CN115251375A - (R) -3-hydroxybutyric acid ketonic product and preparation method thereof - Google Patents

(R) -3-hydroxybutyric acid ketonic product and preparation method thereof Download PDF

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CN115251375A
CN115251375A CN202210809325.9A CN202210809325A CN115251375A CN 115251375 A CN115251375 A CN 115251375A CN 202210809325 A CN202210809325 A CN 202210809325A CN 115251375 A CN115251375 A CN 115251375A
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hydroxybutyric acid
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hydroxybutyrate
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薛凌云
陈镇聪
戴宏海
吕金艳
余柳松
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Zhuhai Medfa Biotechnology Co ltd
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Abstract

The invention discloses a (R) -3-hydroxybutyric acid ketonic product and a preparation method thereof, wherein the product comprises the following components: 2-25 parts of (R) -3-hydroxybutyric acid solid, 5-20 parts of (R) -3-hydroxybutyrate and 5-20 parts of medium-chain triglyceride microcapsule powder; the (R) -3-hydroxybutyric acid solid is prepared from (R) -3-hydroxybutyric acid liquid and solid filler, and may further comprise one or more of sweetener, food essence and sugar. The ketogenic product can effectively solve the problems that the (R) -3-hydroxybutyric acid functional solid product is short and the liquid (R) -3-hydroxybutyric acid product is inconvenient to apply in the market; meanwhile, the effects of effectively improving blood ketone and prolonging blood ketone time can be achieved, and the aims of quickly generating ketone and solving the problem that people groups such as health, weight loss and the like need to quickly generate ketone are achieved.

Description

(R) -3-hydroxybutyric acid ketonic product and preparation method thereof
Technical Field
The invention relates to the field of functional foods, in particular to a (R) -3-hydroxybutyric acid ketonic product and a preparation method thereof.
Background
(R) -3-hydroxybutyric acid is one of three ketone bodies (R) -3-hydroxybutyric acid, acetoacetic acid and acetone) produced by energy provided by fat metabolism in human body, and accounts for about 70% of the three substances. In mammals, (R) -3-hydroxybutyrate is produced by fat metabolism in the liver, is transported to other tissues and organs by blood, and is oxidized in the mitochondria of cells to produce energy. In recent years, more and more scientific researches show that (R) -3-hydroxybutyric acid not only can be used as an energy source, but also has various health benefits for human bodies, and research reports in the aspect of medicines are continuously reported.
At present, (R) -3-hydroxybutyric acid similar products in the market are mainly (R) -3-hydroxybutyrate and (R) -3-hydroxybutyrate ester, are mainly applied to the fields of ketogenic diet weight loss, high-strength professional sports, energy improvement, cognition improvement and the like, and are mainly distributed in countries such as the United states. The (R) -3-hydroxybutyrate is basically a racemic body prepared by a chemical method, and researches show that the (S) -3-hydroxybutyrate in the racemic body has no physiological activity, and the (R) -3-hydroxybutyrate is mainly a product on the market in America, is inconvenient to use, has high acidity, is particularly bitter in taste, is difficult to accept, has poor palatability, and needs to be metabolized by the liver in the human body.
At present, the ketogenic products on the market mainly take MCT (medium chain triglyceride) raw materials, but the MCT needs to be taken in a large amount and is not easy to become full, eaters need strong perseverance to stand hunger, and the MCT needs a metabolic process to be converted into ketone bodies step by step, the ketogenic process is long, and a long time is needed when the MCT is matched with other ketogenic foods. Therefore, the prior ketogenic product has single structure, poor ketogenic effect and pain in the ketogenic process.
The melting point of (R) -3-hydroxybutyric acid is low, and the pure crystal may be liquefied at room temperature. The pH value of liquid (R) -3-hydroxybutyric acid is low, and the requirements on equipment for storage, transportation and preparation of terminal products are high, so that the development of a solid functional product of (R) -3-hydroxybutyric acid is urgently needed at present.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides an (R) -3-hydroxybutyric acid ketonic product and a preparation method thereof, which can effectively solve the problems that the (R) -3-hydroxybutyric acid functional solid product is lack and the liquid (R) -3-hydroxybutyric acid product is inconvenient to apply in the market; meanwhile, the effects of effectively improving blood ketone and prolonging blood ketone time can be achieved, and the aims of quickly generating ketone and solving the problem that people groups such as health, weight loss and the like need to quickly generate ketone are achieved.
The invention provides a (R) -3-hydroxybutyric acid ketogenic product, which comprises the following components:
2-25 parts by weight of (R) -3-hydroxybutyric acid solid;
5-20 parts by weight of (R) -3-hydroxybutyrate;
5-20 parts of medium chain triglyceride microcapsule powder;
the (R) -3-hydroxybutyric acid solid is prepared from (R) -3-hydroxybutyric acid liquid and solid filler, wherein the content of the (R) -3-hydroxybutyric acid liquid is 10-30wt%, and when the content is higher than 30wt%, the liquid is difficult to dry into powder solid, and the liquid is difficult to compound with other solid powder to synthesize into solid powder product, preferably 22-27wt%, and the solid filler is 70-90wt%.
Further, the solid (R) -3-hydroxybutyric acid is preferably 5 to 10 parts by weight, and when it is too large, the amount of the other two components is small, resulting in poor ketogenic effect.
Further, the (R) -3-hydroxybutyrate is selected from any one or more of sodium (R) -3-hydroxybutyrate, potassium (R) -3-hydroxybutyrate, calcium (R) -3-hydroxybutyrate, and magnesium (R) -3-hydroxybutyrate. Preferably 8 to 12 parts by weight, too much causes a large ion intake in the human body, causing electrolyte disorder.
Further, the medium chain fatty acids in the Medium Chain Triglyceride (MCT) microcapsule powder are composed of C8-C12 fatty acids, preferably a combination of C8 and C10. The C8 and C10 fatty acids are natural and extractable mixed substances, and the coconut oil and the palm oil have high content and are also main extracted raw materials. The microencapsulated powder is a solid powder that can be freely mixed to form a solid product, is commercially available, is a pure medium chain triglyceride liquid, is difficult to mix with other solids, and is not suitable for dosage forms. The MCT microcapsule powder is preferably 5-15 parts by weight, and MCT generates ketone relatively slowly.
Further, the (R) -3-hydroxybutyric acid ketonic product also comprises any one or more of a sweetening agent, a food flavor and sugar.
Further, the solid filler is selected from any one or more of corn starch, resistant dextrin, modified starch, sodium starch octenyl succinate, hydroxypropyl methyl cellulose, ethyl cellulose and poly 3-hydroxy fatty acid ester.
Further, the sweetener is selected from one or more of stevioside, sucralose, erythritol, momordica grosvenori extract, neotame, xylitol and maltitol. The dosage of the sweetening agent is 0.01 to 0.5 weight portion.
Further, the food essence is selected from solid powder essence, and is selected from any one or more of green lemon, grape, apple, strawberry, pineapple and white peach. The amount of the food essence is 0.1-2 parts by weight.
Further, the sugar is selected from one or two of white granulated sugar and glucose. The sugar is used in an amount of 0 to 10 parts by weight, preferably 3 to 6 parts by weight.
The invention also provides a preparation method of the (R) -3-hydroxybutyric acid ketonic product, which comprises the following steps:
s1: preparing (R) -3-hydroxybutyric acid solid;
s2: weighing (R) -3-hydroxybutyric acid solid prepared by the step S1, the (R) -3-hydroxybutyrate, the medium-chain triglyceride microcapsule powder, the food essence, the sweetening agent and the sugar according to the weight parts, and uniformly mixing.
S3: filling the mixture into the (R) -3-hydroxybutyric acid ketogenic product.
Further, the step S1 includes the steps of:
(1) Adding a solid filler into a wet granulator;
(2) Adjusting the parameters to 800-1200rpm;
(3) Opening the cutter to 600-1200rpm;
(4) Slowly adding liquid (R) -3-hydroxybutyric acid into the liquid adding port, and uniformly mixing and stirring;
(5) Discharging and drying to obtain the (R) -3-hydroxybutyric acid solid.
Further, the step S1 uses a spray drying fluidized bed apparatus.
In the preparation process of the ketogenic solid product, liquid (R) -3-hydroxybutyric acid is required to be used as a raw material to prepare (R) -3-hydroxybutyric acid solid, MCT microcapsule powder is microencapsulated powder solid formed by embedding MCT oil through a starch wall material and can be purchased in the market, and no commercially available product exists in the (R) -3-hydroxybutyric acid solid in the market at present.
In summary, compared with the prior art, the invention achieves the following technical effects:
(1) The product prepared by the invention is a (R) -3-hydroxybutyric acid ketogenic product, namely a first solid ketogenic product formed by compounding (R) -3-hydroxybutyric acid liquid, (R) -3-hydroxybutyrate and MCT. Can be used for various health requirements brought by ketogenesis, such as exercise energy supply, cognition improvement, weight reduction and other fields.
(2) The product can rapidly provide ketone bodies from (R) -3-hydroxybutyric acid, the (R) -3-hydroxybutyric acid salt is subsequently metabolized and enters blood to maintain and increase the blood ketone value, and MCT is finally metabolized and then continuously maintains the blood ketone value, so that the effects of promoting blood ketone by the synergistic combination of the front part, the middle part and the rear part, prolonging the blood ketone stabilization time and the like are achieved.
(3) The product combination simultaneously avoids the peracid of the (R) -3-hydroxybutyric acid liquid beverage product, and has poor palatability; the (R) -3-hydroxybutyrate products are bitter, astringent, salty and the like, and have poor mouthfeel, and the problems of overproof salt ions, damage to liver and kidney functions and the like caused by large-scale eating; meanwhile, the problem of slow ketone generation effect of single MCT raw material is avoided.
(4) The solid product of the ketogenic is convenient to carry and transport, can be directly mixed with water during use, and has good palatability.
(5) The solid product does not need to be added with preservative, and has no side effect after long-term use.
(6) The invention provides a preparation method of R-3 hydroxybutyric acid solid, and only when the solid is prepared, the solid can be compounded with other two products to prepare a terminal product.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 shows the comparison of blood ketone values of different ketogenic products of the present invention.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making creative efforts based on the embodiments in the present invention, shall fall within the protection scope of the present invention.
The (R) -3-hydroxybutyrate has small molecules, can be directly absorbed by intestinal tracts and enters blood, and does not need to be metabolized by the liver; the (R) -3-hydroxybutyric acid esters are generally prepared by dehydrating and condensing (R) -3-hydroxybutyric acid with one or two (1, 3) butanediol, or with other alcohols which are metabolized in vivo and then converted into (R) -3-hydroxybutyric acid. Needs to be metabolized by the liver in human body to generate (R) -3-hydroxybutyric acid, and then enters into cells of various components of the body to play a role through blood flow. (R) -3-Hydroxybutanoate vs (R) -3-hydroxyThe butyrate has the advantages that on one hand, the effect of blood ketone rising is quick, and the burden of the liver is not increased; on the other hand, the (R) -3-hydroxybutyrate is solid, and can form compounding advantage with other solids by higher content. The (R) -3-hydroxybutyrate ester is a liquid, and is prepared as a solid preparation, requiring a cumbersome process, so that the ester content may be reduced, and the cost may be greatly increased. Therefore, the invention solves the problem by compounding three components of (R) -3-hydroxybutyric acid solid, (R) -3-hydroxybutyrate and medium chain triglyceride microcapsule powder
Figure BDA0003739928300000051
The liquid product of the 3-hydroxybutyric acid is inconvenient to use, high in acidity and poor in palatability, and the existing ketogenic product has the problems of single structure, poor ketogenic effect and pain in the ketogenic process.
The preparation method of the ketogenic solid product comprises the following steps:
(1) Adding a solid filler into a wet granulator;
(2) Adjusting parameters to a proper mixing revolution;
(3) Opening the cutter to a proper revolution;
(4) Slowly adding liquid (R) -3-hydroxybutyric acid into the liquid adding port, and mixing and stirring uniformly;
(5) Discharging and drying;
(6) Uniformly mixing (R) -3-hydroxybutyric acid, medium-chain triglyceride microcapsule powder, (R) -3-hydroxybutyric acid salt, food essence, sweetener and sugar with different masses.
(7) Filling into final product by filling machine.
The above (1) to (5) can also be carried out by a spray-drying fluidized bed apparatus to prepare a solid of R-3 hydroxybutyric acid.
The following examples use the source of the raw materials:
corn starch: koch Biotechnology Shanghai, inc.;
(R) -3-hydroxybutyric acid 50: mcTagetes Sci Ltd;
50% of medium chain triglyceride microcapsule powder: the content of medium chain triglyceride in the microcapsule powder is 50wt%, sienhasff biotechnology limited;
75% of medium chain triglyceride microcapsule powder: the content of medium chain triglyceride in the microcapsule powder is 75wt%, sienhasff biotechnology limited;
pineapple powder essence for food: aipu essence and flavor Co., ltd;
white peach powder essence for food: aipu essence and flavor Co., ltd;
sucralose: wuhan Wanrong science and technology development Limited;
white granulated sugar: jinan Luhui chemical Co., ltd.
Example 1
(1) Taking 15 parts by weight of rice starch, and adding the rice starch into a wet granulator material kettle at room temperature;
(2) Adjusting the stirring speed of the wet preparation to be 1000rpm/min and the rotating speed of a cutter to be 1000rpm/min;
(3) Starting the wet granulator;
(4) Slowly adding liquid (R) -3-hydroxybutyric acid into the liquid adding port, wherein the content of (R) -3-hydroxybutyric acid in the product is about 50%, the weight of the aqueous solution is 10 parts, and the feed liquid is completely added within 5 minutes;
(5) After the liquid (R) -3-hydroxybutyric acid is added, the cutter and the stirring are continuously operated for 10 minutes;
(6) Stopping the wet granulator, and drying in a drying oven at 60 ℃ for 5 hours;
(7) Granulating with a swing granulator, and sieving with a 30-mesh sieve to obtain powder with (R) -3-hydroxybutyric acid content of 25%;
(8) Taking 10 parts by weight of the powder prepared in the step (7), adding 50 percent of medium-chain triglyceride microcapsule powder, and uniformly mixing the 10 parts by weight of the sodium (R) -3-hydroxybutyrate, 0.2 part by weight of pineapple powder essence for food, 0.01 part by weight of sucralose and 2 parts by weight of white granulated sugar. In this powder, (R) -3-hydroxybutyric acid was 8.3%, the (R) -3-hydroxybutyrate was 26.6%, and the MCT was 16.6%.
Example 2
(1) Taking 10 parts by weight of corn starch, and adding the corn starch into a material kettle of a wet granulator at room temperature;
(2) Adjusting the stirring speed of the wet preparation to 1200rpm/min and the rotation speed of a cutter to 1200rpm/min;
(3) Starting the wet granulator;
(4) Slowly adding 8.5 parts by weight of liquid (R) -3-hydroxybutyric acid 50 aqueous solution into a liquid adding port, and finishing adding the feed liquid within 8 minutes;
(5) After the liquid (R) -3-hydroxybutyric acid is added, the cutter and the stirring are continuously operated for 10 minutes;
(6) Stopping the wet granulator, and drying for 6 hours in a drying oven at 70 ℃;
(7) And (3) finishing the granules by a swinging granulator with a screen of 30 meshes, wherein the content of the (R) -3-hydroxybutyric acid in the obtained powder is 30 percent, and the flowability of the solid powder is poor.
(8) Taking 10 parts by weight of the powder prepared in the step (7), adding 50 percent of medium-chain triglyceride micro-capsule powder, mixing the mixture, 7 parts by weight of potassium (R) -3-hydroxybutyrate (the proportion of C8 and C10 is 60: 40), 0.1 part by weight of lemon powder essence for food and 0.1 part by weight of sucralose, and uniformly mixing the components. In this powder, the content of (R) -3-hydroxybutyric acid was 11.0%, the content of (R) -3-hydroxybutyric acid salt was 25.7%, and the content of MCT was 18.4%.
Example 3
Taking 10 parts by weight of the (R) -3-hydroxybutyric acid solid powder obtained in step 7 of example 1, adding 75 parts by weight of medium-chain triglyceride microcapsule powder (the proportion of C8 and C10 is 60: 40), 10 parts by weight of calcium (R) -3-hydroxybutyric acid, 0.3 part by weight of white peach powder essence for food, 0.03 part by weight of sucralose and 5 parts by weight of white granulated sugar, and mixing uniformly. In this powder, the content of (R) -3-hydroxybutyric acid was 8.5%, the content of (R) -3-hydroxybutyric acid salt was 30.0%, and the content of MCT was 22.5%.
Example 4
Taking 5 parts by weight of the solid (R) -3-hydroxybutyric acid powder obtained in step 7 of example 1, adding 75 parts by weight of medium-chain triglyceride micro-capsule powder, 10 parts by weight of sodium (R) -3-hydroxybutyric acid, 0.15 part by weight of white peach powder essence for food and 0.02 part by weight of sucralose, and mixing uniformly. In this powder, (R) -3-hydroxybutyric acid content was 5.0%, the (R) -3-hydroxybutyrate content was 39.7%, and MCT content was 29.8%.
Example 5
30g of the green ketone product obtained in example 3, 2.6g of (R) -3-hydroxybutyric acid and 6.7g of MCT; 9g of (R) -3-hydroxybutyric acid, in terms of (R) -3-hydroxybutyric acid, was approximately 7.2g; 60mL of (R) -3-hydroxybutyric acid 10% solid beverage, which is equivalent to 6g of (R) -3-hydroxybutyric acid; the MCT micro-capsule powder accounts for 10g, equivalent to 5g MCT, accounting for 50 percent; respectively dissolving in 150-200mL warm water, drinking 1 product every 3 days under the same state condition for the same volunteer, adopting a finger tip blood collection mode at different drinking time periods, measuring blood ketone with a blood ketone meter, and inspecting the change of the blood ketone value of the drinker.
The (R) -3-hydroxybutyric acid liquid beverage has a particularly sour taste, and when diluted to 200mL, a large amount of sugar is added, so that the beverage is very sour, is not easy to drink by a drinker, and is easy to feel throat, gastric acid and flatulence. When the (R) -3-hydroxybutyric acid liquid beverage is drunk alone, the drinking amount is not suitable to exceed 6g in one day, otherwise, the liquid beverage can cause unpalatable reaction to drinkers and is difficult to continuously drink.
When the MCT microcapsule powder is drunk alone to improve the blood ketone, the drinker often has uncomfortable reactions such as nausea, vomit, abdominal pain, abdominal distension and the like, the user is difficult to insist, the blood ketone generating speed is high compared with the traditional diet, but the speed for (R) -3-hydroxybutyric acid and salts thereof is still low.
The combination of the (R) -3-hydroxybutyric acid, the salt and the MCT micro-capsule powder can enable a drinker to achieve the effect of quickly increasing the blood ketone and keeping the blood ketone value stable, so that a person needing to produce the ketone can achieve the effect of producing the ketone in a relaxed state, and the discomfort of the ketone producing process such as hunger, stomach discomfort, abdominal discomfort and the like can be avoided because the time is consumed for half a month or even more than one month like the traditional ketone producing diet.
When volunteers drink the different ketogenic products, the (R) -3-hydroxybutyric acid and the (R) -3-hydroxybutyrate are poor in taste and strong in drinking discomfort when drinking the ketogenic products independently: MCT is not large in amount and can be relatively tolerated, so that the (R) -3-hydroxybutyric acid ketonic product disclosed by the invention is relatively good in taste and free of obvious discomfort. The blood ketone value curves of different drinks are shown in figure 1.
Comparative example 1
(1) Taking 10 parts by weight of corn starch, and adding the corn starch into a wet granulator material kettle at room temperature;
(2) Adjusting the stirring speed of the wet preparation to 1200rpm/min and the rotation speed of a cutter to 1200rpm/min;
(3) Starting the wet granulator;
(4) Slowly adding a liquid (R) -3-hydroxybutyric acid 50 product into a liquid adding port, wherein the weight of the aqueous solution is 15 parts, and the feed liquid is completely added within 10 minutes;
(5) After the liquid 3HB is added, the cutter and the stirring are continuously operated for 10 minutes;
(6) The wet granulator was stopped and dried in a drying oven at 80 ℃ for 8 hours, and the product could not be dried.
(7) After drying in a drying oven at 100 ℃ for 8 hours, the product can not be dried, and the (R) -3-hydroxybutyric acid is degraded, and the content of the by-product crotonic acid is increased to 1.0%.
Comparative example 1 shows that the amount of (R) -3-hydroxybutyric acid is limited, and that a load exceeding 30wt% does not become a dry solid.
Comparative example 2
Taking 5 parts by weight of the (R) -3-hydroxybutyric acid solid powder obtained in step (7) of example 2, adding 75 parts by weight of the medium-chain triglyceride micro-capsule powder, 5 parts by weight of the (R) -3-hydroxybutyric acid salt, 0.2 parts by weight of the white peach powder essence for food, and 0.03 parts by weight of sucralose, and mixing them uniformly. The powder had poor flowability and could not be packed into a solid drink in a ribbon form by a pellet filler.
Comparative example 2 shows that (R) -3-hydroxybutyric acid in the solid exceeded 30% by weight, the flowability of the prepared solid was poor, the flowability of the microencapsulated powder containing MCT at a content of 70% was also poor, and that a mixed solid beverage applicable to mass production could not be prepared when the content of both was relatively high and the content of (R) -3-hydroxybutyric acid salt was relatively low in the mixture.
By combining the above examples and comparative examples, the present invention discloses a (R) -3-hydroxybutyric acid ketonic product, which comprises the following components: 2-25 parts of (R) -3-hydroxybutyric acid solid, 5-20 parts of (R) -3-hydroxybutyrate and 5-20 parts of medium-chain triglyceride microcapsule powder; the (R) -3-hydroxybutyric acid solid is prepared from (R) -3-hydroxybutyric acid liquid and solid filler, and may further comprise one or more of sweetener, food essence and sugar. The ketogenic product can effectively solve the problems that the (R) -3-hydroxybutyric acid functional solid product is short and the liquid (R) -3-hydroxybutyric acid product is inconvenient to apply in the market; meanwhile, the effects of effectively increasing the blood ketone and prolonging the blood ketone time can be achieved, and the aims of quickly generating the ketone and solving the problem that people in health, weight loss and the like need to quickly generate the ketone are achieved.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the scope of the present invention, which is intended to cover any modifications, equivalents, improvements, etc. within the spirit and scope of the present invention.

Claims (11)

1. A (R) -3-hydroxybutyric acid ketonic product is characterized by comprising the following components:
2-25 parts by weight of (R) -3-hydroxybutyric acid solid;
5-20 parts by weight of (R) -3-hydroxybutyrate;
5-20 parts of medium chain triglyceride microcapsule powder;
the (R) -3-hydroxybutyric acid solid is prepared from (R) -3-hydroxybutyric acid liquid and a solid filler, wherein the weight percentage of the (R) -3-hydroxybutyric acid liquid is 10-30wt%; the solid filler accounts for 70-90wt%.
2. The ketogenic (R) -3-hydroxybutyrate product of claim 1, wherein the salt of (R) -3-hydroxybutyrate is selected from any one or more of sodium (R) -3-hydroxybutyrate, potassium (R) -3-hydroxybutyrate, calcium (R) -3-hydroxybutyrate, and magnesium (R) -3-hydroxybutyrate.
3. The (R) -3-hydroxybutanoic acid ketogenic product of claim 1, wherein the medium chain fatty acids in the medium chain triglyceride microencapsulation powder are comprised of C8-C12 fatty acids.
4. The (R) -3-hydroxybutyrate ketogenic product of claim 1, further comprising any one or more of a sweetener, a food flavor and sugar.
5. The (R) -3-hydroxybutanoic acid ketonic product of claim 1, wherein the solid filler is selected from any one or more of corn starch, resistant dextrin, modified starch, sodium starch octenyl succinate, hydroxypropyl methylcellulose, ethylcellulose, poly-3-hydroxy fatty acid esters.
6. The (R) -3-hydroxybutanoic acid ketonic product of claim 4, wherein the sweetener is selected from any one or more of steviol glycosides, sucralose, erythritol, lo Han Guo extract, neotame, xylitol, maltitol.
7. The (R) -3-hydroxybutyric acid ketonic product of claim 4, wherein the food flavor is selected from solid powder flavors selected from any one or more of lime, grape, apple, strawberry, pineapple, white peach.
8. The (R) -3-hydroxybutanoic acid ketogenic product of claim 4, wherein the sugar is selected from any one or both of white sugar, glucose.
9. The process for the preparation of a ketogenic (R) -3-hydroxybutyrate product of any one of claims 1 to 8, which comprises the steps of:
s1: preparing (R) -3-hydroxybutyric acid solid;
s2: weighing (R) -3-hydroxybutyric acid solid prepared by the step S1, the (R) -3-hydroxybutyrate, the medium-chain triglyceride microcapsule powder, the food essence, the sweetening agent and the sugar according to the weight parts, and uniformly mixing.
S3: and filling to obtain the (R) -3-hydroxybutyric acid ketonic product.
10. The method for preparing a ketogenic (R) -3-hydroxybutyrate product of claim 9, wherein said step S1 comprises the steps of:
(1) Adding a solid filler into a wet granulator;
(2) Adjusting the parameters to 800-1200rpm;
(3) Opening the cutter to 600-1200rpm;
(4) Slowly adding liquid (R) -3-hydroxybutyric acid into the liquid adding port, and uniformly mixing and stirring;
(5) Discharging and drying to obtain the (R) -3-hydroxybutyric acid solid.
11. The method for preparing a ketogenic (R) -3-hydroxybutyrate product of claim 9, wherein said step S1 uses a spray drying fluid bed apparatus.
CN202210809325.9A 2022-07-11 2022-07-11 (R) -3-hydroxybutyric acid ketonic product and preparation method thereof Pending CN115251375A (en)

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Publication number Priority date Publication date Assignee Title
US20140350105A1 (en) * 2013-03-19 2014-11-27 University Of South Florida Compositions and methods for producing elevated and sustained ketosis
CN111867576A (en) * 2017-11-22 2020-10-30 阿克塞斯全球科学有限责任公司 R-enantiomer enriched non-racemic beta-hydroxybutyrate compounds and compositions and methods of use thereof
US20210244690A1 (en) * 2020-02-06 2021-08-12 Axcess Global Sciences, Llc Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions
CN113660930A (en) * 2019-02-11 2021-11-16 阿克塞斯全球科学有限责任公司 Beta-hydroxybutyrate mixed salt-acid compositions and methods of use
CN113712140A (en) * 2021-09-13 2021-11-30 珠海麦得发生物科技股份有限公司 Solid beverage containing (R) -3-hydroxybutyric acid and preparation method thereof
CN113747890A (en) * 2019-02-11 2021-12-03 阿克塞斯全球科学有限责任公司 Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140350105A1 (en) * 2013-03-19 2014-11-27 University Of South Florida Compositions and methods for producing elevated and sustained ketosis
CN111867576A (en) * 2017-11-22 2020-10-30 阿克塞斯全球科学有限责任公司 R-enantiomer enriched non-racemic beta-hydroxybutyrate compounds and compositions and methods of use thereof
CN113660930A (en) * 2019-02-11 2021-11-16 阿克塞斯全球科学有限责任公司 Beta-hydroxybutyrate mixed salt-acid compositions and methods of use
CN113747890A (en) * 2019-02-11 2021-12-03 阿克塞斯全球科学有限责任公司 Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use
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CN113712140A (en) * 2021-09-13 2021-11-30 珠海麦得发生物科技股份有限公司 Solid beverage containing (R) -3-hydroxybutyric acid and preparation method thereof

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