CN115025663A

CN115025663A - Preparation equipment and process of levocarnitine injection

Info

Publication number: CN115025663A
Application number: CN202210810219.2A
Authority: CN
Inventors: ***; 刘雅辉; 李述智; 张柳香
Original assignee: Hainan Zhuoke Pharmaceutical Co ltd
Current assignee: Hainan Zhuoke Pharmaceutical Co ltd
Priority date: 2022-07-11
Filing date: 2022-07-11
Publication date: 2022-09-09
Anticipated expiration: 2042-07-11
Also published as: CN115025663B

Abstract

The application discloses levocarnitine injection preparation equipment, which relates to the technical field of dispensing equipment and comprises a medicine mixing bin and a stirring and mixing component, wherein the stirring and mixing component comprises a central rotating rod and a stirring rod; the central rotating rod is rotatably connected to the upper cover and communicated with the conveying assembly, and comprises a hollow rod body and a rod body rotation driving assembly; the hollow rod body is tubular; the stirring rods are in a sleeve structure and are positioned on the central rotating rod, and each stirring rod comprises an outer layer pipe and an inner layer pipe; the end part of the outer layer pipe, which is far away from the central rotating rod, is closed and fixed on the inner layer pipe, and a hollow cylindrical space is formed between the outer layer pipe and the inner layer pipe; water permeable holes are densely distributed on the outer layer pipe; the inner layer pipe is tubular, and the space in the inner layer pipe and the hollow cylindrical space are communicated with the inner space of the central rotating rod; the technical effects that the blending efficiency of the levocarnitine injection preparation equipment is high, and the levocarnitine injection preparation equipment can efficiently mix liquid medicine right below the center of the stirring assembly are achieved.

Description

Preparation equipment and process of levocarnitine injection

Technical Field

The invention relates to the technical field of dispensing equipment, in particular to equipment and a process for preparing levocarnitine injection.

Background

Levocarnitine is an amino acid-like substance which promotes fat to be converted into energy, has no toxic or side effect on human bodies, is necessary for fat metabolism, can be used for treating chronic renal failure, cardiomyopathy, coronary heart disease, organic acidemia and the like, and can also be used as an auxiliary treatment medicine for chronic liver diseases.

Common dosage forms of the L-carnitine comprise L-carnitine tablets, L-carnitine oral solution, L-carnitine for injection and L-carnitine injection; in the preparation process of the levocarnitine injection, levocarnitine is added into injection water and then stirred until the mixture is uniformly mixed, and a pH value regulator is added and then the mixture is stirred and uniformly mixed; in order to achieve the purpose of uniform mixing, generally, a longer stirring time is needed (multiple times of stirring generally needs more than 20 minutes to mix uniformly), which is an important factor influencing the preparation efficiency of the levocarnitine injection; and the stirring subassembly among the configuration equipment among the prior art generally only rotates the purpose that realizes the mixing around the axis of the back shaft (the axis of rotation) of puddler through the control puddler, because of being subject to the influence of the pivoted linear velocity of the puddler portion that is close to the axis of rotation, is relatively poor to the mixed effect to the liquid medicine that is located the region (the position that is close to medicine mixing bin bottom) directly below the stirring subassembly central point and puts, and then influences whole mixed effect.

Therefore, a levocarnitine injection preparation apparatus which has high mixing efficiency and can efficiently mix a liquid medicine right under the center position of the stirring assembly is required.

Disclosure of Invention

The embodiment of the application provides a levocarnitine injection configuration equipment, the problem of configuration equipment among the prior art because of being limited by the influence of the pivoted linear velocity of the stirring rod part near the axis of rotation is solved, the mixing effect to the regional liquid medicine that is located under the central point of stirring subassembly is relatively poor and the configuration equipment is to the lower technical problem of the mixing efficiency of liquid medicine, the technical effect that levocarnitine injection configuration equipment mixing efficiency is high and can carry out high-efficient mixing to the liquid medicine under the central point of stirring subassembly has been realized.

The embodiment of the application provides levocarnitine injection preparation equipment which comprises a medicine mixing bin and a stirring and mixing assembly, wherein the medicine mixing bin comprises an outer shell, an upper cover, a conveying assembly, a medicine adding assembly and a pumping assembly; the stirring and mixing assembly comprises a central rotating rod and a stirring rod;

the central rotating rod is rotatably connected to the upper cover, is communicated with the conveying assembly and comprises a hollow rod body and a rod body rotation driving assembly;

the hollow rod body is tubular; the stirring rods are in a sleeve structure and are positioned on the central rotating rod, and an included angle between the axis and the axis of the central rotating rod is 30-90 degrees and comprises an outer layer pipe and an inner layer pipe;

the end part of the outer layer pipe, which is far away from the central rotating rod, is closed and fixed on the inner layer pipe, and a hollow cylindrical space is formed between the outer layer pipe and the inner layer pipe;

the outer layer pipe is densely provided with water permeable holes;

the inner-layer pipe is tubular, and the space in the inner-layer pipe and the hollow cylindrical space are communicated with the inner space of the central rotating rod;

during the stirring, the pumping module cooperation conveying assembly pumps the liquid in the medicine mixing bin to central dwang inner space, exports from the bottom of the hollow body of rod, the tip of inlayer pipe and the hole of permeating water respectively.

Preferably, the stirring rod rotating assembly is further included;

the stirring rod rotating assembly comprises a bearing block, a rotating block and a driving system;

the bearing blocks are fixed on the outer wall of the central rotating rod, correspond to the stirring rods one by one and are used for bearing the rotating blocks;

the rotating block is rotatably connected to the bearing block, and the axial direction of the rotating shaft is perpendicular to the axial direction of the central rotating rod;

the end part of the stirring rod close to the central rotating rod is fixed on the central rotating rod, and the angle between the stirring rod and the central rotating rod is 30-60 degrees;

the inner space of the stirring rod is communicated with the inner space of the central rotating rod through the bearing block and the rotating block;

the driving system is used for driving the rotating block to rotate around the axis of the rotating block.

Preferably, the device further comprises a closing plate assembly;

the main body of the sealing plate component is a plate and is used for controlling the water yield of the stirring rod in a mode of shielding the water inlet under the control of the control unit so as to control the water yield of the bottom of the central rotating rod;

the sealing plate assembly comprises a sealing plate, a positioning frame and a plate body lifting assembly;

the sealing plates correspond to the water inlets of the rotating blocks one by one and are fixed on the positioning frame, and the positioning frame is of a frame structure and is positioned in the central rotating rod and positioned on the upper cover;

the plate body lifting assembly is of a telescopic rod structure and is controlled by the control unit, and the plate body lifting assembly is used for driving the positioning frame to move up and down so as to control the water yield of the stirring rod.

Preferably, the device also comprises a warehouse cleaning component;

the bin cleaning assembly comprises an extruded water plate assembly and a water curtain generating assembly; the position of the hollow rod body close to the bottom is a special-shaped pipe part, and the inner diameter of the special-shaped pipe part is larger than that of other positions of the hollow rod body;

the extruded water plate assembly is used for controlling water outlet at the bottom of the central rotating rod and comprises a positioning frame, a plugging plate, a force application pressure spring, a limiting ring, a lifting extrusion rod and a supporting body; the positioning frame is of a frame structure, is fixed on the inner wall of the hollow rod body, is positioned above the special-shaped pipe part and is used for positioning the force application pressure spring;

the limiting ring is annular, is fixed on the inner wall of the hollow rod body, is arranged close to the end part of the central rotating rod, is positioned below the special-shaped pipe part and is used for bearing the plugging plate;

the plugging plate is abutted against the limiting ring and used for plugging water flow;

the force application pressure spring is positioned between the positioning frame and the plugging plate and is used for extruding the plugging plate;

the lifting extrusion rod is fixed on the inner wall of the medicine mixing bin through a support body, is a telescopic rod, is controlled by the control unit, and the top of the lifting extrusion rod is abutted against the bottom of the plugging plate;

after the lifting extrusion rod pushes the plugging plate to move upwards, the plugging plate enters the special-shaped pipe part, and liquid in the central rotating rod flows out from the bottom;

the water curtain generating assembly is positioned right below the central rotating rod and is used for forming the inner wall of the annular water curtain cleaning medicine mixing bin and the stirring and mixing assembly, and the water curtain generating assembly comprises a water guide disc, a water guide blade and a blade rotating assembly;

the water guide disc is fixed on the medicine mixing bin, is positioned right below the central rotating rod and is in a disc shape, a water through hole is positioned in the center of the water guide disc and is used for allowing the lifting extrusion rod and part of liquid medicine output from the bottom of the central rotating rod to pass through, and the diameter of the water through hole is 2-5 cm larger than that of the lifting extrusion rod;

the water guide blades are arc-shaped sheet bodies, the number of the water guide blades is 8 or more, the water guide blades are rotatably connected to the water guide disc and are uniformly distributed on the periphery of the water guide disc, and the plurality of water guide discs and the water guide blades are combined to form a bowl shape;

the blade rotating assembly is used for controlling all the water guide blades to rotate so as to change the size of a bowl opening of a combination of the bowl-shaped water guide disc and the water guide blades and further change the direction of the water curtain.

Further, the blade rotating assembly comprises a force application ring and a force application ring lifting assembly;

the force application ring is sleeved on a ring formed by the water guide blades, and the force application ring lifting assembly is used for controlling the lifting of the force application ring so as to control the rotation of the water guide blades.

Preferably, a hole plugging block is further fixed on the lifting extrusion rod and used for plugging the water passing hole after the lifting extrusion rod rises to a certain degree;

clear storehouse subassembly still includes second water curtain and generates the subassembly, and the structure that second water curtain generated the subassembly is the same with the structure that water curtain generated the subassembly, fixes on the upper cover, second water curtain generated the subassembly and water curtain generated the subassembly symmetry and sets up, all is controlled by the control unit.

Furthermore, the conveying assembly is positioned on the upper cover, is a combination of a pump and a pipeline, is communicated with the raw material bin for injection water and the pumping assembly, and plays a role in conveying liquid, gas and energy to the stirring and mixing assembly;

the medicine adding assembly is positioned on the upper cover, is communicated with the solid raw material bin, comprises a quantitative discharging assembly and is used for timely throwing quantitative solid medicines into the medicine mixing bin through an input port on the upper cover;

the pumping assembly is a combination of a pump body, a valve body and a pipeline, is positioned at the bottom of the outer shell and plays a role in pumping out liquid in the medicine mixing bin and conveying the liquid to the filtering bin or the conveying assembly.

Preferably, a flow limiting plate is fixed on the inner wall of the hollow rod body at a position close to the bottom, and the flow limiting plate is an annular plate and is used for reducing the amount of liquid output from the bottom of the hollow rod body in unit time.

Further, the drive system is positioned inside the central swivelling lever, comprising a central drive rod, a first gear ring and a second gear ring;

the central driving rod is a combination of a motor and a rod body, is positioned on the upper cover and rotates around the axis of the central driving rod under the control of the control unit;

the number of the first gear rings and the number of the second gear rings are the same as that of the stirring rods;

the first gear ring is fixed on the central driving rod, and the axial direction of the first gear ring is the same as the axial direction of the central driving rod;

the second gear ring is fixed on the rotating block, and the axis of the second gear ring is overlapped with the axis of the rotating block and meshed with the first gear ring.

One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:

through improving the stirring assembly of the configuration equipment in the prior art, the supporting shaft of the stirring assembly is optimized into a tubular structure, the stirring rod is arranged into a sleeve structure, the inner layer pipe body of the stirring rod is used for forming and outputting a water column with the axis coinciding with the axis of the stirring rod for stirring, through holes for water permeation are densely distributed on the outer layer pipe body, one end of the outer layer pipe body, which is far away from the supporting shaft, is fixed on the inner layer pipe body, a hollow cylindrical space is formed between the outer layer pipe body and the inner layer pipe body, and the space in the inner layer pipe body and the hollow cylindrical space are communicated with the inner space of the supporting shaft; during stirring, the pumping assembly pumps the liquid in the medicine mixing bin to the inner space of the support shaft, and the liquid is respectively output from the bottom of the support shaft, the end part of the inner-layer pipe body and the through holes on the outer-layer pipe body to perform accelerated stirring and mixing on the liquid medicine; the technical problems that the mixing effect of the liquid medicine in the area under the central position of the stirring assembly is poor and the mixing efficiency of the configuration equipment to the liquid medicine is low due to the fact that the configuration equipment in the prior art is limited by the rotating linear speed of the stirring rod part close to the rotating shaft are solved, and the technical effects that the mixing efficiency of the configuration equipment for the levocarnitine injection is high and the liquid medicine under the central position of the stirring assembly can be efficiently mixed are achieved.

Drawings

FIG. 1 is a schematic structural view of a stirring and mixing assembly of the levocarnitine injection preparation apparatus according to the present invention;

FIG. 2 is a schematic view of the external structure of the levocarnitine injection preparation device of the present invention;

FIG. 3 is a schematic structural diagram of a stirring rod of the levocarnitine injection preparation device of the present invention;

FIG. 4 is a schematic diagram showing the positional relationship between the stirring rod and the stirring rod rotating assembly of the levocarnitine injection solution preparing apparatus according to the present invention;

FIG. 5 is a schematic diagram showing the positional relationship between the hollow rod body and the restrictor plate of the levocarnitine injection preparation apparatus according to the present invention;

FIG. 6 is a schematic view of the structure of the central rotating rod and the rotation driving assembly of the levocarnitine injection solution configuration device according to the present invention;

FIG. 7 is a schematic structural view of a stirring rod and a stirring rod rotating assembly of the levocarnitine injection preparation apparatus of the present invention;

FIG. 8 is a cross-sectional view of a stirring rod and a stirring rod rotating assembly of the levocarnitine injection solution preparation device according to the present invention;

FIG. 9 is a schematic view of a partial structure of a stirring rod of the levocarnitine injection preparation device according to the present invention;

FIG. 10 is a schematic structural diagram of a driving system and a sealing plate assembly of the levocarnitine injection solution preparation device according to the present invention;

FIG. 11 is a schematic view of the exterior structure of the bin cleaning assembly of the levocarnitine injection preparation device according to the present invention;

FIG. 12 is a schematic view of the internal structure of the extruded water plate assembly of the levocarnitine injection dispensing apparatus of the present invention;

FIG. 13 is a cross-sectional view of an extruded water plate assembly of the levocarnitine injection dispensing apparatus of the present invention;

fig. 14 is a schematic structural diagram of a water curtain generating assembly of the levocarnitine injection solution configuration device according to the present invention;

fig. 15 is a schematic diagram of the position relationship between the water curtain generating assembly and the second water curtain generating assembly of the levocarnitine injection solution configuration device of the present invention.

In the figure:

the drug mixing bin 100, the outer shell 110, the upper cover 120, the input port 121, the support frame 130, the delivery assembly 140, the drug adding assembly 150, and the pumping assembly 160;

the stirring and mixing assembly 200, a central rotating rod 210, a hollow rod body 211, a flow limiting plate 212, a rod body rotating driving assembly 213, a stirring rod 220, an outer layer pipe 221, an inner layer pipe 222, a water permeable hole 224, a stirring rod rotating assembly 230, a bearing block 231, a rotating block 232, a driving system 233, a central driving rod 234, a first gear ring 235, a second gear ring 236, a sealing plate assembly 240, a sealing plate 241, a positioning frame 242, a plate body lifting assembly 243 and a special-shaped pipe part 250;

the device comprises a bin cleaning assembly 300, an extruded water plate assembly 310, a positioning frame 311, a blocking plate 312, a force application pressure spring 313, a limiting ring 314, a lifting extrusion rod 315, a hole blocking block 316, a support body 317, a water curtain generating assembly 320, a water guide disc 321, a water passing hole 322, a water guide blade 323, a blade rotating assembly 324, a force application ring 325, a force application ring lifting assembly 326 and a second water curtain generating assembly 330.

Detailed Description

In order to facilitate an understanding of the present invention, the present application will now be described more fully with reference to the accompanying drawings; the preferred embodiments of the present invention are illustrated in the accompanying drawings, but the invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete.

It is noted that the terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs; the terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention; as used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

Fig. 1 is a schematic structural diagram of a stirring and mixing assembly of the levocarnitine injection preparation device according to the present invention; the levocarnitine injection preparation equipment is characterized in that a stirring assembly of the preparation equipment in the prior art is improved, a supporting shaft of the stirring assembly is optimized into a tubular structure, a stirring rod is arranged into a sleeve structure, an inner layer pipe 222 of the stirring rod is used for forming and outputting a water column with an axis coinciding with that of the stirring rod for stirring, through holes for water permeation are densely distributed in an outer layer pipe 221, one end, away from the supporting shaft, of the outer layer pipe 221 is fixed on the inner layer pipe 222, a hollow cylindrical space is formed between the outer layer pipe 221 and the inner layer pipe 222, and the space and the hollow cylindrical space in the inner layer pipe 222 are communicated with the inner space of the supporting shaft; during stirring, the pumping assembly pumps the liquid in the medicine mixing bin 100 to the inner space of the support shaft, and the liquid is respectively output from the bottom of the support shaft, the end part of the inner layer pipe 222 and the through hole on the outer layer pipe 221 to perform accelerated stirring and mixing on the liquid medicine; the technical effects that the blending efficiency of the levocarnitine injection preparation equipment is high, and the levocarnitine injection preparation equipment can efficiently mix liquid medicine right below the center of the stirring assembly are achieved.

Example one

As shown in fig. 1, the levocarnitine injection preparation apparatus of the present application comprises a drug mixing bin 100, a stirring and mixing assembly 200, a power assembly and a control unit.

As shown in fig. 1 and 2, the medicine mixing bin 100 is a mixing container configured with medicines, and functions to carry the stirring and mixing assembly 200, and includes an outer housing 110, an upper cover 120, a support frame 130, a conveying assembly 140, a medicine adding assembly 150, and a pumping assembly 160; the outer shell 110 is a container with an open top, and is preferably in a horn shape with a large top and a small bottom; the upper cover 120 is positioned on the outer shell 110, and is used for closing the space formed by the outer shell 110 and carrying the delivery assembly 140 and the drug adding assembly 150; the supporting frame 130 is a frame structure or a rod body, and is used for fixing the outer shell 110 on a horizontal ground or other equipment, so as to play a role in supporting and fixing; the conveying assembly 140 is positioned on the upper cover 120, is a combination of a pump, a pipeline and the like, is communicated with a raw material bin for injection (used for storing injection water for pharmacy) and a pumping assembly 160, and plays a role in conveying liquid, gas and energy (electricity) into the stirring and mixing assembly 200; the medicine adding assembly 150 is positioned on the upper cover 120, is communicated with a solid raw material bin (used for storing solid raw materials for pharmacy), and comprises a quantitative discharging assembly (material distributing and blocking mechanism) used for timely putting quantitative solid medicines into the medicine mixing bin 100 through an input port 121 on the upper cover 120; the pumping assembly 160 is a combination of a pump body, a valve body and a pipe, and is positioned at the bottom of the outer housing 110 to pump out the liquid in the medicine mixing bin 100 and deliver the liquid to the filtering bin or the delivery assembly 140.

As shown in fig. 3 and 4, the stirring and mixing assembly 200 is rotatably connected to the upper cover 120, and is used for uniformly mixing the liquid medicine in the medicine mixing bin 100 through rotation of the stirring and mixing assembly, and includes a central rotating rod 210 and a stirring rod 220; the central rotating rod 210 is rotatably connected to the upper cover 120 around its axis, is communicated with the conveying assembly 140, and comprises a hollow rod body 211 and a rod body rotation driving assembly 213; the hollow rod body 211 is tubular; the rod body rotation driving component 213 is preferably a combination of a motor, a gear and a gear ring because it drives the hollow rod body 211 to rotate around its own axis; the stirring rods 220 are multiple in number, are of a sleeve structure, and are fixed on the central rotating rod 210, and the included angle between the axis and the axis of the central rotating rod 210 is 30-90 degrees, and comprises an outer layer pipe 221 and an inner layer pipe 222; the end part of the outer layer pipe 221 far away from the central rotating rod 210 is closed and fixed on the inner layer pipe 222, a hollow cylindrical space exists between the outer layer pipe 221 and the inner layer pipe 222, and the gap between the outer layer pipe 221 and the inner layer pipe 222 is larger than 5 mm; the outer layer pipe 221 is densely distributed with water permeable holes 224 with through holes; the inner pipe 222 is tubular and is used for forming and outputting a water column with an axis coinciding with the axis of the stirring rod so as to assist in stirring, and the space and the hollow cylindrical space in the inner pipe 222 are communicated with the inner space of the central rotating rod 210; during stirring, the pumping assembly 160 cooperates with the conveying assembly 140 to pump the liquid in the drug mixing chamber 100 to the inner space of the central rotating rod 210, and the liquid is respectively output from the bottom of the hollow rod 211, the end of the inner tube 222 far away from the hollow rod 211, and the water permeable holes 224 on the outer tube 221 to perform accelerated stirring and mixing on the liquid drug.

Preferably, the hollow rod 211 has an inner space that is large at the top and small at the bottom for reducing the amount of liquid output from the bottom of the hollow rod 211 per unit time, so as to force a part of the liquid to flow to the stirring rod 220.

Preferably, as shown in fig. 5, a flow restriction plate 212 is fixed on an inner wall of the hollow rod 211 near the bottom, and the flow restriction plate 212 is an annular plate for decreasing the amount of liquid output from the bottom of the hollow rod 211 per unit time, thereby increasing the water pressure in the inner space of the hollow rod 211 and forcing a portion of the liquid to flow toward the stirring rod 220.

Preferably, the end of the inner tube 222 distal from the central rotating shaft 210 is also positioned with an annular restrictor plate 212.

The power component is used for providing power for the operation of each component of the levocarnitine injection configuration equipment, and the control unit plays a role in controlling the coordinated operation of each component of the levocarnitine injection configuration equipment, is the prior art, and is not repeated herein.

Preferably, the control unit is a combination of a programmable logic controller and a control key.

The preparation process of the levocarnitine injection comprises the following steps:

s1, weighing the water for injection and the levocarnitine (the step can be realized by the matching of the conveying component 140 and the medicine adding component 150);

s2, seventy-five percent of water for injection is injected into the medicine mixing bin 100 (this step can be realized by the conveying assembly 140);

s3, adding the levocarnitine with the formula amount, and uniformly stirring and mixing (the medicine adding component 150 is matched with the stirring and mixing component 200 to realize that the stirring speed is preferably 60rpm, and the time is preferably 5 min);

s4, adding quantitative hydrochloric acid, and adjusting the pH value of the liquid medicine to meet the intermediate control standard (the medicine adding component 150 is matched with the stirring and mixing component 200 to realize that the stirring speed is preferably 60rpm, and the time is preferably 5 min);

s5, adding water for injection to a constant volume (which can be carried out in the medicine mixing bin 100 or the filtering bin);

s6, filtering by using a filter membrane with the diameter of 0.45 mu m and the diameter of 0.22 mu m (detecting an intermediate product after filtering);

and S7, filling, sealing (leakage detection is needed), sterilizing, inspecting by lamp, packaging and finally performing full inspection.

When this application levocarnitine injection configuration equipment actually uses: when the stirring rod 220 stirs by rotating around the central rotating rod 210, the pumping assembly 160 cooperates with the conveying assembly 140 to pump the liquid to the inner space of the central rotating rod 210, and the liquid is respectively output from the bottom of the hollow rod 211 (improving the mixing efficiency of the liquid medicine at the bottom of the medicine mixing bin 100), the end of the inner tube 222 far away from the hollow rod 211 (increasing the flow of the liquid medicine) and the water permeable hole 224 on the outer tube 221 (increasing the flow of the liquid medicine), so as to improve the mixing effect and speed of the liquid medicine.

Mixing can also be accelerated by means of bubbles by letting gas through the central turning rod 210.

The technical scheme in the embodiment of the application at least has the following technical effects or advantages:

the technical problems that the mixing effect of liquid medicine in an area right below the central position of the stirring assembly is poor and the mixing efficiency of the configuration equipment to the liquid medicine is low due to the fact that the configuration equipment in the prior art is limited by the linear velocity of the rotation of the stirring rod part close to the rotating shaft are solved, and the technical effects that the mixing efficiency of the configuration equipment for the levocarnitine injection is high and the liquid medicine right below the central position of the stirring assembly can be efficiently mixed are achieved.

Example two

In order to further increase the mixing efficiency of the levocarnitine injection preparation device and shorten the preparation time and further reduce the production cost, the stirring rod rotating assembly 230 is additionally arranged on the basis of the embodiment of the present application, specifically:

as shown in fig. 4 to 10, the stirring rod rotating assembly 230 is used for driving the tilted stirring rod 220 to rotate around a direction perpendicular to the axial direction of the central rotating rod 210 so as to accelerate mixing, and comprises a bearing block 231, a rotating block 232 and a driving system 233; the bearing blocks 231 are fixed on the outer wall of the central rotating rod 210, correspond to the stirring rods 220 one by one, and are used for bearing the rotating blocks 232; the rotating block 232 is preferably tubular, and is rotatably connected to the bearing block 231, and the axial direction of the rotating shaft is perpendicular to the axial direction of the central rotating rod 210; the end part of the stirring rod 220 close to the central rotating rod 210 is fixed on the central rotating rod 210, and the angle between the stirring rod 220 and the central rotating rod 210 is 30-60 degrees; the inner space of the stirring rod 220 (i.e. the space in the inner tube 222 and the hollow cylindrical space) is communicated with the inner space of the central rotating rod 210 through a bearing block 231 and a rotating block 232; the driving system 233 is used for driving the rotating block 232 to rotate around the axis thereof.

Further, as shown in fig. 7 and 10, the driving system 233 is positioned inside the central rotating rod 210, and includes a central driving rod 234, a first gear ring 235 and a second gear ring 236; the central driving rod 234 is a combination of a motor and a rod body, is positioned on the upper cover 120, and rotates around the axis thereof under the control of the control unit; the number of the first gear ring 235 and the second gear ring 236 is the same as that of the stirring rods 220; the first ring gear 235 is fixed to the center drive rod 234 in the same axial direction as the center drive rod 234; the second gear ring 236 is fixed on the rotating block 232, the axis of the second gear ring is overlapped with the axis of the rotating block 232, and the second gear ring is meshed with the first gear ring 235; in actual use, the rotation of the central driving rod 234 drives the stirring rod 220 to rotate around the axis of the rotating block 232.

EXAMPLE III

Considering that a part of the liquid medicine is remained on the inner wall of the medicine mixing bin 100 and the stirring and mixing assembly 200 during the pharmaceutical process in the solution of the above embodiment, if the medicine mixing bin 100 is not continuously used, the medicine mixing bin 100 needs to be cleaned after use and before use, otherwise the pharmaceutical quality is easily affected by deterioration; in order to achieve the cleaning effect, the medicine mixing bin 100 is generally filled with clean water for rinsing, which seriously wastes water resources and takes long time; in order to solve the above problems, the embodiment of the present application adds the closing plate assembly 240 and the cleaning assembly 300 on the basis of the above embodiment; the method comprises the following specific steps:

as shown in fig. 10, the main body of the closed plate assembly 240 is a plate, and is used for controlling the water yield of the stirring rod 220 by blocking the water inlet under the control of the control unit, so as to control the water yield of the bottom of the central rotating rod 210; the closing plate assembly 240 comprises a closing plate 241, a positioning frame 242 and a plate body lifting assembly 243; the closing plates 241 correspond to the water inlets of the rotating blocks 232 one by one and are fixed on the positioning frame 242, and the positioning frame 242 is of a frame structure and is positioned inside the central rotating rod 210 and positioned on the upper cover 120; the plate lifting assembly 243 is preferably a telescopic rod structure, and is controlled by the control unit to drive the positioning frame 242 to move up and down so as to control the water output of the stirring rod 220.

As shown in fig. 11 to 14, the cleaning assembly 300 includes a water-extruded plate assembly 310 and a water curtain generation assembly 320; the position of the hollow rod body 211 close to the bottom is a special-shaped tube part 250, and the inner diameter of the special-shaped tube part 250 is larger than the inner diameters of other positions of the hollow rod body 211;

the water squeezing plate assembly 310 is used for controlling water outlet at the bottom of the central rotating rod 210 and comprises a positioning frame 311, a blocking plate 312, a force application pressure spring 313, a limiting ring 314, a lifting squeezing rod 315 and a support 317; the positioning frame 311 is of a frame structure, is fixed on the inner wall of the hollow rod body 211, is positioned above the special-shaped pipe part 250, and is used for positioning the force application pressure spring 313; the limiting ring 314 is annular, is fixed on the inner wall of the hollow rod body 211, is arranged close to the end part of the central rotating rod 210, is positioned below the special-shaped pipe part 250, and is used for bearing the blocking plate 312; the plugging plate 312 abuts against the limiting ring 314 and is used for plugging water flow; the force application compression spring 313 is positioned between the positioning frame 311 and the plugging plate 312 and is used for extruding the plugging plate 312; the lifting extrusion rod 315 is fixed on the inner wall of the medicine mixing bin 100 through a support 317, is a telescopic rod, is controlled by the control unit, and the top of the lifting extrusion rod is abutted against the bottom of the plugging plate 312; after the lifting extrusion rod 315 pushes the plugging plate 312 to move upwards, the plugging plate 312 enters the special-shaped pipe part 250, and the liquid in the central rotating rod 210 flows out from the bottom;

the water curtain generating assembly 320 is positioned right below the central rotating rod 210 and is used for forming the inner wall of the annular water curtain cleaning medicine mixing bin 100 and the stirring and mixing assembly 200, and comprises a water guide disc 321, a water guide blade 323 and a blade rotating assembly 324; the water guide disc 321 is fixed on the medicine mixing bin 100, is positioned right below the central rotating rod 210 and is in a disc shape, a water through hole 322 is positioned in the center of the water guide disc 321, the water through hole 322 is used for allowing the lifting extrusion rod 315 and part of liquid medicine output from the bottom of the central rotating rod 210 to pass through, and the diameter of the water through hole 322 is 2-5 cm larger than that of the lifting extrusion rod 315; the water guide blades 323 are arc-shaped sheet bodies, the number of the water guide blades 323 is 8 or more, the water guide blades are rotatably connected to the water guide disc 321 and are uniformly distributed on the periphery of the water guide disc 321, and the plurality of water guide discs 321 and the water guide blades 323 are combined to form a bowl shape; the blade rotating assembly 324 is used for controlling all the water guide blades 323 to rotate so as to change the size of the bowl mouth of the combination of the bowl-shaped water guide disc 321 and the water guide blades 323, and further change the direction of the water curtain. The water curtain can play a role in rinsing the container (avoiding waste of liquid medicine) in the constant volume process. In practical use, the blocking plate 312 is first pressed to move upwards, and then the closing plate assembly 240 operates to reduce the water output of the stirring rod 220, at this time, a part of the liquid output from the bottom of the central rotating rod 210 is output to the lower part of the water guide plate 321 through the water through holes 322, and another part of the liquid impacts the water guide plate 321 to form a water curtain.

Further, as shown in fig. 14, the blade rotating assembly 324 includes a force ring 325 and a force ring lifting assembly 326; the force applying ring 325 is sleeved on a ring formed by the water guide blades 323, and the force applying ring lifting assembly 326 is used for controlling the lifting of the force applying ring 325 so as to control the rotation of the water guide blades 323, and is preferably a telescopic rod controlled by a control unit.

Preferably, in order to expand the cleaning range and enhance the cleaning effect, as shown in fig. 13, a hole blocking block 316 is further fixed on the lifting extrusion rod 315, and the size of the hole blocking block 316 is slightly smaller than that of the water through hole 322, so as to block the water through hole 322 after the lifting extrusion rod 315 rises to a certain extent; as shown in fig. 15, the bin cleaning assembly 300 further includes a second water curtain generating assembly 330, the second water curtain generating assembly 330 has the same structure as the water curtain generating assembly 320 and is fixed on the upper cover 120, and the second water curtain generating assembly 330 and the water curtain generating assembly 320 are symmetrically arranged and controlled by the control unit. In actual use, the control unit firstly controls the hole blocking block 316 to block the water passing hole 322, and at the same time controls the bowl mouth of the combination of the bowl-shaped water guide disc 321 and the water guide vane 323 to be reduced, so that the water curtain is flushed towards the second water curtain generating assembly 330, and the second water curtain generating assembly 330 forms a new annular water curtain to further clean the medicine mixing bin 100.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A levocarnitine injection preparation device comprises a medicine mixing bin and a stirring and mixing assembly, wherein the medicine mixing bin comprises an outer shell, an upper cover, a conveying assembly, a medicine adding assembly and a pumping assembly; the method is characterized in that: the stirring and mixing component comprises a central rotating rod and a stirring rod;

the outer layer pipe is densely provided with water permeable holes;

2. The levocarnitine injection formulation apparatus of claim 1, wherein: the stirring rod rotating assembly is further included;

3. The levocarnitine injection dispensing apparatus of claim 1 or 2 wherein: also includes a closure panel assembly;

the sealing plates correspond to the water inlets of the rotating blocks one by one and are fixed on the positioning frame, and the positioning frame is of a frame structure, is positioned in the central rotating rod and is positioned on the upper cover;

4. The levocarnitine injection formulation apparatus of claim 3, wherein: the device also comprises a bin cleaning component;

the bin cleaning assembly comprises an extruded water plate assembly and a water curtain generating assembly; the position of the hollow rod body close to the bottom is a special-shaped pipe part, and the inner diameter of the special-shaped pipe part is larger than the inner diameters of other positions of the hollow rod body;

5. The levocarnitine injection formulation apparatus of claim 4, wherein: the blade rotating assembly comprises a force application ring and a force application ring lifting assembly;

6. The levocarnitine injection formulation apparatus of claim 4, wherein: a hole plugging block is also fixed on the lifting extrusion rod and used for plugging the water passing hole after the lifting extrusion rod rises to a certain degree;

7. The levocarnitine injection formulation apparatus of claim 1, wherein: the conveying assembly is positioned on the upper cover, is a combination of a pump and a pipeline, is communicated with the raw material bin for injection water and the pumping assembly, and plays a role in conveying liquid, gas and energy into the stirring and mixing assembly;

8. The levocarnitine injection formulation apparatus of claim 1, wherein: the inner wall of the hollow rod body close to the bottom is fixedly provided with a flow limiting plate which is an annular plate and is used for reducing the liquid amount output from the bottom of the hollow rod body in unit time.

9. The levocarnitine injection formulation apparatus of claim 2, wherein: the driving system is positioned inside the central rotating rod and comprises a central driving rod, a first gear ring and a second gear ring;

the number of the first gear rings and the number of the second gear rings are the same as the number of the stirring rods;

10. A preparation process of levocarnitine injection is characterized by comprising the following steps: matching the levocarnitine injection preparation device as claimed in claim 1, the steps are sequentially as follows:

s1, weighing water for injection and levocarnitine;

s2, seventy-five percent of water for injection is injected into the medicine mixing bin;

s3, adding the levocarnitine with the prescription amount, and stirring and mixing uniformly;

s4, adding quantitative hydrochloric acid, and adjusting the pH value of the liquid medicine to meet the intermediate control standard;

s5, adding water for injection to fix the volume;

s6, filtering by using a 0.45 mu m and 0.22 mu m filter membrane;

and S7, filling, sealing, sterilizing, inspecting by lamp, packaging and finally performing full inspection.