CN114767755A - Traditional Chinese medicine composition for treating beriberi and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating beriberi and preparation method thereof Download PDF

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CN114767755A
CN114767755A CN202210285812.XA CN202210285812A CN114767755A CN 114767755 A CN114767755 A CN 114767755A CN 202210285812 A CN202210285812 A CN 202210285812A CN 114767755 A CN114767755 A CN 114767755A
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acetic acid
borneol
clove
ethanol
chinese medicine
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王勇伟
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Jilin Bencao Traditional Chinese Medicine Co ltd
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Jilin Bencao Traditional Chinese Medicine Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

The invention discloses a traditional Chinese medicine composition for treating beriberi and a preparation method thereof, relates to the technical field of traditional Chinese medicine compositions for treating beriberi, and particularly relates to a traditional Chinese medicine composition for treating beriberi, which comprises the following raw materials: clove, radix sophorae flavescentis, borneol, golden cypress, liquorice, acetic acid, glacial acetic acid, purified water and ethanol, wherein the weight ratios of the raw materials are as follows: 7-13g of clove, 7-13g of radix sophorae flavescentis, 5-7g of borneol, 7-13g of phellodendron, 7-13g of liquorice, 7-13g of acetic acid, 7-13g of glacial acetic acid, 1000g of ethanol and a proper amount of purified water. The clove of the invention: bacteriostasis, analgesia and antioxidation; flavescent sophora root: clearing heat, eliminating dampness, and relieving itching; borneol: clearing heat and relieving pain, and relieving swelling and pain; phellodendron bark: phellodendron bark, cortex Phellodendri clears heat and dries dampness, purges fire and detoxifies; licorice root: relieving spasm and pain; ethanol: and (5) sterilizing and disinfecting.

Description

Traditional Chinese medicine composition for treating beriberi and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine combination for treating beriberi, in particular to a traditional Chinese medicine combination for treating beriberi and a preparation method thereof.
Background
Beriberi is the most common superficial mycosis in tinea, and can be classified into blister scale type, erosion type and hyperkeratosis type according to the main clinical manifestations. Peeling, maceration, erosion, or blisters on the side of the foot occur between the toes. The patients who like to wear the air-tight shoes are frequently in need of treatment, and can cause other part infections such as tinea manuum, tinea unguium, tinea cruris and the like, but the suppository, the ointment and the spray are mainly used on the market, so that the use is inconvenient, unsanitary and long-time.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating beriberi and a preparation method thereof, and solves the problems in the background technology.
In order to achieve the purpose, the invention is realized by the following technical scheme: a traditional Chinese medicine composition for treating beriberi is composed of the following raw materials: clove, radix sophorae flavescentis, borneol, golden cypress, liquorice, acetic acid, glacial acetic acid, purified water and ethanol, wherein the weight ratios of the raw materials are as follows: 7-13g of clove, 7-13g of radix sophorae flavescentis, 5-7g of borneol, 7-13g of phellodendron, 7-13g of liquorice, 7-13g of acetic acid, 7-13g of glacial acetic acid, 1000g of ethanol and a proper amount of purified water.
A traditional Chinese medicine composition for treating dermatophytosis is prepared from the following raw materials in a preferable weight ratio: 10g of clove, 10g of sophora flavescens, 6g of borneol, 10g of phellodendron, 10g of liquorice, 10g of acetic acid, 10g of glacial acetic acid, 1000g of ethanol and a proper amount of purified water.
A preparation method of a traditional Chinese medicine composition for treating beriberi comprises the following steps:
s1, respectively weighing clove, radix sophorae flavescentis, borneol, golden cypress, liquorice, acetic acid, glacial acetic acid, purified water and ethanol according to the mass ratio, putting the clove, the radix sophorae flavescentis, the borneol, the golden cypress and the liquorice into a traditional Chinese medicine coarse crusher, and crushing into small pieces;
s2, mixing the Chinese medicinal materials uniformly, putting the mixture into an extraction tank, adding 60% ethanol into the extraction tank to a specified amount, extracting at room temperature of 20 ℃ for 7 days, and stirring once every 1 day;
s3, filtering to obtain supernatant, adding glacial acetic acid and water, and stirring once a day until the acetic acid is completely dissolved;
and S4, subpackaging according to the measurement, packaging and warehousing.
The invention provides a traditional Chinese medicine composition for treating beriberi and a preparation method thereof, and the traditional Chinese medicine composition has the following beneficial effects:
the clove of the invention: bacteriostasis, analgesia and antioxidation; flavescent sophora root: clearing heat, eliminating dampness, and relieving itching; borneol: clearing heat and relieving pain, and relieving swelling and pain; and (3) golden cypress: phellodendron bark, cortex Phellodendri clears heat and dries dampness, purges fire and detoxifies; licorice root: relieving spasm and pain; ethanol: and (5) sterilizing and disinfecting.
The invention saves time, labor and money, can prevent dead skin, old skin and cuticle and get through foot microcirculation.
Detailed Description
In the following, the technical solutions in the embodiments of the present invention are clearly and completely described, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Embodiment 1
A traditional Chinese medicine composition for treating beriberi is composed of the following raw materials: clove, radix sophorae flavescentis, borneol, golden cypress, liquorice, acetic acid, glacial acetic acid, purified water and ethanol, wherein the weight ratio of the raw materials is as follows: 7g of clove, 7g of sophora flavescens, 5g of borneol, 7g of phellodendron, 7g of liquorice, 7g of acetic acid, 7g of glacial acetic acid, 1000g of ethanol and a proper amount of purified water.
A preparation method of a traditional Chinese medicine composition for treating beriberi comprises the following steps:
s1, weighing 7g of clove, 7g of radix sophorae flavescentis, 5g of borneol, 7g of cortex phellodendri, 7g of liquorice, 7g of acetic acid, 7g of glacial acetic acid and 1000g of ethanol according to the mass ratio, and putting 7g of clove, 7g of radix sophorae flavescentis, 5g of borneol, 7g of cortex phellodendri and 7g of liquorice into a traditional Chinese medicine coarse crusher to be crushed into small pieces;
s2, mixing the Chinese medicinal materials uniformly, putting the mixture into an extraction tank, adding 1000g of ethanol 60% to a specified amount, extracting at room temperature of 20 ℃ for 7 days, and stirring once every 1 day;
s3, filtering to obtain a supernatant, adding 7g of glacial acetic acid and 7g of acetic acid, and stirring once a day until 7g of acetic acid is completely dissolved;
and S4, subpackaging according to the measurement, packaging and warehousing.
The use method comprises the following steps: spraying the medicinal preparation into disposable foot cover, wearing the disposable foot cover on the patient's foot, soaking for 30-45min, taking out, and air drying.
Example II
A traditional Chinese medicine composition for treating beriberi is composed of the following raw materials: clove, radix sophorae flavescentis, borneol, golden cypress, liquorice, acetic acid, glacial acetic acid, purified water and ethanol, wherein the weight ratios of the raw materials are as follows: 10g of clove, 10g of sophora flavescens, 5g of borneol, 10g of phellodendron, 10g of liquorice, 10g of acetic acid, 10g of glacial acetic acid, 1000g of ethanol and a proper amount of purified water.
A preparation method of a traditional Chinese medicine composition for treating beriberi comprises the following steps:
s1, respectively weighing 10g of clove, 10g of radix sophorae flavescentis, 5g of borneol, 10g of cortex phellodendri, 10g of liquorice, 10g of acetic acid, 10g of glacial acetic acid and 1000g of ethanol according to the mass ratio, and putting 10g of clove, 10g of radix sophorae flavescentis, 6g of borneol, 10g of cortex phellodendri and 10g of liquorice into a traditional Chinese medicine coarse crusher to be crushed into small pieces;
s2, mixing the Chinese medicinal materials uniformly, putting the mixture into an extraction tank, adding 1000g of ethanol 60% to a specified amount, extracting at room temperature of 20 ℃ for 7 days, and stirring once every 1 day;
s3, filtering to obtain a supernatant, adding 10g of glacial acetic acid and 10g of acetic acid into the supernatant, and stirring once a day until 10g of acetic acid is completely dissolved;
and S4, subpackaging according to the measurement, packaging and warehousing.
The application method comprises the following steps: spraying the medicinal preparation into disposable foot cover, wearing the disposable foot cover on the patient's foot, soaking for 30-45min, taking out, and air drying.
Example three
A traditional Chinese medicine composition for treating beriberi is composed of the following raw materials: clove, radix sophorae flavescentis, borneol, golden cypress, liquorice, acetic acid, glacial acetic acid, purified water and ethanol, wherein the weight ratio of the raw materials is as follows: 13g of clove, 13g of sophora flavescens, 7g of borneol, 13g of phellodendron, 13g of liquorice, 13g of acetic acid, 13g of glacial acetic acid, 1000g of ethanol and a proper amount of purified water.
A preparation method of a traditional Chinese medicine composition for treating beriberi comprises the following steps:
s1, respectively weighing 13g of clove, 13g of radix sophorae flavescentis, 7g of borneol, 13g of cortex phellodendri, 13g of liquorice, 13g of acetic acid, 13g of glacial acetic acid and 1000g of ethanol according to the mass ratio, and putting 13g of clove, 13g of radix sophorae flavescentis, 5g of borneol, 13g of cortex phellodendri and 13g of liquorice into a traditional Chinese medicine coarse crusher to be crushed into small pieces;
s2, mixing the Chinese medicinal materials uniformly, putting the mixture into an extraction tank, adding 1000g of ethanol 60% to a specified amount, extracting at room temperature of 20 ℃ for 7 days, and stirring once every 1 day;
s3, filtering to obtain a supernatant, adding 13g of glacial acetic acid and 13g of acetic acid into the supernatant, and stirring the mixture once a day until 13g of acetic acid is completely dissolved;
and S4, subpackaging according to the measurement, packaging and warehousing.
The application method comprises the following steps: spraying the medicinal preparation into disposable foot cover, wearing the disposable foot cover on the patient's foot, soaking for 30-45min, taking out, and air drying.
By combining the above embodiments, the present invention is applicable to the following diseases:
tinea manuum, tinea pedis, foot odor, split heel, sweaty foot, callosity of sole skin, and poor blood circulation of the foot of the elderly;
the formula has the following effects:
clove: bacteriostasis, analgesia and antioxidation;
flavescent sophora root: clearing heat, eliminating dampness, and relieving itching;
borneol: clearing heat and relieving pain, and relieving swelling and pain;
phellodendron bark: phellodendron bark, cortex Phellodendri clears heat and dries dampness, purges fire and detoxifies;
licorice root: relieving spasm and pain;
ethanol: and (5) sterilizing and disinfecting.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered as the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.

Claims (3)

1. A traditional Chinese medicine composition for treating beriberi is composed of the following raw materials: clove, radix sophorae flavescentis, borneol, golden cypress, liquorice, acetic acid, glacial acetic acid, purified water and ethanol, wherein the weight ratio of the raw materials is as follows: 7-13g of clove, 7-13g of sophora flavescens, 5-7g of borneol, 7-13g of phellodendron, 7-13g of liquorice, 7-13g of acetic acid, 7-13g of glacial acetic acid, 1000g of ethanol and a proper amount of purified water.
2. The Chinese medicinal composition for treating beriberi as claimed in claim 1, wherein the preferred weight ratios of the above raw materials are as follows: 10g of clove, 10g of sophora flavescens, 6g of borneol, 10g of phellodendron, 10g of liquorice, 10g of acetic acid, 10g of glacial acetic acid, 1000g of ethanol and a proper amount of purified water.
3. The preparation method of the traditional Chinese medicine composition for treating beriberi as claimed in claims 1-2, comprising the following steps:
s1, respectively weighing clove, radix sophorae flavescentis, borneol, golden cypress, liquorice, acetic acid, glacial acetic acid, purified water and ethanol according to the mass ratio, putting the clove, the radix sophorae flavescentis, the borneol, the golden cypress and the liquorice into a traditional Chinese medicine coarse crusher, and crushing into small pieces;
s2, mixing the Chinese medicinal materials uniformly, putting the mixture into an extraction tank, adding 60% ethanol into the extraction tank to a specified amount, extracting at room temperature of 20 ℃ for 7 days, and stirring once every 1 day;
s3, filtering to obtain supernatant, adding glacial acetic acid and water, and stirring once a day until the acetic acid is completely dissolved;
and S4, subpackaging according to the measurement, packaging and warehousing.
CN202210285812.XA 2022-03-23 2022-03-23 Traditional Chinese medicine composition for treating beriberi and preparation method thereof Pending CN114767755A (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202961238U (en) * 2012-11-25 2013-06-05 曾庆江 Traditional Chinese medicine liquor soaked toe socks for fundamentally treating barbiers
CN104126987A (en) * 2014-08-08 2014-11-05 王应武 Comfortable flax shoe pad capable of treating dermatophytosis
CN104147197A (en) * 2014-08-04 2014-11-19 济南康众医药科技开发有限公司 Medicine for treating tinea pedis and preparation method thereof
CN105267900A (en) * 2014-06-24 2016-01-27 张稀杰 Preparation method of traditional Chinese medicine for treating stubborn tinea pedis
CN106619946A (en) * 2015-10-29 2017-05-10 李家涛 Traditional Chinese medicine formula for treating tinea pedis
CN107596225A (en) * 2017-10-10 2018-01-19 袁子钧 A kind of tinea pedis soak and preparation method
CN107773666A (en) * 2016-08-25 2018-03-09 赖婷婷 For treating the Chinese medicine composition of tinea pedis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202961238U (en) * 2012-11-25 2013-06-05 曾庆江 Traditional Chinese medicine liquor soaked toe socks for fundamentally treating barbiers
CN105267900A (en) * 2014-06-24 2016-01-27 张稀杰 Preparation method of traditional Chinese medicine for treating stubborn tinea pedis
CN104147197A (en) * 2014-08-04 2014-11-19 济南康众医药科技开发有限公司 Medicine for treating tinea pedis and preparation method thereof
CN104126987A (en) * 2014-08-08 2014-11-05 王应武 Comfortable flax shoe pad capable of treating dermatophytosis
CN106619946A (en) * 2015-10-29 2017-05-10 李家涛 Traditional Chinese medicine formula for treating tinea pedis
CN107773666A (en) * 2016-08-25 2018-03-09 赖婷婷 For treating the Chinese medicine composition of tinea pedis
CN107596225A (en) * 2017-10-10 2018-01-19 袁子钧 A kind of tinea pedis soak and preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
杜立平: "苦参脚气散治疗脚湿气", 《新中医》 *
赵丽霞等: "苦黄软膏的药效学研究", 《中国医药学报》 *

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