CN115843293A - 三环化合物及其制备方法和医药用途 - Google Patents

三环化合物及其制备方法和医药用途 Download PDF

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Publication number
CN115843293A
CN115843293A CN202280005551.XA CN202280005551A CN115843293A CN 115843293 A CN115843293 A CN 115843293A CN 202280005551 A CN202280005551 A CN 202280005551A CN 115843293 A CN115843293 A CN 115843293A
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CN
China
Prior art keywords
cycloalkyl
alkyl
aryl
heterocyclyl
heteroaryl
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Pending
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CN202280005551.XA
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English (en)
Inventor
闫旭
史建新
刘国标
陈士柱
刘原也
陈雷
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National Institutes of Pharmaceutical R&D Co Ltd
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National Institutes of Pharmaceutical R&D Co Ltd
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Publication of CN115843293A publication Critical patent/CN115843293A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles

Abstract

一种三环化合物及其制备方法和医药用途。特别地，涉及通式(I)所示的化合物，含有其的药物组合物，及其制备方法和在用于预防和/或治疗由毒性醛引发的多种疾病中的应用。其中通式(I)中的各基团的定义与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (16)

  1. PCT国内申请，权利要求书已公开。
CN202280005551.XA 2021-06-25 2022-06-14 三环化合物及其制备方法和医药用途 Pending CN115843293A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021107101893 2021-06-25
CN202110710189 2021-06-25
PCT/CN2022/098560 WO2022267930A1 (zh) 2021-06-25 2022-06-14 三环化合物及其制备方法和医药用途

Publications (1)

Publication Number Publication Date
CN115843293A true CN115843293A (zh) 2023-03-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280005551.XA Pending CN115843293A (zh) 2021-06-25 2022-06-14 三环化合物及其制备方法和医药用途

Country Status (3)

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CN (1) CN115843293A (zh)
TW (1) TW202317581A (zh)
WO (1) WO2022267930A1 (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105120866A (zh) * 2013-01-23 2015-12-02 奥尔德拉医疗公司 与毒性醛相关的疾病和治疗
CN108135867A (zh) * 2015-08-21 2018-06-08 奥尔德拉医疗公司 醛结合物和其用途
CN109640983A (zh) * 2016-08-22 2019-04-16 奥尔德拉医疗公司 醛捕获化合物和其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3337486B1 (en) * 2015-08-21 2024-04-03 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
CA3032609A1 (en) * 2016-08-22 2018-03-01 Aldeyra Therapeutics, Inc. Aldehyde trapping compounds and methods of use thereof
EP4086241A4 (en) * 2019-12-30 2024-02-07 The Nat Institutes Of Pharmaceutical R&D Co Ltd TRICYCLIC COMPOUND AND PREPARATION METHOD AND MEDICAL USE THEREOF

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105120866A (zh) * 2013-01-23 2015-12-02 奥尔德拉医疗公司 与毒性醛相关的疾病和治疗
CN108135867A (zh) * 2015-08-21 2018-06-08 奥尔德拉医疗公司 醛结合物和其用途
CN109640983A (zh) * 2016-08-22 2019-04-16 奥尔德拉医疗公司 醛捕获化合物和其用途

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TW202317581A (zh) 2023-05-01
WO2022267930A1 (zh) 2022-12-29

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