CN116509827A - Clean skin disinfectant and application thereof - Google Patents

Clean skin disinfectant and application thereof Download PDF

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Publication number
CN116509827A
CN116509827A CN202310480761.0A CN202310480761A CN116509827A CN 116509827 A CN116509827 A CN 116509827A CN 202310480761 A CN202310480761 A CN 202310480761A CN 116509827 A CN116509827 A CN 116509827A
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disinfectant
skin
lipids
skin disinfectant
nonionic
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白玉璞
成云凤
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Tianjin University
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Tianjin University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The application discloses a clean skin disinfectant and application thereof, wherein the clean skin disinfectant comprises the following components: a disinfectant; nonionic glycolipid compounds; an organic solvent. The nonionic glycolipid compound in the skin disinfectant can remarkably improve the cleaning performance of the skin disinfectant, can fully clean the skin, and avoids sweat residues from influencing blood detection; adopting a nonionic system, avoiding introducing new ions and interfering with the detection of blood samples; by compounding the disinfectant and the nonionic glycolipid compound, the content of non-volatile substances in the disinfectant formula combination can be greatly reduced, the skin disinfectant is ensured to have excellent microorganism killing performance and cleaning and decontaminating performance, the residue of the disinfectant on the skin after use is reduced to the greatest extent, and the risk that the non-volatile substances interfere with the subsequent blood sample detection process is reduced.

Description

Clean skin disinfectant and application thereof
Technical Field
The application belongs to the technical field of disinfectants, and in particular relates to a clean skin disinfectant and application thereof.
Background
In the application of skin disinfectants, there is a class of subdivision application scenarios, namely, people use disinfectants to disinfect the part to be sampled before taking peripheral blood samples for certain in vitro diagnostic items (such as blood sugar, blood fat, uric acid, etc.). At present, the disinfectant with the purposes is almost all disinfectant alcohol, and mainly has the advantages of wide sterilization range, easy volatilization, easy acquisition (low cost) and the like.
However, since the fingertip is one of the most concentrated sweat glands, when moisture in sweat evaporates, the non-volatile substances remain on the skin of the fingertip, and as the process of sweat discharge and moisture evaporation of the fingertip proceeds, the non-volatile substances accumulate and become very considerable in quantity, and mainly include inorganic salts (sodium ions, potassium ions, chloride ions, etc.), urea, lactic acid, uric acid, grease, etc.
Although it is often stated that both hands should be cleaned before blood collection in the related instructions for in vitro diagnostic reagents, in actual situations, most operators will not or cannot perform hand washing operation due to operation habits or due to condition limitations, but rather use alcohol cotton chips for very simple disinfection and wiping, which includes a large number of Point of care (POC) situations. While there is often a significant accumulation of dirt on the skin of the fingertips, which is a complex mixture of grease, inorganic salts and many other metabolic products, disinfecting alcohol (70% -80% v/v) is difficult to effectively remove due to its limited cleaning capacity, especially when many individuals have a deep fingerprint. Since blood has good solubility properties including dissolution of metabolic inorganic salts, uric acid, lactic acid, and fat-soluble fatty acids, etc., when finger-pricking with a lancet is performed for collection of fingertip blood, the blood sample flows out to form droplets and comes into contact with fingertip skin, and the above sweat residues rapidly spread in the blood sample and form interference with detection of analytes.
The current market is mature and has high popularity, and most of the slow disease daily monitoring indexes such as blood sugar, uric acid, blood fat and the like adopt an electrochemical platform; in such methodological platforms, hematocrit is a very important correction parameter, which is measured basically by means of an alternating current impedance method, i.e. by measuring the impedance signal of a blood sample between two specific electrodes, calculating the hematocrit by means of an algorithm. However, the dissolution of inorganic salts in sweat residues on the skin of the fingertip into the blood sample significantly alters the electrical conductivity properties of the blood sample, thereby affecting the hematocrit measurement and thus the results of the test index, which is particularly pronounced for low-pressure and high-pressure product samples.
In uric acid detection, the average content of uric acid in human sweat reaches 0.214 mu mol/mL, and the blood sample volume required by the electrochemical detection of related indexes is very small and only a few microliters, so that if uric acid in sweat residues is dissolved into fingertip blood samples, the blood uric acid indexes can be greatly interfered.
Therefore, the invention provides a disposable disinfectant which is easy to use and can effectively remove sweat residues of palm skin, and has a practical and necessary requirement in an application scene of taking fingertip blood for instant detection.
Disclosure of Invention
The utility model provides a clean skin disinfectant and application thereof to solve the technical problem that conventional medical disinfection alcohol that exists among the prior art has limited clean ability, can't effectively clear away sweat residue, and sweat residue is quick diffusion and formation wait analyte detection's interference in blood sample when collecting peripheral blood.
In order to solve the problems, one technical scheme adopted by the application is as follows:
provided is a cleansing type skin disinfectant comprising the following components:
a disinfectant;
nonionic glycolipid compounds;
an organic solvent.
In one or more embodiments, the disinfectant is at a concentration of 0.05 to 1.0% w/v and the nonionic glycolipid compound is at a concentration of 0.02 to 1.4% w/v.
In one or more embodiments, the volume fraction of the organic solvent is 40% to 65%.
In one or more embodiments, the nonionic glycolipid compounds include one or more combinations of trehalose lipids, sophorolipids, mannitol erythritol lipids, amber-trehalose lipids, cellobiose lipids.
In one or more embodiments, the nonionic glycolipid compounds include a combination of sophorolipids, mannohydroerythritol lipids, cellobiose lipids.
In one or more embodiments, the weight ratio of sophorolipids, mannosyl erythritol lipids, cellobiose lipids is 2:3:3.
in one or more embodiments, the disinfectant includes one or a combination of both parachlorometaxylenol and trichlorohydroxydiphenyl ether.
In one or more embodiments, the organic solvent includes one or more combinations of ethanol, isopropanol, and n-propanol.
In order to solve the above problems, another technical solution adopted in the present application is:
there is provided a use of the skin sanitizing agent according to any of the above embodiments for sanitizing skin prior to lancing the tip of a fingertip.
The beneficial effect of this application is, in contrast to prior art:
the nonionic glycolipid compound in the skin disinfectant can remarkably improve the cleaning performance of the skin disinfectant, can fully clean the skin, and avoids sweat residues from influencing blood detection;
the skin disinfectant adopts a nonionic system, so that new ions are prevented from being introduced and the interference of the new ions on the detection of blood samples is avoided; the nonionic glycolipid compound has extremely low CMC value, and can obviously reduce the addition amount of the surfactant in the formula while meeting the corresponding efficacy, thereby maximally reducing the residue of the disinfectant on the skin after use; the non-volatile matter content in the disinfectant formula combination can be greatly reduced by compounding the disinfectant and the nonionic glycolipid compound, so that the skin disinfectant is ensured to have excellent microorganism killing performance and cleaning and decontaminating performance, and the risk that the non-volatile matter interferes with the subsequent blood sample detection process is furthest reduced;
compared with other disinfectants, the skin disinfectant disclosed by the application is milder to the skin, has a certain protection and repair effect, and avoids the problems of skin dryness and skin irritation which are easily generated by other disinfectants;
the skin disinfectant disclosed by the application remarkably improves the killing effect of the skin disinfectant by compounding the nonionic glycolipid compound and the disinfectant, and endows the applied skin area with extremely wide antibacterial, antiviral and antifungal capabilities.
Detailed Description
The present application will be described in detail with reference to the embodiments. The embodiments are not intended to be limiting and structural, methodological, or functional changes made by those of ordinary skill in the art in light of the embodiments are intended to be included within the scope of the present application.
As described in the background art, when collecting tip blood of a fingertip, residual nonvolatile substances of sweat of the fingertip can influence the accuracy of detection of hematocrit, uric acid and the like. However, the prior sterilizing alcohol (70% -80% v/v) is difficult to effectively remove due to the limited cleaning capacity, especially when many individuals have deep fingerprints.
In order to solve the above problems, the applicant has developed a skin disinfectant capable of disinfecting and cleaning the skin, which has a strong cleaning ability and a good disinfecting performance, and which can sufficiently clean sweat non-volatile substances remaining on the skin surface before collecting tip blood of a fingertip, thereby avoiding affecting detection accuracy.
Specifically, the skin disinfectant comprises the following components: a disinfectant; nonionic glycolipid compounds; an organic solvent.
Wherein the disinfectant is used for skin surface disinfection, in one embodiment the disinfectant may be a nonionic disinfectant, in particular the disinfectant may comprise one or a combination of two of parachlorometaxylenol and trichlorohydroxydiphenyl ether.
In one embodiment, the concentration of disinfectant may be 0.05 to 1.0% w/v, thereby ensuring a disinfecting effect.
The non-ionic disinfectant can effectively avoid the interference to blood test caused by the dissolution and ionization of non-volatile components remained on the skin after disinfection after contacting with blood sample.
The nonionic glycolipid compound is used as a biosurfactant, has extremely low CMC value besides solubilization, surface tension reduction and decontamination enhancement which are common to common synthetic surfactants, and can remarkably reduce the addition amount of the surfactant in a formula while meeting the corresponding efficacy, thereby maximally reducing the residue of the disinfectant on the skin after use.
In addition, it is also important that the high frequency use of skin disinfectants is not neglected in the case of skin irritation and problems such as dry skin and chapping caused by volatile solvents, and in some specific use scenarios, many users who need to take blood at high frequency, for example, type 2 diabetics may need to perform blood glucose test for up to 7 times in a day, so that at high use frequency, skin is easy to influence the barrier function and self-repairing function of skin due to skin dryness and chapping caused by irritation problems of disinfectants, and further increase the infection risk of users when peripheral blood is pricked, which is a vicious cycle.
The nonionic glycolipid compound has excellent skin-friendly and skin-care properties, so that the irritation of the disinfectant to skin is reduced, and the disinfectant solvent can be left on the skin surface after volatilization to help skin repair and has a moisturizing function. At the same time, the chemical stability of the skin does not interfere with the test even if a small amount of skin remains to be re-dissolved in the blood sample. In addition, the nonionic glycolipid compound also has excellent antibacterial and bacteriostatic properties, and has synergistic effect with main bactericidal components in the disinfectant, so that the bactericidal and bacteriostatic properties of the formula can be improved on one hand, and the content of the disinfectant can be reduced on the other hand.
In one embodiment, the non-ionic glycolipid compound may include one or more combinations of trehalose lipids, sophorolipids, mannitol erythritol lipids, amber-trehalose lipids, cellobiose lipids.
In one embodiment, the concentration of the nonionic glycolipid compound may be 0.02 to 1.4% w/v, thereby minimizing residues while ensuring cleaning and disinfecting effects.
The organic solvent may be a lower alcohol for dissolving the mixed disinfectant and the nonionic glycolipid compound.
In one embodiment, the organic solvent may include one or more combinations of ethanol, isopropanol, and n-propanol.
In one embodiment, the volume fraction of the organic solvent may be 40% to 65%, and the remaining solvent may be deionized water.
The following further explains the beneficial effects of the technical scheme of the present application in detail through specific examples.
Example 1:
a clean skin disinfectant consists of the following components: 0.25% w/v trichlorohydroxydiphenyl ether; 0.45% w/v sophorolipid; isopropanol 35% v/v; ethanol 20% v/v; water 45% v/v.
The use of sophorolipids in example 1 can significantly improve the killing and bacteriostasis properties of the disinfectant against pseudomonas aeruginosa. Meanwhile, sophorolipid with stronger cleaning capability in the glycolipid surfactant is adopted, so that the content of the surfactant can be reduced, and meanwhile, good antibacterial and antiviral properties can be kept.
Example 2:
a clean skin disinfectant consists of the following components: 0.25% w/v trichlorohydroxydiphenyl ether; 0.25% w/v sophorolipid; mannitol erythritol lipid 0.35% w/v; ethanol 35% v/v; 15% v/v isopropanol; water 50% v/v.
Example 2 the newly added mannitol erythrito ester compared with example 1 has good killing and antibacterial effect on gram positive bacteria. The sophorolipid, the mannose erythritol lipid and the trichlorohydroxydiphenyl ether are compounded, so that the sterilization efficiency and the antibacterial range of the disinfectant formula can be obviously improved, the lasting antibacterial capability is provided, and the disinfectant is mild and has no stimulation to skin. Meanwhile, the addition amount of the isopropanol in the formula can be reduced so as to reduce uncomfortable smell brought by the product in the use process.
Example 3:
a clean skin disinfectant consists of the following components: 0.25% w/v trichlorohydroxydiphenyl ether; 0.20% w/v sophorolipid; mannitol erythritol lipid 0.30% w/v; 0.30% w/v cellobiose; ethanol 50% v/v; water 50% v/v.
Example 3 has newly increased cellobiose lipid relative to example 2, the addition of cellobiose lipid has improved the antifungal activity of disinfectant obviously, thus has endowed the products with very extensive antibacterial, antifungal, antiviral properties; meanwhile, the relatively high surfactant content ensures the decontamination performance, and simultaneously completely avoids the use of isopropanol, so that the skin disinfectant combination has extremely mild characteristics.
Example 4:
a clean skin disinfectant consists of the following components: 0.25% w/v trichlorohydroxydiphenyl ether; trehalose lipid 0.60% w/v; ethanol 35% v/v; 25% v/v isopropyl alcohol; water 40% v/v.
Example 5:
a clean skin disinfectant consists of the following components: 0.05% w/v of parachlorometaxylenol; trehalose lipid 0.60% w/v; 0.30% w/v sophorolipid; ethanol 35% v/v; isopropanol 20% v/v; water 45% v/v.
Example 6:
a clean skin disinfectant consists of the following components: 1.0% w/v trichlorohydroxydiphenyl ether; amber-trehalose lipid 0.02% w/v; ethanol 55% v/v; water 45% v/v.
Effect example 1: microbial killing Performance test
The skin disinfectants of example 1 and example 2 were subjected to a microbiocidal test by quantitative detection using a suspension method, and the following detection results were obtained with reference to the general requirements for skin disinfectants of "disinfection technical Specification" (2002 edition) and GB 27951:
as shown in the data of the table above, the skin disinfectants of examples 1 and 2 can rapidly kill staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and candida albicans, the average killing log value of microorganisms is more than 5.00 in 30 seconds, and the sterilization rate is more than or equal to 99.9999%.
Further, the skin disinfectant of example 1 was evaluated by a disinfection field test with reference to "disinfection technical Specification" (2002 edition), the skin disinfectant was allowed to act for 1min, and the test was repeated 30 times, and the test results are shown in the following table.
As shown in the table above, in 30 experiments, the average killing logarithmic value of example 1 to natural bacteria within 1min reaches more than 1.23, wherein the maximum value reaches 1.95, and the sterilizing effect is excellent.
Effect example 2: skin irritation test
Skin irritation tests were performed on the skin disinfectants of examples 1 and 2 with reference to the disinfection technical Specification (2002 edition).
The specific test process comprises the following steps: selecting a rabbit with intact skin, wherein one rabbit is used as an experimental group, the other rabbit is used as a control group, the experimental group is used as an experimental region after the back spine part region of the rabbit is dehaired, the experimental region of the experimental group is coated with the skin disinfectant of the example 1 and the example 2, the experimental region is covered by a layer of non-stimulated plastic film or oilpaper and then is fixed by a non-stimulated adhesive tape, and the experimental region of the control group adopts blank control.
After the end of the experiment, the residual test substance was removed with warm water or a non-irritating solvent, and the skin local reaction was observed 1h, 24h and 48h thereafter to judge skin irritation.
Through the above experiments, the skin disinfectants of example 1 and example 2 were both non-irritating.
Effect example 3: decontamination performance experiment
Since there is no standard detergency test method in the field of no-wash disinfectants at present, according to one application scenario where the skin disinfectant of the present application is used as a carrier disinfectant (disinfectant wet wipe), the detergency of the skin disinfectants of examples 1 to 4 was measured while 75% alcohol was used as a comparative example, with reference to the detergency measurement method described in annex B of GB/T27728-2011 wet wipe.
The specific experimental process is as follows:
standard artificial oil stain is uniformly coated on a stainless steel metal test piece, the stainless steel test piece and the stainless steel test piece are respectively put into test solutions, then the test solutions are subjected to swabbing for 3min by a swabbing machine, and then the test solutions are dried and cooled, and the detergency is detected, so that the data in the following table are obtained.
Disinfectant agent Detergency power
Example 1 9.4％
Example 2 11.5％
Example 3 17.1％
Example 4 13.8％
Comparative example (75% alcohol) 1.4％
As shown in the above table, the skin disinfectants of examples 1 to 4 all had detergency more than 9.4%, which is far superior to conventional disinfectant alcohol, wherein the skin disinfectants of example 3 had detergency more than 12 times that of 75% alcohol.
The previous description of the disclosure is provided to enable any person skilled in the art to make or use the disclosure. Various modifications to the disclosure will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other variations without departing from the scope of the disclosure. Thus, the disclosure is not limited to the examples and designs described herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (9)

1. A cleaning skin disinfectant, comprising the following components:
a disinfectant;
nonionic glycolipid compounds;
an organic solvent.
2. A cleaning skin disinfectant according to claim 1, wherein the disinfectant has a concentration of 0.05 to 1.0% w/v and the nonionic glycolipid compound has a concentration of 0.02 to 1.4% w/v.
3. A cleaning skin disinfectant according to claim 1, wherein the volume fraction of the organic solvent is 40% to 65%.
4. The cleansing skin disinfectant according to claim 1, characterized in that the nonionic glycolipid compound comprises one or more combinations of trehalose lipids, sophorolipids, mannohydroerythritol lipids, amber-trehalose lipids, cellobiose lipids.
5. The cleansing skin disinfectant according to claim 4, characterized in that the nonionic glycolipid compound comprises a combination of sophorolipids, mannohydroerythritol lipids, cellobiose lipids.
6. The cleansing skin disinfectant according to claim 5, wherein the weight ratio of the sophorolipids, mannosyl erythritol lipids, cellobiose lipids is 2:3:3.
7. the cleansing skin disinfectant according to claim 1, wherein the disinfectant comprises one or a combination of two of parachlorometaxylenol and trichlorohydroxydiphenyl ether.
8. The cleansing skin disinfectant according to claim 1, wherein the organic solvent includes one or more combinations of ethanol, isopropyl alcohol and n-propyl alcohol.
9. Use of a cleaning skin disinfectant as claimed in any one of claims 1 to 8 for disinfecting and cleaning the skin before blood collection at the tip of a fingertip.
CN202310480761.0A 2023-04-28 2023-04-28 Clean skin disinfectant and application thereof Pending CN116509827A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109536296A (en) * 2018-12-29 2019-03-29 陈欣欣 A kind of baby's antibacterial biological detergent and preparation method thereof
CN111529478A (en) * 2020-06-16 2020-08-14 广东添乐化妆品有限公司 Moisturizing hand-washing-free disinfectant and preparation method thereof
CN114621823A (en) * 2022-03-30 2022-06-14 南京军科超材科技有限公司 Multifunctional cleaning disinfectant and preparation method thereof
CN115895795A (en) * 2022-12-26 2023-04-04 媞颂日化用品(广州)有限公司 Cleaning composition containing biosurfactant and preparation method and application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109536296A (en) * 2018-12-29 2019-03-29 陈欣欣 A kind of baby's antibacterial biological detergent and preparation method thereof
CN111529478A (en) * 2020-06-16 2020-08-14 广东添乐化妆品有限公司 Moisturizing hand-washing-free disinfectant and preparation method thereof
CN114621823A (en) * 2022-03-30 2022-06-14 南京军科超材科技有限公司 Multifunctional cleaning disinfectant and preparation method thereof
CN115895795A (en) * 2022-12-26 2023-04-04 媞颂日化用品(广州)有限公司 Cleaning composition containing biosurfactant and preparation method and application thereof

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