CN1166383C - Medicine for treating tumor in digestive tract and its prepn - Google Patents
Medicine for treating tumor in digestive tract and its prepn Download PDFInfo
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- CN1166383C CN1166383C CNB011175214A CN01117521A CN1166383C CN 1166383 C CN1166383 C CN 1166383C CN B011175214 A CNB011175214 A CN B011175214A CN 01117521 A CN01117521 A CN 01117521A CN 1166383 C CN1166383 C CN 1166383C
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Abstract
The present invention relates to a medicament for treating tumors in the digestive tract, more specifically a Chinese patent medicine prepared from Chinese herbal medicine as raw materials. The present invention also relates to a method for preparing the medicament. The medicine is prepared from lagerstroemia indica, mustard seed, ginseng, bletilla tuber, figwort root, forsythia fruit, trogopterus dung, scorpion, green tangerine peel, fresh oyster shell, calcined concha arcae and licorice root as raw materials. According to different characteristics of each kind of traditional Chinese medicine, the raw materials are respectively processed by freeze drying or air drying or solvent extraction and are prepared in a certain proportion, and then, the raw materials are aged, sterilized and prepared into powder or capsules and pills. The medicament has the functions for clearing heat and toxin, promoting blood circulation for removing obstruction in collaterals, softening and resolving hard mass, invigorating vital energy and promoting blood circulation, and has obvious curative effects for treating tumors in the digestive tract tumor, such as esophagus cancer, carcinoma of gastric cardia, gastric cancer and intestinal cancer.
Description
The present invention relates to a kind of medicine for the treatment of digestive tract tumor, specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.The invention still further relates to the preparation method of this medicine.
Digestive tract tumor is the common frdquently encountered disease of serious harm human health, and mortality rate is very high.Digestive tract tumor comprises the esophageal carcinoma, carcinoma of gastric cardia, gastric cancer, colorectal cancer, the medicine for the treatment of digestive tract tumor at present clinically has a lot, the Western medicine side effect of wherein treating digestive tract tumor is bigger, and the Chinese medicine effect that is used for the treatment of digestive tract tumor at present is undesirable, therefore at present clinically still the Chinese herbal medicine combination preparation of demand with definite curative effect be used for the treatment of digestive tract tumor.
Both at home and abroad to the primary disease Drug therapy, run into following thorny problem at present.
1, western medicine is long the course of treatment, and the price height easily causes the infringement to normal organ, the individual drug weak curative effect.
2, also there is the unfavorable problem of curative effect in other Chinese medicine compositions.
Order of the present invention is to provide that a kind of like this what digestive tract tumor was had definite curative effect is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.This medical instrument has heat-clearing and toxic substances removing, eliminating blood stasis and smoothing collaterals, softening the hard mass knot, inrigorating qi and promoting blood circulation effect.
Another object of the present invention provides the preparation method of this digestive tract tumor's therapeutic agent.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to digestive tract tumor invasion mechanism, newly achieve with reference to modern pharmacological research, in conjunction with clinical data for many years, from motherland's medicine treasure-house, filter out the pure natural plant medicine of heat-clearing and toxic substances removing, eliminating blood stasis and smoothing collaterals, softening the hard mass knot, inrigorating qi and promoting blood circulation, according to the theory of Chinese medical science prescription, extract the medicine elite by the modern science and technology means.Make its performance strengthen patient's immunocompetence, kill cancerous cell, tumor tissues is diminished or disappears, alleviate patient's pain simultaneously, prolong patient's life span, the effect of raising patient's life quality.
The present invention forms (consumption is a weight portion) Lagerstroemia indica L. 10-25 part by following component; Mustard seed 10-20 part; Radix Ginseng 5-15 part; Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part; Radix Scrophulariae 5-15 part; Fructus Forsythiae 10-25 part; Oletum Trogopterori 5-15 part; Scorpio 5-10 part; Pericarpium Citri Reticulatae Viride 10-15 part Concha Ostreae 5-25 part Concha Arcae (calcined) 5-25 part; Radix Glycyrrhizae 15-25 part;
The formula optimization weight proportion scope of preparation medicine of the present invention is: Lagerstroemia indica L. 8-15 part; Mustard seed 10-15 part; Radix Ginseng 6-10 part; Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part; Radix Scrophulariae 6-10 part; Fructus Forsythiae 10-15 part; Oletum Trogopterori 6-10 part; Scorpio 6-10 part; Pericarpium Citri Reticulatae Viride 10-12 part Concha Ostreae 5-15 part; Concha Arcae (calcined) 10-20 part; Radix Glycyrrhizae 15-20 part;
Optimum weight proportioning of the present invention is: 10 parts of Lagerstroemia indica L.s; 10 parts of mustard seed; 8 parts of Radix Ginsengs; 5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s; 6.5 parts of Radix Scrophulariaes; 10 parts of Fructus Forsythiaes; 6.5 parts of Oletum Trogopteroris; 8 parts of Scorpios; 10 parts on Pericarpium Citri Reticulatae Viride; 10 parts of Concha Ostreae; 10 parts of Concha Arcae (calcined); 16.5 parts in Radix Glycyrrhizae;
Active component in the pharmaceutical composition of the present invention can be the Chinese drugs powder or the extract of said ratio, and optional water of extract and alcohol are solvent, preferred alcohol, and concentration is 95%, extracting method is conventional decocting method.
Above-mentioned each component is made production method of the present invention:
1, gets the freezing back of Scorpio earlier and pulverize, dried 120 mesh sieves.
2, Lagerstroemia indica L., mustard seed, Radix Ginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Scrophulariae, Fructus Forsythiae, Oletum Trogopterori, Concha Ostreae, Pericarpium Citri Reticulatae Viride, Concha Arcae (calcined), Radix Glycyrrhizae are ground into 120 order fine powders after air-dry, also can extract with an alcoholic solution, discard residue, after extracting solution concentrates, the residue drying, with Scorpio powder mixing, make powder.
3, with above-mentioned whole powder components by after the described mixed, under 100-110 ℃, carry out ripening, sterilization treatment 10-30 minute, can obtain needed medicine.Medicine after the maturation process can encapsulatedly be made capsule, also can add processed with honey and become pill, also can directly make powder for clinical use.
An important feature of the present invention is that Lagerstroemia indica L. that will have promoting blood circulation and hemostasis, detoxifcation, a detumescence effect and the mustard seed with promoting the circulation of QI eliminating phlegm, cold expelling, reducing swelling and alleviating pain are as the principal agent in the treatment digestive tract tumor prescription.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the selected medicine of the present invention is the pure natural plant medicine, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment digestion tumor of the Chinese medicine of respectively distinguishing the flavor of nontoxic to human body.
2, taking convenience of the present invention meets the national health law regulation.
3, early stage patient uses the back therapeutic effect obviously to increase, and mid-term or patients with terminal should strengthen medication dose to guarantee curative effect.
4, can alleviate patient's pain significantly, reduce or eliminate cancerous protuberance, prolong patient's life span.
For showing medicine of the present invention to digestive tract tumor treatment effect, the present invention is through the clinical observation of 150 routine systems, and selects 50 examples to be matched group, and the observation situation is as follows:
1, clinical data:
This group data is taken from Siping City institute of traditional Chinese medicine oncology, totally 150 examples, and esophageal carcinoma 38 examples wherein, gastric cancer 65 examples, carcinoma of gastric cardia 30 examples, intestinal cancer 17 examples, male's 123 examples, women's 27 examples, in age 26-72 year, average 49 years old, the patient clarified a diagnosis by methods such as B ultrasonic CT, MRI
2, Therapeutic Method and observation index:
The all oral medicine of the present invention of this group patient, instructions of taking, one time 15, day clothes 3 times, warm water delivery service, three months is a course of treatment, matched group is established 50 examples, selects for use TIANXIAN WAN to take.
Observation index: observe and treat relaxing tumor pain in back three months, diet situation, the variation of the size of physical situation and tumor and life span.
3, efficacy analysis:
3.1, the feed; To the digestive tract person of blocking is arranged, dysphagia or drinking-water can not pass through the person, including of row oral cavity, swallow, and as vomitting, containing again after half an hour, morning person can be intake after 12 hours, can advance semi-fluid after 48 hours and eat, and ten days courses of treatment, the good person of effect can advance general food.
3.2, the pain relieving situation; Take this medicine to patient's chest pain, back pain, precordialgia, having a stomach-ache all has in various degree the effect that alleviates, and the part patient body weight increases.
3.3, effective percentage; Treatment group effective percentage is 66.6%, and matched group is 53.2%, two group and compares that difference has significance (P＜0.05).
3.4, prolong life span: make barium meal or CT examination after 3-4 the course of treatment of taking medicine, block above esophagectasia and alleviate, lump dwindles about about 0.2cm, and the barium agent is passed through more smooth, prolongation patient life span.
4, know from experience: treat digestive tract tumor at present and take herbal treatment more, have certain advantage, we think that this medicine is a kind of promising cancer therapy drug, and patient's late result and survival rate are expected to be improved.
Embodiment:
Take by weighing raw material by following proportioning; Lagerstroemia indica L. 10kg, mustard seed 10kg, Radix Ginseng 8kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 5kg, Radix Scrophulariae 6.5kg, Fructus Forsythiae 10kg, Oletum Trogopterori 6.5kg, Scorpio 8kg, Pericarpium Citri Reticulatae Viride 10kg, Concha Ostreae 10kg, Concha Arcae (calcined) 10kg, Radix Glycyrrhizae 16.5kg.Production method is as follows: earlier Scorpio is frozen into the ice shape, rubs with meat grinder, dried 120 mesh sieves.Again with Lagerstroemia indica L., mustard seed, Radix Ginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Scrophulariae, Fructus Forsythiae, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Concha Ostreae, Concha Arcae (calcined), be ground into 120 order fine powders after Radix Glycyrrhizae is air-dry or with the alcoholic solution extraction, discard residue, after extract concentrated, the dry and Scorpio powder mixing of residue was made powder and is crossed 120 mesh sieves; Above-mentioned fine powder component by after the described mixed, is incubated 10 minutes down at 110 ℃, and then cools to 105 ℃ of insulations 5 minutes, and then reduce to 100 ℃ of insulations 15 minutes, carry out the ripening sterilization, make powder or capsule.
Claims (5)
1, a kind of medicine for the treatment of digestive tract tumor is characterized in that: it is the medicament of being made by following proportion raw material:
Lagerstroemia indica L. 10-25 part; Mustard seed 10-20 part; Radix Ginseng 5-15 part; Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part;
Radix Scrophulariae 5-15 part; Fructus Forsythiae 10-25 part; Oletum Trogopterori 5-15 part; Scorpio 5-10 part;
Pericarpium Citri Reticulatae Viride 10-15 part; Concha Ostreae 5-25 part Concha Arcae (calcined) 5-25 part; Radix Glycyrrhizae 15-25 part.
2, medicine for the treatment of digestive tract tumor according to claim 1, wherein each proportion of raw materials is:
Lagerstroemia indica L. 8-15 part; Mustard seed 10-15 part; Radix Ginseng 6-10 part; Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part;
Radix Scrophulariae 6-10 part; Fructus Forsythiae 10-15 part; Oletum Trogopterori 6-10 part; Scorpio 6-10 part;
Pericarpium Citri Reticulatae Viride 10-12 part Concha Ostreae 5-15 part; Concha Arcae (calcined) 10-20 part; Radix Glycyrrhizae 15-20 part.
3, medicine for the treatment of digestive tract tumor according to claim 1, wherein each proportion of raw materials is:
10 parts of Lagerstroemia indica L.s; 10 parts of mustard seed; 8 parts of Radix Ginsengs; 5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s;
6.5 parts of Radix Scrophulariaes; 10 parts of Fructus Forsythiaes; 6.5 parts of Oletum Trogopteroris; 8 parts of Scorpios;
10 parts on Pericarpium Citri Reticulatae Viride; 10 parts of Concha Ostreae; 10 parts of Concha Arcae (calcined); 16.5 parts in Radix Glycyrrhizae;
4, according to claim 1,2 or 3 described medicines for the treatment of digestive tract tumor, it is characterized in that said medicament is capsule and pill.
5, preparation method for the treatment of the medicine of digestive tract tumor according to claim 4 is characterized in that the preparation method of described capsule and pill is as follows:
1) gets the freezing back of Scorpio, earlier and pulverize, dried 120 mesh sieves;
2), Lagerstroemia indica L., mustard seed, Radix Ginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Scrophulariae, Fructus Forsythiae, Oletum Trogopterori, Concha Ostreae, Pericarpium Citri Reticulatae Viride, Concha Arcae (calcined), Radix Glycyrrhizae are ground into 120 order fine powders after air-dry, also can extract with an alcoholic solution, discard residue, after extracting solution concentrates, the residue drying, with Scorpio powder mixing, make powder;
3), with above-mentioned whole powder components by after the described mixed, under 100-110 ℃, carry out ripening, sterilization treatment 10-30 minute, can obtain needed medicine.Medicine after the maturation process can encapsulatedly be made capsule, also can add processed with honey and become pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011175214A CN1166383C (en) | 2001-05-30 | 2001-05-30 | Medicine for treating tumor in digestive tract and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011175214A CN1166383C (en) | 2001-05-30 | 2001-05-30 | Medicine for treating tumor in digestive tract and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1387873A CN1387873A (en) | 2003-01-01 |
| CN1166383C true CN1166383C (en) | 2004-09-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB011175214A Expired - Fee Related CN1166383C (en) | 2001-05-30 | 2001-05-30 | Medicine for treating tumor in digestive tract and its prepn |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106421660A (en) * | 2016-11-17 | 2017-02-22 | 佛山科学技术学院 | Traditional Chinese medicine drug granule for complementing element and eliminating blockage |
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- 2001-05-30 CN CNB011175214A patent/CN1166383C/en not_active Expired - Fee Related
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