CN114868762A - Composite intermediate-effect disinfectant and preparation method thereof - Google Patents
Composite intermediate-effect disinfectant and preparation method thereof Download PDFInfo
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- CN114868762A CN114868762A CN202210443358.6A CN202210443358A CN114868762A CN 114868762 A CN114868762 A CN 114868762A CN 202210443358 A CN202210443358 A CN 202210443358A CN 114868762 A CN114868762 A CN 114868762A
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 126
- 239000002131 composite material Substances 0.000 title claims abstract description 116
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 86
- 239000002994 raw material Substances 0.000 claims abstract description 34
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims abstract description 22
- 239000005708 Sodium hypochlorite Substances 0.000 claims abstract description 19
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract description 19
- 230000000694 effects Effects 0.000 claims abstract description 18
- 239000005725 8-Hydroxyquinoline Substances 0.000 claims abstract description 11
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 11
- 229960003540 oxyquinoline Drugs 0.000 claims abstract description 11
- -1 polyoxyethylene Polymers 0.000 claims abstract description 11
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 24
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 24
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 24
- 238000002156 mixing Methods 0.000 claims description 20
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 16
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 239000011780 sodium chloride Substances 0.000 claims description 12
- 229910052582 BN Inorganic materials 0.000 claims description 11
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 claims description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 6
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims description 6
- YWFWDNVOPHGWMX-UHFFFAOYSA-N n,n-dimethyldodecan-1-amine Chemical compound CCCCCCCCCCCCN(C)C YWFWDNVOPHGWMX-UHFFFAOYSA-N 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 claims description 4
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 66
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract description 43
- 239000000460 chlorine Substances 0.000 abstract description 43
- 229910052801 chlorine Inorganic materials 0.000 abstract description 43
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 16
- 241000588724 Escherichia coli Species 0.000 abstract description 13
- 244000063299 Bacillus subtilis Species 0.000 abstract description 12
- 235000014469 Bacillus subtilis Nutrition 0.000 abstract description 12
- 241000222122 Candida albicans Species 0.000 abstract description 12
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract description 12
- 229940095731 candida albicans Drugs 0.000 abstract description 12
- 238000010790 dilution Methods 0.000 abstract description 11
- 239000012895 dilution Substances 0.000 abstract description 11
- 150000001875 compounds Chemical class 0.000 abstract description 10
- 238000000034 method Methods 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 10
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 238000000354 decomposition reaction Methods 0.000 description 6
- 241000700605 Viruses Species 0.000 description 5
- 239000003899 bactericide agent Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000003513 alkali Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000011056 performance test Methods 0.000 description 3
- 210000004215 spore Anatomy 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The application relates to the technical field of disinfectant, and particularly discloses a composite intermediate-effect disinfectant and a preparation method thereof, wherein the composite intermediate-effect disinfectant comprises the following raw materials in parts by weight: 5-10 parts of sodium hypochlorite, 1-3 parts of potassium bromide, 5-10 parts of 8-hydroxyquinoline, 0.5-1 part of alkylphenol polyoxyethylene and 80-100 parts of deionized water. The effective chlorine content, the reduction rate of the effective chlorine after 24-hour dilution, the sterilization rate of escherichia coli, the sterilization rate of staphylococcus aureus, the sterilization rate of pseudomonas aeruginosa, the sterilization rate of candida albicans and the sterilization rate of bacillus subtilis var niger spores are respectively 3.48%, 94.5%, 99.999% and 99.83%, the reduction rate of the effective chlorine is 4.6% after the compound moderate-effect disinfectant is placed at 54 ℃ for 14 days, and the stability of the compound moderate-effect disinfectant is improved under the condition of better sterilization effect.
Description
Technical Field
The application relates to the field of disinfectant, in particular to a composite intermediate-effect disinfectant and a preparation method thereof.
Background
Currently, a large amount of disinfection solution is used for daily disinfection and sterilization to protect the health of the human. The disinfectant is mainly divided into three types of high efficiency, medium efficiency and low efficiency, wherein the high efficiency disinfectant has stronger oxidability and stronger chemical toxicity to organisms, is commonly used for disinfecting some equipment or places, can kill all bacteria propagules, viruses, fungi, spores thereof and the like, has certain killing effect on bacterial spores, and meets the preparation with high-level disinfection requirement; the low-efficiency disinfectant is a preparation which can only kill bacterial propagules and lipophilic viruses and meet the requirements of the disinfectant; the intermediate disinfectant is a preparation which can only kill microorganisms such as mycobacteria, fungi, viruses, bacterial propagules and the like to meet the disinfection requirement, and is divided into chlorine-containing disinfectant, iodine-containing disinfectant, alcohol disinfectant and phenol disinfectant.
In the related technology, the main component of the chlorine-containing disinfectant in the intermediate-effect disinfectant is sodium hypochlorite, which has poor stability, is easy to decompose, is volatile in air, influences the disinfection effect, and causes the problems of flammability, explosiveness and the like.
Disclosure of Invention
In order to improve the stability of the intermediate-effect disinfectant, the application provides a composite intermediate-effect disinfectant and a preparation method thereof.
In a first aspect, the present application provides a composite intermediate-effect disinfection solution, which adopts the following technical scheme:
a composite intermediate-effect disinfectant comprises the following raw materials in parts by weight: 5-10 parts of sodium hypochlorite, 1-3 parts of potassium bromide, 5-10 parts of 8-hydroxyquinoline, 0.5-1 part of alkylphenol polyoxyethylene, 0.3-0.7 part of sodium carbonate, 0.04-0.06 part of dodecyl dimethyl ammonium oxide, 0.1-0.15 part of didecyl dimethyl ammonium chloride and 80-100 parts of deionized water.
The composite intermediate effect disinfectant comprises, by weight, 5-10 parts of sodium hypochlorite, 1-3 parts of potassium bromide, 5-10 parts of 8-hydroxyquinoline, 0.5-1 part of alkylphenol polyoxyethylene, 0.3-0.7 part of sodium carbonate, 0.04-0.06 part of dodecyl dimethyl ammonium oxide, 0.1-0.15 part of didecyl dimethyl ammonium chloride and 80-100 parts of deionized water, and has a predictable performance effect, and when 8 parts of sodium hypochlorite, 2 parts of potassium bromide, 8 parts of 8-hydroxyquinoline, 0.8 part of alkylphenol polyoxyethylene, 0.5 part of sodium carbonate, 0.05 part of dodecyl dimethyl ammonium oxide, 0.13 part of didecyl dimethyl ammonium chloride and 90 parts of deionized water, the optimal effect is achieved.
By adopting the technical scheme, the sodium hypochlorite is added as the main component of the disinfectant, and the hypochlorous acid in the sodium hypochlorite is the active component and mainly plays a role in disinfection.
The potassium bromide and the 8-hydroxyquinoline are added as the stabilizing agents, so that the decomposition of sodium hypochlorite in the composite intermediate disinfectant can be slowed down, and possible organic matters on the surface of the virus can be removed, so that the virus can be better contacted with the composite intermediate disinfectant, and the stability of the composite intermediate disinfectant is improved.
The alkylphenol polyoxyethylene is added as a surfactant, has the characteristics of stable property and acid and alkali resistance, and improves the stability of the composite intermediate-effect disinfectant.
Preferably, the method comprises the following steps: a composite intermediate-effect disinfectant comprises the following raw materials in parts by weight: 7-9 parts of sodium hypochlorite, 1.5-2.5 parts of potassium bromide, 7-9 parts of 8-hydroxyquinoline, 0.7-0.9 part of alkylphenol polyoxyethylene, 0.04-0.06 part of sodium carbonate, 0.045-0.055 part of dodecyl dimethyl ammonium oxide, 0.11-0.14 part of didecyl dimethyl ammonium chloride and 85-95 parts of deionized water.
Preferably, the method comprises the following steps: the alkylphenol polyoxyethylene ether is obtained by pre-modifying with sulfamic acid.
By adopting the technical scheme, the alkylphenol polyoxyethylene ether is modified by the sulfamic acid, so that the dispersibility and the solubilization of the alkylphenol polyoxyethylene ether in the composite intermediate disinfectant system are improved on one hand, and the alkylphenol polyoxyethylene ether has two hydrophilic groups with different properties on the other hand, so that the alkylphenol polyoxyethylene ether has the characteristics of non-ionic and anionic surfactants, has higher alkali resistance, high temperature resistance and excellent decomposition resistance, and further improves the stability of the composite intermediate disinfectant.
Preferably, the method comprises the following steps: the specific operation steps of modifying the alkylphenol polyoxyethylene ether are as follows: mixing alkylphenol polyoxyethylene ether and amino sulfuric acid according to the volume ratio of 1 (1-1.2), uniformly stirring, then adding formamide according to the volume ratio of 1 (1-0.5) to the alkylphenol polyoxyethylene ether and the formamide, uniformly stirring, and reacting at the temperature of 130-135 ℃ for 1-2h to obtain the modified alkylphenol polyoxyethylene ether.
By adopting the scheme, the alkylphenol polyoxyethylene ether is mixed with the formamide, the catalyst formamide is added for reaction, and the alkylphenol polyoxyethylene ether is modified, so that the modified alkylphenol polyoxyethylene ether has excellent surface activity, solubilization and moderate emulsibility, the effect of the alkylphenol polyoxyethylene ether in the composite intermediate-effect disinfectant is further improved, and the stability of the composite intermediate-effect disinfectant is further improved.
Preferably, the method comprises the following steps: the composite intermediate effect disinfectant also comprises 1-3 parts by weight of boron nitride and 0.5-0.7 part by weight of sodium chloride.
By adopting the technical scheme, the boron nitride has a stabilizing effect on the composite intermediate-effect disinfectant, the sodium chloride can promote the decomposition of the sodium hypochlorite to be carried out in the opposite direction, and the boron nitride and the sodium chloride are mixed to be used as a stabilizer, so that the stability of the composite intermediate-effect disinfectant can be improved, and the storage time of the composite intermediate-effect disinfectant can be prolonged.
Preferably, the method comprises the following steps: the composite intermediate-effect disinfectant also comprises 3-5 parts by weight of polyvinylpyrrolidone.
By adopting the technical scheme, on one hand, the polyvinylpyrrolidone is added as a corrosion inhibitor, so that the corrosivity of sodium hypochlorite can be effectively reduced, the corrosion degree of the surface of a sterilized object is reduced, and the application range of the composite intermediate-effect disinfectant is expanded; on the other hand, the polyvinylpyrrolidone is added as a dispersing agent, so that the dispersion uniformity of each raw material of the composite intermediate-effect disinfectant is improved, and the effect of each raw material in the composite intermediate-effect disinfectant is further improved.
Preferably, the method comprises the following steps: the pH value of the composite intermediate-effect disinfectant is 7-9.
By adopting the technical scheme, the pH value of the composite intermediate-effect disinfectant is controlled to be 7-9, so that the quick decomposition of the effective chlorine of the disinfectant is avoided, the activity is prevented from meeting the requirement, and the stability of the composite intermediate-effect disinfectant is further improved.
In a second aspect, the present application provides a method for preparing any one of the above composite intermediate-effect disinfection solutions, which is specifically realized by the following technical scheme:
a preparation method of a composite intermediate-effect disinfectant comprises the following operation steps:
filtering sodium hypochlorite to remove precipitate for later use;
and mixing the raw materials of the composite intermediate-effect disinfectant, uniformly stirring, and adjusting the pH value to obtain the composite intermediate-effect disinfectant.
In summary, the present application includes at least one of the following beneficial technical effects:
(1) by controlling the types and the mixing amount of the raw materials of the composite intermediate-effect disinfectant, the effective chlorine content, the reduction rate of the effective chlorine after dilution for 24 hours, the sterilization rate of escherichia coli, the sterilization rate of staphylococcus aureus, the sterilization rate of pseudomonas aeruginosa, the sterilization rate of candida albicans and the sterilization rate of bacillus subtilis var niger are respectively 2.65%, 89.9%, 97.79%, 98.89%, 96.78%, 97.53% and 96.75%, the reduction rate of the effective chlorine is 5.9% after the composite intermediate-effect disinfectant is placed at 54 ℃ for 14 days, and the stability of the composite intermediate-effect disinfectant is improved under the condition of better sterilization effect.
(2) By modifying alkylphenol ethoxylates in the composite middle-effect disinfectant, the effective chlorine content, the reduction rate of effective chlorine after dilution for 24 hours, the sterilization rate of escherichia coli, the sterilization rate of staphylococcus aureus, the sterilization rate of pseudomonas aeruginosa, the sterilization rate of candida albicans and the sterilization rate of bacillus subtilis var niger are respectively 2.78%, 90.5%, 98.15%, 99.15%, 97.18%, 97.62% and 97.32%, and the reduction rate of effective chlorine is 5.7% after the composite middle-effect disinfectant is placed at 54 ℃ for 14 days, so that the stability of the composite middle-effect disinfectant is further improved.
(3) According to the application, the boron nitride and the sodium chloride are added into the raw materials of the composite middle-effect disinfectant, and the mixing amount of the boron nitride and the sodium chloride is adjusted, so that the effective chlorine content, the dilution rate of 24h effective chlorine, the escherichia coli sterilization rate, the staphylococcus aureus sterilization rate, the pseudomonas aeruginosa sterilization rate, the candida albicans sterilization rate and the bacillus subtilis var niger sterilization rate of 3.28%, 92.3%, 98.91%, 99.56%, 98.91%, 98.56% and 98.54% respectively, and the effective chlorine reduction rate of 14d after the composite middle-effect disinfectant is placed at 54 ℃ is 5.0%, and the stability of the composite middle-effect disinfectant is improved.
(4) According to the application, on the basis of adding boron nitride and sodium chloride into the raw materials of the composite middle-effect disinfectant, polyvinylpyrrolidone is added, so that the effective chlorine content, the dilution 24-hour effective chlorine reduction rate, the escherichia coli sterilization rate, the staphylococcus aureus sterilization rate, the pseudomonas aeruginosa sterilization rate, the candida albicans sterilization rate and the bacillus subtilis black variant spore sterilization rate of the composite middle-effect disinfectant are respectively 3.48%, 94.5%, 99.999% and 99.83%, and the 14d effective chlorine reduction rate is 4.6% when the composite middle-effect disinfectant is placed at 54 ℃, and the stability of the composite middle-effect disinfectant is further improved.
Detailed Description
The present application will be described in further detail with reference to specific examples.
The following raw materials are all commercially available products, and are all sufficient for disclosure of the raw materials in the present application, and should not be construed as limiting the source of the raw materials. The method specifically comprises the following steps: sodium hypochlorite with effective substance content of 90%; alkylphenol ethoxylates, type op-10; polyvinylpyrrolidone, type k 30.
Example 1
The composite intermediate-effect disinfectant is prepared by the following operation steps:
filtering sodium hypochlorite according to the mixing amount shown in the table 1, and removing precipitates for later use;
mixing sodium hypochlorite, potassium bromide, 8-hydroxyquinoline, alkylphenol ethoxylate and deionized water, stirring uniformly, and adjusting the pH value to 8 to obtain the composite intermediate-effect disinfectant.
Examples 2 to 5
The composite intermediate disinfectant of examples 2 to 5 has the same preparation method and the same types of raw materials as those of example 1, except that the mixing amounts of the raw materials are different, and the details are shown in table 1.
TABLE 1 amount of each raw material (unit: kg) of the composite intermediate disinfectant of examples 1-5
Example 6
The compound middle-effect disinfectant in the embodiment 6 is completely the same as the raw material mixing amount and the preparation method in the embodiment 3, and is different from the compound middle-effect disinfectant in that alkylphenol polyoxyethylene ether is obtained by pre-modification treatment of sulfamic acid, and the specific operation steps of the modification of the alkylphenol polyoxyethylene ether are as follows: mixing alkylphenol polyoxyethylene ether and amino sulfuric acid according to the volume ratio of 1:1.1, uniformly stirring, then adding formamide according to the volume ratio of 1:0.8 of alkylphenol polyoxyethylene ether and formamide, uniformly stirring, and reacting at 130 ℃ for 1h to obtain the modified alkylphenol polyoxyethylene ether. The other raw material types and the amounts thereof were the same as in example 3.
Examples 7 to 11
The preparation methods of the composite intermediate disinfectant of examples 7 to 11 are completely the same as those of example 6, except that boron nitride and sodium chloride are further added to the raw materials of the composite intermediate disinfectant, and the specific mixing amounts are shown in table 2.
TABLE 2 amount of each raw material (unit: kg) of the composite intermediate disinfectant of examples 7 to 11
Examples 12 to 14
The preparation methods of the compound intermediate disinfectant of examples 12 to 14 are completely the same as those of example 6, except that polyvinylpyrrolidone is further added to the raw material of the compound intermediate disinfectant, and the specific mixing amount is shown in table 3.
TABLE 3 amount of each raw material (unit: kg) of the composite intermediate disinfectant of examples 12 to 14
Example 15
The preparation method of the composite intermediate-effect disinfectant in the embodiment 15 is completely the same as that of the embodiment 13, except that 2kg of boron nitride and 0.6kg of sodium chloride are also added into the raw materials of the composite intermediate-effect disinfectant, and the types and the mixing amounts of the other raw materials are completely the same.
Comparative example 1
The composite intermediate-effect disinfection solution of the comparative example 1 is completely the same as the preparation method of the example 1, and the difference is that: potassium bromide is not added into the raw materials of the composite intermediate-effect disinfectant, and the other raw materials and the mixing amount are the same as those in the example 1.
Comparative example 2
The composite intermediate-effect disinfectant of the comparative example 2 is completely the same as the preparation method of the example 1, except that: the raw materials of the composite intermediate effect disinfectant are not added with 8-hydroxyquinoline, and the other raw materials and the mixing amount are the same as those in the embodiment 1.
Comparative example 3
The composite intermediate-effect disinfection solution of the comparative example 3 is completely the same as the preparation method of the example 1, and the difference is that: the raw materials of the composite intermediate-effect disinfectant are not added with alkylphenol polyoxyethylene, and the other raw materials and the mixing amount are the same as those in the embodiment 1.
Comparative example 4
The composite intermediate-effect disinfectant of the comparative example 4 is completely the same as the preparation method of the example 1, except that: the pH value of the composite intermediate effect disinfectant is adjusted to 10, and the other raw materials and the mixing amount are the same as those in the example 1.
Performance detection
The composite intermediate effect disinfectant of the examples 1 to 15 and the comparative examples 1 to 4 were respectively tested by the following test methods and standards, and the test results are specifically shown in tables 4 and 5.
Effective chlorine content: the assay was carried out according to the protocol defined in Disinfection Specification (2002 edition) 2.2.1.2.1, as detailed in Table 4.
14d of decrease rate of available chlorine when placed at 54 ℃: placing the compound intermediate-effect disinfectant sample at 54 ℃ for 14 days, and calculating the reduction rate of the effective chlorine of the compound intermediate-effect disinfectant sample placed at 54 ℃ for 14 days, wherein the details are shown in Table 4.
Diluting for 24h, and reducing rate of available chlorine: the compound intermediate disinfectant sample is diluted to have the effective chlorine content of 0.5%, and the effective chlorine reduction rate of the compound intermediate disinfectant sample diluted for 24 hours is detected, and the details are shown in table 4.
The sterilization rate of escherichia coli is as follows: the sterilization rate of the composite intermediate-effect bactericide on escherichia coli is performed according to the method specified in disinfection technical Specification (2002 edition) 2.1.1.7.5, and is specifically shown in table 5.
Staphylococcus aureus bactericidal rate: the sterilizing rate of the composite intermediate-effect bactericide on staphylococcus aureus is carried out according to the method specified in the technical specification for disinfection (2002 edition) 2.1.1.7.5, and is specifically shown in table 5.
The pseudomonas aeruginosa bactericidal rate: the sterilizing rate of the composite intermediate-effect bactericide on staphylococcus aureus is carried out according to the method specified in the technical specification for disinfection (2002 edition) 2.1.1.7.5, and is specifically shown in table 5.
Candida albicans bactericidal rate: the sterilizing rate of the composite intermediate-effect bactericide on staphylococcus aureus is carried out according to the method specified in the technical specification for disinfection (2002 edition) 2.1.1.7.5, and is specifically shown in table 5.
The sterilization rate of the black variant spores of the bacillus subtilis is as follows: the sterilizing rate of the composite intermediate-effect bactericide on staphylococcus aureus is carried out according to the method specified in the technical specification for disinfection (2002 edition) 2.1.1.7.5, and is specifically shown in table 5.
TABLE 4 Performance test results for different composite intermediate disinfectant
TABLE 5 Performance test results for different composite intermediate disinfectant
The detection results in tables 4 and 5 show that the effective chlorine content, the dilution 24-hour effective chlorine reduction rate, the escherichia coli sterilization rate, the staphylococcus aureus sterilization rate, the pseudomonas aeruginosa sterilization rate, the candida albicans sterilization rate and the bacillus subtilis var niger sterilization rate of the composite intermediate-effect disinfectant obtained by the application are respectively 3.48%, 94.5%, 99.999% and 99.83% at the highest levels, the reduction rate of the effective chlorine is 4.6% at the lowest level after the composite intermediate-effect disinfectant is placed at 54 ℃, the reduction rate is slower, the reduction rate of the diluted 24-hour effective chlorine is accelerated, the composite intermediate-effect disinfectant is shown to play a disinfection role quickly, and the stability of the composite intermediate-effect disinfectant is improved under the condition of better sterilization effect.
In examples 1 to 5, the available chlorine content, the decrease rate of available chlorine after dilution for 24 hours, the sterilization rate of escherichia coli, the sterilization rate of staphylococcus aureus, the sterilization rate of pseudomonas aeruginosa, the sterilization rate of candida albicans, and the sterilization rate of bacillus subtilis var niger were 2.65%, 89.9%, 97.79%, 98.89%, 96.78%, 97.53%, and 96.75%, respectively, which are higher than those of examples 1 to 2 and examples 4 to 5, and the decrease rate of available chlorine of the composite intermediate disinfectant of example 3 after being placed at 54 ℃ for 14 days was 5.9%, which is lower than those of examples 1 to 2 and examples 4 to 5, indicating that the mixing amount of alkylphenol polyoxyethylene ether in the composite intermediate disinfectant of example 3 is more appropriate, the stability of the composite intermediate disinfectant is improved, and the composite intermediate disinfectant may be added with alkylphenol polyoxyethylene as a surfactant, and has characteristics of stable properties, acid and alkali resistance, can improve the stability of the composite intermediate effect disinfectant.
By combining the performance test data of the composite intermediate-effect disinfectant in the embodiments 6 and 3, it can be found that the effective chlorine content, the reduction rate of the effective chlorine after dilution for 24 hours, the sterilization rate of escherichia coli, the sterilization rate of staphylococcus aureus, the sterilization rate of pseudomonas aeruginosa, the sterilization rate of candida albicans and the sterilization rate of bacillus subtilis var niger are respectively 2.78%, 90.5%, 98.15%, 99.15%, 97.18%, 97.62% and 97.32%, which are higher than those of the embodiment 3, and the reduction rate of the effective chlorine of the composite intermediate-effect disinfectant in the embodiment 6 is 5.7% after the composite intermediate-effect disinfectant is placed at 54 ℃, which is lower than that of the embodiment 3, and the improvement of the stability of the composite intermediate-effect disinfectant is shown after the alkylphenol ethoxylate in the embodiment 6 is modified, and the alkylphenol ethoxylate can be modified with sulfamic acid, so that the alkylphenol ethoxylate has the characteristics of nonionic and anionic surfactants, the alkylphenol polyoxyethylene has higher alkali resistance, high temperature resistance and excellent decomposition resistance, thereby improving the stability of the composite intermediate disinfectant.
In examples 7 to 11, the effective chlorine content, the decrease rate of the effective chlorine after dilution for 24 hours, the sterilization rate of escherichia coli, the sterilization rate of staphylococcus aureus, the sterilization rate of pseudomonas aeruginosa, the sterilization rate of candida albicans, and the sterilization rate of bacillus subtilis var niger were 3.28%, 92.3%, 98.91%, 99.56%, 98.91%, 98.56%, and 98.54%, respectively, higher than those of examples 7 to 9 and example 11, and the decrease rate of the effective chlorine of the composite intermediate disinfectant of example 10 after being placed at 54 ℃ for 14d was 5.0%, lower than those of examples 7 to 9 and example 11, which indicates that the mixing amount of boron nitride and sodium chloride in the composite intermediate disinfectant of example 10 is more appropriate, and the stability of the composite intermediate disinfectant is improved, it may be used to stabilize the composite disinfectant and the sodium chloride may promote the decomposition of sodium hypochlorite in the opposite direction.
In examples 12 to 14, the available chlorine content, the reduction rate of available chlorine after dilution for 24 hours, the sterilization rate of escherichia coli, the sterilization rate of staphylococcus aureus, the sterilization rate of pseudomonas aeruginosa, the sterilization rate of candida albicans, and the sterilization rate of bacillus subtilis var niger were 3.12%, 93.7%, 99.55%, 99.81%, 99.22%, 99.65%, and 99.46%, respectively, in the composite intermediate-effect disinfectant of example 13, which is higher than that of examples 12 and 14, and the reduction rate of available chlorine of the composite intermediate-effect disinfectant of example 13, which is 4.9% after the composite intermediate-effect disinfectant is placed at 54 ℃ for 14d, is lower than that of examples 12 and 14, indicating that the dosage of polyvinylpyrrolidone in the composite intermediate-effect disinfectant of example 13 is more appropriate, and the stability of the composite intermediate-effect disinfectant is improved.
By combining the performance detection data of the composite intermediate-effect disinfectant in the embodiments 13 and 15, it can be found that the effective chlorine content, the dilution rate of decrease of the effective chlorine for 24 hours, the escherichia coli sterilization rate, the staphylococcus aureus sterilization rate, the pseudomonas aeruginosa sterilization rate, the candida albicans sterilization rate and the bacillus subtilis var niger sterilization rate of the composite intermediate-effect disinfectant in the embodiment 15 are respectively 3.48%, 94.5%, 99.999%, and 99.83%, and the effective chlorine decrease rate of the composite intermediate-effect disinfectant in the embodiment 15 after being placed at 54 ℃ is 4.6% and is lower than that in the embodiment 13, which indicates that the stability of the composite intermediate-effect disinfectant can be further improved by adding boron nitride and sodium chloride based on the addition of polyvinylpyrrolidone into the composite intermediate-effect disinfectant.
In addition, by combining the index data of comparative examples 1-4 and example 1, the stability of the composite intermediate-effect disinfectant can be improved to different degrees by adding potassium bromide, 8-hydroxyquinoline, alkylphenol ethoxylate to the raw material of the composite intermediate-effect disinfectant and adjusting the pH value of the composite intermediate-effect disinfectant to 7-9.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. The composite intermediate-effect disinfectant is characterized by comprising the following raw materials in parts by weight: 5-10 parts of sodium hypochlorite, 1-3 parts of potassium bromide, 5-10 parts of 8-hydroxyquinoline, 0.5-1 part of alkylphenol polyoxyethylene, 0.3-0.7 part of sodium carbonate, 0.04-0.06 part of dodecyl dimethyl ammonium oxide, 0.1-0.15 part of didecyl dimethyl ammonium chloride and 80-100 parts of deionized water.
2. The composite intermediate-effect disinfection solution as claimed in claim 1, which comprises the following raw materials in parts by weight: 7-9 parts of sodium hypochlorite, 1.5-2.5 parts of potassium bromide, 7-9 parts of 8-hydroxyquinoline, 0.7-0.9 part of alkylphenol polyoxyethylene, 0.04-0.06 part of sodium carbonate, 0.045-0.055 part of dodecyl dimethyl ammonium oxide, 0.11-0.14 part of didecyl dimethyl ammonium chloride and 85-95 parts of deionized water.
3. The composite intermediate-effect disinfection solution as claimed in claim 1, wherein: the alkylphenol polyoxyethylene ether is obtained by pre-modifying with sulfamic acid.
4. The composite intermediate-effect disinfection solution as claimed in claim 3, wherein: the specific operation steps of modifying the alkylphenol polyoxyethylene ether are as follows: mixing alkylphenol polyoxyethylene ether and amino sulfuric acid according to the volume ratio of 1 (1-1.2), uniformly stirring, then adding formamide according to the volume ratio of 1 (1-0.5) to the alkylphenol polyoxyethylene ether and the formamide, uniformly stirring, and reacting at the temperature of 130-135 ℃ for 1-2h to obtain the modified alkylphenol polyoxyethylene ether.
5. The composite intermediate-effect disinfection solution as claimed in claim 1, wherein: the composite intermediate effect disinfectant also comprises 1-3 parts by weight of boron nitride and 0.5-0.7 part by weight of sodium chloride.
6. The composite intermediate-effect disinfection solution as claimed in claim 1, wherein: the composite intermediate-effect disinfectant also comprises 3-5 parts by weight of polyvinylpyrrolidone.
7. The composite intermediate-effect disinfection solution as claimed in claim 1, wherein: the pH value of the composite intermediate-effect disinfectant is 13.5-14.0.
8. The preparation method of the composite intermediate-effect disinfection solution as claimed in any one of claims 1 to 7, which is characterized by comprising the following steps:
filtering sodium hypochlorite to remove precipitate for later use;
and mixing the raw materials of the composite intermediate-effect disinfectant, uniformly stirring, and adjusting the pH value to obtain the composite intermediate-effect disinfectant.
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