CN114870239B - Photo-medical device - Google Patents
Photo-medical device Download PDFInfo
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- CN114870239B CN114870239B CN202210460474.9A CN202210460474A CN114870239B CN 114870239 B CN114870239 B CN 114870239B CN 202210460474 A CN202210460474 A CN 202210460474A CN 114870239 B CN114870239 B CN 114870239B
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0653—Organic light emitting diodes
Abstract
The application discloses a photo-medical device, which comprises a substrate layer, a positive electrode layer or a negative electrode layer, a photo-functional layer, a negative electrode layer or a positive electrode layer and a packaging layer which are sequentially arranged; the positive electrode layer and the negative electrode layer are present at the same time; the photo-medical device emits light from one side of the substrate layer or one side of the packaging layer, and a drug layer is arranged on the light-emitting side of the photo-medical device; the photomedical device is also provided with an electric field forming structure comprising: the first lead-in electrode is arranged on the outer structure layer, and the outer structure layer is a substrate layer or a packaging layer; and the second lead-in electrode is opposite to the first lead-in electrode in polarity and is used for being attached to the photo-medical tissue. The device utilizes the device structure of the photo-medical device to construct and form a drug-introducing electric field, and realizes efficient drug introduction in the simplest form, thereby improving the treatment effect of the photo-medical device.
Description
Technical Field
The present disclosure relates generally to the field of photomedical technology, and more particularly to a photomedical device.
Background
An OLED is a photoelectric device that emits light by carrier injection and recombination of light. The specific process is that electrons are injected through a metal cathode, electrons are transmitted to a light-emitting layer through an electron transmission material, holes are injected through a metal anode, holes are transmitted to the light-emitting layer through a hole transmission material, the electrons and the holes are combined in the light-emitting layer to form excitons, and the excitons deactivate light. The OLED has the characteristics of good uniformity of light emission, light weight, flexibility, stretchability, etc. and at the same time, the OLED makes it easy to manufacture wearable photomedical devices.
The OLED light-emitting surface is usually coated with a drug layer or the affected part is coated with a drug layer, and the drug enters the body by diffusion. The photomedical efficiency in this way is low, and the present application is directed to an efficient photomedical device.
Disclosure of Invention
In view of the above-described drawbacks or shortcomings in the prior art, it is desirable to provide an photomedical device including a substrate layer, a positive electrode layer or negative electrode layer, a photofunctional layer, a negative electrode layer or positive electrode layer, a packaging layer, which are disposed in that order; the positive electrode layer and the negative electrode layer are present at the same time; the photo-medical device emits light from one side of the substrate layer or one side of the packaging layer, and a drug layer is arranged on the light-emitting side of the photo-medical device; the photomedical device is also provided with an electric field forming structure comprising:
the first lead-in electrode is arranged on the outer structure layer, and the outer structure layer is a substrate layer or a packaging layer;
a second lead-in electrode, opposite in polarity to the first lead-in electrode, for attachment to a photomedical tissue;
the photomedical device forms an electric field for drug delivery by supplying power to the first and second delivery electrodes.
According to the technical scheme provided by the embodiment of the application, the material of the outer structural layer is a conductive material; the outer structural layer forms the first lead-in electrode; an insulating layer is arranged on one side of the outer structure layer, which is close to the optical function layer; when the photomedical device emits light from one side of the outer structural layer, the outer structural layer is made of a transparent material that can transmit light.
According to the technical scheme provided by the embodiment of the application, the material of the outer structural layer is an insulating material, and a conductive layer is formed on the surface of the outer structural layer; the conductive layer forms the first lead-in electrode; an insulating material is arranged on one side of the conductive layer, which is close to the optical functional layer; when the photomedical device emits light from one side of the outer structure layer, the conductive layer is made of transparent material capable of transmitting light or a light hole is formed on the conductive layer.
According to the technical scheme provided by the embodiment of the application, the photo-medical device independently supplies power to the photo-functional layer and the electric field.
According to the technical scheme provided by the embodiment of the application, the photomedical device alternately supplies power to the photomechanical layer and the electric field.
According to the technical scheme provided by the embodiment of the application, the outer structural layer is electrically connected with the positive electrode layer or the negative electrode layer, and the photomedical device alternately supplies power to the photomechanical layer and the electric field through the control circuit.
According to the technical scheme provided by the embodiment of the application, an isolation layer is arranged on one side of the outer structure layer, which is close to the medicine layer, and the isolation layer is made of at least one of indium tin oxide paint or aerogel; the spacer layer is preferably doped with scattering particles.
According to the technical scheme provided by the embodiment of the application, one side of the substrate layer, which is close to the optical function layer, is provided with a first water-resisting layer; the first water-resistant layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the first water-resistant layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering.
According to the technical scheme provided by the embodiment of the application, a second water-resistant layer is arranged between the packaging layer and the optical function layer, and the second water-resistant layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the second water-resistant layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering.
According to the technical scheme provided by the embodiment of the application, a barrier adhesive layer is arranged between the packaging layer and the optical functional layer, and the barrier adhesive layer is composed of at least one of polyolefin and rubber; the barrier adhesive layer is doped with a water absorbing material.
According to the technical scheme provided by the embodiment of the application, the exposed part of the outer structural layer is wrapped with the insulating material.
According to the technical scheme provided by the embodiment of the application, the medicine layer is a gel doped with medicine, and ions are doped in the gel.
According to the technical scheme, the first lead-in electrode is arranged on the outer structure layer (the packaging layer or the substrate layer) of the photo-medical device, the second lead-in electrode with the polarity opposite to that of the first lead-in electrode is arranged, and the electric field for introducing the medicine is formed by supplying power to the first lead-in electrode and the second lead-in electrode, so that the establishment of the electric field is realized on the premise of not changing and increasing the device structure of the photo-medical device, the medicine in the medicine layer is further accelerated to be introduced into the body, and the curative effect of the photo-medical device is improved; the device utilizes the device structure of the photo-medical device to construct and form a drug-introducing electric field, and realizes efficient drug introduction in the simplest form, thereby improving the treatment effect of the photo-medical device.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the detailed description of non-limiting embodiments, made with reference to the accompanying drawings in which:
fig. 1 is a schematic structural diagram of a first device structure in embodiment 1;
fig. 2 is a schematic structural diagram of a second device structure in embodiment 1;
fig. 3 is a schematic structural diagram of a third device structure in embodiment 1;
fig. 4 is a schematic structural diagram of a fourth device structure in embodiment 1;
fig. 5 and 6 are schematic diagrams of a power supply circuit in embodiment 1;
fig. 7 and 8 are schematic diagrams of another power supply circuit in embodiment 1;
fig. 9 is a schematic structural view of a fifth device structure in embodiment 1;
fig. 10 is a schematic structural view of a sixth device structure in embodiment 1;
fig. 11 is a schematic structural view of a seventh device structure in embodiment 1;
fig. 12 is a schematic structural view of an eighth device structure in embodiment 1;
fig. 13 is a schematic structural view of a ninth device structure in embodiment 1;
fig. 14 and 15 are schematic structural views of the drug layer in example 1;
fig. 16 and 17 are schematic structural views of two device structures in embodiment 2;
fig. 18 and 19 are schematic diagrams of a power supply circuit in embodiment 2;
fig. 20 and 21 are schematic diagrams of the structure of another power supply circuit in embodiment 2;
reference numerals in the drawings:
10. a substrate layer; 20. a positive electrode layer; 30. a negative electrode layer; 40. an optical functional layer; 30. a negative electrode layer; 50. an encapsulation layer; 60. a drug layer; 70. a second lead-in electrode; 80. a photo-medical organization 80; 91. a first power supply circuit; 92, a second power supply circuit; 93, a first power supply end, 94, a second power supply end; 95. a control circuit; 100. an isolation layer; 110. a first water blocking layer; 120. a second water blocking layer; 130. and a barrier adhesive layer.
Detailed Description
The application is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be noted that, for convenience of description, only the portions related to the application are shown in the drawings.
It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other. The application will be described in detail below with reference to the drawings in connection with embodiments.
Example 1
The present embodiment provides a photomedical device including a substrate layer 10, a positive electrode layer 20 or a negative electrode layer 30, a photo-functional layer 40, a negative electrode layer 30 or a positive electrode layer 20, a packaging layer 50, which are disposed in this order; the positive electrode layer 20 and the negative electrode layer 30 coexist; the light medical device emits light from the substrate layer 10 side or the packaging layer 50 side, and the light emitting side of the light medical device is provided with a medicine layer 60; the photomedical device is also provided with an electric field forming structure comprising:
the first lead-in electrode is arranged on the outer structure layer, and in the embodiment, the outer structure layer is a packaging layer;
a second lead-in electrode 70, opposite in polarity to the first lead-in electrode, for attachment to the photomedical tissue 80;
the photomedical device forms an electric field for drug delivery by supplying power to the first and second delivery electrodes.
As shown in fig. 1 to fig. 4, the photomedical apparatus in this embodiment may be a bottom light emitting device or a top light emitting device, and the specific layer structure of each device may be as follows:
1. as shown in fig. 1, the method comprises the following steps in order from the lower part to the upper part in the figure: a drug layer 60, a substrate layer 10, a positive electrode layer 20, a light functional layer 40, a negative electrode layer 30, an encapsulation layer 50; the device emits light from the side of the substrate layer 10 (direction of arrow in the figure), and the drug layer 60 is intended to be in contact with the skin;
2. as shown in fig. 2, the method comprises the following steps, in order from the lower part to the upper part: a substrate layer 10, a positive electrode layer 20, a light functional layer 40, a negative electrode layer 30, an encapsulation layer 50, a drug layer 60; the device emits light from the side of the encapsulation layer 50 (direction of arrow in the figure), and the drug layer 60 is intended to be in contact with the skin;
3. as shown in fig. 3, the method comprises the steps of, in order from the bottom to the top in the drawing: a drug layer 60, a substrate layer 10, a negative electrode layer 30, a light functional layer 40, a positive electrode layer 20, an encapsulation layer 50; the device emits light from the side of the substrate layer 10 (direction of arrow in the figure), and the drug layer 60 is intended to be in contact with the skin;
4. as shown in fig. 4, the method includes, in order from the lower side to the upper side: a substrate layer 10, a negative electrode layer 30, a light functional layer 40, a positive electrode layer 20, an encapsulation layer 50, a drug layer 60; the device emits light from the side of the encapsulation layer 50 (direction of arrow in the figure) and the drug layer 60 is intended to be in contact with the skin.
Wherein the encapsulation layer 50 is electrically conductive, which is optionally implemented in any of the following ways:
in the mode a, the material of the encapsulation layer 50 is conductive material; the encapsulation layer serves as the first lead-in electrode; and an insulating layer is arranged on one side of the packaging layer close to the optical function layer. The encapsulation layer 50 may be, for example, in a metal sheet shape, for example, a metal foil, which is attached to an insulation layer formed on a side thereof adjacent to the light functional layer 40; the encapsulation layer 50 may be prepared on the insulating layer on the side thereof near the light functional layer 40 by, for example, evaporation, spin coating, sputtering, screen printing, ink-jet printing, or the like; the material of the encapsulation layer 50 may be, for example, a metal such as titanium, aluminum, copper, iron, or a metal alloy or nano-metal, which acts as a barrier to water and oxygen and as a first lead-in electrode, which forms an electric field with the skin after voltage is applied, allowing the drug to migrate into the body.
The outer structural layer (i.e., the encapsulation layer 50) is made of a transparent material that is transparent to light when the photomedical device emits light from the encapsulation layer 50 side. The material may be, for example, PEDOT: PSS [ fully known as poly-3, 4-ethylenedioxythiophene: polystyrene sulfonate is mixed into an organic material to form a conductive material.
In some embodiments of the present application, as shown in fig. 13, the insulating layer on the side of the encapsulation layer 50 near the optical functional layer includes a second water-blocking layer 120 and a barrier adhesive layer 130;
the second water blocking layer 120 is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy, or polyolefin; the second water-blocking layer 120 is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering. The second water blocking layer 120 is used for blocking water and oxygen, and can improve the packaging and water and oxygen resistance of the photo-medical device and prolong the service life.
The barrier adhesive layer 130 is composed of at least one of polyolefin and rubber; the barrier adhesive layer is doped with a water absorbing material, and the water absorbing material can be calcium oxide or barium oxide and other materials.
In some embodiments of the present application, as shown in fig. 12, the insulating layer on the side of the encapsulation layer 50 adjacent to the light functional layer includes only the second water blocking layer 120. In this case, if the encapsulation layer 50 is a whole metal layer, it may not only function as the first lead-in electrode or the second lead-in electrode, but also further function as a water-oxygen barrier.
In the mode b, the packaging layer 50 is made of an insulating material, and a conductive layer is formed on the surface of the packaging layer; the encapsulation layer 50 is, for example, a barrier film, and the conductive layer may be, for example, in a metal sheet shape, and is formed by adhering to the barrier film; the conductive layer can be prepared on the barrier film by evaporation, spin coating, sputtering, screen printing, ink-jet printing and the like; the conductive layer serves as the first lead-in electrode; the insulating layer is disposed on a side of the conductive layer, which is close to the optical functional layer, and the insulating layer may be, for example, a barrier film itself, or may further include a second water-blocking layer 120, or further include the second water-blocking layer 120 and a barrier adhesive layer 130.
Wherein the power supply design of the photomedical device can be selected from any one of the following modes:
mode one: the optical medical device independently supplies power to the optical functional layer and the electric field, and as shown in fig. 1 to 4, a control circuit of the optical medical device includes a first power supply circuit 91 and a second power supply circuit 92; two power supply ends of the first power supply circuit 91 are respectively connected with the positive electrode layer and the negative electrode layer; the two power supply ends of the second power supply circuit 92 are electrically connected to the first lead-in electrode and the second lead-in electrode 70, respectively.
In the embodiment, the photo-medical device is an OLED, the OLED is provided with fpc and fpc for leading out power supply lines of the positive electrode layer and the negative electrode layer and is used for being connected with a control module of the OLED, and the control module is used for adjusting and controlling the on-off and the light-emitting brightness of the OLED by applying power supply signals to the positive electrode layer and the negative electrode layer;
the first power supply circuit supplies power to the positive electrode layer and the negative electrode layer through the FPC to light the OLED, so that the OLED emits light for treatment; the first power supply circuit is an integrated circuit disposed within the control module.
In this embodiment, a second power supply circuit is added to the control module of the photomedical device, and the second power supply circuit is used for supplying power to the first lead-in electrode and the second lead-in electrode, and the second lead-in electrode 70 can be attached to the skin of the human body; for example, a circuit connected with the conductive part of the packaging layer is added on the FPC, and after the second power supply circuit is communicated with a power supply, the packaging layer and the skin form an electric field so that the medicine is migrated into the body; the medicine is absorbed by the skin more, so that the curative effect of phototreatment and medicine is more obvious. The second power supply circuit may be a separately provided circuit or may be a circuit integrated within the photomedical device control module.
Mode two: on the basis of the first embodiment, the photomedical apparatus alternately supplies power to the photomechanical layer and the electric field, that is, the first power supply circuit 91 and the second power supply circuit 92 alternately supply power. When both the first power supply circuit 91 and the second power supply circuit 92 are supplied with power by an integrated circuit integrated within a control chip of the photomedical apparatus, then switching of the first power supply circuit 91 and the second power supply circuit 92 can be achieved by setting a control program of the integrated circuit.
This approach is preferably applicable to the case shown in fig. 1 and 3, where the electric field for drug introduction crosses the various device layers of the OLED, and the operating circuit of the OLED and the electric field circuit for drug introduction are operated separately, so that the effect of the electric field for drug introduction on the operation of the OLED can be avoided.
Mode three: as shown in fig. 5 and 6, the first lead-in electrode is electrically connected to the positive electrode layer 20; i.e., the conductive portion of the encapsulation layer is connected to the positive electrode layer 20; the optical medical device alternately supplies power to the optical functional layer and the electric field through a control circuit; the switching of the control circuit can be realized by setting a control program of the integrated circuit, and the control circuit is the integrated circuit in the control chip. The control chip can be a single chip microcomputer or an ARM controller, for example.
The power supply circuit of the photomedical device includes a first power supply terminal 93 and a second power supply terminal 94 having opposite electric polarities, the first power supply terminal 93 being electrically connected to the positive electrode layer 20, and the second power supply terminal 94 being alternately electrically connected to the second lead-in electrode 70 and the negative electrode layer 30. In the present embodiment, the switching of the connection state of the second power supply terminal 94 is achieved by the control circuit 95, and when the second power supply terminal 94 is connected to the second introduction electrode 70, a drug introduction electric field is formed between the positive electrode layer connected to the encapsulation layer and the human tissue 80; when the second power supply terminal 94 is electrically connected to the negative electrode layer 30, the photo-functional layer of the photo-medical device operates and emits light for photo-medical treatment. The mode not only realizes the power supply of the two functional circuits, but also realizes the switching work of the two functional circuits, and avoids the mutual influence.
When the light functional layer works, for example, the power supply current is 100mA, and the power supply current is 10mA when the medicine is introduced into an electric field to work; the control chip of the photo-medical device can realize the adjustment of the power supply current when different power supply circuits work.
Mode four: as shown in fig. 7 and 8, the first lead-in electrode is electrically connected to the negative electrode layer 30; i.e., the conductive portion of the encapsulation layer is connected to the negative electrode layer 30; the optical medical device alternately supplies power to the optical functional layer and the electric field through a control circuit; the power supply circuit of the photomedical device includes a first power supply terminal 93 and a second power supply terminal 94 having opposite electric polarities, the first power supply terminal 93 being electrically connected to the negative electrode layer 30, and the second power supply terminal 94 being alternately electrically connected to the second lead-in electrode 70 and the positive electrode layer 20.
In the present embodiment, the switching of the connection state of the second power supply terminal 94 is achieved by the control circuit 95, and when the second power supply terminal 94 is connected to the second introduction electrode 70, a drug introduction electric field is formed between the negative electrode layer connected to the encapsulation layer and the human tissue 80; when the second power supply terminal 94 is electrically connected to the positive electrode layer 20, the photo-functional layer of the photo-medical device operates to emit light for photo-medical treatment. The mode not only realizes the power supply of the two functional circuits, but also realizes the switching work of the two functional circuits, and avoids the mutual influence.
When the power supply is needed to be described, in the mode, when different functional circuits work, the power supply current direction of the power supply circuit can be different, and the positive electrode layer is ensured to be always connected with the positive electrode of the power supply through the switching of the power supply voltage, so that the negative electrode layer is always connected with the negative electrode of the power supply; when different functional circuits work, the power supply current of the power supply circuit can be different.
In certain embodiments of the present application, wherein the drug layer is an ionizable drug, the drug layer is capable of moving with an electric field under the influence of the electric field; for example, the drug layer is a gel doped with a drug, which is directly dissociated under an electric field, and then drug ions follow the electric field. For example, potassium chloride (potassium ion is cation) can be introduced to improve excitability of neuromuscular, and can be used for treating peripheral neuritis and nerve paralysis. For another example, the introduction of the Chinese medicine radix Aconiti Kusnezoffii (containing alkaloid as main ingredient) can treat joint pain and nerve pain caused by hyperosteogeny. The most common method for treating hyperosteogeny is to take edible vinegar (the main component of the edible vinegar is acetic acid and contains anions) as an imported medicine. Under the action of an electric field, acetate ions enter the body through skin and interact with calcium ions on bones to reduce calcium salt deposition, diminish inflammation and relieve pain, and at the same time, the photo-medical treatment can also diminish inflammation and relieve pain, so that the aim of treating hyperosteogeny is achieved under the synergistic effect.
The power supply circuit supplies power to the electric field according to the characteristics of ions in the medicine layer, if the ions in the medicine layer are cations, the second leading-in electrode for being attached to the skin of the human body is an anode, the anode of the power supply is connected, the first leading-in electrode opposite to the anode is a cathode, and the cathode of the power supply is connected. If the electric ions in the medicine layer are anions, the second leading-in electrode for being attached to the skin of the human body is a cathode, the cathode of the power supply is connected, and the first leading-in electrode opposite to the second leading-in electrode is an anode, and the anode of the power supply is connected.
In some embodiments of the present application, as shown in fig. 10, when the light emitting direction of the photomedical device is located at one side of the encapsulation layer, the encapsulation layer 50 is provided with an isolation layer 100 at a side relatively close to the drug layer; as shown in fig. 11, when the light emitting direction of the photomedical device is located on the side of the substrate layer 10, the side of the substrate layer 10 relatively close to the medicine layer 60 is provided with an isolation layer 100; the isolation layer 100 is made of at least one of indium tin oxide paint or aerogel; the spacer layer 100 is preferably doped with scattering particles. The isolation layer 100 is used for isolating and improving the light emission of the OLED, and is made of indium tin oxide paint, aerogel, etc., and is mixed with scattering particles, such as titanium oxide. Meanwhile, the isolation layer 100 may serve as an insulating layer between the isolation outer structural layer and the medicine layer.
In some embodiments of the present application, as shown in fig. 11, a first water-blocking layer 110 is disposed on a side of the substrate layer 10 relatively close to the optical functional layer 40; the first water blocking layer 110 is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the water-resistant layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering. The first water blocking layer 110 is used for blocking water and oxygen, so that the packaging and water and oxygen resistance of the photo-medical device can be improved, and the service life of the photo-medical device can be prolonged.
In certain embodiments of the present application, as shown in fig. 14-15, the drug layer portions are spaced to cover the light-emitting side of the photomedical device; the medicine layer 60 is designed in a gridding or graphic manner, so that the light emitted from the photomedical device can illuminate more from the space between the medicine layers, and the photomedical effect is further improved.
In some embodiments of the present application, the material of the positive electrode layer includes, for example, ITO and/or IZO, and the photo-functional layer includes a hole injection layer, a hole transport layer, an electron blocking layer, a light emitting layer, a hole blocking layer, and an electron blocking layer, which are sequentially stacked; the material of the negative electrode layer includes Ag and/or Al.
Example two
This embodiment differs from embodiment 1 in that: the first lead-in electrode is arranged on the substrate layer, in particular, the substrate layer 10 is provided with a conductive structure, and the structure of the substrate layer 10 can be realized by the following modes:
mode one: the substrate layer 10 is made of conductive material; for example, the light-blocking layer is a metal foil, and one side of the light-blocking layer, which is close to the light-functional layer, is provided with an insulating layer, for example, a first water-blocking layer; the substrate layer serves as the first lead-in electrode.
The outer structural layer (i.e., the substrate layer) is made of a transparent material that is light transmissive when the photomedical device emits light from the substrate layer side. The material may be, for example, PEDOT: PSS [ fully known as poly-3, 4-ethylenedioxythiophene: polystyrene sulfonate is mixed into an organic material to form a conductive material.
Mode two: the substrate layer 10 comprises a base material and a metal layer, wherein the base material is an organic polymer such as PET, PEN, PI, the metal layer is prepared by means of evaporation, spin coating, sputtering, screen printing, ink-jet printing and the like, and the metal layer is made of metals such as titanium, aluminum, copper, iron or metal alloy or nano-metals.
When the photomedical device emits light from the side of the substrate layer, the metal layer has a light transmittance of greater than 50%, and serves as a barrier to water and oxygen and as a drug-introducing electrode, and the metal layer in the substrate layer 10 is located on the side of the substrate remote from the light-functional layer.
The third mode, the substrate layer 10 includes a base material, a metal layer and an insulating layer, the base material is an organic polymer such as PET, PEN, PI, the metal layer is prepared by evaporation, spin coating, sputtering, screen printing, ink-jet printing and other modes, and the material of the metal layer is a metal such as titanium, aluminum, copper, iron or metal alloy or nano metal.
When the photomedical device emits light from the substrate layer side, the metal layer, which serves as a barrier to water and oxygen and as a drug-introducing electrode, has a light transmittance of more than 50%, and is located between the substrate and the insulating layer, which may be the first water blocking layer in the first embodiment, on the side close to the light functional layer 40.
In this embodiment, compared with embodiment 1, an induced electric field for realizing the drug layer is formed between the substrate layer and the human body, or between the conductive layer attached to the substrate layer and the human body.
As shown in fig. 16 and 17, the present embodiment is applicable not only to an OLED device that emits light from the side of the substrate layer 10, but also to an OLED device that emits light from the side of the encapsulation layer 50.
As shown in fig. 16 and 17, the two functional circuits (the electric field circuit for introducing the medicine and the circuit for operating the OLED device) in this embodiment can be powered by the second power supply circuit 92 and the first power supply circuit 91, respectively, so that two processes of phototherapy and medicine introduction can be simultaneously realized, and the therapeutic effect is better.
As shown in fig. 18 to 21, in this embodiment, as in embodiment 1, the two functional circuits are shared, and the two functional circuits are alternately operated by the control circuit, so that on one hand, the situation that the medicine introducing electric field passes through the OLED device to cause mutual influence can be avoided, and on the other hand, the circuit structure is simplified.
The above description is only illustrative of the preferred embodiments of the present application and of the principles of the technology employed. It will be appreciated by persons skilled in the art that the scope of the application referred to in the present application is not limited to the specific combinations of the technical features described above, but also covers other technical features formed by any combination of the technical features described above or their equivalents without departing from the inventive concept. Such as the above-mentioned features and the technical features disclosed in the present application (but not limited to) having similar functions are replaced with each other.
Claims (10)
1. The photo-medical device is characterized by comprising a substrate layer, a positive electrode layer or a negative electrode layer, a photo-functional layer, a negative electrode layer or a positive electrode layer and a packaging layer which are sequentially arranged; the positive electrode layer and the negative electrode layer are present at the same time; the photo-medical device emits light from one side of the substrate layer or one side of the packaging layer, and a drug layer is arranged on the light-emitting side of the photo-medical device; the photomedical device is also provided with an electric field forming structure comprising:
the first lead-in electrode is arranged on the outer structure layer, and the outer structure layer is a substrate layer or a packaging layer;
a second lead-in electrode, opposite in polarity to the first lead-in electrode, for attachment to a photomedical tissue;
the photomedical device forms an electric field for drug infusion by supplying power to the first and second infusion electrodes;
an isolation layer is arranged between the outer structure layer and the drug layer, and serves as an insulation layer for isolating the outer structure layer from the drug layer.
2. The photomedical device of claim 1, wherein the outer structural layer is a conductive material; the outer structural layer forms the first lead-in electrode; an insulating layer is arranged on one side of the outer structure layer, which is close to the optical function layer; when the photomedical device emits light from one side of the outer structural layer, the outer structural layer is made of a transparent material that can transmit light.
3. The photomedical apparatus according to claim 1, wherein the outer structural layer is made of an insulating material, and a conductive layer is formed on the surface thereof; the conductive layer forms the first lead-in electrode; an insulating material is arranged on one side of the conductive layer, which is close to the optical functional layer; when the photomedical device emits light from one side of the outer structure layer, the conductive layer is made of transparent material capable of transmitting light or a light hole is formed on the conductive layer.
4. The photomedical device of claim 1, wherein the photomedical device independently powers the photomechanical layer and the electric field, respectively, or wherein the photomedical device alternately powers the photomechanical layer and the electric field.
5. The photomedical device of claim 1, wherein the outer structural layer is electrically connected to the positive electrode layer or the negative electrode layer, the photomedical device alternately powering the photofunctional layer and the electric field through a control circuit.
6. The photomedical apparatus according to any one of claims 1 to 5, wherein an isolation layer is provided on a side of the outer structure layer adjacent to the drug layer, and the isolation layer is made of at least one of indium tin oxide paint and aerogel; scattering particles are doped in the isolation layer.
7. The photomedical device of any one of claims 1 to 5, wherein a first water-resistant layer is provided on a side of said substrate layer adjacent to said light functional layer; the first water-resistant layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the first water-resistant layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering.
8. The photomedical device of any one of claims 1 to 5, wherein a second water barrier layer is provided between the encapsulation layer and the photofunctional layer, the second water barrier layer being comprised of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy, or polyolefin; the second water-resistant layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering.
9. The photomedical apparatus according to any one of claims 1 to 5, wherein a barrier adhesive layer is provided between the encapsulation layer and the photofunctional layer, the barrier adhesive layer being composed of at least one of polyolefin and rubber; the barrier adhesive layer is doped with a water absorbing material.
10. The photomedical device of any one of claims 1-5, wherein the exposed portion of the outer structural layer is wrapped with an insulating material; the medicine layer is gel doped with medicine.
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