CN114599334A - Stable low pH personal care compositions and methods therefor - Google Patents
Stable low pH personal care compositions and methods therefor Download PDFInfo
- Publication number
- CN114599334A CN114599334A CN201980101674.1A CN201980101674A CN114599334A CN 114599334 A CN114599334 A CN 114599334A CN 201980101674 A CN201980101674 A CN 201980101674A CN 114599334 A CN114599334 A CN 114599334A
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- Prior art keywords
- personal care
- care composition
- equal
- amount
- alcohol
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Classifications
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- A61Q19/00—Preparations for care of the skin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
Abstract
Personal care compositions and methods for making the same are disclosed. The personal care composition may comprise an emulsifying system, one or more emollients, and one or more humectants. The method for preparing the personal care composition may comprise contacting the emulsifying system, the one or more emollients, and the one or more humectants with one another.
Description
Background
Personal care compositions such as emulsions may typically contain one or more conventional and/or non-natural ingredients that provide skin conditioning, anti-foaming, and skin protection. Recent consumer awareness of non-natural ingredients has pushed compositions to more natural formulations containing naturally derived ingredients. Accordingly, efforts have been directed to reducing or eliminating non-natural ingredients from personal care compositions to provide improved consumer perception. However, removal or replacement of non-natural ingredients has proven particularly difficult for low pH formulations. For example, the removal or replacement of non-natural ingredients in low pH (e.g., pH of about 4 to about 5) formulations often results in products that exhibit instability or phase separation during aging studies.
Accordingly, there is a need for improved low pH personal care compositions and methods for making the same.
Disclosure of Invention
This summary is intended only to introduce a simplified summary of some aspects of one or more embodiments of the disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, is not intended to identify key or critical elements of the teachings, nor is it intended to be used to delineate the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in a simplified form as a prelude to the more detailed description that is presented later.
The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing a personal care composition comprising an emulsification system, one or more emollients, and one or more humectants.
In at least one embodiment, the emulsifying system may comprise a cationic surfactant. The cationic surfactant may comprise an esterquat. The esterquat may comprise one or more of behenylethyldimethylammonium chloride, dipalmitoylethyldimethylammonium chloride, distearoylethyldimethylammonium chloride, ditalloyl pg-dimethylammonium chloride, dipalmitoylethylmethylammonium sulfate, distearoylethylhydroxyethylmethylammonium sulfate, or combinations thereof. The cationic surfactant may be dipalmitoylethyldimethylammonium chloride.
In at least one embodiment, the emulsification system may comprise one or more nonionic surfactants. The one or more nonionic surfactants can comprise cetearyl alcohol, ceteareth-20, cetyl alcohol, stearyl alcohol, or a combination thereof. Cetearyl alcohol and ceteareth-20 may be present in an amount from about 3% to about 5% by weight, based on the total weight of the personal care composition. Cetearyl alcohol and ceteareth-20 may also be present in an amount of about 4% by weight, based on the total weight of the personal care composition. Cetearyl alcohol and ceteareth-20 may further be present in an amount of greater than or equal to about 5 wt%, based on the total weight of the personal care composition. In at least one embodiment, the cetyl alcohol is present in an amount greater than or equal to about 3 wt%, optionally about 3.5 wt%, based on the total weight of the personal care composition.
In at least one embodiment, the one or more emollients may comprise isopropyl palmitate. The isopropyl palmitate may be present in an amount greater than or equal to about 1.5 wt% based on the total weight of the personal care composition.
In at least one embodiment, the isopropyl palmitate may be present in an amount of greater than or equal to about 4 wt.%, based on the total weight of the personal care composition; cetyl alcohol and stearyl alcohol may be present in an amount of greater than or equal to about 6.5 wt%, based on the total weight of the personal care composition; and the nonionic surfactant can comprise cetearyl alcohol and ceteareth-20 in an amount of greater than or equal to about 4 wt%, based on the total weight of the personal care composition.
In at least one embodiment, the one or more humectants can comprise glycerin, caprylyl glycol, or a combination thereof.
In at least one embodiment, the personal care composition is substantially free of silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof.
In at least one embodiment, the personal care composition is substantially free of silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, or any combination thereof.
In at least one embodiment, the personal care composition further comprises one or more acids. The one or more acids may comprise lactic acid.
In at least one embodiment, the personal care composition can have an acidic pH. For example, the pH may be from about 4 to about 6, or the pH may be from about 4 to about 5.
In at least one embodiment, the personal care composition can have a viscosity of greater than or equal to 50,000 centipoise (cP) and less than or equal to 200,000cP at 25 ℃.
In at least one embodiment, the personal care composition exhibits no phase separation after exposure to accelerated aging conditions.
The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing a method for preparing any of the personal care compositions disclosed herein. The method may comprise contacting the emulsifying system, the one or more emollients, and the one or more humectants with one another.
Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating some exemplary aspects of the disclosure, are intended for purposes of illustration only and are not intended to limit the scope of the disclosure.
Detailed Description
The following description of various exemplary aspects is merely exemplary in nature and is in no way intended to limit the disclosure, its application, or uses.
Ranges are used throughout this disclosure as shorthand for describing each and every value that is within the range. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as a rigid limitation on the scope of any embodiment or embodiments disclosed herein. Accordingly, the disclosed range should be construed as specifically disclosing all possible sub-ranges and individual numerical values within that range. Accordingly, any value within the range can be selected as the terminus of the range. For example, a description of a range such as 1 to 5 should be read as specifically disclosing sub-ranges such as 1.5 to 3, 1 to 4.5, 2 to 5, 3.1 to 5, etc., and individual numbers within that range, such as 1,2, 3, 3.2, 4, 5, etc. This applies regardless of the breadth of the range.
Unless otherwise indicated, all percentages and amounts expressed herein and elsewhere in this specification are to be understood as referring to weight percentages. The amounts given are based on the effective weight of the material.
In addition, all numerical values are "about" or "approximately" the stated value, and experimental error and variation as contemplated by one of ordinary skill in the art are contemplated. It is to be understood that all values and ranges disclosed herein are approximate values and ranges, regardless of whether "about" is used in connection therewith. It is also to be understood that, as used herein, the term "about" in conjunction with a number refers to a value that may be ± 0.01% (inclusive), ± 0.1% (inclusive), ± 0.5% (inclusive), ± 1% (inclusive), ± 2% (inclusive), ± 3% (inclusive), ± 5% (inclusive), ± 10% (inclusive), or ± 15% (inclusive) of the number. It should also be understood that when numerical ranges are disclosed herein, any number falling within the range is also specifically disclosed.
As used herein, "free of or" substantially free of a material can refer to a composition, component, or phase in which the material is present in an amount of less than 10.0 wt.%, less than 5.0 wt.%, less than 3.0 wt.%, less than 1.0 wt.%, less than 0.1 wt.%, less than 0.05 wt.%, less than 0.01 wt.%, less than 0.005 wt.%, or less than 0.0001 wt.%, based on the total weight of the composition, component, or phase.
All references cited herein are incorporated by reference in their entirety. In the event that a definition in this disclosure conflicts with a definition in a cited reference, the disclosure controls.
The present inventors have surprisingly and unexpectedly discovered that stable, low pH personal care compositions can be prepared by providing one or more primary emulsifiers (e.g., cetearyl alcohol and ceteareth-20) in an amount of from about 3% to about 5%, from about 3.5% to about 4.5%, or about 4%, cetyl alcohol and stearyl alcohol in a total amount of greater than or equal to about 4% or greater than or equal to about 5%, and cetyl alcohol in an amount of about 3.5% or greater.
The inventors have also surprisingly and unexpectedly found that stable personal care compositions having a pH of from about 4 to about 5 can be prepared when isopropyl palmitate is present in an amount of about 1.5% or at least 1.5%.
The inventors have also surprisingly and unexpectedly discovered that when isopropyl palmitate is present in the personal care composition in an amount of about 4% or greater, then a stable personal care composition having a pH of from about 4 to about 5 can be prepared by providing cetyl alcohol and stearyl alcohol in an amount of about 6.5% or greater and/or cetearyl alcohol/ceteareth-20 in an amount of about 4% or greater in total.
Composition comprising a metal oxide and a metal oxide
The compositions disclosed herein may be or comprise a stable, low pH personal care composition comprising an emulsification system comprising one or more surfactants and/or one or more emulsifiers, one or more emollients, one or more humectants, or any combination thereof. The compositions disclosed herein may be free or substantially free of silicone, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof. For example, the composition may comprise a silicone or silicone compound, and be free or substantially free of PEG. In another example, the composition can comprise PEG and be free or substantially free of silicone, silicone compounds, propylene glycol, mineral oil, petrolatum, or any combination thereof. In another example, the compositions disclosed herein can be or comprise a skin moisturizing composition, such as a low pH skin moisturizing composition or a low pH emulsion or cream, that is free or substantially free of silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof.
The personal care compositions disclosed herein may exhibit comparable, enhanced, or relatively greater stability compared to conventional personal care compositions comprising silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof. For example, the personal care compositions disclosed herein may not exhibit phase separation, a relatively stable pH, and/or a relatively stable viscosity when exposed to various aging conditions as compared to conventional personal care compositions comprising any one or more of silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof. As used herein, the term or expression "relatively stable" may refer to a characteristic or value that does not change (e.g., increase or decrease) by an amount greater than 0.5%, greater than 1%, greater than 1.5%, greater than 2%, greater than 2.5%, greater than 3%, greater than 3.5%, greater than 4%, greater than 4.5%, greater than 5%, greater than 6%, greater than 7%, greater than 8%, greater than 9%, or greater than 10% compared to the original characteristic or value. As further described herein, the personal care composition can comprise an emulsifying system, one or more emollients, one or more humectants, or any combination thereof, which are capable of or configured to provide comparable or enhanced stability to the personal care composition, as compared to conventional personal care compositions comprising any one or more of silicone, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof.
As used herein, the term or expression "personal care composition" may refer to a composition for topical application to a mammal, particularly human skin. The personal care composition may generally be a leave-on personal care composition or a rinse-off personal care composition, and may comprise any product that is applied to the human body. The personal care composition is preferably a leave-on personal care composition. The personal care composition may be in any suitable form. Illustrative forms of personal care compositions can be or include, but are not limited to, liquids, lotions, creams, foams, scrubs, gels, soap bars, skin fresheners, and the like, applied with a device or by a mask. Illustrative personal care compositions can be or include, but are not limited to, leave-on lotions and creams, emulsions, shampoos, conditioners, body washes, antiperspirants, deodorants, depilatories, lipsticks, foundations, mascaras, sunless tanning agents, sunscreens, and the like.
The personal care composition may comprise a hydrophobic phase and a hydrophilic phase that are combined, mixed, contacted, or otherwise emulsified with one another. For example, the personal care composition may be a water-in-oil emulsion comprising a hydrophilic phase dispersed or suspended in a continuous hydrophobic phase. In another example, the personal care composition may be an oil-in-water emulsion comprising a hydrophobic phase dispersed or suspended in a continuous hydrophilic phase. In a preferred embodiment, the personal care composition is an oil-in-water emulsion comprising a hydrophobic phase suspended in a continuous hydrophilic phase.
The personal care composition may have an acidic pH. For example, the personal care composition may have a pH of about 3, about 3.5, about 4, or about 4.5 to about 5, about 5.5, about 6, or about 6.5. In another example, the personal care composition can have a pH of less than 7, less than 6.5, less than 6, less than 5.5, less than 5, or less than 4.5. In a preferred embodiment, the personal care composition may have a pH of from about 4.0 to about 5.0, or from about 4.2 to about 4.8, more preferably from about 4.2 to about 4.6.
As used herein, the term or expression "absorbable" may refer to the rate at which the personal care composition is absorbed into the skin or how quickly the personal care composition will be absorbed into the skin. The personal care composition can have an absorbability score or value of greater than or equal to about 2.0, where '0' represents the lowest level (i.e., none or low) and '5' represents the highest value, as determined by a sensory panel using a standardized method and an assessment scale of 0 to 5 points. For example, the personal care composition can have an absorbency score of greater than or equal to about 2.0, greater than or equal to about 2.2, greater than or equal to about 2.4, greater than or equal to about 2.6, greater than or equal to about 2.8, greater than or equal to about 3.0, greater than or equal to about 3.2, greater than or equal to about 3.4, greater than or equal to about 3.6, greater than or equal to about 3.8, greater than or equal to about 4.0, as determined by a sensory panel. In a preferred embodiment, the personal care composition has an absorbency score of greater than or equal to about 2.7.
As used herein, the term or expression "whiteness" or "whiteness score" can refer to an amount of white color perceived as visible on the skin during application or rubbing. The personal care composition can have a whiteness score or value of less than or equal to about 3.6, as determined by a sensory panel using a standardized method and an assessment scale of 0 to 5 points, where '0' represents the lowest level (i.e., none or low) and '5' represents the highest value. For example, the personal care composition can have a whiteness score of less than or equal to about 3.6, less than or equal to about 3.4, less than or equal to about 3.2, less than or equal to about 3.0, less than or equal to about 2.8, less than or equal to about 2.6, less than or equal to about 2.4, less than or equal to about 2.2, less than or equal to about 2.0, less than or equal to about 1.8, less than or equal to about 1.6, less than or equal to about 1.5, less than or equal to about 1.4, less than or equal to about 1.3, less than or equal to about 1.2, less than or equal to about 1.1, less than or equal to about 1, as determined by the sensory panel. In a preferred embodiment, the personal care composition has a whiteness score of less than or equal to about 2.7.
As used herein, the term or expression "tackiness" or "tackiness score" may refer to the sticky feel left after the personal care composition is applied to the skin surface. The personal care composition can have an adherence score or value of less than or equal to about 3.0, as determined by a sensory panel using a standardized method and an assessment scale of 0 to 5 points, where '0' represents the lowest level (i.e., none or low) and '5' represents the highest value. For example, the personal care composition can have an adherence score of less than or equal to about 3.0, less than or equal to about 2.8, less than or equal to about 2.6, less than or equal to about 2.4, less than or equal to about 2.2, less than or equal to about 2.0, less than or equal to about 1.8, less than or equal to about 1.6, less than or equal to about 1.4, as determined by a sensory panel. In a preferred embodiment, the personal care composition has an adherence score of less than or equal to about 2.0.
As used herein, the term or expression "spreadability" or "spreadability score" may refer to how easily a personal care composition is distributed on or over the surface of the skin. The personal care composition can have a spreadability score or value of greater than or equal to about 2.0, as determined by a sensory panel using a standardized method and an assessment scale of 0 to 5 points, where '0' represents the lowest level (i.e., none or low) and '5' represents the highest value. For example, the personal care composition can have a spreadability score of greater than or equal to about 2.0, greater than or equal to about 2.2, greater than or equal to about 2.4, greater than or equal to about 2.6, greater than or equal to about 2.8, greater than or equal to about 3.0, greater than or equal to about 3.2, greater than or equal to about 3.4, greater than or equal to about 3.6, greater than or equal to about 3.8, greater than or equal to about 4.0, greater than or equal to about 4.1, greater than or equal to about 4.2, greater than or equal to about 4.3, or greater than or equal to about 4.4, as determined by a sensory panel. In a preferred embodiment, the personal care composition has a spreadability score of greater than or equal to about 3.0.
As used herein, the term or expression "greasiness" or "greasiness score" may refer to the amount of greasiness felt on the skin surface during and/or after application. The personal care composition can have a greasiness score or value of less than or equal to about 3.6, as determined by a sensory panel using a standardized method and an assessment scale of 0 to 5 points, where '0' represents the lowest level (i.e., none or low) and '5' represents the highest value. For example, the personal care composition can have a greasiness score of less than or equal to about 3.6, less than or equal to about 3.4, less than or equal to about 3.2, less than or equal to about 3.0, less than or equal to about 2.8, less than or equal to about 2.6, less than or equal to about 2.4, less than or equal to about 2.2, less than or equal to about 2.0, less than or equal to about 1.8, less than or equal to about 1.7, less than or equal to about 1.6, less than or equal to about 1.5, or less than or equal to about 1.4, as determined by the sensory panel. In a preferred embodiment, the personal care composition has a greasiness score of less than or equal to about 2.5.
The viscosity of the personal care composition can be greater than or equal to about 5,000 centipoise (cP), about 10,000cP, or about 20,000cP and/or less than or equal to about 200,000cP as measured with a T93 spindle at about 10RPM, up to about 100,000cP, or from about 100,000cP to about 200,000cP as measured with a T95 spindle at about 5RPM, as determined using a viscometer at a temperature of about 25 ℃. As used herein, "viscosity" may refer to the internal flow resistance or the ratio of shear stress to shear rate exhibited by a fluid and may be measured in poise or centipoise (cP). For example, the viscosity of the personal care composition at about 25 ℃ can be greater than or equal to about 5,000cP, greater than or equal to about 10,000cP, greater than or equal to about 20,000cP, greater than or equal to about 25,000cP, greater than or equal to about 30,000cP, greater than or equal to about 35,000cP, greater than or equal to about 40,000cP, greater than or equal to about 45,000cP, greater than or equal to about 60,000cP, greater than or equal to about 70,000cP, greater than or equal to about 100,000 cP. In another example, the viscosity of the personal care composition at about 25 ℃ can be less than or equal to about 200,000cP, less than or equal to about 150,000cP, less than or equal to about 100,000cP, less than or equal to about 95,000cP, less than or equal to about 90,000cP, less than or equal to about 85,000cP, less than or equal to about 80,000cP, less than or equal to about 75,000cP, less than or equal to about 70,000cP, less than or equal to about 65,000cP, less than or equal to about 60,000cP, or less than or equal to about 55,000 cP. In a preferred embodiment, the personal care composition has a viscosity of from about 50,000cP to about 150,000cP at about 25 ℃.
The personal care compositions disclosed herein may not exhibit any phase separation after exposure to accelerated aging conditions. The personal care compositions disclosed herein may not exhibit any phase separation after exposure of the personal care composition to one or more freeze-thaw treatments. For example, the personal care compositions disclosed herein may not exhibit any phase separation after at least or about 3 cycles/treatment of a freeze-thaw treatment between-30 ℃ and room temperature. In another example, the personal care compositions disclosed herein may not exhibit any phase separation after at least or about 3 cycles/treatment between-10 ℃ and room temperature of a freeze-thaw treatment.
The personal care compositions disclosed herein may not exhibit any phase separation after exposing the personal care composition to a temperature of about 30 ℃, about 40 ℃, or about 49 ℃ for an extended period of time. For example, the personal care compositions disclosed herein may not exhibit any phase separation after holding the personal care composition at about 49 ℃ for at least 4 weeks or more. In another example, the personal care compositions disclosed herein may not exhibit any phase separation after holding the personal care composition at about 30 ℃ for at least 4 weeks, at least 8 weeks, at least 13 weeks, or longer. In yet another example, the personal care compositions disclosed herein may not exhibit any phase separation after holding the personal care composition at about 40 ℃ for at least 4 weeks, at least 8 weeks, at least 13 weeks, or longer. It should be understood that phase separation in the personal care composition is determined visually.
In exemplary embodiments, the personal care composition may be free of any one or more of substantially no silicone, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof. For example, the personal care composition may comprise polyethylene glycol (PEG), and may be free or substantially free of silicones, silicone compounds, propylene glycol, mineral oil, and petrolatum. In another example, the personal care composition may exclude all of the following: silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, and polyethylene glycol (PEG). In yet another example, the personal care composition may comprise only one, two, three, four, or five of the following and the remainder are excluded: silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, and polyethylene glycol (PEG). Illustrative silicones or silicone compounds can be or include, but are not limited to, polysiloxane polymers such as polydimethylsiloxane, dimethiconol, cyclopentasiloxane, or any combination thereof.
In at least one embodiment, the personal care composition may comprise one or more humectants. Illustrative humectants can be or can include, but are not limited to, glycerin (e.g., vegetable refined glycerin, etc.), propylene glycol, polyethylene glycol, ascorbic acid, ascorbyl dipalmitate, acetamide MEA, octylglycol, glucose glutamate, glucuronic acid, TEA salt of lactic acid, TEA-PCA, corn syrup, fructose, glucose, glycerol, ethylene glycol, 1,2, 6-hexanetriol, sodium lactate, sodium PCA, hydrogenated starch hydrolysate, inositol, lactic acid, lactose, mannitol, PCA, PEG-10 propylene glycol, polyaminosugar condensate, pyridoxine dilaurate, hydroxystearylmethylglucamine, glucosamine, maltitol, mannitol, methyl glucose polyether-10, methyl glucose polyether-20, riboflavin, PEG-4, PEG-6, PEG-8, PEG-9, PEG-10, and mixtures thereof, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-40, glutamic acid, glyceryl polyether-7, glyceryl polyether-12, glyceryl polyether-26, saccharide isomerate, sorbitol polyether-20, sorbitol, sucrose, thioglycerol, tris (hydroxymethyl) nitromethane, tromethamine, histidine, PEG-75, PEG-135, PEG-150, PEG-200, PEG-5 pentaerythritol ether, polyglyceryl sorbitol, urea, xylitol and the like, or combinations thereof. In a preferred embodiment, the humectant may be or include, but is not limited to, glycerin, caprylyl glycol, or combinations thereof.
The one or more humectants can be present in an amount of from about 0.1 wt% to about 10 wt%, or from about 0.5 wt% to about 20 wt%, based on the total weight of the personal care composition. For example, any one or more humectants can be present in an amount of about 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 1 wt%, about 1.5 wt%, about 2 wt%, about 2.5 wt%, about 3 wt%, about 3.5 wt%, about 4 wt%, about 4.5 wt%, or about 5 wt% to about 5.5 wt%, about 6 wt%, about 6.5 wt%, about 7 wt%, about 7.5 wt%, about 8 wt%, about 8.5 wt%, about 9 wt%, about 9.5 wt%, about 10 wt%, or about 20 wt%, based on the total weight of the personal care composition. In preferred embodiments, the humectant comprises glycerin and/or caprylyl glycol in an amount of from about 1.5 to about 10 wt.%, from about 2 wt.% to about 8 wt.%, from about 3 wt.% to about 7 wt.%, or about 5 wt.%, based on the total weight of the personal care composition.
In at least one embodiment, the personal care composition may comprise one or more preservatives in an amount greater than 0 wt% and less than or equal to about 3 wt%, less than or equal to about 2.5 wt%, less than or equal to about 2 wt%, less than or equal to about 1.5 wt%, less than or equal to about 1 wt%, less than or equal to about 0.75 wt%, less than or equal to about 0.5 wt%, or less than or equal to about 0.25 wt%, based on the total weight of the personal care composition. Illustrative preservatives can include, but are not limited to: benzalkonium chloride; benzethonium chloride, 5-bromo-5-nitro-1, 3-dioxane; 2-bromo-2-nitropropane-1, 3-diol; alkyl trimethyl ammonium bromide; n- (hydroxymethyl) -N- (1, 3-dimethylol-2, 5-dioxo-4-imidazolidinyl-N- (hydroxymethyl) urea, 1-3-dimethanol-5, 5-dimethylhydantoin, formaldehyde, iodopropynyl butyl carbamate, butyl paraben, ethyl paraben, methyl paraben, propyl paraben, a 1:3 weight ratio mixture of methylisothiazolinone/methyl-chloroisothiazoline, a mixture of polyvinyl pyrrole/butyl paraben/methyl paraben/propyl paraben, 2-phenoxyethanol, trihydroxyethyl-hexahydrotriazine, methylisothiazolinone, 5-chloro-2-methyl-4-isothiazolin-3-one, 1, 2-dibromo-2, 4-dicyanobutane; 1- (3-chloroalkyl) -3,5, 7-triaza-azoniaadamantane chloride; sodium benzoate; organic acids, sorbic acid, lactic acid, citric acid, and the like, or any combination thereof.
In at least one embodiment, the one or more preservatives comprise sodium benzoate in an amount from greater than 0 wt% to less than or equal to 2 wt%, from greater than 0 wt% to less than or equal to 1 wt%, or about 0.5 wt%, based on the total weight of the personal care composition. In yet another embodiment, the preservative comprises sodium benzoate in an amount of from greater than 0 wt% to less than or equal to 2 wt%, from greater than 0 wt% to less than or equal to 1 wt%, or from greater than 0 wt% to less than or equal to 0.8 wt%, based on the total weight of the personal care composition. For example, the personal care composition may comprise sodium benzoate in an amount of about 0.3 wt.%, based on the total weight of the personal care composition. In at least one embodiment, the personal care composition and/or the preservative system thereof can be free or substantially free of phenoxyethanol.
In at least one embodiment, the personal care composition may comprise one or more acids, one or more bases, and/or one or more buffers configured to adjust or control the pH of the personal care composition. The one or more acids, one or more bases, and/or one or more buffering agents may be individually and independently present in an amount of greater than 0 wt% to less than or equal to about 5 wt%, less than or equal to about 4 wt%, less than or equal to about 3 wt%, less than or equal to about 2 wt%, less than or equal to about 1 wt%, less than or equal to about 0.75 wt%, less than or equal to about 0.5 wt%, less than or equal to about 0.4 wt%, or less than or equal to about 0.35 wt%, based on the total weight of the personal care composition or hydrophilic phase thereof. Illustrative bases can include, but are not limited to: ammonia; monoalkylamines, dialkylamines and trialkylamines; monoalkanolamine, dialkanolamine and trialkanolamine; alkali metal and alkaline earth metal hydroxides; sodium hydroxide, potassium hydroxide, lithium hydroxide, monoethanolamine, triethylamine, isopropanolamine, diethanolamine, triethanolamine, the like, or combinations thereof. Illustrative acids can include, but are not limited to, mineral acids such as hydrochloric acid, nitric acid, phosphoric acid, and sulfuric acid; organic acids, polycarboxylic acids such as citric acid, glycolic acid, lactic acid and the like or combinations thereof. In preferred embodiments, the hydrophilic phase comprises at least one acid, such as lactic acid, and the lactic acid is present in an amount of from greater than 0 wt% to about 0.8 wt%, from about 0.4 wt% to about 0.8 wt%, or about 0.65 wt%, based on the total weight of the personal care composition.
The personal care composition may comprise an emulsifying system comprising one or more surfactants and/or one or more emulsifiers. The one or more surfactants and/or one or more emulsifiers may be configured, at least in part, to provide enhanced or relatively greater stability to the personal care composition as compared to conventional personal care compositions. The one or more surfactants and/or emulsifiers may include, but are not limited to, one or more anionic surfactants, one or more cationic surfactants, one or more zwitterionic surfactants, one or more nonionic surfactants, or mixtures thereof. Examples of suitable surfactants can be found in U.S. patent No. 3,959,458 to Agricola et al, U.S. patent No. 3,937,807 to Haefele, and U.S. patent No. 4,051,234 to Gieske et al, the disclosures of which are incorporated herein by reference to the extent consistent with the present disclosure.
Illustrative anionic surfactants can include, but are not limited to: stearic acid, water-soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, such as sodium N-methyl N-cocoyl polyethylene, sodium coconut monoglyceride sulfate. Exemplary anionic surfactants may also comprise higher alkyl sulfates. As used herein, "higher alkyl" refers to C6-30An alkyl group. For example, the anionic surfactant may be or may comprise sodium lauryl sulfate. The anionic surfactant may also comprise a higher alkyl ether sulfate. In another embodiment, the anionic surfactant may comprise higher alkyl aryl sulfonates such as sodium dodecylbenzene sulfonate (sodium dodecylbenzene sulfonate), and higher alkyl sulfoacetates such as sodium lauryl sulfoacetate (sodium lauryl sulfoacetate), higher fatty acid esters of 1,2 dihydroxy propane sulfonate, sulfolaurate (potassium N-2-ethyllaurate sulfoacetamide), and sodium lauryl sarcosinate. In an exemplary embodiment, the anionic surfactant may be or may comprise a water soluble salt of an alkyl sulfate having 10 to 18 carbon atoms in the alkyl radical and a water soluble salt of a sulfonated monoglyceride of a fatty acid having 10 to 18 carbon atoms.
Illustrative cationic surfactants can be or include, but are not limited to, ammonium salts such as distearyldimethylammonium chloride, halide salts of methylated ammonium in which at least one and preferably two or three of the groups on the nitrogen are long chain substantially saturated materials such as tallow fatty groups, hydrogenated tallow fatty groups, methyl sulfate anion salts described above, long chain amide derivatives such as mink oil amidopropyl dimethyl-2-hydroxyethylammonium chloride (quaternary ammonium salt 26), aromatic hydrocarbons such as isododecylbenzyltriethylammonium chloride, N-alkylated amphoteric materials such as N-alkylated betaines, alkylamines, alkylimidazolines, various ethoxylated amines, quaternary ammonium salts-8, -14, -18, -24, -26, -27, -33, -43, -52, -53, and, -60, -62, -83, esterquat, and the like, or any combination thereof. Illustrative esterquats can be or include, but are not limited to, one or more of behenylethyldimethylammonium chloride, dipalmitoylethyldimethylammonium chloride, distearoylethyldimethylammonium chloride, ditalloyl pg-dimethylammonium chloride, dipalmitoylethylmethylammonium methosulfate, distearoylethylhydroxyethylmethylammonium methosulfate, and the like, or combinations and mixtures thereof. In a preferred embodiment, the personal care composition comprises one or more cationic surfactants, and the cationic surfactant comprises dipalmitoylethyldimethylammonium chloride.
Illustrative nonionic surfactants can be or include, but are not limited to: higher alcohols or fatty alcohols, including linear alcohols or ethoxylates thereof; sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerin sorbitan penta-2-ethylhexanoate, diglycerin sorbitan tetra-2-ethylhexanoate, etc.); glycerol polyglycerol aliphatic acids (e.g., cottonseed oil fatty acid glycerol, mono erucic acid glycerol ester, glycerol sesquioleate, glycerol monostearate, glycerol stearate, glycerol pyroglutamate α, α' -oleate, glycerol monostearate malic acid, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); hydrogenated castor oil derivatives; glycerol alkyl ethers, and the like, or combinations thereof. Illustrative nonionic surfactants can be or include, but are not limited to, sorbitan esters and ethoxylated sorbitan esters (e.g., PEG-20 sorbitan isostearate, sorbitan monolaurate, polysorbate-20, polysorbate-40, polysorbate-60, polysorbate-80); ethoxylates (e.g., ceteth-20, PEG-30 castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, laureth-7, isolaureth-6, steareth-10, steareth-20, steareth-21, steareth-100, ceteth-12, oleylpolyether-5, oleylpolyether-10, etc.); ethoxylated adducts (e.g., PEG-25 stearate, glyceryl stearate, PEG-100 stearate, and the like); polyoxyethylene (100) monostearate, polyethylene glycol ester of stearic acid, PEG ester (e.g., PEG-8 oleate, PEG-8 laurate, PEG-8 dilaurate, PEG-12 dilaurate, PEG-80 diisostearate, PEG-40 stearate, etc.); propoxylates (e.g., PPG-10 butanediol, PPG-50 oleyl ether, PPG-2-ceteareth-9, PPG-3-decylether-3, PPG-5-ceteth-20); ethoxylated modified triglycerides (e.g., PEG-20 corn glycerides, PEG-12 palm kernel glycerides); alkylphenol aromatic ethoxylates (e.g., dinonylphenol ethoxylate with 9 moles of EO, octylphenol ethoxylate with 20 moles of EO, octylphenol ethoxylate with 40 moles of EO); block copolymers of alkoxylated diols with ethoxylated and propoxylated segments (e.g., poloxametrm 182 and 234, poloxametrm 105 benzoate, and MEROXAPOLTM 174); and the like or combinations thereof. Illustrative ethoxylates can be or include, but are not limited to, ceteth-20, PEG-30 castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, laureth-7, isolaureth-6, steareth-10, steareth-20, steareth-21, steareth-100, ceteth-12, oleyl-5, oleyl-10.
Illustrative nonionic surfactants can also include, but are not limited to, the reaction product of an aliphatic alcohol or alkylphenol having 6 to 20 carbon atoms in a linear or branched chain with ethylene oxide and/or propylene oxide, wherein the alkylene oxide can be about 6 moles to about 60 moles per mole of alcohol. For example, nonionic surfactants can include, but are not limited to, alkylamine oxides, mono-and dialkyl alkanolamides, polyethylene glycol fatty acid esters, ethoxylated fatty acid amides, saturated fatty acid alcohols reacted with ethylene oxide, alkyl glycosides, and sorbitan ether esters, one or more ceteareth-n such as ceteareth-2, ceteareth-3, ceteareth-4, ceteareth-5, ceteareth-6, ceteareth-7, ceteareth-8, ceteareth-9, ceteareth-10, ceteareth-11, ceteareth-12, ceteareth-13, ceteareth-14, Ceteareth-15, ceteareth-16, ceteareth-17, ceteareth-18, ceteareth-20, ceteareth-22, ceteareth-23, ceteareth-24, ceteareth-25, ceteareth-27, ceteareth-28, ceteareth-29, ceteareth-30, ceteareth-33, ceteareth-34, ceteareth-40, ceteareth-50, ceteareth-55, ceteareth-60, ceteareth-80, ceteareth-100 and the like or combinations thereof or one or more ceteareth combinations fatty acid alcohols such as stearyl alcohol, a, Oleyl alcohol, linoleyl alcohol, arachidyl alcohol, cetyl alcohol, cetostearyl alcohol (i.e., a mixture of cetyl alcohol and stearyl alcohol), and the like, or any combination thereof. It will be appreciated that ceteareth-n is the name for the INCI family and refers to the polyoxyethylene ether of mixtures of high molecular weight saturated fatty alcohols, where 'n' indicates the average number of ethylene oxide residues in the polyoxyethylene chain. In exemplary embodiments, the nonionic surfactant comprises cetearyl alcohol, ceteareth-20, cetyl alcohol, stearyl alcohol, or combinations thereof. It should be understood that ceteareth-20 (CAS number 68439-49-6) is the polyethylene glycol ether of cetearyl alcohol.
The nonionic surfactant may comprise one or more fatty or higher alcohols. Illustrative fatty or higher alcohols can be or include, but are not limited to, straight chain alcohols, such as C12-22Fatty alcohol, or preferably C16-18Fatty alcohols, lauryl alcohol, myristyl alcohol, cetyl alcohol, behenyl alcohol, stearyl alcohol, cetearyl alcohol 50/50, and the like, or combinations thereof. Illustrative fatty alcohols can also include branched chain alcohols such as monostearyl glyceryl ether (batyl alcohol), 2-decyltetradecanol, lanolin alcohol, cholesterol, phytosterols, hexyldodecanol, isostearyl alcohol, octyldodecanol, and the like, or combinations thereof. In a preferred embodiment, the personal care composition or emulsifying system thereof comprises cetearyl alcohol, ceteareth-20, cetyl alcohol, stearyl alcohol.
The amount of each of the one or more surfactants and/or emulsifiers present in the personal care composition or emulsified system thereof can vary widely. For example, each of the one or more surfactants and/or emulsifiers may be individually and independently present in an amount of from about greater than 0 wt% to less than or equal to about 20 wt%, based on the total weight of the personal care composition or emulsified system thereof. For example, each of the one or more surfactants and/or emulsifiers may be individually and independently present in an amount of about greater than 0 wt%, 0.25 wt%, about 0.5 wt%, about 0.75 wt%, about 1 wt%, about 1.25 wt%, about 1.5 wt%, about 1.75 wt%, about 2 wt%, about 2.25 wt%, about 2.5 wt%, or about 3 wt% to about 3.5 wt%, about 4 wt%, about 4.5 wt%, about 5 wt%, about 5.5 wt%, about 6 wt%, or more, based on the total weight of the personal care composition or emulsified system thereof. In another example, each of the one or more surfactants and/or emulsifiers may be individually and independently present in an amount of from about greater than 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, about 5 wt%, about 6 wt%, or about 7 wt% to about 8 wt%, about 9 wt%, about 10 wt%, about 11 wt%, about 12 wt%, about 13 wt%, about 14 wt%, about 15 wt%, or about 20 wt%, based on the total weight of the personal care composition or emulsified system thereof.
In at least one embodiment, the weight ratio of any one surfactant or emulsifier to any other surfactant or emulsifier in the emulsification system can vary from about 0.1:1 to about 3: 1. For example, the weight ratio of any one surfactant/emulsifier to any other surfactant/emulsifier in the emulsifying system may be about 0.1:1, about 0.2:2, about 0.3:1, about 0.4:1, about 0.5:1, about 0.6:1, about 0.7:1, about 0.8:1, or about 0.9:1 to about 1:1, about 1.1:1, about 1.2:1, about 1.3:1, about 1.4:1, about 1.5:1, about 2:1, about 2.5:1, or about 3: 1.
In at least one embodiment, the weight ratio of any one or more of the emulsifiers to any one or more of the stabilizers can be from about 1:1 to about 1.5: 1. For example, ceteareth-20 and the weight ratio of cetearyl alcohol to cetyl alcohol and/or stearyl alcohol may be from about 1:1 to about 1.5: 1. In another embodiment, the weight ratio of any one or more of the stabilizing agents to any one or more of the emollients may be from about 1:1 to about 3: 1.
The personal care compositions disclosed herein may comprise one or more emollients. The one or more emollients may be configured to maintain the soft, smooth, and pliable appearance of the skin. The one or more emollients may be or include, but are not limited to, fatty esters, fatty alcohols, or combinations thereof. Illustrative emollients may be or include, but are not limited to, diisopropyl adipate, oleyl alcohol, lanolin, isopropyl myristate, isopropyl palmitate, coco-caprylate, diethylhexyl carbonate, caprylic/capric triglyceride, cetyl lactate, cetyl palmitate, hydrogenated castor oil, glyceryl esters, hydroxycetyl isostearate, hydroxycetyl phosphate, isopropyl isostearate, isostearic acid, diisopropyl sebacate, polyoxypropylene (5) polyoxyethylene (20) cetyl ether (PPG-5-Ceteth-20), ethylhexyl 2-isononanoate, ethylhexyl 2-stearate, C5-Ceteth-2012To C16Fatty alcohol, C12To C16Fatty alcohol lactate, isopropyl lanolate, ethyl-hexyl 2-salicylate, and the like, or combinations thereof. In some embodiments, the one or more emollients may be a combination of fatty alcohols. In some embodiments, the one or more emollients may be 1-hexadecanol, acetylated lanolin, behenoyloxy polydimethylsiloxane, C12-15Alkyl benzoate, cetearyl caprylate, glyceryl cocoate, dimethicone copolyol dicaprylate/dicaprate, dimethiconol, dioctyl adipate, glyceryl stearate, isocetyl alcohol, isohexadecane, isopentyl cyclohexanone, isopropyl palmitate, lauryl lactate, mineral oil, methoxypeg-22/dodecyl glycol copolymer, myristyl lactate, octyldodecyl neopentanoate, octyl cocoate, octyl palmitate, octyl stearate, octyldodecyl neopentanoate, polyglyceryl-4 isostearate, polyethylene glycol 40 stearic acid, polyoxymethylene urea, potassium sorbate, propylene glycol isoceth-3 acetate, propylene glycol myristyl ether acetate, or combinations thereof. Say thatThe skin lightening emollient may also include, but is not limited to, high molecular weight saturated and unsaturated fatty alcohols such as, but not limited to, carbitol, lauryl alcohol, myristyl alcohol, cetyl alcohol, isocetyl alcohol, stearyl alcohol, isostearyl alcohol, hydroxystearyl alcohol, oleyl alcohol, ricinoleyl alcohol, behenyl alcohol, erucyl alcohol, 2-octyldodecanol, cetearyl alcohol, lanolin alcohol, and the like, or any combination thereof. As discussed above, in at least one embodiment, the personal care composition can be free or substantially free of silicone and/or silicone compounds. Thus, the personal care composition may be free or substantially free of behenoyloxy dimethicone, dimethicone copolyol dicaprylate/dicaprate dimethicone copolyol, dimethiconol, and the like.
In a preferred embodiment, the emollient may be selected from isopropyl palmitate, coco-caprylate, coco glyceride, di-ethylhexyl carbonate, or combinations thereof.
In at least one embodiment, the personal care compositions disclosed herein may comprise one or more emollients in an amount ranging from greater than 0% to about 5% by weight, based on the total weight of the personal care composition. For example, one or more emollients may be present in an amount of greater than 0%, about 0.1%, about 0.3%, about 0.5%, about 1%, or about 2% to about 2.5%, about 3%, about 3.5%, about 4%, or about 5% by weight, based on the total weight of the personal care composition.
In at least one embodiment, the emollient system can comprise one or more stabilizers. The one or more stabilizing agents may be or include, but are not limited to, cetyl alcohol, stearyl alcohol, or combinations thereof. The one or more stabilizers may be present in an amount of from greater than 0 wt% to about 5 wt%, based on the total weight of the personal care composition. For example, the one or more stabilizing agents may be present in an amount of greater than 0 wt%, about 0.1 wt%, about 0.3 wt%, about 0.5 wt%, about 1 wt%, or about 2 wt% to about 2.5 wt%, about 3 wt%, about 3.5 wt%, about 4 wt%, or about 5 wt%, based on the total weight of the personal care composition.
In preferred embodiments, the personal care composition or emulsifying system thereof may comprise a combination of dipalmitoylethyldimethylammonium chloride, cetearyl alcohol/ceteareth-20, stearyl alcohol, cetyl alcohol, isopropyl palmitate or combinations thereof.
In some embodiments, the personal care composition may comprise one or more skin care agents. Any suitable skin care agent that does not adversely affect the stability and/or efficacy of the personal care composition can be used. The skin care agent may typically comprise one or more polymers (e.g., polyvinylpyrrolidone), starches (e.g., tapioca starch, hydrophobically modified corn starch, such as DRY-FLO)CAS No. 68989-12-8, 68554-70-1, 9005-25-8, and the like), protein derivatives (e.g., derivatized hydrolyzed wheat protein), ethoxylated fatty ethers, cellulose (e.g., hydroxyethyl cellulose), and the like or combinations thereof. Illustrative skin care agents can include, but are not limited to, esters (e.g., isopropyl myristate, decyl oleate, cetearyl isononanoate, and the like) comprising aliphatic alcohols having from about 2 to about 18 carbon atoms condensed with aliphatic or aromatic carboxylic acids containing from about 8 to about 20 carbon atoms. The esters may be linear or branched. In a preferred embodiment, the ester has a molecular weight of less than about 500.
Other skin care agents may include, but are not limited to, polyvinylpyrrolidone, polyquaternium-4, polyquaternium-7, polyquaternium-10, guar gum derivatives, hydroxypropyl methylcellulose, hydroxyethyl cellulose, polyethylene glycol, methyl ether of polyethylene glycol, quaternium-79, wheat germ amidopropyl hydroxypropyl dimethyl ammonium hydrolyzed wheat protein, stearyl methicone, dimethicone copolyol, dimethicone propyl PG betaine, poly (sodium styrene sulfonate), sorbitan oleate, steareth-2, steareth-21, isocetyleth-20, PEG-7 glyceryl cocoate, PEG-75 lanolin, glyceryl polyether-26, PPG-5-cetyl polyether-20, C-lanolin12-C20Alcohol, low erucic acid rapeseed oil, lauric glyceride, glycerin monostearate, and glycerin monostearateOleyl ester, vitamin E acetate, sunflower seed amidopropyl ethyl dimethyl ammonium ethyl sulfate, PEG-7 sodium olive oil carboxylate, PPG-1 hydroxyethyl caprylamide, PPG-2 hydroxyethyl cocamide, mineral oil, petrolatum, aloe vera, isostearamidopropyl morpholine lactate, strontium acetate, palmitoylamidopropyl trimethyl ammonium chloride, and the like, or combinations thereof. In a preferred embodiment, the skin care agent is or comprises a conditioning agent, such as a cationic cellulose polymer (e.g., polyquaternium-7). As indicated above, the personal care composition may be free or substantially free of any one or more of PEG, mineral oil, and petrolatum. Thus, the personal care composition or other skin care agent thereof may not comprise PEG, mineral oil, and/or petrolatum.
The personal care composition may comprise one or more additional optional ingredients. Illustrative optional ingredients may include, but are not limited to, one or more dyes, fragrances, preservatives, thickeners, viscosity modifiers, antioxidants, chelating agents (e.g., EDTA, phosphates, etc.), opacifiers, hydrogen-containing solvents, hydrotropes, antimicrobials, and the like, or any combination thereof. In at least one embodiment, the personal care composition can be free or substantially free of parabens.
The personal care composition may comprise water. The water may be deionized, demineralized, and/or demineralized water. Water may constitute the balance of the personal care composition. For example, the amount of water present in the personal care composition can be greater than 60 wt.%, greater than 65 wt.%, greater than 70 wt.%, greater than 75 wt.%, greater than 80 wt.%, greater than 85 wt.%, greater than 90 wt.%, greater than 92 wt.%, greater than 94 wt.%, greater than 96 wt.%, or more, based on the total weight of the personal care composition. The amount of water in the personal care composition can include added free water and water introduced with other components or materials of the personal care composition. For example, the amount of water in the personal care composition can comprise free water and water associated with one or more surfactants and/or any other components of the personal care composition.
Method
The present disclosure can provide a method for preparing a stable personal care composition. In particular, the present disclosure may provide methods for preparing stable, low pH personal care compositions that are free or substantially free of silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof. The present disclosure can also provide methods for preventing separation of hydrophobic and hydrophilic phases in a personal care composition that is free or substantially free of silicones, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof when exposed to various aging conditions. It will be appreciated by those of ordinary skill in the art that aging conditions may be provided or defined by the International coordination office (ICH) guidelines for human drug requirements. The method may comprise mixing, combining, stirring, emulsifying, or otherwise contacting two or more components/ingredients disclosed herein with each other. The method may also comprise heating the components/ingredients before, during, or after mixing, combining, stirring, emulsifying, or otherwise contacting the components with one another. The method can comprise preparing a hydrophobic phase and a hydrophilic phase, and contacting the hydrophobic phase with the hydrophilic phase. For example, the method can comprise preparing a hydrophobic phase comprising one or more components disclosed herein, preparing a hydrophilic phase comprising one or more components disclosed herein, and mixing, combining, stirring, emulsifying, or otherwise contacting the hydrophobic phase and the hydrophilic phase with one another. The method may further comprise heating the hydrophilic phase and/or the hydrophobic phase while mixing, combining, stirring, emulsifying, or otherwise bringing the hydrophobic phase and the hydrophilic phase into contact with each other. The hydrophobic and/or hydrophilic phase may be heated at a temperature of from about 60 ℃ to about 90 ℃, from about 65 ℃ to about 85 ℃, from about 70 ℃ to about 80 ℃, or from about 75 ℃ to about 80 ℃.
The method for preparing a stable personal care composition may further comprise preparing an emulsifying system comprising one or more surfactants and/or emulsifiers to enhance the stability of the personal care composition. The method of preparing the emulsifying system may comprise mixing, combining, stirring, or otherwise contacting the one or more surfactants and/or emulsifiers with each other. For example, the method of preparing the emulsification system may comprise mixing, combining, stirring, or otherwise contacting dipalmitoylethyldimethylammonium chloride, cetearyl alcohol, and ceteareth-20, stearyl alcohol, isopropyl palmitate, cetyl alcohol, or any combination thereof with one another.
All ingredients used in the compositions described herein should be topically acceptable. As used herein, "topically acceptable" may refer to any ingredient present in the composition as described in an amount and in a form that does not render the use of the composition unsafe on the skin surface.
Examples of the invention
The examples and other embodiments described herein are exemplary and are not intended to limit the full scope of the compositions and methods described herein. Equivalent changes, modifications and variations of specific embodiments, materials, compositions and methods may be made within the scope of the present disclosure, with substantially similar results.
Example 1
Test personal care compositions (1) - (17) were prepared by combining ingredients/components according to tables 1A and 1B. Specifically, dipalmitoylethyldimethylammonium chloride, cetearyl alcohol and ceteareth-20, the amounts of stearyl alcohol and cetyl alcohol were combined according to tables 1A and 1B, and the remaining components were combined according to the ranges provided in table 1C. Typically, the ingredients/components of each of the test personal care compositions (1) - (17) were combined according to the ranges disclosed in table 1D. As indicated in tables 1A and 1B, it should be appreciated that the amount of dipalmitoylethyldimethylammonium chloride is typically present in an amount of about 0.3% to about 0.5%, and that all remaining raw materials are typically kept constant, except for water, which is adjusted to accommodate variations in the amount of cetearyl alcohol/ceteareth-20, stearyl alcohol, cetyl alcohol, isopropyl palmitate, or combinations thereof.
TABLE 1A
Personal care compositions (1) - (8)
Weight (%)
Components | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Dipalmitoylethyl dimethyl ammonium chloride | 0.50 | 0.30 | 0.30 | 0.50 | 0.30 | 0.50 | 0.30 | 0.30 |
Cetearyl alcohol/ceteareth-20 | 2.00 | 4.00 | 4.00 | 4.00 | 4.00 | 2.00 | 2.00 | 2.00 |
Stearyl alcohol | 1.50 | 3.00 | 3.00 | 3.00 | 1.50 | 3.00 | 1.50 | 1.50 |
Cetyl alcohol | 3.50 | 1.50 | 3.50 | 1.50 | 3.50 | 1.50 | 1.50 | 3.50 |
Palmitic acid isopropyl ester | 4.00 | 4.00 | 1.50 | 1.50 | 4.00 | 4.00 | 4.00 | 1.50 |
TABLE 1B
Personal care compositions (9) - (17)
Weight (%)
Components | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
Dipalmitoylethyl dimethyl ammonium chloride | 0.50 | 0.30 | 0.50 | 0.50 | 0.50 | 0.30 | 0.30 | 0.40 | 0.50 |
Cetearyl alcohol/ceteareth-20 | 2.00 | 2.00 | 4.00 | 2.00 | 4.00 | 2.00 | 4.00 | 3.00 | 4.00 |
Stearyl alcohol | 3.00 | 3.00 | 1.50 | 1.50 | 1.50 | 3.00 | 1.50 | 2.25 | 3.00 |
Cetyl alcohol | 3.50 | 1.50 | 3.50 | 1.50 | 1.50 | 3.50 | 1.50 | 2.50 | 3.50 |
Palmitic acid isopropyl ester | 1.50 | 1.50 | 1.50 | 1.50 | 4.00 | 4.00 | 1.50 | 2.75 | 4.00 |
TABLE 1C
The remaining ingredients of personal care compositions (1) - (17)
Components | Range |
Deionized water | 72-80 |
Octylene glycol | 0.1-3 |
Preservative | 0.1-3 |
Acid(s) | 0.1-2 |
Glycerol | 1-6 |
Amino acids | 0.1-4 |
Coconut oil glyceride | 1-4 |
Coconut oil alcohol-caprylic acid ester | 1-4 |
Diethylhexylcarbonate | 0.1-3 |
TABLE 1D
Amounts of personal care compositions (1) - (17)
Components | Range |
Water (W) | QS |
Wetting agent | 1-6 |
Preservative | 0.5-1.5 |
Cationic surfactant | 0.1-2 |
Nonionic surfactant | 2-4 |
Fatty alcohols | 0.5-4 |
Emollient/skin conditioner | 0.1-5 |
Example 2
The stability of each of the test personal care compositions (1) - (17) prepared in example 1 was evaluated. Specifically, the stability of each of the test personal care compositions (1) - (17) of example 1 was evaluated by measuring or observing pH and viscosity under various accelerated aging conditions.
To evaluate the viscosity under various accelerated aging conditions, each of the test personal care compositions (1) - (17) was placed in a respective glass jar and exposed to an environment maintained at the specific conditions (e.g., time and temperature) indicated in table 2. After the respective time of each of the studies, each of the personal care compositions was removed from the environment and allowed to cool in a monitored stability chamber maintained at about 25 ℃. After cooling to about 25 ℃, the viscosity and pH were measured and the personal care composition was visually observed/evaluated. The viscosity was measured using a Brookfield rheometer with rotor T-93 at 10RPM for about 1 minute.
The results of the pH and viscosity stability analyses testing personal care compositions (1) - (17) are summarized in tables 2 and 3, respectively. It should be understood that based on the definition of "relatively more stable" disclosed herein, a personal care composition is considered relatively more stable if no separation is observed and the viscosity and pH values are considered relatively more stable throughout the course of the analysis.
TABLE 2
Control and test pH of personal care compositions (C) and (1) - (17)A
ASeperating the phases;
Baging conditions are as follows: freeze thawing at-30 ℃; 3 cycles of
CAging conditions are as follows: freezing and thawing at-10 ℃; 3 cycles of
TABLE 3
ControlAnd testing the viscosity (cP) of personal care compositions (C) and (1) - (17)A
ASeperating the phases;
Baging conditions are as follows: freeze thawing at-30 ℃; 3 cycles of
CAging conditions are as follows: freezing and thawing at-10 ℃; 3 cycles of
As shown in tables 2 and 3, personal care compositions (3), (11), and (17) remained stable by maintaining acceptable pH and viscosity values, and did not exhibit any phase separation under various accelerated aging conditions. It was observed that the physical properties of personal care compositions (3), (11) and (17) also remained unchanged under various accelerated aging conditions. Specifically, the color, odor and appearance of personal care compositions (3), (11) and (17) remained unchanged throughout the various accelerated aging conditions.
It should be understood that personal care compositions (3), (11) and (17) all contain about 4% cetearyl alcohol and ceteareth-20 and about 3.5% cetyl alcohol.
As indicated above, personal care composition (3) comprises stearyl alcohol in an amount of about 3%, which results in a combined total fatty alcohol content of cetyl alcohol and stearyl alcohol of about 6.5%. Personal care composition (3) also contained isopropyl palmitate in an amount of about 1.5%.
Personal care composition (11) comprises stearyl alcohol in an amount of about 1.5% and cetyl alcohol in an amount of about 3.5%, thereby providing about 5% total fatty alcohols. Personal care composition (11) also comprises isopropyl palmitate in an amount of about 1.5%.
The personal care composition (17) comprises stearyl alcohol in an amount of about 3%, cetyl alcohol in an amount of about 3.5%, thereby providing about 6.5% total fatty alcohols. Personal care composition (11) also comprises isopropyl palmitate in an amount of about 1.5%.
It was surprisingly found that personal care composition (17) was the only stable personal care composition comprising isopropyl palmitate in an amount of about 4%.
It has been surprisingly and unexpectedly found that stable personal care compositions having a pH of from about 4 to about 5 can be prepared when the primary emulsifiers, i.e., cetearyl alcohol and ceteareth-20, are present in an amount of about 4%, the combined amount of cetyl and stearyl alcohol is present in an amount of greater than or equal to about 5%, and cetyl alcohol is present in an amount of 3.5% or greater. It has also been surprisingly and unexpectedly found that stable personal care compositions having a pH of from about 4 to about 5 can be prepared when isopropyl palmitate is present in an amount of about or at least 1.5%. It has further been surprisingly and unexpectedly found that stable personal care compositions having a pH of from about 4 to about 5 can be prepared by providing cetyl alcohol and stearyl alcohol in an amount of about 6.5% or greater and/or cetearyl alcohol/ceteareth-20 in an amount of about 4% or greater in total if isopropyl palmitate is present in an amount of about 4%.
Example 3
Whiteness, absorbency, spreadability, tack and greasiness were also evaluated. To evaluate whiteness, absorbability, tack, spreadability and greasiness, a sensory panel consisting of ten panelists evaluating sensory properties was used. Each of the ten panelists evaluated each of the test personal care compositions (3), (11), and (17) using a standardized method and a 0 to 5 point rating scale, where '0' represents the lowest level (i.e., none or low) and '5' represents the highest value. A controlled amount of each of the test personal care compositions (3), (11) and (17) was used for the analysis. The results of analyzing the sensory characteristics of personal care compositions (3), (11) and (17) are summarized in table 4.
TABLE 4
Sensory Properties of personal Care compositions (3), (11) and (17)
CW is whiteness; a is absorbency; s-spreadability; t ═ tackiness; greasiness property
The present disclosure has been described with reference to exemplary embodiments. While a limited number of embodiments have been shown and described, it will be appreciated by those skilled in the art that changes may be made in these embodiments without departing from the principles and spirit of the embodiments described previously. It is intended that the present disclosure be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (17)
1. A personal care composition, comprising:
an emulsification system;
one or more emollients; and
one or more humectants.
2. The personal care composition of claim 1, wherein the emulsifying system comprises a cationic surfactant, optionally the cationic surfactant comprises an esterquat, further optionally the esterquat comprises one or more of: behenylethyldimethylammonium chloride, dipalmitoylethyldimethylammonium chloride, distearoylethyldimethylammonium chloride, ditalloyl pg-dimethylammonium chloride, dipalmitoylethyl-ammonium methyl sulfate, distearoylethylhydroxyethylammonium methyl sulfate, or a combination thereof, further optionally, the cationic surfactant comprises dipalmitoylethyldimethylammonium chloride.
3. The personal care composition of any preceding claim, wherein the emulsification system comprises one or more nonionic surfactants, optionally, the one or more nonionic surfactants comprise cetearyl alcohol, ceteareth-20, cetyl alcohol, stearyl alcohol, or a combination thereof.
4. The personal care composition of claim 3, wherein cetearyl alcohol and ceteareth-20 are present in an amount from about 3 wt% to about 5 wt%, optionally in an amount of about 4 wt%, based on the total weight of the personal care composition.
5. The personal care composition of claims 3 and 4, wherein the cetyl alcohol and the stearyl alcohol are present in an amount of greater than or equal to about 5 wt%, based on the total weight of the personal care composition.
6. The personal care composition of any one of claims 3 to 5, wherein the cetyl alcohol is present in an amount of greater than or equal to about 3 wt%, optionally about 3.5 wt%, based on the total weight of the personal care composition.
7. The personal care composition of any preceding claim, wherein the one or more emollients comprise isopropyl palmitate.
8. The personal care composition of claim 7, wherein the isopropyl palmitate is present in an amount greater than or equal to about 1.5 wt% based on the total weight of the personal care composition.
9. The personal care composition of claim 7, wherein:
the isopropyl palmitate is present in an amount greater than or equal to about 4 wt.%, based on the total weight of the personal care composition,
the cetyl alcohol and the stearyl alcohol are present in an amount of greater than or equal to about 6.5 wt%, based on the total weight of the personal care composition, and
the nonionic surfactant comprises cetearyl alcohol and ceteareth-20 in an amount greater than or equal to about 4 wt%, based on the total weight of the personal care composition.
10. The personal care composition of any preceding claim, wherein the one or more humectants comprises glycerin, caprylyl glycol, or a combination thereof.
11. The personal care composition of any preceding claim, wherein the personal care composition is substantially free of silicone, silicone compounds, propylene glycol, mineral oil, petrolatum, polyethylene glycol (PEG), or any combination thereof.
12. The personal care composition of any preceding claim, wherein the personal care composition is substantially free of silicone, silicone compounds, propylene glycol, mineral oil, petrolatum, or any combination thereof.
13. The personal care composition of any preceding claim, further comprising one or more acids, optionally the acid comprises lactic acid.
14. The personal care composition of any preceding claim, wherein the personal care composition has an acidic pH, optionally the pH is from about 4 to about 6, further optionally the pH is from about 4 to about 5.
15. The personal care composition of any preceding claim, wherein the personal care composition has a viscosity of greater than or equal to 50,000 centipoise (cP) and less than or equal to 200,000cP at 25 ℃.
16. The personal care composition of any preceding claim, wherein the personal care composition exhibits no phase separation after exposure to accelerated aging conditions.
17. A process for preparing a personal care composition according to any preceding claim, comprising contacting the emulsifying system, the one or more emollients, and the one or more humectants with one another.
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PCT/US2019/059439 WO2021086403A1 (en) | 2019-11-01 | 2019-11-01 | STABLE LOW pH PERSONAL CARE COMPOSITIONS AND METHODS FOR THE SAME |
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EP (1) | EP4017455A1 (en) |
CN (1) | CN114599334A (en) |
AU (1) | AU2019472201B2 (en) |
BR (1) | BR112022007671A2 (en) |
CA (1) | CA3158619A1 (en) |
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WO (1) | WO2021086403A1 (en) |
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- 2019-11-01 EP EP19809960.8A patent/EP4017455A1/en active Pending
- 2019-11-01 BR BR112022007671A patent/BR112022007671A2/en unknown
- 2019-11-01 WO PCT/US2019/059439 patent/WO2021086403A1/en unknown
- 2019-11-01 MX MX2022004967A patent/MX2022004967A/en unknown
- 2019-11-01 AU AU2019472201A patent/AU2019472201B2/en active Active
- 2019-11-01 CN CN201980101674.1A patent/CN114599334A/en active Pending
- 2019-11-01 CA CA3158619A patent/CA3158619A1/en active Pending
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BR112022007671A2 (en) | 2022-08-09 |
EP4017455A1 (en) | 2022-06-29 |
AU2019472201A1 (en) | 2022-05-12 |
MX2022004967A (en) | 2022-05-18 |
CA3158619A1 (en) | 2021-05-06 |
WO2021086403A1 (en) | 2021-05-06 |
AU2019472201B2 (en) | 2024-05-02 |
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