CN114867453A - 各向同性浓缩物和洗涤组合物 - Google Patents
各向同性浓缩物和洗涤组合物 Download PDFInfo
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- CN114867453A CN114867453A CN202180007648.XA CN202180007648A CN114867453A CN 114867453 A CN114867453 A CN 114867453A CN 202180007648 A CN202180007648 A CN 202180007648A CN 114867453 A CN114867453 A CN 114867453A
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Classifications
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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Abstract
本发明涉及一种易于水合并转化成最终用途洗涤组合物的各向同性浓缩组合物。由该浓缩组合物得到的最终用途洗涤组合物适用于局部应用和洗手。该浓缩物包含芳香油和乳化剂,所述芳香油和乳化剂的水平出乎意料地导致浓缩组合物和最终用途组合物不含干扰组合物的外观和使用的成分沉淀。
Description
技术领域
本发明涉及一种易于水合并转化成最终用途洗涤组合物的各向同性(isotropic)浓缩组合物。由该浓缩组合物得到的最终用途洗涤组合物适用于局部应用和用于洗涤,尤其是手。特别地,本发明涉及一种组合物,其至少在一个实施方式中优选不含硫酸盐,并且在使用时是温和的。此外,由浓缩物制成的最终用途组合物出人意料地能够明显起泡、是稳定的并且还具有胶束(各向同性)微结构。该浓缩物包含芳香油和乳化剂,所述芳香油和乳化剂的水平出乎意料地导致浓缩组合物和最终用途组合物不含干扰组合物的外观和使用的任何成分沉淀。这种最终用途组合物还提供了极好的感官益处。
背景技术
消费者寻求优选不含硫酸盐(即,没有基于硫酸盐的表面活性剂)并且温和且保湿的个人清洁组合物,同时即使在一次洗涤后也能提供优异的感官益处,如令人愉悦的泡沫和柔软、光滑的皮肤。在洗手时尤其如此,因为消费者受到鼓励以经常洗手而避免生病。
除此之外,有意识的消费者正在寻找机会减少环境废物,且特别是与塑料相关的废物,因为经常向人们宣传世界海洋很快就会拥有比鱼多的塑料。鉴于环境问题以及消费者和有意识的公司希望为地球做更多的事情,因此在销售产品(包括消费品)时,强烈希望减少使用塑料。因此,已努力以浓缩形式销售产品,并运送其中包含较少水的产品。浓缩物的困难在于消费者通常不喜欢向浓缩物中添加额外的水并且进一步操作,如搅拌,以将浓缩物转化成最终可用的产品。对于水合产品,常见的抱怨包括该产品的制备耗时、不均匀且颗粒状而在加水后和在使用过程中会出现沉淀。
开发一种带有可再填充包装的易于使用的且易于水合的浓缩物越来越引起人们的兴趣。还希望向消费者提供在五(5)分钟内即可使用并提供合意的感官特性而没有颗粒感的产品。本发明的浓缩物和最终用途组合物包含酰基羟乙基磺酸盐。已知这些表面活性剂是温和的表面活性剂。然而,含有高水平的酰基羟乙基磺酸盐和其他表面活性剂的组合物通常表现出成分沉淀(例如,结晶),这通常导致最终用途组合物对于消费者使用来说是不合需要的。因此,本发明涉及适合稀释成最终用途洗涤组合物的各向同性浓缩组合物,该最终用途洗涤组合物也是各向同性的。浓缩组合物包含芳香油和乳化剂,所述芳香油和乳化剂的水平使得稀释时出乎意料地导致不含成分沉淀的最终用途组合物,即当使用酰基羟乙基磺酸盐配制时。
附加信息
已经公开了制备洗涤组合物的努力。在Sun等(Journal of Cosmetic Science,54,559-568,2003)中,描述了含有酰基羟乙基磺酸盐和其他表面活性剂(如甲基酰基牛磺酸盐、酰基谷氨酸盐、酰基乳酸盐、烷基醚和二烷基磺基琥珀酸盐以及酰基肌氨酸盐)的洗涤组合物。
甚至已经公开了用于制备洗涤组合物的其他努力。在授予Lee等的US5,415,810中,公开了含有酰基羟乙基磺酸盐的洗涤液,该洗涤液还含有其它阴离子表面活性剂,如甲基酰基牛磺酸盐。
还公开了用于制备洗涤组合物的其他努力。在授予D'Angelo的US5,925,603中,公开了甲基酰基牛磺酸盐与酰基羟乙基磺酸盐的使用。
已经描述了用于制备洗涤组合物的进一步努力。在WO1992020776A1和EP0133345A1中,描述了液体洗手皂组合物。在US6,117,828中,描述了含有小麦蛋白的洗手组合物。
附加信息均未描述本文要求保护的浓缩组合物或最终用途组合物。
发明内容
在第一个方面中,本发明涉及各向同性浓缩组合物,其包含:
1)0.1至10%,优选0.5至6%,更优选1至4.5%重量的酰基羟乙基磺酸盐;
2)0.1至10%,优选0.5至6%,更优选1至4.5%重量的酰基牛磺酸盐;
3)0.2至25%,优选3.0至20%和更优选5至17%重量的两性和/或两性离子表面活性剂;
4)5.0至50%,优选10.0至40%,更优选20至30%重量的包含甘油的保湿剂;
5)0.7至8%,优选1.0至7%,更优选1.5至5%重量的芳香剂;
6)0.7至5%,优选1.0至4.5%,更优选1.2至4%重量的具有8至19,优选10至18,更优选12至17的HLB的乳化剂;和
7)25至80%,优选30至70%,更优选35至45%重量的水,
其中总表面活性剂构成各向同性浓缩组合物的12至35%,且优选15至30%,且最优选20至28%重量,并且进一步其中乳化剂和芳香剂为1:0.8至1:4,优选1:1至1:3,且更优选1:1.1至1:2的乳化剂比芳香剂的重量比。
在第二个方面中,本发明涉及通过将本发明的第一个方面的各向同性浓缩组合物水合制得的最终用途组合物,其中各向同性浓缩组合物与添加的水的重量比为1:1至1:6,优选1:1.5至1:5,最优选1:2至1:4。
在第三个方面中,本发明涉及最终用途组合物作为洗手组合物的用途,优选从可再填充包装分配的洗手组合物,并且更优选来自适于排出泡沫形式的洗手组合物的可再填充包装。
如本文所用的,没有限定词的“组合物”意指本发明的各向同性浓缩组合物和最终用途组合物。如本文所用的,可水合意指添加和/或添加并均匀吸收水至具有水的组合物(如最初为25至80%重量水的组合物)(即,稀释)。无成分沉淀是指在混合后至少1-3天,优选混合并形成最终用途组合物后2-3天,在本发明的最终用途组合物中没有可见的沉淀或晶体形成迹象(并且将组合物施用于皮肤时没有颗粒感)。如本文所用的,皮肤意指包括手臂(包括腋下)、面部、足部、颈部、胸部、手部、腿部、臀部和头皮(包括毛发)上的皮肤。各向同性浓缩组合物(“各向同性浓缩物”)是指向其中加入水时粘度不增加的各向同性组合物,以从而产生也是各向同性的并且适于局部施用的较低粘度的最终用途组合物。各向同性浓缩物是在水合前通常具有30至6,500cps粘度的组合物。最终用途组合物是适于擦拭或洗掉的组合物,且优选用水洗掉的组合物。最终用途组合物可以是家庭护理清洁组合物,但优选是洗发剂、卸妆用品、洗面奶、洗手液或个人护理液体沐浴露。最终用途组合物可以任选包含药用或治疗剂,但优选是美容和非治疗性的洗涤剂。在本发明的一个实施方式中,最终用途组合物是家庭护理组合物,如桌面或厕所清洁组合物。在另一个实施方式中,最终用途组合物是洗发剂组合物。在另一个实施方式中,最终用途组合物优选为个人洗涤组合物,且尤其是自起泡的并从可再填充包装分配的液体洗手液。如下文所述的,本发明的最终用途组合物可任选地包含加入其中的皮肤有益成分,如润肤剂、维生素和/或其衍生物、间苯二酚类、视黄酸前体、着色剂、保湿剂、防晒剂、其混合物等。皮肤有益成分(或试剂)可以是水溶性或油溶性的。如果使用的话,油溶性皮肤有益剂通常占最终用途组合物的1.5%重量,而水溶性皮肤有益剂在使用时通常占本发明最终用途组合物的10%重量。各向同性浓缩物和最终用途组合物通常具有4.5至10的pH。除非另有说明,否则粘度用Discovery HR-2流变仪使用具有100微米间隙的喷砂板和4-15s-1剪切速率进行测量。在25℃下测量粘度。粘度的降低意味着本发明的各向同性浓缩物的初始粘度高于加入水并制备所得最终用途组合物后的最终粘度。最终用途组合物通过将水和各向同性浓缩物组合并将其混合(用中等剪切,如搅拌,优选摇动)来制备,以产生粘度低于制备其的各向同性浓缩物的最终用途组合物。通常,最终用途组合物(如洗手组合物)将具有0.0至650cps的粘度。在另一个实施方式中,各向同性浓缩物可以直接施用于例如消费者,并且当施加水和剪切(如,例如,用手和来自水槽或淋浴器的水剪切)时,可以制备所需的最终用途组合物(即洗手液或沐浴液)。如本文所用的,“基本上不含硫酸盐”意指小于最终用途组合物的6.0%重量,并且“基本上不含油”意指小于最终用途组合物的0.3%重量,其中油不是指或包括任何芳香油。术语“包含”意在涵盖术语“基本上由……组成”和“由……组成”。为了避免疑义,并且为了说明,包含表面活性剂、水和活性物质的本发明的最终用途组合物意指包括基本上由其组成的组合物和由其组成的组合物。所定义的所有范围意在包括其中包含的所有范围。除了在操作比较例中,或在另外明确指出的情况下,否则本说明书中表示材料或条件的量或比率和/或材料的物理性质和/或用途的所有数字应理解为由词语“约”修饰。
具体实施方式
本发明的各向同性浓缩组合物将具有30至6,500cps,并且优选50至3,000cps,并且最优选100至1,500cps的粘度,包括其中包含的所有范围。关于最终用途组合物,其粘度为0.0至650cps,优选0至500cps,最优选0至250cps,包括其中包含的所有范围。最终用途组合物的粘度确保组合物可以从泵分配器排出,尤其是分配泡沫的分配器,而没有堵塞问题。令人惊讶地,在此类粘度下,最终用途组合物易于从分配器排出,同时令人惊讶地向消费者递送优异的感官益处。
关于阴离子表面活性剂,其总量通常占各向同性浓缩物的0.15至30%重量,包括其中包含的所有范围。在本发明的一个实施方式中,阴离子表面活性剂总计占各向同性浓缩物的0.5至16%重量,优选0.8至9%重量,包括其中包含的所有范围。在本发明的另一个实施方式中,所用的酰基羟乙基磺酸盐和酰基牛磺酸盐占本发明组合物中所用阴离子表面活性剂总量的75至100%,优选80至100%,且最优选85至100%重量。在本发明的任选实施方式中,除了酰基羟乙基磺酸盐和酰基牛磺酸盐(这两者均可在其头部基团上包含C1-4烷基取代基,特别是甲基)外,本发明组合物中阴离子表面活性剂的总量可包含0.01至7%重量的酰基甘氨酸盐。
关于各向同性浓缩物中使用的两性和/或两性离子表面活性剂,其通常占各向同性浓缩物的0.2至25%,且优选3至20%,且最优选5至17%重量,包括其中包含的所有范围。
为了例如有助于各向同性浓缩物的结构化和水合,可以优选使用结构化剂,如C6-C18酸和/或醇(即其衍生物),并且通常占各向同性浓缩物的0.1至3%,且优选0.2至2%,且最优选0.4至1.5%重量,包括其中包含的所有范围。优选的结构化剂是肉豆蔻酸、月桂酸、硬脂酸或其任何醇衍生物或其混合物。在本发明的一个实施方式中,结构化剂包含月桂酸和硬脂酸,月桂酸与硬脂酸的重量比为1:1至1:5,优选1:1至1:4,且最优选1:1至1:3,包括其中包含的所有比率。
无机盐是适用于帮助组合物感官特征递送的任选成分。可以使用的典型盐包括NaCl、KCl、MgCl2、CaCl2、其混合物等。通常,无机盐占各向同性浓缩物的0至8%,且优选0至6%,且最优选0.001至2%重量,包括其中包含的所有范围。
聚合物粘度助剂是适用于本发明的各向同性浓缩物中的任选成分。如果使用,优选的聚合物是通常分类为高分子量乙氧基化脂肪酸酯的那些。说明性实例包括PEG 120甲基葡萄糖二油酸酯、PEG 18甘油油酸酯/椰油酸酯、PEG 150季戊四醇四硬脂酸酯、其混合物等。通常优选的聚合物粘度助剂是PEG 150季戊四醇四硬脂酸酯,其由Croda以Versathix名称销售。如果使用,这些助剂占各向同性浓缩物的0.001至0.5%,优选0.001至0.3%,最优选0.01至0.2%重量,包括其中包含的所有范围。
在本发明的另一个实施方式中,在本发明的最终用途组合物中存在小于3.0重量%的硫酸盐,优选小于1.0重量%,且最优选不存在(0.0重量%)硫酸盐。因此,各向同性浓缩物应当配制为使得在稀释时,成分(例如,硫酸盐)处于在最终用途组合物中所需的水平。
关于适用于本发明的各向同性浓缩物和最终用途组合物中的阴离子表面活性剂(即,不仅使用酰基羟乙基磺酸盐和酰基牛磺酸盐时),所用的阴离子表面活性剂可包括脂族磺酸盐,如伯烷烃(例如,C8-C22)磺酸盐、伯烷烃(例如,C8-C22)二磺酸盐、C8-C22烯烃磺酸盐、C8-C22羟基烷烃磺酸盐或烷基甘油醚磺酸盐(AGS);或芳族磺酸盐,如烷基苯磺酸盐。该阴离子表面活性剂还可以是烷基硫酸盐(例如C12-C18烷基硫酸盐)或烷基醚硫酸盐(包括烷基甘油醚硫酸盐)。烷基醚硫酸盐包括具有下式的那些:
RO(CH2CH2O)nSO3M
其中R是具有8至18个碳,优选12至18个碳的烷基或烯基,n具有至少1.0,优选小于5,且最优选1至4的平均值,并且M是增溶阳离子,如钠、钾、铵或取代的铵。
该阴离子表面活性剂还可包括烷基磺基琥珀酸盐(包括单烷基和二烷基,例如C6-C22磺基琥珀酸盐);烷基和酰基牛磺酸盐(通常为甲基牛磺酸盐)、烷基和酰基肌氨酸盐、磺基乙酸盐、C8-C22烷基磷酸盐和膦酸盐、烷基磷酸酯和烷氧基烷基磷酸酯、酰基乳酸盐、C8-C22单烷基琥珀酸盐和马来酸盐、磺基乙酸盐、烷基葡糖苷和酰基羟乙基磺酸盐等。
磺基琥珀酸盐可以是具有下式的单烷基磺基琥珀酸盐:
R1O2CCH2CH(SO3M)CO2M
和下式的酰胺-MEA磺基琥珀酸盐:
R1CONHCH2CH2O2CCH2CH(SO3M)CO2M,其中R1范围为C8-C22烷基。
肌氨酸盐通常由下式表示:
R2CON(CH3)CH2CO2M,其中R2范围为C8-C20烷基。
使用的牛磺酸盐通常由下式表示:
R3CONR4CH2CH2SO3M,
其中R3是C8-C20烷基,R4是C1-C4烷基。
M是如前所述的增溶阳离子。
可以使用的羟乙基磺酸盐包括C8-C18酰基羟乙基磺酸盐(包括具有取代的头部基团的那些)。这些酯通过碱金属羟乙基磺酸盐与具有6至18个碳原子且碘值小于20的混合脂族脂肪酸之间的反应来制备。通常至少75%的混合脂肪酸具有12至18个碳原子,并且至多25%具有6至10个碳原子。
所用的酰基羟乙基磺酸盐可以是烷氧基化的羟乙基磺酸盐,如于1995年2月28日授权的Ilardi等的名称为“聚烷氧基化羟乙基磺酸的脂肪酸酯”的美国专利5,393,466号中所述的;在此引入作为参考。这种化合物具有以下通式:
R5C--O(O)--C(X)H--C(Y)H--(OCH2--CH2)m--SO3M
其中R5是具有8至18个碳的烷基,m是1至4的整数,X和Y各自独立地是氢或具有1至4个碳的烷基,并且M是如前所述的增溶阳离子。
在本发明的一个实施方式中,所用的阴离子表面活性剂是月桂酰甘氨酸钠、椰油酰基甘氨酸钠、月桂酰谷氨酸钠、椰油酰基谷氨酸钠、月桂酰基羟乙基磺酸钠、椰油酰羟乙基磺酸钠、甲基月桂酰基牛磺酸钠、甲基椰油酰基牛磺酸钠或其混合物。此类阴离子表面活性剂可从供应商如Galaxy Surfactants、Clariant、Sino Lion和Innospec商购获得。椰油酰基羟乙基磺酸钠、甲基月桂酰基牛磺酸钠、甲基月桂酰基羟乙基磺酸钠或其混合物是适合使用的优选阴离子表面活性剂。
适用于本发明的两性表面活性剂(其根据pH可以是两性离子的)包括酰基两性乙酸钠、酰基两性丙酸钠、酰基两性二乙酸二钠和酰基两性二丙酸二钠,其中酰基(即烷酰基)可以包含C7-C18烷基部分。适用的两性表面活性剂的说明性实例包括月桂酰两性乙酸钠、椰油酰两性乙酸钠、月桂酰两性乙酸钠、椰油酰两性乙酸钠及其混合物。
关于可用于本发明的两性离子表面活性剂,此类表面活性剂包括至少一个酸基团。这样的酸基团可以是羧酸或磺酸基团。它们通常包括季氮,因此可以是季氨基酸。它们通常应包括7至18个碳原子的烷基或烯基,通常符合总体结构式:
R6--[--C(O)--NH(CH2)q--]r--N+--(R7--)(R8)A--B,其中R7是7-18个碳原子的烷基或链烯基;R7和R8各自独立地为具有1至3个碳原子的烷基、羟烷基或羧基烷基;q为2至4;r为0至1;A是任选地被羟基取代的1至3个碳原子的亚烷基,并且B是--CO2--或--SO3--。
用于本发明并在上述通式内的合适的两性离子表面活性剂包括下式的简单甜菜碱:
R6--N+--(R7)(R8)CH2CO2 -
和下式的酰胺基甜菜碱:
R6--CONH(CH2)t--N+--(R7)(R8)CH2CO2 -,其中t是2或3。
在两个式中,R6、R7和R8如前定义。特别地,R6可以是源自椰子油的C12和C14烷基的混合物,使得至少一半,优选至少四分之三的基团R6具有10至14个碳原子。R7和R8优选是甲基。
另一种可能性是两性离子表面活性剂是下式的磺基甜菜碱:
R6--N+--(R7)(R8)(CH2)3SO3 -
或
R6--CONH(CH2)u--N+--(R7)(R8)(CH2)3SO3 -
其中u是2或3,或这些的变体,其中--(CH2)3SO3 -替换为--CH2C(OH)(H)CH2SO3 -。
在这些式中,R6、R7和R8如前定义。
适用的两性离子表面活性剂的说明性实例包括甜菜碱,如椰油二甲基羧甲基甜菜碱、椰油酰胺丙基甜菜碱和月桂酰胺丙基甜菜碱。适用的其他两性离子表面活性剂包括椰油酰胺丙基磺基甜菜碱。此类表面活性剂可从供应商如Stepan Company商购获得,并且使用上述表面活性剂的混合物在本发明的范围内。在优选实施方式中,本发明中使用的两性离子表面活性剂是椰油酰胺丙基甜菜碱。
在本发明的一个实施方式中,阳离子表面活性剂可任选地用于本发明的各向同性浓缩物和最终用途组合物中。
一类任选的阳离子表面活性剂包括杂环铵盐,如十六烷基或硬脂基氯化吡啶鎓、烷基酰胺乙基吡咯甲基硫酸盐和拉匹氯铵(lapyriumchloride)。
四烷基铵盐是另一类适用于任选使用的有用的阳离子表面活性剂。实例包括鲸蜡基或硬脂酰三甲基氯化铵或溴化铵;氢化棕榈或牛脂三甲基卤化铵;二十二烷基三甲基卤化铵或甲基硫酸铵;癸基异壬基二甲基卤化铵;二牛脂(或二硬脂酰)二甲基卤化铵和二十二烷基二甲基氯化铵。
可以使用的其它类型的阳离子表面活性剂是各种乙氧基化季胺和酯季铵盐。实例包括PEG-5硬脂酰乳酸铵(例如,由Clariant制造的Genamin KSL)、PEG-2椰油基氯化铵、PEG-15氢化牛脂氯化铵、PEG 15硬脂酰氯化铵、二棕榈酰乙基甲基氯化铵、二棕榈酰羟乙基甲基硫酸和硬脂酰胺丙基二甲胺乳酸。
适用于任选使用的更多其它有用的阳离子表面活性剂包括丝、小麦和角蛋白的季铵化水解产物,并且使用上述阳离子表面活性剂的混合物也在本发明的范围内。
如果使用,阳离子表面活性剂将占最终用途组合物的不超过1.0重量%。如果存在,它们通常占最终用途组合物的0.001至0.7%,且更通常0.01%至0.5%重量,包括其中包含的所有范围。
在本发明的一个实施方式中,本发明的组合物将基本上不含聚合季铵化合物(包括其盐)。在另一个实施方式中,最终用途组合物将包含小于0.1%重量的聚合季铵化合物。在又一个实施方式中,最终用途组合物包含小于0.01%重量的聚合季铵化合物。在甚至另一个实施方式中,各向同性浓缩物和最终用途组合物不含聚合季铵化合物(即0.0%)。
水优选占前述各向同性浓缩物的25至80重量%,包括其中包含的所有范围。
各向同性组合物和最终用途组合物的pH通常为4.5至10,且优选5至9,且最优选5.2至7.5,包括其中包含的所有范围。可以使用适于调节/缓冲pH的调节剂。这类pH调节剂包括三乙胺、NaOH、KOH、H2SO4、HCl、C6H8O7(即柠檬酸)或其混合物。pH调节剂以产生所需最终pH的量加入。pH值可以用商业仪器评估,如可从Thermo 公司商购获得的pH计。
适用于本发明的任选皮肤有益剂仅限于它们能够局部施用的程度,并且适于在所需pH下溶解在可水合组合物和最终用途组合物中。
适合包含在组合物的水部分中的有益剂的说明性实例是酸,如氨基酸,如精氨酸、缬氨酸或组氨酸。适用的其他水溶性有益剂包括维生素B2、烟酰胺(维生素B3)、维生素B6、维生素C、及其混合物等。也可以使用这些维生素的水溶性衍生物。例如,维生素C衍生物,如抗坏血酸四异棕榈酸酯、抗坏血酸磷酸镁和抗坏血酸糖苷,可以单独使用或彼此组合使用。适用的其它水溶性有益剂包括4-乙基间苯二酚、提取物如鼠尾草、芦荟、绿茶、葡萄籽、百里香、洋甘菊、蓍草、黄瓜、甘草、迷迭香提取物,或其混合物。也可以使用水溶性防晒剂,如恩索利唑。存在于本发明中时,任选的水溶性有益剂(包括混合物)的总量可在0.0至10%,优选0.001至8%,并且最优选0.01至6%重量的范围内,基于最终用途组合物的总重量,并且包括其中包含的所有范围。
任选地包括油(即非水)溶性有益剂也在本发明的范围内。最终用途组合物基本上不含油,并且优选具有小于0.15重量%的油,并且最优选不含油(0.0%)。因此,油溶性活性物质或有益剂溶解在所用的表面活性剂中。关于此类油溶性有益剂的唯一限制是当局部施用时,其适于提供益处。
可任选用于本发明组合物中的油溶性有益剂类型的说明性实例包括以下组分,如硬脂酸、维生素如维生素A、D、E和K(及其油溶性衍生物)、防晒剂如甲氧基肉桂酸乙基己酯、双乙基己氧基苯酚甲氧基苯酚三嗪、2-乙基己基-2-氰基-3,3-二苯基-2-丙酸、甲酚曲唑三硅氧烷、3,3,5-三甲基环己基2-羟基苯甲酸酯、2-乙基己基-2-羟基苯甲酸酯或其混合物。
适用的其它任选的油溶性有益剂包括间苯二酚类,如4-己基间苯二酚、4-苯乙基间苯二酚、4-环戊基间苯二酚、4-环己基间苯二酚、4-异丙基间苯二酚或其混合物。此外,可以使用5-取代的间苯二酚类,如4-环己基-5-甲基苯-1,3-二醇、4-异丙基-5-甲基苯-1,3-二醇、其混合物等。5-取代的间苯二酚类及其合成描述于共同受让的美国公开专利申请No.2016/0000669A1中。
适用的更多其它油溶性活性物质包括ω-3脂肪酸、ω-6脂肪酸、氯咪巴唑、法呢醇、熊果酸、肉豆蔻酸、香叶基香叶醇、油基甜菜碱、椰油酰羟乙基咪唑啉、己酰基鞘氨醇、12-羟基硬脂酸、岩芹酸、共轭亚油酸、萜品醇、百里酚、其混合物等。
在本发明的一个实施方式中,所用的任选的油溶性有益剂是视黄酸前体。在本发明的一个实施方式中,视黄酸前体视黄醇是视黄醇、视黄醛、视黄醇丙酸酯、视黄醇棕榈酸酯、视黄醇乙酸酯或其混合物。视黄醇丙酸酯、视黄醇棕榈酸酯及其混合物通常是优选的。
适用的另一种视黄酸前体是由Molecular Design International提供的以名称市售可得的羟基茴香酯(hydroxyanasatil)视黄酸。其可以与本文所述的油溶性活性物质混合使用。
在本发明的最终用途组合物中使用任选的(即0.0至1.5%重量)油溶性活性物质时,其通常占最终用途组合物总重量的0.001至1.5%重量,且在另一个实施方式中,0.05至1.2%重量,和在又一个实施方式中,0.1至0.5%重量,包括其中包含的所有范围。
可理想地将防腐剂掺入可水化浓缩物和最终用途组合物中以防止潜在有害微生物的生长。化妆品化学家熟悉合适的防腐剂,并且通常选择它们以满足防腐剂挑战测试并提供产品稳定性。适用的传统防腐剂包括乙内酰脲衍生物和丙酸盐。特别优选的防腐剂是碘代丙炔基丁基氨基甲酸酯、苯氧基乙醇、1,2-辛二醇、羟基苯乙酮、乙基己基甘油、己二醇、对羟基苯甲酸甲酯、对羟基苯甲酸丙酯、咪唑烷基脲、脱氢乙酸钠、二甲基-二甲基(DMDM)乙内酰脲和苄醇,及其混合物。适用的其它防腐剂包括脱氢乙酸钠、氯苯甘醚和癸二醇。防腐剂的选择应考虑到组合物的用途以及防腐剂与乳液中其他成分之间可能的不相容性。防腐剂优选以最终用途组合物总重的0.01%至2.0%重量范围(至多总各向同性浓缩物的7%重量)的量使用,包括其中包含的所有范围。还优选的是具有单独的羟基苯乙酮或与其他防腐剂的混合物的防腐剂体系。
增稠剂任选地适用于本发明的组合物中。特别有用的是多糖。实例包括纤维、淀粉、天然/合成树胶和纤维素制品。代表性的淀粉是化学改性淀粉,如羟丙基淀粉磷酸钠和淀粉辛烯基琥珀酸铝。通常优选木薯淀粉,麦芽糖糊精也是如此。合适的树胶包括黄原胶、菌核、果胶、刺梧桐树胶、***胶、琼脂、瓜尔胶(包括塞内加尔***胶)、角叉菜胶、藻酸盐及其组合。合适的纤维素制品包括羟丙基纤维素、羟丙基甲基纤维素、乙基纤维素、羧甲基纤维素钠(纤维素胶/羧甲基纤维素)和纤维素(例如纤维素微纤丝、纤维素纳米晶体或微晶纤维素)。纤维素微纤丝的来源包括次生细胞壁材料(例如木浆、棉花)、细菌纤维素和初生细胞壁材料。优选地,初生细胞壁材料的来源选自来自果实、根、鳞茎、块茎、种子、叶及其组合的薄壁组织;更优选选自柑橘类果实、番茄果实、桃果实、南瓜果实、猕猴桃果实、苹果果实、芒果果实、糖用甜菜、甜菜根、芜菁、欧洲防风草、玉米、燕麦、小麦、豌豆及其组合;并且甚至更优选地选自柑橘类果实、番茄果实及其组合。初生细胞壁材料的最优选来源是来自柑橘果实的薄壁组织。柑橘类纤维,如可由以AQ Plus获得的那些,也可用作纤维素微纤丝的来源。纤维素来源可以通过任何已知方法进行表面改性,包括在Colloidal Polymer Science,Kalia等,“Nanofibrillated cellulose:surfacemodification and potential applications”(2014),第292卷,第5-31页中描述的那些。
除了聚合物粘度助剂外,合成聚合物是可任选使用的另一类有效增稠剂。这个类别包括交联的聚丙烯酸酯,如卡波姆、聚丙烯酰胺,如305和牛磺酸共聚物,如EG和AVC,所述共聚物通过各自的INCI命名法确定为丙烯酸酯钠/丙烯酰二甲基牛磺酸钠和丙烯酰二甲基牛磺酸/乙烯基吡咯烷酮共聚物。适用于增稠的另一种优选的合成聚合物是由Seppic市售并以名称Simulgel INS100销售的基于丙烯酸酯的聚合物。还可以使用碳酸钙、热解法二氧化硅和硅酸镁铝。
使用时,任选的增稠剂的量可以为组合物重量的0.001%至6%。麦芽糊精、黄原胶和羧甲基纤维素是通常优选的任选增稠剂。
固定剂、螯合剂(如EDTA)和去角质剂可任选地包括在本发明的组合物中。这些物质中的每一种可以在最终用途组合物总重量的约0.03至约5%,优选0.1至3重量%的范围内,包括其中包含的所有范围。在使用去角质剂的情况下,选择的那些应具有足够小的粒度,使得它们不妨碍用于分配本发明组合物的任何包装的性能。
关于本发明中使用的乳化剂,这些乳化剂的HLB为8至19。说明性实例包括吐温40、吐温60、吐温80、聚山梨醇酯20(HLB 16.7)、PEG-100硬脂酸酯、椰油酰胺MEA、PEG-8油酸酯、月桂醇聚醚-23或其混合物。本发明的各向同性浓缩物中的乳化剂将占各向同性浓缩物的0.7至5%重量,包括其中包含的所有范围。如本文所用的,聚山梨醇酯20在本文中被定义为乳化剂,并且常常是本发明组合物中的优选乳化剂。
除了甘油之外的常规保湿剂可以用作本发明中的添加剂,以在局部施用最终用途组合物时帮助皮肤保湿。这些通常是多元醇型材料。除甘油之外的典型多元醇包括丙二醇、二丙二醇、聚丙二醇(例如PPG-9)、聚乙二醇、山梨糖醇、羟丙基山梨糖醇、己二醇、1,3-丁二醇、异戊二醇、1,2,6-己三醇、乙氧基化甘油、丙氧基化甘油及其混合物。最优选的是至少75%重量甘油的保湿剂,基于组合物中保湿剂的总重量计。丙二醇和甘油的混合物通常是优选的,其中基于保湿剂中聚丙二醇和甘油的总重量,这种混合物为5至15%,优选6至12%重量的丙二醇。除了甘油之外,所用的保湿剂的量可以在最终用途组合物总重量的0.0%至35%重量的范围内。通常,另外的保湿剂占最终用途组合物总重量的0.0至20%,且优选0.001至15%重量(最优选2至12%重量)。
关于本发明的各向同性浓缩物,其通常具有5至50%重量的保湿剂,包括其中包含的所有范围。在本发明的一个实施方式中,用于各向同性浓缩物和最终用途组合物中的总保湿剂的至少85%重量,且优选90至100%重量是甘油。
用于本发明的芳香剂包括本领域公认的适用于局部施用的组合物中的芳香剂。此类芳香剂可包括如橙花叔醇、香叶醇、萜品油烯、芳樟醇、萜品烯、柠檬烯、蒎烯、莰烯、香茅醇、香茅醛、香叶醇、香草醛、萜品醇、百里酚、丁子香酚、薰衣草油、鼠尾草油、橙花油、迷迭香油、姜油、柠檬油、百里香油、乙酸萜品酯、其混合物等的组分。出乎意料地,已经发现了在将常规芳香剂与如本发明所述的乳化剂一起使用时,本发明的各向同性浓缩物和最终用途组合物不含成分沉淀。通常,各向同性浓缩物将包含0.7至8%重量的芳香剂,包括其中包含的所有范围。
本发明涉及在与水混合时粘度降低的各向同性浓缩组合物。
当制备本发明的各向同性浓缩组合物时,所需成分可以用常规设备在中等剪切和大气条件下混合,使用35℃至80℃的温度。将水加入各向同性浓缩组合物中以产生最终用途组合物。在容器中适度的剪切,如摇动(或搅拌),将在少于5分钟内,优选在少于3分钟内,且最优选在少于2分钟内产生最终用途组合物。在本发明的一个实施方式中,最终用途组合物在小于1分钟,甚至优选小于30秒内制备。
组合物的包装通常不受限制,只要各向同性浓缩组合物可以水合并且最终用途组合物可以在水加入时制备即可。在本发明的一个实施方式中,各向同性浓缩物在与瓶子或罐相关联并***瓶子或罐中的小袋或药筒中出售。瓶子或罐是填充有水的瓶子或罐,并且允许将浓缩物释放到瓶子或罐中以与水混合。通常,瓶子或罐具有带有泵的盖子,该泵打开小袋或罐以将浓缩物释放到水中而制备最终用途组合物。这种浓缩物出乎意料地产生最终用途组合物,如洗手液,其具有消费者所欣赏的期望特性并且没有沉淀或颗粒性。这种包装允许无限次的再填充,以始终减少环境中的塑料浪费。包装还可以在其出口孔中配备有网孔配件,以释放泡沫形式的最终用途组合物。在离开泵之前具有35至140微米的孔的网孔的常规泵可从供应商(如Albea和Rieke)商购获得。
所提供的实施例是为了便于理解本发明。它们不旨在限制权利要求的范围。
实施例I
表中列出的这个实施例中所示的组合物通过常规方法制备,并因此通过在大气条件下在约35至75℃的温度下以中等剪切混合成分来制备。所得各向同性浓缩物的pH为约6.9,且粘度为约100cps。
表
每1份浓缩物用3份水水合/稀释各向同性浓缩组合物。在1分钟内利用搅拌制备的所得最终用途组合物是适用于可再填充包装的可起泡洗手组合物。洗手组合物的粘度为约50cps。令人惊讶的是,在室温(25℃)下48至72小时后,浓缩物和洗手组合物都未显示任何可见的或物理的沉淀或结晶迹象。此外,向常规泡沫泵分配器中加入本发明的洗手组合物。在没有沉淀物堵塞迹象的情况下,泵分配器通过约100微米的筛网每泵排出约100微升洗手组合物,从而产生泡沫洗手组合物。
实施例II
在这个实施例中,制备了与实施例I中制备的浓缩物类似的各向同性浓缩组合物,不同之处在于不包含芳香剂和乳化剂,余量为水。最终用途组合物也通过以实施例I中所述的方式稀释浓缩物来制备。在这个实施例中制备的所得的浓缩物和最终用途组合物在室温(25℃)下在小于24小时内显示出沉淀/结晶。两者对于消费者使用都是不可接受的。
Claims (9)
1.一种各向同性浓缩组合物,其包含:
i)0.1至10%,优选0.5至6%,更优选1至4.5%重量的酰基羟乙基磺酸盐;
ii)0.1%至10%,优选0.5至6%,更优选1至4.5%重量的酰基牛磺酸盐;
iii)0.2至25%,优选3.0至20%,更优选5至17%重量的两性和/或两性离子表面活性剂;
iv)5.0至50%,优选10.0%至40%,更优选20至30%重量的包含甘油的保湿剂;
v)0.7至8%,优选1.0至7%,更优选1.5至5%重量的芳香剂;
vi)0.7至5%,优选1.0至4.5%,更优选1.2至4%重量的乳化剂,其HLB为8至19,优选10至18,更优选12至17;和
vii)25至80%,优选30至70%,更优选35至45%重量的水,
其中总表面活性剂占所述各向同性浓缩组合物的12至35%,且优选15至30%,且最优选20至28%重量,并且进一步其中乳化剂与芳香剂的重量比为1:0.8-1:4,优选1:1-1:3,且更优选1:1.1-1:2。
2.根据权利要求1所述的各向同性浓缩组合物,其中所述各向同性浓缩组合物具有30至6,500cps的粘度和4.5至10的pH。
3.根据之前任一项权利要求所述的各向同性浓缩组合物,其中所述酰基羟乙基磺酸盐是椰油酰基羟乙基磺酸钠,并且所述酰基牛磺酸盐是甲基月桂酰基牛磺酸钠,所述各向同性浓缩组合物具有50至3,000cps的粘度。
4.一种通过使前述任一项权利要求所述的各向同性浓缩组合物水合而制备的最终用途组合物,其中所述各向同性浓缩组合物与用于水合的水的重量比为1:1至1:6,优选1:1.5至1:5,更优选1:2至1:4。
5.根据之前任一项权利要求所述的最终用途组合物,其中所述最终用途组合物是适用于可再填充包装中的洗手组合物。
6.根据之前任一项权利要求所述的最终用途组合物,其中所述洗手组合物是可起泡的洗手组合物。
7.根据之前任一项权利要求所述的最终用途组合物,其中所述最终用途组合物不含沉淀物。
8.根据之前任一项权利要求所述的最终用途组合物,其中所述乳化剂包含聚山梨醇酯20。
9.根据之前任一项权利要求所述的最终用途组合物,其中所述最终用途组合物是通过在一分钟内将水和所述各向同性浓缩组合物混合而制备的洗手组合物,由此所述最终用途组合物是各向同性的。
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