclerosis, obesity
With.Therefore, it uses Siraitia grosvenorii as the sweetener and sugar in oral preparation, is the substitute products of the auxiliary materials such as ideal mannitol,
Three high crowds are not only advantageous for, and the function and effect of itself are also played.
Summary of the invention
The present invention for overcome the deficiencies in the prior art, by a large amount of recipe determination and verifying, provides a kind of drop three
High lozenge and preparation method thereof, be suitable for hypertension, hyperlipidemia, hyperglycemia edible for patients and meanwhile alleviation can also be played
The effect of illness.
Specifically, the present invention provides the following technical solutions:
A kind of lower hyperlipidemia, hypertension, hyperglycemia lozenge, it is characterised in that: calculate by weight, by 400-600 parts of folium cortex eucommiae, Ilex Latifolia Thunb 150-
250 parts, 5-15 parts of Fructus Monordicae extract, 2.5-7.5 parts of arhat shell powder, 10-20 parts of dextrin, 3-7 parts of hydroxyl isomaltulose, CMS-
2-6 parts of Na, 1-4 parts of magnesium stearate be made.
Preferably, it calculates by weight, by 450 parts of folium cortex eucommiae, 200 parts of Ilex Latifolia Thunb, 10 parts of Fructus Monordicae extract, Siraitia grosvenorii
5 parts of shell powder, 15 parts of dextrin, 5 parts of hydroxyl isomaltulose, 5 parts of CMS-Na, 2 parts of magnesium stearate be made.
Preparation method is the following steps are included: Siraitia grosvenorii, Ilex Latifolia Thunb, folium cortex eucommiae pretreatment, lozenge preparation step.
Siraitia grosvenorii pretreatment the following steps are included:
(1) Siraitia grosvenorii cleaned, dry rear shell and fruit stone separation；
(2) it is spare that Siraitia grosvenorii shell powder is obtained after being sieved after being crushed shell with 60-80 mesh screen；
(3) 10-20 times of water of mass fraction is added in fruit stone, boils rear small fire tanning 2-3h, is filtered using double gauze big
Type filter residue, filtrate are centrifugated 10-20min in 4500-5000r/min, take supernatant, filter residue is obtained by filtration using double gauze
Extraction, filtering 2 times is repeated with same steps, merges supernatant, combined supernatant is concentrated into former mixed extract volume
After it is spare.
The Ilex Latifolia Thunb, folium cortex eucommiae pretreatment remix to clean, drying respectively by Ilex Latifolia Thunb, folium cortex eucommiae, mix former material
10-15 times of water is added after feed powder is broken, in 90-100 DEG C of extraction 3-4h after boiling, after in 4500-5000r/min centrifuge separation 10-
20min takes supernatant, obtains filter residue with same steps and repeats extraction, filtering 2 times, merges supernatant, and combined supernatant is dense
It is reduced to the 1/10-1/20 of former mixed extract volume, concentrate is subjected to spray drying and obtains mixed extract powder.
Lozenge preparation the following steps are included:
(1) take recipe quantity Fructus Monordicae extract, arhat shell powder spare；
(2) Ilex Latifolia Thunb, the Cortex Eucommiae hinge extract powder for taking pretreatment to obtain, recipe quantity dextrin, hydroxyl isomaltulose, tristearin
Sour magnesium is spare；
(3) marumerization is used, by all components of aforementioned preparation merging spray-drying pelleting machine added together, is sprayed
Mist drying-granulating is made the granular powder that partial size is 40 mesh, is then formed using tabletting machine, obtain weight 0.4~
The lower hyperlipidemia, hypertension, hyperglycemia buccal tablet of 1.0g/ piece.
Wherein, spray drying granulation be using the aqueous solution of sodium carboxymethylcellulose as adhesive, solution concentration be 2%~
6%, liquid supply speed is 10~30ml/min, 40~70 DEG C of bed temperature, 0.15~0.25MPa of compression gas-pressure, when spraying granulation
Between be 40-80min.
The granulation process are as follows: by all components merging spray-drying pelleting machine added together, fluidized and realized
Powder mixing, spraying device starts, and in the continuous spray process of 40-80min, cohesion and long serious offense occur on powder for droplet
Journey, until required particle size stops by spraying.Finally, all granular products continue fluidized drying in same container, from
And the final product pelletized.
The invention has the benefit that Fructus Monordicae extract and arhat shell powder are replaced sucrose, honey, sweet by the 1, present invention
Dew alcohol etc. is not suitable for the sweetener that three high crowds eat, and reduces the usage amount of dextrin, and product is made to be suitble to old man, pregnant woman, trouble
There are three high crowds etc. edible.2, the mode for extracting, being centrifuged repeatedly is taken folium cortex eucommiae, Ilex Latifolia Thunb, obtains effective component sufficiently
It extracts, improves active constituent content in lozenge, strengthen lozenge and alleviate hypertension, hyperlipidemia, artery sclerosis, diabetes, fertilizer
The effect of fat disease, and the preparation method also effectively prevents bitter, the sticky problem of Cortex Eucommiae.3, mouth containing provided by the present invention
Piece, in good taste, good patient compliance also have both the function of hypoglycemic on the basis of original dosage form blood fat-reducing blood pressure-decreasing, extend product
Indication；The Fructus Monordicae extract and shell powder of addition have both the double action of auxiliary material and main ingredient, can improve the same of mouthfeel
When take into account curative effect, reach dual purpose.
Specific embodiment:
A specific embodiment of the invention is described in further detail below with reference to embodiment.
Embodiment 1: the pretreatment of raw material
Siraitia grosvenorii pretreatment: Siraitia grosvenorii is cleaned, dries rear shell and fruit stone separation；With 60 mesh after shell is crushed
It is spare that sieve obtains Siraitia grosvenorii shell powder after being sieved；10 times of water of mass fraction are added in fruit stone, rear small fire tanning 2h is boiled, adopts
Large-scale filter residue is filtered with double gauze, filtrate is centrifugated 10min in 4500r/min, takes supernatant, filtered using double gauze
It obtains filter residue and repeats extraction, filtering 2 times with same steps, merge supernatant, combined supernatant is concentrated into former mixing and is extracted
It is spare behind the 1/10 of liquid product.
Folium cortex eucommiae, Ilex Latifolia Thunb pretreatment: Ilex Latifolia Thunb 150g, folium cortex eucommiae 600g are cleaned respectively, dries and remixes, mixing is former
10 times of water are added after material disintegrating, in 90 DEG C of extraction 4h after boiling, after in 5000r/min centrifuge separation 10min, take supernatant,
It uses double gauze that filter residue is obtained by filtration and repeats extraction, filtering 2 times with same steps, merge supernatant, by combined supernatant
It is concentrated into the 1/10 of former mixed extract volume, it is spare that concentrate is carried out spray drying acquisition mixed extract powder.
Embodiment 2: the pretreatment of raw material
Siraitia grosvenorii pretreatment: Siraitia grosvenorii is cleaned, dries rear shell and fruit stone separation；With 70 mesh after shell is crushed
It is spare that sieve obtains Siraitia grosvenorii shell powder after being sieved；15 times of water of mass fraction are added in fruit stone, rear small fire tanning 3h is boiled, adopts
Large-scale filter residue is filtered with double gauze, filtrate is centrifugated 15min in 5000r/min, takes supernatant, filtered using double gauze
It obtains filter residue and repeats extraction, filtering 2 times with same steps, merge supernatant, combined supernatant is concentrated into former mixing and is extracted
It is spare behind the 1/15 of liquid product.
Folium cortex eucommiae, Ilex Latifolia Thunb pretreatment: Ilex Latifolia Thunb 250g, folium cortex eucommiae 400g are cleaned respectively, dries and remixes, mixing is former
15 times of water are added after material disintegrating, in 100 DEG C of extraction 3h after boiling, after in 4500r/min centrifuge separation 20min, take supernatant,
It uses double gauze that filter residue is obtained by filtration and repeats extraction, filtering 2 times with same steps, merge supernatant, by combined supernatant
It is concentrated into the 1/20 of former mixed extract volume, it is spare that concentrate is carried out spray drying acquisition mixed extract powder.
Embodiment 3: the pretreatment of raw material
Siraitia grosvenorii pretreatment: Siraitia grosvenorii is cleaned, dries rear shell and fruit stone separation；With 80 mesh after shell is crushed
It is spare that sieve obtains Siraitia grosvenorii shell powder after being sieved；20 times of water of mass fraction are added in fruit stone, boil rear small fire tanning 2.5h,
Large-scale filter residue is filtered using double gauze, filtrate is centrifugated 20min in 4500r/min, supernatant is taken, using double gauze mistake
Filter obtains filter residue and repeats extraction, filtering 2 times with same steps, merges supernatant, and combined supernatant is concentrated into former mixing and is mentioned
Take liquid product 1/20 after it is spare.
Folium cortex eucommiae, Ilex Latifolia Thunb pretreatment: Ilex Latifolia Thunb 200g, folium cortex eucommiae 450g are cleaned respectively, dries and remixes, mixing is former
13 times of water are added after material disintegrating, in 95 DEG C of extraction 3.5h after boiling, after in 4500r/min centrifuge separation 15min, take supernatant
Liquid uses double gauze that filter residue is obtained by filtration and repeats extraction, filtering 2 times with same steps, merges supernatant, by combined supernatant
Liquid is concentrated into the 1/15 of former mixed extract volume, and it is spare that concentrate is carried out spray drying acquisition mixed extract powder.
Embodiment 4: the pretreatment of raw material
Siraitia grosvenorii pretreatment: Siraitia grosvenorii is cleaned, dries rear shell and fruit stone separation；With 80 mesh after shell is crushed
It is spare that sieve obtains Siraitia grosvenorii shell powder after being sieved；20 times of water of mass fraction are added in fruit stone, rear small fire tanning 2h is boiled, adopts
Large-scale filter residue is filtered with double gauze, filtrate is centrifugated 15min in 5000r/min, takes supernatant, filtered using double gauze
It obtains filter residue and repeats extraction, filtering 2 times with same steps, merge supernatant, combined supernatant is concentrated into former mixing and is extracted
It is spare behind the 1/20 of liquid product.
Folium cortex eucommiae, Ilex Latifolia Thunb pretreatment: Ilex Latifolia Thunb 220g, folium cortex eucommiae 550g are cleaned respectively, dries and remixes, mixing is former
12 times of water are added after material disintegrating, in 95 DEG C of extraction 4h after boiling, after in 5000r/min centrifuge separation 18min, take supernatant,
It uses double gauze that filter residue is obtained by filtration and repeats extraction, filtering 2 times with same steps, merge supernatant, by combined supernatant
It is concentrated into the 1/15 of former mixed extract volume, it is spare that concentrate is carried out spray drying acquisition mixed extract powder.
Embodiment 5: the preparation of lozenge
Formula: folium cortex eucommiae, Ilex Latifolia Thunb mixed extract powder are embodiment 1-4 acquisition amount, Fructus Monordicae extract 5g, arhat
Shell powder 7.5g, dextrin 20g, hydroxyl isomaltulose 3g, CMS-Na 2g, magnesium stearate 1g.
Technique: (1) take recipe quantity Fructus Monordicae extract, arhat shell powder spare；
(2) Example 1-4 either method pre-processes Ilex Latifolia Thunb, Cortex Eucommiae hinge extract powder, recipe quantity paste
Essence, hydroxyl isomaltulose, magnesium stearate are spare；
(3) marumerization is used, by all components of aforementioned preparation merging spray-drying pelleting machine added together, is sprayed
Mist drying-granulating is made the granular powder that partial size is 40 mesh, is then formed using tabletting machine, obtain weight in 1.0g/ piece
Lower hyperlipidemia, hypertension, hyperglycemia buccal tablet 100.
Wherein, spray drying granulation is the solution concentration 2% using the aqueous solution of sodium carboxymethylcellulose as adhesive, is supplied
Liquid speed degree is 10ml/min, and 40 DEG C of bed temperature, 0.15~0.25MPa of compression gas-pressure, the spraying granulation time is 40min.
Embodiment 6: the preparation of lozenge
Formula: folium cortex eucommiae, Ilex Latifolia Thunb mixed extract powder are embodiment 1-4 acquisition amount, Fructus Monordicae extract 15g, sieve
Chinese shell powder 2.5g, dextrin 10g, hydroxyl isomaltulose 7g, CMS-Na 6g, magnesium stearate 4g.
Technique: (1) take recipe quantity Fructus Monordicae extract, arhat shell powder spare；
(2) Ilex Latifolia Thunb, the Cortex Eucommiae hinge extract powder for taking pretreatment to obtain, recipe quantity dextrin, hydroxyl isomaltulose, tristearin
Sour magnesium is spare；
(3) marumerization is used, by all components of aforementioned preparation merging spray-drying pelleting machine added together, is sprayed
Mist drying-granulating is made the granular powder that partial size is 40 mesh, is then formed using tabletting machine, obtain weight in 0.4g/ piece
Lower hyperlipidemia, hypertension, hyperglycemia buccal tablet 250.
Wherein, spray drying granulation is the solution concentration 6% using the aqueous solution of sodium carboxymethylcellulose as adhesive, is supplied
Liquid speed degree is 30ml/min, and 70 DEG C of bed temperature, 0.15~0.25MPa of compression gas-pressure, the spraying granulation time is 80min.
Embodiment 7: the preparation of lozenge
Formula: folium cortex eucommiae, Ilex Latifolia Thunb mixed extract powder are embodiment 1-4 acquisition amount, Fructus Monordicae extract 10g, sieve
Chinese shell powder 5g, dextrin 15g, hydroxyl isomaltulose 5g, CMS-Na 5g, magnesium stearate 2g.
Technique: (1) take recipe quantity Fructus Monordicae extract, arhat shell powder spare；
(2) Ilex Latifolia Thunb, the Cortex Eucommiae hinge extract powder for taking pretreatment to obtain, recipe quantity dextrin, hydroxyl isomaltulose, tristearin
Sour magnesium is spare；
(3) marumerization is used, by all components of aforementioned preparation merging spray-drying pelleting machine added together, is sprayed
Mist drying-granulating is made the granular powder that partial size is 40 mesh, is then formed using tabletting machine, obtain weight in 0.5g/ piece
Lower hyperlipidemia, hypertension, hyperglycemia buccal tablet 200.
Wherein, spray drying granulation is the solution concentration 5% using the aqueous solution of sodium carboxymethylcellulose as adhesive, is supplied
Liquid speed degree is 20ml/min, and 60 DEG C of bed temperature, 0.15~0.25MPa of compression gas-pressure, the spraying granulation time is 60min.
Test example 1:
Formula of the invention is summarized as follows by screening:
Prepare the raw material of buccal tablet according to the formula in table 1, formula is matched according to mass fraction:
100 are made above, every weighs about 1.0-1.5g.Specific preparation method are as follows:
Folium cortex eucommiae and Ilex Latifolia Thunb are extracted using primary standard in method 1,2, remaining method 3-7 is extracted using the method for the present invention,
Then with other auxiliary material spray-drying processes, tabletting.
Buccal tablet will be made in above-mentioned seven screening techniques and carry out sensory evaluation, determination of chlorogenic acid, friability, disintegration
The inspection in time limit, as a result such as table 2:
2 lower hyperlipidemia, hypertension, hyperglycemia lozenge index checking result of table
The result shows that forming and matching using the supplementary material of method 3, work well.
Test example 2:
For the curative effect that can further verify the invention, this researcher is tested as follows in the invention
Verifying:
1, experimental group designs
Contrast groups 1: the double down bagged instant preparation of Cortex Eucommiae, original standard are prepared into bagged instant preparation, and every consumption per day is 3 bags.
Contrast groups 2: the prescription of method 2 in Selection experiment example 1 is prepared by 7 manufacture craft of the embodiment of the present invention.
2, Testing index
Mouse lowering blood pressure and blood fat, function of blood sugar reduction experiment are carried out to the product of embodiment 5-7 and contrast groups 1-2.
1) rat antihypertensive function is tested
70 age 5 months original hypertensive rats (SHR) are selected in experiment, are randomly divided into 1 group of blank negative control
Group, 1 group of positive controls, 6 groups tested group.
Blank negative control group: basic feed, free water are fed；
Positive controls: daily according to 25mg/kg feeding captopril (captopril), basic feed is fed, is freely drunk
Water；
Tested group: tested group 1-3 uses the product of embodiment 5-7；Tested group of 4-5 uses the product of contrast groups 1-2, freely
Drinking-water, dosage is 5 times of the daily usage amount of people.
Continuous use 4 weeks measures weekly a blood pressure.
2) rat hypolipemic function is tested
70 SD male rats (180-220g) are selected in experiment, are randomly divided into 1 group of Normal group, 1 group model control group,
5 groups tested group.Model control group and tested group are fed daily with high lipid food, free water for modeling one month.After the completion of modeling:
Normal group: basic feed, free water are fed；
Model control group: feed high lipid food, free water；
Tested group: tested group 1-3 uses the product of embodiment 5-7；Tested group of 4-5 uses the product of contrast groups 1-2, freely
Drinking-water, dosage is 5 times of the daily usage amount of people.
The formula of high lipid food are as follows: based on basal feed, add the cholesterol of 1.5g/100g, the egg of 1.5g/100g
Bloom, the lard of 1.5g/100g, the cholate of 0.25g/100g.
Fasting 16h after nursing 45d, eyeball takes blood, using corresponding reagent box cholesterol detection (TC), low-density lipoprotein gallbladder
Sterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) are horizontal.
3) mouse function of blood sugar reduction is tested
70 mouse (25-30g) are selected in experiment, are randomly divided into 1 group of Normal group, 1 group model control group, 5 groups tested
Group.Model control group and tested group are continuously modeled 15 days with alloxan, 45mg/kg is fresh matches to mouse peritoneal injection daily
The alloxan of system.After the completion of modeling:
Normal group: basic feed, free water are fed；
Model control group: basic feed, free water are fed；
Tested group: tested group 1-3 uses the product of embodiment 5-7；Tested group of 4-5 uses the product of contrast groups 1-2, freely
Drinking-water, dosage is 5 times of the daily usage amount of people.
After feeding 45d, fasting 3h, eye socket takes blood, and isolated serum detects fasting blood sugar with blood sugar kit.
3, testing result
1) rat antihypertensive function is tested
Table 1SHR pressure value (mmHg) result of variations
| Experimental group | Before administration | 1 week | 2 weeks | 3 weeks | 4 weeks |
| Blank negative control group | 125.1±2.0a | 124.3±4.2a | 121.5±2.3a | 125.6±3.2a | 126.1±2.7a |
| Positive controls | 122.9±2.5a | 91.8±4.1bc | 89.4±3.8c | 88.6±2.9c | 85.7±3.6c |
| Tested group 1 | 123.1±3.4a | 103.2±3.9b | 99.8±3.1b | 97.2±2.8bc | 92.7±1.9bc |
| Tested group 2 | 127.3±1.8a | 105.3±1.3b | 102.8±3.2b | 98.6±2.8b | 93.5±3.1b |
| Tested group 3 | 124.5±2.3a | 101.2±1.5b | 98.1±3.9bc | 96.8±3.2bc | 91.8±1.4bc |
| Tested group 4 | 121.2±3.9a | 115.4±4.0a | 110.2±5.1a | 108.5±4.2a | 106.2±5.3a |
| Tested group 5 | 124.2±4.1a | 108.5±3.2a | 105.0±4.5a | 101.9±3.9a | 95.1±5.1a |
Table 1 is as the result is shown: blank negative control group pressure value, which is always maintained at not having steadily, obviously rises or falls trend；Sun
Property control group pressure value (mmHg) is decreased obviously for first week, subsequent continuation position pressure value held stationary.Tested group of 1-3,5SHR
Pressure value (mmHg) is also decreased obviously for first week, subsequent continuation position pressure value held stationary, though and positive controls there is also
It some difference but is decreased obviously compared with blank negative control group pressure value, and tested group of 5 effects are slightly lower.After tested group 4 is declined slightly
It tends to be steady, but the difference compared with blank negative control group does not have tested group of 1-3 obvious.Illustrate formula and technique of the invention
Step is reasonable, achievees the effect that reduction, stabilizing blood pressure and crude drug dosage reduce.
2) mouse hypolipemic function is tested
2 Rat Cholesterol value result of variations of table
Table 2 is as the result is shown: tested group of 1-3,5 cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density
Lipoprotein cholesterol (HDL-C) though value is more slightly higher than normally organizing, substantially less than model control group, but tested group of 5 effects are slightly lower.By
The indices numeric ratio model control group of examination group 4 is low, but the difference compared with model group does not have tested group of 1-3 obvious.Explanation
Formula and processing step of the invention is reasonable, achievees the effect that reduce blood lipid and raw material usage amount reduces.
3) mouse function of blood sugar reduction is tested
3 mouse fasting blood sugar result of variations of table
| Experimental group | Fasting blood sugar (mmol/L) |
| Normal group | 8.56±2.31a |
| Model control group | 20.56±3.30c |
| Tested group 1 | 13.22±2.51ab |
| Tested group 2 | 12.43±2.31ab |
| Tested group 3 | 13.51±3.01ab |
| Tested group 5 | 25.42±2.18cd |
| Tested group 6 | 21.55±3.33c |
| Tested group 7 | 18.05±2.30c |
Though table 3 the results show that tested group of 1-3,5 fasting blood sugar it is more slightly higher than normally organizing, substantially less than model comparison
Group, but tested group of 5 effects are slightly lower.Difference of tested group 4 of the indices numerical value compared with model group does not have tested group of 1-3 bright
It is aobvious.Illustrate that formula and processing step of the invention are reasonable, achievees the effect that reduce blood glucose and raw material usage amount reduces.
Claims (7)
1. a kind of lower hyperlipidemia, hypertension, hyperglycemia lozenge, it is characterised in that: calculate by weight, by 400-600 parts of folium cortex eucommiae, Ilex Latifolia Thunb 150-250
Part, 5-15 parts of Fructus Monordicae extract, 2.5-7.5 parts of arhat shell powder, 10-20 parts of dextrin, 3-7 parts of hydroxyl isomaltulose, CMS-Na
2-6 parts, 1-4 parts of magnesium stearate are made.
2. lower hyperlipidemia, hypertension, hyperglycemia lozenge as described in claim 1, it is characterised in that: calculate by weight, by 450 parts of folium cortex eucommiae, bitter leaves
200 parts of tea, 10 parts of Fructus Monordicae extract, 5 parts of arhat shell powder, 15 parts of dextrin, 5 parts of hydroxyl isomaltulose, 5 parts of CMS-Na, tristearin
2 parts of sour magnesium is made.
3. the method for preparing lower hyperlipidemia, hypertension, hyperglycemia lozenge as described in claim 1, which is characterized in that including Siraitia grosvenorii, Ilex Latifolia Thunb, Cortex Eucommiae
Leaf pretreatment, lozenge preparation step.
4. the preparation method of lower hyperlipidemia, hypertension, hyperglycemia lozenge as claimed in claim 3, which is characterized in that Siraitia grosvenorii pretreatment include with
Lower step:
(1) Siraitia grosvenorii cleaned, dry rear shell and fruit stone separation；
(2) it is spare that Siraitia grosvenorii shell powder is obtained after being crushed step (1) shell, after being sieved with 60-80 mesh screen；
(3) 10-20 times of water of mass fraction is added in step (1) fruit stone, boils rear small fire tanning 2-3h, is filtered using double gauze
Large-scale filter residue, filtrate are centrifugated 10-20min in 4500-5000r/min, take supernatant, filter is obtained by filtration using double gauze
Slag repeats extraction, filtering 2 times with same steps, merges supernatant, combined supernatant is concentrated into former mixed extract volume
1/10-1/20 after it is spare.
5. the preparation method of lower hyperlipidemia, hypertension, hyperglycemia lozenge as claimed in claim 3, which is characterized in that the Ilex Latifolia Thunb, folium cortex eucommiae are located in advance
Reason are as follows: recipe quantity Ilex Latifolia Thunb, folium cortex eucommiae to be cleaned respectively, dries and remixes, 10-15 times of water is added after crushing in mixed raw material,
In 90-100 DEG C of extraction 3-4h after boiling, after in 4500-5000r/min be centrifugated 10-20min, take supernatant, obtain filter residue
Extraction, filtering 2 times is repeated with same steps, merges supernatant, combined supernatant is concentrated into former mixed extract volume
, concentrate is subjected to spray drying and obtains mixed extract powder.
6. the preparation method of lower hyperlipidemia, hypertension, hyperglycemia lozenge as claimed in claim 3, which is characterized in that the lozenge preparation includes following step
It is rapid:
(1) take recipe quantity Fructus Monordicae extract, arhat shell powder spare；
(2) Ilex Latifolia Thunb, the Cortex Eucommiae hinge extract powder for taking pretreatment to obtain, recipe quantity dextrin, hydroxyl isomaltulose, magnesium stearate
It is spare；
(3) marumerization is used, by all components of aforementioned preparation merging spray-drying pelleting machine added together, is done by spraying
Dry granulation is made the granular powder that partial size is 40 mesh, is then formed using tabletting machine, obtain weight in 0.4~1.0g/ piece
Lower hyperlipidemia, hypertension, hyperglycemia buccal tablet.
7. the preparation method of lower hyperlipidemia, hypertension, hyperglycemia lozenge as claimed in claim 6, it is characterised in that: spray drying in the step (3)
Granulation is using the aqueous solution of sodium carboxymethylcellulose as adhesive, and solution concentration is 2%~6%, and liquid supply speed is 10~30ml/
Min, 40~70 DEG C of bed temperature, 0.15~0.25MPa of compression gas-pressure, the spraying granulation time is 40-80min.
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| CN201810759359.5A CN109045098A (en) | 2018-07-11 | 2018-07-11 | A kind of lower hyperlipidemia, hypertension, hyperglycemia lozenge and preparation method thereof |
| PCT/CN2019/085147 WO2020010904A1 (en) | 2018-07-11 | 2019-04-30 | Lozenge for lowering blood fat, blood pressure and blood glucose and preparation method therefor |
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| CN109349642A (en) * | 2018-12-26 | 2019-02-19 | 陕西天承生物科技股份有限公司 | A kind of folium cortex eucommiae compound buccal lozenge and preparation method thereof improved the immunity of the human body |
| CN110237116A (en) * | 2019-07-11 | 2019-09-17 | 贵州神奇药业有限公司 | A kind of lower hyperlipidemia, hypertension, hyperglycemia composition and preparation method thereof |
| WO2020010904A1 (en) * | 2018-07-11 | 2020-01-16 | 贵州神奇药业有限公司 | Lozenge for lowering blood fat, blood pressure and blood glucose and preparation method therefor |
| CN112273292A (en) * | 2020-11-25 | 2021-01-29 | 中国海洋大学 | Culture method of juvenile turbot |
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| WO2020010904A1 (en) | 2020-01-16 |
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Application publication date: 20181221 |