CN115844794A - Anti-aging composition, cosmetic containing anti-aging composition and application of cosmetic - Google Patents
Anti-aging composition, cosmetic containing anti-aging composition and application of cosmetic Download PDFInfo
- Publication number
- CN115844794A CN115844794A CN202211632796.3A CN202211632796A CN115844794A CN 115844794 A CN115844794 A CN 115844794A CN 202211632796 A CN202211632796 A CN 202211632796A CN 115844794 A CN115844794 A CN 115844794A
- Authority
- CN
- China
- Prior art keywords
- extract
- composition
- aging
- aging composition
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and discloses an anti-aging composition, a cosmetic containing the anti-aging composition and application of the cosmetic. The anti-aging composition comprises the following components in parts by weight: 0.01 to 3 portions of sesame sprout extract, 0.01 to 6 portions of wild soybean sprout extract, 0.05 to 9 portions of rice sprout extract, 0.01 to 10 portions of tuber melanosporum extract, 0.01 to 6.5 portions of rye seed extract and 65.5 to 99.91 portions of auxiliary agent. The anti-aging composition provided by the invention has the beneficial effects that the composition can effectively resist oxidation, inhibit MMP-9 expression, reduce skin collagen loss, promote cell proliferation and reduce wrinkle generation through the synergistic effect of the sesame sprout extract, the wild soybean sprout extract, the rice sprout extract, the tuber melanosporum extract and the rye seed extract, so that the skin aging is resisted, and the composition is mild and has no stimulation.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging composition, a cosmetic containing the anti-aging composition and application of the cosmetic.
Background
With the improvement of living standard and the rapid pace to aging society, people pay more and more attention to anti-aging maintenance, and the anti-aging market will lead the future. In fact, anti-aging cosmetics have also become the fastest growing and most potential category. According to research, the proportion of the anti-aging cosmetic in China reaches 23 percent, and the anti-aging cosmetic becomes the first major product.
With the rapid development of the cosmetic industry and the wide application of the green concept in various industries, people also put forward the requirements of pure nature, no toxic or side effect and the like on anti-aging cosmetics, which creates good basis and premise for the application of natural plant extracts in anti-aging cosmetics. The natural plant extract is added into cosmetics to realize the anti-aging function of the cosmetics, and the development trend of the cosmetics industry is formed. According to the characteristics of skin aging and the specific reasons for skin aging, the natural plant extract is added into the cosmetic, so that the cosmetic not only has the basic moisturizing function, but also can further smooth the skin, remove skin aging wrinkles and achieve the purpose of delaying skin aging. The plant extract has the advantages of natural safety and toxic and side effects, so that the plant extract is widely applied to anti-aging cosmetics as an active raw material.
Disclosure of Invention
In view of the above, the first objective of the present invention is to provide an anti-aging composition, which is capable of effectively resisting oxidation, inhibiting the expression of MMP-9, reducing the loss of collagen of skin, promoting cell proliferation, and reducing the generation of wrinkles, thereby resisting skin aging, and is mild and non-irritant. The second purpose of the invention is to provide an application of the composition containing the anti-aging agent. The third object of the present invention is to provide a cosmetic containing the antiaging composition.
In order to achieve the first object, the invention adopts the technical scheme that:
an anti-aging composition comprises the following components in parts by weight: 0.01 to 3 portions of sesame sprout extract, 0.01 to 6 portions of wild soybean sprout extract, 0.05 to 9 portions of rice sprout extract, 0.01 to 10 portions of tuber melanosporum extract, 0.01 to 6.5 portions of rye seed extract and 65.5 to 99.91 portions of auxiliary agent.
Further, the composition comprises the following components in parts by weight: 0.08 to 3 parts of sesame sprout extract, 1 to 6 parts of wild soybean sprout extract, 3 to 9 parts of rice germ extract, 1 to 10 parts of tuber melanosporum extract, 1 to 6.5 parts of rye seed extract and 65.5 to 93.92 parts of auxiliary agent.
Further, the composition comprises the following components in parts by weight: 0.08 to 2.5 parts of sesame sprout extract, 1 to 4 parts of wild soybean sprout extract, 3 to 8 parts of rice sprout extract, 1 to 7 parts of tuber melanosporum extract, 1 to 5 parts of rye seed extract and 73.5 to 93.92 parts of auxiliary agent. In the composition, the proportion of the components influences the effect of the composition, and researches show that the anti-aging effect of the composition is better within the preferable weight part range.
Further, the composition comprises the following components in parts by weight: 2.5 parts of sesame sprout extract, 2.5 parts of wild soybean sprout extract, 7.48 parts of rice sprout extract, 6 parts of tuber melanosporum extract, 4 parts of rye seed extract and 77.52 parts of auxiliary agent. The applicant has found unexpectedly in a large number of experiments that the anti-ageing effect of the composition according to the invention is optimal at this specific weight ratio.
The anti-aging composition is characterized in that the sesame sprout extract is extracted from the sprouting period of black sesame seeds and is used for inhibiting skin lipid oxidation and scavenging free radicals.
The anti-aging composition, wherein the wild soybean sprout extract is extracted from the black soybean seeds at the sprouting stage, and is used for promoting the proliferation of fibroblasts (p 8) and (p 10), inhibiting the expression of MMP-9 and reducing the loss of skin collagen.
The anti-aging composition as described above, wherein the rice germ extract is extracted at the germination stage of black rice seeds for preventing oxidation of hydroxyl group-induced proteins.
The anti-aging composition, wherein the Tuber melanosporum extract is extracted from truffle, and is used for removing excessive DHHP free radicals and hydroxyl free radicals in the body.
The anti-aging composition, wherein the rye seed extract is extracted from rye seeds, and is used for activating the formation of stress fibers and activating YAP/TAZ factors in dermis and epidermis, stimulating cell contraction, and activating epidermal renewal.
Furthermore, the auxiliary agent adopts one or a combination of two of a solvent and a preservative.
Further, the solvent is one or a composition of more than two of water, butanediol, 1, 3-propanediol or 1, 2-pentanediol.
Further, the preservative is a water-soluble preservative which is one or a combination of two of phenoxyethanol and p-hydroxyacetophenone.
The applicant found that the composition of the present invention has an excellent anti-aging effect due to the organic combination of the sesame sprout extract, the wild soybean sprout extract, the rice germ extract, the tuber melanosporum extract, the rye seed extract and the auxiliary agents.
A preparation method of an anti-aging composition comprises the steps of mixing a sesame sprout extract, a wild soybean sprout extract, a rice sprout extract, a tuber melanosporum extract, a rye seed extract and an auxiliary agent according to the parts by weight to obtain the anti-aging composition.
In order to achieve the second object, the invention adopts the technical scheme that:
the invention also provides application of the anti-aging composition in cosmetics.
In order to achieve the third object, the invention adopts the technical scheme that:
a cosmetic product comprising an anti-aging composition, comprising the anti-aging composition.
Further, the anti-aging composition accounts for 3 to 10 percent of the weight of the cosmetic containing the anti-aging composition.
Further, the anti-aging composition accounts for 8% by weight of the cosmetic containing the anti-aging composition.
Further, the cosmetic containing the anti-aging composition also comprises the following components in percentage by weight: 5 to 15 percent of humectant, 0.2 to 3 percent of thickener, 5 to 20 percent of fat-liquoring agent, 2.0 to 4.5 percent of emulsifier, 0.5 to 1.0 percent of preservative, 0.03 to 0.1 percent of chelating agent and the balance of deionized water.
Further, the humectant is one or a composition of more than two of glycerol, 1, 3-propylene glycol, 1, 2-pentanediol or 1, 2-hexanediol;
further, the thickening agent is one or a composition of more than two of xanthan gum, carbomer or acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer;
the fat-imparting agent is one or a composition of more than two of shea butter, caprylic/capric triglyceride, isononyl isononanoate or triglyceride (ethyl hexanoate);
further, the emulsifier is one or a composition of more than two of cetearyl olive oleate, sorbitan olive oleate or polyglycerol-3 cetyl ether;
further, the preservative is one or a composition of more than two of glyceryl caprylate, phenoxyethanol and p-hydroxyacetophenone;
further, the chelating agent is disodium EDTA.
A preparation method of the cosmetic containing the anti-aging composition comprises the steps of accurately weighing, stirring, homogenizing, heating and cooling.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the sesame sprout extract, the wild soybean sprout extract, the rice sprout extract, the tuber melanosporum extract and the rye seed extract are combined together in an organic manner to realize synergistic interaction, so that the composition can effectively resist oxidation, inhibit MMP-9 expression, reduce skin collagen loss, promote cell proliferation and reduce wrinkles, and the prepared composition and cosmetics have excellent anti-aging effects.
Detailed Description
To better illustrate the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to specific examples.
In the following examples, sesame sprout extract, wild soybean sprout extract, rice sprout extract, tuber melanosporum extract, rye seed extract, and auxiliary agents were prepared by conventional methods or commercially available.
Examples 1 to 6 and comparative examples 1 to 10 each relate to an antiaging composition, and comparative examples 1 to 5 relate to one of the antiaging compositions, the compounding ratios are shown in Table 1;
table 1: antisenescence composition or its component (weight portion)
According to the formula composition shown in table 1, the sesame sprout extract, the wild soybean sprout extract, the rice sprout extract, the tuber melanosporum extract, the rye seed extract and the auxiliary agent are mixed according to the weight parts to obtain the composition.
1. Effect example 1
(1) The scavenging ability of the compositions obtained in examples 1 to 6 and comparative examples 1 to 10 for radicals was investigated, wherein the scavenging ability for DPPH radicals, superoxide anion radicals and hydroxyl radicals was mainly investigated; the results obtained are shown in table 2;
1. the test for DPPH radical scavenging ability comprises the following steps:
adding 3mL of phosphate buffer solution with the pH value of 6.8, 4mL of 0.4mmol/L of DPPH absolute ethyl alcohol solution and 0.2mL of sample to be detected into a 10mL centrifuge tube, fully mixing the solutions, centrifuging the mixture for 10min (5000 r/min) after 30min, taking supernatant, measuring the absorbance value at 517nm, performing parallel operation for 3 times, and taking an average value, wherein the clearance rate of the sample to DPPH free radicals is = [1- (A1-A2)/A3 ]. In the formula, A1 is the absorbance value of the DPPH solution after sample addition reaction, A2 is the absorbance value of the sample addition solution without adding DPPH (replacing with absolute ethyl alcohol), and A3 is the absorbance value of the sample addition solution without adding DPPH and the aqueous solution.
2. The test for superoxide anion inhibition comprises the following steps:
a buffer system (Tris-HCl-EDTA) with a pH value of 8.20 was prepared. Adding 0.6mL of sample to be detected into a 10mL centrifuge tube, adding 5.2mL of buffer solution, adding 0.045mol/L pyrogallol solution 0.2mL by using a pipette, quickly shaking up, quickly putting into a dry cuvette after 5min of reaction (time must be accurate), measuring the absorbance value at 325nm, and recording as A0, and measuring as A4 after 10 min. The absorbance values measured with distilled water instead of the sample were designated as B0 and B4, respectively. The average value was obtained by performing 3 parallel operations, and the inhibition rate of the sample on superoxide anion = [ (B4-B0) - (A4-A0) ]/(B4-B0).
3. The test for hydroxyl radical scavenging ability comprises the following steps:
1mL, 0.4mmol/L crystal violet, 3mL, 0.2mol/L pH7.4 phosphate buffer, 1mL, 0.001mol/L FeSO 4 Solution, 1mL of sample to be tested, was added to a 10mL centrifuge tube, and finally 1mL30% was added 2 O 2 Starting the reaction, centrifuging at 12000r/min for 5min after reacting for 1H at room temperature, taking supernatant, measuring the light absorption value at 510nm and recording as C, recording the light absorption value when the sample is replaced by distilled water as C1, and replacing the sample and H by distilled water 2 O 2 The absorbance was designated as C2. The mean values were taken 3 times in parallel and the hydroxyl radical clearance of the sample = (C-C1)/(C2-C1).
Table 2: tables showing radical scavenging abilities of products obtained in examples 1 to 6 and comparative examples 1 to 10
As can be seen from Table 2, the anti-aging compositions described in examples 1-6 of the present invention have strong ability to scavenge free radicals, and exhibit significant inhibition and scavenging effects on DPPH free radicals, superoxide anion free radicals and hydroxyl free radicals, wherein the removal rate on DPPH free radicals is up to 84.37% or more, preferably in examples 4-6; the inhibition rate of the superoxide anion free radicals reaches more than 83.13 percent; the hydroxyl radical clearance rate reaches over 86.92 percent; example 6 is optimal, and the DPPH free radical clearance rate reaches 86.71 percent; the inhibition rate on superoxide anion free radicals reaches 84.52 percent; the hydroxyl radical clearance rate reaches 89.74 percent; in addition, as can be seen from example 6 and comparative examples 1 to 10, under the same conditions, when any one of 5 components is used alone or any one of 5 components is not adopted, the radical clearance is significantly lower than that of the composition of the invention, the maximum DPPH radical clearance is only 64.42%, the maximum superoxide anion radical inhibition is only 57.72%, and the maximum hydroxyl radical clearance is 55.32%, further, the composition of the invention needs to achieve a significant anti-aging effect under the synergistic effect of the 5 compositions.
Examples 7 to 11 and comparative example 11
Examples 7 to 11 and comparative example 11 provided by the invention are all anti-aging emulsions, the composition table of the emulsions is shown in table 3, and data in the table are filled in percentage by mass.
The anti-aging composition in the composition table of the emulsion comprises the following components in parts by weight: 2.5 parts of sesame sprout extract, 2.5 parts of wild soybean sprout extract, 7.48 parts of rice sprout extract, 6 parts of tuber melanosporum extract, 4 parts of rye seed extract and 77.52 parts of auxiliary agent.
Ubiquinone in the composition table of the emulsion is a raw material recognized to have an anti-aging effect on the market, and is selected to be added into the emulsion as comparative example 11.
Table 3: composition tables of emulsions of control, examples 7 to 11 and comparative example 11
The preparation method of the emulsions in examples 7 to 11 and comparative example 11 comprises the following steps:
(1) putting water, EDTA-disodium, xanthan gum, carbomer, 1, 2-hexanediol and glycerol in the table 3 into an emulsifying pot, stirring and homogenizing uniformly, and stirring and heating to 80-85 ℃;
(2) adding cetearyl alcohol olive oleate, sorbitan olive oleate, shea butter, caprylic/capric triglyceride, and isononyl isononanoate, stirring and homogenizing for 5min, stirring at 80 deg.C, and maintaining the temperature for 20 min;
(3) cooling to 60 deg.C, adding 1, 3-propylene glycol and p-hydroxyacetophenone, and stirring;
(4) cooling to below 45 deg.C, adding the antiaging composition and ubiquinone, and stirring to obtain antiaging emulsion.
The preparation method of the control group was completely identical to the preparation methods of examples 7 to 11 and comparative example 11, except that the anti-aging composition and ubiquinone raw material were not added.
2. Effect example 2
The prepared control, examples 7 to 11 and comparative example 11 were subjected to stability test:
(1) the heat resistance test is that the product is kept still for one month at the temperature of 45 +/-2 ℃, and the appearance, the color and the smell of the product are observed;
(2) the cold resistance test is to stand for one month at the temperature of minus 18 +/-2 ℃ and observe the appearance, color and smell of the product;
(3) the cold and hot cyclicity test is that the materials are stored for 24 hours at the temperature of 45 ℃, normal temperature and minus 18 ℃ respectively, and are cycled for 7 times to observe the appearance, color and smell of the materials;
the test results showed that the prepared products of the control, examples 7 to 11 and comparative example 11 were good in stability, and heat-resistant, cold-resistant and did not give abnormal appearance, color and smell under cold and heat cycles.
3. Effect example 3
In the effect example, the anti-aging effect of the prepared products of the control group, examples 7 to 11 and comparative example 11 is researched in a manner of volunteer experiments; the method specifically comprises the following steps:
(1) Subject: 70 volunteers aged 35-55 years were selected and divided into 7 groups of 10 individuals for each group. The volunteers of each group respectively try a control group, examples 7 to 11 and a comparative example 11;
(2) Test samples and methods of use thereof: the volunteers used the product on their whole face for 28 days without using other skin care products after cleaning the face in the morning and evening every day.
(3) Test (experiment)Previously, the wrinkle area S of the facial skin of the tested subject before the test is measured by a Visinoid VL 650 wrinkle tester 0 : the change of the skin wrinkles and the change of the facial skin wrinkle area were obtained by software analysis.
(4) In the test, the volunteers used the test samples according to the method of use, and the wrinkle area S of the facial skin was measured by Visoline VL 650 wrinkle tester at 2 pm (ambient temperature 20 ℃ C., relative humidity 50%) every day t : the change of the skin wrinkles and the change of the facial skin wrinkle area were obtained by software analysis.
The skin wrinkle area reduction amount (%) is calculated (= (skin wrinkle area before test-average skin wrinkle area after test)/skin wrinkle area before test × 100%.
Finally, calculating the average fading rate of each group of wrinkles, and recording the fading rate as shown in table 4;
table 4: anti-wrinkle test Table for products obtained in control group, examples 7 to 11 and comparative example 11
As can be seen from Table 4, the anti-aging cosmetics provided in examples 7 to 11 of the present invention have a remarkable wrinkle reduction effect, wherein the wrinkle reduction effect is more remarkable in examples 8 to 11, and the average wrinkle reduction rate of examples 9 to 11 is more than 21.37%, which is 18.31% higher than the average ubiquinone wrinkle reduction rate of comparative example 1. Among them, examples 10 and 11 show that the addition of 8 parts of the antiaging composition is more effective than the addition of 10 parts of the antiaging composition in reducing wrinkles; therefore, the addition amount of the cosmetic is preferably 3 to 8 parts.
4. Mild testing
The control, examples 7-11 and comparative example 11 were tested for irritativeness using chick chorioallantoic membranes, and the results were rated 0, 1,2 and 3 for no coagulation, mild coagulation, moderate coagulation and severe coagulation, respectively. The test results are shown in Table 5.
TABLE 5 irritation results for the various groups of emulsions
As can be seen from Table 5, the test results of the emulsions in the control group and examples 7 to 11 are all mild blood coagulation, and the test result of the emulsion in the comparative example 11 is non-irritant, so that the test result of the emulsion in the comparative example 11 is severe irritation, which shows that the irritation of the cosmetic is not substantially affected after the anti-aging composition is added, and the mildness of the anti-aging composition is reflected.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The anti-aging composition is characterized by comprising the following components in parts by weight: 0.01 to 3 portions of sesame sprout extract, 0.01 to 6 portions of wild soybean sprout extract, 0.05 to 9 portions of rice sprout extract, 0.01 to 10 portions of tuber melanosporum extract, 0.01 to 6.5 portions of rye seed extract and 65.5 to 99.91 portions of auxiliary agent.
2. The anti-aging composition of claim 1, wherein: comprises the following components in parts by weight: 0.08 to 2.5 parts of sesame sprout extract, 1 to 4 parts of wild soybean sprout extract, 3 to 8 parts of rice germ extract, 1 to 7 parts of tuber melanosporum extract, 1 to 5 parts of rye seed extract and 73.5 to 93.92 parts of auxiliary agent.
3. The anti-aging composition according to claim 1 or 2, wherein the auxiliary agent is one or a combination of a solvent and a preservative.
4. The anti-aging composition according to claim 3, wherein the solvent is one or a combination of two or more of water, butylene glycol, 1, 3-propanediol, or 1, 2-pentanediol; the preservative is a water-soluble preservative which is one or a composition of two of phenoxyethanol and p-hydroxyacetophenone.
5. Use of the anti-aging composition according to any one of claims 1 to 4 in cosmetics.
6. A cosmetic containing an antiaging composition characterized by comprising the antiaging composition according to any one of claims 1 to 4.
7. The cosmetic with anti-aging composition according to claim 6, wherein the anti-aging composition is present in the cosmetic with anti-aging composition in an amount of 3 to 10% by weight.
8. The cosmetic with anti-aging composition according to claim 6, wherein the anti-aging composition is present in the cosmetic with anti-aging composition in an amount of 8% by weight.
9. The cosmetic with anti-aging composition according to claim 6, further comprising the following components in weight percent: 5 to 15 percent of humectant, 0.2 to 3 percent of thickener, 5 to 20 percent of fat-liquoring agent, 2.0 to 4.5 percent of emulsifier, 0.5 to 1.0 percent of preservative, 0.03 to 0.1 percent of chelating agent and the balance of deionized water.
10. The cosmetic with anti-aging composition according to claim 9, characterized in that:
the humectant is one or a composition of more than two of glycerol, 1, 3-propylene glycol, 1, 2-pentanediol or 1, 2-hexanediol;
the thickening agent is one or a composition of more than two of xanthan gum, carbomer or acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer;
the fat-imparting agent is one or a composition of more than two of shea butter, caprylic/capric triglyceride, isononyl isononanoate or triglyceride (ethyl hexanoate);
the emulsifier is one or a composition of more than two of cetearyl olive oleate, sorbitan olive oleate or polyglycerol-3 cetyl ether;
the preservative is one or a composition of more than two of glyceryl caprylate, phenoxyethanol and p-hydroxyacetophenone;
the chelating agent is disodium EDTA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211632796.3A CN115844794A (en) | 2022-12-19 | 2022-12-19 | Anti-aging composition, cosmetic containing anti-aging composition and application of cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211632796.3A CN115844794A (en) | 2022-12-19 | 2022-12-19 | Anti-aging composition, cosmetic containing anti-aging composition and application of cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115844794A true CN115844794A (en) | 2023-03-28 |
Family
ID=85674080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211632796.3A Pending CN115844794A (en) | 2022-12-19 | 2022-12-19 | Anti-aging composition, cosmetic containing anti-aging composition and application of cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115844794A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030610A (en) * | 2015-08-18 | 2015-11-11 | 广州栋方生物科技股份有限公司 | Anti-aging composition and preparation method thereof |
| KR20160088848A (en) * | 2016-07-19 | 2016-07-26 | 이정복 | Mineral nutrition composition for cultivating organic mineral sprout and cosmetic composition or functional food comprising thereof |
| CN108096176A (en) * | 2017-11-30 | 2018-06-01 | 广州皓雨投资有限公司 | A kind of botanical composition and its elite dew and preparation method with said composition |
| CN113350230A (en) * | 2021-07-15 | 2021-09-07 | 泉后(广州)生物科技研究院有限公司 | Anti-aging composition and preparation method and application thereof |
| CN114053191A (en) * | 2021-12-30 | 2022-02-18 | 宁波久瑞生物工程有限公司 | Anti-aging composition and preparation method and application thereof |
-
2022
- 2022-12-19 CN CN202211632796.3A patent/CN115844794A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030610A (en) * | 2015-08-18 | 2015-11-11 | 广州栋方生物科技股份有限公司 | Anti-aging composition and preparation method thereof |
| KR20160088848A (en) * | 2016-07-19 | 2016-07-26 | 이정복 | Mineral nutrition composition for cultivating organic mineral sprout and cosmetic composition or functional food comprising thereof |
| CN108096176A (en) * | 2017-11-30 | 2018-06-01 | 广州皓雨投资有限公司 | A kind of botanical composition and its elite dew and preparation method with said composition |
| CN113350230A (en) * | 2021-07-15 | 2021-09-07 | 泉后(广州)生物科技研究院有限公司 | Anti-aging composition and preparation method and application thereof |
| CN114053191A (en) * | 2021-12-30 | 2022-02-18 | 宁波久瑞生物工程有限公司 | Anti-aging composition and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 天娇生物科技（上海）有限公司: "百黛天娇水光皙颜柔肤乳", Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakanHis.html?prodId=20191022140906zy4ei&gb=G> * |
| 广州黛香源生物科技有限公司: "黛香源蜗牛保湿护肤水", Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakanHis.html?prodId=20200901155408e7o2r&gb=G> * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111228208B (en) | Wrinkle-removing composition containing symbiotic bacteria combined fermentation product, wrinkle-removing eye cream and preparation method of wrinkle-removing eye cream | |
| CN109288770B (en) | Anti-aging composition and application thereof | |
| CN111297791A (en) | Anti-aging and repairing skin care composition containing symbiotic bacteria combined fermentation product, essence milk and preparation method and application of essence milk | |
| CN109350579B (en) | Whitening cosmetic additive, whitening skin-refreshing lotion and preparation method thereof | |
| CN113332212A (en) | Whitening composition and preparation method and application thereof | |
| CN114224768A (en) | Repairing and anti-aging composition and preparation method thereof | |
| CN110946784A (en) | Skin care composition with functions of improving skin barrier function and enhancing skin health | |
| CN110721120A (en) | Multifunctional skin care cream and preparation method thereof | |
| CN112315845A (en) | Whitening and freckle removing cream and preparation method thereof | |
| CN112472631A (en) | Multi-effect eye essence and preparation method thereof | |
| CN107375180A (en) | A kind of composite skin care product, facial mask and preparation method thereof | |
| CN114099393A (en) | Composition with tightening and anti-aging effects and preparation method and application thereof | |
| CN113648241A (en) | High-moisture-retention emulsion and preparation method thereof | |
| KR100984163B1 (en) | Humectant cosmetic composition comprising chayote extract and manufacturing method thereof | |
| CN108969407A (en) | Sun-proof essence cream and preparation method thereof | |
| CN111700849A (en) | Whitening composition, cosmetic and application | |
| CN113384510B (en) | Fermented composition with anti-photoaging, relieving and cooling effects and preparation method and application thereof | |
| KR102381645B1 (en) | Cosmetic Composition Comprising Poria cocos Fermentation Extract | |
| CN115844794A (en) | Anti-aging composition, cosmetic containing anti-aging composition and application of cosmetic | |
| CN109998941A (en) | Anti-apolexis composition, anti-ageing face mask and preparation method thereof | |
| CN112972314B (en) | Eye repair composition and preparation method and application thereof | |
| CN112870122B (en) | High-stability nano emulsion with light protection effect and preparation method thereof | |
| CN115414289A (en) | Cordyceps flower cosmetics and preparation method thereof | |
| KR101830860B1 (en) | Cosmetic composition containing Broussonetia extract for anti-aging | |
| CN113749972A (en) | Composition with anti-wrinkle effect and application of composition in cosmetics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |