CN114787166A - 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 - Google Patents
噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 Download PDFInfo
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- CN114787166A CN114787166A CN202080084605.7A CN202080084605A CN114787166A CN 114787166 A CN114787166 A CN 114787166A CN 202080084605 A CN202080084605 A CN 202080084605A CN 114787166 A CN114787166 A CN 114787166A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
PCT国内申请,说明书已公开。
Claims (7)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911235372 | 2019-12-05 | ||
CN2019112353721 | 2019-12-05 | ||
PCT/CN2020/133897 WO2021110138A1 (zh) | 2019-12-05 | 2020-12-04 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN114787166A true CN114787166A (zh) | 2022-07-22 |
CN114787166B CN114787166B (zh) | 2023-09-19 |
Family
ID=76221503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202080084605.7A Active CN114787166B (zh) | 2019-12-05 | 2020-12-04 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
Country Status (6)
Country | Link |
---|---|
US (1) | US11673899B2 (zh) |
EP (1) | EP4071153B1 (zh) |
JP (1) | JP7198968B2 (zh) |
CN (1) | CN114787166B (zh) |
ES (1) | ES2960703T3 (zh) |
WO (1) | WO2021110138A1 (zh) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105358152A (zh) * | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc抑制剂和其用途 |
CN105358154A (zh) * | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc抑制剂和其用途 |
WO2017147161A1 (en) * | 2016-02-23 | 2017-08-31 | Raju Mohan | Treatment of dermatological disorders or conditions |
CN108368125A (zh) * | 2015-10-26 | 2018-08-03 | 吉利德阿波罗公司 | Acc抑制剂及其用途 |
CN108699078A (zh) * | 2016-03-02 | 2018-10-23 | 吉利德阿波罗公司 | 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法 |
CN110382503A (zh) * | 2017-03-03 | 2019-10-25 | 吉利德科学公司 | 制备acc抑制剂及其固体形式的方法 |
CN112218871B (zh) * | 2018-06-05 | 2022-10-18 | 南京明德新药研发有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类衍生物及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI701253B (zh) | 2011-11-11 | 2020-08-11 | 美商基利阿波羅有限責任公司 | Acc抑制劑及彼等之用途 |
US9765089B2 (en) * | 2013-05-10 | 2017-09-19 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
-
2020
- 2020-12-04 US US17/781,815 patent/US11673899B2/en active Active
- 2020-12-04 JP JP2022534302A patent/JP7198968B2/ja active Active
- 2020-12-04 WO PCT/CN2020/133897 patent/WO2021110138A1/zh unknown
- 2020-12-04 ES ES20896372T patent/ES2960703T3/es active Active
- 2020-12-04 CN CN202080084605.7A patent/CN114787166B/zh active Active
- 2020-12-04 EP EP20896372.8A patent/EP4071153B1/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105358152A (zh) * | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc抑制剂和其用途 |
CN105358154A (zh) * | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc抑制剂和其用途 |
CN108368125A (zh) * | 2015-10-26 | 2018-08-03 | 吉利德阿波罗公司 | Acc抑制剂及其用途 |
WO2017147161A1 (en) * | 2016-02-23 | 2017-08-31 | Raju Mohan | Treatment of dermatological disorders or conditions |
CN108699078A (zh) * | 2016-03-02 | 2018-10-23 | 吉利德阿波罗公司 | 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法 |
CN110382503A (zh) * | 2017-03-03 | 2019-10-25 | 吉利德科学公司 | 制备acc抑制剂及其固体形式的方法 |
CN112218871B (zh) * | 2018-06-05 | 2022-10-18 | 南京明德新药研发有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类衍生物及其应用 |
Also Published As
Publication number | Publication date |
---|---|
EP4071153A4 (en) | 2022-10-12 |
JP2022551769A (ja) | 2022-12-13 |
EP4071153A1 (en) | 2022-10-12 |
EP4071153B1 (en) | 2023-08-23 |
JP7198968B2 (ja) | 2023-01-04 |
CN114787166B (zh) | 2023-09-19 |
ES2960703T3 (es) | 2024-03-06 |
WO2021110138A1 (zh) | 2021-06-10 |
US20230070611A1 (en) | 2023-03-09 |
US11673899B2 (en) | 2023-06-13 |
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