CN114831119A - Solid-liquid combined peroxyacetic acid disinfectant and preparation method thereof - Google Patents
Solid-liquid combined peroxyacetic acid disinfectant and preparation method thereof Download PDFInfo
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- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
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- A—HUMAN NECESSITIES
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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Abstract
The invention relates to a solid-liquid combined peroxyacetic acid disinfectant and a preparation method thereof, relates to the technical field of disinfectant, and is mainly used for disinfection and sterilization of a soft endoscope. The use is convenient, A, B can be mixed, dissolved and diluted, sterilization can be achieved within 10min, and disinfection can be achieved within 5 min. Can kill intestinal pathogenic bacteria, pyococcus, pathogenic yeast, bacterial spore, Aspergillus niger and Mycobacterium cheloniae, and can inactivate virus. The paint not only has the effects of high efficiency, broad spectrum and quick effect, but also has good safety, simple and convenient and quick use and no corrosion. Particularly, the agent B in the composition is solid powder and A, B of the agent B is a concentrated solution after being mixed and dissolved, so that the agent B can be diluted by 6 times for use, and the logistics cost is saved. Is suitable for high-level disinfection and sterilization of various medical instruments, endoscopes and the like in medical and health institutions.
Description
Technical Field
The invention relates to the technical field of disinfection, in particular to a solid-liquid combined peroxyacetic acid disinfectant and a preparation method thereof.
Background
The information in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.
Peracetic acid is a disinfectant (sterilizing) agent belonging to peroxides, is an internationally recognized high-level disinfectant and sterilizing agent, has the advantages of ensured sterilizing effect, high efficiency, no residue, environmental protection and the like, and has the sterilizing mechanism of oxidizing protein in bacteria so as to kill microorganisms. The peroxyacetic acid commonly used in the market at present is a product packaged by unit peroxyacetic acid, liquid A and liquid B, has the defects of strong corrosivity, large smell and the like, is generally used as stock solution, and has high logistics cost.
Disclosure of Invention
In order to solve the technical problems, the invention provides a solid-liquid combined peroxyacetic acid disinfectant and a preparation method thereof. The peroxyacetic acid disinfectant is convenient to use, and can be sterilized after being mixed, dissolved and diluted by A, B for 10min and achieve a sterilizing effect in 5 min. Can kill intestinal pathogenic bacteria, pyococcus, pathogenic yeast, bacterial spore, Aspergillus niger and Mycobacterium cheloniae, and can inactivate virus. The paint not only has the effects of high efficiency, broad spectrum and quick effect, but also has good safety, simple and convenient and quick use and no corrosion. Particularly, the agent B in the composition is solid powder and A, B of the agent B is a concentrated solution after being mixed and dissolved, so that the agent B can be diluted by 6 times for use, and the logistics cost is saved. Is suitable for high-level disinfection and sterilization of various medical instruments, endoscopes and the like in medical and health institutions.
The invention is realized by the following technical scheme:
a solid-liquid combined peroxyacetic acid disinfectant consists of two parts, namely a liquid A and a powder B, wherein the liquid A consists of 220 parts by weight of 50% hydrogen peroxide 160-220 parts, 0.1-1 part by weight of a stabilizer, 0.01-2 parts by weight of a corrosion inhibitor, 0.5-5 parts by weight of a pH buffer and the balance of purified water; the B powder consists of 1.0 to 3.5 parts of activator, 0.01 to 0.1 part of defoamer, 0.01 to 1 part of cosolvent and 1.0 to 2.5 parts of catalyst; the above components are 1000 parts in total.
The stabilizer is one or more of EDTA, sodium aminotrimethylene phosphonate, HEDP disodium, sodium silicate, sodium benzoate and the like.
The corrosion inhibitor is one or more of sodium silicate, sodium tungstate, sodium molybdate, sodium gluconate, benzotriazole and sodium 2-hydroxyphosphonoate.
The pH buffering agent is one or more of disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium phosphate, potassium dihydrogen phosphate, sodium acetate and the like.
The stability of the peroxyacetic acid content after the reaction can be ensured by adding a pH buffering agent.
The activating agent is one or more of TAED, sodium acetylsalicylate, sodium nonanoyloxy benzene sulfonate and caprolactam chloride.
The defoaming agent is one or a combination of block polyether, polydimethylsiloxane, silicon ether copolymer and octanol.
The cosolvent is one or a combination of sodium dodecyl benzene sulfonate, sodium dodecyl sulfate and sodium dodecyl sulfate.
The surfactant is used as a cosolvent, so that the surface tension of the liquid part is reduced, the uniform dispersion and dissolution speed of the solid part in the liquid part are increased, and the rapid solid-liquid reaction is facilitated.
The catalyst is one or more of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate and tetra sodium hydroxyethylidene diphosphonate.
The presence of the catalyst can provide good reaction conditions of the activator and the hydrogen peroxide, and improve the reaction speed of the activator and the hydrogen peroxide.
And the solution A and the powder B are respectively and independently packaged, and are mixed, activated and diluted for use when in use.
The preparation method of the solid-liquid combined peroxyacetic acid disinfectant comprises the following steps:
s1, weighing 50% of hydrogen peroxide raw material, stabilizer, corrosion inhibitor, pH buffer and purified water to form solution A;
s2, weighing an activating agent, a defoaming agent, a cosolvent and a catalyst to form powder B;
s3, adding the raw materials of the solution A into a mixing tank, and stirring to uniformly mix the raw materials;
s4, adding the raw material powder of the powder B into a mixer, and mixing at normal temperature to fully and uniformly mix the raw material powder;
s5, respectively packaging the solution A and the powder B;
s6, when in use, adding the powder B into the solution A, stirring to completely dissolve the powder B to generate enough peroxyacetic acid, and then diluting with purified water until the content of the peroxyacetic acid is more than 0.2%.
In the step S3, the stirring time is 0.5h-2 h;
in step S4, the mixing time is 25-30 minutes.
The invention has the beneficial effects that:
1. the peracetic acid disinfectant disclosed by the invention is a solid-liquid combination, wherein the agent B in the combination is solid powder, and A, B components are mixed and dissolved to form a concentrated solution, so that the concentrated solution can be diluted by 6 times for use, and the logistics cost is saved. The solid-liquid combination mode does not need to add glacial acetic acid, so that the smell of the disinfectant can be reduced to a great extent, and the use experience of medical care personnel is effectively improved. And solid-liquid binary packaging is adopted, so that the stability of the product in the storage and transportation process can be effectively ensured. The invention is concentrated solution after solid-liquid reaction, and is diluted by adding water at the use place according to the proportion of 1:5 for use, thereby greatly saving logistics cost and reducing use cost.
2. When the solid-liquid combined peroxyacetic acid disinfectant prepared by the method is used, the powder B is added into the liquid A and stirred to be completely dissolved, and then the solution is diluted by purified water until the content of the peroxyacetic acid is more than 0.2 percent and the pH value is 6.0-7.0, so that intestinal pathogenic bacteria, pyogenic cocci, pathogenic saccharomycetes, common bacteria and bacterial spores infected by hospitals can be killed, and the solid-liquid combined peroxyacetic acid disinfectant is used for disinfecting and sterilizing various multiplexing medical instruments, endoscopes and the like.
3. The solid-liquid combined peroxyacetic acid disinfectant prepared by the method has strong stability, 50 percent of hydrogen peroxide, a stabilizer, a corrosion inhibitor, a pH buffering agent and purified water form solution A, an activating agent, a defoaming agent, a cosolvent and a catalyst form powder B, and the components of the solution A and the powder B are properly designed, so that the peroxyacetic acid disinfectant is more stable, and the reduction rate of the peroxyacetic acid at 54 ℃ for 14 days is as follows: 3.41 percent, 90 days at 37 ℃, the reduction rate of the peroxyacetic acid is 6.21 percent, and the effective period can be set as 24 months.
4. The solid-liquid combined peroxyacetic acid disinfectant prepared by the method is mild in property by adding 50% of hydrogen peroxide, a pH buffering agent, a corrosion inhibitor and the like, and has good compatibility with many materials: the paint has no corrosion to stainless steel, copper and carbon steel basically, and is corrosion resistant to common nonmetal materials such as endoscopes.
5. The solid-liquid combined peroxyacetic acid disinfectant prepared by the method can be used for disinfecting the endoscope for 14 days at most after being diluted. 140 endoscopes can be sterilized.
6. The peroxyacetic acid disinfectant is convenient to use, A, B is mixed, dissolved and diluted, the disinfectant can be sterilized in 10min, and the disinfection effect can be achieved in 5 min. The paint not only has the effects of high efficiency, broad spectrum and quick effect, but also has good safety, simple and convenient and quick use and no corrosion. Is suitable for high-level disinfection and sterilization of various medical instruments, endoscopes and the like in medical and health institutions.
Detailed Description
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The invention aims to provide a solid-liquid combined peroxyacetic acid disinfectant and a preparation method thereof. In order to achieve the purpose, the invention is realized by the following technical scheme: a solid-liquid combined peroxyacetic acid disinfectant is prepared from the following materials: 1000g of disinfectant is prepared and consists of two parts, namely solution A and powder B. Wherein the solution A comprises 220g of 50% hydrogen peroxide 160-; the B powder consists of 1.0-3.5g of activator, 0.01-0.1g of defoamer, 0.01-1g of cosolvent and 1.0-2.5g of catalyst.
The invention is further illustrated by the following examples
Example 1
S1, weighing 160g of 50% hydrogen peroxide raw material, 0.3g of EDTA0.3g of benzotriazole, 0.5g of disodium hydrogen phosphate and 836.55g of purified water to form solution A.
S2, weighing 1.0g of TAEDs, 0.05g of defoaming agents, 0.05g of sodium dodecyl benzene sulfonate and 1.5g of sodium carbonate to form powder B;
and (3) adding the raw materials of the solution A into a batching tank, and stirring for 1h to uniformly mix the raw materials.
Adding raw material powder of S4 and B powder into a mixer, and mixing for 25-30 minutes at normal temperature to fully mix the raw materials uniformly;
and S5, packaging the materials of the liquid A and the powder B respectively.
S6, when in use, adding the powder B into the solution A, stirring to completely dissolve the powder B, generating enough peroxyacetic acid, and then diluting with purified water until the content of the peroxyacetic acid is more than 0.2%.
1) Stability:
dissolving in water, and determining the peroxyacetic acid content as follows: 0.25%%. Referring to the stability test method of the disinfection technical Specification (2002 edition), after the binary package is placed at 54 ℃ for 14 days, the peroxyacetic acid content is 0.24 percent, the reduction rate is 4.00 percent, and after the temperature is 37 ℃ for 90 days, the available chlorine content is as follows: 0.235%, the reduction rate is: 6.0 percent. The stability and the validity period of the formula reach 24 months.
2) Corrosiveness of metal
Referring to a metal corrosion detection method in disinfection technical Specification (2002 edition), the corrosion rates of copper, aluminum, carbon steel and stainless steel are respectively determined as follows: 0.0006, 0.0023, 0.0107, 0.000 on a corrosion scale of substantially no corrosion, mild corrosion, moderate corrosion, and substantially no corrosion, respectively. Meets the relevant requirements of medical instrument disinfection.
3) Corrosive nature of endoscope material
For non-metallic materials: the mass increases after soaking in polycarbonate (PC-110), polyurethane (TPU), silicone, rubber, high borosilicate glass, Polysulfone (PSU), Polyamide (PA), polyester fiber (PET), Polystyrene (PS), Polyetheretherketone (PEEK), HDPE, Polytetrafluoroethylene (PTFE) for 72h are respectively-0.06%, -0.42%, -0.18%, -0.16%, -0.05%, 0.39%, 0.41%, 0.18%, 1.03%, 0.19% and 0.17%, and the materials are all corrosion resistant.
4) Killing effect on Bacillus subtilis var niger spores (as shown in Table 1)
TABLE 1 Effect on Bacillus subtilis var niger
And (4) conclusion: the sample acts for 5min and 7.5min at the concentration of 0.25% +/-0.05% to disinfect Bacillus subtilis var niger on a stainless steel sheet.
5) Qualitative Sterilization test results for Bacillus subtilis var niger spores (as shown in Table 2)
TABLE 2 qualitative sterilization test results for Bacillus subtilis var niger spores
And (4) conclusion: the sample acts for 5min, 10min and 15min at the concentration of 0.25% +/-0.05% to sterilize the black variant bacillus of bacillus subtilis on the stainless steel sheet.
6) Simulation of endoscope sterilization on-site test-sterilization time: 5min (as shown in Table 3)
TABLE 3 simulated in-situ test for endoscope sterilization
Note 1. the average value and range of the colony number recovered from the positive control group are 1.62X 106 CFU/sample, 1.59X 106 CFU/sample-1.42X 106 CFU/sample. Negative control was grown aseptically.
And (4) conclusion: the sample is disinfected and qualified for 5min under the condition that the concentration of the sample is 0.25% + -0.05% and the Bacillus subtilis var niger on a simulated endoscope tube.
7) Simulated sterilization test of endoscope-time: 10min (as shown in Table 4)
TABLE 4 simulated sterilization test for endoscope sterilization
Note 1. the average value and range of the number of colonies recovered from the positive control group are 1.34X 106 CFU/sample,
1.48X 106 CFU/sample to 1.65X 106 CFU/sample.
2. Negative control was grown aseptically.
"-" represents sterile growth.
And (4) conclusion: the sample is sterilized for 10min to be qualified under the condition of 0.25% +/-0.05% concentration to bacillus subtilis black variant spore bacteria on a simulated endoscope tube.
Example 2
S1, weighing 180g of 50% hydrogen peroxide raw material, 0.5g of HEDP disodium, 0.1g of benzotriazole, 0.3g of trisodium phosphate and 814.8g of purified water to form solution A.
S2, weighing 2.0g of sodium acetylsalicylate, 0.05g of defoaming agent, 0.3g of sodium dodecyl benzene sulfonate and 2.0g of sodium bicarbonate to form powder B;
and S3, adding the raw materials of the liquid A into a mixing tank, and stirring for 1h to uniformly mix the materials.
S4, adding the raw material powder of the powder B into a mixer, and mixing for 25-30 minutes at normal temperature to fully and uniformly mix the raw materials;
and S5, packaging the materials of the liquid A and the powder B respectively.
S6, when in use, adding the powder B into the solution A, stirring to completely dissolve the powder B, generating enough peroxyacetic acid, and then diluting with purified water until the content of the peroxyacetic acid is more than 0.2%.
1) Stability:
dissolving in water, and determining the peroxyacetic acid content as follows: 0.26%%. Referring to the stability detection method of disinfection technical Specification (2002 edition), after the binary package is placed at 54 ℃ for 14 days, the peroxyacetic acid content is 0.245%, the reduction rate is 5.77%, and after the temperature is 37 ℃ for 90 days, the active ingredient content is as follows: 0.239%, the reduction rate is: 8.08 percent. The stability and the validity period of the formula reach 24 months.
2) Corrosiveness of metal
Referring to a metal corrosion detection method in disinfection technical Specification (2002 edition), the corrosion rates of copper, aluminum, carbon steel and stainless steel are respectively determined as follows: 0.0009, 0.0043, 0.0125 and 0.000, and the corrosion grades are basically no corrosion, light corrosion, medium corrosion and basically no corrosion respectively. Meets the relevant requirements of medical instrument disinfection.
3) Corrosive nature of endoscope material
For non-metallic materials: the mass increases after soaking polycarbonate (PC-110), polyurethane (TPU), organosilicon, rubber, high borosilicate glass, Polysulfone (PSU), Polyamide (PA), polyester fiber (PET), Polystyrene (PS), Polyetheretherketone (PEEK), HDPE, Polytetrafluoroethylene (PTFE) for 72 hours are respectively-0.09%, -0.52%, -0.16%, -0.14%, -0.07%, 0.42%, 0.45%, 0.21%, 1.18%, 0.14%, 0.23% and 0.15%, and the materials are all corrosion resistant.
4) Killing effect on Bacillus subtilis var niger spores (as shown in Table 5)
TABLE 5 Effect on Bacillus subtilis var niger
And (4) conclusion: the sample acts for 5min and 7.5min at the concentration of 0.25% +/-0.05% to disinfect Bacillus subtilis var niger on a stainless steel sheet.
5) Qualitative Sterilization test results for Bacillus subtilis var niger spores (as shown in Table 6)
TABLE 6 qualitative sterilization test results for Bacillus subtilis var niger spores
And (4) conclusion: the sample acts for 5min, 10min and 15min under the concentration of 0.25% +/-0.05% to sterilize Bacillus subtilis var niger on the stainless steel sheet.
8) Simulation of endoscope sterilization on-site test-sterilization time: 5min (as shown in representation 7)
TABLE 7 simulated in situ test for endoscope sterilization
Note: 1. average value and range of colony number recovered from positive control group is 1.58X 106 CFU/sample,
1.63X 106 CFU/sample to 1.39X 106 CFU/sample.
2. Negative control was grown aseptically.
And (4) conclusion: the sample is disinfected and qualified for 5min under the condition that the concentration of the sample is 0.25% + -0.05% and the Bacillus subtilis var niger on a simulated endoscope tube.
9) Simulated sterilization test of endoscope-time: 10min (as shown in Table 8)
TABLE 8 simulated sterilization test for endoscope sterilization
Note that 1, the average value and range of the colony number recovered by the positive control group are 1.48 × 106 CFU/sample, 1.37 × 106 CFU/sample-1.65 × 106 CFU/sample.
2. Negative control was grown aseptically.
3. "-" represents sterile growth.
And (4) conclusion: the sample is sterilized for 10min to be qualified under the condition of 0.25% +/-0.05% concentration to bacillus subtilis black variant spore bacteria on a simulated endoscope tube.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. A solid-liquid combined peracetic acid disinfectant is characterized by consisting of a liquid A and a powder B, wherein the liquid A consists of 220 parts by weight of 50% hydrogen peroxide 160-220 parts by weight, 0.1-1 part by weight of a stabilizer, 0.01-2 parts by weight of a corrosion inhibitor, 0.5-5 parts by weight of a pH buffer and the balance of purified water; the B powder consists of 1.0 to 3.5 parts of activator, 0.01 to 0.1 part of defoamer, 0.01 to 1 part of cosolvent and 1.0 to 2.5 parts of catalyst; the above components are 1000 parts in total.
2. A solid-liquid combined peroxyacetic acid disinfectant of claim 1 wherein said stabilizer is one or more of EDTA, aminotrimethylene phosphonic acid sodium, HEDP disodium, sodium silicate, sodium benzoate, and the like.
3. The solid-liquid combined peroxyacetic acid disinfectant of claim 1, wherein the cosolvent is one or more of sodium dodecylbenzene sulfonate, sodium dodecyl sulfate and sodium dodecyl sulfate.
4. The solid-liquid combined peroxyacetic acid disinfectant as claimed in claim 1, wherein the corrosion inhibitor is one or more of sodium silicate, sodium tungstate, sodium molybdate, sodium gluconate, benzotriazole and sodium 2-hydroxyphosphonoacetate.
5. A solid-liquid combination peroxyacetic acid disinfectant of claim 1 wherein said pH buffering agent is one or more of disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium phosphate, potassium dihydrogen phosphate, sodium acetate, and the like.
6. A solid-liquid combined peroxyacetic acid disinfectant liquid according to claim 1, wherein said activator is one or more of TAED, sodium acetylsalicylate, sodium nonanoyloxybenzenesulfonate, caprolactam chloride.
7. The solid-liquid combined peroxyacetic acid disinfectant of claim 1, wherein the catalyst is one or more of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, and tetra sodium hydroxyethylidene diphosphonate.
8. The solid-liquid combined peroxyacetic acid disinfectant of claim 1, wherein the defoaming agent is one or more of block polyether, polydimethylsiloxane, silicon ether copolymer, octanol.
9. The solid-liquid combined peroxyacetic acid disinfectant as claimed in claim 1, wherein the solution A and the powder B are separately packaged, and are mixed, activated and diluted for use.
10. A process for preparing a peroxyacetic acid disinfectant liquid according to any one of the solid-liquid combination claims, comprising the steps of:
s1, weighing 50% of hydrogen peroxide raw material, stabilizer, corrosion inhibitor, pH buffer and purified water to form solution A;
s2, weighing an activating agent, a defoaming agent, a cosolvent and a catalyst to form powder B;
s3, adding the raw materials of the solution A into a mixing tank, and stirring to uniformly mix the raw materials;
adding the raw materials of the S4 and the B powder into a mixer, and mixing for 25-30 minutes at normal temperature to fully and uniformly mix the raw materials;
s5, packaging the materials of the liquid A and the powder B respectively;
s6, when in use, adding the powder B into the solution A, stirring to completely dissolve the powder B to generate enough peroxyacetic acid, and then diluting with purified water until the content of the peroxyacetic acid is more than 0.2%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115644177A (en) * | 2022-11-14 | 2023-01-31 | 利康医药科技江苏有限公司 | Neutral peroxyacetic acid disinfectant and preparation method thereof |
| CN116509895A (en) * | 2023-07-04 | 2023-08-01 | 山东利尔康医疗科技股份有限公司 | Low-concentration peracetic acid hand disinfectant and preparation method thereof |
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| CN102964285A (en) * | 2012-11-28 | 2013-03-13 | 北京红辉力上科技有限公司 | Peroxyacetic acid generator and preparation method thereof |
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| CN116509895A (en) * | 2023-07-04 | 2023-08-01 | 山东利尔康医疗科技股份有限公司 | Low-concentration peracetic acid hand disinfectant and preparation method thereof |
| CN116509895B (en) * | 2023-07-04 | 2023-09-12 | 山东利尔康医疗科技股份有限公司 | Low-concentration peracetic acid hand disinfectant and preparation method thereof |
| CN117084973A (en) * | 2023-07-04 | 2023-11-21 | 山东利尔康医疗科技股份有限公司 | Preparation and application methods of low-concentration peracetic acid hand disinfectant |
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