CN114522213A - Herbal atomized composition for improving memory and preparation method thereof - Google Patents

Herbal atomized composition for improving memory and preparation method thereof Download PDF

Info

Publication number
CN114522213A
CN114522213A CN202210028830.XA CN202210028830A CN114522213A CN 114522213 A CN114522213 A CN 114522213A CN 202210028830 A CN202210028830 A CN 202210028830A CN 114522213 A CN114522213 A CN 114522213A
Authority
CN
China
Prior art keywords
parts
powder
composition
herbal
memory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210028830.XA
Other languages
Chinese (zh)
Inventor
杨继广
杨占文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qihuang Treasure Beijing Technology Co ltd
Original Assignee
Qihuang Treasure Beijing Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qihuang Treasure Beijing Technology Co ltd filed Critical Qihuang Treasure Beijing Technology Co ltd
Priority to CN202210028830.XA priority Critical patent/CN114522213A/en
Publication of CN114522213A publication Critical patent/CN114522213A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/41Crassulaceae (Stonecrop family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9062Alpinia, e.g. red ginger or galangal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the technical field of Chinese herbal medicine atomized products, and discloses a herbal atomized composition for improving memory and a preparation method thereof. The composition is prepared from pure plant Chinese herbal medicines, is pungent in taste and warm in nature; the spleen and kidney meridians are the therapeutic principles. Fructus Alpinae Oxyphyllae can improve memory; the black sesame can tonify essence and blood; radix polygonati officinalis improves mental activities; rhizoma Gastrodiae can extinguish wind and stop spasm; folium Eucommiae is effective in nourishing liver and kidney, and strengthening tendons and bones; cornus officinalis astringes and astringes; american ginseng tonifies qi and nourishes yin; the astragalus root has the functions of tonifying spleen and strengthening middle warmer; ganoderma lucidum can tonify qi and tranquilize mind. The prescription is an integral prescription, and after the prescription is combined, the prescription is beneficial to developing intelligence, refreshing brain, improving and improving memory, tonifying essence and blood and improving mental activities. Therefore, the safety is realized, and the uncomfortable feeling is avoided. In the preparation process of the composition, the extract is purified by using a macroporous adsorption resin chromatographic column, so that impurities with different properties can be removed, the purity and content of active ingredients in the extract are improved, and the efficacy of the medicine is improved.

Description

Herbal atomized composition for improving memory and preparation method thereof
Technical Field
The invention belongs to the technical field of Chinese herbal medicine atomized products, and particularly relates to a herbal atomized composition for improving memory and a preparation method thereof.
Background
Memory itself is a complex function of the nervous system, and dysfunction of any tissue in this system affects memory function and causes memory decline. The memory center of human body is in hippocampus, if the function of inner nucleus and outer nucleus is not perfect, the memory input and output information can not be completed effectively, and the control ability of intelligence and memory will be reduced. The hypofunction or the incomplete development of the neural connection between hippocampus and other brain tissues can cause serious memory impairment.
The hypomnesis can be caused by physiological reasons such as lack of exercise, lack of fresh air for breathing, excessive smoking and drinking and the like for a long time. Long-term psychological causes such as anxiety, depression, and excessive psychological stress can lead to hypomnesis. Neurasthenia, depression, cerebral arteriosclerosis, chronic sinusitis and other diseases can cause memory impairment. The memory function can be influenced by insufficient sleep for a long time, and neurasthenia patients often have sleep disorder, so that the neurasthenia patients have poor concentration and sleep disorder and have amnesia. Long-term smoking causes damage to the brain of a human, which can lead to memory loss as smokers age. It is proved by research that smoking is one of the risk factors of senile dementia, and one of the important causes of dementia is cerebral blood flow obstruction, and smoking can cause angiostenosis and cerebral blood supply insufficiency. Hypomnesis can occur after long-term drinking, which is a signal of chronic alcoholism.
The medicines and health-care products for improving the memory appear on the market, wherein western medicines usually damage organs due to adverse reactions or form medicine dependence and are not suitable for long-term taking, and pure natural foods or Chinese herbal medicines with the function of improving the memory have relatively few adverse reactions to human bodies and are suitable for long-term taking.
Disclosure of Invention
In order to solve the above problems of the prior art, the present invention aims to provide an herbal atomized composition for improving memory and a preparation method thereof.
The technical scheme adopted by the invention is as follows: a herbaceous atomization composition for improving memory is mainly prepared from the following raw materials in parts by mass:
30-60 parts of matcha, 3-9 parts of fructus alpiniae oxyphyllae, 9-15 parts of black sesame, 6-12 parts of radix polygonati officinalis, 6-12 parts of rhodiola rosea, 3-10 parts of rhizoma gastrodiae, 10-15 parts of folium cortex eucommiae, 5-10 parts of dogwood, 3-6 parts of American ginseng, 10-20 parts of astragalus membranaceus and 6-12 parts of lucid ganoderma.
Matcha is rich in nutrients and trace elements essential to human body, and contains tea polyphenol, caffeine, free amino acids, chlorophyll, protein, aromatic matter, cellulose, vitamin C, A, B1, B2, B3, B5, B6, E, K, H, etc. and trace elements over 30 kinds of K, Ca, Mg, Fe, Na, Zn, Se, F, etc.
Fructus Alpinae Oxyphyllae, named as Chinese medicine. Is fruit of Alpinia oxyphylla Miq. of genus Alpinia of family Zingiberaceae. Has effects of warming spleen, relieving diarrhea, arresting salivation, warming kidney, reducing urination, and stopping nocturnal emission. It can be used for treating deficiency cold of spleen and stomach, emesis, diarrhea, abdominal psychroalgia, excessive saliva, enuresis due to kidney deficiency, frequent micturition, spermatorrhea, and whitish and turbid urine. Pungent taste and warm nature; it enters spleen and kidney meridians.
Black sesame, name of traditional Chinese medicine. Is black seed of Sesamum indicum L. of Sesamum of Pedaliaceae. Has the effects of tonifying essence and blood, moistening dryness and lubricating intestines. It can be used for treating premature gray hair, dizziness, dim eyesight, puerperal lactation deficiency, rheumatism, blood deficiency, constipation, etc. Sweet in taste and neutral in nature; it enters liver, kidney and large intestine meridians.
Yuzhu, the name of Chinese medicine. Is rhizome of Druce (Polygonatum odoratum (Mill.) Druce) belonging to family Liliaceae, genus Polygonatum. Has effects in nourishing yin, moistening dryness, promoting salivation, and quenching thirst. It can be used for treating cough due to dryness-heat, thirst due to body fluid consumption, exogenous pathogenic factors due to yin deficiency, headache, and fever. Sweet in taste and neutral in nature; it enters lung and stomach meridians.
Rhodiola root, name of Chinese medicine. Is rhizome of rhodiola rosea Rholioa rosea limn. or rhodiola crenulata R.euryphylla (Frod.) S.H.Fu. of Crassulaceae. Has the effects of invigorating spleen, invigorating qi, clearing lung-heat, relieving cough, promoting blood circulation, and removing blood stasis. It is used for treating spleen qi deficiency syndrome, lung yin deficiency syndrome, and cough due to lung heat. Sweet taste and cold nature; it enters spleen and lung meridians.
Gastrodia elata, name of traditional Chinese medicine. Is dried tuber of Gastrodia elata Bl. of Gastrodia of Orchidaceae. Has effects of calming endogenous wind, relieving spasm, suppressing liver yang, dispelling pathogenic wind, and dredging collaterals. It can be used for treating stirring of liver-wind, convulsive epilepsy, convulsion, giddiness, headache, limbs anesthesia, hand and foot paralysis, and rheumatalgia. Sweet in taste and neutral in nature; it enters liver meridian.
Eucommia ulmoides leaves, which are plants of the family eucommia ulmoide, are called silk floss trees, silk floss barks and yu si barks, and have the same effective components and pharmacological action as eucommia ulmoides barks. The source is richer, the cost is lower, and the development and utilization prospect is better. The plant taxonomy belongs to the genus eucommia of family eucommia, only one of which belongs to the genus eucommia, and is extremely rare. And (4) efficacy classification: liver and kidney tonifying medicine; a muscle and bone strengthening drug; hypotensive drugs. Nature and taste: slightly pungent; and (4) temperature. The functions and indications are as follows: tonify liver and kidney, strengthen tendons and bones. Can be used for treating deficiency of liver and kidney, dizziness, soreness of waist and knees, and flaccidity of tendons and bones. Meridian tropism: entering the liver; the kidney channel. The main treatment is as follows: low back pain; soreness and weakness of the feet and knees; hypertension.
Cornus officinalis, the name of traditional Chinese medicine. Is dried mature pulp of Cornus officinalis Sieb.et Zucc. Has effects of invigorating liver and kidney, astringing and inducing astringency. Can be used for treating soreness of waist and knees, dizziness, tinnitus, sexual impotence, spermatorrhea, enuresis, frequent micturition, metrorrhagia, menorrhagia, profuse sweating, and asthenia. Sour and astringent taste, slightly warm nature; it enters liver and kidney meridians.
American ginseng, name of traditional Chinese medicine. Is root of Panax quinquefolium L. Has the effects of invigorating qi, nourishing yin, clearing away heat, and promoting fluid production. It is mainly indicated for syndrome of both qi and yin deficiency, syndrome of lung qi deficiency and lung yin deficiency, thirst due to deficiency of body fluid due to deficiency of heat disease, and diabetes. Sweet, slightly bitter and cool in nature; it enters lung, heart and kidney meridians. Chemical components: the product contains various ginsenosides, volatile components, resin, starch, saccharide, amino acids, and inorganic salts.
Astragalus root, name of traditional Chinese medicine. Is root of Astragalus membranaceus (Fisch.) Bge. of Astragalus of Leguminosae, Astragalus membranaceus (Astragalus membranaceus) Astragalus Memeranaceus (Var.) Bge. Hsiao or Astragalus membranaceus (Fisch.) Bge. Has effects in invigorating spleen, strengthening middle warmer, invigorating yang, lifting sink, invigorating defensive qi, consolidating superficial resistance, promoting urination, removing toxic materials, and promoting granulation. It is mainly indicated for spleen qi deficiency syndrome, lung qi deficiency syndrome, qi deficiency spontaneous sweating syndrome, qi and blood deficiency, ulcer and sore difficult to ulcerate and rot, or difficult to heal for a long time. Sweet in flavor and slightly warm in nature; it enters spleen and lung meridians.
Ganoderma lucidum and Chinese medicine name. Is dried fruiting body of Ganoderma lucidum (Leys. ex Fr.) Karst or Ganoderma sinense Zhao, Xu et Zhang of Ganoderma of Polyporaceae. Has effects of invigorating qi, tranquilizing mind, and relieving cough and asthma. It can be used for treating restlessness of heart-mind, insomnia, palpitation due to fright, cough, asthma, excessive phlegm, and asthenia. Sweet in taste and neutral in nature; it enters heart, lung, liver and kidney meridians. The chemical composition contains polysaccharide, nucleoside, furan, sterol, alkaloid, triterpenes, oil, amino acids, proteins, enzymes, organic germanium, trace elements, etc.
Preferably, the composition is mainly prepared from the following raw materials in parts by mass:
35-55 parts of matcha, 4-8 parts of fructus alpiniae oxyphyllae, 10-13 parts of black sesame, 7-10 parts of radix polygonati officinalis, 7-10 parts of rhodiola rosea, 4-9 parts of rhizoma gastrodiae, 11-14 parts of folium cortex eucommiae, 6-8 parts of dogwood, 4-5 parts of American ginseng, 12-18 parts of astragalus and 8-10 parts of lucid ganoderma.
Preferably, the composition is mainly prepared from the following raw materials in parts by mass:
45 parts of matcha, 6 parts of fructus alpiniae oxyphyllae, 11 parts of black sesame, 9 parts of radix polygonati officinalis, 9 parts of rhodiola rosea, 7 parts of rhizoma gastrodiae, 13 parts of folium cortex eucommiae, 7 parts of dogwood, 4.5 parts of American ginseng, 15 parts of astragalus and 9 parts of lucid ganoderma.
A method of preparing a herbal aerosolized composition for improving memory, the method comprising the steps of:
respectively selecting matcha, fructus alpiniae oxyphyllae, black sesame, polygonatum odoratum, rhodiola rosea, gastrodia elata, eucommia ulmoides leaves, dogwood, American ginseng, astragalus membranaceus and lucid ganoderma according to corresponding proportions, crushing to obtain green tea powder, fructus alpiniae oxyphyllae powder, black sesame powder, polygonatum odoratum powder, rhodiola rosea powder, gastrodia elata powder, eucommia ulmoides leaves powder, dogwood powder, American ginseng powder, astragalus membranaceus powder and lucid ganoderma powder for later use, and mixing to obtain raw material powder;
adding the raw material powder into an ethanol water solution after enzymolysis, and performing ultrasonic extraction to prepare an extracting solution;
adsorbing the extract by macroporous resin, eluting with ethanol water solution, collecting eluate, concentrating, and drying to obtain the final product.
Preferably, the enzyme for enzymolysis is a mixture of cellulase and/or pectinase;
the dosage of the enzyme for enzymolysis is 0.3-0.8% of the mass of the feed powder.
Preferably, the mass ratio of the cellulase to the pectinase is 1-2: 2-3.
Preferably, the mass fraction of the ethanol water solution is 30-75%.
Preferably, the power of the ultrasound is 80-100W, the ultrasound extraction time is 70-120min, and the ultrasound temperature is 45-55 ℃.
Preferably, the macroporous resin is AB-8 type or D-101 type resin.
Preferably, the volume of the macroporous resin is 8-10 times of the mass of the extracting solution;
the mass fraction of the ethanol water solution is 60-75%.
The invention has the beneficial effects that:
the invention provides a herbal atomized composition for improving memory, and an atomized product is prepared from pure plant Chinese herbal medicines.
The composition is mainly pungent in flavor and warm in nature; the spleen and kidney meridians are the therapeutic principles. Fructus Alpinae Oxyphyllae has effects of warming spleen, relieving diarrhea, arresting salivation, warming kidney, reducing urination, stopping nocturnal emission, resisting aging, and improving memory; the black sesame has the effects of tonifying essence and blood, moistening dryness and lubricating intestines; rhizoma Polygonati Odorati has effects of nourishing yin, moistening dryness, promoting fluid production, and quenching thirst; the rhodiola rosea has the effects of strengthening spleen and tonifying qi, clearing lung and relieving cough, and activating blood and dissolving stasis, improves the working efficiency and the mental activities, can enhance the excitability of a brain stem network system, enhance the response reaction to light and electrical stimulation, and adjust the content of central nervous system media to be normal; rhizoma Gastrodiae has effects of calming endogenous wind, relieving spasm, suppressing liver yang, dispelling pathogenic wind, and dredging collaterals; eucommia bark leaf, eucommia bark, Chinese angelica root, eucommia bark, Chinese angelica root, Chinese yam, Chinese angelica root, Chinese angelica root, Chinese angelica root, eucommia bark, Chinese angelica root, eucommia bark, root, eucommia bark, and rhizome, eucommia bark, root, eucommia bark, root, eucommia bark, all through a leaf, root, Chinese medicinal herbs according to be mentioned all through a root, Chinese medicinal herbs with the recipe and Chinese medicinal herbs with efficacy of eucommia bark, through a root, through a certain preparation. Can be used for treating deficiency of liver and kidney, dizziness, soreness of waist and knees, and flaccidity of tendons and bones; fructus Corni has effects of invigorating liver and kidney, astringing and inducing astringency; american ginseng has the effects of tonifying qi, nourishing yin, clearing heat and promoting fluid production; astragalus root, radix astragali, has effects of invigorating spleen, invigorating yang, lifting sinking, benefiting wei-defense, consolidating superficial resistance, promoting urination, expelling toxin, and promoting granulation; ganoderma has effects of invigorating qi, tranquilizing mind, and relieving cough and asthma. The prescription is an integral prescription, and after the prescription is combined, the prescription is beneficial to developing intelligence, refreshing brain, improving and improving memory, tonifying essence and blood and improving mental activities.
In the preparation process of the composition, the extract is purified by using a macroporous adsorption resin chromatographic column, so that impurities with different properties can be removed, the purity and content of active ingredients in the extract are improved, and the efficacy of the medicine is improved.
Detailed Description
The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.
Example 1:
a process for preparing an herbal aerosolized composition for improving memory, the process comprising the steps of:
respectively selecting 300 g of sharpleaf galangal fruit, 900 g of black sesame, 600 g of fragrant solomonseal rhizome, 600 g of rhodiola rosea, 300 g of tall gastrodia tuber, 1000 g of eucommia leaf, 500 g of common macrocarpium fruit, 300 g of American ginseng, 1000 g of astragalus root and 600 g of lucid ganoderma according to corresponding proportion, crushing to obtain spare materials of matcha powder, sharpleaf galangal fruit powder, black sesame powder, fragrant solomonseal rhizome powder, rhodiola rosea powder, tall gastrodia tuber powder, eucommia leaf powder, common macrocarpium fruit powder, American ginseng powder, astragalus root powder and lucid ganoderma powder, and mixing to obtain raw material powder;
decomposing raw material powder with cellulase, adding 30% ethanol water solution, and performing ultrasonic extraction at 45 deg.C for 70min (power 80w) to obtain extractive solution;
adsorbing the extract with AB-8 type macroporous resin, eluting with 75% ethanol water solution, collecting eluate, concentrating, and drying to obtain the final product.
Example 2:
a method of preparing a herbal aerosolized composition for improving memory, the method comprising the steps of:
selecting 900 g of sharpleaf galangal fruit, 1500 g of black sesame, 1200 g of fragrant solomonseal rhizome, 1200 g of rhodiola rosea, 1000 g of tall gastrodia tuber, 1500 g of eucommia leaf, 1000 g of dogwood, 600 g of American ginseng, 2000 g of astragalus and 1200 g of lucid ganoderma according to corresponding proportion, crushing to obtain spare materials of matcha powder, sharpleaf galangal fruit powder, black sesame powder, fragrant solomonseal rhizome powder, rhodiola rosea powder, tall gastrodia tuber powder, eucommia leaf powder, dogwood powder, American ginseng powder, astragalus powder and lucid ganoderma powder, and mixing to obtain raw material powder;
decomposing raw material powder with pectinase, adding 75% ethanol water solution, and performing ultrasonic extraction at 55 deg.C for 120min (power 80w) to obtain extractive solution;
adsorbing the extract with AB-8 type macroporous resin, eluting with 60% ethanol water solution, collecting eluate, concentrating, and drying to obtain the final product.
Example 3:
a method of preparing a herbal aerosolized composition for improving memory, the method comprising the steps of:
selecting 400 g of sharpleaf galangal fruit, 1000 g of black sesame, 700 g of fragrant solomonseal rhizome, 700 g of rhodiola rosea, 400 g of tall gastrodia tuber, 1100 g of eucommia leaf, 600 g of common macrocarpium fruit, 400 g of American ginseng, 1200 g of astragalus and 800 g of lucid ganoderma according to corresponding proportion, crushing to obtain green tea powder, sharpleaf galangal fruit powder, black sesame powder, fragrant solomonseal rhizome powder, rhodiola rosea powder, tall gastrodia tuber powder, eucommia leaf powder, common macrocarpium fruit powder, American ginseng powder, astragalus powder and lucid ganoderma powder for later use, and mixing to obtain raw material powder;
decomposing raw material powder with cellulase and pectinase (mass ratio of 1:2), adding 30% ethanol water solution, and performing ultrasonic extraction at 45 deg.C for 70min (power 100w) to obtain extractive solution;
adsorbing the extractive solution with D-101 type macroporous resin, eluting with 75% ethanol water solution, collecting eluate, concentrating, and drying to obtain the final product.
Example 4:
a method of preparing a herbal aerosolized composition for improving memory, the method comprising the steps of:
respectively selecting 800 g of sharpleaf galangal fruit, 1300 g of black sesame, 1000 g of fragrant solomonseal rhizome, 1000 g of rhodiola rosea, 900 g of tall gastrodia tuber, 1400 g of folium cortex eucommiae, 800 g of common macrocarpium fruit, 500 g of American ginseng, 1800 g of astragalus and 1000 g of lucid ganoderma according to corresponding proportion, crushing to obtain spare materials of matcha powder, sharpleaf galangal fruit powder, black sesame powder, fragrant solomonseal rhizome powder, rhodiola rosea powder, tall gastrodia tuber powder, eucommia leaf powder, common macrocarpium fruit powder, American ginseng powder, astragalus powder and lucid ganoderma powder, and mixing to obtain raw material powder;
decomposing raw material powder with cellulase and pectinase (mass ratio of 1:3), adding 75% ethanol water solution, and performing ultrasonic extraction at 45 deg.C for 120min (power of 80w) to obtain extractive solution;
adsorbing the extract with D-101 type macroporous resin, eluting with 60% ethanol water solution, collecting eluate, concentrating, and drying to obtain the final product.
Example 5:
a method of preparing a herbal aerosolized composition for improving memory, the method comprising the steps of:
respectively selecting 600 g of sharpleaf galangal fruit, 1100 g of black sesame, 900 g of polygonatum odoratum, 900 g of rhodiola rosea, 700 g of gastrodia elata, 1300 g of folium cortex eucommiae, 700 g of dogwood, 450 g of American ginseng, 1500 g of astragalus and 900 g of ganoderma lucidum according to corresponding proportion, crushing to obtain spare materials of matcha powder, sharpleaf galangal fruit powder, black sesame powder, polygonatum odoratum powder, rhodiola rosea powder, gastrodia elata powder, eucommia ulmoides leaf powder, dogwood powder, American ginseng powder, astragalus powder and ganoderma lucidum powder, and mixing to obtain raw material powder;
decomposing raw material powder with cellulase and pectinase (mass ratio of 2:3), adding 75% ethanol water solution, and performing ultrasonic extraction at 45 deg.C for 120min (power 100w) to obtain extractive solution;
adsorbing the extract with D-101 type macroporous resin, eluting with 750% ethanol water solution, collecting eluate, concentrating, and drying to obtain the final product.
The using method comprises the following steps: can be applied by adding into a daily atomizer.
The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.

Claims (10)

1. The herbal atomization composition for improving the memory is characterized by being prepared from the following raw materials in parts by mass:
30-60 parts of matcha, 3-9 parts of fructus alpiniae oxyphyllae, 9-15 parts of black sesame, 6-12 parts of radix polygonati officinalis, 6-12 parts of rhodiola rosea, 3-10 parts of rhizoma gastrodiae, 10-15 parts of folium cortex eucommiae, 5-10 parts of dogwood, 3-6 parts of American ginseng, 10-20 parts of astragalus membranaceus and 6-12 parts of lucid ganoderma.
2. The herbal atomized memory improving composition as claimed in claim 1, wherein the composition is prepared from the following raw materials in parts by mass:
35-55 parts of matcha, 4-8 parts of fructus alpiniae oxyphyllae, 10-13 parts of black sesame, 7-10 parts of polygonatum odoratum, 7-10 parts of rhodiola rosea, 4-9 parts of gastrodia elata, 11-14 parts of eucommia ulmoides leaves, 6-8 parts of dogwood, 4-5 parts of American ginseng, 12-18 parts of astragalus membranaceus and 8-10 parts of lucid ganoderma.
3. The herbal atomized memory improving composition as claimed in claim 2, wherein the composition is prepared from the following raw materials in parts by mass:
45 parts of matcha, 6 parts of fructus alpiniae oxyphyllae, 11 parts of black sesame, 9 parts of radix polygonati officinalis, 9 parts of rhodiola rosea, 7 parts of rhizoma gastrodiae, 13 parts of folium cortex eucommiae, 7 parts of dogwood, 4.5 parts of American ginseng, 15 parts of astragalus and 9 parts of lucid ganoderma.
4. A process for the preparation of a memory improving herbal aerosolized composition of any one of claims 1-3, said process comprising the steps of:
respectively selecting matcha, fructus alpiniae oxyphyllae, black sesame, radix polygonati officinalis, rhodiola rosea, rhizoma gastrodiae, folium cortex eucommiae, dogwood, American ginseng, radix astragali and lucid ganoderma according to corresponding proportions, crushing to obtain green tea powder, fructus alpiniae oxyphyllae powder, black sesame powder, polygonatum odoratum powder, rhodiola rosea powder, rhizoma gastrodiae powder, folium cortex eucommiae powder, dogwood powder, American ginseng powder, radix astragali powder and lucid ganoderma powder for later use, and mixing to obtain raw material powder;
adding the raw material powder into an ethanol water solution after enzymolysis, and performing ultrasonic extraction to prepare an extracting solution;
adsorbing the extract by macroporous resin, eluting with ethanol water solution, collecting eluate, concentrating, and drying to obtain the final product.
5. The method for preparing a memory improving herbal aerosolized composition of claim 4, wherein the enzyme for enzymatic hydrolysis is a mixture of cellulase and/or pectinase;
the dosage of the enzyme for enzymolysis is 0.3-0.8% of the mass of the feed powder.
6. The method for preparing a herbal atomized memory improving composition according to claim 5, wherein the mass ratio of the cellulase to the pectinase is 1-2: 2-3.
7. The preparation method of herbal atomized memory improving composition as claimed in claim 4, wherein the ethanol water solution is 30-75% by weight.
8. The method for preparing an herbal atomized composition for improving memory as claimed in claim 4, wherein the power of the ultrasound is 80-100W, the ultrasound extraction time is 70-120min, and the ultrasound temperature is 45-55 ℃.
9. The method of claim 4, wherein said macroporous resin is AB-8 type or D-101 type.
10. The method of claim 9, wherein the volume of the macroporous resin is 8-10 times the mass of the extractive solution;
the mass fraction of the ethanol water solution is 60-75%.
CN202210028830.XA 2022-01-11 2022-01-11 Herbal atomized composition for improving memory and preparation method thereof Pending CN114522213A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210028830.XA CN114522213A (en) 2022-01-11 2022-01-11 Herbal atomized composition for improving memory and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210028830.XA CN114522213A (en) 2022-01-11 2022-01-11 Herbal atomized composition for improving memory and preparation method thereof

Publications (1)

Publication Number Publication Date
CN114522213A true CN114522213A (en) 2022-05-24

Family

ID=81621835

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210028830.XA Pending CN114522213A (en) 2022-01-11 2022-01-11 Herbal atomized composition for improving memory and preparation method thereof

Country Status (1)

Country Link
CN (1) CN114522213A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116327880A (en) * 2023-03-08 2023-06-27 深圳雾芯科技有限公司 Nebulizable anti-fatigue pharmaceutical composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116327880A (en) * 2023-03-08 2023-06-27 深圳雾芯科技有限公司 Nebulizable anti-fatigue pharmaceutical composition

Similar Documents

Publication Publication Date Title
CN102212449B (en) Fagopyrum tataricm gaertn bud health-care wine
CN114522213A (en) Herbal atomized composition for improving memory and preparation method thereof
CN108887544A (en) A kind of natural health nourishing beverage
CN108850319A (en) A kind of preparation method with health functions instant tea powder
CN113274461A (en) Medicinal and edible health product and preparation method thereof
CN106109521A (en) A kind of Radix Notoginseng oral liquid
CN111587942A (en) Instant tea powder of sixteen kinds of natural Chinese herbal medicine and its prepn and use
CN111388639B (en) Phenylethanoid glycoside and isoflavone extract for relieving menopausal syndrome and application thereof
CN103920011A (en) Pharmaceutical composition for postpartum liver depression qi stagnation type hypogalactia and preparing method thereof
CN109876127B (en) Blood-nourishing angelica sinensis capsule and preparation method thereof
CN113018330A (en) Chinese patent medicine granules for treating cold and preparation method thereof
CN112402569A (en) Anti-fatigue health product and preparation method thereof
CN112220901A (en) Traditional Chinese medicine drop and preparation method thereof
CN112618425A (en) Preparation method of multi-effect repairing, moistening and hair nourishing essence
CN117503833B (en) A Chinese medicinal composition with yang supporting and kidney invigorating effects, and its preparation method
CN114470128A (en) Herbal atomized composition for promoting intelligence and refreshing brain and preparation method thereof
CN116459314B (en) Aging-delaying spray
CN1100949A (en) Cherokee rose health-care series products and preparing method thereof
CN1593547A (en) Method for preparing compound medicinal capsule and powder for nourishing yin
CN114432401A (en) Dried orange peel cough-relieving herbal atomized composition and preparation method and application thereof
CN106047617A (en) Health-care rice wine prepared from American ginseng
CN114404517A (en) Composition for gout and reducing uric acid and application and preparation method thereof
CN116983367A (en) Traditional Chinese medicine preparation for protecting liver, tonifying kidney and reducing four highs and preparation method thereof
CN113368196A (en) Traditional Chinese medicine mixture for treating wind-heat type common cold and preparation method thereof
CN116850240A (en) A preparation for strengthening body constitution, protecting liver, invigorating kidney, dredging meridian passage, and its preparation method

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20220524

WD01 Invention patent application deemed withdrawn after publication