CN116171477A - 监测和滴定处理高海拔诱发的中枢性睡眠呼吸暂停(csa)的***和方法 - Google Patents
监测和滴定处理高海拔诱发的中枢性睡眠呼吸暂停(csa)的***和方法 Download PDFInfo
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- CN116171477A CN116171477A CN202180060076.1A CN202180060076A CN116171477A CN 116171477 A CN116171477 A CN 116171477A CN 202180060076 A CN202180060076 A CN 202180060076A CN 116171477 A CN116171477 A CN 116171477A
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Abstract
一种用于采用来自人和来自人所处的环境的数据的装置和方法便于检测和预测高海拔诱发的睡眠呼吸紊乱(SDB,并且特别是中枢性睡眠呼吸暂停(CSA))的严重性。SDB症状的严重性(客观或主观或两者)和局部大气压力的纵向跟踪允许预测(按照海拔的)SDB的发生。所有数据中的一些数据可以从可以由人穿戴的一个或多个可穿戴设备获得。另外,提供了用于处理高海拔诱发的SDB的药物(例如乙酰唑胺、低流量氧疗)的剂量的个性化映射,其中按照海拔向人提供推荐的剂量。
Description
相关申请的交叉引用
本申请要求于2020年7月20日提交的美国临时申请号63/054197的权益。该申请由此通过引用并入本文。
技术领域
本发明涉及中枢性睡眠呼吸暂停(CSA),并且具体地涉及用于监测和滴定处理高海拔诱发的CSA的装置和方法。
背景技术
高海拔诱发的中枢性睡眠呼吸暂停是常见的紊乱,多达25%的人群在7500英尺的高度处呈现出症状,并且约85%的人群在高于12000英尺的高度处呈现出症状。在高海拔处,呼吸性碱中毒是常见的,并且可能导致通气不稳定,具体是由于PaCO2与呼吸暂停阈值之间的差的降低,但也可能是由于回路增益的低碳酸血症增加。在睡眠期间,这种通气不稳定表现为呼吸的周期性暂停的持续时间超过十秒,这典型地与血氧饱和度降低、睡眠片断化和如头痛、疲劳、维持睡眠困难(睡眠维持性失眠)等的其它后遗症相关联。呼吸的暂停最典型地是由于呼吸努力的停止(中枢性呼吸暂停),但是由于回路增益的变化,阻塞性睡眠呼吸暂停也可能在海拔处显著恶化。
通常,高海拔诱发的中枢性睡眠呼吸暂停经常预防性地通过乙酰唑胺(Diamox)来处理,和/或通过夜间补充的低流量氧气来处理。两种处理都具有有问题的副作用,包括对于乙酰唑胺的感觉异常、头痛、恶心、尿频和味觉改变。低流量氧气使用具有皮肤刺激和鼻干燥的副作用。由于使用和运输低流量氧疗(即鼻插管和氧气浓缩器或压缩氧气瓶)的不便,低流量氧疗在许多情况下可能不优选用于处理。
因此,将期望改善监测和处理高海拔诱发的中枢性睡眠呼吸暂停的方式。
发明内容
因而,本发明的一个目的是提供一种改进的用于监测高海拔诱发的中枢性睡眠呼吸暂停和提供对高海拔诱发的中枢性睡眠呼吸暂停的滴定处理的装置和方法,其克服了传统的用于提供对遭受高海拔诱发的中枢性睡眠呼吸暂停的人的监测和处理的***和方法的缺点。根据本发明的一个实施例,通过提供一种装置和方法来实现该目的,其中来自人和来自人所处的环境的数据便于检测和预测高海拔诱发的睡眠呼吸紊乱(SDB,并且特别是中枢性睡眠呼吸暂停)的严重性。SDB症状的严重性(客观或主观或两者)和局部大气压力的纵向跟踪允许预测(按照海拔的)SDB的发生。所有数据中的一些数据可以从可以由人穿戴的一个或多个可穿戴设备获得。另外,提供了用于处理高海拔诱发的SDB的药物(例如乙酰唑胺、低流量氧疗)的剂量的个性化映射,其中按照海拔向人提供推荐的剂量。
高海拔诱发的中枢性睡眠呼吸暂停目前不能在现场诊断,也不具有动态地滴定处理。然而,根据所公开和要求保护的构思,包括大气压力传感器、光电体积描记器、加速度计和陀螺仪的可穿戴设备纵向地监测人的有效海拔和睡眠呼吸紊乱的严重性。如果在较高海拔但不是较低海拔处注意到睡眠呼吸紊乱(或在较高海拔处严重性显著增加),则该人被诊断为患有高海拔诱发的睡眠呼吸紊乱。
如果人已经被诊断为患有高海拔诱发的睡眠呼吸紊乱,则***跟踪海拔、SDB严重性和处理剂量,以便确定针对给定海拔的最佳处理剂量策略并基于海拔来预测后续夜晚的适当剂量。
因而,所公开和要求保护的构思的方面是通过一种改进的对人的海拔诱发的中枢性睡眠呼吸暂停(CSA)进行建模的方法来提供的,该方法的一般性质可以被表述为包括:确定针对该人的一定数目的睡眠时段中的每个睡眠时段的一定数目的SDB严重性值和一定数目的有效海拔值,该一定数目的SDB严重性值中的每个SDB严重性值与该一定数目的有效海拔值中的有效海拔值相对应;至少部分地基于该一定数目的睡眠呼吸紊乱(SDB)严重性值的至少子集和该一定数目的有效海拔值的至少子集,确定该人有可能遭受预定水平的SDB严重性的有效海拔;以及生成至少部分地基于该有效海拔的输出。
所公开和要求保护的构思的其他方面是通过一种改进的确定用于人的海拔诱发的中枢性睡眠呼吸暂停(CSA)处理的剂量的方法来提供的,该方法的一般性质可以被表述为包括:针对该人的一定数目的睡眠时段中的每个睡眠时段,确定一定数目的睡眠呼吸紊乱(SDB)严重性值,该一定数目的SDB严重性值中的每个SDB严重性值至少部分地基于对应有效海拔值和CSA处理的对应剂量;针对给定的有效海拔,至少部分地基于该一定数目的睡眠呼吸紊乱(SDB)严重性值的至少子集来确定CSA处理的优选剂量,在该优选剂量处可能的SDB严重性值不大于预定的SDB严重性值;以及生成至少部分地基于该剂量的输出。
所公开和要求保护的构思的其他方面是通过一种改进的被构造为确定用于人的海拔诱发的中枢性睡眠呼吸暂停(CSA)处理的剂量的装置来提供的,该装置的一般性质可以被表述为包括:处理器装置,其可以一般被表述为包括处理器和存储设备;输入装置,其被构造为向处理器装置提供一定数目的输入信号;输出装置,其被构造为从处理器装置接收一定数目的输出信号;以及存储设备具有存储在其中的一定数目的指令,该一定数目的指令当在处理器上执行时使该装置执行一定数目的操作,该一定数目的操作的一般性质可以被表述为包括:针对该人的一定数目的睡眠时段中的每个睡眠时段,确定一定数目的睡眠呼吸紊乱(SDB)严重性值,该一定数目的SDB严重性值中的每个SDB严重性值至少部分地基于对应有效海拔值和CSA处理的对应剂量;针对给定的有效海拔,至少部分地基于该一定数目的睡眠呼吸紊乱(SDB)严重性值的至少子集来确定CSA处理的优选剂量,在该优选剂量处可能的SDB严重性值不大于预定的SDB严重性值;以及生成至少部分地基于剂量的输出。
本发明的这些和其它目的、特征和特性、以及结构的相关元件的操作方法和功能、以及部分的组合和制造的经济性将在参考附图考虑以下描述和所附权利要求后变得更加明显,所有附图形成本说明书的一部分,其中同样的附图标记在各个附图中表示对应的部分。然而,应当清楚地理解,附图仅用于说明和描述的目的,并且不旨在作为对本发明的限制的限定。
附图说明
图1是根据所公开和要求保护的构思的一个方面的用于诊断高海拔诱发的睡眠呼吸紊乱的***的框图;
图2是根据所公开和要求保护的构思的一个方面的用于自动推荐用于高海拔诱发的睡眠呼吸紊乱的治疗的剂量的***的框图;
图3是具有曲线拟合的每日SDB严重性对海拔的示例图表,其中人在高于4000英尺的有效高度处经历显著的高海拔诱发的SDB;
图4是具有曲线拟合的每日SDB严重性对海拔的示例图表,其中人对海拔较不敏感并且在高于9500英尺的有效高度处经历显著的高海拔诱发的SDB;
图5是具有曲线拟合的每日SDB严重性对海拔的示例图表,其中人在任何海拔处都经历显著的SDB,并且在高于5000英尺的有效高度处具有SDB(海拔诱发的睡眠呼吸紊乱)的显著升高;
图6描绘了根据所公开和要求保护的构思的装置;
图7描绘了根据所公开和要求保护的构思的改进的方法;以及
图8描绘了根据所公开和要求保护的构思的另一改进的方法。
具体实施方式
如本文所使用的,单数形式的“一”、“一个”和“该”包括复数指代,除非上下文另有明确说明。如本文所使用的,两个或更多个部分或部件被“耦合”的表述将意味着部分被直接地或间接地(即,通过一个或多个中间部分或部件)联接或一起操作,只要发生链接。如本文所使用的,“直接耦合”意味着两个元件彼此直接接触。如本文所使用的,“固定地耦合”或“固定”意味着两个部件被耦合以便作为一体移动,从而保持相对于彼此的恒定定向。
如本文所使用的,词语“单式”意味着部件被创建为单个件或单元。也就是说,包括分开创建并且然后耦合在一起作为单元的件的部件不是“单式”部件或主体。如本文所采用的,两个或更多个部分或部件彼此“接合”的表述应意指部分直接地或通过一个或多个中间部分或部件对彼此施加力。如本文所采用的,术语“数目”应意指一个或大于一的整数(即,多个)。
本文使用的方向性短语,诸如例如但不限于顶部、底部、左、右、上、下、前、后及其派生词,涉及附图中示出的元件的定向,并且不限制权利要求,除非在其中明确记载。
图1和图2中所示的所公开和要求保护的构思包括若干不同的模块,诸如睡眠呼吸紊乱(SDB)检测模块、海拔相关模块、治疗剂量/功效建模模块和剂量预测模块。
***架构
在***仅提供诊断的一个实施例中,在图1中一般性地描绘了示出***的部件的框图。在***提供针对海拔诱发的睡眠呼吸紊乱的自动滴定治疗的另一个实施例中,参见图2中的框图。
睡眠呼吸紊乱检测模块
睡眠呼吸紊乱检测模块的意图是确定睡眠呼吸紊乱的存在和严重性,优选地在每晚的基础上。如本领域技术人员所知,存在一定数目的不同方法来评估睡眠呼吸紊乱严重性。如本文所采用的,表述“一定数目的”及其变体应广义地指代任何非零数量,包括一的数量。
生理传感器数据
在所公开和要求保护的构思中,生理传感器数据可以从光电体积描记器(PPG)和加速度计/陀螺仪获得,光电体积描记器(PPG)具有用于监测脉动血容积变化以及SpO2两者的适当电磁频谱分量,加速度计/陀螺仪用于测量诸如智能手表或其它可穿戴设备的可穿戴形状因子中的体动记录。在一些实施例中,仅测量提及的信号的子集。备选实施例可以使用不同的传感器配置,诸如通过使用麦克风、光学传感器、压电传感器等。
问卷数据
在所公开和要求保护的构思中,从人收集睡眠质量问卷数据。示例性的问题包括:“您认为您的夜晚睡眠使精力恢复得如何?”和“您花多长时间睡着?”。也可以使用类似地评估睡眠质量或睡眠质量的影响的其它问题。在其它实施例中,不需要主观用户数据。“您认为您的夜晚睡眠使精力恢复得如何?”的标度的示例可以是编号为针对“糟糕”的0到针对“优秀”的10的一系列框。
SDB数据输出
在所公开和要求保护的构思中,SDB数据是数字严重性标度,该数字严重性标度包括SDB严重性的客观量度(Obj.SDB Measure)和睡眠质量的主观量度(Subj.SDB Measure)的函数。在示例性实施例中,根据以下等式1组合客观和主观量度:
SDB严重性=min(((min(Obj.SDB Measure,50)/5)+(10-Subj.SDB Measure)/5),10)
在该实施例中,组合等式1的目的是允许客观和主观SDB量度两者影响SDB严重性加权,并以十分制标度提供标度输出。这允许由较少量的客观SDB造成的对他们的睡眠具有高度主观不满意的人仍然被适当地处理。例如,在该实施例中,高水平的SDB严重性(即“10”的水平)表示更大的严重性(例如AHI>=50或AHI为40,具有“糟糕”的夜晚睡眠),并且低水平的SDB严重性是优选的。还考虑用于组合主观SDB量度和客观SDB量度的其它函数。然而,重申,所公开和要求保护的构思预见到仅与客观数据组合或仅与主观数据组合来使用有效海拔。
客观SDB量度
在所公开和要求保护的构思中,处理PPG/SpO2和体动记录信号以确定中枢性呼吸暂停指数(CAI),即每小时睡眠的中枢性呼吸暂停的数目。在另一个所公开和要求保护的构思中,使用全呼吸暂停/呼吸不足指数(AHI)。为了确定CAI或AHI,***处理PPG和加速计传感器以确定觉醒、呼吸停止和氧饱和度降低的指示。在其它实施例中,仅使用SpO2信号以便确定针对客观SDB量度的氧饱和度降低指数(ODI)。可以用于客观睡眠呼吸紊乱严重性的其它量度包括觉醒(例如,作为心率加速的数目的觉醒指数等)、睡眠片断化(例如,醒来的数目)、睡眠开始之后的醒来(WASO,其通常被测量为在最初入睡之后醒来的总分钟数)等的指数。
主观SDB量度
在所公开和要求保护的构思中,主观SDB量度是对单个问题的回答,该单个问题诸如为:“在零到十的标度上,您认为您昨晚的睡眠使精力恢复得如何?”。在其他实施例中,询问一定数目的问题,并且主观SDB量度是对该一定数目的问题的评分合计响应。被询问以确定主观SDB量度的问题可以与诸如警觉性、疲劳等的白天功能和/或睡眠质量/满意度有关,并且问题可以在一天中被询问一次或多次。
海拔相关模块
海拔相关模块的目的是确定人有可能遭受预定水平的SDB的海拔,该预定水平的SDB典型地将是显著水平的SDB。海拔相关模块还有利地确定可以外插和内插的函数,以便确定在不同海拔处的SDB严重性的预测程度。海拔相关模块将SDB严重性和确定SDB严重性的海拔的量度作为输入。海拔相关模块确定SDB的严重性超过(或预计超过)预定水平的严重性的海拔。在所公开和要求保护的构思中,该预定水平是十分制标度中的二,这将是AHI增加大约10,这取决于白天的影响。
图3中所示的示例描绘了行进到不同海拔的人的每日SDB严重性评级和对应海拔。以下示例中的人在高于4000英尺的任何海拔处具有显著的海拔诱发的睡眠呼吸紊乱。
图4中所示的示例描绘了行进到不同海拔的另一个人的每日SDB严重性评级和海拔。图4示例中的人对海拔较不敏感,并且仅在高于9500英尺处示出海拔诱发的睡眠呼吸紊乱的迹象。
图5中所示的另一个示例描绘了行进到不同海拔的又一个人的每日SDB严重性评级和海拔。图5示例中的人在任何海拔处都具有显著的SDB,并且在高于5000英尺处具有SDB(海拔诱发的睡眠呼吸紊乱)的显著升高,注意到这是由于预计的SDB严重性增加至少两个单位。
在所公开和要求保护的构思中,SDB相关模块使用最小平方误差方法根据海拔来导出SDB严重性的示例性二次曲线拟合。诸如指数、幂等的其它曲线形状因子以及其它曲线拟合方法也在所公开和要求保护的构思的范围内,包括分段线性和非线性等。
海拔数据
在所公开和要求保护的构思中,海拔数据由可穿戴设备上的大气压力传感器提供,以估计SDB严重性度量被确定的夜晚的当前有效海拔。在该实施例中,以kPa为单位测量大气压力,并将大气压力与有效海拔相关(例如,海平面=101kPa,5000英尺海拔=84.3kPa,10000英尺海拔=69.7kPA等)。在其它实施例中,大气压力或海拔通过其他手段提供,该其他手段包括GPS、直接用户数据输入、与诸如智能电话的另一设备的通信等。
高海拔诱发的SDB诊断和用户通知
在所公开和要求保护的构思中,在该人处于比根据海拔相关模块预测他们具有显著的海拔诱发的SDB的海拔更大的海拔处的任何时间通知该人,该海拔相关模块确定该人处于SDB的升高的风险中。通知的示例包括智能电话或智能手表通知、电子邮件等。在一些实施例中,仅在该人接近习惯性就寝时间时做出通知。在其他实施例中,向该人呈现由相关模块准备的数据的报告以呈现给医师,并且通过示例的方式,该报告可以看起来像图3-图5中所示的图表,以便于治疗的处方,诸如乙酰唑胺。
剂量功效建模模块
在还提供治疗剂量的实施例中,剂量功效建模模块将SDB严重性、当前有效海拔和当前剂量作为输入。该模块的意图是确定可以从中确定治疗的适当剂量的函数。理想地,建议实现功效所需的最小剂量,使得可以减轻副作用(对于药理学治疗)或使得可以节省氧气(对于低流量氧疗)。
剂量数据
在所公开和要求保护的构思中,每日剂量由人手动提供,即,Diamox的剂量为125mg或2LPM的低流量氧气。在其它实施例中,诸如通过氧气输送设备或药物分配器自动提供剂量信息。
个性化剂量模型
在所公开和要求保护的构思中,用于导出在给定海拔和剂量处的预计SDB的剂量模型如下(等式2),等式2采用等于处于海平面的人的SDB严重性的最小SDB严重性“C”。等式2还考虑了有效海拔(Altitude)和SDB治疗的剂量(Dose)。
SDB严重性=max((A*Altitude2+B*Altitude-D*Dose),0)+C
在等式2中,系数A和B是由曲线拟合软件导出的曲线拟合系数,或以其它方式导出。还预见到该等式的其它形式,包括非线性函数。
在所公开和要求保护的构思中,个性化剂量模型具有来自具有相似海拔敏感性(SDB>阈值的海拔)的其他人的预限定数据,以便提供初始模型。这样的初始数据集在开发从人的SDB严重性获得的针对该人的数据之前被使用,该人的SDB严重性基于人的对应有效海拔和剂量值以及在海平面处的SDB严重性。在该实施例中,针对人的模型利用新数据连续更新并通过卡尔曼滤波生成。在另一实施例中,使用最小平方误差估计来生成模型。
剂量预测模块
剂量预测模块的目的是向人提供推荐的剂量,以便针对给定的有效海拔改善高海拔诱发的SDB。在所公开和要求保护的构思中,个性化剂量模块和当前有效海拔用于确定SDB严重性将不大于在海平面处的SDB严重性加一的剂量。在其他实施例中,用于剂量的其他阈值也是可能的。
剂量用户通知
在所公开和要求保护的构思中,在人处于比根据海拔相关模块预测他们具有显著的海拔诱发的SDB的海拔更大的海拔处的任何时间通知该人。这样的通知可以指示该人处于SDB的升高的风险中,意味着SDB严重性高于预定阈值或预定值,并且可以进一步指示为了改善症状将期望的适当的治疗剂量。通知的示例包括智能电话或智能手表通知、电子邮件等。在一些实施例中,仅在人接近习惯性就寝时间时做出通知。在其他实施例中,该通知是在该人被指示(例如通过自我报告或以其他方式)服药时的时间做出的。在其他实施例中,向该人呈现由剂量预测模块准备的数据的报告以呈现给医师,以便于治疗的处方或治疗的剂量范围(例如乙酰唑胺)。
装置和方法
在图6中以示意性方式描绘了根据所公开和要求保护的构思的改进的装置4。装置4可以被采用于执行同样根据所公开和要求保护的构思的改进的方法100和改进的方法200,并且改进的方法100和改进的方法200的至少一部分在图7和图8中以示意性方式描绘。装置4可以被表征为包括处理器装置8,处理器装置8可以被描述为包括彼此连接的处理器12和存储设备16。存储设备16采用非瞬态存储介质的形式,具有存储在其中的一定数目的例程20,该一定数目的例程同样采用非瞬态存储介质的形式,并且包括当在处理器12上执行时使装置4执行诸如本文别处提到的某些操作的指令。如本文别处所述,装置4可以采用各种形式中的任一种,并且可以采用诸如智能手表等的可穿戴设备的形式,并且同样可以采用蜂窝电话等的形式。
装置4可以被描述为进一步包括向处理器12提供输入信号的输入装置24和从处理器12接收输出信号的输出装置28。输入装置24可以被描述为包括各种输入部件中的任一种,并且输出装置28同样可以被描述为包括各种输出部件中的任一种。例如,如果装置4包括触摸屏,则输出装置28可以被描述为包括该触摸屏的视觉显示器,并且输入装置24可以被描述为包括位于该视觉显示器顶部的触敏覆盖物。
输入装置24可以被描述为包括多种多样的监测设备,诸如(通过示例的方式,但不限于)PPG监测设备32、大气压力监测设备36、GPS监测设备40、加速计/陀螺仪44、以及诸如麦克风、光学传感器、压电传感器等的各种其他监测设备中的任一种,由输入装置24将这些输入信号中的每个输入信号作为输入信号输入到处理器12。
输出装置28包括一定数目的输出设备,该一定数目的输出设备包括视觉显示器52和控制致动器56。视觉显示器52可以在视觉上描绘例如图3-图5的主题,和/或可以以处方的形式描绘对临床医生的指令。
控制致动器56可以多种多样的方式中的任一种来使用,诸如提供个性化睡眠治疗。在这点上,可以理解,控制致动器56和输入装置24结合处理器装置8和例程20可以形成闭环控制***,该闭环控制***使定制的处方剂量适于该人或者使氧气流速适于该人。例程20的其他执行方法可以包括机器学习模块等,以便以实现的简单性为代价来提高用户的个性化准确度。
在图7中一般性地描绘了根据所公开和要求保护的构思的改进的方法100。处理如在110处以确定一定数目的SDB严重性值和对应有效海拔值开始。在这点上,应当理解,有效海拔值典型地是当前可以存在的并且可以是人所处的地方的大气压力的形式。
处理如在120处以确定人有可能遭受预定水平的SDB严重性的有效海拔继续。预定水平的SDB严重性可以是诸如本文其他地方所描述的或者可以以其他方式建立。处理如在130处以生成输出继续,例如,该输出可以是诸如图3-图5中一般性地描绘的图表。
在图8中一般性地描绘根据所公开和要求保护的构思的另一改进的方法200。处理如在210处以确定一定数目的SDB严重性值开始,每个SDB严重性值至少部分地基于对应有效海拔值和CSA处理的剂量。处理如在220处以针对给定的海拔确定CSA处理的优选剂量继续,在该优选剂量处可能的SDB严重性值不大于预定的SDB严重性值。处理如在230处以生成输出继续。
在权利要求书中,置于括号内的任何附图标记不应被解释为限制权利要求。词语“包括”或“包含”不排除权利要求中所列出的元件或步骤之外的元件或步骤的存在。在列举了若干装置的设备权利要求中,这些装置中的若干装置可以由同一项硬件来体现。元件前面的词语“一”或“一个”不排除多个这种元件的存在。在列举了若干装置的任何设备权利要求中,这些装置中的若干装置可以由同一项硬件来体现。在相互不同的从属权利要求中记载了某些元件的仅有事实并不指示这些元件不能组合使用。
尽管已经基于当前被认为是最实用和优选的实施例、出于说明的目的详细描述了本发明,但是应当理解,这样的细节仅用于该目的,并且本发明不限于所公开的实施例,而是相反,旨在覆盖在所附权利要求的精神和范围内的修改和等同布置。例如,应当理解,本发明预见到,在可能的程度上,任何实施例的一个或多个特征可以与任何其他实施例的一个或多个特征组合。
Claims (19)
1.一种对人的海拔诱发的中枢性睡眠呼吸暂停(CSA)进行建模的方法,包括:
针对所述人的一定数目的睡眠时段中的每个睡眠时段,确定一定数目的睡眠呼吸紊乱(SDB)严重性值和一定数目的有效海拔值,所述一定数目的SDB严重性值中的每个SDB严重性值对应于所述一定数目的有效海拔值中的有效海拔值;
至少部分地基于所述一定数目的SDB严重性值的至少子集和所述一定数目的有效海拔值的至少子集,确定所述人有可能遭受预定水平的SDB严重性的有效海拔;以及
生成至少部分地基于所述有效海拔的输出。
2.根据权利要求1所述的方法,其中所述SDB严重性值中的至少一些SDB严重性值各自至少部分地基于SDB严重性的客观量度和SDB严重性的主观量度中的至少一者。
3.根据权利要求1所述的方法,其中所述SDB严重性值中的至少一些SDB严重性值各自至少部分地基于SDB严重性的客观量度和SDB严重性的主观量度两者。
4.根据权利要求1所述的方法,进一步包括:生成表示所述人处于所述有效海拔处或处于高于所述有效海拔处的通知,作为所述输出。
5.根据权利要求4所述的方法,进一步包括:在接近所述人的习惯性就寝时间的时间生成所述通知。
6.一种确定用于人的海拔诱发的中枢性睡眠呼吸暂停(CSA)处理的剂量的方法,包括:
针对所述人的一定数目的睡眠时段中的每个睡眠时段,确定一定数目的睡眠呼吸紊乱(SDB)严重性值,所述一定数目的SDB严重性值中的每个SDB严重性值至少部分基于对应有效海拔值和CSA处理的对应剂量;
针对给定的有效海拔,至少部分地基于所述一定数目的睡眠呼吸紊乱(SDB)严重性值的至少子集来确定所述CSA处理的优选剂量,在所述优选剂量处可能的SDB严重性值不大于预定的SDB严重性值;以及
生成至少部分地基于所述剂量的输出。
7.根据权利要求6所述的方法,其中所述优选剂量是所述CSA处理的最小剂量,在所述最小剂量处所述可能的SDB严重性值不大于所述预定的SDB严重性值。
8.根据权利要求6所述的方法,进一步包括:生成表示所述优选剂量的通知,作为所述输出。
9.根据权利要求8所述的方法,进一步包括:在接近所述人的习惯性就寝时间的时间生成所述通知。
10.根据权利要求8所述的方法,其中所述通知进一步表示所述人处于所述给定的有效海拔处或处于高于所述给定的有效海拔处。
11.根据权利要求6所述的方法,其中所述一定数目的SDB严重性值中的至少一些SDB严重性值中的每个SDB严重性值进一步至少部分地基于处于海平面的所述人的SDB严重性值。
12.根据权利要求6所述的方法,进一步包括:在至少部分地基于所述一定数目的睡眠呼吸紊乱(SDB)严重性值的所述至少子集来确定所述优选剂量之前,至少部分地基于数据集来确定初始优选剂量,所述数据集包括针对具有海拔诱发的CSA的一定数目的其他个体的一个或多个SDB严重性值和一个或多个对应有效海拔值以及所述CSA处理的一个或多个对应剂量。
13.一种被构造为确定用于人的海拔诱发的中枢性睡眠呼吸暂停(CSA)处理的剂量的装置,包括:
处理器装置,其包括处理器和存储设备;
输入装置,其被构造为向所述处理器装置提供一定数目的输入信号;
输出装置,其被构造为从所述处理器装置接收一定数目的输出信号;以及
所述存储设备具有存储在其中的一定数目的指令,所述一定数目的指令当在所述处理器上执行时使所述装置执行一定数目的操作,所述一定数目的操作包括:
针对所述人的一定数目的睡眠时段中的每个睡眠时段,确定一定数目的睡眠呼吸紊乱(SDB)严重性值,所述一定数目的SDB严重性值中的每个SDB严重性值至少部分地基于对应有效海拔值和CSA处理的对应剂量;
针对给定的有效海拔,至少部分地基于所述一定数目的睡眠呼吸紊乱(SDB)严重性值的至少子集来确定所述CSA处理的优选剂量,在所述优选剂量处可能的SDB严重性值不大于预定的SDB严重性值;以及
生成至少部分地基于所述剂量的输出。
14.根据权利要求13所述的装置,其中所述优选剂量是所述CSA处理的最小剂量,在所述最小剂量处所述可能的SDB严重性值不大于所述预定的SDB严重性值。
15.根据权利要求13所述的装置,其中所述操作进一步包括:生成表示所述优选剂量的通知,作为所述输出。
16.根据权利要求15所述的装置,其中所述操作进一步包括:在接近所述人的习惯性就寝时间的时间生成所述通知。
17.根据权利要求15所述的装置,其中所述通知进一步表示所述人处于所述给定的有效海拔处或处于高于所述给定的有效海拔处。
18.根据权利要求13所述的装置,其中所述一定数目的SDB严重性值中的至少一些SDB严重性值中的每个SDB严重性值进一步至少部分地基于处于海平面的所述人的SDB严重性值。
19.根据权利要求13所述的装置,其中所述操作进一步包括:在至少部分地基于所述一定数目的睡眠呼吸紊乱(SDB)严重性值的所述至少子集来确定所述优选剂量之前,至少部分地基于数据集来确定初始优选剂量,所述数据集包括针对具有海拔诱发的CSA的一定数目的其他个体的一个或多个SDB严重性值和一个或多个对应有效海拔值以及所述CSA处理的一个或多个对应剂量。
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