CN114870239A - Optical medical device - Google Patents

Optical medical device Download PDF

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Publication number
CN114870239A
CN114870239A CN202210460474.9A CN202210460474A CN114870239A CN 114870239 A CN114870239 A CN 114870239A CN 202210460474 A CN202210460474 A CN 202210460474A CN 114870239 A CN114870239 A CN 114870239A
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layer
photomedical
electrode
lead
electric field
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CN202210460474.9A
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CN114870239B (en
Inventor
康建喜
朱映光
鲁天星
郭立雪
张国辉
胡永岚
陈旭
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Guan Yeolight Technology Co Ltd
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Guan Yeolight Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0653—Organic light emitting diodes

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electroluminescent Light Sources (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

The application discloses a photomedical device, which comprises a substrate layer, a positive electrode layer or a negative electrode layer, a photofunctional layer, a negative electrode layer or a positive electrode layer and a packaging layer which are arranged in sequence; the positive electrode layer and the negative electrode layer exist at the same time; the light-emitting side of the photomedical device is provided with a medicine layer; the photomedical device is also provided with an electric field forming structure that includes: the first lead-in electrode is arranged on an outer structure layer, and the outer structure layer is a substrate layer or a packaging layer; and the second lead-in electrode has the opposite polarity to the first lead-in electrode and is used for being attached to the photomedical tissue. The device constructs and forms a drug introduction electric field by using the device structure of the optical medical device, realizes efficient drug introduction in the simplest form, and further improves the treatment effect of the optical medical device.

Description

Optical medical device
Technical Field
The present disclosure relates generally to the field of photomedical technology, and in particular, to a photomedical device.
Background
An OLED is a photoelectric device that emits light by carrier injection and recombination light emission. The specific process is that electrons are injected through a metal cathode and are transmitted to a light-emitting layer through an electron transmission material, holes are injected through a metal anode and are transmitted to the light-emitting layer through a hole transmission material, the electrons and the holes are combined in the light-emitting layer to form excitons, and the excitons are de-excited to emit light. The OLED has the characteristics of good light emitting uniformity, lightness, thinness, flexibility, stretchability and the like, and is concerned about, and meanwhile, the characteristics of the OLED enable the OLED to be easily used for manufacturing wearable photomedical equipment.
Usually, a drug layer is coated on the light-emitting surface of the OLED or coated on the affected part, and the drug enters the body through diffusion. The efficiency of the photomedical treatment in this way is low, and the invention aims to invent a high-efficiency photomedical device.
Disclosure of Invention
In view of the above-mentioned drawbacks and deficiencies of the prior art, it is desirable to provide a photomedical device including a substrate layer, a positive or negative electrode layer, a photofunctional layer, a negative or positive electrode layer, and an encapsulation layer, which are sequentially disposed; the positive electrode layer and the negative electrode layer exist at the same time; the light-emitting side of the photomedical device is provided with a medicine layer; the photomedical device is also provided with an electric field forming structure that includes:
the first lead-in electrode is arranged on an outer structure layer, and the outer structure layer is a substrate layer or a packaging layer;
the second lead-in electrode has opposite polarity to the first lead-in electrode and is used for being attached to the photomedical tissue;
the photomedical device forms an electric field for drug introduction by powering the first and second introduction electrodes.
According to the technical scheme provided by the embodiment of the application, the outer structure layer is made of a conductive material; the outer structural layer forms the first lead-in electrode; an insulating layer is arranged on one side, close to the optical function layer, of the outer structure layer; when the optical medical device emits light from one side of the outer structure layer, the outer structure layer is made of transparent material which can transmit light.
According to the technical scheme provided by the embodiment of the application, the outer structure layer is made of an insulating material, and a conductive layer is formed on the surface of the outer structure layer; the conductive layer forms the first lead-in electrode; an insulating material is arranged on one side, close to the optical function layer, of the conductive layer; when the light medical device emits light from one side of the outer structure layer, the conducting layer is made of transparent materials which can transmit light or light holes are formed in the conducting layer.
According to the technical scheme provided by the embodiment of the application, the optical medical device independently supplies power to the optical functional layer and the electric field respectively.
According to the technical scheme provided by the embodiment of the application, the optical medical device supplies power to the optical functional layer and the electric field alternately.
According to the technical scheme provided by the embodiment of the application, the outer structure layer is electrically connected with the positive electrode layer or the negative electrode layer, and the optical medical device alternately supplies power to the optical function layer and the electric field through the control circuit.
According to the technical scheme provided by the embodiment of the application, an isolation layer is arranged on one side of the outer structure layer close to the medicine layer, and the isolation layer is made of at least one of indium tin oxide paint or aerogel; the spacer layer is preferably doped with scattering particles.
According to the technical scheme provided by the embodiment of the application, a first water-resistant layer is arranged on one side, close to the optical function layer, of the substrate layer; the first water resisting layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the first water-blocking layer is prepared by at least one method of ALD, PECVD, IJP, screen printing or sputtering.
According to the technical scheme provided by the embodiment of the application, a second water-resistant layer is arranged between the packaging layer and the optical function layer, and the second water-resistant layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the second water-resistant layer is prepared by at least one method of ALD, PECVD, IJP, screen printing or sputtering.
According to the technical scheme provided by the embodiment of the application, a blocking adhesive layer is arranged between the packaging layer and the optical function layer and is composed of at least one of polyolefin and rubber; and the water absorption material is doped in the blocking adhesive layer.
According to the technical scheme provided by the embodiment of the application, the exposed part of the outer structure layer is wrapped with an insulating material.
According to the technical scheme provided by the embodiment of the application, the medicine layer is a gel doped with medicine, and ions are doped in the gel.
According to the technical scheme, the first lead-in electrode is arranged on the outer structure layer (the packaging layer or the substrate layer) of the optical medical device, the second lead-in electrode with the opposite polarity to that of the first lead-in electrode is arranged, and the first lead-in electrode and the second lead-in electrode are supplied with power to form an electric field for introducing the medicine, so that the establishment of the electric field is realized on the premise of not changing and increasing the device structure of the optical medical device, the medicine introduction in the medicine layer is accelerated, and the curative effect of the optical medical device is improved; the device constructs and forms a drug introduction electric field by using the device structure of the optical medical device, realizes efficient drug introduction in the simplest form, and further improves the treatment effect of the optical medical device.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the following detailed description of non-limiting embodiments thereof, made with reference to the accompanying drawings in which:
fig. 1 is a schematic structural diagram of a first device structure in embodiment 1;
fig. 2 is a schematic structural diagram of a second device structure in embodiment 1;
FIG. 3 is a schematic structural view of a third device structure in example 1;
FIG. 4 is a schematic structural view of a fourth device structure in example 1;
fig. 5 and fig. 6 are schematic structural views of a power supply circuit in embodiment 1;
fig. 7 and 8 are schematic structural views of another power supply circuit in embodiment 1;
fig. 9 is a schematic structural diagram of a fifth device structure according to embodiment 1;
fig. 10 is a schematic structural diagram of a sixth device structure according to embodiment 1;
fig. 11 is a schematic structural view of a seventh device structure according to embodiment 1;
FIG. 12 is a schematic structural view of an eighth device structure in example 1;
fig. 13 is a schematic structural view of a ninth device structure according to embodiment 1;
fig. 14 and 15 are schematic views of the structures of the drug layers in example 1;
fig. 16 and 17 are schematic structural views of two device structures in example 2;
fig. 18 and 19 are schematic structural views of a power supply circuit in embodiment 2;
fig. 20 and 21 are schematic structural views of another power supply circuit in embodiment 2;
reference numbers in the figures:
10. a substrate layer; 20. a positive electrode layer; 30. a negative electrode layer; 40. a light functional layer; 30. a negative electrode layer; 50. a packaging layer; 60. a drug layer; 70. a second lead-in electrode; 80. a photomedical tissue 80; 91. a first power supply circuit; 92, a second power supply circuit; 93, a first power supply terminal, 94, a second power supply terminal; 95. a control circuit; 100. an isolation layer; 110. a first water resistant layer; 120. a second water resistant layer; 130. and (4) a barrier adhesive layer.
Detailed Description
The present application will be described in further detail with reference to the following drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
Example 1
The embodiment provides a photomedical device, which comprises a substrate layer 10, a positive electrode layer 20 or a negative electrode layer 30, a photofunctional layer 40, a negative electrode layer 30 or a positive electrode layer 20 and an encapsulation layer 50 which are arranged in sequence; the positive electrode layer 20 and the negative electrode layer 30 exist at the same time; the light of the photomedical device is emitted from one side of the substrate layer 10 or one side of the packaging layer 50, and the light emitting side of the photomedical device is provided with a medicine layer 60; the photomedical device is also provided with an electric field forming structure that includes:
a first lead-in electrode disposed on the outer structure layer, which is an encapsulation layer in this embodiment;
a second lead-in electrode 70 having a polarity opposite to that of the first lead-in electrode and attached to the photomedical tissue 80;
the photomedical device forms an electric field for drug introduction by powering the first and second introduction electrodes.
As shown in fig. 1 to 4, the photomedical device in this embodiment may be a bottom emission device or a top emission device, and the specific structure of each device layer may be as follows:
1. as shown in fig. 1, the present invention includes, in order from the bottom to the top in the figure: a drug layer 60, a substrate layer 10, a positive electrode layer 20, a photo-functional layer 40, a negative electrode layer 30, and an encapsulation layer 50; the device emits light (in the direction of the arrow in the figure) from the substrate layer 10 side, and the drug layer 60 is intended to be in contact with the skin;
2. as shown in fig. 2, the present invention includes, in order from the bottom to the top in the drawing: a substrate layer 10, a positive electrode layer 20, a photofunctional layer 40, a negative electrode layer 30, an encapsulation layer 50, a drug layer 60; the device emits light from the side of the encapsulation layer 50 (in the direction of the arrows in the figure), and the drug layer 60 is intended to be in contact with the skin;
3. as shown in fig. 3, the present invention includes, in order from the bottom to the top in the drawing: a drug layer 60, a substrate layer 10, a negative electrode layer 30, a photo-functional layer 40, a positive electrode layer 20, and an encapsulation layer 50; the device emits light (in the direction of the arrow in the figure) from the substrate layer 10 side, and the drug layer 60 is intended to be in contact with the skin;
4. as shown in fig. 4, the present invention includes, in order from the bottom to the top in the drawing: a substrate layer 10, a negative electrode layer 30, a light function layer 40, a positive electrode layer 20, a packaging layer 50, and a drug layer 60; the device emits light (in the direction of the arrows in the figure) from the encapsulation layer 50 side, and the drug layer 60 is intended to be in contact with the skin.
Wherein the encapsulation layer 50 is electrically conductive, which can be optionally implemented by any one of the following:
in the method a, the material of the packaging layer 50 is a conductive material; the packaging layer is used as the first lead-in electrode; and an insulating layer is arranged on one side of the packaging layer close to the optical function layer. The encapsulation layer 50 may be, for example, a metal sheet, such as a metal foil, which is attached to the insulating layer formed on the side thereof close to the optical function layer 40; the encapsulation layer 50 can be prepared on the insulating layer on the side thereof close to the optical function layer 40 by, for example, evaporation, spin coating, sputtering, screen printing, inkjet printing, or the like; the material of the sealing layer 50 may be, for example, a metal such as titanium, aluminum, copper, or iron, or a metal alloy or a nano metal, which functions as a barrier to water and oxygen and as a first introduction electrode, and forms an electric field with the skin after a voltage is applied, so that the drug is transferred into the body.
When the light medical device emits light from one side of the packaging layer 50, the outer structural layer (i.e. the packaging layer 50) is made of transparent material which can transmit light. The material may be, for example, PEDOT, PSS [ poly (3, 4-ethylenedioxythiophene): polystyrene sulfonate salt) is mixed into an organic material to form a conductive material.
In some embodiments of the present application, as shown in fig. 13, the insulating layer on the side of the encapsulation layer 50 adjacent to the optical function layer includes a second water-resistant layer 120 and a barrier glue layer 130;
the second water resistant layer 120 is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the second water resistant layer 120 is prepared by at least one of ALD, PECVD, IJP, screen printing, or sputtering. The second water-blocking layer 120 is used for blocking water and oxygen, so that the packaging and water-oxygen resistance of the optical medical device can be improved, and the service life of the optical medical device can be prolonged.
The barrier rubber layer 130 is composed of at least one of polyolefin and rubber; the barrier adhesive layer is doped with a water absorbing material, and the water absorbing material can be calcium oxide or barium oxide and the like.
In some embodiments of the present application, as shown in FIG. 12, the insulating layer on the side of the encapsulation layer 50 adjacent to the optically functional layer includes only the second water resistant layer 120. In this case, if the encapsulation layer 50 is a full-surface metal layer, it may not only function as the first introduction electrode or the second introduction electrode, but also further function as a barrier to water and oxygen.
In the method b, the packaging layer 50 is made of an insulating material, and a conductive layer is formed on the surface of the packaging layer; the encapsulation layer 50 is, for example, a barrier film, and the conductive layer may be, for example, a metal sheet, and is formed on the barrier film in an attached manner; the conductive layer can be prepared on the barrier film by means of evaporation, spin coating, sputtering, screen printing, inkjet printing, and the like, for example; the conductive layer serves as the first lead-in electrode; the side of the conductive layer close to the optical function layer is provided with an insulating layer, and in this case, the insulating layer may be, for example, the barrier film itself, or may further include a second water-resistant layer 120, or further includes the second water-resistant layer 120 and a barrier adhesive layer 130.
The power supply design of the optical medical device can be selected by adopting any one of the following modes:
the first method is as follows: the photomedical device independently supplies power to the optical function layer and the electric field, as shown in fig. 1 to 4, the control circuit of the photomedical device includes a first power supply circuit 91 and a second power supply circuit 92; two power supply terminals of the first power supply circuit 91 are connected to the positive electrode layer and the negative electrode layer, respectively; the two power supply terminals of the second power supply circuit 92 are electrically connected to the first and second lead-in electrodes 70, respectively.
In this embodiment, the photomedical device is an OLED, the OLED is provided with fpc, fpc leading out power supply lines of the positive electrode layer and the negative electrode layer, and the power supply lines are used for being connected with a control module of the OLED, and the control module applies power supply signals to the positive electrode layer and the negative electrode layer so as to adjust and control the on/off and the light-emitting brightness of the OLED;
the first power supply circuit supplies power to the positive electrode layer and the negative electrode layer through the FPC to light the OLED so that the OLED emits light for treatment; the first power supply circuit is an integrated circuit disposed within the control module.
In this embodiment, a second power supply circuit is additionally disposed on the control module of the photomedical device, the second power supply circuit is used for supplying power to the first lead-in electrode and the second lead-in electrode, and the second lead-in electrode 70 can be attached to the skin of the human body; for example, a circuit connected with the conductive part of the packaging layer is added on the FPC, and after the second power supply circuit is communicated with a power supply, the packaging layer and the skin form an electric field, so that the medicine migrates into the body; the medicine is absorbed by the skin more, so that the curative effect of the photomedical treatment and the medicine is more obvious. The second power supply circuit may be a separately provided circuit or may be a circuit integrated within the control module of the photomedical device.
The second method comprises the following steps: in the first embodiment, the photomedical device alternately supplies power to the photofunctional layer and the electric field, that is, the first power supply circuit 91 and the second power supply circuit 92 alternately supply power. When both the first power supply circuit 91 and the second power supply circuit 92 are powered by an integrated circuit integrated in the control chip of the photomedical device, then the switching of the first power supply circuit 91 and the second power supply circuit 92 can be realized by setting the control program of the integrated circuit.
This approach is preferably applicable to the case shown in fig. 1 and 3, in which case the electric field for drug introduction crosses the various device layers of the OLED, and the operating circuit of the OLED and the electric field circuit for drug introduction operate separately, so that the influence of the drug introduction electric field on the operation of the OLED can be avoided.
The third method comprises the following steps: as shown in fig. 5 and 6, the first lead-in electrode is electrically connected to the positive electrode layer 20; that is, the conductive portion of the encapsulation layer is connected to the positive electrode layer 20; the photomedical device alternately supplies power to the optical function layer and the electric field through the control circuit; the switching of the control circuit can be realized by setting a control program of the integrated circuit, and the control circuit is the integrated circuit in the control chip. The control chip can be a single chip microcomputer or an ARM controller.
The power supply circuit of the photomedical device includes a first power supply terminal 93 and a second power supply terminal 94 having opposite electric polarities, the first power supply terminal 93 being electrically connected to the positive electrode layer 20, and the second power supply terminal 94 being alternately electrically connected to the second introduction electrode 70 and the negative electrode layer 30. In this embodiment, the control circuit 95 switches the connection state of the second power supply terminal 94, and when the second power supply terminal 94 is connected to the second introduction electrode 70, a drug introduction electric field is formed between the positive electrode layer connected to the encapsulation layer and the human tissue 80; when the second power supply terminal 94 is electrically connected to the negative electrode layer 30, the light functional layer of the photo-medical device operates to emit light for photo-medical treatment. The mode not only realizes the power supply of the two functional circuits, but also realizes the switching work of the two functional circuits, and avoids mutual influence.
It should be noted that in this embodiment, when the different functional circuits operate, the power supply voltages of the power supply circuits may be different, for example, when the optical functional layer operates, the power supply current is 100mA, and when the drug is introduced into the electric field to operate, the power supply current is 10 mA; the control chip of the optical medical device can realize the adjustment of the power supply current when different power supply circuits work.
The method is as follows: as shown in fig. 7 and 8, the first lead-in electrode is electrically connected to the negative electrode layer 30; that is, the conductive portion of the encapsulation layer is connected to the negative electrode layer 30; the photomedical device alternately supplies power to the optical function layer and the electric field through the control circuit; the power supply circuit of the photomedical device includes a first power supply terminal 93 and a second power supply terminal 94 having opposite electric polarities, the first power supply terminal 93 being electrically connected to the negative electrode layer 30, and the second power supply terminal 94 being alternately electrically connected to the second lead-in electrode 70 and the positive electrode layer 20.
In this embodiment, the control circuit 95 switches the connection state of the second power supply terminal 94, and when the second power supply terminal 94 is connected to the second introduction electrode 70, a drug introduction electric field is formed between the negative electrode layer connected to the encapsulation layer and the human tissue 80; when the second power supply terminal 94 is electrically connected to the positive electrode layer 20, the light functional layer of the photo-medical device operates, and light is emitted to perform photo-medical treatment. The mode not only realizes the power supply of the two functional circuits, but also realizes the switching work of the two functional circuits, and avoids mutual influence.
When the circuits with different functions work, the directions of the power supply currents of the power supply circuit can be different, and the positive electrode layer is ensured to be always connected with the positive electrode of the power supply through switching of the power supply voltage, so that the negative electrode layer is always connected with the negative electrode of the power supply; when different functional circuits work, the supply current of the power supply circuit can be different.
In certain embodiments of the present application, wherein the drug layer is an ionizable drug, the drug layer is capable of moving with an electric field; for example, the drug layer is gel doped with drugs, the drugs are directly dissociated under the electric field, and then drug ions move along the electric field. For example, potassium chloride (potassium ion is cation) can be introduced to improve the excitability of nerve and muscle, and can be used for treating peripheral neuritis and nerve paralysis. For another example, radix Aconiti Kusnezoffii (containing alkaloid as main ingredient and cation) can be introduced for treating arthralgia and neuralgia caused by hyperosteogeny. The most common method for treating hyperosteogeny is to use edible vinegar (the main component of the edible vinegar is acetic acid, containing anions) as the introduced drug. Acetic acid ions enter the body through the skin under the action of an electric field and interact with calcium ions on bones to reduce the deposition of calcium salts, diminish inflammation and relieve pain, and the photomedical treatment can also diminish inflammation and relieve pain, so that the aim of treating hyperosteogeny is fulfilled under the synergistic action.
The power supply circuit supplies power to the electric field according to the characteristics of ions in the medicine layer, if the ions in the medicine layer are positive ions, the second lead-in electrode for adhering to the skin of the human body is an anode and is connected with the anode of the power supply, and the first lead-in electrode opposite to the second lead-in electrode is a cathode and is connected with the cathode of the power supply. If the electric ions in the medicine layer are anions, the second lead-in electrode for adhering to the skin of a human body is a cathode and is connected with the cathode of the power supply, and the first lead-in electrode opposite to the second lead-in electrode is an anode and is connected with the anode of the power supply.
In certain embodiments of the present application, as shown in fig. 10, when the light-emitting direction of the photomedical device is on one side of the encapsulating layer, the side of the encapsulating layer 50 that is relatively close to the drug layer is provided with a barrier layer 100; as shown in fig. 11, when the light emitting direction of the photomedical device is located on one side of the substrate layer 10, the side of the substrate layer 10 relatively close to the drug layer 60 is provided with an isolating layer 100; the isolation layer 100 is made of at least one of indium tin oxide paint or aerogel; the spacer layer 100 is preferably doped with scattering particles. The isolation layer 100 is used to isolate and improve the light emission of the OLED, and is made of ito (indium tin oxide) paint, aerogel, etc., and is mixed with scattering particles, such as titanium oxide. At the same time, the isolation layer 100 may act as an insulating layer between the isolating outer structural layer and the drug layer.
In some embodiments of the present application, as shown in fig. 11, a first water-blocking layer 110 is disposed on a side of the substrate layer 10 relatively close to the optically functional layer 40; the first water resistant layer 110 is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the water-resistant layer is prepared by at least one method of ALD, PECVD, IJP, screen printing or sputtering. The first water-blocking layer 110 is used for blocking water and oxygen, and can improve the packaging and water-oxygen resistance of the photomedical device and prolong the service life.
In certain embodiments of the present application, as shown in FIGS. 14-15, the drug layer is spaced partially over the light exit side of the photomedical device; the drug layer 60 is in a grid or graphical design, so that the light emitted from the photomedical device can be more emitted from the space between the drug layers, and the photomedical effect is further improved.
In some embodiments of the present application, the material of the positive electrode layer includes, for example, ITO and/or IZO, and the photo-functional layer includes a hole injection layer, a hole transport layer, an electron blocking layer, a light emitting layer, a hole blocking layer, and an electron blocking layer, which are sequentially stacked; the material of the negative electrode layer includes Ag and/or Al.
Example two
This example differs from example 1 by the following differences: the first lead-in electrode is arranged on a substrate layer, specifically, a conductive structure is arranged on the substrate layer 10, and the structure of the substrate layer 10 can be selectively realized by the following steps:
the first method is as follows: the substrate layer 10 is made of a conductive material; for example, it is a metal foil, and an insulating layer is arranged on one side of the metal foil close to the optical function layer, and the insulating layer is a first water-resistant layer for example; the substrate layer serves as the first lead-in electrode.
When the light medical device emits light from one side of the substrate layer, the outer structure layer (namely, the substrate layer) is made of transparent material which can transmit light. The material may be, for example, PEDOT, PSS (poly 3, 4-ethylenedioxythiophene): polystyrene sulfonate) is mixed into an organic material to form a conductive material.
The second method comprises the following steps: the substrate layer 10 includes a substrate and a metal layer, the substrate is organic polymer such as PET, PEN, PI, etc., the metal layer is prepared by evaporation, spin coating, sputtering, screen printing, inkjet printing, etc., and the material of the metal layer is metal such as titanium, aluminum, copper, iron, etc., or metal alloy or nano metal.
When the photomedical device emits light from the substrate layer side, the light transmittance of the metal layer is greater than 50%, which functions as a barrier to water and oxygen and as a drug introduction electrode, and the metal layer in the substrate layer 10 is located on the side of the substrate away from the photofunctional layer.
And the substrate layer 10 comprises a substrate, a metal layer and an insulating layer, wherein the substrate is organic polymers such as PET, PEN and PI, the metal layer is prepared by evaporation, spin coating, sputtering, screen printing, ink-jet printing and the like, and the metal layer is made of metals such as titanium, aluminum, copper and iron, or metal alloys or nano metals.
When the photomedical device emits light from the substrate layer side, the metal layer has a light transmittance of greater than 50% and functions as a barrier to water and oxygen and as a drug introduction electrode, the metal layer is located between the substrate and the insulating layer, and the insulating layer is located on the side close to the photofunctional layer 40, which may be the first water-resistant layer in the first embodiment.
In this example, an induced electric field for achieving the drug layer is formed between the substrate layer and the human body, or between the conductive layer attached to the substrate layer and the human body, as compared to example 1.
As shown in fig. 16 and 17, this embodiment is applicable not only to an OLED device that emits light from the substrate layer 10 side, but also to an OLED device that emits light from the encapsulation layer 50 side.
As shown in fig. 16 and 17, in this embodiment, two functional circuits (an electric field circuit for introducing a drug, and a circuit for operating an OLED device) can be respectively powered by the second power supply circuit 92 and the first power supply circuit 91, so that two processes of phototherapy and drug introduction can be simultaneously implemented, and the therapeutic effect is better.
As shown in fig. 18 to fig. 21, as in embodiment 1, the two functional circuits are shared in this embodiment, and the control circuit is used to implement the alternate operation of the two functional circuits, so as to avoid the mutual influence caused by the introduction of the drug into the electric field passing through the OLED device, and simplify the circuit structure.
The above description is only a preferred embodiment of the application and is illustrative of the principles of the technology employed. It will be appreciated by a person skilled in the art that the scope of the invention as referred to in the present application is not limited to the embodiments with a specific combination of the above-mentioned features, but also covers other embodiments with any combination of the above-mentioned features or their equivalents without departing from the inventive concept. For example, the above features may be replaced with (but not limited to) features having similar functions disclosed in the present application.

Claims (10)

1. The photomedical device is characterized by comprising a substrate layer, a positive electrode layer or a negative electrode layer, a photofunctional layer, a negative electrode layer or a positive electrode layer and a packaging layer which are arranged in sequence; the positive electrode layer and the negative electrode layer exist at the same time; the light-emitting side of the photomedical device is provided with a medicine layer; the photomedical device is also provided with an electric field forming structure that includes:
the first lead-in electrode is arranged on an outer structure layer, and the outer structure layer is a substrate layer or a packaging layer;
the second lead-in electrode has opposite polarity to the first lead-in electrode and is used for being attached to the photomedical tissue;
the photomedical device forms an electric field for drug introduction by powering the first and second introduction electrodes.
2. The photomedical device of claim 1, wherein the outer structural layer is made of a conductive material; the outer structural layer forms the first lead-in electrode; an insulating layer is arranged on one side, close to the optical function layer, of the outer structure layer; when the optical medical device emits light from one side of the outer structure layer, the outer structure layer is made of transparent material which can transmit light.
3. The photomedical device of claim 1, wherein the outer structural layer is made of an insulating material and has a conductive layer formed on a surface thereof; the conductive layer forms the first lead-in electrode; one side of the conductive layer, which is close to the optical function layer, is provided with an insulating material; when the light medical device emits light from one side of the outer structure layer, the conducting layer is made of transparent materials which can transmit light or light holes are formed in the conducting layer.
4. The photomedical device of claim 1, wherein the photomedical device independently powers the optically functional layer and the electric field, or wherein the photomedical device alternately powers the optically functional layer and the electric field.
5. The photomedical device of claim 1, wherein the outer structural layer is electrically connected to the positive or negative electrode layer, the photomedical device alternately powering the photofunctional layer and the electric field via a control circuit.
6. The photomedical device of any one of claims 1-5, wherein an isolation layer is disposed on a side of the outer structural layer adjacent to the pharmaceutical layer, the isolation layer being made of at least one of indium tin oxide paint or aerogel; the spacer layer is preferably doped with scattering particles.
7. The photomedical device of any one of claims 1-5, wherein the substrate layer is provided with a first water resistant layer on a side thereof adjacent to the light functional layer; the first water resisting layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the first waterproof layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering.
8. The photomedical device of any one of claims 1-5, wherein a second water resistant layer is disposed between the encapsulating layer and the photofunctional layer, the second water resistant layer being comprised of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy or polyolefin; the second water-resistant layer is prepared by at least one method of ALD, PECVD, IJP, screen printing or sputtering.
9. The photomedical device of any one of claims 1-5, wherein a layer of barrier adhesive is disposed between the encapsulating layer and the photofunctional layer, the layer of barrier adhesive being comprised of at least one of a polyolefin and a rubber; and the water absorption material is doped in the blocking adhesive layer.
10. The photomedical device of any one of claims 1-5, wherein the exposed portion of the outer structural layer is wrapped with an insulating material; the medicine layer is gel doped with medicine.
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