CN115779033A - Qi-tonifying and nerve-soothing tablet and preparation method thereof - Google Patents
Qi-tonifying and nerve-soothing tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a qi-tonifying and nerve-soothing tablet and a preparation method thereof, wherein the qi-tonifying and nerve-soothing tablet comprises the following components in parts by weight: 80 to 120 portions of acanthopanax, 130 to 170 portions of fleece-flower root, 80 to 120 portions of tuckahoe, 70 to 110 portions of schisandra fruit, 100 to 140 portions of rehmannia root and 80 to 120 portions of dwarf lilyturf tuber. The preparation method comprises the following steps: pulverizing radix Acanthopanacis Senticosi into fine powder; decocting the rest decoction pieces in water for three times, filtering, mixing filtrates, concentrating the filtrate into soft extract, mixing with radix Acanthopanacis Senticosi fine powder, adding appropriate amount of starch, granulating, mixing, tabletting, and coating with film. The qi-tonifying and mind-tranquilizing tablet prepared by the invention meets the requirements on properties, thin-layer chromatography identification, disintegration time limit and microbial limit, has accurate medicine content, can accurately control the taking dosage, has stable quality, is convenient and quick to take, is convenient to store and transport, and is suitable for symptoms such as weakness, inappetence, soreness and pain of waist and knees, insomnia, dreaminess and the like.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparation processes, and particularly relates to a qi-tonifying and nerve-soothing tablet and a preparation method thereof.
Background
Modern life is actively accelerated, and various stresses are met, according to investigation, the incidence rate of sub-health in people in China is high, and the sub-health state is manifested by fatigue, insomnia, inappetence, immunologic function reduction and the like. Many Chinese patent medicines for tonifying qi and soothing nerves are sold in the market, but the stability of products prepared by the prior art needs to be improved, the medicine content is not accurate enough, and the curative effect cannot be ensured.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the qi-tonifying and nerve-soothing tablet and the preparation method thereof, which are used for treating symptoms such as weakness and hypodynamia, inappetence, soreness of waist and knees, insomnia and dreaminess and the like, and have the advantages of stable quality, accurate medicine content, convenient and quick taking and convenient storage and transportation.
The invention is realized by the following technical scheme:
the qi-tonifying and nerve-soothing tablet comprises the following components in parts by weight: 80 to 120 portions of acanthopanax, 130 to 170 portions of fleece-flower root, 80 to 120 portions of tuckahoe, 70 to 110 portions of schisandra fruit, 100 to 140 portions of rehmannia root and 80 to 120 portions of dwarf lilyturf tuber.
Preferably, the composition comprises the following components in parts by weight: 90 to 110 parts of acanthopanax, 150 parts of fleece-flower root, 100 parts of tuckahoe, 90 parts of schisandra fruit, 120 parts of rehmannia root and 100 parts of dwarf lilyturf tuber.
Preferably, the composition comprises the following components in parts by weight: 100 parts of acanthopanax, 150 parts of fleece-flower root, 100 parts of tuckahoe, 90 parts of schisandra fruit, 120 parts of rehmannia root and 100 parts of dwarf lilyturf tuber.
A preparation method of qi-tonifying and nerve-soothing tablets comprises the following steps:
step 1) weighing raw material acanthopanax root according to parts by weight, and crushing the raw material acanthopanax root into fine powder for later use;
step 2) weighing the rest five-flavor decoction pieces of the tuber fleeceflower root, the tuckahoe, the schisandra chinensis, the rehmannia and the dwarf lilyturf tuber according to the parts by weight, adding water for decocting for three times, wherein the first time lasts for 3-4 hours, the second time lasts for 2-3 hours, and the third time lasts for 2-3 hours, merging the filtrate, and concentrating the filtrate into thick paste;
and 3) uniformly mixing the thick paste prepared in the step 2) and the acanthopanax fine powder prepared in the step 1), adding 50-60 parts of starch according to parts by weight, granulating, totally mixing, tabletting, and coating a film coat to obtain the qi-tonifying and nerve-soothing tablet.
Preferably, the concentration of the concentration in step 2) is 20 to 22 ° Be.
The pharmacology and prescription of the selected medicinal materials are as follows:
acanthopanax root: pungent, slightly bitter and warm. It enters spleen, kidney and heart meridians. Has the effects of replenishing qi to invigorate the spleen, tonifying the kidney, soothing the nerves and the like. Can be used for treating deficiency of spleen-lung qi, asthenia, anorexia, deficiency of both lung and kidney, cough, asthma, soreness of waist and knees, deficiency of heart and spleen, insomnia, and dreaminess.
Polygonum multiflorum: bitter, sweet, astringent and slightly warm. It enters liver, heart and kidney meridians. Has the effects of detoxifying, eliminating carbuncle, preventing malaria, relaxing bowel and the like. Can be used for treating skin sore, carbuncle, skin tuberculosis, skin pruritus, malaria, constipation, and intestinal dryness.
Poria cocos: sweet, bland and neutral. It enters heart, lung, spleen and kidney meridians. Has the effects of promoting diuresis, eliminating dampness, invigorating spleen, calming heart, etc. Can be used for treating edema, oliguria, phlegm retention, dizziness, palpitation, spleen deficiency, anorexia, diarrhea 28601.
And (2) Chinese magnoliavine fruit: sour, sweet, warm. It enters lung, heart and kidney meridians. Has the effects of astringing, arresting discharge, benefiting qi for promoting production of fluid, invigorating kidney, calming heart, etc. Can be used for treating cough, asthma, nocturnal emission, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, thirst due to body fluid consumption, internal heat, diabetes, palpitation, and insomnia.
Rehmannia root: sweet and cold in nature. It enters heart, liver and kidney meridians. Has the effects of clearing heat, cooling blood, nourishing yin, promoting the production of body fluid and the like. Can be used for treating heat entering nutrient-blood, toxic heat generating macula, hematemesis and blood rise, yin injury due to febrile disease, deep-red tongue with dipsosis, constipation due to body fluid consumption, fever due to yin deficiency, bone steaming, overstrain heat, internal heat, and diabetes.
Radix ophiopogonis: sweet, slightly bitter and slightly cold. It enters heart, lung and stomach meridians. Has the effects of nourishing yin, promoting the production of body fluid, moistening lung, clearing away heart-fire and the like. Can be used for treating lung dryness, dry cough, deficiency of yin, throat pain, body fluid deficiency, thirst, internal heat, vexation, insomnia, and constipation.
The invention has the following beneficial effects:
the qi-tonifying and mind-tranquilizing tablet prepared by the invention meets the requirements on properties, thin-layer chromatography identification, disintegration time limit and microbial limit. Each tablet contains echinacoside (C) 17 H 24 O 9 ) The content is 0.08-0.11 mg, the content is accurate, and the dosage can be accurately controlled. After being placed for 36 months, each tablet contains syringin (C) 17 H 24 O 9 ) The total amount of the compound is not less than 0.07mg, and the quality is stable. The adopted dosage form is a film-coated tablet, can prevent the stimulation of the medicine to the gastric mucosa, is convenient and quick to take and storeAnd (5) transporting. Is suitable for asthenia, anorexia, soreness of waist and knees, insomnia, and dreaminess.
Drawings
FIG. 1 is a flow chart of the preparation process of qi-tonifying and tranquilizing tablet.
Detailed Description
The invention is described in further detail below with reference to specific embodiments and with reference to the following drawings.
The reagents and instruments used in the following examples are not indicated by manufacturers, and are all conventional products commercially available.
Example 1
The qi-tonifying and mind-tranquilizing tablet is prepared from the following raw materials in parts by weight: 100g of acanthopanax, 150g of fleece-flower root, 100g of tuckahoe, 90g of schisandra, 120g of rehmannia and 100g of dwarf lilyturf tuber.
The preparation method of the qi-tonifying and mind-tranquilizing tablet is shown in fig. 1, wherein the flow in the background frame in the figure must be completed in a clean area (D level), and the specific steps are as follows:
(1) Pulverizing radix Acanthopanacis Senticosi into fine powder.
(2) Decocting the rest five decoction pieces of Polygoni Multiflori radix, poria, fructus Schisandrae chinensis, rehmanniae radix, and radix Ophiopogonis with water for three times, 4 hr for the first time, 3 hr for the second time, and 3 hr for the third time, mixing filtrates, and concentrating the filtrate to obtain 22 ° Be thick paste.
(3) And (3) uniformly mixing the thick paste and the acanthopanax fine powder, adding 50-60 g of starch, granulating, totally mixing, tabletting and coating a film coat to obtain the qi-tonifying and nerve-soothing tablets.
The product detection of the embodiment:
in the obtained tablet for invigorating qi and tranquilizing mind, each tablet contains syringin (C) 17 H 24 O 9 ) It was calculated to be 0.11mg.
Example 2
The qi-tonifying and nerve-soothing tablet is prepared from the following raw materials in parts by weight: 100g of acanthopanax, 150g of polygonum multiflorum, 100g of poria cocos, 90g of schisandra chinensis, 120g of rehmannia and 100g of radix ophiopogonis.
In the preparation method of the qi-tonifying and mind-tranquilizing tablet, as shown in fig. 1, the flow in the background frame in the drawing must be completed in a clean area (level D), and the specific steps are as follows:
(1) Pulverizing radix Acanthopanacis Senticosi into fine powder.
(2) Decocting the rest five decoction pieces of Polygoni Multiflori radix, poria, fructus Schisandrae chinensis, rehmanniae radix, and radix Ophiopogonis with water for three times (3 hr for the first time, 2 hr for the second time, and 2 hr for the third time), mixing filtrates, and concentrating the filtrate to obtain 22 ° Be thick paste.
(3) Mixing the thick paste and the acanthopanax fine powder uniformly, adding 50-60 g of starch, granulating, totally mixing, tabletting and coating with a film to obtain the qi-tonifying and nerve-calming tablet.
The product detection of the embodiment:
in the obtained tablet for invigorating qi and tranquilizing mind, each tablet contains syringin (C) 17 H 24 O 9 ) It was calculated to be 0.10mg.
Example 3
The qi-tonifying and nerve-soothing tablet is prepared from the following raw materials in parts by weight: 90g of acanthopanax, 150g of polygonum multiflorum, 100g of poria cocos, 90g of schisandra chinensis, 120g of rehmannia and 100g of radix ophiopogonis.
In the preparation method of the qi-tonifying and mind-tranquilizing tablet, as shown in fig. 1, the flow in the background frame in the drawing must be completed in a clean area (level D), and the specific steps are as follows:
(1) Pulverizing radix Acanthopanacis Senticosi into fine powder.
(2) Decocting the rest five decoction pieces of Polygoni Multiflori radix, poria, fructus Schisandrae, rehmanniae radix, and radix Ophiopogonis with water for three times (4 hr for the first time, 3 hr for the second time, and 3 hr for the third time), mixing filtrates, and concentrating the filtrate to obtain 22 ° Be thick paste.
(3) And (3) uniformly mixing the thick paste and the acanthopanax fine powder, adding 50-60 g of starch, granulating, totally mixing, tabletting and coating a film coat to obtain the qi-tonifying and nerve-soothing tablets.
The product detection of the embodiment:
in the obtained tablet for invigorating qi and tranquilizing mind, each tablet contains syringin (C) 17 H 24 O 9 ) It was calculated to be 0.09mg.
Example 4
The qi-tonifying and nerve-soothing tablet is prepared from the following raw materials in parts by weight: 90g of acanthopanax, 150g of polygonum multiflorum, 100g of poria cocos, 90g of schisandra chinensis, 120g of rehmannia and 100g of radix ophiopogonis.
In the preparation method of the qi-tonifying and mind-tranquilizing tablet, as shown in fig. 1, the flow in the background frame in the drawing must be completed in a clean area (level D), and the specific steps are as follows:
(1) Pulverizing radix Acanthopanacis Senticosi into fine powder.
(2) Decocting the rest five decoction pieces of Polygoni Multiflori radix, poria, fructus Schisandrae chinensis, rehmanniae radix, and radix Ophiopogonis with water for three times (4 hr for the first time, 3 hr for the second time, and 3 hr for the third time), mixing filtrates, and concentrating the filtrate to obtain a thick paste with 20 ° Be.
(3) And (3) uniformly mixing the thick paste and the acanthopanax fine powder, adding 50-60 g of starch, granulating, totally mixing, tabletting and coating a film coat to obtain the qi-tonifying and nerve-soothing tablets.
The product detection of the embodiment:
in the obtained tablet for invigorating qi and tranquilizing mind, each tablet contains syringin (C) 17 H 24 O 9 ) It was calculated to be 0.08mg.
Test example 1
The stability tests of the products prepared in examples 1 to 4 were carried out for 0 to 36 months, and the evaluation items were as follows:
1. the characteristics are as follows: film coated tablet, with yellow brown to dark brown core; is bitter in taste.
2. Identifying by thin-layer chromatography:
(1) Fluorescent spots of the same color should appear at the positions corresponding to the color spectrum of the radix Polygoni Multiflori control drug.
(2) Spots of the same color should appear at the positions corresponding to the chromatogram of the deoxyschizandrin reference substance.
3. Disintegration time limit: should disintegrate completely within 1 h.
4. The microbial limit:
(1) Total aerobic bacteria count: it should not exceed 20000cfu/g.
(2) Number of mold and yeast: 200cfu/g should not be exceeded.
(3) Controlling bacteria:
(1) escherichia coli: every 1g should not be detected.
(2) Salmonella: every 10g should not be detected.
5. Content determination: each tablet contains echinacoside (C) 17 H 24 O 9 ) It should not be less than 0.05mg.The results are shown in tables 1-4 below.
Table 1 example 1 product stability test results
Table 2 example 2 product stability test results
Table 3 example 3 product stability test results
Table 4 example 4 product stability test results
As can be seen from tables 1-4, the qi-tonifying and mind-tranquilizing tablet prepared by the invention has the following advantages:
(1) The characters, the thin-layer chromatography identification, the disintegration time limit and the microbial limit all meet the requirements;
(2) Each tablet contains echinacoside (C) 17 H 24 O 9 ) The content is 0.08-0.11 mg, the content is accurate, and the dosage can be accurately controlled;
(3) Placing for 36 months, adding syringin (C) to each tablet 17 H 24 O 9 ) The total amount of the compound is not less than 0.07mg, and the quality is stable.
The above description is only a preferred embodiment of the present invention, and the scope of the present invention is not limited thereto, and any simple modifications or equivalent substitutions of the technical solutions that can be obviously obtained by those skilled in the art within the technical scope of the present invention are within the scope of the present invention.
Claims (5)
1. The qi-tonifying and nerve-soothing tablet is characterized by comprising the following components in parts by weight: 80 to 120 parts of acanthopanax, 130 to 170 parts of fleece-flower root, 80 to 120 parts of tuckahoe, 70 to 110 parts of schisandra fruit, 100 to 140 parts of rehmannia root and 80 to 120 parts of dwarf lilyturf tuber.
2. The qi-tonifying and nerve-soothing tablet as claimed in claim 1, which is characterized by comprising the following components in parts by weight: 90 to 110 parts of acanthopanax, 150 parts of polygonum multiflorum, 100 parts of poria cocos, 90 parts of schisandra chinensis, 120 parts of rehmannia and 100 parts of radix ophiopogonis.
3. The qi-tonifying and nerve-soothing tablet as claimed in claim 2, which is characterized by comprising the following components in parts by weight: 100 parts of acanthopanax, 150 parts of fleece-flower root, 100 parts of tuckahoe, 90 parts of schisandra fruit, 120 parts of rehmannia root and 100 parts of dwarf lilyturf tuber.
4. The preparation method of qi-tonifying and mind-tranquilizing tablet according to any one of claims 1 to 3, characterized by comprising the following steps:
step 1) weighing raw material acanthopanax root according to parts by weight, and crushing the raw material acanthopanax root into fine powder for later use;
step 2) weighing the rest five-ingredient decoction pieces of the tuber fleeceflower root, the tuckahoe, the schisandra chinensis, the rehmannia and the dwarf lilyturf tuber according to the parts by weight, adding water for decocting for three times, wherein the first time lasts for 3-4 hours, the second time lasts for 2-3 hours and the third time lasts for 2-3 hours, combining the filtrates, and concentrating the filtrate into thick paste;
and 3) uniformly mixing the thick paste prepared in the step 2) and the acanthopanax fine powder prepared in the step 1), adding 50-60 parts of starch according to parts by weight, granulating, totally mixing, tabletting, and coating a film coat to obtain the qi-tonifying and nerve-soothing tablet.
5. The preparation method of qi-tonifying and mind-tranquilizing tablet according to claim 4, wherein the concentration in the step 2) is 20-22 ° Be.
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| CN202211574544.XA CN115779033A (en) | 2022-12-08 | 2022-12-08 | Qi-tonifying and nerve-soothing tablet and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1730062A (en) * | 2005-08-02 | 2006-02-08 | 山东仙河药业有限公司 | Chinese medicinal composition for invigorating spleen, tonifying kidney, relieving metal stress and its preparation process |
| CN101612306A (en) * | 2009-07-15 | 2009-12-30 | 天圣制药集团股份有限公司 | A kind of Chinese medicine composition that improves immunity and relieving fatigue and preparation method thereof |
| CN103028036A (en) * | 2011-12-06 | 2013-04-10 | 西安泰科迈医药科技有限公司 | Capsule for improving sleep and preparation method thereof |
-
2022
- 2022-12-08 CN CN202211574544.XA patent/CN115779033A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1730062A (en) * | 2005-08-02 | 2006-02-08 | 山东仙河药业有限公司 | Chinese medicinal composition for invigorating spleen, tonifying kidney, relieving metal stress and its preparation process |
| CN101612306A (en) * | 2009-07-15 | 2009-12-30 | 天圣制药集团股份有限公司 | A kind of Chinese medicine composition that improves immunity and relieving fatigue and preparation method thereof |
| CN103028036A (en) * | 2011-12-06 | 2013-04-10 | 西安泰科迈医药科技有限公司 | Capsule for improving sleep and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 张志亮;侯梦霞;曹冬梅;袁宇;: "百乐眠胶囊佐治慢性肺源性心脏病并发早期肺性脑病患者疗效观察", 中国医院药学杂志, no. 22 * |
| 李作田;: "复方五加参丸治疗神经衰弱100例疗效分析", 黑龙江中医药, no. 04, pages 310 * |
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