CN115554211A

CN115554211A - Dendrobium stem shampoo

Info

Publication number: CN115554211A
Application number: CN202110743942.9A
Authority: CN
Inventors: 李利生; 王燕
Original assignee: Zunyi Medical University
Current assignee: Zunyi Medical University
Priority date: 2021-07-01
Filing date: 2021-07-01
Publication date: 2023-01-03

Abstract

The invention provides dendrobe shampoo which comprises dendrobe total alkaloids and pharmaceutically acceptable auxiliary materials. According to the invention, the optimal formula of the dendrobium total alkaloid shampoo is finally screened out through an orthogonal test, and various performance tests and indexes of the finished shampoo meet the relevant standards of the shampoo, so that the dendrobium total alkaloid can be used as an additive component for preparing the shampoo.

Description

Dendrobium stem shampoo

Technical Field

The invention relates to the technical field of natural medicines, and particularly relates to dendrobe shampoo and a preparation method thereof.

Background

The shampoo, also known as shampoo, cream shampoo, shampoo or shampoo, is the most widely used daily product at present. Is mainly used for removing and cleaning various human body secreted grease and sweat scales attached to the scalp and hair, cells which are already shed from the scalp, foreign dust, microorganisms, residues of hair styling products such as hair spray, bad smell and the like so as to keep the hair and the scalp clean and keep the whole hair beautiful. The basic ingredients for the shampoo in the market at present mainly comprise a main surfactant, a cosurfactant, a thickening agent, a carding agent, a pearling agent and the like, and the shampoo after comprehensive proportioning has the following properties: the hair cleaning agent has moderate cleaning capability, can remove deposits and scalp on hair, and can not cause hair dryness due to excessive degreasing; rich, fine and stable foam can be generated in the hair washing process; the use is convenient, and the cleaning is easy; the performance is mild, the irritation to eyes and scalp is low, the detergent is nontoxic, and the detergent can be used safely; the dry and wet combing property is good, and the hair is glossy; the deposition of the various conditioners and additives is modest and does not cause excessive deposition upon repeated use over an extended period of time.

The shampoo without the silicone oil is deeply understood in the market, is found to be more favored, a part of the basic formula of the shampoo nowadays contains the silicone oil, the shampoo containing the silicone oil can enable hair to become smoother, but the shampoo with the silicone oil can be increasingly deposited on scalp after long-term use, and often causes the problems of itching, scurf, scalp stimulation and the like, and the shampoo without the silicone oil can not only bring mild and refreshing use feeling, but also carefully care the scalp, and can solve the problems of itching, scurf and the like. In addition, hair washing and caring products with traditional Chinese medicine active ingredients added into shampoo are widely favored, the traditional Chinese medicines added into the shampoo as traditional Chinese medicine ingredients on the market at present mainly comprise 5 traditional Chinese medicines, namely Chinese arborvitae twig, tuber fleeceflower root, ginger, ginseng and Chinese angelica, the five traditional Chinese medicines mainly supplement qi and blood, and are supplemented with functions of clearing heat and cooling blood, promoting blood circulation to remove blood stasis, relieving exterior syndrome and the like on the basis of the traditional Chinese medicines.

The research is mainly based on the market demand on shampoo products containing traditional Chinese medicine active ingredients, and has important social and economic significance for developing green and efficient shampoo without adverse reaction and containing traditional Chinese medicine ingredients. In addition, the dendrobium nobile is used as a main raw material for preparing the shampoo, so that the medicinal material source of dendrobium nobile in red water city of Guizhou province can be fully and comprehensively utilized, and the research and development of dendrobium nobile high-added-value products are further realized.

In order to determine that the dendrobium total alkaloids have functionality as additives, the formula of the dendrobium total alkaloids shampoo is screened, basic performance tests and comparisons of related shampoos are performed, and whether the dendrobium total alkaloids can be prepared into the shampoo or not can be basically determined according to results of the performance tests without influencing the basic performances of the shampoo.

Disclosure of Invention

Based on the above, the invention provides the dendrobe shampoo which comprises dendrobe total alkaloids and pharmaceutically acceptable auxiliary materials.

Furthermore, the dendrobium nobile lindl is dendrobium nobile lindl.

Further, the dendrobe shampoo does not contain silicone oil.

Further, the adjuvant comprises one or more selected from the group consisting of: ammonium laureth sulfate, ammonium lauryl sulfate and cocamidopropyl theine.

Furthermore, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine is 1 (1-60) to 1-60 (1-60).

Furthermore, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine is 1 (1-60) to 1-30 (1-40).

Furthermore, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine is 1 (20-60) to 10-30 to 10-40.

Furthermore, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine is 1 (20-60): (15-30): (15-40).

Further, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine ranges from 1.

Furthermore, the weight percentage range of the dendrobium total alkaloids in the dendrobium shampoo is 0.2-1%.

Furthermore, the weight percentage range of the dendrobium total alkaloids in the dendrobium shampoo is 0.2-0.4%.

Further, the weight percentage of the total dendrobium alkaloid in the dendrobium shampoo is about 0.4%.

Furthermore, the weight percentage range of the ammonium laureth sulfate in the dendrobium nobile shampoo is 5-20%.

Furthermore, the weight percentage range of the ammonium laureth sulfate in the dendrobium shampoo is 8-12%.

Further, the ammonium laureth sulfate is present in the dendrobium shampoo in an amount ranging from about 8% by weight.

Further, the weight percentage range of the ammonium lauryl sulfate in the dendrobium nobile shampoo is 2-10%.

Further, the weight percentage range of the ammonium lauryl sulfate in the dendrobium nobile shampoo is 4-6%.

Further, the ammonium lauryl sulfate ranges from about 6% by weight in the dendrobe shampoo.

Further, the weight percentage range of the cocamidopropyl rubine in the dendrobium stem shampoo is 2-10%.

Further, the weight percentage range of the cocamidopropyl rubine in the dendrobium stem shampoo is 4-8%.

Further, the weight percentage of the cocamidopropyl theophylline in the dendrobium stem shampoo ranges from about 6%.

Further, the adjuvant further comprises one or more selected from the group consisting of: coconut oil diethanolamide, guar gum hydroxypropyl trimethyl ammonium chloride, EDTA disodium, polyquaternium-7, pyridone ethanolamine salt, pearly luster slurry, panthenol, glycerol, sodium lauroyl glutamate, sodium lauroyl sarcosinate, sodium chloride, citric acid, polyethylene glycol 6000 distearate, DMDM hydantoin and carbazone.

Further, the dendrobe shampoo further comprises an aloe extract.

According to another aspect of the invention, a method for preparing dendrobium stem shampoo is provided, and the method comprises the step of mixing dendrobium stem total alkaloids and a proper amount of pharmaceutically acceptable auxiliary materials.

Further, the method comprises the steps of:

(1) Dissolving polyethylene glycol 6000 distearate in water to obtain a first solution;

(2) Dissolving cationic guar hydroxypropyl trimonium chloride in an aqueous solution containing coconut oil diethanolamide to obtain a second solution;

(3) Adding disodium EDTA, sodium chloride and citric acid into water, dissolving, adding ammonium laureth sulfate and ammonium lauryl sulfate, and mixing to obtain a third solution;

(4) Mixing the third solution with the second solution to obtain a fourth solution;

(5) Mixing the fourth solution with the dendrobium total alkaloids to obtain a fifth solution;

(6) Mixing cocamidopropyl rubusphylline, pyridone ethanolamine salt and coconut oil diethanolamide to obtain a sixth solution;

(7) Mixing the fifth solution with the sixth solution to obtain a seventh solution;

(8) Mixing the seventh solution with pearly luster slurry and glycerol to obtain an eighth solution;

(9) Dissolving polyquaternium-7 and panthenol in water to obtain a ninth solution;

(10) Mixing the ninth solution with the eighth solution to obtain a tenth solution;

(11) Mixing the tenth solution with aloe extract, sodium lauroyl glutamate and sodium lauroyl sarcosinate to obtain an eleventh solution;

(12) Mixing the eleventh solution with the first solution to obtain a twelfth solution; and

(13) Mixing the twelfth solution with the kaempferol and the DMDM hydantoin to obtain the dendrobe shampoo.

Further, a stirring step is further included in steps (2), (4), (5), (7), (8), (10), (11), (12) and (13).

Further, the stirring time is 5 to 30min.

Further, in step (3), the ammonium laureth sulfate and/or the ammonium lauryl sulfate are dissolved by ultrasonic dissolution or by a homogenizing mixer.

Further, in the step (3), the ammonium laureth sulfate and/or the ammonium lauryl sulfate are dissolved by ultrasonic waves.

In the research, the dendrobium nobile medicinal material produced in red water in Guizhou province is adopted to prepare the shampoo, the optimal formula of the dendrobium nobile shampoo is finally screened out through an orthogonal test, and various performance tests and indexes of the finished shampoo meet the relevant standards of the shampoo, so that the dendrobium nobile total alkaloids can be used as the additive components for preparing the shampoo.

When the content of herba Dendrobii alkaloid is 0.4%, ammonium laureth sulfate (AESA-70) is 8%, and ammonium lauryl sulfate (K) ₁₂ A-70) is 6%, and cocoamidopropyl rubusine (CAB-35) is 6%, the dendrobium nobile shampoo can obtain better stability and more appropriate pH value. Compared with water, the performance of the water-based paint is superior to that of water in all aspects; compared with shampoo with basic formula and shampoo with brand A, the foaming property and the cleaning property are slightly inferior, the surface tension and the viscosity are equivalent, the flexibility and the combing property are better, and the internal control index meets the standard.

When the addition amount of the dendrobium nobile lindl alkaloid is 0.4%, the shampoo has no difference with the brand A shampoo in the aspects of foaming property, surface tension, cleaning property, viscosity, flexibility, combing property and other properties, and the dendrobium nobile lindl shampoo can prove that the preparation scheme of the dendrobium nobile lindl shampoo is feasible.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without departing from the scope of the present invention as claimed.

FIG. 1 is a graph comparing the foaming properties of different samples at 0min. Wherein: p <0.1, x: p <0.01, x: p <0.0001. The different samples in fig. 1 are water, base formula shampoo, dendrobium stem shampoo and brand a shampoo, from left to right.

FIG. 2 is a graph comparing the foaming properties of different samples at 5 minutes. Wherein: p <0.01,.: p <0.001. The different samples in fig. 2 are water, base formula shampoo, dendrobium stem shampoo and brand a shampoo, from left to right, respectively.

Fig. 3 is a comparison of surface tension for different samples. The different samples in fig. 3 are water, base formula shampoo, dendrobium stem shampoo and brand a shampoo, respectively.

Figure 4 is a comparison of the cleanliness of different samples. Wherein: p <0.1, x: p <0.0001. The different samples in fig. 4 are water, base formula shampoo, dendrobium stem shampoo and brand a shampoo, from left to right, respectively.

FIG. 5 is a graph comparing the viscosities of different samples. Wherein: p <0.0001. The different samples in fig. 5 are water, base formula shampoo, dendrobium stem hair spray and brand a shampoo from left to right.

FIG. 6 is a graph comparing the compliance of different samples. Wherein: p <0.0001. The different samples in fig. 6 are water, base formula shampoo, dendrobium stem shampoo and brand a shampoo, from left to right, respectively.

FIG. 7 is a graph comparing dry combing performance of different samples. Wherein: p <0.001, P <0.0001. The different samples in fig. 7 are water, base formula shampoo, dendrobium stem shampoo and brand a shampoo, from left to right, respectively.

FIG. 8 is a comparison of wet combing performance of different samples. Wherein: p <0.0001. The different samples in fig. 8 are water, base formula shampoo, dendrobium stem shampoo and brand a shampoo, from left to right, respectively.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict. The present invention will be described in detail with reference to examples.

The invention is described in further detail below with reference to specific examples, which are not to be construed as limiting the scope of the invention as claimed.

As described in the background section, the existing shampoo is increasingly deposited on the scalp after long-term use, and often causes the problems of itching of the head, scurf and irritation of the scalp, obvious side effects, complex process and higher cost. In order to solve the problems, the invention provides dendrobe shampoo which comprises dendrobe total alkaloids and pharmaceutically acceptable auxiliary materials.

In the present invention, the term "pharmaceutically acceptable" means that the molecular entities and compositions do not produce any adverse or allergic or any other unwanted reaction when administered to a human. As used herein, the term "pharmaceutically acceptable excipient" includes any diluent, adjuvant, such as preservatives, fillers, disintegrants, wetting agents, emulsifiers, dispersing agents, antibacterial agents, or antifungal agents. The use of such media or carriers is well known to those skilled in the art.

In a preferred embodiment, the dendrobium stem is dendrobium stem.

The Dendrobium nobile lindl belongs to Dendrobium plants in the family of orchidaceae, is a famous and precious Chinese medicinal material in China, is sweet and slightly cold in nature, enters stomach and kidney meridians, and has the effects of tonifying stomach, promoting fluid production, nourishing yin and clearing heat. Meanwhile, dendrobium nobile is the first source of medicinal dendrobium nobile in Chinese pharmacopoeia (2015), which has pharmacological effects of resisting tumor, mutation, aging, oxidation, platelet aggregation, blood sugar and the like. The dendrobium nobile lindl alkaloids are found to be characteristic components in modern researches, and the pharmacological actions of the dendrobium nobile lindl alkaloids mainly comprise: (1) the antioxidant activity is measured in research by 1, 1-Diphenyl-2-trinitrophenylhydrazine free radical (1, 1-Diphenyl-2-piperidinyloxy benzyl radial 2, 2-Diphenyl-1- (2, 4, 6-trinitrophenyl) hydrazinyl, DPPH), 2 '-diazo-bis-3-ethylbenzothiazoline-6-sulfonic acid scavenging ability (2, 2' -azino-bis (3-ethylbenziothiazoline-6-sulfonic acid) of the dendrobium nobile total alkaloids extracted by different methods and potassium ferricyanide reducing ability, the capacity of the dendrobium nobile ethyl acetate extract for scavenging free radicals is found to be stronger than that of the ethanol extract, the ethyl acetate extract has relatively stronger antioxidant activity, the added components are mainly dissolved in ethyl acetate with stronger polarity, the dendrobium nobile total alkaloids have certain antioxidant activity, 2, the dendrobium nobile total alkaloids can be tested by bacteriostatic action of the dendrobium nobile total alkaloids, the anti-aging effect can be shown by the anti-aging effect of bacteriostasis, the anti-aging effect of the dendrobium nobile extract can be improved by the anti-nociceptive action of the alkaloid, the anti-aging effect of the dendrobium nobile extract can be found by the tests of the alkaline alkaloid, the dendrobium nobile extract, the anti-3-nociceptive effect of improving the anti-nociceptive effect of the dendrobium nobile.

In a preferred embodiment, the dendrobe shampoo does not comprise silicone oil.

Wherein, the silicone oil-free shampoo is suitable for flat collapse and oily hair quality, and the hair is fluffy after washing and has obvious hair quantity; meanwhile, the silicon-free shampoo is not easy to be allergic and is more suitable for sensitive scalp people.

In a preferred embodiment, the excipient comprises one or more selected from the group consisting of: ammonium laureth sulfate, ammonium lauryl sulfate and cocamidopropyl theine.

The ammonium laureth sulfate is a white or light yellow gel paste or a colorless or light yellow liquid, has wide application, is often used in daily chemical industry, textile, leather and other industries, is often used for washing, wetting, diffusing and the like, and is often used as a cleaning agent, a remover and a laundry detergent, and is used for preparing shampoo and laundry paste.

Among them, ammonium lauryl sulfate is a commonly used surfactant in soap and shampoo. The surfactant reduces the surface tension of the water, thereby allowing the water to penetrate into the fibers. The solubility of ammonium lauryl sulfate in water is higher than that of sodium lauryl sulfate.

The cocoamidopropyl sweet theophylline is a zwitterionic surfactant, has excellent stability under acidic and alkaline conditions, respectively presents positive and negative ions, is often used together with anionic, cationic and nonionic surfactants, and has good compatibility. The detergent has the advantages of small irritation, easy water dissolution, acid and alkali stability, more foams, strong detergency, excellent thickening property, softness, bactericidal property, antistatic property and hard water resistance. Can obviously improve the softness, conditioning and low-temperature stability of washing products.

In a preferred embodiment, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl rubusine ranges from 1 (1-60) to 1-60.

In a preferred embodiment, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine ranges from 1 (1-60) to (1-30) to (1-40).

In a preferred embodiment, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl rubusine ranges from 1 (20-60) to (10-30) to (10-40).

In order to obtain better stability and pH value of the dendrobium shampoo, in a preferred embodiment, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine ranges from 1 (20-60) to (15-30) to (15-40).

In order to obtain better stability and ph value of the dendrobium nobile shampoo, in a preferred embodiment, the weight ratio between the dendrobium nobile total alkaloid, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine ranges from 1.

In a preferred embodiment, the dendrobium total alkaloids in the dendrobium shampoo have a weight percentage range of 0.2% -1%.

In a preferred embodiment, the dendrobium total alkaloids in the dendrobium shampoo have a weight percentage range of 0.2% -0.4%.

In a preferred embodiment, the dendrobium total alkaloids are in the dendrobium shampoo in a weight percentage range of about 0.4%.

The term "about" or "approximately" with respect to a numerical value means ± 5% of the numerical value, but specifically includes the exact numerical value.

In a preferred embodiment, the ammonium laureth sulfate is present in the dendrobium shampoo in an amount ranging from 5% to 20% by weight.

In a preferred embodiment, the ammonium laureth sulfate is present in the dendrobium shampoo in an amount ranging from about 8% to about 12% by weight.

In a preferred embodiment, the ammonium laureth sulfate is present in the dendrobium shampoo in an amount in the range of about 8% by weight.

The term "about" or "approximately" with respect to a numerical value means ± 5% of the numerical value, but explicitly includes the exact numerical value.

In a preferred embodiment, the ammonium lauryl sulfate is present in the dendrobium shampoo in an amount ranging from 2% to 10% by weight.

In a preferred embodiment, the ammonium lauryl sulfate is present in the dendrobium shampoo in an amount ranging from 4% to 6% by weight.

In a preferred embodiment, the ammonium lauryl sulfate ranges from about 6% by weight in the dendrobium stem shampoo.

In a preferred embodiment, the weight percentage of the cocamidopropyl rubusine in the dendrobium stem shampoo is in the range of 2% to 10%.

In a preferred embodiment, the weight percentage of the cocamidopropyl rubusine in the dendrobium stem shampoo ranges from 4% to 8%.

In a preferred embodiment, the weight percentage of the cocamidopropyl sutheophylline in the dendrobium stem shampoo is in the range of about 6%.

In a preferred embodiment, the adjuvant further comprises one or more selected from the group consisting of: coconut oil diethanolamide, guar gum hydroxypropyl trimethyl ammonium chloride, EDTA disodium, polyquaternium-7, pyridone ethanolamine salt, pearly luster slurry, panthenol, glycerol, sodium lauroyl glutamate, sodium lauroyl sarcosinate, sodium chloride, citric acid, polyethylene glycol 6000 distearate, DMDM hydantoin and carbazone. In the practical application process, the auxiliary materials can be replaced by other auxiliary materials which are conventional in the field according to the actual situation.

In a preferred embodiment, the dendrobe shampoo further comprises aloe extract.

In a preferred embodiment, the method comprises the steps of:

(6) Mixing cocamidopropyl betaine, pyridone ethanolamine salt and coconut oil diethanolamide to obtain a sixth solution;

In the practical application process, the auxiliary materials can be replaced by other auxiliary materials which are conventional in the field according to the actual situation.

In a preferred embodiment, a stirring step is further included in steps (2), (4), (5), (7), (8), (10), (11), (12) and (13).

In a preferred embodiment, the stirring time is 5 to 30min.

In a preferred embodiment, in step (3), the ammonium laureth sulfate and/or the ammonium lauryl sulfate are dissolved by ultrasonic dissolution or by a homogenizing mixer.

In a preferred embodiment, in step (3), the ammonium laureth sulfate and/or the ammonium lauryl sulfate are dissolved by sonication.

Wherein, the dissolution of laureth ammonium sulfate and lauryl ammonium sulfate can adopt the supersound to dissolve also can adopt the homogenizer to dissolve, but uses the supersound to dissolve comparatively thoroughly, and laureth ammonium sulfate and lauryl ammonium sulfate can lead to the homogenizer to damage during the homogenizing stirring, can appear the rotor damaged condition.

Examples

1. Materials and methods

1.1 materials

TABLE 1 Experimental instruments List

TABLE 2 list of reagents

1.2 methods

1.2.1 method for preparing dendrobium nobile total alkaloids

Referring to the preparation method in patent application CN201810468060.4, the dendrobium stem coarse powder is taken, added with 90% ethanol with the weight 10 times of that of the coarse powder to be soaked for 12-16 hours, boiled and extracted for 3 times, 2 hours each time, filtered, the filtrate is concentrated into extract, dissolved by hydrochloric acid aqueous solution with the pH value of 3.5, and filtered. Passing the filtrate through cation exchange resin (sodium type), washing with distilled water to colorless, washing with 60-85% ethanol to colorless, washing the column with 25% ammonia water in 80% ethanol after colorless, detecting with 10% silicotungstic acid, and concentrating the washing solution to obtain the final product with high purity (78.3%).

1.2.3, dendrobium nobile Total alkaloid, AESA-70, CAB-35, K ₁₂ Screening for A-70 dosage

Cold-blending shampoo with Munsenhua (process discussion of Munsenhua. Cold-blending shampoo) [ J]Chinese laundry article industry, 2015 (10): 46-52) as basic formula and simultaneously as preventiveThe deposition of silicone oil can be prevented, which can cause the irritation problems of head itch, dandruff, scalp, etc., and the silicone oil in the original formula can be removed. Firstly, pre-dissolving polyethylene glycol 6000 distearate (638) by using 5% of water, and simultaneously pre-dissolving cationic guar hydroxypropyl trimethyl ammonium chloride (C-14S) by using 5% of water and 1% of coconut diethanolamide (6501), wherein stirring is accelerated during dissolving; then sequentially adding EDTA, naCl and citric acid into the rest water, dissolving, adding ammonium laureth sulfate (AESA-70) and ammonium lauryl sulfate (K) ₁₂ A-70) dissolving the two until the two are transparent by using ultrasound; next, adding pre-dispersed guar hydroxypropyl trimethyl ammonium chloride (C-14S), stirring for 5-10 min, adding the dendrobium nobile total alkaloids, and continuing stirring; adding coconut diethanolamide (6501) dissolved in cocamidopropyl betaine (CAB-35) and pyridone ethanolamine (OCT), and stirring for 5-10 min; adding the pearlescent slurry and glycerol, and stirring for 5-10 min; then weighing polyquaternium-7 (M550) and panthenol, pre-dissolving with 5% water, adding into the system, and stirring to be uniform; sequentially adding Aloe extractive solution, sodium lauroyl glutamate (AC-223), and sodium lauroyl sarcosinate (AC-215), and stirring; adding the pre-swelled polyethylene glycol 6000 distearate (638), and stirring for 5-10 min; adding antiseptic Kathon and DMDM hydantoin; finally stirring for 10-30 min and discharging.

Wherein the herba Dendrobii total alkaloids, ammonium laureth sulfate (AESA-70), cocamidopropyl betaine (CAB-35), and ammonium lauryl sulfate (K) ₁₂ The amounts of A-70) were prepared as in Table 3.

A. The proportion of the dendrobium stem total alkaloids is as follows: a. The ₁ ＝0.2，A ₂ ＝0.3，A ₃ ＝0.4

B. Proportioning percentage of ammonium laureth sulfate (AESA-70): b ₁ ＝8，B ₂ ＝10，B ₃ ＝12

C. Ammonium lauryl sulfate (K) ₁₂ A-70) mixing ratio%: c ₁ ＝4，C ₂ ＝5,C ₃ ＝6

D. The mixing ratio of the cocamidopropyl rubusophylline (CAB-35)% is as follows: d ₁ ＝4，D ₂ ＝6，D ₃ ＝8

And finally, carrying out comprehensive scoring by comparing the color, viscosity, pH value and heat resistance of shampoos with different proportions through an L9 orthogonal test to determine the optimal proportion of the dendrobium nobile shampoo.

(1) Color evaluation

Due to individual difference, the color is judged by the same person, and the color of the shampoo is evaluated mainly through visual sense.

(2) Evaluation of viscosity

And measuring the viscosity of the shampoo sample by adopting a rotational viscometer and selecting a proper rotor and rotating speed for three times, and taking an average value.

(3) Evaluation of pH value

Weighing 1 part (accurate to 0.1 g) of sample, adding 10 parts of deionized water, heating to 40 ℃, continuously stirring to be uniform, cooling to room temperature to be used as a solution to be measured, and measuring by using a pH meter.

(4) Evaluation of Heat resistance

Adjusting the temperature of the electric heating constant temperature incubator to 40 +/-1 ℃, placing the shampoo sample in the electric heating constant temperature incubator for 24 hours, taking out the shampoo sample, and observing whether layering exists.

TABLE 3 Dendrobium stem shampoo formula screening table

1.2.4, performance testing

After the dendrobium nobile shampoo with the optimal proportion is determined, a comparison experiment is carried out, and the added dendrobium nobile shampoo and the base formula shampoo (the difference between the base formula shampoo and the dendrobium nobile shampoo is that the dendrobium nobile total alkaloids are lacked, and other components are the same) and brand A (a soft essence nursing series, ginseng nourishing and repairing, aiming at damage problems such as dyeing and scalding, the net content is 750ml, and the number is 91667479) are compared, and the performances of the shampoos are different. The performance test is finished by trusting a third party Chengcheng monitoring and analyzing center (Shandong, qingdao), and the main performance tests comprise: the method comprises the following steps of foam testing, surface tension testing, cleaning testing, viscosity testing, softness testing, carding testing and internal control index testing.

1.2.4.1, foam test

Preheating a constant temperature water bath to 40 +/-1 ℃, opening water circulation, and preheating a Roche foaming tester to 40 +/-1 ℃.2.5 g (equal to net content) of a sample required by the test is weighed, 100mL 1500mg/kg of hard distilled water is used for dissolving (0.0999 g of calcium chloride and 0.148g of magnesium sulfate are sequentially weighed, a small amount of distilled water is used for dissolving in a 1000mL volumetric flask, then the solution is diluted by distilled water until the scales are evenly shaken), the solution is transferred to a 1000mL glass flask, then distilled water is added until the scales reach the scales, the glass flask is placed in a constant-temperature water bath kettle at (40 +/-1) DEG C for continuous heating and aging, and the time is timed for 30min. The inner wall of the graduated tube in the test needs to be washed by the aged test solution, the test solution is injected from the bottom of the graduated tube to a position above a 50mL graduation line, the stopcock of the graduated tube is closed, and the test solution in the tube is discharged after standing for 5min so that the liquid level of the aged reagent reaches the 50mL graduation line. The dropping tube is filled with 200mL of test solution by a suction method, the outlet of the dropping tube is fixed above the graduated tube by using a cross and placed at the position of 900mm at the upper end of the graduated tube, and attention needs to be paid to ensure that the outlet of the dropping tube is positioned in the center of the graduated tube. The dropping tube is opened, when the test solution is exhausted, timing can be started, the average height of the foam in the tube is read (the average height of the foam edge and the foam vertex is taken), and the average height is read again at the end of 5 min. And (4) repeating the test twice by using a new test solution, wherein the inner wall of the graduated tube needs to be washed clean by using the new test solution before each test. Care was taken to ensure that the height of each subsequent drop of sample was the same.

1.2.4.2 surface tension test

(1) Preparing a sample stock solution: accurately weighing 1g of shampoo sample to be measured, dissolving the shampoo sample in a proper amount of water, shaking up, and accurately metering to 100mL.

(2) Preparing a solution to be detected: respectively transferring 25mL, 20mL, 15mL, 10mL, 5mL, 2.5mL, 1mL and 0.5mL of the original preparation solution into a 50mL volumetric flask with constant volume, and marking the volumetric flask as the solution to be tested No. 1#, no. 2#, no. 3#, no. 4#, no. 5#, no. 6#, no. 7# and No. 8 #; respectively transferring 5mL, 2.5mL and 1mL of the solution to be tested from No. 6 to 50mL of constant volume, and marking as No. 9#, no. 10# and No. 11# of the solution to be tested; 5mL and 2.5mL of the solution to be tested No. 9 are respectively transferred and diluted to 50mL, and marked as the solution to be tested No. 12 and No. 13.

(3) The surface tension of each solution to be measured was measured five times, and the average value was taken.

1.2.4.3 cleaning Performance test

Weighing 20g (accurate to 0.001 g) of a shampoo sample to be tested, diluting the shampoo sample to 1000mL by taking 100mL of hard water (1500 mg/kg), and pouring the shampoo sample into a detergency test rinser; taking a JB-03 standard sebum dirt cloth, and cutting the JB-03 standard sebum dirt cloth into a plurality of circular standard sebum dirt cloths with the diameters of 6 cm; randomly taking 5 pieces of round standard sebum dirt cloth, placing the cloth in a detergency test rinser, and simultaneously placing 3 small-size washing balls; controlling the temperature at 40 ℃, rotating at 120r/min, uniformly stirring and washing for 20min, taking out, washing the foam on the dirt washing cloth with clean water, naturally ventilating and drying, respectively and sequentially testing the whiteness values of 5 round standard sebum dirt cloths, and taking an average value. And finally, comparing the whiteness values of the dirty cloth before and after cleaning, and taking the difference value before and after cleaning, wherein the larger the whiteness difference value is, the stronger the cleaning and dirt removing capacity is.

1.2.4.4 viscosity test

The viscosity test was carried out according to 1.2.3 (2).

1.2.4.5 compliance test

(1) Hair bundle pretreatment: firstly, preparing a plurality of hair bundles (the length of the hair bundle is 50cm, the weight is about 20 g), washing and rubbing twice by tap water with the temperature of 40 ℃, and naturally ventilating and drying. 5g of sodium dodecyl sulfate was weighed and dissolved in a 1000mL beaker and heated to 75 ℃. The tresses were then soaked in a beaker and placed in a constant temperature and humidity cabinet at 45 ℃ for two hours. Taking out the hair bundle, gently kneading, washing with tap water, blowing to half dry with a blower at a distance of 20cm from the hair bundle, and naturally airing.

(2) Testing the flexibility of the hair bundle: and (3) smearing 5g of a shampoo sample to be detected on the hair bundle, gently rubbing the hair bundle for two minutes until the shampoo generates rich foam, standing for five minutes, washing the hair bundle with tap water, and naturally ventilating and drying. And then, placing the hair bundle on a friction coefficient tester, testing the friction coefficient of the hair, measuring for three times, and taking an average value, wherein the smaller the numerical value is, the better the flexibility of the hair bundle is, and thus the quality of the shampoo sample is judged.

1.2.4.6 carding Property test

(1) Hair bundle pretreatment: the test was carried out with reference to 1.2.2.5 softness

(2) Tress combing test: weighing 5g of shampoo sample to be detected, smearing the shampoo sample on hair strands, gently rubbing the hair strands for two minutes until the shampoo generates abundant foams, standing for five minutes, and then washing the hair strands clean with tap water. Excess hair moisture was wiped off with a towel until no water was dripping from the hair strands, and after the hair strands were combed with a comb, the wet hair combability was measured with a hair comber. Then, the hair is blown to be half-dry by a blower at a position 20cm away from the hair bundle, combed smoothly by a comb, aired in natural ventilation, and combed by a hair combing instrument.

1.2.4.7 shampoo internal control index test

And carrying out internal control index test on the shampoo to be tested according to GB/T29679-2013.

2. Results

2.1, dendrobium nobile Total alkaloid, AESA-70, CAB-35, K ₁₂ Results of different proportions of A-70

2.1.1 Effect on pH

The pH value of the shampoo in the specified standard is 4.0-8.0, the pH value of human skin is about 6.5, the pH value is the mildest when acting on human epidermis, and the ideal range of the pH value of the shampoo in the experiment is selected to be 6.0-7.0. From Table 4, it can be seen that in the system, when the total alkaloid content of Dendrobium nobile is 0.4%, AESA-70% and K is 8% ₁₂ When the A-70 content is 6% and the CAB-35 content is 6%, the pH value of the system is 6.51.

2.1.2 Effect on viscosity

The viscosity of the shampoo is not specifically regulated in the regulation, the viscosity of the shampoo on the market is different, the viscosity range can be 4000-50000 mPa.s, the high-viscosity shampoo is beneficial to the stability of the product, and the ideal range of the viscosity of the shampoo is selected from 40000-50000 mPa.s in the experiment. As shown in Table 5, when the content of total alkaloids in Dendrobium nobile Lindl is 0.4%, AESA-70%, K ₁₂ When A-70 is 6% and CAB-35 is 6%, the viscosity of the system is 46800 mPa.s, which is in line with the selected range of pH. Wherein A: dendrobium nobile total alkaloids, B: ammonium laureth sulfate (AESA-70), C: baylaurelAmmonium sulfate (K) ₁₂ A-70), D: cocamidopropyl theine (CAB-35).

Table 4 comparison table of pH results of shampoos with different proportions

TABLE 5 comparison of viscosity results for shampoos of different proportions

2.1.3 Effect on color

Table 6 shows that the color depth is determined by the addition amount of the total alkaloids of Dendrobium nobile Lindl, and the color will be slightly darker when the addition amount is larger, and the optimal color is slightly yellow according to the selected range of pH and viscosity. Wherein A: dendrobium nobile total alkaloids, B: ammonium laureth sulfate (AESA-70), C: ammonium lauryl sulfate (K) ₁₂ A-70), D: cocamidopropyl rubusphylline (CAB-35).

TABLE 6 comparison table of color results of shampoos with different proportions

2.1.4 Heat resistance

According to the selected ranges of pH, viscosity and color, as can be seen from Table 7, the samples were placed in an electric oven at 40 ℃ for 24 hours, and no delamination occurred in all samples. Wherein A: dendrobium nobile total alkaloids, B: ammonium laureth sulfate (AESA-70), C: ammonium lauryl sulfate (K) ₁₂ A-70), D: cocamidopropyl theine (CAB-35).

TABLE 7 comparison of heat resistance results of shampoos with different proportions

Orthogonal experiment results show that when the total alkaloids of dendrobium nobile lindl are 0.4%, the AESA is 8%, the K12A is 6% and the CAB is 6%, the product can obtain better stability and pH value, so that the dendrobium nobile lindl-containing shampoo formula shown in table 8 can be obtained:

TABLE 8 Dendrobium stem shampoo formula

2.2 evaluation result of performances of dendrobium stem shampoo

2.2.1 foamability

The results of the foaming property test are shown in fig. 1 and fig. 2. As can be seen from fig. 2 and 3, at 0min and 5min, the foam heights and foam height differences of the dendrobium stem shampoo, the base formula shampoo and the brand a shampoo are much higher than that of water, and the foam heights and foam height differences of the other three samples except water are the brand a shampoo, the base formula shampoo and the dendrobium stem shampoo in sequence from high to low.

2.2.2 surface tension

The results of the surface tension property test are shown in FIG. 3. As can be seen from the figure, in addition to water, the surface tension curves of the dendrobium stem shampoo, the base formula shampoo and the brand a shampoo are gradually reduced, the surface tension difference of the dendrobium stem shampoo and the base formula shampoo is not large, the surface tension of the brand a shampoo is small, but the surface tension difference of the dendrobium stem shampoo, the base formula shampoo and the brand a shampoo is not large.

2.2.3, cleaning Property

The cleaning capacity is represented by testing the whiteness difference of the sebum dirt cloth, and the larger the difference is, the stronger the cleaning capacity is; the smaller the difference, the weaker the cleaning ability is. As can be seen from fig. 4, the cleaning ability of water is the weakest, and the cleaning ability of the dendrobium stem shampoo, the base formula shampoo and the brand a shampoo are sequentially enhanced.

2.2.4, viscosity

As can be seen from fig. 5, the viscosity of water is very low and has almost no value, and there is no difference in the viscosity of the dendrobium stem shampoo, the base formula shampoo and the brand a shampoo.

2.2.5 compliance

The smaller the value of the kinetic friction coefficient, the better the suppleness of the hair after washing, as judged by testing the kinetic friction coefficient of the hair strands after washing with the sample. As can be seen from fig. 6, the coefficient of dynamic friction of water is the greatest, and the coefficients of dynamic friction of the base formula shampoo, the brand a shampoo and the dendrobium stem shampoo are not very different.

2.2.6 combing Property

The results of the dry and wet combing test of water, dendrobium stem shampoo, base formula shampoo, and brand a shampoo are shown in fig. 7 and fig. 8. It can be seen that the dry combing of the four samples is much less than the wet combing; in the aspect of wet combing property, the friction resistance of water is the largest, and the dendrobium stem shampoo is larger than the base formula shampoo and the brand A shampoo and has the smallest value; the friction resistance of water is the largest in dry combing property, and the base formula shampoo is larger than dendrobium stem shampoo and brand A shampoo and is the smallest in brand A shampoo.

2.2.7, hygienic index

The prepared dendrobium nobile shampoo is subjected to a sanitation index test according to GB/T29679-2013, the test result is shown in Table 9, and all sanitation indexes reach standard requirements.

TABLE 9 sanitary index table for Dendrobium stem shampoo

2.2.8, physical and chemical indexes

Physical and chemical index tests are carried out on the prepared dendrobium nobile shampoo according to GB/T29679-2013, and the results are shown in Table 10. Test results show that the dendrobium stem shampoo in the research reaches the standard and reaches the top-grade product.

TABLE 10 physicochemical index Table of Dendrobium stem shampoo

3. Conclusion

Firstly, in the process of screening the shampoo formula, selecting pH, viscosity, heat resistance and color as the consideration conditions of the screened shampoo, obtaining the shampoo with pH of 6.51, viscosity of 46800mPa & s and slightly yellow heat-resistant non-layering color through experiments, wherein the four consideration results of the shampoo all meet the relevant standards. Then, performance comparison experiments of different shampoos are carried out on the basis of further determining that the addition of dendrobium nobile lindl has no great influence on the basic performances of the shampoos.

In terms of foamability, the dendrobium stem shampoo has poor foamability and stability compared with brand A shampoo and base formula shampoo, but the dendrobium stem shampoo still has good stability and foamability in performance.

In the aspect of surface tension, no matter the brand A shampoo, the base formula shampoo or the dendrobium stem shampoo has no obvious difference in surface tension, which indicates that the cleaning capability of the shampoo is not influenced after the dendrobium stem is added.

In the aspect of cleaning performance, compared with the brand A shampoo and the base formula shampoo, the dendrobium stem shampoo added with the dendrobium stem shampoo has reduced dirt-removing power, but the cleaning performance of the dendrobium stem shampoo is not obviously affected, and the aim of cleaning can still be achieved.

In the aspect of viscosity stability, the brand A shampoo, the base formula shampoo and the dendrobium stem shampoo have no difference in viscosity, which shows that the viscosity of the shampoo cannot be affected after the dendrobium stem is added, layering is not easy to occur, and the dendrobium stem shampoo still has good stability.

In the aspect of flexibility, the brand A shampoo, the base formula shampoo and the dendrobium stem shampoo have no difference in the dynamic friction coefficient, and the shampoo still keeps good flexibility after the dendrobium stem is added into the shampoo.

In the aspect of combing property, the wet combing property of the dendrobium nobile shampoo is slightly poor, and the dry combing property is slightly good, which shows that the combing property of the shampoo cannot be obviously affected by adding the dendrobium nobile total alkaloids in the shampoo, and the dendrobium nobile shampoo still has proper hair care and hair moistening effects.

In the research, the total alkaloids in dendrobium nobile lindl produced in red water city of Guizhou province is adopted to prepare the shampoo, the optimal formula of the dendrobium nobile lindl shampoo is finally screened out through an orthogonal test, and various performance tests and indexes of the finished shampoo meet the relevant standards of the shampoo, so that the dendrobium nobile lindl total alkaloids can be used as the additive components for preparing the shampoo.

The foregoing is merely an example of the present invention and common general knowledge of known specific structures and features of the embodiments is not described herein in any greater detail. It should be noted that, for those skilled in the art, without departing from the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the invention is to be determined by the claims, and the description of the embodiments and the like in the specification is intended to explain the contents of the claims.

The embodiments of the present invention have been described in detail, and the principle and the implementation of the present invention are explained in the present document by applying specific embodiments, and the above description of the embodiments is only used to help understanding the method of the present invention and the core idea thereof. Meanwhile, those skilled in the art should also be able to make modifications or variations to the present invention based on the detailed description of the invention and the scope of the application, which falls within the scope of the protection of the present invention. In view of the above, the present disclosure should not be construed as limiting the invention.

Claims

1. A dendrobe shampoo is characterized by comprising dendrobe total alkaloids and pharmaceutically acceptable auxiliary materials.

2. The dendrobe shampoo as claimed in claim 1, wherein the dendrobe is dendrobium nobile.

3. The dendrobe shampoo as claimed in claim 1, wherein the dendrobe shampoo does not comprise silicone oil.

4. The dendrobe shampoo as claimed in claim 1, wherein the auxiliary materials comprise one or more selected from the following: ammonium laureth sulfate, ammonium lauryl sulfate and cocamidopropyl theine.

5. The dendrobe shampoo according to claim 4, wherein the weight ratio of the dendrobe total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl sutheophylline is 1 (1-60) to 1-60;

preferably, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine is 1 (1-60) to 1-30 (1-40);

more preferably, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine is 1 (20-60): 10-30): 10-40;

preferably, the weight ratio of the dendrobium total alkaloids, the ammonium laureth sulfate, the ammonium lauryl sulfate and the cocamidopropyl theine is 1 (20-60): 15-30): 15-40;

most preferably, the weight ratio between said dendrobium total alkaloids, said ammonium laureth sulfate, said ammonium lauryl sulfate and said cocamidopropyl sutheophylline ranges from 1.

6. The dendrobe shampoo of claim 4, wherein the weight percentage of the dendrobe total alkaloids in the dendrobe shampoo is in the range of 0.2-1%, preferably 0.2-0.4%, and preferably about 0.4%;

more preferably, the weight percentage of the ammonium laureth sulfate in the dendrobium shampoo is in the range of 5% to 20%, preferably 8% to 12%, and still more preferably about 8%;

particularly preferably, the weight percentage of the ammonium lauryl sulfate in the dendrobium stem shampoo is in the range of 2% to 10%, preferably 4% to 6%, and still more preferably about 6%;

more particularly preferably, the weight percentage of the cocamidopropyl rubusine in the dendrobium shampoo ranges from 2% to 10%, preferably from 4% to 8%, and still more preferably about 6%.

7. The dendrobe shampoo as claimed in claim 4, wherein the auxiliary materials further comprise one or more selected from the group consisting of: coconut oil diethanolamide, guar gum hydroxypropyl trimethyl ammonium chloride, EDTA disodium, polyquaternium-7, pyridone ethanolamine salt, pearly luster slurry, panthenol, glycerol, sodium lauroyl glutamate, sodium lauroyl sarcosinate, sodium chloride, citric acid, polyethylene glycol 6000 distearate, DMDM hydantoin and carbazone.

8. The dendrobe shampoo as claimed in claim 1, wherein the dendrobe shampoo further comprises an aloe extract.

9. A method for preparing dendrobium stem shampoo is characterized by comprising the step of mixing dendrobium stem total alkaloids and a proper amount of pharmaceutically acceptable auxiliary materials.

10. Method according to claim 9, characterized in that it comprises the following steps:

(2) Dissolving cationic guar gum hydroxypropyl trimethyl ammonium chloride in an aqueous solution containing coconut oil diethanolamide to obtain a second solution;

(3) Adding EDTA disodium, sodium chloride and citric acid into water, dissolving, adding ammonium laureth sulfate and ammonium lauryl sulfate, and mixing to obtain a third solution;

(8) Mixing the seventh solution with the pearlescent slurry and glycerol to obtain an eighth solution;

(13) Mixing the twelfth solution with the casuarina and the DMDM hydantoin to obtain the dendrobe shampoo;

preferably, a stirring step is further included in steps (2), (4), (5), (7), (8), (10), (11), (12) and (13);

more preferably, the stirring time is 5-30 min;

particularly preferably, in step (3), the ammonium laureth sulfate and/or the ammonium lauryl sulfate are dissolved by ultrasonic dissolution or by a homogenizing mixer;

most preferably, in step (3), the ammonium laureth sulfate and/or the ammonium lauryl sulfate are dissolved by sonication.