CN116440234A - 一种活血再造双柏散制剂改变为浸膏剂的制备方法 - Google Patents
一种活血再造双柏散制剂改变为浸膏剂的制备方法 Download PDFInfo
- Publication number
- CN116440234A CN116440234A CN202310459790.9A CN202310459790A CN116440234A CN 116440234 A CN116440234 A CN 116440234A CN 202310459790 A CN202310459790 A CN 202310459790A CN 116440234 A CN116440234 A CN 116440234A
- Authority
- CN
- China
- Prior art keywords
- powder
- extract
- mint
- filtrate
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 50
- 239000000284 extract Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000009023 shuang-bai Substances 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 19
- 239000004288 Sodium dehydroacetate Substances 0.000 claims abstract description 10
- 229940079839 sodium dehydroacetate Drugs 0.000 claims abstract description 10
- 235000019259 sodium dehydroacetate Nutrition 0.000 claims abstract description 10
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 claims abstract description 10
- 239000000341 volatile oil Substances 0.000 claims abstract description 10
- 238000004140 cleaning Methods 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000004806 packaging method and process Methods 0.000 claims abstract description 5
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 27
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 27
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 27
- 239000000706 filtrate Substances 0.000 claims description 24
- 241000972673 Phellodendron amurense Species 0.000 claims description 15
- 240000004980 Rheum officinale Species 0.000 claims description 14
- 235000008081 Rheum officinale Nutrition 0.000 claims description 14
- 240000002924 Platycladus orientalis Species 0.000 claims description 12
- 240000009138 Curcuma zedoaria Species 0.000 claims description 9
- 241000123589 Dipsacus Species 0.000 claims description 8
- 241001116742 Drynaria Species 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 244000246386 Mentha pulegium Species 0.000 claims description 7
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 7
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 7
- 235000001050 hortel pimenta Nutrition 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 238000001256 steam distillation Methods 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 239000008280 blood Substances 0.000 abstract description 12
- 210000004369 blood Anatomy 0.000 abstract description 12
- 208000002193 Pain Diseases 0.000 abstract description 9
- 230000036407 pain Effects 0.000 abstract description 9
- 230000008961 swelling Effects 0.000 abstract description 8
- 210000000988 bone and bone Anatomy 0.000 abstract description 7
- 230000001737 promoting effect Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 210000003734 kidney Anatomy 0.000 abstract description 4
- 238000010298 pulverizing process Methods 0.000 abstract description 4
- 238000005728 strengthening Methods 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 abstract description 2
- 230000003179 granulation Effects 0.000 abstract description 2
- 230000001338 necrotic effect Effects 0.000 abstract description 2
- 238000012827 research and development Methods 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 238000007605 air drying Methods 0.000 abstract 1
- 238000000643 oven drying Methods 0.000 abstract 1
- 239000006187 pill Substances 0.000 description 8
- 206010042674 Swelling Diseases 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 230000008736 traumatic injury Effects 0.000 description 4
- 201000000736 Amenorrhea Diseases 0.000 description 3
- 206010001928 Amenorrhoea Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 231100000540 amenorrhea Toxicity 0.000 description 3
- 206010000060 Abdominal distension Diseases 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 235000003405 Curcuma zedoaria Nutrition 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 2
- 208000034507 Haematemesis Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 241000902900 cellular organisms Species 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- 239000000052 vinegar Substances 0.000 description 2
- 235000019509 white turmeric Nutrition 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000407170 Curcuma Species 0.000 description 1
- 235000014375 Curcuma Nutrition 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 241000735527 Eupatorium Species 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明所属中药研究开发技术领域。本发明涉及一种活血再造双柏散制剂改变为浸膏剂的制备方法。将大黄、侧柏叶、黄柏、莪术、薄荷、续断、骨碎补、泽兰分别洗净、烘干或晾干,粉碎成粉末;将薄荷进行水蒸气蒸馏,获得薄荷挥发油;其它药材进行水提取,将提取液浓缩成浸膏剂,加入脱氢乙酸钠和薄荷挥发油到浸膏剂内,混匀,装瓶、包装。本发明产品浸膏剂有利于有效成分的释放,提高并达到治疗效果,具有补肾壮骨,活血化瘀,疏通经络,消肿止痛,去腐生肌之功能。
Description
技术领域
本发明所属中药研究开发技术领域。本发明涉及一种活血再造双柏散制剂改变为浸膏剂的制备方法。本发明产品浸膏剂有利于有效成分的释放,提高并达到治疗效果,具有补肾壮骨,活血化瘀,疏通经络,消肿止痛,去腐生肌之功能。
背景技术
活血再造双柏散是外用的处方类中成药,原辅料组成为大黄、侧柏叶、黄柏、莪术、薄荷、续断、骨碎补、泽兰、脱氢乙酸钠。
1.大黄
功能主治:泻热毒,破积滞,行瘀血。治实热便秘,谵语发托,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,痈疡肿毒。
用法用量:煎汤(用于泻下,不宜久煎),1~4钱;或入丸、散;外用适量,研末,水或醋调敷。
2.侧柏叶
功能主治:凉血止血,化痰止咳,生发乌发。用于吐血,衄血,咯血,便血,崩漏下血,肺热咳嗽,血热脱发,须发早白。
用法用量:煎服,6~12g。化痰止咳宜生用;止血多炒炭用;外用适量。
3.黄柏
功能主治:清热,燥湿,泻火,解毒。治热痢,泄泻,消渴,黄疸,梦遗,淋浊,痔疮,便血,亦白带下,骨蒸劳热,目赤肿痛,口舌生疮,疮疡肿毒。
用法用量:煎汤,1.5~3钱;或入丸、散;外用适量,研末调敷或煎水浸渍。
4.莪术
功能主治:行气破血、消积止痛。主治气血凝滞,心腹胀痛,症瘕,积聚,宿食不消,妇女血瘀经闭,跌打损伤作痛。
用法用量:水煎服,用量3-15g,也可以入丸或者散服用;可以醋制后对祛瘀止痛有效果;莪术也可以外用,外用也要适量,根据情况适量使用莪术。
5.薄荷
功能主治:疏风,散热,辟秽,解毒。治外感风热,头痛,目赤,咽喉肿痛,食滞气胀,口疮,牙痛,疮疥,瘾疹。发毒汗,破血止痢,通利关节。
用法用量:煎汤(不宜久煎),0.8~2钱;或入丸、散;外用适量,捣汁或煎汁涂敷。
6.续断
功能主治:补肝肾,续筋骨,调血脉。治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。
用法用量:粉碎为粉末,酒糊为丸,如梧桐子大。用法:每服30丸,空心以温酒下或盐汤送下。
7.骨碎补
功能主治:活血散瘀、消肿止痛、续筋接骨、补肾强骨。主治跌打损伤或创伤,筋骨损伤,瘀滞肿痛。
用法用量:煎服,10-20g;或入丸、散;外用适量,捣敷或研末调敷;或浸酒搽。
8.泽兰
功能主治:活血,行水。治经闭,癥瘕,产后瘀滞腹痛,身面浮肿,跌扑损伤,金疮,痈肿。
用法用量:煎汤,1.5~3钱;或入丸、散;外用适量,捣敷或煎水熏洗。
传统活血再造双柏散的制备方法:将大黄、侧柏叶、黄柏、莪术、薄荷、续断、骨碎补、泽兰粉碎为粉末。
方剂用法:开水、蜜调敷粉末至患处。
鉴于上述方法制备的活血再造双柏散制剂不利于有效成分释放,导致治疗效果不佳,且浪费药材。我们将活血再造双柏散制剂改变为浸膏剂,浸膏剂有利于有效成分的释放,提高疗效,达到治疗效果并能节省药材。
发明内容
1、一种活血再造双柏散制剂改变为浸膏剂的制备方法,其特征在于步骤如下:
(1)原辅料组成为大黄、侧柏叶、黄柏、莪术、薄荷、续断、骨碎补、泽兰、脱氢乙酸钠;
(2)将(1)中的莪术、续断、骨碎补、泽兰分别洗净、烘干,粉碎成20-40目粉末;
(3)将(1)中的大黄、侧柏叶、黄柏分别洗净、烘干,粉碎成20-40目粉末;
(4)将(1)中的薄荷洗净、晾干,粉碎成10-20目粉末;
(5)将(4)中的薄荷20-40目粉末放入蒸馏器中进行水蒸气蒸馏,获得薄荷挥发油和薄荷残渣;
(6)将(2)中的莪术、续断、骨碎补、泽兰20-40目粉末放入不锈钢容器内,加水煎煮1h-1.5h,再放入(3)中的大黄、侧柏叶、黄柏20-40目粉末和(5)中的薄荷残渣,继续煎煮0.5h-1.0h;加水量为药材总重量的5-6倍,温度为100℃,得滤液和残渣;
(7)将(6)中的残渣再加水煎煮1h-1.5h,加水量为药材总重量的4-5倍,温度为80-95℃,过滤,得滤液和残渣;
(8)将(7)中的残渣压滤,滤液与(6)和(7)中滤液合并;
(9)将(8)中的滤液减压浓缩成浸膏剂;
(10)将(1)中的脱氢乙酸钠和(5)中的薄荷挥发油加入到(9)中浸膏剂内,混匀,装瓶、包装。
具体实施方式
本发明所述的涉及一种活血再造双柏散制剂改变为浸膏剂的制备方法,包括以下实施例,下面的实施例可进一步说明本发明,但不以任何方式限制本发明。
实施例1:
1、一种活血再造双柏散制剂改变为浸膏剂的制备方法,其特征在于步骤如下:
(1)原辅料组成为大黄、侧柏叶、黄柏、莪术、薄荷、续断、骨碎补、泽兰、脱氢乙酸钠;
(2)将(1)中的莪术、续断、骨碎补、泽兰分别洗净、烘干,粉碎成20目粉末;
(3)将(1)中的大黄、侧柏叶、黄柏分别洗净、烘干,粉碎成20目粉末;
(4)将(1)中的薄荷洗净、晾干,粉碎成10目粉末;
(5)将(4)中的薄荷20目粉末放入蒸馏器中进行水蒸气蒸馏,获得薄荷挥发油和薄荷残渣;
(6)将(2)中的莪术、续断、骨碎补、泽兰20目粉末放入不锈钢容器内,加水煎煮1h,再放入(3)中的大黄、侧柏叶、黄柏20目粉末和(5)中的薄荷残渣,继续煎煮0.5h;加水量为药材总重量的5倍,温度为100℃,得滤液和残渣;
(7)将(6)中的残渣再加水煎煮1h,加水量为药材总重量的4倍,温度为80℃,过滤,得滤液和残渣;
(8)将(7)中的残渣压滤,滤液与(6)和(7)中滤液合并;
(9)将(8)中的滤液减压浓缩成浸膏剂;
(10)将(1)中的脱氢乙酸钠和(5)中的薄荷挥发油加入到(9)中浸膏剂内,混匀,装瓶、包装。
实施例2:
1、一种活血再造双柏散制剂改变为浸膏剂的制备方法,其特征在于步骤如下:
(1)原辅料组成为大黄、侧柏叶、黄柏、莪术、薄荷、续断、骨碎补、泽兰、脱氢乙酸钠;
(2)将(1)中的莪术、续断、骨碎补、泽兰分别洗净、烘干,粉碎成40目粉末;
(3)将(1)中的大黄、侧柏叶、黄柏分别洗净、烘干,粉碎成40目粉末;
(4)将(1)中的薄荷洗净、晾干,粉碎成20目粉末;
(5)将(4)中的薄荷40目粉末放入蒸馏器中进行水蒸气蒸馏,获得薄荷挥发油和薄荷残渣;
(6)将(2)中的莪术、续断、骨碎补、泽兰40目粉末放入不锈钢容器内,加水煎煮1.5h,再放入(3)中的大黄、侧柏叶、黄柏40目粉末和(5)中的薄荷残渣,继续煎煮1.0h;加水量为药材总重量的6倍,温度为100℃,得滤液和残渣;
(7)将(6)中的残渣再加水煎煮1.5h,加水量为药材总重量的5倍,温度为95℃,过滤,得滤液和残渣;
(8)将(7)中的残渣压滤,滤液与(6)和(7)中滤液合并;
(9)将(8)中的滤液减压浓缩成浸膏剂;
(10)将(1)中的脱氢乙酸钠和(5)中的薄荷挥发油加入到(9)中浸膏剂内,混匀,装瓶、包装。
Claims (1)
1.一种活血再造双柏散制剂改变为浸膏剂的制备方法,其特征在于步骤如下:
(1)原辅料组成为大黄、侧柏叶、黄柏、莪术、薄荷、续断、骨碎补、泽兰、脱氢乙酸钠;
(2)将(1)中的莪术、续断、骨碎补、泽兰分别洗净、烘干,粉碎成20-40目粉末;
(3)将(1)中的大黄、侧柏叶、黄柏分别洗净、烘干,粉碎成20-40目粉末;
(4)将(1)中的薄荷洗净、晾干,粉碎成10-20目粉末;
(5)将(4)中的薄荷20-40目粉末放入蒸馏器中进行水蒸气蒸馏,获得薄荷挥发油和薄荷残渣;
(6)将(2)中的莪术、续断、骨碎补、泽兰20-40目粉末放入不锈钢容器内,加水煎煮1h-1.5h,再放入(3)中的大黄、侧柏叶、黄柏20-40目粉末和(5)中的薄荷残渣,继续煎煮0.5h-1.0h;加水量为药材总重量的5-6倍,温度为100℃,得滤液和残渣;
(7)将(6)中的残渣再加水煎煮1h-1.5h,加水量为药材总重量的4-5倍,温度为80-95℃,过滤,得滤液和残渣;
(8)将(7)中的残渣压滤,滤液与(6)和(7)中滤液合并;
(9)将(8)中的滤液减压浓缩成浸膏剂;
(10)将(1)中的脱氢乙酸钠和(5)中的薄荷挥发油加入到(9)中浸膏剂内,混匀,装瓶、包装。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310459790.9A CN116440234A (zh) | 2023-04-23 | 2023-04-23 | 一种活血再造双柏散制剂改变为浸膏剂的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310459790.9A CN116440234A (zh) | 2023-04-23 | 2023-04-23 | 一种活血再造双柏散制剂改变为浸膏剂的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN116440234A true CN116440234A (zh) | 2023-07-18 |
Family
ID=87125467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202310459790.9A Pending CN116440234A (zh) | 2023-04-23 | 2023-04-23 | 一种活血再造双柏散制剂改变为浸膏剂的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN116440234A (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105596504A (zh) * | 2014-11-20 | 2016-05-25 | 王浩 | 一种外敷双柏散及其制备方法 |
-
2023
- 2023-04-23 CN CN202310459790.9A patent/CN116440234A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105596504A (zh) * | 2014-11-20 | 2016-05-25 | 王浩 | 一种外敷双柏散及其制备方法 |
Non-Patent Citations (3)
Title |
---|
史坚鸣: "136例骨折后遗症的中西医疗效比较", 上海中医药杂志, no. 10, 15 October 2000 (2000-10-15), pages 30 * |
周添浓,陈佃,叶会呈: "双柏软膏的研制", 中成药, no. 10, 20 October 1994 (1994-10-20), pages 10 * |
尹宏兵;崔镇海;刘达;李志清;龚庆;金美英;: "克雷氏骨折手法整复术后康复治疗进展", 中国医药指南, no. 11, 20 April 2013 (2013-04-20), pages 42 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104857157A (zh) | 一种治疗子宫内膜增殖症的汤剂药物及制备方法 | |
CN106620539A (zh) | 治疗皮肤病的外用药膏、制备方法及其应用 | |
CN101884716A (zh) | 一种治疗腰间盘突出的药酒 | |
CN102552608B (zh) | 一种治疗骨折、骨损伤的药物组合物及其制备方法和用途 | |
CN103933405A (zh) | 用于治疗气血两虚型烧伤的药物组合物及其制备方法 | |
CN101085302B (zh) | 一种外敷治疗乳腺增生的膏剂 | |
CN105456923B (zh) | 一种祛瘀止痛的中药组合物及其制备方法 | |
CN116440234A (zh) | 一种活血再造双柏散制剂改变为浸膏剂的制备方法 | |
CN113813324A (zh) | 一种治疗骨质疏松、股骨头坏死的中药组合物及其制备方法 | |
CN101518579B (zh) | 一种稳压疏通药及制备工艺 | |
CN111603528A (zh) | 一种用于治疗痛症和调理经络的外用药物及其制备方法 | |
CN104173775A (zh) | 颈源性头痛中药组合物及制备方法 | |
CN115645484B (zh) | 一种治疗骨伤疾病的中药组合物及其制备方法、制剂与应用 | |
CN114732879B (zh) | 一种用于痛风和尿酸高的药物组合物及其制备方法与用途 | |
CN110013513B (zh) | 一种治疗风湿骨痛的外用凝胶及其制备方法 | |
CN106039045A (zh) | 一种用于治疗颈椎病的中药组合物及其制剂的制备方法 | |
CN104474452A (zh) | 一种治疗血凝蕴毒型褥疮的药物及其制备方法 | |
CN114099628A (zh) | 一种降高血压的中药组合物及制备方法 | |
CN105363000A (zh) | 丹参附子药酒 | |
CN114452361A (zh) | 一种治疗颈肩腰腿痛的外敷膏药及其制备方法 | |
CN1628789A (zh) | 治疗毛发脱落的斑蝥毛姜酊和复方生发胶囊 | |
CN118267443A (zh) | 一种祛风健骨外敷膏及其制备方法 | |
CN113813322A (zh) | 一种祛寒湿的药酒及其制备方法 | |
CN110538282A (zh) | 一种暖宫调经的艾药灸条及其制备方法 | |
CN113577166A (zh) | 一种药油及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |