CN116077368A

CN116077368A - Repairing composition containing palmitoyl tetrapeptide-7, and preparation method and application thereof

Info

Publication number: CN116077368A
Application number: CN202310137329.1A
Authority: CN
Inventors: 林伟波
Original assignee: Guangzhou Xiyuan Cosmetics Co ltd
Current assignee: Guangzhou Xiyuan Cosmetics Co ltd
Priority date: 2023-02-20
Filing date: 2023-02-20
Publication date: 2023-05-09

Abstract

The invention provides a repairing composition containing palmitoyl tetrapeptide-7, which comprises, by weight, 2-5 parts of non-reducing disaccharide, 0.0001-0.5 part of palmitoyl tetrapeptide-7, 0.0001-0.5 part of palmitoyl tripeptide-8, 1-10 parts of plant extract, 1-5 parts of water-locking polysaccharide, 3-8 parts of humectant and 80-100 parts of water. The invention uses the two polypeptide components and the specific plant extracts and other components together, so that the active components fully play roles, and the prepared repairing composition can promote the generation of collagen, repair damaged cells and effectively remove free radicals, has excellent effects of resisting bacteria and inflammation, repairing skin, resisting aging and oxidation and efficiently preserving moisture, has good stability, safety and efficiency, and mild and non-irritating components, and can be widely applied to the field of cosmetics.

Description

Repairing composition containing palmitoyl tetrapeptide-7, and preparation method and application thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to a repairing composition containing palmitoyl tetrapeptide-7, and a preparation method and application thereof.

Background

Along with the phenomena of large working pressure, accelerated life rhythm and poor eating habit, more and more people have skin sebum secretion disorder, unbalanced water and oil, skin inflammatory reaction, red swelling, pain and itching and the like, and local pigmentation and acne pits can be formed after inflammation is eliminated. These skin problems are all related to abnormal sebaceous gland secretion, insufficient skin water retention capacity, eating habits, environmental factors, improper use of cosmetics, and the like. With the continuous development of daily chemical technology, natural cosmetics are favored because of the characteristics of high efficiency, safety, no stimulation and the like.

Chinese patent CN114129496a discloses a formulation and preparation method of a repairing and soothing gel, comprising: water, methyl propylene glycol, butylene glycol, glycerol polyether-26, polyglycerol-10, trehalose, golden chamomile extract, herba Menthae extract, herba Portulacae extract, pelargonium graveolens extract, radix Sophorae Flavescentis extract, glycerol, p-hydroxyacetophenone, aloe vera extract, 1, 2-hexanediol, herba Leonuri flower leaf extract, hydrolyzed sclerotium gum, octanoic acid hydroxamic acid, carbomer, triethanolamine, sodium hyaluronate, and sodium polyacrylate. Can remove makeup gently, clean, purify skin and remove acne for repair. However, it contains various thickening agents and antiseptic components and still has certain irritation.

A safe and efficient repairing composition which uses natural plant sources and has good stability is developed and applied to the field of cosmetics, and is still the focus of current research.

Disclosure of Invention

Aiming at the problems, the invention provides a repairing composition containing palmitoyl tetrapeptide-7, which has excellent effects of resisting bacteria and inflammation, repairing skin, resisting aging and oxidization and efficiently moisturizing, has good stability, is safe and efficient, has mild and no stimulation components, and can be widely applied to the field of cosmetics.

The repairing composition containing palmitoyl tetrapeptide-7 comprises, by weight, 2-5 parts of non-reducing disaccharide, 0.0001-0.5 part of palmitoyl tetrapeptide-7, 0.0001-0.5 part of palmitoyl tripeptide-8, 1-10 parts of plant extract, 1-5 parts of water-locking polysaccharide, 3-8 parts of humectant and 80-100 parts of water.

Preferably, the repairing composition containing palmitoyl tetrapeptide-7 comprises, by weight, 2-5 parts of non-reducing disaccharide, 0.1-0.5 part of palmitoyl tetrapeptide-7, 0.1-0.5 part of palmitoyl tripeptide-8, 3-7 parts of plant extract, 1-5 parts of water-locking polysaccharide, 4-6 parts of humectant and 80-100 parts of water.

Preferably, the non-reducing disaccharide is one of trehalose and sucrose.

Further preferably, the non-reducing disaccharide is trehalose.

Preferably, the plant extract is one or more of herba Menthae (MENTHA ARVENSIS) leaf extract, radix Sophorae Flavescentis (Sophora flavescens ait) root extract, herba Portulacae (Portulaca oleracea) extract, flos Matricariae Chamomillae (Crysanthemum) extract, aloe barbadensis (Aloe barbadensis) extract, pelargonium graveolens (PELARGONIUM GRAVEOLENS) extract, and Gelidium amansii (Gelidium amansium) extract.

Further preferably, the plant extract is herba Menthae (MENTHA ARVENSIS) leaf extract, radix Sophorae Flavescentis (Sophora flavescens) root extract, herba Portulacae (Portulaca oleracea) extract, flos Matricariae Chamomillae (Chamomillae) extract, aloe vera (Aloe bardanensis) extract, pelargonium graveolens (PELARGONIUM GRAVEOLENS) extract, gelidium amansii (Gelidium album) extract.

Further preferably, the mass ratio of the leaf extract of herba Menthae (MENTHAARVENSIS), root extract of radix Sophorae Flavescentis (SOPHORA ANGUSTIFOLIA), herba Portulacae (PORTULACA OLERACEA) extract, flos Matricariae Chamomillae (Crysanthemum) extract, aloe vera (Aloe barbadensis) extract, pelargonium graveolens (PELARGONIUM GRAVEOLENS) extract, and Gelidium (Gelidium marianum) extract is (7-9): (1-3): (6-8): (10-12): (3-5): (7-9): (2-5).

The herba Menthae (MENTHA ARVENSIS) leaf extract contains multiple components such as flavone, organic acid and amino acid, and has effects in relieving itching and softening skin; the radix sophorae flavescentis (SOPHORA ANGUSTIFOLIA) root extract is mainly matrine component, and has excellent effects of resisting bacteria, diminishing inflammation, promoting collagen production and the like; the purslane (PORTULACA OLERACEA) extract can effectively remove free radicals and has antibacterial and anti-inflammatory effects; the golden chamomile (Crysanthellumindicum) extract contains a large amount of triterpenes, and has excellent antibacterial, antiinflammatory, antiallergic effects; aloe barbadensis (Aloe barbadensis) extract is effective in promoting collagen synthesis, scavenging free radicals, moisturizing skin, and resisting aging; the pelargonium roseum (PELARGONIUM GRAVEOLENS) extract contains geraniol, citronellol, linalool and other components, and has excellent antibacterial, mite-removing and antioxidant effects; the Gelidium amansii (Gelidium amansii) extract contains a large amount of polysaccharide components, and has excellent anti-aging effect.

The inventors found that the mass ratio of several plant extract ingredients used in combination, especially when the leaf extract of peppermint (MENTHA ARVENSIS), the root extract of kuh-seng (SOPHORA ANGUSTIFOLIA), the extract of purslane (PORTULACA OLERACEA), the extract of chamomile (chrysanthum indicum), the extract of aloe vera (aloebadens), the extract of geranium (PELARGONIUM GRAVEOLENS), the extract of gella sativa (geliumcartaria) is (7-9): (1-3): (6-8): (10-12): (3-5): (7-9): and (2-5) has excellent antibacterial, anti-inflammatory, moisturizing and repairing effects, but has excellent stability. The inventors analyzed that it is possible to enhance the absorption of skin by the combined action of various active ingredients contained in the plant extract components, and that the composition viscosity was increased and the stable dispersion of active ingredients was enhanced by containing a large amount of calcium, potassium, sodium, ammonium, etc. components of polysaccharide sulfate consisting of galactose and dehydrated galactose in the extract of gelidium sativum (gelinium album). Particularly, when the trehalose and the water-locking polysaccharide in the coordination system are used together, the trehalose can act together with the active ingredients to form a stable protective film structure, so that the stable dispersion of the active ingredients is further enhanced. However, the inventors found that the polysaccharide component content cannot be too high, otherwise the viscosity is too high, the viscosity is easy to generate greasy feeling during use, and phenomena such as oxidation and the like can be generated, and the stable storage is affected.

Preferably, the water-locking polysaccharide comprises, by weight, 50-55 parts of saccharide isomers, 2-4 parts of small molecular alcohols and 35-45 parts of water.

Preferably, the small molecule alcohols are butanediol and 1, 2-hexanediol.

It is further preferable that the mass ratio of the butanediol to the 1, 2-hexanediol is (2-3): 0.5.

Preferably, the humectant is butylene glycol and glycerin.

Further preferably, the mass ratio of the butanediol to the glycerol is (1.5-2.5): 1.

In another aspect, the invention provides a method for preparing a repair composition containing palmitoyl tetrapeptide-7, comprising the following steps:

s1: mixing non-reducing sugar, palmitoyl tetrapeptide-7, palmitoyl tripeptide-8 and water locking polysaccharide, adding into 35-45deg.C water, and stirring to obtain mixture A;

s2: adding the plant extract and humectant into 35-45deg.C water, and stirring to obtain mixture B;

s3: and uniformly mixing the mixture A and the mixture B to obtain the repairing composition containing the palmitoyl tetrapeptide-7.

Preferably, the stirring rate in the steps S1 and S2 is 40-50r/min.

In a third aspect, the present invention provides the use of a palmitoyl tetrapeptide-7 containing repair composition in cosmetics.

Compared with the prior art, the invention has the following beneficial effects:

the invention uses the two polypeptide components and the specific plant extracts and other components together, so that the active components fully play roles, and the prepared repairing composition can promote the generation of collagen, repair damaged cells and effectively remove free radicals, has excellent effects of resisting bacteria and inflammation, repairing skin, resisting aging and oxidation and efficiently preserving moisture, has good stability, safety and efficiency, and mild and non-irritating components, and can be widely applied to the field of cosmetics.

Detailed Description

For a better understanding of the present invention, the following detailed description of the invention will be made with reference to the examples, however, it should be understood that these examples, test examples, are for illustrative purposes only and are not intended to limit the scope of the present invention.

Examples

Example 1

The embodiment provides a repairing composition containing palmitoyl tetrapeptide-7, which comprises, by weight, 3.5 parts of non-reducing disaccharide, 0.25 part of palmitoyl tetrapeptide-7, 0.25 part of palmitoyl tripeptide-8, 5 parts of plant extract, 3 parts of water-locking polysaccharide, 5 parts of humectant and 90 parts of water.

The non-reducing disaccharide is trehalose, purchased from the Guangzhou Tinlan Biotechnology Co., ltd;

palmitoyl tetrapeptide-7 and palmitoyl tripeptide-8 were purchased from new materials technologies, inc. Hua Feng, guangzhou;

the mass ratio of the plant extract is 8:2:7:11:4:8:3.5 herba Menthae (MENTHA ARVENSIS) leaf extract, radix Sophorae Flavescentis (SOPHORA ANGUSTIFOLIA) root extract, herba Portulacae (PORTULACA OLERACEA) extract, flos Matricariae Chamomillae (Chamomillae) extract, aloe vera (Aloe bardansis) extract, pelargonium graveolens (PELARGONIUM GRAVEOLENS) extract, gelidium album (Gelidium album) extract; plant extracts were purchased from elschima (zhugui) biotechnology limited.

The water-locking polysaccharide comprises 52 parts of saccharide isomer (CAS number is 100843-69-4), 3 parts of small molecular alcohol and 40 parts of water in parts by weight; the small molecular alcohol is butanediol and 1, 2-hexanediol with the mass ratio of 2.5:0.5.

The humectant is butanediol and glycerol with a mass ratio of 2:1.

In another aspect, the present embodiment provides a method for preparing a repair composition containing palmitoyl tetrapeptide-7, which specifically includes the following steps:

s1: mixing non-reducing sugar, palmitoyl tetrapeptide-7, palmitoyl tripeptide-8 and water locking polysaccharide, adding into 60 parts by weight of water at 35-45deg.C, and stirring at 40-50r/min for 10min to obtain mixture A;

s2: adding the plant extract and humectant into 30 parts by weight of water at 35-45deg.C, and stirring at 40-50r/min for 10min to obtain mixture B;

Example 2

The embodiment provides a repairing composition containing palmitoyl tetrapeptide-7, which comprises, by weight, 2 parts of non-reducing disaccharide, 0.1 part of palmitoyl tetrapeptide-7, 0.1 part of palmitoyl tripeptide-8, 3 parts of plant extract, 1 part of water-locking polysaccharide, 4 parts of humectant and 90 parts of water.

The specific raw material sources are the same as in example 1.

In another aspect of this example, a method for preparing a palmitoyl tetrapeptide-7-containing repair composition is provided, and the specific steps are the same as in example 1.

Example 3

The embodiment provides a repairing composition containing palmitoyl tetrapeptide-7, which comprises, by weight, 5 parts of non-reducing disaccharide, 0.5 part of palmitoyl tetrapeptide-7, 0.5 part of palmitoyl tripeptide-8, 7 parts of plant extract, 5 parts of water-locking polysaccharide, 6 parts of humectant and 90 parts of water.

The specific raw material sources are the same as in example 1.

Comparative example 1

The present example provides a repair composition containing palmitoyl tetrapeptide-7, and the specific embodiment is the same as example 1, and differs from example 1 in that the plant extract is in a mass ratio of 8:2:7:11:4:8, a herba Menthae (MENTHA ARVENSIS) leaf extract, a radix Sophorae Flavescentis (SOPHORA ANGUSTIFOLIA) root extract, a herba Portulacae (PORTULACA OLERACEA) extract, a flos Matricariae Chamomillae (Chamomillae) extract, an aloe vera (Aloe bardanensis) extract, and a Pelargonium graveolens (PELARGONIUM GRAVEOLENS) extract.

Comparative example 2

This example provides a composition comprising palmitoyl tetrapeptide-7, and the specific embodiment is the same as example 1, except that trehalose is 1 part as compared with example 1.

Comparative example 3

This example provides a palmitoyl tetrapeptide-7-containing repair composition, and the specific embodiment is the same as example 1, except that the humectant sugar is 1 part.

Performance testing

1. And (3) repairing effect test:

skin transepidermal water loss TEWL values were measured using the skin water loss test probe tewatter TM 300.

Testing the rate of percutaneous moisture loss: the measured value is remarkably reduced, which indicates that the skin percutaneous moisture loss rate is remarkably reduced, and the product is considered to have the effect of repairing the skin barrier.

Skin a value: the measured value is obviously reduced, which indicates that the redness degree of the skin is reduced, and the product is considered to have the repairing effect of improving the redness of the skin. a (rate of change) = (post-use average-pre-use average)/(pre-use average).

Selecting 31 subjects (male 5 and female 26) aged 19-60 years (average 41.03 years), and detecting skin transepidermal water loss TEWL value before and 7 days after the test sample is used by using a skin water loss test probe Tewatemeter (TM) 300; the smaller the TEWL value of the percutaneous moisture loss rate, the slower the percutaneous moisture loss.

The composition of example 1 was subjected to a repair effect test, and the test results are shown in table 1 below.

TABLE 1

2. Stability test:

the samples were placed in a 48℃constant temperature and humidity cabinet, a room temperature (25 ℃) and a-25℃constant temperature and humidity cabinet for 20 days, and then taken out to room temperature (25 ℃) and placed for 8 hours, and whether the composition was discolored, layered, precipitated solids or other adverse phenomena was observed. If no, marking as A; if the color is slightly layered, the color is marked as B; if significant delamination, discoloration or solid precipitation occurred, it was noted as C.

The repair effect test was performed for example 1.

The above performance tests were conducted on the repair compositions of examples 1 to 3 and comparative examples 1 to 3, and the test results are shown in Table 2 below.

TABLE 2

Examples	48℃	Room temperature (25 ℃ C.)	-25℃
				Example 1	A	A	A
Example 2	A	A	A
				Example 3	A	A	A
Comparative example 1	C	B	B
				Comparative example 2	B	A	B
Comparative example 3	B	B	C

Claims

1. The repairing composition containing palmitoyl tetrapeptide-7 is characterized by comprising, by weight, 2-5 parts of non-reducing disaccharide, 0.0001-0.5 part of palmitoyl tetrapeptide-7, 0.0001-0.5 part of palmitoyl tripeptide-8, 1-10 parts of plant extract, 1-5 parts of water-locking polysaccharide, 3-8 parts of humectant and 80-100 parts of water.

2. A palmitoyl tetrapeptide-7 containing repairing composition according to claim 1, wherein the non-reducing disaccharide is one of trehalose and sucrose.

3. The composition of claim 1, wherein the plant extract is one or more of peppermint leaf extract, kuh-seng extract, purslane extract, chamomile extract, aloe vera extract, geranium extract, and gelsemium extract.

4. A composition according to claim 3, wherein the plant extract is a peppermint leaf extract, a kuh-seng extract, a purslane extract, a chamomile extract, an aloe vera extract, a geranium extract, a gella sativa extract.

5. The composition for repairing and protecting skin containing palmitoyl tetrapeptide-7 according to claim 4, wherein the mass ratio of the extract of peppermint leaf, the extract of kuh-seng, the extract of purslane, the extract of chamomile, the extract of aloe vera, the extract of geranium and the extract of gelsemium elegans is (7-9):

(1-3)：(6-8)：(10-12)：(3-5)：(7-9)：(2-5)。

6. the repairing composition containing palmitoyl tetrapeptide-7 according to claim 1, wherein the water-locking polysaccharide comprises 50-55 parts of saccharide isomer, 2-4 parts of small molecular alcohol and 35-45 parts of water in parts by weight.

7. A palmitoyl tetrapeptide-7 containing repair composition according to claim 1, wherein the humectant is butylene glycol and glycerin.

8. A repair composition comprising palmitoyl tetrapeptide-7 according to claim 7, wherein the mass ratio of butanediol to glycerol is (1.5-2.5): 1.

9. A method for preparing a repair composition comprising palmitoyl tetrapeptide-7 according to any one of claims 1 to 8, comprising the specific steps of:

10. Use of a maintenance composition comprising palmitoyl tetrapeptide-7 according to any one of claims 1 to 8 in cosmetics.