CN115844754A - Collagen dressing liquid, preparation method thereof and collagen dressing patch - Google Patents
Collagen dressing liquid, preparation method thereof and collagen dressing patch Download PDFInfo
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 35
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Landscapes
- Materials For Medical Uses (AREA)
Abstract
Collagen dressing liquid, a preparation method thereof and a collagen dressing patch relate to the technical field of dressings. The collagen dressing liquid comprises the following components in percentage by mass: collagen protein: 0.05 to 0.3 weight percent; glycerol: 5 to 18 weight percent; carbomer: 0.2 to 0.8 weight percent; preservative: 0.3 to 1 weight percent; and a phosphate buffer. The collagen dressing plaster comprises a basement membrane and a collagen dressing liquid, wherein the collagen dressing liquid soaks the basement membrane. It has good air permeability, is not easy to drip, and has good skin feel.
Description
Technical Field
The application relates to the technical field of dressings, in particular to a collagen dressing liquid, a preparation method thereof and a collagen dressing patch.
Background
After minimally invasive cosmetic surgery, many patients may suffer from various degrees of damage due to the damaged skin barrier, and inflammation, allergy, scars during wound healing, and the like may occur. Patients are therefore often required to use some skin repair products to repair the skin. The dressing is a common product for skin repair, wound repair and the like, and some existing dressing products for skin repair and wound repair usually contain collagen, the collagen has the advantages of high hydrophilicity, low toxicity, weak antigenicity, good biocompatibility, complete biodegradability and the like, and can promote normal growth of epidermal cells and stimulate cell division, so that degradation products of the collagen can be utilized by new cells to synthesize new collagen, and the collagen filled among the new cells can reduce contact inhibition of the growing cells to achieve self-repair.
Some existing collagen dressings usually only pay attention to the efficacy of repairing a wound surface, but do not pay attention to the skin feeling. However, as most dressings are used on the face, improving skin feel can also improve the use satisfaction of the patient.
Disclosure of Invention
The application provides a collagen dressing liquid, a preparation method thereof and a collagen dressing patch, which have good air permeability and are not easy to drip.
The application is realized as follows:
in a first aspect, the present application provides a collagen dressing solution comprising, in mass percent:
collagen protein: 0.05 to 0.3 weight percent;
glycerol: 5 to 18 weight percent;
carbomer: 0.2 to 0.8 weight percent;
preservative: 0.3 to 1 weight percent; and
phosphate buffer.
In a second aspect, the present application provides a method for preparing a collagen dressing solution, comprising: mixing the above components uniformly.
In a third aspect, the present application provides a collagen dressing patch comprising a basement membrane and the collagen dressing solution of the first aspect, wherein the collagen dressing solution impregnates the basement membrane.
The application has at least the following beneficial effects:
the collagen dressing liquid has the collagen content of 0.05-0.3 wt%, and can achieve a good wound repair effect. In addition, glycerine in the dressing liquid has the effect of moisturizing, and has the effect of thickening, and carbomer also has the effect of thickening equally, because the ratio of glycerine in this application and carbomer is suitable for, make the dressing liquid have certain viscosity, under the lighter condition of base film dropping liquid phenomenon, the skin feels more fresh and cool simultaneously, and the gas permeability is better. In addition, the preservative has a certain bacteriostatic action, and when a user uses the preservative, the probability of wound infection caused by bacteria in the environment can be reduced. Because the pH value of the carbomer is 2.5-3.5, the carbomer is strong in acidity, the pH value of the collagen dressing liquid is about 4-6 under the condition that the glycerin, the carbomer and the collagen are kept in a proper proportion under the action of the phosphate buffer, the skin can be maintained in a slightly acidic state, the propagation of facial pathogenic microorganisms is inhibited, and the health of the skin is protected.
Detailed Description
Embodiments of the present application will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present application and should not be construed as limiting the scope of the present application. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The following detailed description is made for the collagen dressing liquid, the preparation method thereof, and the collagen dressing patch in the embodiments of the present application:
in a first aspect, an embodiment of the present application provides a collagen dressing solution, which includes the following components by mass:
collagen protein: 0.05 to 0.3 weight percent;
glycerol: 5 to 18 weight percent;
carbomer: 0.2 to 0.8 weight percent;
preservative: 0.3 to 1 weight percent; and
phosphate buffer.
The collagen has a complete triple-helix structure, can be used for treating superficial scars, promoting the repair of acne surfaces and wound surfaces, has the effects of nourishing skin and moisturizing, and can reduce wrinkles after long-term use.
The collagen content in the collagen dressing liquid is 0.05-0.3 wt%, so that a good wound repair effect can be achieved, scar formation is relieved, and a good moisturizing effect is achieved. Illustratively, the collagen content in the collagen dressing solution is any one of 0.05wt%, 0.08wt%, 0.1wt%, 0.15wt%, 0.20wt%, 0.25wt%, and 0.3wt%, or a value between any two.
Optionally, the collagen is animal-derived collagen. The animal-derived collagen is obtained by extracting animal tissues (such as animal skin, tendon, bone, etc.) as raw materials, wherein the animal can be pig, cattle, sheep, fish, etc. Compared with human-derived recombinant collagen, the animal-derived collagen has the advantages of strong activity and strong repair. It is understood that recombinant collagen may also be selected for collagen.
In some embodiments, the collagen has a molecular weight of 320 to 360KDa, such as a value between any one or any two of 320KDa, 325KDa, 330KDa, 335KDa, 340KDa, 345KDa, 350KDa and 360KDa.
The glycerol in the collagen dressing liquid has the effect of replenishing water and also has a certain thickening effect, so that the collagen dressing liquid has certain viscosity, and the dropping condition of the collagen dressing liquid on the base film can be reduced. If the dropping liquid of the collagen dressing liquid is serious, a large amount of the collagen dressing liquid drops in the using process, so that not only is serious waste caused, but also the amount of the collagen dressing liquid acting on the skin can be reduced, and the effect is greatly weakened.
In addition, the inventor of the present application found in research that the content ratio of glycerin in the collagen dressing liquid seriously affects the skin feel. When the content of glycerin in the collagen dressing liquid is 20wt% or more, the dressing containing the collagen dressing liquid can feel very stuffy and airtight when the dressing is attached to the face. In order to avoid the case of a very tight face, the inventors of the present application considered adjusting the proportion of glycerin to 18wt% or less, but in experiments, it was found that dripping in the collagen dressing solution was somewhat severe when the glycerin content in the collagen dressing solution was less than 20wt% and no carbomer was contained, for example, 15wt% to 18 wt%. Therefore, the inventor considers adding carbomer for compounding, creatively finds that when the content of glycerin in the collagen dressing liquid is 5-18 wt% and the content of carbomer is 0.2-0.8 wt%, the collagen dressing liquid has proper viscosity, and when the dressing containing the collagen dressing liquid is attached to the face for use, the dropping situation is greatly improved, the face is fresh and cool, and the air permeability is good.
Illustratively, the glycerol in the collagen dressing solution is any one of 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt% and 18wt% or a value between any two, in weight percent.
Illustratively, the carbomer in the collagen dressing solution is any one or a value between any two of 0.2wt%, 0.3wt%, 0.4wt%, 0.5wt%, 0.6wt%, 0.7wt%, and 0.8wt%, in weight percent.
In some embodiments, the collagen dressing solution has a mass ratio of collagen to glycerin to carbomer of 0.05 to 0.12:5 to 15:0.3 to 0.8, for example 0.08:5:0.5, 0.08:10:0.5, 0.08:15:0.5.
wherein, the pH value of the carbomer is 2.5-3.5, and the carbomer is strong in acidity. Medical professionals often measure the health of skin as the acid-base value (pH), and consider it healthy if the pH is in the slightly acidic range of 4-6. Under the action of a phosphate buffer solution, the pH value of the collagen dressing liquid is adjusted to be about 4-6 under the condition that the glycerol, the carbomer and the collagen are kept in a proper proportion, so that the skin is maintained in a slightly acidic state, the propagation of facial pathogenic microorganisms is inhibited, and the health of the skin is protected. Compared with the scheme of adjusting the pH value by adding water, the phosphate buffer solution has a buffering effect, so that when carbomer with the pH value of 2.5-3.5 is added, the pH value of the collagen dressing solution is more easily adjusted to 4-6, and the proper amount of the phosphate buffer solution enables the collagen dressing solution to keep a certain viscosity. When carbomer with the pH value of 2.5-3.5 is added, if water is added to adjust the pH value, the pH value is not easy to reach 4-6, and a large amount of water is probably needed to reach the pH value of 4-6, so that the collagen dressing liquid becomes thin, liquid drops easily on the dressing base material, and the content ratio liquid of glycerol, carbomer and collagen in the collagen dressing liquid is difficult to ensure. Moreover, when the collagen dressing liquid contains phosphate buffer solution, the buffering effect can be achieved, and even if some other acidic or alkaline raw materials are additionally added, the pH value of 4-6 cannot be greatly changed, so that the whole collagen dressing liquid is ensured to be between 4 and 6, the proper compounding proportion of the raw materials is more easily realized, and the proper pH value range is ensured.
In addition, the phosphate buffer solution does not damage the biological activity of the collagen, and the reasonable proportion of other components is added, so that the collagen in the collagen dressing liquid provided by the embodiment of the application has good biological activity.
Optionally, the phosphate buffer solution contains mono-and di-hydrogen phosphate salts, e.g., na as mono-hydrogen phosphate 2 HPO 4 And/or K 2 HPO 4 The dihydric phosphate is KH 2 PO 4 And/or NaH 2 PO 4 . Optionally, the phosphate buffer solution further comprises NaCl and/or KCl.
Illustratively, the collagen dressing solution of the present application has a pH of 4 to 6, for example, any one of 4, 4.5, 5, 5.5 and 6 or a value between any two.
In addition, the preservative has a certain bacteriostatic action, and when a user uses the preservative, the probability of wound infection caused by bacteria in the environment can be reduced. Illustratively, the preservative comprises caprylyl hydroximic acid and glyceryl caprylate, wherein the caprylyl hydroximic acid is high in safety, and the glyceryl caprylate is a natural ingredient existing in human breast milk, and the existence of the glyceryl caprylate can obviously improve the overall bacteriostatic ability of the collagen dressing liquid and has certain moisturizing and skin-moistening effects. Alternatively, a preservative may be used
JHD-Plus, which is mild and safe.
Illustratively, the preservative in the collagen dressing solution of the present application is any one of, or a value between any two of, 0.3wt%, 0.4wt%, 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, and 1wt%, in mass percent.
Further, in some embodiments, the collagen dressing also contains sodium hyaluronate and beta-glucan. Illustratively, the collagen dressing solution comprises the following components in weight percent:
collagen protein: 0.05 to 0.3 weight percent;
glycerol: 5 to 18 weight percent;
carbomer: 0.2 to 0.8 weight percent;
preservative: 0.3 to 1 weight percent;
sodium hyaluronate: 0.05 to 2 weight percent;
beta-glucan: 1 to 7 weight percent;
and
phosphate buffer.
The collagen dressing liquid has good moisturizing and water replenishing effects by compounding the sodium hyaluronate and the beta-glucan in a proper proportion and adding the collagen and the glycerol in a proper proportion.
Optionally, the sodium hyaluronate in the collagen dressing solution is any one of, or a value between any two of, 0.05wt%, 0.1wt%, 0.3wt%, 0.5wt%, 0.8wt%, 1.0wt%, 1.2wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.8wt%, and 2wt%, in weight percent.
Optionally, the beta-glucan in the collagen dressing solution is any one of 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, and 7wt%, or a value between any two, in weight percent.
In some embodiments, the sodium hyaluronate comprises sodium hyaluronate with a molecular weight of 7000 to 8000Da, sodium hyaluronate with a molecular weight of 300 to 400KDa, and sodium hyaluronate with a molecular weight of 1.2 to 1.6 MDa. Wherein, the sodium hyaluronate with the molecular weight of 7000-8000 Da can enter the dermis layer through skin absorption, can absorb water to fully accumulate the dermis layer, and recovers the activity of elastic fibers and collagen fibers, so that the skin is smooth and elastic; the sodium hyaluronate with the molecular weight of 300-400 KDa can enter the epidermal layer of the skin, so that the effects of skin tightening, long-term moisture retention and water locking and dehydration prevention are achieved; the sodium hyaluronate with the molecular weight of 1.2-1.6 MDa can absorb water, dilute the outermost skin lipid membrane of the skin to form a uniform and breathable water membrane, and spread the skin lipid membrane, so that large wrinkles formed by accumulation of the skin lipid membrane are effectively solved, and water loss and bacterial infection are prevented. Through the action of sodium hyaluronate with different molecular weights, the effects of well moisturizing can be achieved.
Illustratively, of the sodium hyaluronate having a molecular weight of 7000 to 8000Da, the sodium hyaluronate has a molecular weight of any one of 7000Da, 7200Da, 7400Da, 7500Da, 7521Da, 7600Da, 7800Da, and 8000Da or a value therebetween.
Illustratively, the molecular weight of sodium hyaluronate is 300 to 400KDa, and the molecular weight of sodium hyaluronate is any one of 300KDa, 310KDa, 320KDa, 330KDa, 340KDa, 350KDa, 356KDa, 360KDa, 370KDa, 380KDa, 390KDa and 400KDa, or a value between any two of the above.
Illustratively, sodium hyaluronate having a molecular weight of 1.2 to 1.6MDa has a molecular weight of any one of 1.2MDa, 1.3MDa, 1.4MDa, 1.48MDa, 1.5MDa and 1.6MDa or a value between any two.
Alternatively, the mass ratio of sodium hyaluronate with a molecular weight of 7000 to 8000Da, sodium hyaluronate with a molecular weight of 300 to 400KDa and sodium hyaluronate with a molecular weight of 1.2 to 1.6MDa is 1 to 3, and is 1.
In a second aspect, the present application provides a method for preparing the collagen dressing solution, which comprises the following steps: mixing the above components uniformly.
It should be noted that each component in the preparation method is each component in the final collagen dressing solution, and different components are selected and uniformly mixed according to the setting requirement of the collagen dressing solution.
For example, when the collagen dressing solution includes collagen, glycerin, carbomer, a preservative, and a phosphate buffer, the corresponding preparation steps include: mixing collagen, glycerol, carbomer, antiseptic and phosphate buffer solution.
For example, when the collagen dressing solution includes collagen, glycerin, carbomer, preservative, sodium hyaluronate, beta-glucan, and phosphate buffer, the corresponding preparation steps include: uniformly mixing collagen, glycerol, carbomer, preservative, sodium hyaluronate, beta-glucan and phosphate buffer.
Wherein, in the preparation step of the collagen dressing liquid, the collagen is mixed in the form of collagen sponge. Wherein the collagen sponge may be mixed with the phosphate buffer solution and then mixed with the other components. The collagen sponge is obtained by freeze-drying collagen liquid.
In a third aspect, the present application further provides a collagen dressing patch, which comprises a basement membrane and the collagen dressing solution, wherein the collagen dressing solution soaks the basement membrane.
The inventor of the present application found in research that the basement membrane has a certain effect on the skin feel of the collagen dressing patch, wherein the basement membrane affects the degree of fit and breathability during use. Optionally, the base film is made of viscose. When adopting viscose fiber, not only the degree of compliance when using is better, when using with the collagen dressing liquid collocation of this application moreover, the gas permeability is better. Wherein, the collagen dressing paste also comprises an aluminum foil bag, and the base film and the collagen dressing liquid are both arranged in the aluminum foil bag. The preparation method comprises placing the base film in an aluminum foil bag, filling the collagen dressing liquid into the aluminum foil bag filled with the base film in clean environment, sealing, and refrigerating.
The collagen dressing liquid, the preparation method thereof, and the collagen dressing patch according to the present application will be described in further detail with reference to the following examples.
Example 1
The present embodiment provides a collagen dressing solution, which includes the following components: 0.08 percent of collagen, 5 percent of glycerin, 0.8 percent of carbomer,
JHD-Plus preservative 0.5wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The embodiment also provides a collagen dressing plaster, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of the embodiment 1, wherein the collagen dressing liquid and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing liquid, and the base film is made of viscose fibers.
Example 2
The present embodiment provides a collagen dressing solution, which includes the following components: 0.08 percent of collagen, 10 percent of glycerin, 0.8 percent of carbomer,
JHD-Plus preservative 0.5wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The embodiment also provides a collagen dressing plaster, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of the embodiment 2, wherein the collagen dressing liquid and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing liquid, and the base film is made of viscose fibers.
Example 3
The present embodiment provides a collagen dressing solution, which includes the following components: 0.08 percent of collagen, 15 percent of glycerin, 0.8 percent of carbomer,
JHD-Plus preservative 0.5wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The embodiment also provides a collagen dressing plaster, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of embodiment 3, wherein the collagen dressing liquid and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing liquid, and the base film is made of viscose fibers.
Example 4
The present embodiment provides a collagen dressing solution, which includes the following components: 0.2wt% of collagen, 18wt% of glycerol, 0.2wt% of carbomer,
JHD-Plus preservative 1wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The embodiment also provides a collagen dressing plaster, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of embodiment 4, wherein the collagen dressing liquid and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing liquid, and the base film is made of viscose fibers.
Example 5
The embodiment provides a collagen eggThe white dressing liquid comprises the following components: 0.05wt% of collagen, 5wt% of glycerol, 0.2wt% of carbomer,
JHD-Plus preservative 0.3wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The embodiment also provides a collagen dressing plaster, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of the embodiment 5, wherein the collagen dressing liquid and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing liquid, and the base film is made of viscose fibers.
Example 6
The present embodiment provides a collagen dressing solution, which includes the following components: 0.3wt% of collagen, 8wt% of glycerol, 0.5wt% of carbomer,
JHD-Plus preservative 0.6wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The embodiment also provides a collagen dressing plaster, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of the embodiment 6, wherein the collagen dressing liquid and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing liquid, and the base film is made of viscose fibers.
Example 7
The present embodiment provides a collagen dressing solution, which includes the following components: 0.08 percent of collagen, 10 percent of glycerol, 0.8 percent of carbomer,
JHD-Plus preservative 0.5wt%, sodium hyaluronate 2wt%, beta-glucan 4wt% and the balance phosphate buffer. Wherein the volume of the collagen dressing liquid is 25mL sodium hyaluronate mesochitineSodium hyaluronate with molecular weight of 7521Da, 356KDa and 1.48MDa in a weight ratio of 2. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The present embodiment further provides a collagen dressing patch, which includes an aluminum foil bag, a base film and the collagen dressing solution of embodiment 7, wherein the collagen dressing solution and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing solution, and the base film is made of viscose fibers.
Example 8
The present embodiment provides a collagen dressing solution, which includes the following components: 0.08 percent of collagen, 10 percent of glycerin, 0.4 percent of carbomer,
JHD-Plus preservative 0.5wt%, sodium hyaluronate 1.5wt%, beta-glucan 4wt% and the balance of phosphate buffer. Wherein, the volume of the collagen dressing liquid is 25mL, and the sodium hyaluronate comprises the sodium hyaluronate with the molecular weight of 7521Da, 356KDa and 1.48MDa according to the mass ratio of 1. Wherein the pH of the phosphate buffer is 7.4, and the phosphate buffer is Na 2 HPO 4 、KH 2 PO 4 NaCl and KCl.
The embodiment also provides a collagen dressing plaster, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of the embodiment 8, wherein the collagen dressing liquid and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing liquid, and the base film is made of viscose fibers.
Example 9
The present embodiment provides a collagen dressing solution, which includes the following components: 0.08 percent of collagen, 10 percent of glycerin, 0.4 percent of carbomer,
0.5wt% of JHD-Plus preservative, 1.5wt% of sodium hyaluronate with the molecular weight of 7521Da, 4wt% of beta-glucan and the balance of phosphate buffer. Wherein the pH of the phosphate buffer solution is 7.4, and the phosphate buffer solution is phosphate-bufferedThe flushing liquid is prepared from Na 2 HPO 4 、KH 2 PO 4 NaCl and KCl.
The embodiment further provides a collagen dressing patch, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of embodiment 9, wherein the collagen dressing liquid and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing liquid, and the base film is made of viscose fibers.
Example 10
The present embodiment provides a collagen dressing solution, which includes the following components: 0.08 percent of collagen, 10 percent of glycerin, 0.4 percent of carbomer,
0.5wt% of JHD-Plus preservative, 1.5wt% of sodium hyaluronate with the molecular weight of 356KDa, 4wt% of beta-glucan and the balance of phosphate buffer.
The present embodiment further provides a collagen dressing patch, which includes an aluminum foil bag, a base film, and the collagen dressing solution of embodiment 10, wherein the collagen dressing solution and the base film are both in the aluminum foil bag, the collagen dressing solution soaks the base film, and the base film is made of viscose fibers. Wherein the pH of the phosphate buffer is 7.4, and the phosphate buffer is Na 2 HPO 4 、KH 2 PO 4 NaCl and KCl.
Example 11
The present embodiment provides a collagen dressing solution, which includes the following components: 0.08 percent of collagen, 10 percent of glycerin, 0.4 percent of carbomer,
0.5wt% of JHD-Plus preservative, 1.5wt% of sodium hyaluronate with molecular weight of 1.48MDa, 4wt% of beta-glucan and the balance of phosphate buffer.
The present embodiment further provides a collagen dressing patch, which includes an aluminum foil bag, a base film and the collagen dressing solution of embodiment 11, wherein the collagen dressing solution and the base film are both in the aluminum foil bag, the base film is soaked in the collagen dressing solution, and the base film is made of viscose fibers. Wherein the content of the first and second substances,the pH of the phosphate buffer was 7.4, the phosphate buffer was composed of Na 2 HPO 4 、KH 2 PO 4 NaCl and KCl.
Comparative example 1
The present comparative example provides a collagen dressing comprising the following components: 0.08 percent of collagen, 20 percent of glycerin,
JHD-Plus preservative 0.5wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The comparative example also provides a collagen dressing patch, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of the comparative example 1, wherein the collagen dressing liquid and the base film are both arranged in the aluminum foil bag, the base film is soaked by the collagen dressing liquid, and the base film is made of viscose fibers.
Comparative example 2
The present comparative example provides a collagen dressing comprising the following components: 0.08 percent of collagen, 20 percent of glycerin, 0.4 percent of carbomer,
JHD-Plus preservative 0.5wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The comparative example also provides a collagen dressing patch, which comprises an aluminum foil bag, viscose fibers and the collagen dressing liquid of the comparative example 2, wherein the collagen dressing liquid and the viscose fibers are both in the aluminum foil bag, and the collagen dressing liquid soaks the viscose fibers.
Comparative example 3
The present comparative example provides a collagen dressing comprising the following components: 0.08 percent of collagen, 15 percent of glycerin,
JHD-Plus preservative 0.5wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The comparative example also provides a collagen dressing patch, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of the comparative example 3, wherein the collagen dressing liquid and the base film are both arranged in the aluminum foil bag, the base film is soaked by the collagen dressing liquid, and the base film is made of viscose fibers.
Comparative example 4
The present comparative example provides a collagen dressing comprising the following components: 0.08 percent of collagen, 0.8 percent of carbomer,
JHD-Plus preservative 0.5wt% and the balance phosphate buffer. Wherein the pH of the phosphate buffer is 6.0, and the phosphate buffer is Na 2 HPO 4 And KH 2 PO 4 And (4) forming.
The comparative example also provides a collagen dressing patch, which comprises an aluminum foil bag, a base film and the collagen dressing liquid of the comparative example 4, wherein the collagen dressing liquid and the base film are both arranged in the aluminum foil bag, the collagen dressing liquid soaks the base film, and the base film is made of viscose fibers.
Comparative example 5
This comparative example provides a collagen dressing solution, which differs from example 3 only in that the phosphate buffer of example 3 is replaced with water.
Test examples
(1) Reference is made to YY/T0471.2-2004 contact wound dressing test method part 2: breathable dressing water vapor transmission rate the collagen dressing patches of example 3, and comparative examples 1 and 3 (with the aluminum foil pouch removed) were subjected to the test and the results are reported in table 1.
(2) The viscosities of the collagen dressing solutions of examples 1, 3, 4 and 3 were measured by a rotational viscometer method, which is the third method of the viscosity measurement method of 0633 pharmacopoeia of the people's republic of china (fourth part of 2020 edition), and the results are shown in table 1.
(3) The collagen dressing solutions of examples 1 to 8 and comparative examples 2 to 5 were tested for pH by reference to the pH measurement method of 0631 in the pharmacopoeia of the people's republic of china (fourth part of 2020 edition), and the results are shown in table 1.
(4) 15 persons are randomly selected from the company to perform the use experience on the collagen dressing pastes of the examples 1 to 11 and the comparative examples 1 to 5, before the use, the face is cleaned firstly, the collagen dressing paste (the aluminum foil bag is removed) is applied on the face after the cleaning, after the face is kept for 5 minutes, the collagen dressing paste is taken down and washed by water, and the user records the use experience and feeds back the use experience. The use feeling comprises the degree of the close fit of the collagen dressing, whether the collagen dressing is easy to drip and the degree of refreshment, wherein the degree of the close fit is recorded as 1-4 minutes from poor to good, the dripping condition is recorded as 1-4 minutes from poor to good, and the degree of refreshment is recorded as 1-4 minutes from poor to good. The scores refer to the average scores, and the results are shown in table 1.
TABLE 1 test results for collagen dressing patches
As can be seen from the results of table 1, the scores of the degree of fitness, the dripping condition, and the refreshing degree of examples 1 to 11 were all high, whereas the scores of the refreshing degree were low although the scores of the degree of fitness and the dripping condition were high for comparative examples 1 and 2; the refreshing degree scores of comparative examples 3 to 5 were high, but the degree of fitting and dripping were low. The collagen dressing patch of the embodiment of the application has better fitting degree and refreshing degree, and is not easy to drip.
By comparing the results of comparative example 3 and comparative example 1, it was found that although the scores of the degree of fit and the dropping state of comparative example 1 were higher than that of comparative example 3, the degree of refreshing was lower than that of comparative example 3, and the test results of air permeability also showed that comparative example 1, in which the water vapor transmission amount was smaller than that of comparative example 3, had the air permeability of comparative example 1 smaller than that of comparative example 3, and in addition, the user felt the face stuffy when trying the dressing of comparative example 1. The fact that the collagen dressing liquid is not easy to drip when the content of the glycerol is 20wt% and the carbomer is not contained is shown, but the refreshing degree is reduced, and the face feeling is stuffy. In addition, from the results of comparative example 3 and comparative example 3, it can be found that comparative example 3 has a lower score for the degree of fitting and dripping than example 3 and the viscosity test result is much lower than example 3, which indicates that when the content of glycerin is 15wt% and carbomer is not included, although the refreshing degree is improved, the collagen dressing liquid has a lower viscosity and easily produces dripping. The formula of the embodiment 3 can ensure the refreshing degree, has proper viscosity and is not easy to generate dropping liquid. In addition, as can be seen from the results of the viscosity tests of example 1, example 3, example 4 and comparative example 3, example 1 is different from example 3 only in the content of glycerin, example 1 has a glycerin content of 5wt%, example 3 has a glycerin content of 15%, and the result of the viscosity test of example 1 is not much different from the result of the viscosity test of example 3. Example 3 compared to comparative example 3, comparative example 3 only had less carbomer than example 3, the carbomer content in example 3 was 0.8% by weight, and the results of the viscosity test for the two were significantly different, indicating that the carbomer in the dressing had a greater degree of effect on viscosity than did the glycerol.
In addition, as can be seen from the results in table 1, the collagen dressing solutions of examples 1 to 8 all had pH values between 4 and 6, whereas comparative example 5 had pH values between 4 and 6, had pH 2.8, and had a large deviation from pH =4 to 6. Therefore, the pH value of the collagen dressing liquid can be adjusted to 4-6 by the phosphate buffer under the condition of ensuring that the glycerol, the carbomer and the collagen are kept in a proper proportion. However, it is not easy to adjust the pH to 4 to 6 with water.
The foregoing is illustrative of the present application and is not to be construed as limiting thereof, as numerous modifications and variations will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. The collagen dressing liquid is characterized by comprising the following components in percentage by mass:
collagen protein: 0.05 to 0.3 weight percent;
glycerol: 5 to 18 weight percent;
carbomer: 0.2 to 0.8 weight percent;
preservative: 0.3 to 1 weight percent; and
phosphate buffer.
2. The collagen dressing solution according to claim 1, comprising the following components in weight percent:
collagen protein: 0.05 to 0.3 weight percent;
glycerin: 5 to 18 weight percent;
carbomer: 0.2 to 0.8 weight percent;
preservative: 0.3 to 1 weight percent;
sodium hyaluronate: 0.05 to 2 weight percent;
beta-glucan: 1 to 7 weight percent;
and
phosphate buffer.
3. The collagen dressing solution according to claim 2, wherein the sodium hyaluronate comprises sodium hyaluronate with a molecular weight of 7000 to 8000Da, sodium hyaluronate with a molecular weight of 300 to 400KDa, and sodium hyaluronate with a molecular weight of 1.2 to 1.6 MDa.
4. A collagen dressing according to any one of claims 1 to 3, wherein the mass ratio of said collagen, said glycerol and said carbomer in said collagen dressing is from 0.05 to 0.12:5 to 15:0.3 to 0.8.
5. A collagen dressing according to any of claims 1 to 3, wherein said collagen is animal-derived collagen; optionally, the collagen has a molecular weight of 320 to 360KDa.
6. The collagen dressing solution according to any of claims 1 to 3, wherein the preservative comprises caprylyl hydroxamic acid and glyceryl caprylate.
7. A collagen dressing according to any of claims 1 to 3, wherein the pH of the collagen dressing is between 4 and 6.
8. A method of preparing a collagen dressing according to any one of claims 1 to 7, comprising: mixing the above components uniformly.
9. The method of preparing a collagen dressing according to claim 8, wherein said collagen is mixed in the form of a collagen sponge.
10. A collagen dressing patch, comprising: a basement membrane and a collagen dressing solution according to any one of claims 1 to 7, said collagen dressing solution impregnating said basement membrane.
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| CN104473860A (en) * | 2014-12-23 | 2015-04-01 | 广东粤微食用菌技术有限公司 | Ganodermalucidumcollagen mask and preparation process thereof |
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| CN115400261A (en) * | 2022-09-01 | 2022-11-29 | 江苏扬子江医疗科技股份有限公司 | Recombinant III-type humanized collagen repairing composition and preparation method and application thereof |
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| CN104473860A (en) * | 2014-12-23 | 2015-04-01 | 广东粤微食用菌技术有限公司 | Ganodermalucidumcollagen mask and preparation process thereof |
| CN105983131A (en) * | 2015-02-13 | 2016-10-05 | 陕西巨子生物技术有限公司 | Hydrogel collagen dressing especially suitable for oily skins |
| CN107090458A (en) * | 2017-06-29 | 2017-08-25 | 江苏悦智生物医药有限公司 | Yeast recombined collagen |
| CN113304310A (en) * | 2021-06-04 | 2021-08-27 | 吉林省国大生物工程有限公司 | Medical wet dressing with repairing function and preparation method thereof |
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