CN115193325B - A medicine heating stirring reactor for pharmacology - Google Patents

A medicine heating stirring reactor for pharmacology Download PDF

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Publication number
CN115193325B
CN115193325B CN202211125247.7A CN202211125247A CN115193325B CN 115193325 B CN115193325 B CN 115193325B CN 202211125247 A CN202211125247 A CN 202211125247A CN 115193325 B CN115193325 B CN 115193325B
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stirring
medicine
lifting
wall
conveying
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CN115193325A (en
Inventor
黄鹏
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Foshan Maternal and Child Health Care Hospital
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Foshan Maternal and Child Health Care Hospital
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80Mixing plants; Combinations of mixers
    • B01F33/84Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20Measuring; Control or regulation
    • B01F35/22Control or regulation
    • B01F35/221Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2215Temperature
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75Discharge mechanisms
    • B01F35/754Discharge mechanisms characterised by the means for discharging the components from the mixer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90Heating or cooling systems
    • B01F35/92Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90Heating or cooling systems
    • B01F2035/99Heating
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/2202Mixing compositions or mixers in the medical or veterinary field
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0409Relationships between different variables defining features or parameters of the apparatus or process

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)

Abstract

The invention belongs to the technical field of pharmacological equipment, and particularly provides a drug heating stirring reactor for pharmacology, which comprises orthogonal stirring kettles, transverse row differential conveying mechanisms, longitudinal row differential heating mechanisms and a reaction box, wherein the orthogonal stirring kettles are fixedly arranged on the inner bottom wall of the reaction box in a rectangular array manner, the transverse row differential conveying mechanisms are fixedly arranged on the upper wall of the reaction box in an array manner, and the longitudinal row differential heating mechanisms are fixedly arranged on the side wall of the reaction box in an array manner. The invention provides a plurality of groups of mixing spaces for medicines by using an array arrangement mode, realizes the neutralization of equipment vibration by using a stirring device with a special geometric form and the fluid mechanics characteristic, improves the stirring and mixing efficiency and the equipment durability, and performs bidirectional grouping on the medicine mixing spaces and controls the dosage and the temperature variable by using the orthogonal experiment principle, so that the medicine mixing liquids of all groups are different and mutually related, and the pharmacological material source is enriched.

Description

A medicine heating stirring reactor for pharmacology
Technical Field
The invention belongs to the technical field of pharmacological equipment, and particularly relates to a heating and stirring reactor for a pharmacological medicament.
Background
Pharmacology mainly comprises two aspects of pharmacodynamics and pharmacokinetics, the purpose of pharmacological research is to know the characteristics and rules of the drug action through experiments, theoretical bases are provided for the research and development of new drugs and the evaluation of drugs, the basic principles of pharmacological experiments comprise a contrast principle, a randomization principle and a repetition principle, namely, the pharmacological experiments need to adopt a similar orthogonal experiment mode to carry out contrastive analysis and induction summary on multiple groups of experiments, therefore, in the drug preparation stage, the drug preparation conditions need to be changed to form drugs with different properties, and further, the drug effect and the drug property of the drugs can be contrastively analyzed and evaluated.
In the prior art, the same problem exists in the stirring equipment for pharmacological drugs, that is, only a single-property drug can be prepared in a single drug preparation process, multiple groups of drugs with different properties cannot be prepared simultaneously, and the drugs prepared at different times are affected by the environment and equipment to cause non-uniformity of property change, so that when the drugs with different properties prepared at different times are contrasted and analyzed, the drug effect difference of the drugs is difficult to match with the variable difference during drug preparation, thereby affecting the evaluation of pharmacological analysts on the drug effect and drug property of the drugs.
Disclosure of Invention
According to the technical problems, the invention provides a medicine heating and stirring reactor for pharmacology, which aims at the technical problems that a plurality of groups of medicines with different properties cannot be prepared simultaneously in the prior art, and the medicine effect difference of the medicines is difficult to match with the variable difference during medicine preparation.
The technical scheme adopted by the invention is as follows: the scheme provides a medicine heating stirring reactor for pharmacology, which comprises an orthogonal stirring kettle, a transverse row differential material conveying mechanism, a longitudinal row differential heating mechanism and a reaction box, wherein the rectangular array of the orthogonal stirring kettle is fixedly distributed on the bottom wall inside the reaction box, the transverse row differential material conveying mechanism is fixedly distributed on the upper wall of the reaction box in an equidistant array manner, the longitudinal row differential heating mechanism is fixedly distributed on the side wall of the reaction box in an equidistant array manner, the upper end of the orthogonal stirring kettle on one transverse row is respectively communicated and connected with the lower wall of one transverse row differential material conveying mechanism, the lower wall of the orthogonal stirring kettle on one longitudinal row is respectively fixedly connected with the upper wall of one longitudinal row differential heating mechanism, a single-source lifting liquid flow balanced stirring component is arranged on the lower wall of the orthogonal stirring kettle, the single-source lifting liquid flow balanced stirring component comprises a single-source lifting self-discharging shaft and a single-source reciprocating stirring motor, the single-source lifting stirring self-discharging shaft is slidably penetrated and arranged on the lower wall of the orthogonal stirring kettle, the upper end of the single-source lifting stirring shaft is arranged inside the orthogonal stirring kettle, and the lower wall of the single-lifting stirring kettle is arranged outside the orthogonal stirring kettle.
Furthermore, a material conveying pipe is fixedly arranged on the upper wall of the orthogonal stirring kettle in a penetrating mode, a stirring discharge pipe is fixedly arranged on the lower wall of the orthogonal stirring kettle in a penetrating mode, and the single-source lifting stirring device is closely attached to the circumferential side wall of the discharge shaft and the inner side wall of the stirring discharge pipe in a sliding mode.
Further, a liquid drainage hollow cavity is arranged in the single-source lifting stirring self-discharging shaft in a penetrating mode along the axis, a solenoid valve is fixedly arranged in the liquid drainage hollow cavity, stirring blades are fixedly arranged on the upper end of the single-source lifting stirring self-discharging shaft in an annular array mode, the stirring blades are arranged in an inclined mode, liquid drainage holes are symmetrically arranged in the upper edge of the side wall of the single-source lifting stirring self-discharging shaft in a penetrating mode, the liquid drainage holes and the liquid drainage hollow cavity are arranged in a penetrating mode, a lifting power ring is rotatably clamped in the middle of the side wall of the circumference of the single-source lifting stirring self-discharging shaft and arranged below a stirring and discharging pipe, a stirring driven long gear is fixedly arranged on the side wall of the circumference of the single-source lifting stirring self-discharging shaft and arranged below the lifting power ring; the inclination direction of the stirring blades is that the rear part of any section motion direction of the stirring blades is lower than the front part.
Further, a stirring power gear is coaxially and fixedly arranged at the output end of the single-source reciprocating stirring motor, the stirring power gear is meshed with the stirring driven long gear, a lifting power disc is arranged on the edge of the upper wall of the stirring power gear in a rotating mode, a lifting power lug plate is fixedly arranged on the upper wall of the lifting power disc, a lifting driven plate is fixedly arranged on the side wall of the lifting power ring, a lifting driven disc is arranged on the lower wall of the lifting driven plate in a rotating mode, a lifting driven lug plate is fixedly arranged on the lower wall of the lifting driven disc, a lifting power rod is arranged on the upper wall of the stirring power gear, and the upper end and the lower end of the lifting power rod are respectively connected with the lifting driven lug plate and the lifting power lug plate in a rotating mode.
Further, horizontal row differentiation defeated material mechanism includes the defeated medicine material line, horizontal row quantitative conveyer and conveying leading truck, defeated medicine material line array distributes and runs through fixed locating the reaction box upper wall, horizontal row quantitative conveyer array distributes and locates the inside lateral wall of reaction box, conveying leading truck array distributes and fixes respectively and locates the quadrature stirred tank upper end, defeated medicine material line and horizontal row quantitative conveyer top-down one-to-one set up, one of them horizontal row quantitative conveyer slides and runs through the conveying leading truck lateral wall setting in the horizontal row at its place.
Further, the horizontal quantitative conveying device comprises a conveying electric push rod and a conveying connecting block, the conveying electric push rod is fixedly arranged on the inner side wall of the reaction box, the conveying connecting block is distributed in an array mode and penetrates through the side wall of the conveying guide frame in a sliding mode respectively, a conveying connecting rod is fixedly arranged between every two adjacent conveying connecting blocks on one horizontal row respectively, two ends of each conveying connecting rod are fixedly connected with the side walls of the adjacent conveying connecting blocks respectively, the side wall of the conveying connecting block closest to the conveying electric push rod is fixedly connected with the output end of the conveying electric push rod, each conveying connecting block comprises a leakage-proof check block, a quantitative conveying square pipe and a stirring sealing block, the leakage-proof check blocks, the quantitative conveying square pipes and the stirring sealing blocks are sequentially and fixedly connected along the horizontal direction distribution of the extension of the conveying electric push rod, the inner volume of the quantitative conveying square pipes on the same horizontal quantitative conveying device is the same, and the inner volume of the quantitative conveying square pipes on the adjacent horizontal conveying devices is different; the inside quantitative transfer side of single horizontal row pipe has the same volume, can convey equivalent medicine, and the volume is different in the quantitative transfer side of different horizontal rows between to can carry out the dose differentiation to the medicine and convey, form a plurality of doses and divide into groups, each internal medicine volume is the same, the dose is different between each group.
Further, the conveying guide frame comprises a sliding guide pipe and a plugging medicine discharging plate, the plugging medicine discharging plate is distributed in an array mode and is fixedly arranged at the upper end of the conveying pipe respectively, the sliding guide pipe is distributed in an array mode and is fixedly arranged on the upper wall of the plugging medicine discharging plate respectively, a feeding hole is formed in the upper wall of the plugging medicine discharging plate in a penetrating mode and is arranged above the conveying pipe, the conveying connecting block slides respectively to penetrate through the side wall of the sliding guide pipe, and the lower wall of the conveying connecting block slides respectively to be closely attached to the upper wall of the plugging medicine discharging plate.
Further, the medicine conveying line level sets up, and medicine conveying line upper wall middle part is run through fixedly and is equipped with and adds the medicine box, and it runs through the setting of reaction box upper wall to add the medicine box, and medicine conveying line lower wall array distributes and runs through fixedly and is equipped with the side pipe of putting the medicine, put the side pipe wall down along with slide guide pipe lateral wall on along corresponding fixed connection, the conveying allies oneself with the piece upper wall and slides closely with the side pipe lower wall of putting the medicine respectively.
Furthermore, the longitudinal differentiated heating mechanism comprises heating controllers and heating plates, the heating controllers are fixedly arranged on the side walls of the reaction box in a penetrating manner respectively, the heating plates are fixedly arranged on the lower walls of the orthogonal stirring kettles respectively, the upper wall of one heating plate is fixedly connected with the lower wall of one longitudinal orthogonal stirring kettle, the side walls of the heating controllers are fixedly connected with the side walls at the end parts of the heating plates respectively, the side walls of the heating controllers are rotatably provided with temperature control buttons, the upper walls of the heating plates are fixedly distributed and provided with heating pieces in an array manner, the heating pieces are fixedly connected with the lower walls of the orthogonal stirring kettles respectively, and the heating pieces are electrically connected with the heating controllers respectively; any temperature control button controls the heating plates on the heating plates corresponding to the temperature control buttons to be heated to the same temperature and heats orthogonal stirring kettles in the same column, the temperatures generated by the orthogonal stirring kettles in different columns are different when the rotation angles of the temperature control buttons on different heating controllers are different, the heating controllers enable the orthogonal stirring kettles to be heated to a plurality of groups of reaction temperatures, the internal temperatures of the same column are the same, and the temperatures of different columns are different.
Furthermore, the lower wall array inside the reaction box is fixedly provided with recovery boxes, the recovery boxes are respectively arranged below the single-source lifting stirring shaft, the single-source lifting stirring shaft is arranged on the inner wall of the recovery box along the lower edge of the circumferential side wall of the discharge shaft in a sliding manner, the lower wall array of the reaction box is fixedly provided with discharge pipe heads, and the discharge pipe heads are in one-to-one through connection with the lower wall of the recovery box through pipelines.
The invention with the structure has the following beneficial effects:
(1) The orthogonal stirring kettle provides a plurality of groups of mixing spaces for the medicines in a rectangular array mode, multi-directional stirring and mixing of medicine mixed liquid are realized by utilizing the versatility of a single power source, and meanwhile, the neutralization of equipment vibration is realized by means of stirring devices in special geometric forms and the fluid mechanics characteristic, so that the stirring and mixing efficiency is improved, and the durability of the equipment is improved;
(2) The horizontal row differential conveying mechanism and the vertical column differential heating mechanism divide the orthogonal stirring kettles into a plurality of horizontal rows and a plurality of vertical columns respectively, and the dosage and temperature variable control is carried out on the orthogonal stirring kettles of each horizontal row and each vertical column by using an orthogonal experiment principle, so that the medicine mixed liquids in the orthogonal stirring kettles are different from each other and are mutually associated, and the material sources of pharmacological experiments are remarkably enriched;
(3) The single-source lifting stirring self-discharging shaft forms a hollow shape by virtue of a liquid discharging hollow cavity which penetrates through the shaft line, so that the stirring power output function and the medicine mixed liquid discharging function are integrated, and the structural complexity of the orthogonal stirring kettle is reduced;
(4) The stirring blades are arranged in an inclined mode that the rear part of any section motion direction is lower than the front part of any section motion direction, so that the resistance of the medicine mixed liquid to the stirring blades is different in the processes of rotating up and rotating down, namely the resistance borne by the stirring blades can act together with the gravity of the single-source lifting stirring self-discharging shaft, the load borne by the lifting power rod in the process of driving the single-source lifting stirring self-discharging shaft to lift is balanced, and the equipment is prevented from generating large-amplitude vibration and being damaged by impact;
(5) The single-source reciprocating stirring motor provides rotary power for the single-source lifting stirring self-discharging shaft by means of the meshing of the stirring power gear and the stirring driven long gear, and provides lifting power for the single-source lifting stirring self-discharging shaft by means of the interaction of the lifting power rod and the lifting power ring, so that the device can fully stir the medicine mixed liquid under the condition of a single power source;
(6) The horizontal row differential conveying mechanism conveys medicine dry powder to the orthogonal stirring kettles of each horizontal row by virtue of a medicine conveying material line, quantitative conveying square pipes in a single horizontal row have the same volume and can convey the same amount of medicine, and the quantitative conveying square pipes in different horizontal rows have different volumes, so that medicine quantity differential conveying can be carried out on the medicine, a plurality of medicine quantity groups are formed, and further the medicine quantity in each group of the orthogonal stirring kettles is the same, and the medicine quantity in each group is different;
(7) The column differential heating mechanism controls the temperature of the orthogonal stirred tanks by means of independently controlled heating controllers, the orthogonal stirred tanks in the same column are on the same heating plate, so the temperature is the same, the temperature control buttons on different heating controllers have different rotating angles, the temperatures generated by the orthogonal stirred tanks in different columns are different, the internal temperatures of the orthogonal stirred tanks in the same column are the same, and the temperatures of the orthogonal stirred tanks in different columns are different;
(8) The horizontal quantitative conveying device controls the dosage and blocks the stirring process, during the process of adding and conveying medicines, the lower end of each medicine placing tube is blocked by each leak-proof stop block, the medicines in the medicine placing tubes are prevented from leaking, after the medicines are added, the feeding ports are blocked by the stirring block blocks, the medicine mixed liquid is prevented from splashing out of the device during the stirring process, the medicine waste is reduced, and the heating mixed liquid is prevented from being dangerous.
Drawings
FIG. 1 is a schematic structural view of a heated stirred reactor for pharmacological drugs according to the present invention;
FIG. 2 is a schematic structural view of an orthogonal stirring kettle, a horizontal differential conveying mechanism and a vertical differential heating mechanism according to the present invention;
FIG. 3 is a schematic structural view of an orthogonal stirred tank according to the present invention;
FIG. 4 is a schematic structural diagram of a single-source lift-type liquid flow balanced stirring assembly according to the present invention;
FIG. 5 is a schematic view of a single-source lifting stirring self-discharging shaft according to the present invention;
FIG. 6 is a side cross-sectional view of a single source elevating agitator self-bleeding shaft according to the present invention;
FIG. 7 is a partial enlarged view of portion A of FIG. 4;
FIG. 8 is a partial enlarged view of portion B of FIG. 5;
FIG. 9 is a schematic view of a disassembled structure of the horizontal differential feeding mechanism of the present invention;
FIG. 10 is a schematic structural view of a lateral quantitative transfer device according to the present invention;
fig. 11 is a schematic structural diagram of a column-based differential heating mechanism according to the present invention.
Wherein, 1, an orthogonal stirring kettle, 11, a single-source lifting liquid flow balance type stirring component, 111, a single-source lifting stirring self-discharging shaft, 1111, a liquid discharging hollow cavity, 1112, an electromagnetic valve, 1113, a stirring blade, 1114, a liquid discharging hole, 1115, a lifting power ring, 1116, a stirring driven long gear, 1117, a lifting driven plate, 1118, a lifting driven plate, 1119, a lifting driven lug plate, 112, a single-source reciprocating stirring motor, 1121, a stirring power gear, 1122, a lifting power plate, 1123, a lifting power lug plate, 1124, a lifting power rod, 12, a material conveying pipe, 13 and a stirring discharging pipe, 2, horizontal row differentiation conveying mechanism, 21, medicine conveying material line, 211, add the medicine box, 212, put medicine side's pipe, 22, horizontal row ration conveyer, 221, transmission push rod, 222, transmission link block, 2221, transmission connecting rod, 2222, leak protection dog, 2223, ration transmission side's pipe, 2224, stirring shutoff piece, 23, transmission leading truck, 231, sliding guide pipe, 232, shutoff medicine board, 2321, pan feeding mouth, 3, vertical row differentiation heating mechanism, 31, heating controller, 311, temperature control button, 32, hot plate, 321, heating plate, 4, reaction box, 41, collection box, 42, blowing tube head.
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments; all other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings, merely for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention.
The embodiment is as follows:
referring to fig. 1-4, in this embodiment, a drug heating and stirring reactor for pharmacology includes an orthogonal stirring tank 1, horizontal row differentiated feeding mechanisms 2, vertical row differentiated heating mechanisms 3 and a reaction tank 4, the orthogonal stirring tank 1 is fixedly disposed on the bottom wall inside the reaction tank 4 in a rectangular array distribution, the horizontal row differentiated feeding mechanisms 2 are fixedly disposed on the upper wall of the reaction tank 4 in an equidistant array distribution, the vertical row differentiated heating mechanisms 3 are fixedly disposed on the side wall of the reaction tank 4 in an equidistant array distribution, the upper end of the orthogonal stirring tank 1 on one horizontal row is respectively connected to the lower wall of one of the horizontal row differentiated feeding mechanisms 2 in a through manner, the lower wall of the orthogonal stirring tank 1 on one vertical row is respectively fixedly connected to the upper wall of one of the vertical row differentiated heating mechanisms 3, the lower wall of the orthogonal stirring tank 1 is provided with a single-source lifting liquid flow balanced stirring assembly 11, the single-source lifting liquid flow balanced stirring assembly 11 includes a single-source lifting and stirring self-discharging shaft 111 and a single-source reciprocating stirring motor 112, the single-source lifting and stirring shaft 111 is slidably disposed on the orthogonal stirring tank 1, the lower wall of the orthogonal stirring tank 1, the single-source lifting and the single-discharging shaft 111 is disposed on the lower end of the orthogonal stirring tank 1, the lower wall of the orthogonal stirring tank 1, the single-lifting and the single-source lifting stirring shaft 111 is disposed on the lower wall of the orthogonal stirring tank 1, the single-lifting and the single-lifting stirring shaft 111, the single-lifting and the single-lifting stirring shaft 112.
Referring to FIG. 3, in this embodiment, a material feeding pipe 12 is fixedly penetrated through the upper wall of the orthogonal stirring tank 1, a stirring discharging pipe 13 is fixedly penetrated through the lower wall of the orthogonal stirring tank 1, and the single-source lifting stirring is closely attached to the circumferential side wall of the discharging shaft 111 and the inner side wall of the stirring discharging pipe 13 in a sliding manner.
Referring to fig. 5 and 6, in the present embodiment, a liquid drainage hollow cavity 1111 is formed in the single-source lifting stirring self-discharging shaft 111 in a penetrating manner along the axis, an electromagnetic valve 1112 is fixedly disposed in the liquid drainage hollow cavity 1111, stirring blades 1113 are fixedly disposed in the single-source lifting stirring self-discharging shaft 111 in an annular array manner, the stirring blades 1113 are obliquely disposed, liquid drainage holes 1114 are symmetrically formed in the upper edge of the side wall of the single-source lifting stirring self-discharging shaft 111 in a penetrating manner, the liquid drainage holes 1114 and the liquid drainage hollow cavity 1111 are arranged in a penetrating manner, a lifting power ring 1115 is rotatably and snap-connected to the middle portion of the circumferential side wall of the single-source lifting stirring self-discharging shaft 111, the lifting power ring 1115 is disposed below the stirring discharge pipe 13, a stirring driven long gear 1116 is fixedly disposed on the circumferential side wall of the single-source lifting stirring self-discharging shaft 111, and the stirring driven long gear 1116 is disposed below the lifting power ring 1115; the inclination direction of the stirring blades 1113 is such that the rear of any cross-sectional movement direction of the stirring blades 1113 is lower than the front.
Referring to fig. 7 and 8, in the present embodiment, an output end of the single-source reciprocating stirring motor 112 is coaxially and fixedly provided with a stirring power gear 1121, the stirring power gear 1121 is engaged with the stirring driven long gear 1116, an edge of an upper wall of the stirring power gear 1121 is rotatably provided with a lifting power disc 1122, an upper wall of the lifting power disc 1122 is fixedly provided with a lifting power lug 1123, a side wall of the lifting power ring 1115 is fixedly provided with a lifting driven plate 1117, a lower wall of the lifting driven plate 1117 is rotatably provided with a lifting driven disc 1118, a lower wall of the lifting driven disc 1118 is fixedly provided with a lifting driven lug 1119, an upper wall of the stirring power gear 1121 is provided with a lifting power rod 1124, and upper and lower ends of the lifting power rod 1124 are rotatably connected with the lifting driven lug 1119 and the lifting power lug 1123, respectively.
Referring to fig. 2, in the present embodiment, the horizontal differentiated feeding mechanism 2 includes a drug conveying line 21, horizontal quantitative conveyors 22 and a conveying guide frame 23, the drug conveying line 21 is arranged in an array to penetrate through and fixed on the upper wall of the reaction box 4, the horizontal quantitative conveyors 22 are arranged in an array to be arranged on the inner side wall of the reaction box 4, the conveying guide frames 23 are arranged in an array to be fixed on the upper end of the orthogonal stirring kettle 1, the drug conveying line 21 and the horizontal quantitative conveyors 22 are arranged in a one-to-one correspondence from top to bottom, and one of the horizontal quantitative conveyors 22 is arranged to penetrate through the side wall of the conveying guide frame 23 in the horizontal row where the horizontal quantitative conveyor 22 is located.
Referring to fig. 9 and 10, in the present embodiment, the transverse quantitative transfer device 22 includes a transfer electric push rod 221 and a transfer link 222, the transfer electric push rod 221 is fixedly disposed on the inner side wall of the reaction chamber 4, the transfer link 222 is distributed in an array and respectively slidably disposed on the side walls of the transfer guide frame 23, a transfer link 2221 is fixedly disposed between adjacent transfer links 222 on one transverse row, two ends of the transfer link 2221 are respectively fixedly connected to the side walls of the adjacent transfer links 222, the side wall of the transfer link 222 closest to the transfer electric push rod 221 is fixedly connected to the output end of the transfer electric push rod 221, the transfer link 222 includes a leakage-proof block 2222, a quantitative transfer square tube 2223 and a stirring block 2224, the leakage-proof block 2222, the quantitative transfer square tube 2223 and the stirring block 2224 are sequentially and fixedly connected along the horizontal direction of the extension of the transfer electric push rod 221, the internal volumes of the quantitative transfer square tubes 2223 on the same transverse quantitative transfer device 22 are the same, and the volumes of the internal volumes of the quantitative transfer square tubes 2223 on the adjacent transverse quantitative transfer devices 22 are different; the inside quantitative transfer side pipe 2223 of single horizontal row has the same volume, can transmit equivalent medicine, and the quantitative transfer side pipe 2223 volume between the different horizontal rows is different to can carry out the dose differentiation to the medicine and transmit, form a plurality of dose groups, the dose is the same in each group, the dose is different between each group.
Referring to fig. 9, in the present embodiment, the conveying guide frame 23 includes sliding guide tubes 231 and blocking and medicine-discharging plates 232, the blocking and medicine-discharging plates 232 are respectively and fixedly arranged at the upper ends of the conveying tubes 12 in an array, the sliding guide tubes 231 are respectively and fixedly arranged on the upper walls of the blocking and medicine-discharging plates 232 in an array, the upper walls of the blocking and medicine-discharging plates 232 are provided with material inlets 2321 in a penetrating manner, the material inlets 2321 are arranged above the conveying tubes 12, the conveying linking blocks 222 are respectively and slidably arranged through the side walls of the sliding guide tubes 231, and the lower walls of the conveying linking blocks 222 are respectively and closely attached to the upper walls of the blocking and medicine-discharging plates 232 in a sliding manner.
Referring to fig. 9, in the present embodiment, the drug delivery line 21 is horizontally disposed, the drug adding boxes 211 are fixedly disposed in the middle of the upper wall of the drug delivery line 21, the drug adding boxes 211 are disposed in the upper wall of the reaction box 4, the drug discharging square tubes 212 are fixedly disposed in the lower wall of the drug delivery line 21 in an array manner, the lower edges of the lateral walls of the drug discharging square tubes 212 are fixedly connected with the upper edges of the lateral walls of the sliding guide tubes 231, and the upper walls of the conveying connection blocks 222 are respectively closely attached to the lower walls of the drug discharging square tubes 212 in a sliding manner.
Referring to fig. 2 and 11, in this embodiment, the column differentiation heating mechanism 3 includes a heating controller 31 and heating plates 32, the heating controller 31 is respectively fixedly penetrated through the side walls of the reaction box 4, the heating plates 32 are respectively fixedly arranged on the lower walls of the orthogonal stirred tanks 1, the upper wall of one heating plate 32 is fixedly connected with the lower wall of one column of orthogonal stirred tanks 1, the side walls of the heating controller 31 are respectively fixedly connected with the side walls of the end portions of the heating plates 32, the side walls of the heating controller 31 are rotatably provided with temperature control buttons 311, the upper walls of the heating plates 32 are respectively and fixedly distributed with heating sheets 321, the heating sheets 321 are respectively and fixedly connected with the lower walls of the orthogonal stirred tanks 1, and the heating sheets 321 are respectively and electrically connected with the heating controller 31, in this embodiment, the heating controller 31 is preferably a tqiidec-TEA-2001 pointer temperature control instrument; any temperature control button 311 controls the heating plate 321 on the corresponding heating plate 32 to rise to the same temperature and heat the orthogonal stirred tanks 1 in the same column, when the rotation angles of the temperature control buttons 311 on different heating controllers 31 are different, the temperatures generated by the orthogonal stirred tanks 1 in different columns are different, the heating controller 31 enables the orthogonal stirred tanks 1 to rise to a plurality of groups of reaction temperatures, the internal temperatures of the same column are the same, and the temperatures of different columns are different.
Referring to fig. 1, in the present embodiment, the recycling boxes 41 are fixedly arranged in the lower wall array inside the reaction box 4, the recycling boxes 41 are respectively arranged below the single-source lifting stirring self-discharging shaft 111, the single-source lifting stirring self-discharging shaft 111 is slidably arranged on the inner wall of the recycling box 41 along the lower edge of the circumferential side wall, the discharging tube heads 42 are fixedly arranged in the lower wall array of the reaction box 4, and the discharging tube heads 42 are connected with the lower wall of the recycling boxes 41 through the pipelines one by one.
The implementation principle of the embodiment is as follows: the method comprises the steps of stirring medicine mixed liquid by orthogonal stirring kettles 1 distributed in an array mode, grouping the orthogonal stirring kettles 1 by means of horizontal row differential conveying mechanisms 2 with different medicine conveying amounts, enabling the orthogonal stirring kettles 1 to be divided into a plurality of horizontal rows, utilizing the characteristic that the single horizontal row differential conveying mechanism 2 is used for enabling the medicine conveying amounts of the orthogonal stirring kettles 1 below the single horizontal row differential conveying mechanism 2 to be the same, enabling the medicine amounts of the orthogonal stirring kettles 1 in any horizontal row to be the same and enabling the medicine amounts of different horizontal rows to be different, grouping the orthogonal stirring kettles 1 by means of independently controlled vertical row differential heating mechanisms 3, enabling the orthogonal stirring kettles 1 to be divided into a plurality of vertical rows, enabling the medicine amount and the stirring temperature of each orthogonal stirring kettle 1 to be different in a vertical and horizontal control variable mode, and accordingly providing various experimental samples for pharmacological experiments.
The specific implementation manner of this embodiment is:
before preparing the medicine mixture, firstly, the medicine dry powder is respectively placed in each medicine adding box 211, the medicine dry powder falls into the medicine conveying line 21 under the action of gravity, in the initial state, the electromagnetic valve 1112 is in a closed state, the transmission electric push rod 221 is in a contraction state, at the moment, the quantitative transmission square tube 2223 is respectively positioned right below the medicine placing square tube 212, the stirring and blocking block 2224 is respectively positioned inside the sliding guide tube 231 and blocks the blocking and medicine placing plate 232, so that the inside of the orthogonal stirring kettle 1 is in a closed state, and the equal and homogeneous medicine mixture is stored inside the orthogonal stirring kettle 1.
The transverse arrangement differentiated feeding mechanism 2 operates and performs differentiated feeding on each orthogonal stirring kettle 1, the medicine conveying line 21 operates synchronously, the medicine conveying line 21 drives medicine dry powder inside the medicine conveying line to move and fall into each medicine discharging square tube 212 respectively, the medicine dry powder falls into each quantitative conveying square tube 2223 under the action of gravity, the medicine inside the quantitative conveying square tube 2223 is stably stored inside the quantitative conveying square tube 2223 due to the blocking of the blocking medicine discharging plate 232, the medicine storing amount of each medicine discharging square tube 212 and the quantitative conveying square tube 2223 by the medicine conveying line 21 is the same, the medicine storing amount of the medicine conveying square tube 2223 corresponding to the same medicine conveying line 21 is different due to the different volumes of the quantitative conveying square tubes 2223 on the transverse arrangement quantitative conveying device 22, the medicine storing amount is different due to the difference of the different volumes of the medicine conveying square tubes, the medicine adding amount added into the medicine adding kettle 211 is enough for use, the medicine conveying line 21 stops operating, at the moment, the medicine conveying amount of the medicine inside each quantitative conveying square tube 2223 reaches the same, the quantitative conveying square tube 2223 reaches the preset value, the quantitative conveying square tube 2223 is started, the medicine adding rod 2223 slides to drive the medicine discharging square tube 2223 to slide to drive the medicine discharging rod 2221 to slide to drive the medicine discharging square tube 2223 to slide to move towards the lower end of the medicine discharging square tube 2221, the medicine discharging square tube 2223, the medicine discharging square tube 2221, the medicine leaking block, the medicine discharging square tube 2223, the medicine leaking block, the medicine discharging square tube 2223, the medicine leaking block 222, the medicine discharging square tube 2223, the medicine discharging square tube 2221, the medicine leaking block is pushed to slide, the medicine discharging square tube 2223, the medicine leaking block, the medicine discharging square tube 2223, the medicine leaking from the medicine discharging tube 2223, the medicine discharging tube 2221, the medicine leaking from the square tube 2223, the medicine leaking block, the medicine leaking side tube 2223, the medicine leaking from the medicine is prevented from the medicine discharging tube 2221, the transmission push rod 221 is synchronously contracted and reset, and after the transmission link block 222 is reset, the stirring blocking block 2224 blocks the feeding port 2321 to prevent the medicine mixed liquid from splashing out of the device in the stirring process.
An operator controls each heating controller 31 by rotating the temperature control button 311, and further controls the heating plates 321 on each heating plate 32, so that the orthogonal stirring kettles 1 in each column are heated to different temperatures, the temperature of the orthogonal stirring kettles 1 in the same column is the same, the temperature of the orthogonal stirring kettles 1 in different columns is different, when the medicine is mixed and stirred, the single-source reciprocating stirring motor 112 synchronously operates, the single-source reciprocating stirring motor 112 drives the stirring power gear 1121 to rotate, the stirring power gear 1121 drives the single-source lifting stirring self-discharging shaft 111 to rotate along the inner wall of the stirring and discharging pipe 13 through the stirring driven long gear 1116, meanwhile, the stirring power gear 1121 drives the lifting power disc 1122 to move, the lifting power disc 1122 makes the lifting power ring 1115 generate reciprocating lifting and descending through the linkage action of the lifting power rod 1124, so that the single-source lifting stirring self-discharging shaft 111 generates the motion effects of rotating and reciprocating, the single-source lifting stirring self-discharging shaft 111 drives the stirring blade 1113 to reciprocate in the orthogonal stirring kettle 1 and stir the medicine mixed liquid in the orthogonal stirring kettle 1, because the inclination direction of the stirring blade 1113 is that the rear part of any section motion direction of the stirring blade 1113 is lower than the front part, the resistance of the medicine mixed liquid to the stirring blade 1113 is upward and changes along with the increase of the stirring speed, when the stirring blade 1113 rotates and ascends, the resistance of the medicine mixed liquid to the stirring blade 1113 is smaller because of the ascending motion of the stirring blade 1113, when the stirring blade 1113 rotates and descends, the resistance of the medicine mixed liquid to the stirring blade 1113 is larger, namely, the resistance borne by the stirring blade 1113 can jointly act with the gravity of the single-source lifting stirring self-discharging shaft 111, so that the lifting power rod 1124 can bear balanced load in the process of driving the single-source lifting stirring self-discharging shaft 111 to lift, the equipment is prevented from generating large vibration and being damaged by impact, and in the stirring and mixing process, the heating plates 32 heat the medicine mixed liquid in the orthogonal stirring kettles 1 in each vertical row in the same and different vertical rows.
After the medicines are stirred and mixed, the electromagnetic valves 1112 are synchronously powered on and opened, the medicine mixed liquid in each orthogonal stirring kettle 1 respectively enters the liquid drainage hollow cavity 1111 from the liquid drainage holes 1114 on the side wall of the drainage shaft 111 through each single-source lifting stirring and flows into each recovery box 41 under the action of gravity, and an operator collects each group of medicine mixed liquid through the material drainage pipe head 42.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
The present invention and its embodiments have been described above, and the description is not intended to be limiting, and the drawings are only one embodiment of the present invention, and the actual structure is not limited thereto. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (7)

1. The utility model provides a medicine heating stirring reactor for pharmacology, includes quadrature stirred tank (1), horizontal row differentiation defeated material mechanism (2), tandem differentiation heating mechanism (3) and reaction box (4), its characterized in that: the orthogonal stirring kettles (1) are fixedly arranged on the bottom wall in the reaction box (4) in a rectangular array distribution manner, the transverse row differential conveying mechanisms (2) are fixedly arranged on the upper wall of the reaction box (4) in an equidistant array distribution manner, the longitudinal row differential heating mechanisms (3) are fixedly arranged on the side wall of the reaction box (4) in an equidistant array distribution manner, the upper end of the orthogonal stirring kettle (1) on one transverse row is respectively communicated with the lower wall of one of the transverse row differential conveying mechanisms (2), the lower wall of the orthogonal stirring kettle (1) on one longitudinal row is respectively fixedly connected with the upper wall of one of the longitudinal row differential heating mechanisms (3), the lower wall of the orthogonal stirring kettle (1) is provided with a single-source lifting liquid flow balanced stirring assembly (11), the single-source lifting liquid flow balanced stirring assembly (11) comprises a single-source lifting self-discharging stirring shaft (111) and a single-source reciprocating stirring motor (112), the single-source lifting stirring self-discharging shaft (111) is slidably arranged on the orthogonal stirring kettle (1) in a penetrating manner, the lower end of the single-source lifting stirring kettle (111) is fixedly arranged on the inner wall of the orthogonal stirring kettle (1), and the orthogonal stirring kettle (1) is arranged on the lower wall of the single-lifting stirring kettle (111);
a material conveying pipe (12) penetrates through and is fixedly arranged on the upper wall of the orthogonal stirring kettle (1), a stirring and discharging pipe (13) penetrates through and is fixedly arranged on the lower wall of the orthogonal stirring kettle (1), and the circumferential side wall of the single-source lifting stirring self-discharging shaft (111) and the inner side wall of the stirring and discharging pipe (13) are closely attached in a sliding manner;
the single-source lifting stirring self-discharging shaft is characterized in that a liquid discharging hollow cavity (1111) penetrates through the interior of the single-source lifting stirring self-discharging shaft (111) along the axis, electromagnetic valves (1112) are fixedly arranged in the liquid discharging hollow cavity (1111), stirring blades (1113) are fixedly distributed at the upper end of the single-source lifting stirring self-discharging shaft (111) in an annular array manner and are obliquely arranged, liquid discharging holes (1114) symmetrically penetrate through the upper edge of the side wall of the single-source lifting stirring self-discharging shaft (111), the liquid discharging holes (1114) and the liquid discharging hollow cavity (1111) are arranged in a penetrating manner, a lifting power ring (1115) is rotatably clamped in the middle of the circumferential side wall of the single-source lifting stirring self-discharging shaft (111), the lifting power ring (1115) is arranged below the stirring discharging pipe (13), a stirring driven long gear (1116) is fixedly arranged on the circumferential side wall of the single-source lifting stirring self-discharging shaft (111), and the stirring driven long gear (1116) is arranged below the lifting power ring (1116);
the single-source reciprocating stirring device is characterized in that a stirring power gear (1121) is coaxially and fixedly arranged at the output end of the single-source reciprocating stirring motor (112), the stirring power gear (1121) is meshed with a stirring driven long gear (1116), a lifting power disc (1122) is rotationally arranged on the edge of the upper wall of the stirring power gear (1121), a lifting power lug plate (1123) is fixedly arranged on the upper wall of the lifting power disc (1122), a lifting driven plate (1117) is fixedly arranged on the side wall of a lifting power ring (1115), a lifting driven disc (1118) is rotationally arranged on the lower wall of the lifting driven plate (1117), a lifting driven lug plate (1119) is fixedly arranged on the lower wall of the lifting driven disc (1118), a lifting power rod (1124) is arranged on the upper wall of the stirring power gear (1121), and the upper end and the lower end of the lifting power rod (1124) are rotationally connected with the lifting driven lug plate (1119) and the lifting power lug plate (1123) respectively.
2. A heated stirred reactor vessel for pharmacological agents according to claim 1, wherein: horizontal row differentiation is defeated material mechanism (2) is including defeated medicine stockline (21), horizontal row quantitative conveyer (22) and conveying leading truck (23), defeated medicine stockline (21) array distribution runs through fixed locating reaction box (4) upper wall, horizontal row quantitative conveyer (22) array distribution locates the inside lateral wall of reaction box (4), conveying leading truck (23) array distribution is fixed respectively and is located quadrature stirred tank (1) upper end, defeated medicine stockline (21) and horizontal row quantitative conveyer (22) top-down one-to-one setting, one of them horizontal row quantitative conveyer (22) slide and run through conveying leading truck (23) lateral wall setting in the horizontal row at its place.
3. A heated stirred reactor vessel for pharmacological agents according to claim 2, wherein: horizontal quantitative transfer device (22) is including transmitting electric push rod (221) and transmission link piece (222), transmission electric push rod (221) is fixed to be located reaction box (4) inside wall, transmission link piece (222) array distribution slides respectively and runs through and locates transmission leading truck (23) lateral wall, and one of them is adjacent on horizontal row fixed transfer connecting rod (2221) that is equipped with between transmission link piece (222) respectively, transfer connecting rod (2221) both ends respectively with adjacent transmission link piece (222) lateral wall fixed connection, be closest to transmission electric push rod (221) transmission link piece (222) lateral wall and transmission electric push rod (221) output fixed connection, transmission link piece (222) are including leak protection dog (2222), quantitative transmission square pipe (2223) and stirring shutoff block (2224), leak protection square pipe (2222), quantitative transmission square pipe (2223) and stirring shutoff block (2224) distribute fixed connection in proper order along the horizontal direction of transmission electric push rod (221) extension, the same volume of the inside volume transmission square pipe (2223) on the horizontal row quantitative transfer device (22).
4. A heated stirred reactor vessel for pharmacological agents according to claim 3, wherein: conveying leading truck (23) is including sliding guide pipe (231) and shutoff medicine board (232), medicine board (232) are put in the shutoff fixed locating conveying pipeline (12) upper end respectively to the shutoff, sliding guide pipe (231) array distribution is fixed locating the shutoff respectively and is put medicine board (232) upper wall, medicine board (232) upper wall is put in the shutoff and runs through and be equipped with pan feeding mouth (2321), conveying pipeline (12) top is located in pan feeding mouth (2321), conveying link block (222) slide respectively and run through sliding guide pipe (231) lateral wall setting, conveying link block (222) lower wall is put medicine board (232) upper wall with the shutoff respectively and is slided closely to paste.
5. A heated stirred reactor vessel for pharmacological agents according to claim 4, wherein: defeated medicine stockline (21) level sets up, defeated medicine stockline (21) upper wall middle part is run through fixedly and is equipped with and adds medicine box (211), it runs through reaction box (4) upper wall setting to add medicine box (211), defeated medicine stockline (21) lower wall array distributes and runs through fixedly and is equipped with puts medicine side pipe (212), put medicine side pipe (212) lateral wall down along with slide guide pipe (231) on along respectively fixed connection, conveying yoke block (222) upper wall respectively with put medicine side pipe (212) lower wall slip close subsides.
6. A heated stirred reactor vessel for pharmacological agents according to claim 5, wherein: indulge row differentiation heating mechanism (3) including heating controller (31) and hot plate (32), heating controller (31) runs through fixed locating reaction box (4) lateral wall respectively, hot plate (32) are fixed respectively and are located quadrature stirred tank (1) lower wall, one of them hot plate (32) upper wall and one of them are indulged and are listed as quadrature stirred tank (1) lower wall fixed connection, heating controller (31) lateral wall respectively with hot plate (32) tip lateral wall fixed connection, heating controller (31) lateral wall rotates and is equipped with temperature control button (311), hot plate (32) upper wall array distribution is fixed and is equipped with heating plate (321), heating plate (321) respectively with quadrature stirred tank (1) lower wall fixed connection, heating plate (321) respectively with heating controller (31) electric connection.
7. A heated stirred reactor vessel for pharmacological agents according to claim 6, wherein: fixed collection box (41) that is equipped with of reaction box (4) inside lower wall array distribution, single source lift stirring is located respectively from emission axle (111) below in collection box (41), single source lift stirring locates collection box (41) inner wall along sliding under emission axle (111) circumference lateral wall, reaction box (4) lower wall array distribution is fixed and is equipped with blowing tube head (42), blowing tube head (42) pass through the pipeline through connection one by one with collection box (41) lower wall.
CN202211125247.7A 2022-09-16 2022-09-16 A medicine heating stirring reactor for pharmacology Active CN115193325B (en)

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CN106488798A (en) * 2014-06-05 2017-03-08 艾卡工厂有限及两合公司 Agitating device and the laboratory equipment with this agitating device
CN209138634U (en) * 2018-11-20 2019-07-23 武汉欣朗科技有限公司 A kind of novel reaction kettle
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