CN116492274A - Ointment with skin whitening and repairing functions - Google Patents

Abstract

The invention discloses an ointment with skin whitening and repairing functions, which is prepared from the following raw materials in parts by weight: 20-30 parts of prepared rehmannia root, 15-25 parts of astragalus root, 18-22 parts of Chinese angelica, 10-20 parts of bupleurum, 15-25 parts of nutgrass galingale rhizome, 8-12 parts of fingered citron, 15-25 parts of poria cocos, 10-20 parts of coix seed, 10-20 parts of white hyacinth bean, 8-15 parts of cimicifuga rhizome, 10-20 parts of cassia twig and 10-20 parts of platycodon root, and discloses a preparation method and application thereof.

Description

Ointment with skin whitening and repairing functions

Technical Field

The invention relates to the technical field of daily chemical products, in particular to an ointment with a skin whitening and repairing function, and in particular relates to an application of removing chloasma.

Background

Chloasma is a yellow-brown pigmented spot on the face caused by a variety of factors, and is not an independent disease, but is a subtype of skin darkening disease. Interpretation of traditional Chinese medicine: the chloasma on the face is caused by qi deficiency and blood stasis caused by poor liver and kidney of a patient, so that toxin cannot be excreted, and in-vivo toxin is deposited on the face to form chloasma. Western interpretation: the chloasma on the face is caused by the disorder or obstacle of hormone secretion in the body and a series of linkage reasons, the working and living pressure is high, the sun-proof work is not finished, and poor cosmetics are used, so that pigments are accumulated on the face, and the chloasma is finally formed.

In the aspect of traditional Chinese medicine, chloasma is related to yin-blood deficiency of human body, especially physiological characteristics of pregnant women, the chloasma cannot leave sufficient yin-blood of the body, and if the yin-blood deficiency possibly leads to skin diseases, so the traditional Chinese medicine has a theory of 'the women use blood as the basis'. The main etiology and pathogenesis of chloasma are related to kidney, liver and spleen, and also pulse and conception vessel, and the traditional Chinese medicine can regulate liver, spleen, kidney and qi and blood aiming at deficiency or insufficiency of viscera.

Modern medicine considers that chloasma generated during pregnancy is caused by microcirculatory blockage among tissue cells, cell lysis and death, melanin increase, facial epidermis is thinnest, capillaries are most abundant, pigmentation is most easily formed, pigmentation is mainly on the basal epidermis, melanin particles are obviously increased, more melanin exists in more serious dermal melanocytes, and compared with normal skin, melanin formation and activity of the melanin particles are different in growth.

Disclosure of Invention

The invention aims at overcoming the defects of the prior art and provides an ointment with skin whitening and repairing functions, and a preparation method and application thereof.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

an ointment with skin whitening and repairing functions is prepared from the following raw materials in parts by weight: 20-30 parts of prepared rhizome of rehmannia, 15-25 parts of astragalus membranaceus, 18-22 parts of angelica sinensis, 10-20 parts of radix bupleuri, 15-25 parts of rhizoma cyperi, 8-12 parts of fingered citron, 15-25 parts of poria cocos, 10-20 parts of coix seed, 10-20 parts of white hyacinth bean, 8-15 parts of rhizoma cimicifugae, 10-20 parts of cassia twig and 10-20 parts of platycodon grandiflorum.

The ointment is prepared from the following raw materials in parts by weight: 25 parts of prepared rhizome of rehmannia, 20 parts of astragalus, 20 parts of angelica, 15 parts of radix bupleuri, 20 parts of nutgrass galingale rhizome, 10 parts of fingered citron, 20 parts of poria cocos, 15 parts of coix seed, 15 parts of white hyacinth bean, 12 parts of cimicifuga rhizome, 15 parts of cassia twig and 15 parts of platycodon root.

The ointment is prepared from the following raw materials in parts by weight: 20 parts of prepared rhizome of rehmannia, 25 parts of astragalus, 18 parts of angelica, 20 parts of radix bupleuri, 15 parts of nutgrass galingale rhizome, 12 parts of fingered citron, 15 parts of poria cocos, 20 parts of coix seed, 10 parts of white hyacinth bean, 15 parts of cimicifuga rhizome, 10 parts of cassia twig and 20 parts of platycodon root.

The ointment is prepared from the following raw materials in parts by weight: 30 parts of prepared rhizome of rehmannia, 15 parts of astragalus, 22 parts of angelica, 10 parts of radix bupleuri, 25 parts of nutgrass galingale rhizome, 8 parts of fingered citron, 25 parts of poria cocos, 10 parts of coix seed, 20 parts of white hyacinth bean, 8 parts of cimicifuga rhizome, 20 parts of cassia twig and 10 parts of platycodon root.

The ointment is prepared according to the conventional preparation method of traditional Chinese medicines.

The ointment is applied to the preparation of cosmetics for treating chloasma.

The chloasma refers to chloasma generated during pregnancy, and the syndrome of deficiency of qi and blood is seen.

The preparation method of the ointment comprises the following steps:

(1) Taking the raw materials: soaking radix rehmanniae Preparata, radix astragali, radix Angelicae sinensis, bupleuri radix, rhizoma Cyperi, fructus Citri Sarcodactylis, poria, coicis semen, semen lablab album, cimicifugae rhizoma, ramulus Cinnamomi, and radix Platycodi in water for 1 hr, adding 10 times of water, decocting for 1-2 hr, and filtering to obtain first residue and first filtrate;

(2) Adding 8 times of water into the first filter residue, decocting for 1-2h, and filtering to obtain second filter residue and second filtrate;

(3) Mixing the first filtrate and the second filtrate, concentrating to a density of 1.0-1.3,2-8deg.C, standing for 40-60 hr to separate layers, and collecting supernatant to obtain the Chinese medicinal extractive solution;

(4) Adding the Chinese medicinal extractive solution into oil phase prepared from stearic acid, glyceryl monostearate, stearyl alcohol and liquid paraffin, sterilizing, and packaging to obtain the ointment.

The radix rehmanniae Preparata is rhizome of rehmanniae radix or rehmanniae radix of Scrophulariaceae, and is prepared by steaming and sun drying. Nourishing yin and tonifying blood. For treating deficiency of yin and blood, debility of waist and knee, fatigue, bone steaming, spermatorrhea, metrorrhagia, menoxenia, diabetes, scanty urine, deafness, and dizziness.

The radix astragali is root of Astragalus mongholicus Astragalus memeranaceus (Fisch.) bge.var. Mongholicus (bge.) Hsiao or Astragalus membranaceus A.membrane aceus (Fisch.) bge. Has effects of invigorating spleen, invigorating middle warmer, invigorating yang, consolidating superficial resistance, promoting urination, removing toxic substances, and promoting granulation. It is indicated for spleen qi deficiency, lung qi deficiency, spontaneous perspiration due to qi deficiency, qi and blood deficiency, and sores and ulcers, or chronic ulcer.

Angelica sinensis is the dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels, umbelliferae. The main production of Gansu southeast is rich in Min county yield and good in quality, and the second is Yunnan, sichuan, shaanxi, hubei and other provinces, which are all cultivated. Has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. It is commonly used for sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, rheumatalgia, traumatic injury, carbuncle, ulcer, and constipation due to intestinal dryness. The wine angelica can promote blood circulation and promote menstruation. Can be used for treating amenorrhea dysmenorrhea, rheumatalgia, traumatic injury.

The Bupleurum is dry root of Bupleurum scorzonerifolium of Umbelliferae or Bupleurum scorzonerifolium. Collected in spring and autumn, removed stem and leaf and silt, and dried. Bupleuri radix is a commonly used exterior-releasing herb. The herb with the name of fumigating, mountain vegetable, mushroom grass and firewood is bitter in taste and slightly cold in nature, and enters liver and gallbladder meridians. Has the effects of relieving exterior and interior syndrome, soothing liver and raising yang. Can be used for treating common cold, fever, cold and heat, malaria, liver depression, qi stagnation, chest pain, rectocele, uterine prolapse, and menoxenia.

The rhizoma Cyperi is dried rhizome of Cyperus rotundus L of Cyperaceae. Plucking in autumn, singeing, boiling in boiling water, or steaming, sun drying, or sun drying directly. Pungent, slightly bitter, slightly sweet, and flat. It enters liver, spleen and triple energizer meridians. Liver soothing, qi stagnation relieving, qi regulating, middle energizer regulating, menstruation regulating and pain relieving. Can be used for treating liver depression, qi stagnation, chest and hypochondrium distending pain, hernia pain, breast distending pain, spleen and stomach qi stagnation, epigastric fullness and distention pain, menoxenia, amenorrhea and dysmenorrhea.

The fructus Citri Sarcodactylis is a dried fruit of Citrus media Lvar. Harvesting while the autumn fruits are not yet turned yellow or turn yellow, cutting into slices, and sun-drying or low-temperature drying. Pungent, bitter and sour in flavor and warm in nature. It enters liver, spleen, stomach and lung meridians. Liver soothing, qi regulating, stomach harmonizing, pain relieving, dampness eliminating and phlegm eliminating effects. Can be used for treating stagnation of liver-qi and stomach-qi, distending pain in chest and hypochondrium, gastric cavity distention and fullness, anorexia, emesis, cough and excessive phlegm.

Poria is the dry sclerotium of Wolf, a fungus of the Polyporaceae family, poria cocos (Schw.) co. Digging for more than 7-9 months, removing sediment after digging out, piling up for "sweating", spreading out and airing until the surface is dry, then "sweating", repeating for several times until most of internal moisture is lost, and drying in the shade, namely "Fuling Zhi"; or cutting fresh Poria into pieces according to different parts, and drying in the shade, which are called "Poria block" and "Poria tablet", respectively. Sweet and light in taste and neutral in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and excrete dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm retention, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

The Coicis semen is dry mature seed of Coix lacryma-jobi L.var. Harvesting plants in autumn when the fruits are ripe, sun-drying, peeling the fruits, sun-drying, removing the hulls, the yellow brown seed coats and impurities, and collecting kernels. Sweet and bland in flavor and cool in nature. Enter spleen, stomach and lung meridians. Has effects of promoting diuresis, removing dampness, invigorating spleen, relieving diarrhea, removing arthralgia, expelling pus, removing toxic substances, and resolving hard mass. Can be used for treating edema, tinea pedis, dysuria, spleen deficiency diarrhea, damp arthralgia, pulmonary abscess, and appendicitis; warts, cancers.

White hyacinth bean is white seed of hyacinth bean of Leguminosae. Picking up mature pods before and after winter, sun drying, threshing seeds, and sun drying. The main functions are as follows: strengthening spleen and regulating stomach, relieving summer heat and eliminating dampness. For vomiting and diarrhea due to summer-heat and dampness, vomiting and adverse flow of qi due to spleen deficiency, diarrhea due to anorexia, water retention and diabetes, leukorrhagia, infantile malnutrition. (1) The miscellaneous records: and main and middle and lower qi. (2) Drug Property theory (L): is mainly used for resolving all grass and wood toxins, is raw for chewing and is decocted for taking. (3) Meng: for treating cholera, it is used by vinegar. (4) Japanese Sunji (Japanese Subtu) grass: supplement the five zang organs. (5) The book of materia medica drawing channel: it can promote the circulation of wind and qi, kill alcohol toxicity and dispel tetrodotoxin in women's lower band. (6) Yunnan Ben Cao (materia Medica): for infantile malnutrition due to spleen and stomach weakness, regurgitation, vomiting, chronic diarrhea, food stagnation, and lump. (7) Essence of the product (Hui Jing): relieving summer heat and regulating middle warmer. (8) Compendium, compendium: stop diarrhea, remove summer heat, warm spleen and stomach, remove damp-heat, and stop thirst. (9) Medical mirror about meeting ]: raw materials are used for clearing summer-heat and nourishing stomach, and stir-baked for strengthening spleen and checking diarrhea.

Cimicifuga rhizome alias: longan root, zhou Ma, hole root, rhizome of Cimicifuga major leaf of Cimicifuga genus of Ranunculaceae family, and Cimicifuga racemosa or cimicifuga rhizome. Perennial herbs are 1-2 m high. The rootstalk is irregular block-shaped, multi-branched, nodular, with hole-shaped stem mark, black brown surface and many and fine fibrous roots. The stems stand upright and have soft and soft hairs. She Husheng the basal leaves and the lower stem leaves are two to three lupin-shaped compound leaves; the small blades are oval or needle-shaped, the edges of the small blades are provided with coarse saw teeth, the leaves are green, the backs of the small blades are grey, and both sides of the small blades are provided with short soft hairs. Flowers are small, yellow and white, and are arranged into conical inflorescences with the length of 112.5px and grow on the tops of branches; sepal 5 pieces with wool at the edge; 2 degenerated stamens, and 2 pieces of degenerated stamens at the front end; a plurality of developmental stamens; 9 months, fruits are dense, short and soft, long and round and slightly flat, preferably dug in autumn, sediment is removed, and when the fruits are dried, the roots are burnt or removed and dried for later use. Is used in hillside grass, lin Bian, mountain roadside and shrubs. Mainly produced in Liaoning, jilin, heilongjiang, hebei, shanxi, sichuan, qinghai and other provinces. Pungent, sweet and slightly cold. It enters lung, spleen, large intestine and stomach meridians. Promoting eruption, clearing heat and detoxicating, and raising yang. Qi syndrome pestilence, headache, cold and heat, sore throat, aphtha and macula; sinking of middle-jiao, chronic diarrhea, rectocele, metrorrhagia, leukorrhagia, and metrostaxis; carbuncle, swelling and sore.

Ramulus Cinnamomi belongs to Cinnamomum, lauraceae, and is a medium-sized arbor; annual branches are cylindrical, the terminal buds are in a scale wide oval shape, green leaves grow mutually, and the shape of each annual branch is oblong to be nearly in a needle shape; white flower, about 4.5mm long; the fruits are oval, black and purple when ripe, and have no hair; flowering period is 6-8 months, and fruit period is 10-12 months. Mainly produced in Guangxi, guangdong and Yunnan provinces. Cutting off tender branch in spring and summer, sun drying or drying in shade, and cutting into slices or segments. Pungent, sweet and warm. It enters heart, lung and bladder meridians. Has effects of inducing sweat, relieving muscle, warming and activating meridian, supporting yang, activating qi-flowing, and calming the pulse. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation, etc.

Radix Platycodi is dry root of radix Platycodi Platycodon grandiflorus (Jacq.) A.Dc. Collected in spring and autumn, cleaned, removed fibrous root, peeled or not peeled, and dried. The plant is planted on a mountain grass slope, a forest edge or cultivated. Distributed throughout regions of the country. Has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, pulmonary abscess, and pus discharge.

The invention has the advantages that:

1. the traditional Chinese medicine theory considers that the chloasma is caused during pregnancy, namely liver qi stagnation causes facial blood stasis; secondly, the spleen and stomach are weak, qi and blood can not moisten the face, and damp heat rises the face to form spots; thirdly, kidney yang is deficient, yang is dispersed, and blood stasis forms chloasma. After pregnancy, androgens secreted by the placenta are increased, so symmetric chloasma often appears on cheeks of pregnant women, but spots of most people naturally decrease or disappear after the androgens are secreted and normal after production. The traditional Chinese medicine is often treated by soothing liver and clearing damp and heat, but does not have good effect, the invention considers that chloasma is closely related to liver, spleen and kidney, but qi and blood cannot nourish the face, and is a main pathogenesis, particularly qi and blood nourish the uterus during pregnancy, so that the deficiency of qi and blood of the viscera is easy to cause chloasma, pregnant women are clinically seen, the pregnant women start 2-5 months after pregnancy, the chloasma symmetrically occurs on the face, particularly two cheeks, forehead, nose, lips, chin and the like; the skin loss is pale brown to dark brown, pale black patches, and has pale complexion, dizziness, listlessness, debilitation, pale lips and feet, pale tongue, and thready and weak pulse. Women's menstruation, pregnancy, production, lactation and the like consume more blood, which causes deficiency of qi and blood, blood deficiency cannot nourish the upper part of the body, blood weakness cannot bloom, qi deficiency cannot move blood, and blood stagnation. The invention mainly supplements qi and blood, has the functions of soothing liver and treating chloasma, strengthening spleen and resolving dampness, and can more effectively solve the clinical symptoms of patients with chloasma due to deficiency of qi and blood by matching with the promotion of middle-jiao qi, and has the function of whitening and repairing skin.

2. The invention optimizes the raw materials and the weight proportion thereof so as to achieve the optimal clinical curative effect. The research results show that the mixture ratio can improve clinical symptoms of patients with chloasma due to deficiency of qi and blood, and has the skin whitening and repairing functions.

3. The raw material medicines of the invention conform to the compatibility principle of monarch, minister, assistant and guide: the invention takes rehmannia root, astragalus root, chinese angelica root, bupleurum root, nutgrass galingale rhizome and fingered citron to nourish uterus, so that the deficiency of qi and blood of the viscera can not be nourished in the face, and the female is always good and bad in mood during pregnancy, and is easy to cause stagnation of liver qi; for threatened abortion caused by deficiency of both qi and blood during pregnancy, cimicifugae rhizoma, ramulus Cinnamomi and radix Platycodi are used as adjuvant and guiding drugs. The invention has strict formula and wide application range, and has the functions of treating chloasma caused by deficiency of qi and blood and whitening and repairing skin.

Detailed Description

The invention is further described below in conjunction with the detailed description. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention. Further, it is understood that various changes and modifications of the present invention may be made by those skilled in the art after reading the description of the present invention, and that such equivalents are intended to fall within the scope of the claims appended hereto.

Example 1

Taking 25g of prepared rhizome of rehmannia, 20g of astragalus, 20g of angelica, 15g of radix bupleuri, 20g of nutgrass galingale rhizome, 10g of fingered citron, 20g of poria cocos, 15g of coix seed, 15g of white hyacinth bean, 12g of cimicifuga rhizome, 15g of cassia twig and 15g of balloonflower root,

the preparation method comprises the following steps:

(1) Taking the raw materials: soaking radix rehmanniae Preparata, radix astragali, radix Angelicae sinensis, bupleuri radix, rhizoma Cyperi, fructus Citri Sarcodactylis, poria, coicis semen, semen lablab album, cimicifugae rhizoma, ramulus Cinnamomi, and radix Platycodi in water for 1 hr, adding 10 times of water, decocting for 1 hr, and filtering to obtain first residue and first filtrate;

(2) Adding 8 times of water into the first filter residue, decocting for 2 hours, and filtering to obtain a second filter residue and a second filtrate;

(3) Mixing the first filtrate and the second filtrate, concentrating to a density of 1.0,8 ℃, standing for 40h to separate layers, and obtaining supernatant as the traditional Chinese medicine extracting solution;

(4) Adding the Chinese medicinal extractive solution into oil phase prepared from stearic acid, glyceryl monostearate, stearyl alcohol and liquid paraffin, sterilizing, and packaging to obtain the ointment.

Example 2

Taking 20g of prepared rhizome of rehmannia, 25g of astragalus, 18g of angelica, 20g of radix bupleuri, 15g of nutgrass galingale rhizome, 12g of fingered citron, 15g of poria cocos, 20g of coix seed, 10g of white hyacinth bean, 15g of cimicifuga rhizome, 10g of cassia twig and 20g of balloonflower root,

the preparation method comprises the following steps:

(1) Taking the raw materials: soaking radix rehmanniae Preparata, radix astragali, radix Angelicae sinensis, bupleuri radix, rhizoma Cyperi, fructus Citri Sarcodactylis, poria, coicis semen, semen lablab album, cimicifugae rhizoma, ramulus Cinnamomi, and radix Platycodi in water for 1 hr, adding 10 times of water, decocting for 2 hr, and filtering to obtain first residue and first filtrate;

(2) Adding 8 times of water into the first filter residue, decocting for 1h, and filtering to obtain a second filter residue and a second filtrate;

(3) Mixing the first filtrate and the second filtrate, concentrating to a density of 1.3,2 ℃, standing for 60 hours to separate layers, and obtaining supernatant fluid, namely the traditional Chinese medicine extract;

(4) Adding the Chinese medicinal extractive solution into oil phase prepared from stearic acid, glyceryl monostearate, stearyl alcohol and liquid paraffin, sterilizing, and packaging to obtain the ointment.

Example 3

Taking 30g of prepared rhizome of rehmannia, 15g of astragalus, 22g of angelica, 10g of radix bupleuri, 25g of nutgrass galingale rhizome, 8g of fingered citron, 25g of poria cocos, 10g of coix seed, 20g of white hyacinth bean, 8g of cimicifuga rhizome, 20g of cassia twig and 10g of balloonflower root,

the preparation method comprises the following steps:

(1) Taking the raw materials: soaking radix rehmanniae Preparata, radix astragali, radix Angelicae sinensis, bupleuri radix, rhizoma Cyperi, fructus Citri Sarcodactylis, poria, coicis semen, semen lablab album, cimicifugae rhizoma, ramulus Cinnamomi, and radix Platycodi in water for 1 hr, adding 10 times of water, decocting for 2 hr, and filtering to obtain first residue and first filtrate;

(2) Adding 8 times of water into the first filter residue, decocting for 1h, and filtering to obtain a second filter residue and a second filtrate;

(3) Mixing the first filtrate and the second filtrate, concentrating to density of 1.2, standing at 5deg.C for 50 hr to separate layers, and collecting supernatant to obtain the Chinese medicinal extractive solution;

(4) Adding the Chinese medicinal extractive solution into oil phase prepared from stearic acid, glyceryl monostearate, stearyl alcohol and liquid paraffin, sterilizing, and packaging to obtain the ointment.

Example 4

Preparation of clinical observation data samples: clinical test samples were prepared as in example 1 above, with a specification of 10 g/count.

General data: 50 patients are outpatient patients with the clinic from 5 months of 2021 to 8 months of 2022. The Chinese medicinal composition accords with the symptom of chloasma during pregnancy, and is characterized in that chloasma symmetrically occurs on the face, and particularly, the two cheeks, the forehead, the nose, the lips, the chin and the like are common; the skin loss is pale brown to dark brown, pale black patches, and has pale complexion, dizziness, listlessness, debilitation, pale lips and feet, pale tongue, and thready and weak pulse. No infection, no allergy to the medicine and no mental abnormality. Other skin diseases and allergic diseases are excluded. Those who did not use the same type of drug prior to treatment, and those who were not undergoing other similar type of drug trials.

Exclusion criteria: 1. the diagnosis and inclusion standard of chloasma are not met; does not meet the inclusion standard of chloasma; 2. has the effects of combined infection, anaphylaxis to the medicine and mental abnormality. 3. According to the judgment of researchers, other medical histories which reduce the possibility of entering groups or complicate the entering groups, such as frequent change of working environment, are easy to cause the condition of losing access; or subjects who are participating in other drug clinical studies.

Treatment of chloasma patients: the face is dipped with the sterile cotton swab for external application, the ointment is applied for thirty minutes every time for 2 times, other skin care products and medicines with special curative effects are stopped during the treatment period, and one month is a treatment course. The patients are informed to keep the mood smooth, avoid excessive anxiety and overstrain, and avoid sunlight irradiation as much as possible, and eat less foods containing pigment such as soy sauce, pickles, cigarettes, wine, coffee, etc., and are forbidden to eat spicy foods.

And (3) observing curative effect: the standard of curative effect refers to the guidelines of clinical research on new Chinese medicine. Basic cure: (1) the visual stain area resolved by more than 90%, the color was essentially lost, and no visible stain was visible to the naked eye 1 meter away. (2) The index of decrease after treatment is more than or equal to 0.8 by the evaluation method. The effect is shown: (1) the visual stain area resolved by more than 60% and the color was visibly lighter. (2) The index of decrease after treatment is more than or equal to 0.5 by the evaluation method. Improvement: (1) the visual stain area resolved by more than 30% and the color was pale. (2) The index of decrease after treatment is more than or equal to 0.3 by the evaluation method. Invalidation: (1) the visual stain area resolved less than 30% with no apparent color change. (2) The index of decrease after treatment is more than or equal to 0 by the evaluation method.

Calculation formula (nimodipine method): [ (pre-treatment integral-post-treatment integral)/pre-treatment integral ] ×100%.

Treatment results: 50 cases were each reviewed immediately after 1 course of treatment was completed. Results: the medicine is used for curing 12 cases, 17 cases with obvious effect, 18 cases with effective effect, 3 cases with ineffective effect, and the total effective rate is 96 percent.

Typical case 1: zhang Mou female, 28 years old, clinical diagnosis of pregnancy chloasma, dipping the face with the sterile cotton swab for external application, taking the ointment of the invention for 4 times daily, 50 minutes each time in the morning and evening, stopping using other skin care products and medicines with special curative effects during the treatment period, and fading the color of chloasma after three months, recovering, thereby having the skin whitening and repairing functions.

Typical case 2: hong Mou female 25 years old, clinical diagnosis is that the chloasma is pregnancy, the face is dipped with the sterile cotton swab for external application, the ointment is applied for 3 times a day, 60 minutes a day and a night, other skin care products and medicines with special curative effects are stopped during treatment, and after two months, the chloasma is light in color and healed, and the skin whitening and repairing functions are realized.

Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (8)

1. An ointment with skin whitening and repairing functions is characterized by being prepared from the following raw materials in parts by weight: 20-30 parts of prepared rhizome of rehmannia, 15-25 parts of astragalus membranaceus, 18-22 parts of angelica sinensis, 10-20 parts of radix bupleuri, 15-25 parts of rhizoma cyperi, 8-12 parts of fingered citron, 15-25 parts of poria cocos, 10-20 parts of coix seed, 10-20 parts of white hyacinth bean, 8-15 parts of rhizoma cimicifugae, 10-20 parts of cassia twig and 10-20 parts of platycodon grandiflorum.

2. The ointment according to claim 1, wherein the ointment is prepared from the following raw materials in parts by weight: 25 parts of prepared rhizome of rehmannia, 20 parts of astragalus, 20 parts of angelica, 15 parts of radix bupleuri, 20 parts of nutgrass galingale rhizome, 10 parts of fingered citron, 20 parts of poria cocos, 15 parts of coix seed, 15 parts of white hyacinth bean, 12 parts of cimicifuga rhizome, 15 parts of cassia twig and 15 parts of platycodon root.

3. The ointment according to claim 1, wherein the ointment is prepared from the following raw materials in parts by weight: 20 parts of prepared rhizome of rehmannia, 25 parts of astragalus, 18 parts of angelica, 20 parts of radix bupleuri, 15 parts of nutgrass galingale rhizome, 12 parts of fingered citron, 15 parts of poria cocos, 20 parts of coix seed, 10 parts of white hyacinth bean, 15 parts of cimicifuga rhizome, 10 parts of cassia twig and 20 parts of platycodon root.

4. The ointment according to claim 1, wherein the ointment is prepared from the following raw materials in parts by weight: 30 parts of prepared rhizome of rehmannia, 15 parts of astragalus, 22 parts of angelica, 10 parts of radix bupleuri, 25 parts of nutgrass galingale rhizome, 8 parts of fingered citron, 25 parts of poria cocos, 10 parts of coix seed, 20 parts of white hyacinth bean, 8 parts of cimicifuga rhizome, 20 parts of cassia twig and 10 parts of platycodon root.

5. The ointment of any one of claims 1-4, wherein the ointment is prepared according to conventional methods of preparing traditional Chinese medicines.

6. The use of an ointment according to any one of claims 1 to 4 for the preparation of cosmetics for the treatment of chloasma.

7. The ointment of claim 1, wherein the preparation method comprises the steps of:

(1) Taking the raw materials: soaking radix rehmanniae Preparata, radix astragali, radix Angelicae sinensis, bupleuri radix, rhizoma Cyperi, fructus Citri Sarcodactylis, poria, coicis semen, semen lablab album, cimicifugae rhizoma, ramulus Cinnamomi, and radix Platycodi in water for 1 hr, adding 10 times of water, decocting for 1-2 hr, and filtering to obtain first residue and first filtrate;

(2) Adding 8 times of water into the first filter residue, decocting for 1-2h, and filtering to obtain second filter residue and second filtrate;

(3) Mixing the first filtrate and the second filtrate, concentrating to a density of 1.0-1.3,2-8deg.C, standing for 40-60 hr to separate layers, and collecting supernatant to obtain the Chinese medicinal extractive solution;

(4) Adding the Chinese medicinal extractive solution into oil phase prepared from stearic acid, glyceryl monostearate, stearyl alcohol and liquid paraffin, sterilizing, and packaging to obtain the ointment.

8. The use of the ointment according to claim 6, wherein the chloasma is chloasma generated during pregnancy, and the syndrome of deficiency of qi and blood.