CN116474014B - Traditional Chinese medicine composition for treating chicken histomonas and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chicken histomonas and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine compositions, and in particular discloses a traditional Chinese medicine composition for treating chicken histomonas and a preparation method thereof. The traditional Chinese medicine composition provided by the invention comprises the following components in parts by weight: 1-10 parts of fructus ulmi concentrated solution, 1-10 parts of fine She Awei, 1-10 parts of garden balsam stem root, 1-6 parts of pericarpium Granati, 0.5-1 part of dry paint and 1-5 parts of carpesium. The invention effectively solves the technical problems that the medicine for treating chicken histomonas has long treatment period, generates a certain degree of drug resistance after long-time treatment, is easy to generate drug residues and causes other diseases through the compatibility of the monarch drugs, the minister drugs, the assistant drugs and the guide drugs, the components of the traditional Chinese medicine composition are safe, the toxic and side effects are small, and the effect for treating chicken histomonas is remarkable.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, and in particular discloses a traditional Chinese medicine composition for treating chicken histomonas and a preparation method thereof.
Background
Chicken histotrichomoniasis is a parasitic disease caused by turkey histomonas, and birds such as laying hens, broilers, turkeys and the like can be infected and developed, and the developed chickens only mainly develop the liver and cecum of the chickens, and the appearance of the chicken histomonas is represented as a cockscomb, so the chicken histomonas is also called as cecal hepatitis or blackhead disease. Different breeds and groups of chickens of a week age can become infected with the disease, and normally, the histomonas parasitic in the cecum of the diseased chicken can enter the body of the heterodera species and begin to multiply. After the heterospines in the intestinal tracts of the sick chickens excrete along with the feces to the outside of the body, after the healthy chickens ingest feed or drinking water polluted by the eggs of the nematode, the protozoa of the tissue trichomonas further reach the cecum and begin to proliferate in the interstitial space under the protection of the eggs of the nematode, and then enter the liver through the portal vein, so that damage is caused to the liver tissue and necrotic spot lesions are formed. The disease is mostly chronic, is extremely easy to cause mixed infection such as colibacillus, clostridium, coccidium and the like, has high incidence in summer with more mosquitoes, insects and flies, and has higher infection rate and incidence rate than cage-reared chickens in clinic.
After the chicken flock is infected with cecal hepatitis, the chicken flock usually shows lassitude, appetite decline, sleepiness, poor activity, water-like diarrhea, yellow feces, coal tar-like changes and the like, and after some mixed infection coccidiosis, the feces also carry blood. At present, the chicken histomonas disease is treated by adopting the dimetimidazole tablet, the treatment period is long, the long-time treatment can generate a certain degree of drug resistance, the drug residue is easy to generate, other diseases are caused, and the chicken raising industry is threatened greatly.
Disclosure of Invention
Aiming at the technical problems that in the prior art, the treatment period of the medicine for treating chicken histomonas is long, a certain degree of drug resistance can be generated after long-time treatment, and medicine residues are easy to generate to cause other diseases, the invention provides a traditional Chinese medicine composition for treating chicken histomonas and a preparation method thereof. The Chinese herbal medicine composition utilizes the monarch, minister, assistant and guide relation of medicines to quickly and effectively treat the sick chicken, has the advantages of difficult generation of drug resistance, little toxic and side effects, promotion of organism growth, enhancement of immune function, improvement of organism disease resistance and the like, and has remarkable effect in the aspect of treating chicken histomonas.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
in a first aspect, the invention provides a traditional Chinese medicine composition for treating chicken histomonas, which comprises the following components in parts by weight: 1-10 parts of fructus ulmi concentrated solution, 1-10 parts of fine She Awei, 1-10 parts of garden balsam stem root, 1-6 parts of pericarpium Granati, 0.5-1 part of dry paint and 1-5 parts of carpesium.
Compared with the prior art, the invention provides a traditional Chinese medicine composition for treating chicken histomonas, wherein fructus ulmi concentrate, fine She Awei and garden balsam stem root are used as monarch drugs, and pericarpium Granati, resina Toxicodendri and fructus Carpesii are used as ministerial drugs; the fructus ulmi is pungent in flavor, warm in nature, and capable of entering spleen and stomach channels, and has effects of killing parasites, removing food retention, dispelling cold, relieving diarrhea, dispelling pathogenic wind and removing dampness; the fine She Awei ingredients are bitter and pungent, warm in nature, have the effects of removing food retention and killing parasites, and can remove odor, break disease accumulation and lower down bad smell; the garden balsam stem root has sweet and pungent taste and warm nature, enters lung and liver meridians, contains garden balsam and garden balsam alcohol acetate, and has insecticidal effect; the pomegranate rind has sour and astringent taste, warm nature and good property, enters large intestine meridian, has the effects of astringing intestine to stop diarrhea, stopping bleeding, expelling parasites, expelling dysentery, killing parasites and the like, is easy to obtain, and has low cost; the dry lacquer has pungent taste and warm nature, enters liver and spleen channels, and has the effects of removing blood stasis, removing food retention, killing insects and the like; the carpopodium herb is bitter and pungent in flavor, has the effects of killing parasites, clearing heat and detoxicating, strengthening spleen and stomach, and the like, and enters spleen, stomach and liver channels.
The invention utilizes the synergistic compatibility of monarch drugs and ministerial drugs to effectively treat chicken suffering from chicken histomonas disease, has better curative effect, can avoid side effects of western medicines used for a long time, is not easy to generate drug resistance, promotes organism growth, enhances immune function and improves disease resistance of chicken.
Preferably, the traditional Chinese medicine composition for treating chicken histomonas disease further comprises the following components in mass: 1-5 parts of fried fructus quisqualis, 1-5 parts of radix scutellariae, 2-5 parts of herba pogostemonis, 1-5 parts of poria cocos, 0.5-2 parts of gypsum, 1-4 parts of radix ophiopogonis and 1-5 parts of rhizoma anemarrhenae.
The invention also takes the stir-fried fructus quisqualis, the baical skullcap root, the patchouli and the Indian buead as adjuvant drugs, and gypsum, dwarf lilyturf tuber and common anemarrhena rhizome as guiding drugs, thereby assisting the treatment effect of the monarch drugs and ministerial drugs.
Preferably, the traditional Chinese medicine composition for treating chicken histomonas comprises the following components in parts by weight: 3-8 parts of fructus ulmi concentrated solution, 3-7 parts of fine She Awei parts of garden balsam stem root, 3-9 parts of pomegranate rind, 2-4 parts of dried paint, 0.6-0.8 part of carpesium, 2-4 parts of stir-fried fructus quisqualis, 2-3 parts of radix scutellariae, 3-4 parts of herba pogostemonis, 2-3 parts of poria cocos, 1-1.5 parts of gypsum, 2-3 parts of radix ophiopogonis and 1.5-3 parts of rhizoma anemarrhenae.
Preferably, the preparation method of the fructus ulmi concentrated solution comprises the following steps:
step a, baking fructus ulmi at 55-65 ℃ and crushing to obtain fructus ulmi powder;
And b, reflux-extracting the fructus ulmi powder with an ethanol solution for 3-5 times, combining the extracting solutions, and concentrating to obtain a fructus ulmi concentrated solution.
Preferably, in the step a, the particle size of the fructus ulmi powder is 80 μm to 100 μm.
Preferably, in the step b, the mass concentration of the ethanol solution is 85% -95%.
Preferably, in the step b, the mass ratio of the fructus ulmi powder to the ethanol solution is 1:25-35.
Preferably, in the step b, the concentration temperature is 70-75 ℃ and the concentration time is 25-35 min.
The second aspect of the invention provides a preparation method of the traditional Chinese medicine composition for treating chicken histomonas, which comprises the following steps:
parching the dry paint until the dry paint is completely smoked, weighing other components except the fructus ulmi concentrated solution according to the designed proportion, uniformly mixing, crushing and sieving to obtain a first mixture;
adding deionized water into the first mixture, soaking for 2-3 h with small fire, boiling, decocting for 0.5-1 h at 75-80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
adding deionized water into the second mixture, decocting with slow fire, filtering, and discarding filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting for 1h to 1.5h at the temperature of 40 ℃ to 45 ℃ to obtain the traditional Chinese medicine composition for treating chicken histomonas.
Preferably, in the first step, the particle size of the first mixture is 200 μm to 300 μm.
Preferably, in the second step, the mass ratio of the deionized water to the first mixture is 10-12:1-1.2.
Preferably, in the third step, the mass ratio of the deionized water to the second mixture is 5-6:1-1.5.
Preferably, in the second step, the temperature of the small fire is 45-50 ℃.
Preferably, in the third step, the temperature of the slow fire is 60-70 ℃.
Preferably, in the third step, the time of the slow fire boiling is 0.5h-1h.
The third aspect of the invention provides a traditional Chinese medicine preparation for treating chicken histomonas, which comprises the traditional Chinese medicine composition for treating chicken histomonas.
Preferably, the traditional Chinese medicine preparation is in a suspension form.
In summary, the invention provides the traditional Chinese medicine composition for treating chicken histomonas and the preparation method thereof, and the traditional Chinese medicine composition utilizes the monarch, minister, assistant and guide compatibility of medicines to rapidly and effectively treat chicken with the histomonas.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating chicken histomonas, which comprises the following specific contents:
the traditional Chinese medicine composition comprises the following components in parts by weight: 6g of fructus ulmi concentrate, she Awei g of garden balsam stem root, 3g of pericarpium Granati, 0.6g of dry paint, 3g of carpesium, 2.5g of fried fructus quisqualis, 2g of radix scutellariae, 3g of herba pogostemonis, 3g of poria cocos, 1g of gypsum, 2g of radix ophiopogonis and 2g of rhizoma anemarrhenae;
The preparation method of the fructus ulmi concentrated solution comprises the following steps:
Step a, baking fructus ulmi at 55 ℃, and crushing to obtain 80 mu m fructus ulmi powder;
and b, reflux-extracting the fructus ulmi powder with 200mL of 90% ethanol for 4 times, combining the extracting solutions, and removing the solvent to obtain the fructus ulmi concentrated solution.
The traditional Chinese medicine composition is suspension, and the specific preparation method is as follows:
Parching the dry paint until the dry paint is completely smoked, uniformly mixing the dry paint with other components except the ulmus pumila concentrated solution according to a designed proportion, crushing and sieving to obtain a first mixture with the particle size of 300 mu m;
Adding 350mL of deionized water into the first mixture, soaking for 2 hours with low fire at 45 ℃, boiling, decocting for 0.5 hour with low fire at 80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
Adding 180mL of deionized water into the second mixture, decocting for 0.5h at 60 ℃ with slow fire, filtering, and removing filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting with low fire at 40 ℃ to obtain the traditional Chinese medicine composition.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating chicken histomonas, which comprises the following specific contents:
The traditional Chinese medicine composition comprises the following components in parts by weight: 8g of fructus ulmi concentrate, she Awei g of fine She Awei g of garden balsam stem root, 7g of pomegranate rind, 2g of dried lacquer, 2g of carpesium, 2g of fried fructus quisqualis, 2g of baical skullcap root, 4g of patchouli, 2g of Indian buead, 1.5g of gypsum, 3g of dwarf lilyturf tuber and 3g of common anemarrhena rhizome;
The preparation method of the fructus ulmi concentrated solution comprises the following steps:
Step a, baking fructus ulmi at 55 ℃, and crushing to obtain 80 mu m fructus ulmi powder;
And b, reflux-extracting the fructus ulmi powder with 250mL of 90% ethanol for 5 times, combining the extracting solutions, and removing the solvent to obtain the fructus ulmi concentrated solution.
The traditional Chinese medicine composition is suspension, and the specific preparation method is as follows:
parching the dry paint until the dry paint is completely smoked, uniformly mixing the dry paint with other components except the ulmus pumila concentrated solution according to a designed proportion, crushing and sieving to obtain a first mixture with the particle size of 250 mu m;
Adding 400mL of deionized water into the first mixture, soaking for 2 hours with low fire at 45 ℃, boiling, decocting for 0.5 hour with low fire at 80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
Adding 180mL of deionized water into the second mixture, decocting for 0.5h at 60 ℃ with slow fire, filtering, and removing filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting with low fire at 40 ℃ to obtain the traditional Chinese medicine composition.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating chicken histomonas, which comprises the following specific contents:
the traditional Chinese medicine composition comprises the following components in parts by weight: 7g of fructus ulmi concentrate, she Awei g of fine She Awei g, 6g of garden balsam stem root, 3g of pericarpium Granati, 0.8g of dry paint, 3g of carpesium, 2.5g of fried fructus quisqualis, 2g of radix scutellariae, 3g of herba pogostemonis, 3g of poria cocos, 1.5g of gypsum, 2g of radix ophiopogonis and 3g of rhizoma anemarrhenae;
The preparation method of the fructus ulmi concentrated solution comprises the following steps:
step a, baking fructus ulmi at 60 ℃, and crushing to obtain 80 mu m fructus ulmi powder;
And b, reflux-extracting the fructus ulmi powder with 220mL of 90% ethanol for 4 times, combining the extracting solutions, and removing the solvent to obtain the fructus ulmi concentrated solution.
The traditional Chinese medicine composition is suspension, and the specific preparation method is as follows:
Parching the dry paint until the dry paint is completely smoked, uniformly mixing the dry paint with other components except the ulmus pumila concentrated solution according to a designed proportion, crushing and sieving to obtain a first mixture with the particle size of 200 mu m;
Adding 430mL deionized water into the first mixture, soaking for 2 hours with low fire at 45 ℃, boiling, decocting for 0.5 hour with low fire at 80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
Adding 180mL of deionized water into the second mixture, decocting for 0.5h at 60 ℃ with slow fire, filtering, and removing filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting with low fire at 40 ℃ to obtain the traditional Chinese medicine composition.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating chicken histomonas, which comprises the following specific contents:
The traditional Chinese medicine composition comprises the following components in parts by weight: 4g of fructus ulmi concentrate, she Awei g of fine powder, 8g of garden balsam stem root, 3g of pericarpium Granati, 0.6g of dry paint, 3g of carpesium, 2.5g of fried fructus quisqualis, 3g of radix scutellariae, 3g of herba pogostemonis, 2g of poria cocos, 1g of gypsum, 3g of radix ophiopogonis and 2g of rhizoma anemarrhenae;
The preparation method of the fructus ulmi concentrated solution comprises the following steps:
Step a, baking fructus ulmi at 55 ℃, and crushing to obtain 80 mu m fructus ulmi powder;
And b, reflux-extracting the fructus ulmi powder with 100mL of 90% ethanol for 3 times, combining the extracting solutions, and removing the solvent to obtain the fructus ulmi concentrated solution.
The traditional Chinese medicine composition is suspension, and the specific preparation method is as follows:
Parching the dry paint until the dry paint is completely smoked, uniformly mixing the dry paint with other components except the ulmus pumila concentrated solution according to a designed proportion, crushing and sieving to obtain a first mixture with the particle size of 300 mu m;
Adding 350mL of deionized water into the first mixture, soaking for 2 hours with low fire at 45 ℃, boiling, decocting for 0.5 hour with low fire at 80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
Adding 180mL of deionized water into the second mixture, decocting for 0.5h at 60 ℃ with slow fire, filtering, and removing filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting with low fire at 40 ℃ to obtain the traditional Chinese medicine composition.
Comparative example 1
The comparative example provides a traditional Chinese medicine composition for treating chicken histomonas, the fructus ulmi extract in the example 1 is replaced by gamboge, and other components and preparation processes are unchanged, and the specific contents are as follows:
the traditional Chinese medicine composition comprises the following components in parts by weight: 6g of gamboge, she Awei g of fine She Awei g of garden balsam stem root, 3g of pomegranate rind, 0.6g of dry paint, 3g of carpesium fruit, 2.5g of fried fructus quisqualis, 2g of baical skullcap root, 3g of patchouli, 3g of Indian buead, 1g of gypsum, 2g of dwarf lilyturf tuber and 2g of common anemarrhena rhizome;
The traditional Chinese medicine composition is suspension, and the specific preparation method is as follows:
Parching the dry lacquer until the dry lacquer is completely smoked, uniformly mixing the dry lacquer with other components except gamboge according to a designed proportion, crushing and sieving to obtain a first mixture with the particle size of 300 mu m;
Adding 350mL of deionized water into the first mixture, soaking for 2 hours with low fire at 45 ℃, boiling, decocting for 0.5 hour with low fire at 80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
Adding 180mL of deionized water into the second mixture, decocting for 0.5h at 60 ℃ with slow fire, filtering, and removing filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting with low fire at 40 ℃ to obtain the traditional Chinese medicine composition.
Comparative example 2
The comparative example provides a traditional Chinese medicine composition for treating chicken histomonas, wherein the rhizoma cyrtomii is replaced by the rhizoma cyrtomii She Awei in the example 1, and other components and preparation processes are unchanged, and the specific contents are as follows:
the traditional Chinese medicine composition comprises the following components in parts by weight: 6g of fructus ulmi concentrate, 6g of cyrtomium rhizome, 5g of garden balsam stem root, 3g of pericarpium granati, 0.6g of dry paint, 3g of carpesium, 2.5g of fried fructus quisqualis, 2g of radix scutellariae, 3g of herba pogostemonis, 3g of poria cocos, 1g of gypsum, 2g of radix ophiopogonis and 2g of rhizoma anemarrhenae;
The preparation method of the fructus ulmi concentrated solution comprises the following steps:
Step a, baking fructus ulmi at 55 ℃, and crushing to obtain 80 mu m fructus ulmi powder;
and b, reflux-extracting the fructus ulmi powder with 200mL of 90% ethanol for 4 times, combining the extracting solutions, and removing the solvent to obtain the fructus ulmi concentrated solution.
The traditional Chinese medicine composition is suspension, and the specific preparation method is as follows:
Parching the dry paint until the dry paint is completely smoked, uniformly mixing the dry paint with other components except the ulmus pumila concentrated solution according to a designed proportion, crushing and sieving to obtain a first mixture with the particle size of 300 mu m;
Adding 350mL of deionized water into the first mixture, soaking for 2 hours with low fire at 45 ℃, boiling, decocting for 0.5 hour with low fire at 80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
Adding 180mL of deionized water into the second mixture, decocting for 0.5h at 60 ℃ with slow fire, filtering, and removing filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting with low fire at 40 ℃ to obtain the traditional Chinese medicine composition.
Comparative example 3
The comparative example provides a traditional Chinese medicine composition for treating chicken histomonas, wherein the garden balsam stem root in the example 1 is replaced by a crane bud, and other components and preparation processes are unchanged, and the specific contents are as follows:
The traditional Chinese medicine composition comprises the following components in parts by weight: 6g of fructus ulmi concentrate, she Awei g of hairyvein agrimony bud, 3g of pericarpium Granati, 0.6g of dry paint, 3g of carpesium, 2.5g of fried fructus quisqualis, 2g of radix scutellariae, 3g of herba pogostemonis, 3g of poria cocos, 1g of gypsum, 2g of radix ophiopogonis and 2g of rhizoma anemarrhenae;
The preparation method of the fructus ulmi concentrated solution comprises the following steps:
Step a, baking fructus ulmi at 55 ℃, and crushing to obtain 80 mu m fructus ulmi powder;
and b, reflux-extracting the fructus ulmi powder with 200mL of 90% ethanol for 4 times, combining the extracting solutions, and removing the solvent to obtain the fructus ulmi concentrated solution.
The traditional Chinese medicine composition is suspension, and the specific preparation method is as follows:
Parching the dry paint until the dry paint is completely smoked, uniformly mixing the dry paint with other components except the ulmus pumila concentrated solution according to a designed proportion, crushing and sieving to obtain a first mixture with the particle size of 300 mu m;
Adding 350mL of deionized water into the first mixture, soaking for 2 hours with low fire at 45 ℃, boiling, decocting for 0.5 hour with low fire at 80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
Adding 180mL of deionized water into the second mixture, decocting for 0.5h at 60 ℃ with slow fire, filtering, and removing filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting with low fire at 40 ℃ to obtain the traditional Chinese medicine composition.
Test examples
Test animals: a chicken farm in Xin Jishi of Hebei province is used for determining a sick chicken with histomonas according to clinical symptom observation and pathological section examination as a test chicken.
Test chicken clinical symptoms: in the early stage of disease, the chickens are sensitive and excited, raking or picking occurs, the feed intake is reduced, and chickens raised on the ground in a flat way can find chicken manure on the ground and eat the chicken manure;
in the middle period of onset, the sick chicken has poor spirit, greatly reduces appetite, sleeps with low activity;
In the later stage of the disease, the sick chicken cockscomb and the skin of the legs and feet are pale, watery diarrhea occurs, the feces are yellow and are in a coal tar shape, and the sick chicken dies.
Pathological section of test chicken: cecum bleeding, blood clot in intestinal contents, wall thickness and hypertrophy of cecum, hepatomegaly, circular or irregular subsidence dead zone on the surface, pale yellow or pale green color, edge bulge, more or less different ulcer ranges, erosion and ulcer at the joint of adenosis, stomach and muscle and stomach with different degrees, full crop and black brown sour and odorous liquid in the interior; the gallbladder color is changed from green to dark, and bile overflows.
Laboratory examination: fresh liver and intestine contents of the sick chickens are taken, diluted by 0.75 percent physiological saline, stained with slices and colored, and the accurate diagnosis of the bodies of insects can be seen.
Test method
The chickens in the early, middle and later stages are respectively divided into 6 groups, the traditional Chinese medicine composition obtained in the embodiment 1 of the application is a group, the traditional Chinese medicine composition obtained in the comparative examples 1-3 is three groups, the commercially available western medicines (dimetimidazole tablet, manufacturing enterprises: jinan Daming veterinary medicine raw materials limited company, which is administrated according to the requirements of the specification) are a group and a blank control group, the chickens are mixed with feed according to 0.02% of the weight of the chickens, the administration is continued for 3 days, and the result is shown in table 1, wherein the cure standard is: the spirit of the sick chicken returns to normal, the drinking water is normal, the pathological section is checked to have no pathological changes, and the laboratory is checked to have no worm.
Table 1 test results
According to table 1, it can be seen that the traditional Chinese medicine composition provided by the embodiment 1 of the application can rapidly and effectively treat chicken histomonas, has the advantages of small toxic and side effects, difficult generation of drug resistance, convenient use, only need to be uniformly mixed with feed, shortened disease healing time, avoidance of drug residue caused by long-time treatment, effective promotion of organism growth, enhancement of organism immunity, improvement of organism disease resistance and the like, and has remarkable effects in the aspect of treating chicken histomonas.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, or alternatives falling within the spirit and principles of the invention.
Claims (9)
1. A traditional Chinese medicine composition for treating chicken histomonas disease is characterized in that: the raw material medicine for preparing the traditional Chinese medicine composition comprises the following components in parts by weight: 1-10 parts of fructus ulmi concentrated solution, 1-10 parts of fine She Awei, 1-10 parts of garden balsam stem root, 1-6 parts of pericarpium Granati, 0.5-1 part of dry paint and 1-5 parts of carpesium;
The preparation method of the fructus ulmi concentrated solution comprises the following steps:
step a, baking fructus ulmi at 55-65 ℃ and crushing to obtain fructus ulmi powder;
Step b, reflux-extracting the fructus ulmi powder with ethanol solution for 3-5 times, mixing the extracting solutions, and concentrating to obtain fructus ulmi concentrated solution;
in the step b, the mass concentration of the ethanol solution is 85% -95%.
2. The traditional Chinese medicine composition for treating chicken histomonas according to claim 1, wherein the traditional Chinese medicine composition is characterized by: the raw material medicine for preparing the traditional Chinese medicine composition also comprises the following components in parts by weight: 1-5 parts of fried fructus quisqualis, 1-5 parts of radix scutellariae, 2-5 parts of herba pogostemonis, 1-5 parts of poria cocos, 0.5-2 parts of gypsum, 1-4 parts of radix ophiopogonis and 1-5 parts of rhizoma anemarrhenae.
3. The traditional Chinese medicine composition for treating chicken histomonas according to claim 2, wherein the traditional Chinese medicine composition is characterized by: the raw material medicine for preparing the traditional Chinese medicine composition comprises the following components in parts by weight: 3-8 parts of fructus ulmi concentrated solution, 3-7 parts of fine She Awei parts of garden balsam stem root, 3-9 parts of pomegranate rind, 2-4 parts of dried paint, 0.6-0.8 part of carpesium, 2-4 parts of stir-fried fructus quisqualis, 2-3 parts of radix scutellariae, 3-4 parts of herba pogostemonis, 2-3 parts of poria cocos, 1-1.5 parts of gypsum, 2-3 parts of radix ophiopogonis and 1.5-3 parts of rhizoma anemarrhenae.
4. The traditional Chinese medicine composition for treating chicken histomonas according to claim 1, wherein the traditional Chinese medicine composition is characterized by: in the step a, the particle size of the fructus ulmi powder is 80-100 mu m; and/or
In the step b, the mass ratio of the ulmus powder to the ethanol solution is 1:25-35; and/or
In the step b, the concentration temperature is 70-75 ℃ and the concentration time is 25-35 min.
5. A method for preparing a traditional Chinese medicine composition for treating chicken histomonas according to any one of claims 1-4, which is characterized in that: the method comprises the following steps:
parching the dry paint until the dry paint is completely smoked, weighing other components except the fructus ulmi concentrated solution according to the designed proportion, uniformly mixing, crushing and sieving to obtain a first mixture;
adding deionized water into the first mixture, soaking for 2-3 h with small fire, boiling, decocting for 0.5-1 h at 75-80 ℃, and filtering to obtain a second mixture and a first liquid medicine;
adding deionized water into the second mixture, decocting with slow fire, filtering, and discarding filter residues to obtain a second liquid medicine;
And fourthly, uniformly mixing the first liquid medicine, the second liquid medicine and the fructus ulmi concentrated solution, and decocting for 1h to 1.5h at the temperature of 40 ℃ to 45 ℃ to obtain the traditional Chinese medicine composition for treating chicken histomonas.
6. The method for preparing the traditional Chinese medicine composition for treating chicken histomonas according to claim 5, which is characterized in that: in the first step, the particle size of the first mixture is 200-300 mu m; and/or
In the second step, the mass ratio of the deionized water to the first mixture is 10-12:1-1.2; and/or
In the third step, the mass ratio of the deionized water to the second mixture is 5-6:1-1.5.
7. The method for preparing the traditional Chinese medicine composition for treating chicken histomonas according to claim 5, which is characterized in that: in the second step, the temperature of the small fire is 45-50 ℃; and/or
In the third step, the temperature of the slow fire is 60-70 ℃.
8. A traditional Chinese medicine preparation for treating chicken histomonas is characterized in that: the Chinese medicinal composition for treating chicken histomonas according to any one of claims 1-4 as an active ingredient.
9. The traditional Chinese medicine preparation according to claim 8, wherein: the traditional Chinese medicine preparation is in the form of a suspension.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101670012A (en) * | 2009-09-18 | 2010-03-17 | 天津诺康动物药业有限公司 | Traditional Chinese medicine composite for treating chicken histomoniasis and preparation method thereof |
| CN102727596A (en) * | 2012-07-18 | 2012-10-17 | 天津生机集团股份有限公司 | Chinese medicinal granula for preventing and controlling coccidiosis in chicken and preparation method thereof |
| CN107998257A (en) * | 2018-01-16 | 2018-05-08 | 任书梅 | A kind of Chinese medicine composition for treating enterohepatitis and preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670012A (en) * | 2009-09-18 | 2010-03-17 | 天津诺康动物药业有限公司 | Traditional Chinese medicine composite for treating chicken histomoniasis and preparation method thereof |
| CN102727596A (en) * | 2012-07-18 | 2012-10-17 | 天津生机集团股份有限公司 | Chinese medicinal granula for preventing and controlling coccidiosis in chicken and preparation method thereof |
| CN107998257A (en) * | 2018-01-16 | 2018-05-08 | 任书梅 | A kind of Chinese medicine composition for treating enterohepatitis and preparation method and application |
Non-Patent Citations (1)
| Title |
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| 养鸡驱虫防治措施;孙敏等;现代种业;20050430(第04期);30-31 * |
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