CN114574286A - 一种具有抗炎活性的胡椒精油及其制备方法 - Google Patents
一种具有抗炎活性的胡椒精油及其制备方法 Download PDFInfo
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- CN114574286A CN114574286A CN202210152457.9A CN202210152457A CN114574286A CN 114574286 A CN114574286 A CN 114574286A CN 202210152457 A CN202210152457 A CN 202210152457A CN 114574286 A CN114574286 A CN 114574286A
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- essential oil
- pepper
- pepper essential
- fresh
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Links
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Seasonings (AREA)
Abstract
Description
Claims (10)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210152457.9A CN114574286B (zh) | 2022-02-18 | 2022-02-18 | 一种具有抗炎活性的胡椒精油及其制备方法 |
GB2214556.9A GB2620210A (en) | 2022-02-18 | 2022-05-19 | Pepper essential oil with anti-inflammatory activity and preparation method thereof |
PCT/CN2022/093758 WO2023155315A1 (zh) | 2022-02-18 | 2022-05-19 | 一种具有抗炎活性的胡椒精油及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210152457.9A CN114574286B (zh) | 2022-02-18 | 2022-02-18 | 一种具有抗炎活性的胡椒精油及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN114574286A true CN114574286A (zh) | 2022-06-03 |
CN114574286B CN114574286B (zh) | 2024-03-22 |
Family
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Family Applications (1)
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CN202210152457.9A Active CN114574286B (zh) | 2022-02-18 | 2022-02-18 | 一种具有抗炎活性的胡椒精油及其制备方法 |
Country Status (2)
Country | Link |
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CN (1) | CN114574286B (zh) |
WO (1) | WO2023155315A1 (zh) |
Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100089348A (ko) * | 2009-02-03 | 2010-08-12 | 김경수 | 피페린을 유효성분으로 함유하는 염증과 통증 억제 또는 치료용 약학 조성물 |
US20110135760A1 (en) * | 2007-08-16 | 2011-06-09 | Virdis Pharmaceutical Limited | Use of Extracts or Materials Extracted From Piper Cubeba L. as an Effective Component in a Drug for the Treatment of Cancer Diseases |
CN102260594A (zh) * | 2011-08-01 | 2011-11-30 | 晨光生物科技集团股份有限公司 | 从胡椒中提取胡椒精油和胡椒油树脂的方法 |
KR20120056243A (ko) * | 2012-05-02 | 2012-06-01 | 주식회사한국전통의학연구소 | 피페린 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 염증성 질환 예방 및 치료용 조성물 |
CN102586023A (zh) * | 2012-01-19 | 2012-07-18 | 仲恺农业工程学院 | 一种柑橘类果皮精油的提取方法 |
KR20130023177A (ko) * | 2011-08-26 | 2013-03-07 | 주식회사한국전통의학연구소 | 호초 추출물을 포함하는 췌장암 치료용 조성물 및 화장료 조성물 |
CN103981029A (zh) * | 2014-05-21 | 2014-08-13 | 中国热带农业科学院香料饮料研究所 | 一种香草兰豆荚提取物、其制备方法和应用 |
CN104774692A (zh) * | 2015-03-18 | 2015-07-15 | 吉林化工学院 | 一种黑胡椒挥发油的提取方法 |
CN105349245A (zh) * | 2015-11-04 | 2016-02-24 | 邵素英 | 一种高生物活性苦杏仁油及其提取方法 |
CN105969511A (zh) * | 2016-05-26 | 2016-09-28 | 安徽科技学院 | 一种芝麻油的提取方法 |
US20160354471A1 (en) * | 2015-06-04 | 2016-12-08 | Antonino Cavallaro | Pine Bark Extract and Black Pepper Essential Oil with Anti-Inflammatory and Anti-Arthritic Action and Method of Preparing |
KR20180035575A (ko) * | 2016-09-29 | 2018-04-06 | 코웨이 주식회사 | 히그로필라 메가란타 추출물을 포함하는 항염증 조성물 |
CN109097182A (zh) * | 2018-08-15 | 2018-12-28 | 合肥市金乡味工贸有限责任公司 | 一种冷冻微波解冻协同水酶法制备脱皮芝麻油的方法 |
CN109628221A (zh) * | 2018-11-29 | 2019-04-16 | 广州柚子舍生物科技有限公司 | 柚子花精油的提取方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2966700B1 (fr) * | 2010-10-29 | 2013-01-11 | Bernard Mompon | Procede de fabrication d?articles d?origine vegetale impregnes de substance liquide vegetale |
CN103039931A (zh) * | 2013-01-08 | 2013-04-17 | 中国热带农业科学院香料饮料研究所 | 一种胡椒油树脂及其制备方法 |
CN103349006A (zh) * | 2013-07-16 | 2013-10-16 | 东北林业大学 | 黑胡椒精油微胶囊及其制备方法 |
CN103484256A (zh) * | 2013-10-11 | 2014-01-01 | 青岛农业大学 | 一种用水蒸气蒸馏提取牡丹雄蕊挥发油的方法 |
CN106900884A (zh) * | 2017-02-27 | 2017-06-30 | 赵勇 | 一种山核桃油及山核桃粉的制备方法 |
CN107223943B (zh) * | 2017-06-20 | 2021-06-15 | 中国热带农业科学院香料饮料研究所 | 一种胡椒鲜果复合调味汁及其制备方法 |
CN107281032A (zh) * | 2017-07-01 | 2017-10-24 | 马南行 | 一种美白祛斑的组合物及其制备方法 |
CN109554227A (zh) * | 2017-09-26 | 2019-04-02 | 秭归县屈姑食品有限公司 | 一种柑橘精油提取装置 |
CN110591819A (zh) * | 2019-09-04 | 2019-12-20 | 大冶海通热工技术有限公司 | 一种保持天然花香的精油提取方法 |
CN112063305B (zh) * | 2020-09-17 | 2022-06-10 | 中国热带农业科学院香料饮料研究所 | 一种胡椒鲜果油树脂及其制备方法 |
-
2022
- 2022-02-18 CN CN202210152457.9A patent/CN114574286B/zh active Active
- 2022-05-19 WO PCT/CN2022/093758 patent/WO2023155315A1/zh unknown
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110135760A1 (en) * | 2007-08-16 | 2011-06-09 | Virdis Pharmaceutical Limited | Use of Extracts or Materials Extracted From Piper Cubeba L. as an Effective Component in a Drug for the Treatment of Cancer Diseases |
KR20100089348A (ko) * | 2009-02-03 | 2010-08-12 | 김경수 | 피페린을 유효성분으로 함유하는 염증과 통증 억제 또는 치료용 약학 조성물 |
CN102260594A (zh) * | 2011-08-01 | 2011-11-30 | 晨光生物科技集团股份有限公司 | 从胡椒中提取胡椒精油和胡椒油树脂的方法 |
KR20130023177A (ko) * | 2011-08-26 | 2013-03-07 | 주식회사한국전통의학연구소 | 호초 추출물을 포함하는 췌장암 치료용 조성물 및 화장료 조성물 |
CN102586023A (zh) * | 2012-01-19 | 2012-07-18 | 仲恺农业工程学院 | 一种柑橘类果皮精油的提取方法 |
KR20120056243A (ko) * | 2012-05-02 | 2012-06-01 | 주식회사한국전통의학연구소 | 피페린 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 염증성 질환 예방 및 치료용 조성물 |
CN103981029A (zh) * | 2014-05-21 | 2014-08-13 | 中国热带农业科学院香料饮料研究所 | 一种香草兰豆荚提取物、其制备方法和应用 |
CN104774692A (zh) * | 2015-03-18 | 2015-07-15 | 吉林化工学院 | 一种黑胡椒挥发油的提取方法 |
US20160354471A1 (en) * | 2015-06-04 | 2016-12-08 | Antonino Cavallaro | Pine Bark Extract and Black Pepper Essential Oil with Anti-Inflammatory and Anti-Arthritic Action and Method of Preparing |
CN105349245A (zh) * | 2015-11-04 | 2016-02-24 | 邵素英 | 一种高生物活性苦杏仁油及其提取方法 |
CN105969511A (zh) * | 2016-05-26 | 2016-09-28 | 安徽科技学院 | 一种芝麻油的提取方法 |
KR20180035575A (ko) * | 2016-09-29 | 2018-04-06 | 코웨이 주식회사 | 히그로필라 메가란타 추출물을 포함하는 항염증 조성물 |
CN109097182A (zh) * | 2018-08-15 | 2018-12-28 | 合肥市金乡味工贸有限责任公司 | 一种冷冻微波解冻协同水酶法制备脱皮芝麻油的方法 |
CN109628221A (zh) * | 2018-11-29 | 2019-04-16 | 广州柚子舍生物科技有限公司 | 柚子花精油的提取方法 |
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