CN115262222B - 一种穴位埋植线的表面改性处理方法和装置 - Google Patents
一种穴位埋植线的表面改性处理方法和装置 Download PDFInfo
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Abstract
本发明公开了一种穴位埋植线的表面改性处理方法,包括步骤:(1)以生物可降解埋植线作为表面改性的基材;(2)将埋植线用酒精溶液浸泡后干燥;(3)将埋植线放入双氧水中,同时进行超声波处理以进行表面改性;(4)对埋植线进行冷冻干燥。本发明涉及的改性材料如乙醇、双氧水均为常见的化学试剂;所涉及的改性仪器如超声波仪等均为易得设备;所涉及的处理工艺如酒精浸泡、冷冻干燥等均为易于操作的方法。
Description
技术领域
本发明涉及纺织纤维表面处理技术,尤其涉及一种穴位埋植线的表面改性和装置。
背景技术
穴位埋线法,即采用一次性埋线针将生物可降解材料植入人体的某个穴位,通过埋植材料对穴位的刺激作用,起到治疗疾病的目的。当前有一些关于穴位埋植线表面性能改性的专利,如:一种针灸埋植材料(CN 103301510 A),但所涉及的亲水性多糖改性材料,如:黄原胶、魔芋胶、预糊化淀粉、羧甲基纤维素、海藻酸钠、刺槐胶、卡拉胶、瓜尔胶、***胶、琼脂、葡聚糖或水溶性甲壳胺等,在产生膨胀效应的同时,也对埋植线材料的物化性能造成一定损伤。又如:一种具有自膨胀效应的复合纤维及其制备方法和烘干装置(专利号:CN 106436314 A),其所涉及单丝表面的预处理方式如:等离子体表面刻蚀、酸表面刻蚀、碱表面刻蚀、有机溶剂等表面刻蚀技术相对单一,导致表面改性效果不足。还有:可降解材料缝合线在穴位埋植线中的应用(专利号:200510028490.7),所述生物可降解材料埋植线虽替代了传统的羊肠线,但其表面未经任何处理,亲水性和细胞增殖性能较差。总之,以上方法均不能较好的解决穴位埋植线表面性能差、亲水性能弱等难题。
本发明旨在提供一种操作简单、安全可靠、针对性强的表面改性处理方法,改性对象为聚乳酸(PLA)、聚乙交酯(PGA)、聚己内酯(PCL)、聚乙丙交酯(PGLA)等生物可降解材料线体,可以弥补现有埋植线表面改性处理方法的不足,有效提高穴位埋植线的亲水性等表面性能。
发明内容
有鉴于现有技术的上述缺陷,本发明所要解决的技术问题是如何提高穴位埋植线的表面性能。
为实现上述目的,本发明首先提供了一种穴位埋植线的表面改性处理方法,包括步骤:
(1)以生物可降解埋植线作为表面改性的基材;
(2)将埋植线用酒精溶液浸泡后干燥;
(3)将埋植线放入双氧水中,同时进行超声波处理以进行表面改性;
(4)对埋植线进行冷冻干燥。
进一步地,埋植线为聚乳酸(PLA)、聚乙交酯(PGA)、聚己内酯(PCL)或聚乙丙交酯(PGLA)埋植线。
进一步地,步骤(2)中,酒精溶液浓度为体积分数75%。
进一步地,步骤(3)中,双氧水浓度为75%;超声频率为25kHz-130kHz;超声作用时间为1-60min。
进一步地,步骤(4)中,冷冻温度≤0℃,冷冻时间≥30min。
进一步地,在步骤(3)中,提供了一内装有双氧水的超声波处理槽;超声波处理槽内,双氧水液面下,设置有第一卷线辊和第二卷线辊;进入超声波处理槽的埋植线以逆时针的卷绕方向引入第一卷线辊,此时埋植线的第一半圆面朝外;埋植线通过第一卷线辊后,又以顺时针的卷绕方向绕入第二卷线辊,使得埋植线的第二半圆面朝外。
进一步地,第一卷线辊和第二卷线辊在水平方向上一前一后,在高度方向上一上一下的错开设置。
进一步地,通过调整埋植线在卷线辊上的卷绕圈数调整埋植线在双氧水中的浸泡时间。
本发明还提供了一种穴位埋植线的表面改性处理装置,其特征在于,内装有双氧水的超声波处理槽;超声波处理槽内,双氧水液面下,设置有第一卷线辊和第二卷线辊;第一卷线辊和第二卷线辊被设置为使得进入超声波处理槽的埋植线以逆时针的卷绕方向引入第一卷线辊,此时埋植线的第一半圆面朝外;埋植线通过第一卷线辊后,又以顺时针的卷绕方向绕入第二卷线辊,此时埋植线的第二半圆面朝外。
进一步地,第一卷线辊和第二卷线辊在水平方向上一前一后,在高度方向上一上一下的错开设置。
相比于现有穴位埋植线的表面改性技术,本发明具备以下优势:
(1)操作简单且易于实现:本发明涉及的改性材料如乙醇、双氧水均为常见的化学试剂;所涉及的改性仪器如超声波仪等均为易得设备;所涉及的处理工艺如酒精浸泡、冷冻干燥等均为易于操作的方法。
(2)表面改性效果显著:本发明利用双氧水的氧化性和弱酸性,考虑超声波改性的空化性,结合两者改性的优势实施联合处理技术,有效提高了穴位埋植线的亲水性等表面性能。
(3)适用对象广泛:本发明可针对多种生物可降解埋植线,如聚乳酸(PLA)、聚乙交酯(PGA)、聚己内酯(PCL)、聚乙丙交酯(PGLA)等,具有普遍适用性。
以下将结合附图对本发明的构思、具体结构及产生的技术效果作进一步说明,以充分地了解本发明的目的、特征和效果。
附图说明
图1是本发明的一个较佳实施例中的实验室内穴位埋植线的表面改性原理示意图;
图2是本发明的一个较佳实施例中的工业生产中穴位埋植线的表面改性过程俯视图;
图3是本发明的一个较佳实施例中的工业生产中穴位埋植线的表面改性过程侧视图;
图4是本发明的一个较佳实施例中的工业生产中穴位埋植线的横截面图。
具体实施方式
以下参考说明书附图介绍本发明的多个优选实施例,使其技术内容更加清楚和便于理解。本发明可以通过许多不同形式的实施例来得以体现,本发明的保护范围并非仅限于文中提到的实施例。
实施例1-3请参见图1。其中1为固定装置,2为烧杯,3为双氧水溶液,4为埋植线,5为超声波处理仪。
实施例1
聚乳酸埋植线的改性处理:
1、将聚乳酸埋植线剪切成2mm长度,然后浸泡在体积分数为75%的酒精溶液中20min,然后放置于鼓风干燥箱中30min,去除表面的水分。
2、将预处理后的试样放入盛有浓度为28%的双氧水溶液烧杯中,随后将浸泡试样的烧杯放入超声仪装置内部,调整超声波频率60kHz,作用时间45min。
3、将改性后的试样在冷冻干燥机中预制冷30min,随后将改性后的试样放入冷冻干燥机中,设置冷冻干燥机的真空度为50Pa,冷冻时间为30min。
实施例2
聚乙交酯埋植线的改性处理:
1、将聚乙交酯埋植线剪切成3mm长度,然后浸泡在体积分数为75%的酒精溶液中30min,然后放置于鼓风干燥箱中20min,去除表面的水分。
2、将预处理后的试样放入盛有浓度为30%的双氧水溶液烧杯中,随后将浸泡试样的烧杯放入超声仪装置内部,调整超声波频率100kHz,作用时间60min。
3、将改性后的试样在冷冻干燥机中预制冷30min,随后将改性后的试样放入冷冻干燥机中,设置冷冻干燥机的真空度为100Pa,冷冻时间为20min。
实施例3
聚乙丙交酯埋植线的改性处理:
1、将聚乙丙交酯埋植线剪切成2.5mm长度,然后浸泡在体积分数为75%的酒精溶液中25min,然后放置于鼓风干燥箱中20min,去除表面的水分。
2、将预处理后的试样放入盛有浓度为35%的双氧水溶液烧杯中,随后将浸泡试样的烧杯放入超声仪装置内部,调整超声波频率120kHz,作用时间25min。
3、将改性后的试样在冷冻干燥机中预制冷30min,随后将改性后的试样放入冷冻干燥机中,设置冷冻干燥机的真空度为60Pa,冷冻时间为40min。
实施例4请参见图2-4。
实施例4
在本实施例中,原理与实施例1-3相同,但进行处理的为实际工业生产中连续的埋植线,通过将埋植线连续地通过装有双氧水11的超声波处理槽10以对其表面进行一段时间的超声波和双氧水联合表面改性处理。在超声波处理槽10内设置有第一卷线辊12和第二卷线辊13。埋植线自线头14a处以逆时针的卷绕方向引入第一卷线辊12。此时,埋植线的A侧朝外,而B侧接触第一卷线辊12表面。埋植线通过第一卷线辊12后,又以顺时针的卷绕方向绕入第二卷线辊13,并自线头14b处引出。此时,埋植线的B侧朝外,而A侧接触第一卷线辊12表面。这样,使得在超声波处理槽10中进行表面处理时,埋植线可在卷绕状态下实现了“翻面”的效果,从而其A、B两侧可分别在相等时间与双氧水11进行接触,并以相同的状态接受超声处理,使得埋植线的表面改性处理更为彻底、全面和均匀。同时,埋植线在超声波处理槽10内的处理时间,可通过调整其在卷线辊上的卷绕圈数进行调整。
在本实施例中,第一卷线辊12和第二卷线辊13在水平方向上一前一后,在高度方向上一上一下的错开设置。以上详细描述了本发明的较佳具体实施例。应当理解,本领域的普通技术无需创造性劳动就可以根据本发明的构思作出诸多修改和变化。因此,凡本技术领域中技术人员依本发明的构思在现有技术的基础上通过逻辑分析、推理或者有限的实验可以得到的技术方案,皆应在由权利要求书所确定的保护范围内。
Claims (7)
1.一种穴位埋植线的表面改性处理方法,其特征在于,包括步骤:
(1)以生物可降解埋植线作为表面改性的基材;
(2)将埋植线用酒精溶液浸泡后干燥;
(3)将埋植线放入双氧水中,同时进行超声波处理以进行表面改性;
(4)对埋植线进行冷冻干燥;
在步骤(3)中,提供了一内装有双氧水的超声波处理槽;超声波处理槽内,双氧水液面下,设置有第一卷线辊和第二卷线辊;进入超声波处理槽的埋植线以逆时针的卷绕方向引入第一卷线辊,此时埋植线的第一半圆面朝外;埋植线通过第一卷线辊后,又以顺时针的卷绕方向绕入第二卷线辊,使得埋植线的第二半圆面朝外;
第一卷线辊和第二卷线辊在水平方向上一前一后,在高度方向上一上一下的错开设置;
埋植线在第一卷线辊和第二卷线辊上均平行地卷绕有多圈。
2.如权利要求1所述的穴位埋植线的表面改性处理方法,其中,步骤(1)中,埋植线为聚乳酸(PLA)、聚乙交酯(PGA)、聚己内酯(PCL)或聚乙丙交酯(PGLA)埋植线。
3.如权利要求1所述的穴位埋植线的表面改性处理方法,其中,步骤(2)中,酒精溶液浓度为体积分数75%。
4.如权利要求1所述的穴位埋植线的表面改性处理方法,其中,步骤(3)中,双氧水浓度为75%;超声频率为25kHz-130kHz;超声作用时间为1-60min。
5.如权利要求1所述的穴位埋植线的表面改性处理方法,其中,步骤(4)中,冷冻温度≤0℃,冷冻时间≥30min。
6.如权利要求1所述的穴位埋植线的表面改性处理方法,其中,通过调整埋植线在卷线辊上的卷绕圈数调整埋植线在双氧水中的浸泡时间。
7.一种穴位埋植线的表面改性处理装置,其特征在于,包括内装有双氧水的超声波处理槽;超声波处理槽内,双氧水液面下,设置有第一卷线辊和第二卷线辊;第一卷线辊和第二卷线辊被设置为使得进入超声波处理槽的埋植线以逆时针的卷绕方向引入第一卷线辊,此时埋植线的第一半圆面朝外;埋植线通过第一卷线辊后,又以顺时针的卷绕方向绕入第二卷线辊,此时埋植线的第二半圆面朝外;
其中,第一卷线辊和第二卷线辊在水平方向上一前一后,在高度方向上一上一下的错开设置。
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