CN115177570B - Composition with relieving and repairing effects and preparation method and application thereof - Google Patents
Composition with relieving and repairing effects and preparation method and application thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to a composition with a soothing and repairing effect, and a preparation method and application thereof. The composition with the relieving and repairing effects comprises the following preparation raw materials: radix Paeoniae extract, kava leaf/root/stem extract, radix Gentianae extract, moringa seed extract and butanediol. The composition prepared by the invention can realize remarkable effects of resisting allergy, relieving aging and repairing skin through interaction among the components, and meanwhile, the composition does not need to be added with a preservative, so that the irritation of the preservative to human skin can be effectively reduced, and the use safety of the composition is greatly improved.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition with a soothing and repairing effect, and a preparation method and application thereof.
Background
Healthy skin barriers help the skin to retain moisture and resist external irritation. However, people often contact with electronic products in life, so that people are often subjected to radiation of the electronic products, and are stimulated by air pollution, stay up and overtime, living pressure, anxiety, insufficient sun protection, excessive skin care and the like, and the skin of most people is not only lack of moisture, unbalanced oil and water of the skin, but also has the problems of anaphylactic redness, dry itching, stinging, red swelling and accelerated aging.
Most of the products currently on the market which are declared to have the efficacy of relieving and repairing are mainly used for blocking inflammation by adding various anti-allergic components, and the products can temporarily eliminate uncomfortable feelings such as itching and the like when being used, but only release of inflammatory factors is inhibited to relieve symptoms by a mechanism, and the acting path is single. In addition, the pharmacological treatment-based product has very weak repairing and nursing effects on skin, can only solve the appearance problems of the skin, and can not restore the healthy state of the skin by radically adjusting the barrier function and microecological balance. Therefore, there is a need to develop a composition having remarkable anti-allergy relieving, anti-aging and repairing effects and high safety.
Disclosure of Invention
The invention aims to provide a composition with a relieving and repairing effect, and a preparation method and application thereof. The composition has remarkable effects of resisting allergy, relieving aging and repairing skin, and meanwhile, the composition does not need to be added with preservative, so that the irritation of the preservative to human skin can be effectively reduced, and the use safety of the composition is greatly improved.
In order to achieve the above purpose, the present invention adopts the following technical scheme: a composition with the effect of relieving and repairing comprises the following preparation raw materials: radix Paeoniae extract, kava leaf/root/stem extract, radix Gentianae extract, moringa seed extract and butanediol.
Preferably, the composition with the soothing and repairing effects comprises the following components in parts by weight: 8-18 parts of paeonia lactiflora root extract, 1-8 parts of kava leaf/root/stem extract, 9-18 parts of gentian extract, 1-8 parts of moringa seed extract, 30-40 parts of butanediol and 5-55 parts of water.
Preferably, the composition with the soothing and repairing effects comprises the following components in parts by weight: 16 parts of paeonia lactiflora root extract, 6 parts of kava leaf/root/stem extract, 16 parts of gentian extract, 6 parts of moringa seed extract, 32 parts of butanediol and 24 parts of water.
A method for preparing the composition with the soothing and repairing effects, which comprises the following steps:
adding water with the formula amount into a stirring pot, heating, starting stirring, preserving heat, adding butanediol, stirring uniformly, sequentially adding radix paeoniae alba root extract, kava leaf/root/stem extract, radix gentianae extract and moringa seed extract, stirring uniformly, cooling, standing, and filtering to obtain the composition with the effects of relieving and repairing.
Preferably, the temperature is raised to 85-90 ℃.
Preferably, the time of heat preservation is 30-40 min.
Preferably, the temperature is reduced to 40 ℃; the standing time is 12-36 h.
Use of the composition with soothing and repairing effects in preparing cosmetics.
Preferably, the composition having a soothing and repairing effect is added to the cosmetic in an amount of 0.1 to 15.0% by mass of the total mass.
Preferably, the formulation of the cosmetic comprises: any one of water aqua, emulsion, cream, essence, facial mask and spray.
The paeonia lactiflora (PAEONIA ALBIFLORA) root extract has the effects of inhibiting elastase, eliminating free radicals, inhibiting nitrogen oxide generation, promoting cathepsin activity and the like, has the functions of activating skin and resisting aging, and has good moisturizing capability.
The kava (PIPER METHYSTICUM) leaf/root/stem extract is rich in kavalactones, mainly kavain-like active substances. Researches prove that the skin care product has good safety and can play the roles of immediately calming, resisting inflammation, removing acnes, relieving and helping sleep when being used for skin.
The GENTIANA SCABRA extract has good activation effect on luciferase, which shows that the GENTIANA SCABRA extract has remarkable inhibition effect on specific allergy (or itch) of skin and is used for relieving itching and red swelling caused by allergic sensitive muscles; in addition, the component has an effect of regulating the estrogen level of local skin, and shows a certain skin anti-aging effect; has effect in promoting secretion of epidermal cell cholesterol (skin softening component), and can also be used for effectively lubricating skin and improving skin elasticity.
Moringa OLEIFERA (Morina OLEIFERA) seed extract of the present invention: has excellent oxidation resistance, and can effectively maintain the water content of skin, purify the skin and resist environmental pollutants.
Compared with the prior art, the invention has the following beneficial effects:
the invention can effectively relieve allergic reactions such as skin redness and swelling, itching, inflammation and the like through interaction among the paeonia lactiflora root extract, kava leaf/root/stem extract, gentian extract and moringa seed extract, has higher free radical removal rate and can realize better anti-aging effect.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the examples and comparative examples, the experimental methods used were conventional methods, and the materials, reagents and the like used were commercially available, unless otherwise specified.
The preparation methods of the paeonia lactiflora (PAEONIA ALBIFLORA) root extract, kava (PIPER METHYSTICUM) leaf/root/stem extract, GENTIANA scanra (GENTIANA scanra) extract and MORINGA OLEIFERA (MORINGA OLEIFERA) seed extract selected in the embodiment of the invention are as follows:
root extract of paeonia lactiflora (PAEONIA ALBIFLORA): extracting radix Paeoniae powder with 10 times of purified water under reflux for 3 times (each for 1 hr), filtering, concentrating the extractive solution to obtain crude extract, adding 3 times of ethyl acetate, extracting for 2 times, evaporating the extractive solution, and vacuum drying to obtain radix Paeoniae extract.
Kava (PIPER METHYSTICUM) leaf/root/stem extract: pulverizing kava pepper raw material, treating at 115 deg.C under 0.20mpa, and drying to obtain kava pepper powder; extracting and decolorizing the obtained kava pepper powder with alcohol, and separating to obtain a solid; extracting the obtained solid with ethanol twice, filtering, and concentrating the liquid to obtain kava leaf/root/stem extract.
GENTIANA scanra (GENTIANA scanra) extract: reflux-extracting radix Gentianae powder with 10 times of purified water for 3 times (1 hr each time), filtering, and concentrating the extractive solution to obtain crude extract; adding 3 times of ethyl acetate into the crude extract, extracting for 2 times, evaporating the extract, and vacuum drying to obtain radix Gentianae extract.
Moringa OLEIFERA (MORINGA OLEIFERA) seed extract: the moringa seed bud leaf dry powder is added into a feed liquid with the ratio (weight: volume) of 1:60 Ethanol (40-80% by volume concentration) is vigorously shaken/stirred for 60s, ultrasonic waves are applied for 5min, standing is carried out for 5min, repeating is carried out for 3 times, then centrifugation is carried out at 4000rpm, supernatant fluid is concentrated by rotary evaporation, and freeze drying is carried out, thus obtaining the moringa seed extract.
Example 1 composition with soothing and repairing Effect of the present invention and method for preparing the same
The formula comprises the following components: 80g of paeonia lactiflora root extract, 10g of kava leaf/root/stem extract, 90g of gentian extract, 10g of moringa seed extract, 300g of butanediol and 510g of water.
The preparation method comprises the following steps: adding water in the formula amount into a stirring pot, heating to 85 ℃, starting stirring, preserving heat for 30min, adding butanediol, stirring uniformly, sequentially adding paeonia lactiflora root extract, kava leaf/root/stem extract, gentian extract and moringa seed extract, stirring uniformly, cooling to 40 ℃, standing for 12h, and filtering to obtain the composition with the effects of relieving and repairing.
Example 2 composition with soothing and repairing Effect of the present invention and method for preparing the same
The formula comprises the following components: 120g of paeonia lactiflora root extract, 30g of kava leaf/root/stem extract, 120g of gentian extract, 40g of moringa seed extract, 340g of butanediol and 350g of water.
The preparation method comprises the following steps: adding water in the formula amount into a stirring pot, heating to 85 ℃, starting stirring, preserving heat for 35min, adding butanediol, stirring uniformly, sequentially adding paeonia lactiflora root extract, kava leaf/root/stem extract, gentian extract and moringa seed extract, stirring uniformly, cooling to 40 ℃, standing for 24h, and filtering to obtain the composition with the effects of relieving and repairing.
Example 3 composition with soothing and repairing Effect of the present invention and method for preparing the same
The formula comprises the following components: 160g of paeonia lactiflora root extract, 60g of kava leaf/root/stem extract, 160g of gentian extract, 60g of moringa seed extract, 320g of butanediol and 240g of water.
The preparation method comprises the following steps: adding water in the formula amount into a stirring pot, heating to 85 ℃, starting stirring, preserving heat for 35min, adding butanediol, stirring uniformly, sequentially adding paeonia lactiflora root extract, kava leaf/root/stem extract, gentian extract and moringa seed extract, stirring uniformly, cooling to 40 ℃, standing for 24h, and filtering to obtain the composition with the effects of relieving and repairing.
Example 4 composition with soothing and repairing Effect of the present invention and method for preparing the same
The formula comprises the following components: 180g of paeonia lactiflora root extract, 80g of kava leaf/root/stem extract, 180g of gentian extract, 80g of moringa seed extract, 400g of butanediol and 60g of water.
The preparation method comprises the following steps: adding water in the formula amount into a stirring pot, heating to 90 ℃, starting stirring, preserving heat for 40min, adding butanediol, stirring uniformly, sequentially adding paeonia lactiflora root extract, kava leaf/root/stem extract, gentian extract and moringa seed extract, stirring uniformly, cooling to 40 ℃, standing for 36h, and filtering to obtain the composition with the effects of relieving and repairing.
Comparative example 1
Compared with example 3, this comparative example differs only in that: no paeonia lactiflora root extract is added.
The preparation method is described in example 3.
Comparative example 2
Compared with example 3, this comparative example differs only in that: the kava leaf/root/stem extract was not added.
The preparation method is described in example 3.
Comparative example 3
Compared with example 3, this comparative example differs only in that: no gentian extract was added.
The preparation method is described in example 3.
Comparative example 4
Compared with example 3, this comparative example differs only in that: no Moringa seed extract was added.
The preparation method is described in example 3.
Comparative example 5
Compared with example 3, this comparative example differs only in that: the paeonia lactiflora root extract is replaced by equivalent amount of C10-18 fatty acid triglyceride.
The preparation method is described in example 3.
Comparative example 6
Compared with example 3, this comparative example differs only in that: the kava leaf/root/stem extract was replaced with an equivalent amount of purslane extract.
The preparation method is described in example 3.
Comparative example 7
Compared with example 3, this comparative example differs only in that: the gentian extract was replaced with an equivalent amount of ceramide NP.
The preparation method is described in example 3.
Comparative example 8
Compared with example 3, this comparative example differs only in that: the moringa seed extract was replaced with an equivalent amount of acetyl hexapeptide-8.
The preparation method is described in example 3.
Test example one, product safety test
1. Experimental sample
The compositions with soothing and repairing effects prepared in examples 1 to 4 and comparative examples 1 to 8.
2. Experimental method
Verifying the safety of the sample through a human skin patch test; specifically, the subjects volunteer for selection, for a total of 195 females, age distribution 18-50 years, divided into 13 groups. The test components (compositions prepared in examples 1-4 and comparative examples 1-8) were removed after 2 hours in the closed patch test method, and skin reactions were observed in the patch tests for 0.5, 24 hours and 48 hours, respectively, according to the skin reaction classification standard (see Table 1) in "cosmetic safety evaluation procedure and method" GB 7919-87.
TABLE 1 skin response grading Standard for skin seal Patch test
3. Experimental results
The results of the number of skin reaction grades of each sample are shown in Table 2, and the data in Table 2 shows that the composition prepared in the examples of the present invention has no irritation to skin and high safety.
Table 2 skin reaction rating number of each sample
Test example two, water-moisturizing Effect test
1. Experimental sample
The compositions with soothing and repairing effects prepared in examples 1 to 4 and comparative examples 1 to 8.
2. Experimental method
130 volunteer subjects were selected, who were 18-50 years of age, all women, had no history of dermatological allergy, and were eligible for volunteer inclusion criteria.
Subjects were divided into 13 groups of 10 persons each, each group of subjects using the same composition sample. The subject draws a fixed area of 2 square centimeters on the inner side of the forearm of the hand in an indoor environment with the temperature of 20 ℃ and the relative humidity of 50%, uses the coated purified water as a blank group, and uses the composition in the fixed area, and uses a Corneometer CM285 skin moisture detector to measure the moisture content value of the skin at 0.1h, 0.5h, 1.5h, 2.5h, 4h and 6h after the coating is finished, and the moisture content improvement value is obtained by difference between the moisture content value and the blank value, wherein the larger the moisture preservation effect of the test sample is.
3. Experimental results
The experimental results are shown in table 3.
TABLE 3 improvement in moisture content of samples
| Group of | 0.1h | 0.5h | 1.5h | 2.5h | 4h |
| Blank group | 34.07 | 28.12 | 23.01 | 17.62 | 11.31 |
| Example 1 | 45.97 | 37.81 | 36.06 | 34.06 | 31.17 |
| Example 2 | 46.43 | 38.44 | 36.75 | 35.37 | 32.90 |
| Example 3 | 48.78 | 40.26 | 38.52 | 37.41 | 35.27 |
| Example 4 | 47.36 | 39.12 | 37.57 | 36.83 | 34.69 |
| Comparative example 1 | 36.77 | 31.35 | 25.32 | 21.81 | 17.55 |
| Comparative example 2 | 40.91 | 34.72 | 32.16 | 30.88 | 28.68 |
| Comparative example 3 | 41.13 | 35.65 | 33.75 | 31.21 | 29.35 |
| Comparative example 4 | 38.07 | 31.94 | 29.45 | 26.18 | 24.20 |
| Comparative example 5 | 39.02 | 33.91 | 31.18 | 28.81 | 27.39 |
| Comparative example 6 | 40.88 | 35.01 | 32.25 | 29.35 | 28.21 |
| Comparative example 7 | 40.07 | 34.61 | 32.21 | 30.66 | 28.46 |
| Comparative example 8 | 38.77 | 32.83 | 30.01 | 27.35 | 25.84 |
From the data in Table 3, it can be seen that the moisture content increase values of the compositions having a soothing and repairing effect of examples 1 to 4 of the present invention were significantly higher in the range of 0.1 to 4 hours than in the blank group, especially at the 4 th hour.
The absence of one of the four components of paeonia lactiflora root extract, kava leaf/root/stem extract, gentian extract, moringa seed extract in comparative examples 1 to 4 resulted in a significantly worse moisture content increase value within 0.1 to 4 hours for the prepared compositions than in examples; the comparative examples 5 to 8 all select one of the four components of paeonia root extract, kava leaf/root/stem extract, gentian extract and moringa seed extract to be replaced by one component with similar efficacy, but the moisturizing effect of the finally prepared composition is still worse than that of the embodiment, which shows that the synergistic effect among the four components of paeonia root extract, kava leaf/root/stem extract, gentian extract and moringa seed extract can effectively enhance the moisturizing effect of the prepared composition.
Test example three, test of relief repair effect
1. Experimental sample
The compositions with soothing and repairing effects prepared in examples 1 to 4 and comparative examples 1 to 8.
2. Experimental method
Group of subjects: 140 volunteers, each volunteer had different degrees of vaccinia inflammation on the face, and were randomly divided into 14 groups of 10 persons each, each group corresponding to the products of examples 1-3 and comparative examples 1-8, respectively, in units of groups, another group was a negative control (clear water), and another group was a positive control (commercial acne-removing ointment: vitamin A lactic acid ointment).
The testing method comprises the following steps: all volunteers apply the test samples to the whole face at an amount of 1+/-0.05 g/time according to the corresponding groups, and use the samples for 14 days each time in the morning and evening continuously without using other skin care products or products with similar efficacy; after the use, the curative effect of the product is evaluated by adopting a scoring system, the improvement condition of various symptoms (including 5 symptoms of thorny pain, burning sensation, itching, swelling and inflammation fading, and no score is generated if the symptoms are absent) is adopted, the score is 5 minutes full, the score is higher, the effect of relieving and repairing the symptoms is better, the average score is calculated after the highest score and the lowest score are removed from each group, and the comprehensive effect of the statistical test sample is calculated by the average score of each symptom.
3. Experimental results
The experimental results are shown in table 4.
TABLE 4 results of sample relief repair
As can be seen from the data in table 4, the compositions having soothing and repairing effects of examples 1 to 4 of the present invention have remarkable soothing effects on skin tingling, burning sensation, itching, swelling, inflammation and the like, compared to the negative control group, and the effect thereof is close to that of the tretinoin lactic acid paste in the positive control group.
The absence of kava leaf/root/stem extract, gentian extract with sedative and soothing effects in comparative examples 2 to 3 resulted in the resulting composition being significantly inferior to the examples in soothing and repairing skin; the absence of paeonia root extract in comparative example 1 and moringa seed extract in comparative example 4, lack of interaction between the four components, resulted in the resulting composition having a less soothing and repairing effect than the examples.
Comparative examples 6 to 7, in which the kava leaf/root/stem extract and gentian extract were replaced with components having similar effects, the prepared composition had a soothing and repairing effect which was inferior to that of the negative control group, though it was better.
Test example four, anti-aging efficacy test
1. Experimental sample
The compositions with soothing and repairing effects prepared in examples 1 to 4 and comparative examples 1 to 8.
2. Experimental method
1-diphenyl-2-trinitrophenylhydrazine (DPPH) is taken as a stable free radical and can be removed by other antioxidant active substances, so that the antioxidant capacity can be quantitatively measured, and the method is widely used for quantitatively measuring the antioxidant capacity of biological samples at present. The method is based on the fact that DPPH free radical has single electron, has strong absorption at 517nm, and the alcohol solution is purple. When a radical scavenger exists, the free radical scavenger is paired with a single electron to gradually disappear, and the fading degree is quantitatively related to the number of the accepted electrons, so that the free radical scavenger can be performed by a spectrophotometer. In this experiment, BHT (2, 6-di-t-butyl-p-cresol) was used as a control, and was applied as shown in Table 5 below. DPPH clearance x= [1- (A1-A2)/A0 ]. Times.100%, the bigger clearance indicates that the antioxidation capability is stronger, the removal rate of 0.5% BHT to DPPH free radical is 70.01% by taking BHT as a control, and the mass percentage of the test sample is also 0.5%.
Table 5 ratios of test samples
3. Experimental results
The anti-aging effect of each sample is shown in table 6.
TABLE 6 anti-aging effect results for each sample
| Sample of | DPPH clearance (%) |
| 0.5％BHT | 70.01 |
| Example 1 | 72.38 |
| Example 2 | 73.24 |
| Example 3 | 75.25 |
| Example 4 | 74.86 |
| Comparative example 1 | 65.34 |
| Comparative example 2 | 68.61 |
| Comparative example 3 | 64.42 |
| Comparative example 4 | 60.37 |
| Comparative example 5 | 65.63 |
| Comparative example 6 | 69.96 |
| Comparative example 7 | 67.42 |
| Comparative example 8 | 64.51 |
From the data in Table 6, it can be seen that the compositions with soothing and repairing effects prepared in examples 1 to 4 of the present invention have a better DPPH free radical removing ability.
The compositions of comparative examples 1 to 4, which lack one of the four components of paeonia lactiflora root extract, kava leaf/root/stem extract, gentian extract, moringa seed extract, had a less DPPH radical removal ability than the examples;
comparative examples 5 to 8, in which one of the four components of paeonia root extract, kava leaf/root/stem extract, gentian extract, moringa seed extract was replaced with components having similar effects, the compositions had slightly better DPPH radical scavenging ability than comparative examples 1 to 4, but the final compositions still had significantly worse DPPH radical scavenging ability than examples due to the absence of interactions between the paeonia root extract, kava leaf/root/stem extract, gentian extract, moringa seed extract components.
The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.
Claims (9)
1. The composition with the soothing and repairing effects is characterized by comprising the following components in parts by weight: 8-18 parts of paeonia lactiflora root extract, 1-8 parts of kava leaf/root/stem extract, 9-18 parts of gentian extract, 1-8 parts of moringa seed extract, 30-40 parts of butanediol and 5-55 parts of water;
the preparation method of the paeonia lactiflora root extract comprises the following steps: extracting radix Paeoniae powder with 10 times of purified water under reflux for 3 times (each for 1 hr), filtering, concentrating the extractive solution to obtain crude extract, adding 3 times of ethyl acetate into the crude extract, extracting for 2 times, evaporating the extractive solution, and vacuum drying to obtain radix Paeoniae extract;
the preparation method of the kava leaf/root/stem extract comprises the following steps: pulverizing kava pepper raw material, treating at 115 deg.C under 0.20mpa, and drying to obtain kava pepper powder; extracting and decolorizing the obtained kava pepper powder with alcohol, and separating to obtain a solid; extracting the obtained solid with ethanol twice, filtering, and concentrating the liquid to obtain kava leaf/root/stem extract;
the preparation method of the gentian extract comprises the following steps: reflux-extracting radix Gentianae powder with 10 times of purified water for 3 times (1 hr each time), filtering, and concentrating the extractive solution to obtain crude extract; adding 3 times of ethyl acetate into the crude extract, extracting for 2 times, evaporating the extract to dryness, and vacuum drying to obtain radix Gentianae extract;
the preparation method of the moringa seed extract comprises the following steps: the ratio of the added moringa seed bud leaf dry powder to the feed liquid is 1:60 is ethanol with volume concentration of 40-80%, shaking/stirring for 60s, ultrasonic treating for 5min, standing for 5min, repeating for 3 times, centrifuging at 4000rpm, concentrating supernatant by rotary evaporation, and lyophilizing to obtain Moringa seed extract.
2. The composition with soothing and repairing effect according to claim 1, which comprises the following components in parts by weight: 16 parts of paeonia lactiflora root extract, 6 parts of kava leaf/root/stem extract, 16 parts of gentian extract, 6 parts of moringa seed extract, 32 parts of butanediol and 24 parts of water.
3. A method for preparing the composition with soothing and repairing effects according to any one of claims 1 to 2, comprising the following steps:
adding water with the formula amount into a stirring pot, heating, starting stirring, preserving heat, adding butanediol, stirring uniformly, sequentially adding radix paeoniae alba root extract, kava leaf/root/stem extract, radix gentianae extract and moringa seed extract, stirring uniformly, cooling, standing, and filtering to obtain the composition with the effects of relieving and repairing.
4. A method of preparation according to claim 3 wherein the temperature is raised to 85-90 ℃.
5. The preparation method of claim 3, wherein the heat preservation time is 30-40 min.
6. The method of claim 3, wherein the temperature is reduced to 40 ℃; and standing for 12-36 hours.
7. Use of the composition with soothing and repairing effects according to any one of claims 1 to 2 in the preparation of cosmetics.
8. The use according to claim 7, wherein the composition having a soothing and repairing effect is added to the cosmetic in an amount of 0.1 to 15.0% by mass of the total mass.
9. The use according to claim 7, wherein the formulation of the cosmetic comprises: any one of water aqua, emulsion, cream, essence, facial mask and spray.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000319120A (en) * | 1999-05-10 | 2000-11-21 | Ichimaru Pharcos Co Ltd | Cosmetic composition including vegetable extract having moisture retaining property |
| JP2001122730A (en) * | 1999-10-26 | 2001-05-08 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing moisturizing plant extract |
| WO2006053415A1 (en) * | 2004-11-18 | 2006-05-26 | Biopharmacopae Design International Inc. | Plant extract having matrix metalloprotease inhibiting activity and dermatological uses thereof |
| CN111728907A (en) * | 2020-06-30 | 2020-10-02 | 广州市科能化妆品科研有限公司 | Soothing and anti-allergy composition, preparation method thereof and application thereof in cosmetics |
| CN111920724A (en) * | 2020-09-16 | 2020-11-13 | 广州和佳润颜医药有限公司 | Skin care composition for repairing sensitive muscle |
| CN114224818A (en) * | 2021-12-15 | 2022-03-25 | 仙婷(广州)科技研发有限公司 | Anti-allergy composition and preparation method and application thereof |
| CN114557930A (en) * | 2022-03-01 | 2022-05-31 | 国妆(广州)科技有限公司 | Essence with effects of relieving skin inflammation and repairing skin |
-
2022
- 2022-08-17 CN CN202210988067.5A patent/CN115177570B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000319120A (en) * | 1999-05-10 | 2000-11-21 | Ichimaru Pharcos Co Ltd | Cosmetic composition including vegetable extract having moisture retaining property |
| JP2001122730A (en) * | 1999-10-26 | 2001-05-08 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing moisturizing plant extract |
| WO2006053415A1 (en) * | 2004-11-18 | 2006-05-26 | Biopharmacopae Design International Inc. | Plant extract having matrix metalloprotease inhibiting activity and dermatological uses thereof |
| CN111728907A (en) * | 2020-06-30 | 2020-10-02 | 广州市科能化妆品科研有限公司 | Soothing and anti-allergy composition, preparation method thereof and application thereof in cosmetics |
| CN111920724A (en) * | 2020-09-16 | 2020-11-13 | 广州和佳润颜医药有限公司 | Skin care composition for repairing sensitive muscle |
| CN114224818A (en) * | 2021-12-15 | 2022-03-25 | 仙婷(广州)科技研发有限公司 | Anti-allergy composition and preparation method and application thereof |
| CN114557930A (en) * | 2022-03-01 | 2022-05-31 | 国妆(广州)科技有限公司 | Essence with effects of relieving skin inflammation and repairing skin |
Non-Patent Citations (1)
| Title |
|---|
| 王建新.《化妆品植物原料大全》.中国纺织出版社,2012,第227-228、332-333页. * |
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