CN114617778A - Natural liquid crystal structure composition and preparation method and application thereof - Google Patents
Natural liquid crystal structure composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN114617778A CN114617778A CN202111104611.7A CN202111104611A CN114617778A CN 114617778 A CN114617778 A CN 114617778A CN 202111104611 A CN202111104611 A CN 202111104611A CN 114617778 A CN114617778 A CN 114617778A
- Authority
- CN
- China
- Prior art keywords
- liquid crystal
- phase
- crystal structure
- natural liquid
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004973 liquid crystal related substance Substances 0.000 title claims abstract description 48
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 33
- 239000002994 raw material Substances 0.000 claims abstract description 24
- 239000003906 humectant Substances 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 16
- 229920000223 polyglycerol Polymers 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 8
- 230000001804 emulsifying effect Effects 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000007127 saponification reaction Methods 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 125000005456 glyceride group Chemical group 0.000 claims description 5
- 239000006210 lotion Substances 0.000 claims description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 4
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims description 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 4
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 229960005150 glycerol Drugs 0.000 claims description 4
- 229960003390 magnesium sulfate Drugs 0.000 claims description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 4
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 4
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims description 4
- 229960005323 phenoxyethanol Drugs 0.000 claims description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 239000011703 D-panthenol Substances 0.000 claims description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 2
- 235000004866 D-panthenol Nutrition 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 229960003949 dexpanthenol Drugs 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 2
- 229940051250 hexylene glycol Drugs 0.000 claims description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 2
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 2
- 229960004063 propylene glycol Drugs 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940032094 squalane Drugs 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 claims description 2
- 229940117972 triolein Drugs 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 11
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 9
- 240000002791 Brassica napus Species 0.000 description 9
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 9
- 229940055577 oleyl alcohol Drugs 0.000 description 9
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 9
- 230000003020 moisturizing effect Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 239000008269 hand cream Substances 0.000 description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- -1 polydimethylsiloxane Polymers 0.000 description 4
- 229940094541 polyglycerin-10 Drugs 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 3
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 3
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 2
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 2
- 229940070765 laurate Drugs 0.000 description 2
- 229940049964 oleate Drugs 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 229940099549 polyglycerin-3 Drugs 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229940080352 sodium stearoyl lactylate Drugs 0.000 description 2
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 description 2
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- PBWGCNFJKNQDGV-UHFFFAOYSA-N 6-phenylimidazo[2,1-b][1,3]thiazol-5-amine Chemical compound N1=C2SC=CN2C(N)=C1C1=CC=CC=C1 PBWGCNFJKNQDGV-UHFFFAOYSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- GWFGDXZQZYMSMJ-UHFFFAOYSA-N Octadecansaeure-heptadecylester Natural products CCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC GWFGDXZQZYMSMJ-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229940090958 behenyl behenate Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- GAQPWOABOQGPKA-UHFFFAOYSA-N octadecyl docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCC GAQPWOABOQGPKA-UHFFFAOYSA-N 0.000 description 1
- NKBWPOSQERPBFI-UHFFFAOYSA-N octadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC NKBWPOSQERPBFI-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940045898 sodium stearoyl glutamate Drugs 0.000 description 1
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 description 1
- LWBVAHQZGAKXPU-BOXHHOBZSA-M sodium;(4s)-4-amino-5-octadecoxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOC(=O)[C@@H](N)CCC([O-])=O LWBVAHQZGAKXPU-BOXHHOBZSA-M 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of A61K8/9789, in particular to a natural liquid crystal structure composition and a preparation method and application thereof, wherein the natural liquid crystal structure composition comprises the following raw materials in parts by weight: 5-10 parts of phase A, 8-15 parts of phase B and 70-100 parts of phase C; the preparation raw materials of the phase A at least comprise: a first emulsifier, a skin care agent, a second emulsifier; the first emulsifier is a polyglycerol derivative, and the average polymerization degree of the polyglycerol derivative is 2-10; the preparation raw materials of the B phase at least comprise: a moistening agent; the preparation raw materials of the phase C at least comprise: humectant, bacteriostatic agent, pH regulator and water. The composition has a natural liquid crystal structure, is stable in liquid crystal structure, is not interfered by polar or non-polar surfactants, temperature and liquid level changes, and has good high temperature resistance and low temperature resistance.
Description
Technical Field
The invention relates to the field of A61K8/9789, in particular to a natural liquid crystal structure composition and a preparation method and application thereof.
Background
The liquid crystal structure has good fluidity and film forming property, so that the liquid crystal structure is widely used in an emulsification system of cosmetics and has various effects of good moisturizing performance, enhancement of active ingredient permeation, repair of skin barrier layers and the like. However, since the formation of the liquid crystal structure is influenced by various factors, such as the polarity of the oil phase of the emulsion, the high molecular weight polysaccharide in the water phase, the polymer, and the stability at high and low temperatures, it is a very difficult task to formulate a stable liquid crystal system, and the influence of various factors needs to be considered at the same time.
CN110974742A discloses a moisturizing and repairing hand cream with a liquid crystal structure and a preparation method thereof, which has moisturizing and repairing effects, but has poor skin permeability, and is easy to rub mud on the surface and not to absorb the mud.
CN111297699A discloses a moisturizing body lotion with a good liquid crystal structure and a preparation method thereof, wherein polymers such as polyglyceryl ether are adopted to endow the moisturizing property and the stability of the composition, however, the introduction of the polymers brings instability of the liquid crystal structure.
Aiming at the problems in the prior art, the composition disclosed by the invention can form a stable liquid crystal structure under the conditions of different types of grease, polymers and polysaccharides and even high electrolyte content, so that the development difficulty of a liquid crystal emulsification system is greatly simplified.
Disclosure of Invention
The invention provides a natural liquid crystal structure composition, which is prepared from the following raw materials in parts by weight: 5-10 parts of phase A, 8-15 parts of phase B and 70-100 parts of phase C;
the preparation raw materials of the phase A at least comprise: a first emulsifier, a skin care agent, a second emulsifier; the first emulsifier is a polyglycerol derivative, and the average polymerization degree of the polyglycerol derivative is 2-10;
the preparation raw materials of the phase B at least comprise: a humectant;
the preparation raw materials of the phase C at least comprise: humectant, bacteriostatic agent, pH regulator and water.
As a preferred embodiment, the weight ratio of the first emulsifier to the skin care agent to the second emulsifier is (1-2): (2-6): (1.8-3).
As a preferred embodiment, the saponification value of the polyglycerol derivative is 100-170 mgKOH/g.
The saponification number refers to the number of milligrams of potassium hydroxide consumed by the alkaline hydrolysis of 1g of oil and fat, and indirectly represents the relative molecular mass of the polyglycerol derivative. The applicant found that when the saponification value of the polyglycerol derivative is 100-170mgKOH/g, the prepared composition has good refreshing and moisturizing effects, is not greasy, and has stable liquid crystal structure, presumably because the appropriate relative molecular mass can achieve the effects of partial skin infiltration and partial skin surface remaining as a film.
Preferably, the polyglycerol derivative includes at least one of a polyglycerol-2 derivative, a polyglycerol-3 derivative, a polyglycerol-6 derivative and a polyglycerol-10 derivative.
Preferably, the polyglycerin derivative includes at least one of polyglycerin-2 diisostearate, polyglycerin-2 triisostearate, polyglycerin-2 oleate, polyglycerin-2 dipolyhydroxystearate, polyglycerin-3 diisostearate, polyglycerin-3 methylglucdistearate, polyglycerin-6 didecanoate, polyglycerin-6 octanoate, polyglycerin-6 laurate, polyglycerin-6 octastearate, polyglycerin-10 pentastearate, polyglycerin-10 myristostearate, polyglycerin-10 oleate, and polyglycerin-10 laurate.
In order to achieve better water-oil balance effect, it is further preferable that the polyglycerol derivative is polyglycerol-10 pentastearate, the saponification value is 140-170mgKOH/g, the HLB value is 6-8, and the polyglycerol derivative is purchased from Wuhanxin Jiali Biotechnology Co., Ltd.
In a preferred embodiment, the skin-care agent has 14 to 22 carbon atoms.
Preferably, the skin care agent comprises at least one of hydrogenated rapeseed oleyl alcohol, hydrogenated castor oil, stearyl stearate, stearyl behenate and behenyl behenate.
Further preferably, the skin care agent is hydrogenated rapeseed oleyl alcohol.
The applicant has found that the stability of the liquid crystal structure of the composition is greatly improved when hydrogenated rapeseed oleyl alcohol is added, and the original liquid crystal structure can be stably kept when the hydrogenated rapeseed oleyl alcohol is faced with emulsifiers with different polarities and non-polarities. Hydrogenated rapeseed oleyl alcohol is a natural fatty alcohol with the carbon number between 14 and 22, and the applicant speculates that the compounding of carbon chains with different lengths and the winding of the carbon chains in three-dimensional space greatly enhance the three-dimensional stability of a liquid crystal structure, and the hydrogenated rapeseed oleyl alcohol can also show certain shrinkage and expansion stress when facing oils with different polarities so as to strengthen the stability of the structure of the hydrogenated rapeseed oleyl alcohol.
As a preferred embodiment, the relative molecular mass of the second emulsifier is 300-900.
Preferably, the second emulsifier comprises a glyceride derivative.
Preferably, the glyceride derivative includes at least one of glyceryl monooleate, glyceryl monostearate, glyceryl trioleate and glyceryl tristearate.
In order to enhance the stability of the liquid crystal structure at different liquid levels, it is further preferred that the glyceride derivative is glycerol monooleate.
As a preferred embodiment, the second emulsifier further comprises sodium stearoyl glutamate and/or sodium stearoyl lactylate.
The applicant finds that when anionic emulsifiers with different gradients and relative molecular masses are matched with each other, the stability of the liquid crystal structure at different interfaces and the hydrophilic-lipophilic balance at different temperatures can be remarkably improved, and the application range of the composition is greatly expanded.
The present invention is not particularly limited to the humectant, which may be selected from at least one of polydimethylsiloxane, caprylic/capric triglyceride, and isohexadecane, but is not limited thereto.
As a preferred embodiment, the humectant comprises at least one of glycerin, propylene glycol, sodium hyaluronate, xanthan gum, carbomer, trehalose, D-panthenol, squalane.
In a preferred embodiment, the bacteriostatic agent comprises at least one of magnesium sulfate, phenoxyethanol, ethylhexylglycerin, caprylyl glycol, hexylene glycol, paraben, and sorbic acid.
The present invention is not particularly limited to the pH adjuster, which may be at least one selected from the group consisting of disodium EDTA, tetrasodium EDTA, citric acid, and sodium citrate.
As a preferred embodiment, the weight ratio of the humectant, the bacteriostatic agent, the pH regulator and the water is (7-9): (0.8-1.3): (0.05-0.2): (70-90).
The second aspect of the present invention provides a method for preparing a natural liquid crystal structure composition, comprising the steps of: (1) adding the preparation raw materials of the phase A and the phase B into an oil phase pot, stirring and heating to prepare a premix; (2) adding water into an emulsifying pot, adding the premixed humectant into the emulsifying pot, heating, adding the premix, starting homogenizing, cooling, adding the bacteriostatic agent and the pH regulator, stirring uniformly, and discharging.
The third aspect of the invention provides an application of the natural liquid crystal structure composition in skin care emulsion, skin care essence, skin care water, skin care mask liquid, skin care cream, skin care eye cream, hand cream, skin care body lotion, skin care spray, sun cream, sun spray and skin care sleeping mask.
Compared with the prior art, the invention has the following beneficial effects:
1. the composition has a natural liquid crystal structure, is stable in liquid crystal structure, is not interfered by polar or non-polar surfactants, temperature and liquid level change, and has good high temperature resistance and low temperature resistance.
2. The composition disclosed by the invention is good in moisturizing effect, high in water replenishing rate, better in long-acting moisturizing effect and fresh and non-greasy in use feeling through human body tests.
3. The composition has wide application area and can be widely added into various skin care products.
Detailed Description
Example 1
In a first aspect of this embodiment, a natural liquid crystal structure composition is provided, which comprises the following raw materials in parts by weight: 7.7 parts of phase A, 10 parts of phase B and 82.3 parts of phase C;
the preparation raw materials of the phase A comprise: a first emulsifier, a skin care agent, a second emulsifier;
the preparation raw materials of the phase B comprise: a humectant;
the preparation raw materials of the phase C comprise: humectant, bacteriostatic agent, pH regulator and water.
The first emulsifier is polyglycerol-10 pentastearate, the saponification value is 140-170mgKOH/g, the HLB value is 6-8, and the emulsifier is purchased from Wuhanxin Jiali biological science and technology Co.
The skin care agent is hydrogenated rapeseed oleyl alcohol, purchased from Beijing lingbao technologies, Inc.
The second emulsifier glyceryl monooleate and sodium stearyl glutamate are compounded according to the weight ratio of 1: 0.1.
The weight ratio of the first emulsifier to the skin care agent to the second emulsifier is 1.5: 4: 2.2
The moistening agent is compounded by polydimethylsiloxane and caprylic capric triglyceride in a weight ratio of 1: 4.
The humectant is compounded by xanthan gum, glycerin and sodium hyaluronate in a weight ratio of 0.5:8: 0.1.
The bacteriostatic agent is prepared by compounding magnesium sulfate, phenoxyethanol and ethylhexylglycerin according to the weight ratio of 3:8: 1.
The pH regulator is EDTA disodium.
The weight ratio of the humectant to the bacteriostatic agent to the pH regulator to the water is 8.6: 1.2: 0.1: 72.4.
in a second aspect, this embodiment provides a method for preparing a natural liquid crystal composition, comprising the steps of: (1) adding the preparation raw materials of the phase A and the phase B into an oil phase pot, stirring and heating to 75 ℃ to prepare a premix; (2) adding water into an emulsifying pot, adding the premixed humectant into the emulsifying pot, heating to 75 ℃, adding the premix, starting homogenizing at 3000rpm for 10 minutes, cooling to 40 ℃, adding the bacteriostatic agent and the pH regulator, uniformly stirring, and discharging.
In a third aspect, the present invention provides a natural liquid crystal structure composition for use in a hand cream.
Example 2
In a first aspect of this embodiment, a natural liquid crystal structure composition is provided, which comprises the following raw materials in parts by weight: 7.5 parts of phase A, 10 parts of phase B and 82.5 parts of phase C;
the preparation raw materials of the phase A comprise: a first emulsifier, a skin care agent, a second emulsifier;
the preparation raw materials of the B phase comprise: a humectant;
the preparation raw materials of the C phase comprise: humectant, bacteriostatic agent, pH regulator and water.
The first emulsifier is polyglycerol-10 pentastearate, the saponification value is 140-170mgKOH/g, the HLB value is 6-8, and the emulsifier is purchased from Wuhanxin Jiali biological science and technology Co.
The skin care agent is hydrogenated rapeseed oleyl alcohol.
The second emulsifier is composed of glyceryl monooleate and sodium stearoyl lactylate in a weight ratio of 4: 1.
The weight ratio of the first emulsifier to the skin care agent to the second emulsifier is 1: 4: 2.5.
the moistening agent is compounded by polydimethylsiloxane and caprylic capric triglyceride in a weight ratio of 1: 4.
The polydimethylsiloxane was purchased from dow chemistry.
The humectant is compounded by xanthan gum, glycerin and sodium hyaluronate in a weight ratio of 0.5:8: 0.1.
The bacteriostatic agent is prepared by compounding magnesium sulfate, phenoxyethanol and ethylhexylglycerin according to the weight ratio of 3:8: 1.
The pH regulator is EDTA disodium.
The weight ratio of the humectant to the bacteriostatic agent to the pH regulator to the water is 8.6: 1.2: 0.1: 72.4.
in a second aspect, this embodiment provides a method for preparing a natural liquid crystal composition, comprising the steps of: (1) adding the preparation raw materials of the phase A and the phase B into an oil phase pot, stirring and heating to 75 ℃ to prepare a premix; (2) adding water into an emulsifying pot, adding the premixed humectant into the emulsifying pot, heating to 75 ℃, adding the premix, starting homogenizing at 3000rpm for 10 minutes, cooling to 40 ℃, adding the bacteriostatic agent and the pH regulator, uniformly stirring, and discharging.
In a third aspect, the present invention provides a natural liquid crystal structure composition for use in a hand cream.
Comparative example 1
This comparative example provides, in a first aspect, a natural liquid crystal structured composition, as in example 1, except that the skin care agent is cetearyl alcohol.
In a second aspect, this comparative example provides a process for preparing a natural liquid crystal structured composition, the specific embodiment of which is the same as in example 1.
In a third aspect of this comparative example, there is provided the use of a natural liquid crystal structured composition in a hand cream.
Comparative example 2
This comparative example provides in a first aspect a natural liquid crystalline structured composition, according to the same embodiment as example 1, except that the second emulsifier is glycerol monooleate.
The second aspect of this comparative example provides a method for preparing a natural liquid crystal structure composition, the detailed embodiment is the same as example 1.
In a third aspect of the present comparative example, there is provided the use of a natural liquid crystal structure composition in a hand cream.
Performance testing
The stability test method comprises the following steps: the same mass of the compositions of the examples and comparative examples were placed in an environment of-18 deg.C, 5 deg.C, 48 deg.C for 30 days and 8 cycles of 24 hours each at-8 deg.C, -40 deg.C, respectively, and the appearance of the compositions was observed.
Moisture retention test method:
1. 30 subjects were selected and randomized into two groups, one group of 15 tested for the example 1 formulation and one group of 15 tested for the comparative example 1 formulation.
2. Before the test, the testee needs to clean the inner side of the front arm with water, wipe the inner side clean with dry facial tissue, sit still for 30min in a room with the relative humidity of 50% at 25 ℃, cannot drink water and keep relaxed.
3. After cleaning and drying, the inner side of the front arm is divided into 3 test areas on average, and the moisture basic value W1 of the skin of the three test areas is recorded by a skin tester respectively. The skin tester is purchased from Beijing Hongmai commercial LLC of Derma-Expert MC 760.
4. The composition of the example and the comparative example, namely the size of soybean, is uniformly and clockwise painted on three test areas in a circle mode, the moisture value W2 of the skin of the three test areas is recorded at 30 minutes, 2 hours and 4 hours after the painting, and the water supplement rate is (W2-W1)/W1 x 100%.
Claims (10)
1. The natural liquid crystal structure composition is characterized by comprising the following preparation raw materials in parts by weight: 5-10 parts of phase A, 8-15 parts of phase B and 70-100 parts of phase C;
the preparation raw materials of the phase A at least comprise: a first emulsifier, a skin care agent, a second emulsifier; the first emulsifier is a polyglycerol derivative, and the average polymerization degree of the polyglycerol derivative is 2-10;
the preparation raw materials of the B phase at least comprise: a moistening agent;
the preparation raw materials of the phase C at least comprise: humectant, bacteriostatic agent, pH regulator and water.
2. The natural liquid crystal composition as defined in claim 1, wherein the saponification value of the polyglycerol derivative is 100-170 mgKOH/g.
3. The natural liquid crystal structure composition according to any one of claims 1 to 2, wherein the skin-care agent has 14 to 22 carbon atoms.
4. The natural liquid crystal structure composition as described in any one of claims 1 to 3, wherein the relative molecular mass of the second emulsifier is 300-900.
5. A natural liquid crystal structure composition according to any of claims 1 to 4, wherein the second emulsifier comprises a glyceride derivative.
6. The natural liquid crystal structured composition of claim 5, wherein said glyceride derivative comprises at least one of glyceryl monooleate, glyceryl monostearate, glyceryl trioleate, and glyceryl tristearate.
7. The natural liquid crystal structured composition of any one of claims 1 to 6, wherein the humectant comprises at least one of glycerin, propylene glycol, sodium hyaluronate, xanthan gum, carbomer, trehalose, D-panthenol, and squalane.
8. The natural liquid crystal structure composition of any one of claims 1-7, wherein the bacteriostatic agent comprises at least one of magnesium sulfate, phenoxyethanol, ethylhexylglycerin, caprylyl glycol, hexylene glycol, paraben, sorbic acid.
9. A method for preparing a natural liquid crystal structuring composition according to any one of claims 1 to 8, comprising the steps of: (1) adding the preparation raw materials of the phase A and the phase B into an oil phase pot, stirring and heating to prepare a premix; (2) adding water into an emulsifying pot, adding the premixed humectant into the emulsifying pot, heating, adding the premix, starting homogenizing, cooling, adding the bacteriostatic agent and the pH regulator, stirring uniformly, and discharging.
10. Use of a natural liquid crystal structure composition according to any one of claims 1 to 8 in skin care lotions, skin care essences, skin lotions, skin mask liquids, skin care creams, skin care eye creams, hand creams, skin care body lotions, skin care sprays, sun creams, sun sprays, skin care sleep masks.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115154371A (en) * | 2022-07-13 | 2022-10-11 | 广东柏俐臣生物科技有限公司 | Emulsion type moisturizing and relieving spray water and preparation method thereof |
| CN115887304A (en) * | 2022-12-20 | 2023-04-04 | 科乐美(广州)生物科技有限公司 | Emulsifier composition, skin cream containing emulsifier composition and preparation method of skin cream |
| CN117257660A (en) * | 2023-09-12 | 2023-12-22 | 广州海龟爸爸生物科技有限公司 | Powder slurry capable of enhancing sun-proof performance and improving makeup-holding effect, and preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1711070A (en) * | 2002-11-15 | 2005-12-21 | 狮王株式会社 | Shampoo composition |
| JP2011213651A (en) * | 2010-03-31 | 2011-10-27 | Nippon Menaade Keshohin Kk | Emulsion cosmetic |
| CN103565662A (en) * | 2013-10-31 | 2014-02-12 | 天津郁美净集团有限公司 | Water-resistant liquid crystal cosmetic |
| CN107072898A (en) * | 2014-06-25 | 2017-08-18 | 莱雅公司 | In nanoemulsions or microemulsion form or the composition with layer structure |
| CN110368323A (en) * | 2019-08-05 | 2019-10-25 | 广州市玉鑫化妆品有限公司 | A kind of composite skin care product and its preparation method and application containing liquid crystal emulsifier |
| CN112135667A (en) * | 2018-11-30 | 2020-12-25 | 高级醇工业株式会社 | Novel complex and emulsified composition |
| CN113509395A (en) * | 2021-07-08 | 2021-10-19 | 广州科斯曼生物科技有限公司 | Liquid crystal emulsifier with anti-allergy and relieving effects and bionic sebum membrane design, and preparation method and application thereof |
-
2021
- 2021-09-22 CN CN202111104611.7A patent/CN114617778B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1711070A (en) * | 2002-11-15 | 2005-12-21 | 狮王株式会社 | Shampoo composition |
| JP2011213651A (en) * | 2010-03-31 | 2011-10-27 | Nippon Menaade Keshohin Kk | Emulsion cosmetic |
| CN103565662A (en) * | 2013-10-31 | 2014-02-12 | 天津郁美净集团有限公司 | Water-resistant liquid crystal cosmetic |
| CN107072898A (en) * | 2014-06-25 | 2017-08-18 | 莱雅公司 | In nanoemulsions or microemulsion form or the composition with layer structure |
| CN112135667A (en) * | 2018-11-30 | 2020-12-25 | 高级醇工业株式会社 | Novel complex and emulsified composition |
| CN110368323A (en) * | 2019-08-05 | 2019-10-25 | 广州市玉鑫化妆品有限公司 | A kind of composite skin care product and its preparation method and application containing liquid crystal emulsifier |
| CN113509395A (en) * | 2021-07-08 | 2021-10-19 | 广州科斯曼生物科技有限公司 | Liquid crystal emulsifier with anti-allergy and relieving effects and bionic sebum membrane design, and preparation method and application thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115154371A (en) * | 2022-07-13 | 2022-10-11 | 广东柏俐臣生物科技有限公司 | Emulsion type moisturizing and relieving spray water and preparation method thereof |
| CN115887304A (en) * | 2022-12-20 | 2023-04-04 | 科乐美(广州)生物科技有限公司 | Emulsifier composition, skin cream containing emulsifier composition and preparation method of skin cream |
| CN115887304B (en) * | 2022-12-20 | 2023-10-03 | 科乐美(广州)生物科技有限公司 | Emulsifier composition, skin care cream containing same and preparation method of skin care cream |
| CN117257660A (en) * | 2023-09-12 | 2023-12-22 | 广州海龟爸爸生物科技有限公司 | Powder slurry capable of enhancing sun-proof performance and improving makeup-holding effect, and preparation method and application thereof |
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