CN116196234A - 一种具有焕颜提亮美白功效的护肤组合物及应用 - Google Patents
一种具有焕颜提亮美白功效的护肤组合物及应用 Download PDFInfo
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Abstract
本发明公开了具体涉及一种具有焕颜提亮美白功效的护肤组合物及应用，包括麦角硫因、依克多因、泛醇、对羟基苯乙酮等功能成分。本发明美白途径有以下几点：一是通过抑制酪氨酸酶从而抑制黑色素产品；二是促进已生成的黑色素排出体外；三是通过补水保湿，角质层吸水，从而使皮肤透亮、有光泽。首次发现麦角硫因、依克多因(四氢甲基嘧啶羧酸)、泛醇、对羟基苯乙酮几种功能成分具有可协同增效抑制酪氨酸酶活性的作用。
Description
技术领域
本发明属于护肤品领域，具体涉及一种具有焕颜提亮美白功效的护肤组合物及应用。
背景技术
亚洲女性普遍偏黄的肌质，而传统美的观念里即有“一白遮百丑”的说法，因此市面上美白化妆品长盛不衰，美白精华已经成为众多年轻女性必备的保养品。随着科学技术和生活水平的提高，人们对美白类化妆品的需求已从单纯的物理性遮盖向功能性转化。
市面上美白类护肤品产品质量良莠不齐，许多美白类化妆品以追求高效美白为主要目的，而逐渐忽视了产品在使用过程中对人体皮肤的伤害风险。如市面上比较多的美白产品都是以维生素C、烟酰胺为主要成分。维生素C不稳定性，难以根除黑色素的生成。而烟酰胺在高浓度时才具有显著的抑制酪氨酸酶活性，但是在使用高浓度烟酰胺产品时，很多人会出现皮肤会不耐受的情况，出现红、肿、痒、刺痛等过敏反应。
发明内容
发明目的：本发明所要解决的技术问题是针对现有技术的不足，提供一种安全性高、功效明显的护肤组合物，实现焕颜提亮美白护肤的功效，以满足现代人们的需求。
为了实现上述目的，本发明采取的技术方案如下：
一种具有焕颜提亮美白功效的护肤组合物，包括如下功能成分：麦角硫因、依克多因、泛醇、对羟基苯乙酮。
本发明美白途径有以下几点：一是通过抑制酪氨酸酶从而抑制黑色素产品；二是促进已生成的黑色素排出体外；三是通过补水保湿，角质层吸水，从而使皮肤透亮、有光泽。
其中，麦角硫因是一种天然的抗氧化剂，安全无毒，特殊的理化性质及特定分布使其稳定性明显优于一般常用的抗氧化剂。本发明研究发现，微量的麦角硫因即能有效降低酪氨酸酶的活性。
依克多因(四氢甲基嘧啶羧酸)可作为外用护肤品发挥去除黑色素，以及抗黑色素生成的效果。
泛醇通过增强能量代谢，可以让细胞产生更多的能量，加快细胞代谢从而使黑色素更快被代谢排出。
对羟基苯乙酮既具有抑制酪氨酸酶活性，同时具有舒缓、抗敏、防腐等功效。
进一步地，皮肤缺水和失去光泽，也会导致肤色的暗沉。为此，本发明具有焕颜提亮美白护肤功效的护肤组合物还包括补水保湿化妆品原料。
具体地，所述的补水保湿化妆品原料包括透明质酸或其盐、尿囊素、甘油葡糖苷、甘油、1,2-己二醇，丁二醇，β-葡聚糖中的一种或两种以上的组合。
具体地，所述的透明质酸或其盐选自透明质酸、水解透明质酸、透明质酸钠、水解透明质酸钠、透明质酸钠交联聚合物、乙酰化透明质酸钠中的至少一种。
优选地，本发明具有焕颜提亮美白护肤功效的护肤组合物，具体包括如下质量百分比的组分：
麦角硫因0.01-5wt％、依克多因0.01-10wt％、泛醇0.01-5wt％、对羟基苯乙酮0.05-1wt％、透明质酸或其盐0.01-5wt％、尿囊素0.01-0.5wt％、甘油葡糖苷0.01-5wt％、甘油0.1-15wt％、1,2-己二醇0.1-5wt％，余量为水。
进一步地，本发明护肤组合物能够单独或者与其他辅料一起制成膏霜、乳液、精华液、保湿水或面膜液等产品。
更进一步地，本发明还要求保护上述护肤组合物在用于美白护肤中的应用。
更进一步地，本发明还要求保护上述护肤组合物在用于皮肤保湿抗皱中的应用。
更进一步地，本发明还要求保护上述护肤组合物在用于皮肤抗衰老中的应用。
更进一步地，本发明还要求保护上述护肤组合物在用于提亮肤色中的应用。
有益效果：
(1)本发明提供了一种具有焕颜提亮美白功效的护肤组合物包括麦角硫因、依克多因(四氢甲基嘧啶羧酸)、泛醇、对羟基苯乙酮、补水保湿化妆品原料，通过多通路解决美白问题。
(2)本发明首次发现，麦角硫因、依克多因(四氢甲基嘧啶羧酸)、泛醇、对羟基苯乙酮几种功能成分具有可协同增效抑制酪氨酸酶活性的作用。
(3)本发明提供的护肤组合物，选用的原料均安全、无刺激，且具有明显的美白功效。
具体实施方式
根据下述实施例，可以更好地理解本发明。
实施例1：一种护肤组合物，基于所述护肤组合物的总重量，所述护肤组合物包含：麦角硫因0.1wt％、依克多因(四氢甲基嘧啶羧酸)0.5wt％、泛醇1wt％、对羟基苯乙酮1wt％、透明质酸或其盐1wt％、尿囊素0.1wt％、甘油葡糖苷0.2wt％、甘油2wt％、1,2-己二醇1wt％，余量为水。
实施例2：一种护肤组合物，基于所述护肤组合物的总重量，所述护肤组合物包含：麦角硫因0.05wt％、依克多因(四氢甲基嘧啶羧酸)2wt％、泛醇1wt％、对羟基苯乙酮0.5wt％、透明质酸或其盐1wt％、尿囊素0.1wt％、甘油葡糖苷0.2wt％、甘油2wt％、1,2-己二醇1wt％，余量为水。
实施例3：一种护肤组合物，基于所述护肤组合物的总重量，所述护肤组合物包含：麦角硫因0.1wt％、依克多因(四氢甲基嘧啶羧酸)1wt％、泛醇0.5wt％、对羟基苯乙酮0.25wt％、透明质酸或其盐1wt％、尿囊素0.1wt％、甘油葡糖苷0.2wt％、甘油2wt％、1,2-己二醇1wt％，余量为水。
实施例与对照例配方如表1所示。
表1
性能与功效测试
(1)美白功效评价
在皮肤黑色素生物合成中，酪氨酸酶是关键酶，作用于多巴，形成多巴醌，后者自发进行一系列反应最后形成黑色素。因此，抑制酪氨酸酶活性可反映测试样品的美白功效。
测试方法：按照T/SHRH 015《化妆品-酪氨酸酶活性抑制实验方法》检测实施例1-3和对比例1-9所制备测试样品的抑制酪氨酸酶活性，结果如表2所示。
表2
| 测试样品 | 酪氨酸酶抑制率(％) |
| 实施例1 | 99 |
| 实施例2 | 98 |
| 实施例3 | 100 |
| 对照例1 | 36 |
| 对照例2 | 69 |
| 对照例3 | 72 |
| 对照例4 | 48 |
| 对照例5 | 70 |
| 对照例6 | 16 |
| 对照例7 | 13 |
| 对照例8 | 68 |
| 对照例9 | 53 |
通过表2测试结果可知：
1、实施例1-3所制备的化妆品组合物的酪氨酸酶活性抑制率高达96％-100％，均优于对照例。
1、与对照组1-7的数据比较发现，麦角硫因、依克多因和对羟基苯乙酮对于抑制酪氨酸酶活性具有协同增效效果。
3、实施例1-3所制备的化妆品组合物美白效果优于3％VC乙基醚和3％烟酰胺。本发明的实施例所用原料稳定性高，安全无刺激，且美白效果佳，安全性和功效均优于市面常用的美白原料。
(2)人体测试-美白效果验证
测试产品：本发明实施例1-3及对照例1-9得到的护肤组合物。
受试者：皮肤发黄、暗哑无光泽的人群，分成对应的观测小组，每个小组10人。
测试方法：各测试小组受试者分别取对应护肤组合物溶液，每天喷右手1-2次，左手不喷做对照试验。持续使用1个月，使用过程中感受产品是否有刺激性，1个月后肉眼观测受试者左右手皮肤状况的对照效果并进行评分，取评分的平均值。
美白效果评分评价指标说明：0分为无美白效果，1分为轻微变白，2分变白效果较明显，3分为变白效果明显，4分为变白效果非常明显。
测试结果见表3。
表3
通过上述的试验结果可以看出，本发明所述的护肤组合物，可以有效改善暗黄皮肤，达到较好的焕颜提亮美白效果，效果优于对照组，且安全无刺激。
(3)人体试验-保湿、敏感肌适用功效评价
通过招募33例面部皮肤泛红、眼角皱纹等级大于1级(D0)、Tew1≥10g/h/m2、皮肤角质层水分含量＜60(Corneometer Unit,C.U.)且乳酸刺痛感为阳性的敏感肌中国35～45岁身体健康的男性或女性受试者，连续使用测试样品(实施例3)28天，采用仪器测试及自我评估问卷的方法来观察样品使用14天和28天前后的变化，从而对连续使用测试样品14天和28天保湿、敏感肌适用功效进行综合评价。结果见表4和表5。
表4：保湿指标测试结果
表5受试者使用测试样品28天后的自我评估结果及统计分析结果
| 评价指标 | 使用样品28天后满意度评价 |
| 感觉产品有保湿效果 | 100％ |
| 感觉产品适用于敏感肌 | 100％ |
| 感觉产品使用感温和 | 100％ |
| 感觉产品整体使用感好 | 100％ |
*评价指标：1分为“非常不满意”，2分为“不满意”，3分为“一般”，4分为“满意”，5分为“非常满意”，统计N≥4分的人数占比。
*统计人数＝33。
以上结果可知，连续使用实施例3的测试样品14天及28天，测试样品具有保湿、敏感肌适用功效。
本发明提供了具体涉及一种具有焕颜提亮美白功效的护肤组合物及应用的思路及方法，具体实现该技术方案的方法和途径很多，以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。本实施例中未明确的各组成部分均可用现有技术加以实现。
Claims (10)
1.一种具有焕颜提亮美白功效的护肤组合物，其特征在于，包括如下功能成分：麦角硫因、依克多因、泛醇、对羟基苯乙酮。
2.根据权利要求1所述的具有焕颜提亮美白功效的护肤组合物，其特征在于，还包括补水保湿化妆品原料。
3.根据权利要求2所述的具有焕颜提亮美白功效的护肤组合物，其特征在于，所述的补水保湿化妆品原料包括透明质酸或其盐、尿囊素、甘油葡糖苷、甘油、1,2-己二醇，丁二醇，β-葡聚糖中的一种或两种以上的组合。
4.根据权利要求3所述的具有焕颜提亮美白功效的护肤组合物，其特征在于，所述的透明质酸或其盐选自透明质酸、水解透明质酸、透明质酸钠、水解透明质酸钠、透明质酸钠交联聚合物、乙酰化透明质酸钠中的至少一种。
5.根据权利要求1所述的具有焕颜提亮美白功效的护肤组合物，其特征在于，包括如下质量百分比的组分：
麦角硫因0.01-5wt％、依克多因0.01-10wt％、泛醇0.01-5wt％、对羟基苯乙酮0.05-1wt％、透明质酸或其盐0.01-5wt％、尿囊素0.01-0.5wt％、甘油葡糖苷0.01-5wt％、甘油0.1-15wt％、1,2-己二醇0.1-5wt％，余量为水。
6.根据权利要求1所述的具有焕颜提亮美白功效的护肤组合物，其特征在于，所述的护肤组合物能够制成膏霜、乳液、精华液、保湿水或面膜液。
7.权利要求1～5中任意一项所述的护肤组合物在用于美白护肤中的应用。
8.权利要求1～5中任意一项所述的护肤组合物在用于皮肤保湿抗皱中的应用。
9.权利要求1～5中任意一项所述的护肤组合物在用于皮肤抗衰老中的应用。
10.权利要求1～5中任意一项所述的护肤组合物在用于提亮肤色中的应用。
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