CN115151630A - 核酸提取微流控芯片、核酸提取装置及提取方法 - Google Patents

核酸提取微流控芯片、核酸提取装置及提取方法 Download PDF

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CN115151630A
CN115151630A CN202080002055.XA CN202080002055A CN115151630A CN 115151630 A CN115151630 A CN 115151630A CN 202080002055 A CN202080002055 A CN 202080002055A CN 115151630 A CN115151630 A CN 115151630A
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nucleic acid
groove
liquid
channel
extraction
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王嘉鹏
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BOE Technology Group Co Ltd
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Abstract

一种核酸提取微流控芯片、核酸提取装置及提取方法。核酸提取微流控芯片，沟道板(1)包括：混合裂解区(100)，位于混合裂解区(100)一侧的提取区(200)，与外界连通的气压驱动口(13)，连通混合裂解区(100)与提取区(200)的第一类通道(14)，以及连通提取区(200)与气压驱动口(13)的第二类通道(15)；盖板(2)，与沟道板(1)相对设置，盖板(2)在与混合裂解区(100)对应的位置具有进样口(160)和进液类通孔(22)；溶液容置腔(3)，位于盖板(2)的背离沟道板(1)的一侧，溶液容置腔(3)通过进液类通孔(22)与沟道板(1)的混合裂解区(100)连通。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN202080002055.XA 2020-09-22 2020-09-22 核酸提取微流控芯片、核酸提取装置及提取方法 Pending CN115151630A (zh)

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116103139B (zh) * 2023-04-14 2023-07-25 杭州霆科生物科技有限公司 一种全封闭式全集成核酸检测微流控芯片

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080227185A1 (en) * 2004-01-28 2008-09-18 Norchip As Diagnostic System for Carrying Out a Nucleic Acid Sequence Amplification and Detection Process
US20090035847A1 (en) * 2007-07-31 2009-02-05 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid detection and microfluidic system including the same
US20120138833A1 (en) * 2010-12-02 2012-06-07 Joseph Matteo Multi-Function Eccentrically Actuated Microvalves and Micropumps
CN102679039A (zh) * 2012-05-07 2012-09-19 博奥生物有限公司 一种集成于微流控芯片内的气动微阀
CN103335154A (zh) * 2013-07-15 2013-10-02 大连海事大学 一种集成于微流控芯片上的电磁微阀
CN203925955U (zh) * 2014-07-10 2014-11-05 大连海事大学 一种基于微流控芯片的电磁微泵
CN105536898A (zh) * 2015-12-14 2016-05-04 清华大学 微流控芯片、血细胞分离方法与***及该***的制作方法
CN205687904U (zh) * 2016-06-17 2016-11-16 博奥生物集团有限公司 一种用于核酸提取的微流控装置及控制***
CN106660058A (zh) * 2014-05-16 2017-05-10 克维拉公司 用于执行自动化离心分离的设备、***和方法
CN206637105U (zh) * 2017-04-06 2017-11-14 青岛意诚融智生物仪器有限公司 一种用于微流控芯片的电磁微阀
CN107615068A (zh) * 2015-05-28 2018-01-19 彼克斯赛尔医疗科技有限公司 流体样品分析***
CN109536366A (zh) * 2018-11-29 2019-03-29 合肥中科易康达生物医学有限公司 一种基于改性毛细管的核酸检测微流控芯片及核酸检测***
CN110343611A (zh) * 2019-08-14 2019-10-18 无锡研奥电子科技有限公司 一种微流控芯片
CN110656108A (zh) * 2019-10-31 2020-01-07 东莞市东阳光诊断产品有限公司 芯片、核酸提取纯化装置以及核酸提取纯化方法
CN111057638A (zh) * 2018-10-17 2020-04-24 北京致雨生物科技有限公司 样本处理装置及方法，以及包括该处理装置的数字pcr***
CN210656872U (zh) * 2019-05-06 2020-06-02 融智生物科技（青岛）有限公司 一种核酸提取微流控芯片
CN115400806A (zh) * 2022-09-23 2022-11-29 广东和信健康科技有限公司 一体化核酸提取微流控芯片盒和核酸提取及检测方法
CN115703993A (zh) * 2021-08-17 2023-02-17 北京京东方技术开发有限公司 微流控芯片、其核酸提取方法及核酸提取装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8435465B2 (en) * 2008-11-03 2013-05-07 Cfd Research Corporation Microfluidic biological extraction chip
CN108841818B (zh) * 2018-03-13 2022-09-06 融智生物科技（青岛）有限公司 一种核酸提取方法及装置
CN110257245A (zh) * 2019-07-16 2019-09-20 东莞博识生物科技有限公司 核酸检测试剂卡
CN111592971B (zh) * 2020-07-07 2024-03-15 江苏汇先医药技术有限公司 一种用于核酸检测的微流控芯片及方法

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080227185A1 (en) * 2004-01-28 2008-09-18 Norchip As Diagnostic System for Carrying Out a Nucleic Acid Sequence Amplification and Detection Process
US20090035847A1 (en) * 2007-07-31 2009-02-05 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid detection and microfluidic system including the same
US20120138833A1 (en) * 2010-12-02 2012-06-07 Joseph Matteo Multi-Function Eccentrically Actuated Microvalves and Micropumps
CN102679039A (zh) * 2012-05-07 2012-09-19 博奥生物有限公司 一种集成于微流控芯片内的气动微阀
CN103335154A (zh) * 2013-07-15 2013-10-02 大连海事大学 一种集成于微流控芯片上的电磁微阀
CN106660058A (zh) * 2014-05-16 2017-05-10 克维拉公司 用于执行自动化离心分离的设备、***和方法
CN203925955U (zh) * 2014-07-10 2014-11-05 大连海事大学 一种基于微流控芯片的电磁微泵
CN107615068A (zh) * 2015-05-28 2018-01-19 彼克斯赛尔医疗科技有限公司 流体样品分析***
CN105536898A (zh) * 2015-12-14 2016-05-04 清华大学 微流控芯片、血细胞分离方法与***及该***的制作方法
CN205687904U (zh) * 2016-06-17 2016-11-16 博奥生物集团有限公司 一种用于核酸提取的微流控装置及控制***
CN206637105U (zh) * 2017-04-06 2017-11-14 青岛意诚融智生物仪器有限公司 一种用于微流控芯片的电磁微阀
CN111057638A (zh) * 2018-10-17 2020-04-24 北京致雨生物科技有限公司 样本处理装置及方法，以及包括该处理装置的数字pcr***
CN109536366A (zh) * 2018-11-29 2019-03-29 合肥中科易康达生物医学有限公司 一种基于改性毛细管的核酸检测微流控芯片及核酸检测***
CN210656872U (zh) * 2019-05-06 2020-06-02 融智生物科技（青岛）有限公司 一种核酸提取微流控芯片
CN110343611A (zh) * 2019-08-14 2019-10-18 无锡研奥电子科技有限公司 一种微流控芯片
CN110656108A (zh) * 2019-10-31 2020-01-07 东莞市东阳光诊断产品有限公司 芯片、核酸提取纯化装置以及核酸提取纯化方法
CN115703993A (zh) * 2021-08-17 2023-02-17 北京京东方技术开发有限公司 微流控芯片、其核酸提取方法及核酸提取装置
WO2023020220A1 (zh) * 2021-08-17 2023-02-23 京东方科技集团股份有限公司 微流控芯片、其核酸提取方法及核酸提取装置
CN115400806A (zh) * 2022-09-23 2022-11-29 广东和信健康科技有限公司 一体化核酸提取微流控芯片盒和核酸提取及检测方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. F. HESS等: ""Review on pneumatic operations in centrifugal microfluidics"", LAB ON A CHIP, vol. 19, no. 22, 27 September 2019 (2019-09-27), pages 2745 - 3770 *
沈玉勤等: ""磁场控制技术在微流控芯片中的应用"", 化学进展, vol. 22, no. 1, 31 January 2010 (2010-01-31), pages 133 - 138 *

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