CN115232734A - Pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof - Google Patents
Pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof Download PDFInfo
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- 230000005486 microgravity Effects 0.000 title claims abstract description 26
- 239000000725 suspension Substances 0.000 title claims abstract description 24
- 238000004088 simulation Methods 0.000 title claims abstract description 23
- 230000004071 biological effect Effects 0.000 title claims abstract description 16
- 230000033001 locomotion Effects 0.000 claims abstract description 34
- 239000012472 biological sample Substances 0.000 claims abstract description 29
- 239000011159 matrix material Substances 0.000 claims abstract description 16
- 230000005484 gravity Effects 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 4
- 239000013598 vector Substances 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 230000009347 mechanical transmission Effects 0.000 abstract description 4
- 239000011257 shell material Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000009987 spinning Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000011217 control strategy Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000005487 simulated microgravity Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/24—Gas permeable parts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/56—Floating elements
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/10—Rotating vessel
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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Abstract
A pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof. Relates to the technical field of microgravity environment simulation. The device comprises a box body 1, a control system 2 and a gas source 3, and further comprises a ball bowl support 5, a digital valve matrix module 4 and a spherical dish 6, wherein the ball bowl support 5 is provided with a ball socket for accommodating the spherical dish 6, and the surface of the ball socket is provided with an orifice 51; the gas source 3 is communicated with the throttling hole 51 through the digital valve matrix module 4 and a pneumatic pipeline 52; the air flow sprayed from the throttle hole 51 blows against the spherical dish 6, so that the spherical dish 6 is suspended in the ball socket of the bowl support 5 to perform random rotation motion. The invention fundamentally avoids the redundant influence of the mechanical transmission structure on the biological sample culture and the motion trail.
Description
Technical Field
The invention relates to the technical field of microgravity environment simulation, in particular to a non-contact pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof.
Background
The microgravity biological effect simulation device is biological test equipment which is used for simulating the response of a biological sample under a microgravity environment on the ground, but is not limited to microgravity biological effect simulation research in the field of space life science, and has wide application in other cell culture tests. At present, most of common structures are rotary bioreactors rotating around a single rotating shaft or double rotating shafts, wherein the random positioning instrument belonging to a double-shaft rotator structure is most widely applied.
Such as "CN112675929A, name: an integrated machine and a method for providing a simulated microgravity effect for biology adopt mechanical drive to fix a culture bottle in a clamp outer frame of a three-dimensional rotator, and the culture bottle is locked by a rubber pad and a screwing handle which are oppositely arranged; the three-dimensional rotator loaded with the culture bottle is fixed in the box body of the incubator through the magnetism of the rotating base and is connected with a power supply, and then the microgravity environment is simulated through the rotating speed of the display control screen provided with the first driving motor and the second driving motor.
However, for a random positioning instrument, the random positioning motion is not truly random, and is essentially a synthetic motion realized by the cooperative work of the motors of two rotating shafts controlled by a microcomputer based on a computer random number table; in addition, for the gyrator with the mechanical transmission structure, no matter what motion law is adopted, the biological sample in the culture dish is inevitably influenced by vibration and stress generated when the mechanical structure runs in the running process of the device, so that the motion characteristics of the fluid and the biological sample in the culture dish are disturbed, and the culture growth of the biological sample in the microgravity biological effect simulation test is additionally influenced.
Disclosure of Invention
Aiming at the technical problems, the invention provides a pneumatic suspension type three-dimensional microgravity biological effect simulation system which abandons the concept of mechanical driving, adopts a non-contact driving mode, utilizes the randomness of turbulent motion and further realizes suspension rotation random motion and application thereof.
The technical scheme of the invention is as follows: the device comprises a box body 1, a control system 2 and a gas source 3, and further comprises a ball bowl support 5, a digital valve matrix module 4 and a spherical dish 6, wherein the ball bowl support 5 is provided with a ball socket for accommodating the spherical dish 6, and the surface of the ball socket is provided with an orifice 51; the gas source 3 is communicated with the throttling hole 51 through the digital valve matrix module 4 and a pneumatic pipeline 52; the air flow sprayed from the throttle hole 51 blows against the spherical dish 6, so that the spherical dish 6 is suspended in the ball socket of the bowl support 5 to perform random rotation motion.
The orifice 51 of the socket surface includes a primary hole 511, a secondary hole 512, and a timing hole 513;
1 to 5 main holes 511 are uniformly distributed in the middle of the bottom of the ball socket and used for suspending the spherical dish 6 relative to the spherical bowl support 5;
the auxiliary holes 512 are arranged in a plurality of groups and are distributed around the main hole 511 in a crossed manner, and are used for forming turbulence on the spherical surface of the spherical dish 6 and promoting the spherical dish 6 to rotate randomly;
the speed regulation holes 513 are provided with 3-4 groups and are uniformly distributed in the middle upper part of the ball socket and are used for providing pneumatic flow in random rotation directions and regulating the rotation speed.
The digital valve matrix module 4 is provided with digital valves corresponding to the main hole 511, the auxiliary hole 512 and the speed regulation hole 513 one by one, and the digital valves are connected with the control system.
The air source 3 comprises an air pressure source 31, an air pump 32 and an overflow valve 33, and is used for supplying air to each digital valve.
The spherical dish 6 is formed by detachably screwing an upper hemispherical shell 61 and a lower hemispherical shell 62.
The spherical dish 6 comprises a body and a cover body 63, wherein the cover body 63 is in a spherical crown shape, a hole matched with the cover body 63 in shape is formed in the body, and the cover body 63 is connected with the hole in the body through a sealing threaded connection structure.
Distance measuring devices 7 are uniformly distributed on the opening edge of the ball bowl support 5 and used for collecting real-time position information of the ball bowl 6, and the distance measuring devices 7 are connected with the control system 2.
And limiting protection devices 8 are uniformly distributed on the opening edge of the ball bowl support 5.
The application of the pneumatic suspension type three-dimensional microgravity biological effect simulation system in biological sample culture takes the time less than or equal to MRT as a motion period, the random motion track of the biological sample in each motion period takes the biological sample as a coordinate system, and the sum of gravity vectors borne by the biological sample in each motion period is zero.
The invention forms stable gas flow field distribution by controlling a micro flow valve matrix in a pneumatic pipeline to directly drive the spherical culture dish, and utilizes the randomness of fluid turbulence to enable the spherical culture dish to generate suspension spinning motion, thereby solving the technical problem that the biological sample cannot generate real random motion trail in the culture dish in the background technology, eliminating the vibration and impact effect of a mechanical transmission structure on the fluid and the biological sample in the cell culture dish in the test process, and fundamentally avoiding the redundant influence of the mechanical transmission structure on the culture and motion trail of the biological sample.
Drawings
Figure 1 is a schematic view of the structure of the present invention,
FIG. 2 is a schematic diagram of the present invention for realizing the air-floating effect,
figure 3 is a pneumatic schematic of the present invention,
FIG. 4 is a schematic perspective view of a first embodiment of the spherical culture dish according to the present invention,
FIG. 5 is a schematic perspective view of a second embodiment of the spherical culture dish according to the present invention,
figure 6 is a schematic illustration of the arrangement of orifices in the inner surface of a bowl support of the present invention,
figure 7 is a schematic structural diagram of an optimized embodiment of the invention,
figure 8 is a schematic diagram of the operation of the present invention,
FIG. 9 is a first reference view showing the state of the biological sample in the spherical dish in the present invention,
FIG. 10 is a second view showing the state of the biological sample in the spherical dish according to the present invention,
FIG. 11 is a reference diagram III showing the state of the biological sample in the spherical dish in the present invention,
FIG. 12 is a fourth reference diagram showing the state of the biological sample in the spherical dish in the present invention.
In the figure 1 it is shown a box body,
2 is a control system, 21 is a control panel;
3 is an air source, 31 is an air pressure source, 32 is an air pump, and 33 is an overflow valve;
4 is a digital valve matrix module, 41 to 49 are digital valves one to nine;
5 is a ball bowl support, 51 is an orifice, 511 is a main hole, 512 is an auxiliary hole, 513 is a speed regulation hole, and 52 is a pneumatic pipeline;
6 is a spherical vessel, 61 is an upper hemispherical shell, 62 is a lower hemispherical shell, and 63 is a cover body;
7 is a distance measuring device;
8 is a limit protection device;
9 is the culture medium, 91 is the cell microcarrier;
in the figure, V1-9 is one to nine throttle holes;
XYZ in the figure is a three-dimensional reference coordinate system, and G is the gravity direction.
Detailed Description
The invention is further described below with reference to fig. 1-7. The invention discloses a pneumatic suspension type three-dimensional microgravity biological effect simulation system which comprises a box body 1, a control system 2 and a gas source 3, and further comprises a ball bowl support 5, a digital valve matrix module 4 and a spherical vessel 6, wherein the ball bowl support 5 is provided with a ball socket for accommodating the spherical vessel 6, and the surface of the ball socket is provided with an orifice 51; the gas source 3 is communicated with the throttling hole 51 through the digital valve matrix module 4 and a pneumatic pipeline 52; the air flow ejected from the orifice 51 blows against the spherical dish 6 so that the spherical dish 6 is suspended in the socket of the bowl support 5 for random rotational movement.
As shown in figure 1, the box body 1 of the invention is manufactured into an integrated box body structure with a plurality of chambers for the convenience of operation of a user, and a (microcomputer) control system 2 (comprising a control panel 21), an air source 3 (comprising a temperature control module), a digital valve matrix module 4 and an incubator module (comprising a ball bowl support 5 and a ball dish 6) are integrated into a whole. For example, the box body 1 can be designed into a sealing door with a transparent observation window, so that the inner space is independent, the inner wall and the outside are provided with one-way exhaust ports, an exhaust air duct, a gas filtering device and an auxiliary air guide fan are arranged inside the box body, and during the test, the gas treatment, the recovery and the discharge can be carried out in the incubator. An irradiation device can be arranged in the incubator body to provide illumination or irradiation for the interior of the incubator body. To meet the requirement of cell culture, or to perform ultraviolet disinfection of the incubator.
The orifice 51 of the socket surface includes a main hole 511, an auxiliary hole 512, and a speed adjusting hole 513;
1 to 5 main holes 511 are uniformly distributed in the middle of the bottom of the ball socket and used for enabling the spherical dish 6 to suspend relative to the ball socket support 5; the main hole (main orifice) 511 provides a main large flow of air to the air gap formed between the spherical culture dish 6 and the ball socket, suspending the spherical culture dish 6.
The auxiliary holes 512 are arranged in a plurality of groups and are distributed around the main hole 511 in a crossed manner, and are used for forming turbulence on the spherical surface of the spherical dish 6 and promoting the spherical dish 6 to rotate randomly; the auxiliary throttling hole provides secondary low-flow air flow on the basis that the main throttling hole forms an air gap between the spherical culture dish and the ball socket, so that the suspension of the suspension spherical culture dish is more stable and stable.
3-4 groups of speed regulation holes 513 are uniformly distributed in the middle upper part of the ball socket, and the speed regulation orifices provide pneumatic flow in random rotation directions to regulate the rotation speed.
The shape of the throttle hole 51 includes but is not limited to a regular pattern, such as a circle, a strip-shaped hole, a special-shaped hole, etc., the size of the air hole is adjustable according to the spherical surface size of the hemispherical support, and the number of the air holes is at least 1.
The digital valve matrix module 4 is provided with digital valves corresponding to the main hole 511, the auxiliary hole 512 and the speed regulation hole 513 one by one, and the digital valves are connected with a control system.
The microcomputer control system 2 controls the duty ratio of each digital valve in the digital valve matrix 4 to adjust the distribution of the gas field from the pneumatic pipeline 52 to the output of the spherical support, so that the spherical culture dish generates suspension spinning motion.
The air supply 3 comprises an air pressure source 31, an air pump 32 and an overflow valve 33 for supplying air to the digital valves.
Spherical (culture) dish 6 specially designed to match the spherical seat: the shell material has the function of allowing gas molecules to pass through but preventing liquid molecules from passing through; the basic shape of the appearance of the product adopts a spherical design, including but not limited to a sphere; the spherical culture dish 6 is designed by adopting a non-integrated structure, including but not limited to two parts; spherical culture dishes and hemispherical supports with a series of sizes can be prepared according to different biological sample requirements.
There are two structural forms:
firstly, the spherical dish 6 is formed by detachably screwing an upper hemispherical shell 61 and a lower hemispherical shell 62.
Secondly, the spherical dish 6 comprises a body and a cover body 63, the cover body 63 is in a spherical crown shape, a hole matched with the shape of the cover body 63 is formed in the body, and the cover body 63 is connected with the hole in the body through a sealing threaded connection structure.
And distance measuring devices 7 are uniformly distributed at the edge of the opening of the spherical bowl support 5 and used for acquiring real-time position information of the spherical vessel 6, and the distance measuring devices 7 are connected with the control system 2.
And limiting protection devices 8 are uniformly distributed at the edge of the ball bowl support 5.
The application of the pneumatic suspension type three-dimensional microgravity biological effect simulation system in biological sample culture is shown in fig. 8-12, the time less than or equal to MRT is taken as a motion period, the random motion track of the biological sample in each motion period is taken as a coordinate system, and the sum of gravity vectors borne by the biological sample in each motion period is zero.
The biological sample requires a certain time to respond to the gravity, and the minimum time is called "minimum action time of gravity response", which is simply called "Minimum Response Time (MRT)". If the time less than or equal to the MRT is taken as a motion period, the biological sample can generate spherical random track motion in each motion period, and the sum of the gravity vectors borne by the biological sample in each motion period is zero by taking the biological sample as a coordinate system, so that the aim of simulating the microgravity biological effect is fulfilled.
It should be noted that the control system 2 of the present invention may be constituted by a microcontroller or an analog circuit, and the control strategy is the core of the unit. The outer wall of the control unit is provided with a display control screen and an operating button. The control system is set and the circuit is formed, and belongs to a relatively mature technical measure in the field; in addition, the adjustment of the air flow and the control of the duty ratio of each digital valve according to the quality of the actual application state of the culture dish 6 belong to the technical means that a person skilled in the art selectively sets the duty ratio according to actual needs, and are not described in detail in the present case.
The invention adopts a microcomputer control system to control a digital micro flow valve matrix to adjust the gas flow field output by the gas guide hole on the inner spherical surface of the hemispherical support. When the gas flow field meets the suspension condition of the spherical culture dish, the spherical culture dish generates stable suspension and random self-spinning motion in the gas flow field by utilizing the randomness generated by fluid turbulence, so that the biological sample in the internal culture solution is driven to generate spherical random track motion in a motion period which is shorter than the minimum gravity response time, and the experimental device capable of performing three-dimensional microgravity biological effect simulation culture on the related biological sample is realized.
The present invention is not limited to the above-mentioned embodiments, and based on the technical solutions disclosed in the present invention, those skilled in the art can make some substitutions and modifications to some technical features without creative efforts according to the disclosed technical contents, and these substitutions and modifications are all within the protection scope of the present invention.
Claims (9)
1. A pneumatic suspension type three-dimensional microgravity biological effect simulation system comprises a box body (1), a control system (2) and an air source (3), and is characterized by further comprising a ball bowl support (5), a digital valve matrix module (4) and a spherical dish (6), wherein the ball bowl support (5) is provided with a ball socket for accommodating the spherical dish (6), and the surface of the ball socket is provided with an orifice (51); the gas source (3) is communicated with the throttling hole (51) through the digital valve matrix module (4) and a pneumatic pipeline (52); the air flow sprayed out of the throttle hole (51) blows against the spherical dish (6) so that the spherical dish (6) is suspended in a ball socket of the ball socket support (5) to perform random rotation movement.
2. The pneumatic suspension type three-dimensional microgravity bioeffect simulation system of claim 1, wherein the orifice (51) on the surface of the ball socket comprises a main hole (511), an auxiliary hole (512) and a speed regulation hole (513);
1 to 5 main holes (511) are uniformly distributed in the middle of the bottom of the ball socket and used for enabling the spherical dish (6) to suspend relative to the spherical bowl support (5);
the auxiliary holes (512) are arranged in a plurality of groups and are distributed around the main hole (511) in a crossed manner, and are used for forming turbulence on the spherical surface of the spherical dish (6) and promoting the spherical dish (6) to rotate randomly;
the speed regulation holes (513) are arranged in 3-4 groups and are uniformly distributed in the middle-upper part of the ball socket and used for providing pneumatic flow in random rotation directions and regulating the rotation speed.
3. The pneumatic suspension type three-dimensional microgravity bioeffect simulation system of claim 2, wherein the digital valve matrix module (4) is provided with digital valves corresponding to the main hole (511), the auxiliary hole (512) and the speed regulation hole (513) one by one, and the digital valves are connected with the control system.
4. The pneumatic suspension type three-dimensional microgravity bioeffect simulation system of claim 3, wherein the air source (3) comprises an air pressure source (31), an air pump (32) and an overflow valve (33) for supplying air to each of the digital valves.
5. The pneumatic suspension type three-dimensional microgravity bioeffect simulation system according to claim 1, wherein the spherical dish (6) is formed by detachably screwing an upper hemispherical shell (61) and a lower hemispherical shell (62).
6. The pneumatic suspension type three-dimensional microgravity biological effect simulation system according to claim 1, wherein the spherical dish (6) comprises a body and a cover body (63), the cover body (63) is in a spherical crown shape, a hole matched with the cover body (63) in shape is formed in the body, and the cover body (63) is connected with the hole in the body through a sealing threaded connection structure.
7. The pneumatic suspension type three-dimensional microgravity bioeffect simulation system of claim 1, wherein distance measuring devices (7) are uniformly distributed at the edge of the ball bowl support (5) for collecting real-time position information of the spherical dish (6), and the distance measuring devices (7) are connected with the control system (2).
8. The pneumatic suspension type three-dimensional microgravity bioeffect simulation system of claim 1, wherein a limiting protection device (8) is uniformly distributed at the opening edge of the ball bowl support (5).
9. The application of the pneumatic suspension type three-dimensional microgravity biological effect simulation system in biological sample culture as claimed in claim 1, wherein the time of MRT or less is taken as a motion period, the random motion track of the biological sample in each motion period takes the biological sample as a coordinate system, and the sum of gravity vectors received in each motion period is zero.
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