CN115607479A

CN115607479A - Moisturizing composition and moisturizing liquid for skin

Info

Publication number: CN115607479A
Application number: CN202211388582.6A
Authority: CN
Inventors: 田勇; 马玉新; 杨佳乐; 姚松利; 戴玉莹; 丁志强; 朱椰琳; 王文艳; 沈洁; 袁菊懋
Original assignee: Shanghai Zhenchen Cosmetics Co Ltd
Current assignee: Shanghai Zhenchen Cosmetics Co Ltd
Priority date: 2022-11-08
Filing date: 2022-11-08
Publication date: 2023-01-17

Abstract

The application discloses a moisturizing composition and a moisturizing liquid for skin, wherein the moisturizing composition comprises the following components in parts by weight: 10 parts of tetradecyl aminobutyroylvalerian amidobutyric urea trifluoroacetate, 0.2-2000 parts of schizophyllan; 0.2-1000 parts of trehalose; 0.02-500 parts of monosaccharide, disaccharide, polysaccharide or combination thereof with the number average molecular weight of 180-600000 for cosmetics; dihydroxypropyl arginine hydrochloride, 0.02-500 parts. The three substances can quickly permeate into the skin on the surface of the skin under the combined action and are identified and combined by receptors on skin tissue cells and immune cells, and the skin is not easy to wash away by water, so that instant moisturizing and long-acting moisturizing are realized.

Description

Moisturizing composition and moisturizing liquid for skin

Technical Field

The application belongs to the technical field of daily cosmetics, and particularly relates to a moisturizing composition and a moisturizing liquid for skin.

Background

Skin, which is located on the surface of the human body, has the function of preventing the loss of body components such as water in the body, and is also an essential barrier. The moisture content of the skin is about 70% in the dermis layer, and decreases as the skin layer approaches, and 10 to 20% of the moisture is retained in the horny layer of the epidermis. The epidermis layer of the skin has a skin barrier function to prevent evaporation of water in the body and to prevent excessive invasion of external substances into the body. In the case of dry skin, the decrease in cohesion between corneocytes or the loss of skin water due to the abnormality of the lipid membrane components of the stratum corneum may not be prevented.

Most of the existing moisturizing cosmetics only adopt different moisturizing agents, so that moisture stays on skin, and the moisturizing effect is poor.

Disclosure of Invention

In view of this, the present application provides a moisturizing composition and a moisturizing liquid for skin, which aim to solve the problem that skin moisture which is often in contact with water is easily lost.

In a first aspect, the present application provides a moisturizing composition for skin, comprising the following components in parts by weight:

tetradecyl aminobutyroylvalerian amidobutyric acid urea trifluoroacetate, 10 parts,

0.2-2000 parts of schizophyllan;

0.2-1000 parts of trehalose;

0.02-500 parts of monosaccharide, disaccharide, polysaccharide or combination thereof with the number average molecular weight of 180-600000 for cosmetics;

dihydroxypropyl arginine hydrochloride, 0.02-500 parts.

According to an embodiment of one aspect of the present application, the moisturizing composition comprises the following components in parts by weight:

schizophyllan, 2-50 parts;

2-50 parts of trehalose;

2-550 parts of monosaccharide, disaccharide, polysaccharide or combination thereof with the number average molecular weight of 180-400000 for cosmetics;

dihydroxypropyl arginine hydrochloride, 2-50 parts.

schizophyllan, 5-20 parts;

5-20 parts of trehalose;

5-20 parts of monosaccharide, disaccharide, polysaccharide or a combination thereof with the number average molecular weight of 180-200000 for cosmetics;

dihydroxypropyl arginine hydrochloride, 5-20 parts.

In a second aspect, the present application provides a moisturizer for skin, comprising, in mass percent:

tetradecyl aminobutyryl valinamide butyric urea trifluoroacetate, 0.1-5%,

0.1% -20% of schizophyllan;

0.1% -10% of trehalose;

0.01% -5% of cosmetic monosaccharide, disaccharide, polysaccharide or their combination with number average molecular weight of 180-600000;

dihydroxypropyl arginine hydrochloride, 0.01% -5%;

0-10% of at least one of glycerol, butanediol, 1, 3-propanediol, 1, 2-pentanediol, caprylyl glycol and sodium hyaluronate;

45 to 99.5 percent of solvent.

According to an embodiment of one aspect of the present application, the moisturizing liquid comprises, in mass percent:

tetradecyl amino butyryl valinamide butyric urea trifluoroacetate, 0.1-5%,

schizophyllan, 5% -10%;

5% -10% of trehalose;

2% -5% of cosmetic monosaccharide, disaccharide, polysaccharide or their combination with number average molecular weight of 180-400000;

dihydroxypropyl arginine hydrochloride, 2% -5%;

4-10% of at least one of glycerol, butanediol, 1, 3-propanediol, 1, 2-pentanediol, caprylyl glycol and sodium hyaluronate;

45 to 99.5 percent of solvent.

tetradecyl amino butyryl valinamide butyric urea trifluoroacetate, 6-9%,

schizophyllan, 6% -9%;

3% -4% of trehalose;

3% -4% of cosmetic monosaccharide, disaccharide, polysaccharide or their combination with number average molecular weight of 180-200000;

dihydroxypropyl arginine hydrochloride, 3% -4%;

5-8% of at least one of glycerol, butanediol, 1, 3-propanediol, 1, 2-pentanediol, caprylyl glycol and sodium hyaluronate;

45 to 99.5 percent of solvent.

According to an embodiment of one aspect of the application, the solvent is selected from an aqueous dispersant, an oily dispersant or a combination thereof.

According to an embodiment of one aspect of the present application, the aqueous dispersant comprises at least one of deionized water, plant extract flower water, aloe water, yeast fermentation broth.

According to an embodiment of one aspect of the present application, the oily dispersant is selected from isododecane, isohexadecane, cyclopentadecylmethicone, dimethicone, hydrogenated dimethicone, modified dimethicone, cyclopentasiloxane, C12-C15 alkyl benzoate, or a combination thereof.

According to an embodiment of one aspect of the present application, the aqueous dispersant includes a dispersant further comprising at least one of a thickener, a neutralizer and a preservative.

According to an embodiment of one aspect of the application, the thickener is selected from carbomers, acrylic polymers cross-linked with C10-C30 alkanol acrylates, xanthan gum or combinations thereof.

According to an embodiment of one aspect of the application, the neutralizing agent is selected from sodium hydroxide, potassium hydroxide or a combination thereof.

According to an embodiment of one aspect of the application, the preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, p-anisic acid, caprylyl glycol, ethylhexyl glycerol, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or a combination thereof.

Compared with the prior art, the application has at least the following beneficial effects:

the moisturizing composition for the skin, provided by the application, comprises 0.2-2000 parts by weight of schizophyllan, 0.2-1000 parts by weight of trehalose and 0.02-500 parts by weight of monosaccharide, disaccharide, polysaccharide or a combination thereof for cosmetics with the number average molecular weight of 180-600000, wherein the three substances can rapidly permeate into the skin on the surface of the skin and are identified and combined by receptors on skin histiocytes and immunocytes, and are not easy to wash away by water, so that instant moisturizing and long-acting moisturizing are realized; the tetradecyl amino butyryl valinamide butyrate urea trifluoroacetate 10 parts by weight and dihydroxypropyl arginine hydrochloride 0.02-500 parts by weight jointly act to penetrate into the skin, so that the endogenous hyaluronic acid or the derivative thereof is promoted to be generated, and the water content of the skin is fundamentally improved; the substances act together to solve the problem that the skin is easy to dry, especially the skin which is often contacted with water or the skin which is often washed by hands is easy to lose moisture.

Detailed Description

In order to make the application purpose, technical solution and beneficial technical effects of the present application clearer, the present application is further described in detail with reference to the following embodiments. It should be understood that the embodiments described in this specification are only for the purpose of explaining the present application and are not intended to limit the present application.

For the sake of brevity, only some numerical ranges are explicitly disclosed herein. However, any lower limit may be combined with any upper limit to form ranges not explicitly recited; and any lower limit may be combined with any other lower limit to form a range not explicitly recited, and similarly any upper limit may be combined with any other upper limit to form a range not explicitly recited. Also, although not explicitly recited, each point or individual value between endpoints of a range is encompassed within the range. Thus, each point or individual value can form a range not explicitly recited as its own lower or upper limit in combination with any other point or individual value or in combination with other lower or upper limits.

In the description of the present application, it is to be noted that "more" and "below" are intended to include the present numbers, and "more" of "one or more" means two or more, unless otherwise specified.

The above summary of the present application is not intended to describe each disclosed embodiment or every implementation of the present application. The following description more particularly exemplifies illustrative embodiments. At various points throughout this application, guidance is provided through a list of embodiments that can be used in various combinations. In each instance, the list is merely a representative group and should not be construed as exhaustive.

The skin is roughly divided into three layers: the epidermis, dermis and subcutaneous fat, act primarily as physical barriers. The stratum corneum in the epidermis inhibits the loss of water and electrolytes to the exterior, thereby preventing the skin from drying out and providing an environment for the normal biochemical metabolism of the skin.

When the moisture content of the keratinocyte layer is equal to or less than 10%, the skin becomes dry, cracked and rough; and moisture is difficult to keep in the skin.

In order to improve the phenomenon that the skin is easily dehydrated, the loss of oil and moisture may be provided to the skin by using the moisturizing composition for cosmetics. In the conventional art, research on cosmetics for providing oil and moisture to the skin is active, and most of the cosmetics are combined by using different humectants, so that the combined moisture stays on the surface layer of the skin, thereby achieving a moisturizing effect. The moisturizing effect of the skin surface layer is greatly reduced after the skin surface layer is washed by water, and the skin surface layer can keep not dry by repeatedly using the product for people who wash hands frequently. And after the skin is stopped, the skin is still dry due to the dry external environment, and the problem of how to keep the skin wet is not solved.

Conventionally, there are also moisturizing substances added with occlusion properties such as vaseline, mineral oil or other oils, but these substances retain water on the outer surface and upper layer of the stratum corneum in a chemically attractive manner, thereby increasing the total water content of the skin. Moisturizing materials of the occlusive nature described above do not provide good sensory feel when applied to the skin, often resulting in a sticky and tacky feel. The skin care product coated surface layer has high water content, and the cutin layer bottom or the position below the cutin layer has low water content, so that the phenomenon of external wetting and internal drying is caused. None of the above methods addresses the problem of deep skin moisturization.

In view of this, the inventors have studied to provide a moisturizing composition gently applied to the skin, which is used to solve the above problems.

Moisturizing composition for skin

In one aspect, the present embodiments provide a moisturizing composition for skin, comprising the following components in parts by weight:

0.2-2000 parts of schizophyllan;

0.2-1000 parts of trehalose;

dihydroxypropyl arginine hydrochloride, 0.02-500 parts.

According to the embodiment of the application, the tetradecyl aminobutyroylvalerian amidobutyric acid urea trifluoroacetate is used in the moisturizing composition, can stimulate the organism to synthesize collagen in a large batch, and simultaneously promote the synthesis of hyaluronic acid, thereby promoting the water retention of connective tissues to enable the skin to be more moisturized and elastic. The myristylaminobutyroylvalinamidobutyric acid urea trifluoroacetate and the dihydroxypropyl arginine hydrochloride jointly promote the generation of endogenous hyaluronic acid. The endogenously produced hyaluronic acid can reconstruct extracellular space of keratinocyte in epidermis, so that the exchange of nutrients is smoother, the function of a ligand for signal transmission is exerted, and the skin is promoted to be healthier, more compact and more moist.

According to the embodiment of the application, dihydroxypropyl arginine hydrochloride is also called dihydroxypropyl arginine HCl, and the moisturizing composition used for the application is safe and has a moisturizing effect; promoting the generation of endogenous hyaluronic acid together with tetradecyl aminobutyroylvalinamide butyrate trifluoroacetate

According to the embodiment of the application, schizophyllan is used for the moisturizing composition of the application, is safe, has a moisturizing effect, and also has the effects of resisting inflammation and enhancing immunity. The schizophyllan and other components act together to further effectively repair the sunburned skin, improve the effects of moisturizing and resisting wrinkles on the skin and ensure that the skin is tender and plump. The schizophyllan component is suitable for 8 types of skin, such as dry skin, wrinkled skin, tight skin, tolerant skin, sensitive skin, non-pigmented skin, pigmented skin and oily skin, and has moisturizing and anti-inflammatory effects. The schizophyllan and the myristyl amino butyryl valinamide butyrate urea trifluoroacetate act together, can rapidly permeate into the skin on the surface of the skin and are recognized and combined by receptors on skin tissue cells and immune cells, the generation of endogenous hyaluronic acid is promoted together, and the water content of the skin is fundamentally improved.

According to the embodiment of the application, the trehalose has the effects of moisturizing, improving the environment adaptation capability of the skin, resisting radiation, stabilizing oxide polyphenol and resisting skin aging; the trehalose can replace the water in cells during severe dehydration, can complement with endogenously generated hyaluronic acid, can keep tissues, skin and cosmetics fresh all the time, and can also achieve the intelligent moisturizing effect. More importantly, there is an interaction between trehalose and endogenous hyaluronic acid in the inner layer of the skin, and it is probably due to the interaction between-OH of trehalose and phospholipid PO ^2- The trehalose and the like are not easy to elute due to interaction, and the effect of long-acting moisture retention is achieved. Thoroughly solves the problem that people who frequently wash hands cannot keep the skin moisture for a long time.

According to an embodiment of the present application, the cosmetic monosaccharide, disaccharide, polysaccharide, or combination thereof having a number average molecular weight of 180 to 600000 has a polar functional group that can form a hydrogen bond, and the polar functional group includes a hydroxyl group and may further include a carboxyl group. Polar functional groups such as hydroxyl and the like can interact with endogenous hyaluronic acid in the inner layer of the skin, are not easy to elute, and achieve the effect of long-acting moisture retention. The saccharides having a number average molecular weight of 180 to 600000 are more likely to interact with endogenous hyaluronic acid, thereby achieving the purpose of being less likely to elute.

Through the research of the inventor, 0.2-2000 parts by weight of schizophyllan, 0.2-1000 parts by weight of trehalose and 0.02-500 parts by weight of monosaccharide, disaccharide, polysaccharide or combination thereof for cosmetics with number average molecular weight of 180-600000 act together to form the moisturizing composition without stimulation or low irritation, and the substances can rapidly permeate into the skin on the surface of the skin to be identified and combined by receptors on skin tissue cells and immune cells and are not easy to wash away by water; on the other hand, instantaneous moisturizing and long-acting moisturizing can be achieved together according to the action of different components, and then the moisturizing composition is comfortable to touch, does not stick greasy and achieves the effect of moisturizing from the deep layer of skin; after a period of use, the moisture content of the skin can be maintained at a relatively high level even when the user deactivates the moisturizing composition of the present application.

The moisturizing composition for the skin can be used for people who frequently wash hands or people who frequently contact water, and solves the problem of dry skin.

In some embodiments, the moisturizing composition comprises the following components in parts by weight:

schizophyllan, 2-50 parts;

2-50 parts of trehalose;

dihydroxypropyl arginine hydrochloride, 2-50 parts.

schizophyllan, 5-20 parts;

5-20 parts of trehalose;

dihydroxypropyl arginine hydrochloride, 5-20 parts.

According to the embodiment of the application, the moisturizing composition can further improve the moisturizing effect on the deep layer of the skin; the binding force of the moisturizing composition and related components in the skin is enhanced, and long-acting moisturizing is realized.

tetradecyl amino butyryl valinamide butyric urea trifluoroacetate, 0.1-5%,

0.1% -20% of schizophyllan;

0.1% -10% of trehalose;

dihydroxypropyl arginine hydrochloride, 0.01% -5%;

45 to 99.5 percent of solvent.

According to the embodiment of the present application, at least one of glycerin, butylene glycol, 1, 3-propanediol, 1, 2-pentanediol, caprylyl glycol, and sodium hyaluronate has superior moisturizing properties. When the substance in the mass range is used in the bag, moisture can be supplemented into skin, the moisture content of the skin surface is increased, and the effects of moisturizing are further achieved. Alternatively, it may be of plant origin.

According to the embodiment of the application, the moisturizing liquid is a non-irritant or low-irritation moisturizing composition, and the substances can quickly permeate into the skin on the surface of the skin to be identified and combined by receptors on skin tissue cells and immune cells and are not easy to wash away by water under the combined action; on the other hand, instantaneous moisturizing and long-acting moisturizing can be achieved together according to the action of different components, and secondly, the moisturizing composition disclosed by the application is comfortable to touch, does not stick to grease, and achieves the effect of moisturizing from the deep layer of skin; after a period of use, the moisture content of the skin can be maintained at a relatively high level even when the user deactivates the moisturizing composition of the present application.

In some embodiments, the moisturizing liquid comprises, in mass percent:

tetradecyl amino butyryl valinamide butyric urea trifluoroacetate, 0.1-5%,

schizophyllan, 5% -10%;

5% -10% of trehalose;

dihydroxypropyl arginine hydrochloride, 2% -5%;

45 to 99.5 percent of solvent.

In some embodiments, the moisturizing liquid comprises, in mass percent:

tetradecyl amino butyryl valinamide butyric urea trifluoroacetate, 6-9%,

schizophyllan, 6% -9%;

3% -4% of trehalose;

dihydroxypropyl arginine hydrochloride, 3% -4%;

45 to 99.5 percent of solvent.

In some embodiments, the solvent is selected from an aqueous dispersant, an oily dispersant, or a combination thereof. The moisturizing composition can be used in water-soluble media and oil-soluble media, is high in compatibility, and has a more common use scene.

In some embodiments, the aqueous dispersant comprises at least one of deionized water, plant extract flower water, aloe water, yeast fermentation broth.

According to embodiments of the present disclosure, at least one of deionized water, plant extract flower water, aloe water, yeast fermentation broth may act as a solvent to dissolve the moisturizing composition therein. For example, the plant flower water can be lavender flower water, rose flower water, bitter orange flower water, verbena flower water, vegetarian flower water, or combinations thereof. For example, the lavender flower water is a lavender flower water distillate, is a colorless and transparent clear liquid, is a 100% saturated hydrolat separated from fresh lavender petals in the process of refining the lavender oil, contains a plurality of water-soluble components such as tannin, protein and plant sugar, and has an anti-oxidation effect on part of the water-soluble components, so that the skin care effect of the moisturizer can be correspondingly improved.

In some embodiments, the oily dispersant is selected from isododecane, isohexadecane, cyclopentadimethylsiloxane, polydimethylsiloxane, hydrogenated polydimethylsiloxane, modified polydimethylsiloxane, cyclopentasiloxane, C12-C15 alkyl benzoate, or a combination thereof.

According to the examples of the present application, the oily dispersant contributes to the moisture retention, safety, moisturizing property, fluidity and homogeneity of the skin moisturizing composition, and ensures the moisturizing effect thereof. Among them, polydimethylsiloxane can improve the penetration effect and the non-greasy skin feeling. The oily dispersant can also be polyglycerol derivative or white oil.

In some embodiments, the aqueous dispersant includes a dispersant further comprising at least one of a thickening agent, a neutralizing agent, and a preservative.

In some embodiments, the thickening agent is selected from carbomers, acrylic polymers crosslinked with C10-C30 alkanol acrylate, xanthan gum, or combinations thereof.

According to the examples of the present application, the above thickener plays an important role in thickening, stability and rheology of a moisturizing composition for skin; by using thickeners in different weight ratios, the moisturizing composition for skin can be in a liquid state, a paste state, or a gel state to suit different scenes. The application adopts the thickening agent with proper proportion, so that the moisturizing liquid has good consistency, and excellent spreadability and ductility. In some embodiments, the moisturizer further comprises 0.1 percent to 8 percent of a thickener by mass percent.

In some embodiments, the neutralizing agent is selected from sodium hydroxide, potassium hydroxide, or a combination thereof. By adding the neutralizing agent, the pH of the moisturizing composition for skin can be controlled to be more suitable for the skin of different users. In some embodiments, the moisturizer further comprises 0.1 to 5 percent by mass of a neutralizing agent.

In some embodiments, the preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, p-anisic acid, caprylyl glycol, ethylhexyl glycerin, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or combinations thereof. The preservative is well compatible with other substances, and the shelf life of the moisturizing liquid for skin can be prolonged by adding the preservative. In some embodiments, the moisturizer further comprises 0.1 to 5 percent by mass of a thickener, preservative.

In some embodiments, the moisturizing composition further comprises an additional penetration enhancing substance selected from the group consisting of lecithin, hydrogenated lecithin, chitosan, hydroxyethyl chitosan, carboxymethyl chitosan, hydroxypropyl chitosan, cyclodextrin, maltodextrin, gum arabic, or combinations thereof. The chitosan may be chitosan. The penetration promoting substance can promote skin absorption and application, and achieve better penetration promoting and moisturizing effects.

The application also provides application of the moisturizing composition in a skin care product, preferably the skin care product comprises an aqueous type skin care product, a gel type skin care product, an emulsion type skin care product, an essence type skin care product or a cream type skin care product.

The water-type skin care product comprises: moisturizing composition liquid, whitening mask, etc.; the gel-type skin care product comprises: moisturizing compositions, jelly-like sleep masks, and the like; the emulsion type skin care product comprises: emulsions and the like; the cream type skin care product includes: creams and the like. Can also be used in cosmetic products.

The present invention also provides a method for preparing a moisturizing composition according to the present invention, comprising the step of mixing the components of the moisturizing composition.

The invention also provides a preparation method of the moisturizing liquid, which comprises the following steps:

providing the components of the moisturizing solution of the second aspect,

the components are uniformly mixed to obtain a mixture, namely the moisturizing liquid.

Optionally, the mixture is passed through a high pressure microfluidizer to obtain a moisturizer.

Examples

The present disclosure is more particularly described in the following examples that are intended as illustrative only, since various modifications and changes within the scope of the present disclosure will be apparent to those skilled in the art. All parts, percentages, and ratios reported in the following examples are on a weight basis, all reagents used in the examples are commercially available or synthesized according to conventional methods and can be used directly without further treatment, and the equipment used in the examples is commercially available, unless otherwise specified.

Examples and comparative examples

The embodiment of the application provides a moisturizing liquid for skin, which comprises the following components in percentage by mass:

tetradecyl amino butyryl valinamide butyric urea trifluoroacetate, 0.1-5%,

0.1% -20% of schizophyllan;

0.1% -10% of trehalose;

dihydroxypropyl arginine hydrochloride, 0.01% -5%;

45 to 99.5 percent of solvent.

The moisturizing composition for skin is prepared as follows: the above components are mixed and prepared into a uniform state. The specific composition of each component is shown in table 1.

The contents of the components of the comparative examples are shown in Table 2, and the preparation method is the same as that of the examples.

Table 1 examples the components of the moisturizers and their amounts.

Table 2 components and their contents of the moisturizing solutions of the comparative examples.

Test section

1) Chick embryo chorioallantoic Membrane test results

Basic principle of the test: the chorioallantoic membrane (CAM) is a respiratory membrane that surrounds the chick embryo. Because the surface blood vessels of the chick embryo allantoic membrane are rich and can be regarded as a complete organism, the test utilizes the characteristics of complete, clear and transparent blood vessel system of the chick embryo chorioallantoic membrane in the middle period of incubation, a certain amount of test object is directly contacted with the chick embryo allantoic membrane, the change of chorioallantoic membrane toxicity effect indexes (such as bleeding, blood coagulation and blood vessel dissolution) is observed after the test object acts for a specified time, the score is given, and the mathematical average value is calculated for evaluating the eye irritation of the test object.

Test method and procedure

1. CAM preparation

Removing eggshell from the top of the air chamber of 9-day-old chick embryo, adding proper amount of normal saline on the egg membrane, pouring out, carefully peeling off the egg membrane by using medical elbow tweezers to expose the allantoic membrane, and observing the integrity of the allantoic membrane.

2. Positive/negative control

Before the main test, a negative control test and a positive control test are performed. Negative control adopts 0.9% sodium chloride solution; the positive control was selected from the substance capable of producing a severe reaction, 1% SDS, 0.1mol/L sodium hydroxide.

3. Observing the test object and calculating the score

In the case of the official test, 6 chick embryos per test subject were used. Sucking or weighing 0.3ml or 0.3g sample on allantoic membrane, covering the surface as much as possible, exposing for 5min (if the sample is solid, after contacting for 3min, washing with physiological saline, and then pouring out), immediately observing the variation degree of each toxic effect under a stereoscopic microscope, observing and recording the time or degree from the test start to the appearance of each hemorrhage, blood coagulation and vascular thawing, and performing irritation scoring by using a time evaluation method and an end point scoring method.

And, the score range is set to 0-10, 10 is the safest, and 0 is the most irritating.

And (3) detecting results: the safety of the example group and the comparative example group was 10 points, and neither stimulation was observed.

2) Patch test

1. Experimental method

1.1 test materials

The test substance: moisturizing compositions of examples 1-7

Negative control: blank control

A spot tester: shanghai sanitation Material works Ltd. +140801

Testing an instrument: quantitative piston gun (Microman M100+ GILSON LCO 5239), single channel liquid-moving machine (Transferpette +08N 33275)

2. Test method

Subject: a total of 30 subjects; the minimum age is 21 years, the maximum age is 35 years; mean age 29 ± 5.4 year old volunteers met the enrollment criteria.

The spot-sticking test method comprises the following steps: selecting a qualified spot tester, placing 0.020-0.025g (essence) of a tested object in the spot tester by a closed spot patch test method, externally applying a medical adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions respectively at 0.5, 24 and 48 hours after the spot patch is removed, and recording the result according to the skin reaction grading standard in the technical Specification for cosmetic safety.

3. Basis of examination

The fifth part of the technical Specification for cosmetic safety, namely the classification standard of adverse skin reactions in a human skin closed patch test, shows the detection results in Table 5.

The specific reaction degree is classified into grades:

1. negative reaction;

2. and (3) suspicious reaction: only faint erythema;

3. weak positive reaction (erythema reaction): erythema, infiltration, edema, and possibly papules;

4. strong positive reaction (herpes reaction): erythema, infiltration, edema, papules, herpes, reactions that may be beyond the test area;

5. very strong positive reaction (fusogenic herpes reaction): erythema, severe infiltration, edema, fusional herpes, and response beyond the test area.

TABLE 3 closed Patch test results for human skin for moisturizing compositions of examples 1-8

From the above conclusion of table 3 it can be seen that: the result of the human skin closed patch test shows that 0 of 30 persons has positive reaction, and the tested substance does not cause adverse skin reaction to the batch of tested persons according to the technical Specification for cosmetic safety. Indicating that the moisturizing composition prepared using the moisturizing composition of the present invention has less irritation.

2) Moisturizing effect after elution

Performed on the skin of the forearms of men and women at 25 degrees celsius at 50% relative humidity. The forearm test site was cleaned with tap water (pH 6-9 and at ambient temperature above) for 15 seconds and dried with a paper towel (gentle wipe). After 20 minutes, a baseline skin moisture meter reading was taken, the sample compositions of the examples and comparative examples (25 uL) were dispensed onto the test site (12 cm 2), and spread using a non-absorbent finger cot.

10 minutes after application, skin moisture meter readings were taken at five different sites of each panelist test site (deep skin moisturization was measured using a skin tissue moisture meter from Delfin company, model finland Delfin, mousteemeter SC compact, mousteemeter d).

Experiments were conducted using the moisturizing solutions of examples and comparative examples. For a total of 32 subjects, the above moisturizers were applied to the forearms for 4 weeks.

The water retention was measured for 48 hours using a skin stratum corneum water tester from bio Systems Ltd, england, model E100, and the same left hand side transition site was measured before, after and after 48 hours after the use of the moisturizer product described above, using the value of epsilon representing the overall average dielectric constant of the skin. The more the measured value is increased, the higher the moisture retention effect at 48 hours.

The external moisture retention was measured using a skin stratum corneum moisture tester of bio Systems Ltd, england, model E100, and the same forearm site was measured before, after and four weeks after the use of the above product, and the measurement value used is the value of ∈ indicating the overall average dielectric constant of the skin. The more the measured value increases, the more the moisturizing degree improves.

The degree of deep skin moisturization was measured using a skin tissue moisture content measuring instrument of Delfin moluremeter SC compact model, finland Delfin corporation, moluremeter d, and the same forearm site was measured before using the above product and after four weeks after use, and the measured values were au (arbitraryunit) using the unit of skin moisture content in proportion to the total amount of moisture in the tissue. The more the measurement increases, the more the deep skin moisturizes.

The measurements were performed periodically with the epidermal water loss measurements, and the same forearm sites were measured before and after four weeks of use of the product. The measurement value is the value of g/square meter/h used for measuring the moisture release degree of the skin epidermis, and the decrease of the measurement value is the better the moisture loss of the epidermis is. The results of the human suitability test are shown in table 4 below.

TABLE 4

As can be seen by comparing the moisturizing effects of the examples and the comparative examples, the moisturizing property of the epidermis of the examples was increased as measured using a skin moisture tester. In contrast, the sequence of moisturizing effect is example 8> example 1> example 7> example 2 and example 6; the overall effect of the example is greater than that of the comparative example. This shows that the moisturizing compositions of the examples work together unexpectedly synergistically.

4) Freshness and stickiness sensing test

Test objects: moisturizing liquids of examples and comparative examples

70 volunteers are collected, randomly divided into 7 groups, 10 people in each group are allowed to use the moisturizing liquids of the examples and the comparative examples respectively, the product use refreshing comfort of the volunteers is counted after the moisturizing liquids are applied, the counting is 0-10 min, the higher the score is, the better the refreshing comfort is, and the final comfort experience value is counted. After the paint is applied, the sticky feeling of the volunteers is counted, and the paint is divided into the following parts according to the intensity in sequence: no sticky feeling, light sticky feeling, ordinary sticky feeling, obvious sticky feeling and strong sticky feeling.

Table 5 use of cooling comfort and use of sensory test results.

Sample(s)	Fresh comfort score	Sticky feeling
			Example 1	9.5	Has no sticky feeling
Example 2	9.0	Has no sticky feeling
			Comparative example 1	8.5	Less sticky feeling
Comparative example 2	8.0	Obvious sticky feeling
			Comparative example 3	8.5	Less sticky feeling
Comparative example 4	8.0	General greasy feeling
			Comparative example 5	7.5	Obvious sticky feeling

As can be seen from the above table, according to the use and rating of the moisturizing liquids of the examples and the comparative examples by volunteers, the moisturizing liquids of the examples have higher refreshing comfort and stronger comparative examples; meanwhile, 0.2 to 2000 parts by weight of schizophyllan, 0.2 to 1000 parts by weight of trehalose and 0.02 to 500 parts by weight of monosaccharide, disaccharide, polysaccharide or combination thereof for cosmetics with the number average molecular weight of 180 to 600000, the three substances can quickly permeate into the skin on the surface of the skin to be identified and combined by receptors on skin tissue cells and immune cells under the combined action of the three substances, are not easy to wash away by water, and realize instant moisturizing and long-acting moisturizing; can also improve the sticky feeling of skin caused by the addition of occlusion properties such as vaseline or mineral oil, and improve refreshing feeling.

The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily think of various equivalent modifications or substitutions within the technical scope of the present application, and these modifications or substitutions should be covered within the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A moisturizing composition for skin comprises the following components in parts by weight:

0.2-2000 parts of schizophyllan;

0.2-1000 parts of trehalose;

dihydroxypropyl arginine hydrochloride, 0.02-500 parts.

2. The moisturizing composition for skin of claim 1, comprising the following components in parts by weight:

schizophyllan, 2-50 parts;

2-50 parts of trehalose;

dihydroxypropyl arginine hydrochloride, 2-50 parts.

3. A moisturizing composition for the skin according to claim 2, characterized by comprising, in parts by weight:

tetradecylaminobutylamidobutanamide urea trifluoroacetate, 10 parts,

schizophyllan 5-20 weight portions;

5-20 parts of trehalose;

dihydroxypropyl arginine hydrochloride, 5-20 parts.

4. A moisturizing liquid for skin comprises the following components in percentage by mass:

tetradecyl aminobutyryl valinamide butyric urea trifluoroacetate, 0.1-5%,

0.1% -20% of schizophyllan;

0.1% -10% of trehalose;

dihydroxypropyl arginine hydrochloride, 0.01% -5%;

45 to 99.5 percent of solvent.

5. The moisturizing solution as claimed in claim 4, comprising in mass percent:

tetradecyl amino butyryl valinamide butyric urea trifluoroacetate, 0.1-5%,

schizophyllan, 5% -10%;

5% -10% of trehalose;

dihydroxypropyl arginine hydrochloride, 2% -5%;

45 to 99.5 percent of solvent.

6. The moisturizing solution according to claim 5, comprising, in mass percent:

tetradecyl aminobutyryl valinamide butyric urea trifluoroacetate, 6-9%,

schizophyllan, 6% -9%;

3% -4% of trehalose;

3-4% of cosmetic monosaccharide, disaccharide, polysaccharide or combination thereof with number average molecular weight of 180-200000;

dihydroxypropyl arginine hydrochloride, 3% -4%;

45 to 99.5 percent of solvent.

7. A moisturizing liquid according to any of claims 4 to 6, characterized in that the solvent is selected from aqueous dispersants, oily dispersants or a combination thereof.

8. A moisturizing liquid according to claim 7,

the aqueous dispersant comprises at least one of deionized water, plant flower water, aloe water and yeast fermentation liquor;

the oily dispersant is selected from isododecane, isohexadecane, cyclopentadecyldimethyl siloxane, polydimethylsiloxane, hydrogenated polydimethylsiloxane, modified polydimethylsiloxane, cyclopentasiloxane, C12-C15 alkyl benzoate or a combination thereof.

9. The moisturizing solution of claim 7, wherein the aqueous dispersant further comprises at least one of a thickener, a neutralizer, and a preservative.

10. The moisturizer of claim 9, wherein the thickener is selected from the group consisting of carbomers, acrylic polymers crosslinked with C10-C30 alkanol acrylates, xanthan gum, or combinations thereof;

the neutralizing agent is selected from sodium hydroxide, potassium hydroxide or a combination thereof;

the antiseptic is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, p-anisic acid, caprylyl glycol, ethylhexylglycerin, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or a combination thereof.